CXCR6 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 9.73 docs)

VERSION

2018-07-10

MAIN TEMPLATE

κ receptor (sequence similarity: 49%) PDB: 6B73

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 75.1 17.5 7.4
Side-chains 23.2 55.2 21.5

Number of backbone templates: 8
Number of rotamer templates: 35

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5LWE
6B73
4DJH
4ZUD
3ODU
5T1A
5X33
4N6H
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 21 CCR9 5LWE CCR9 5LWE
N-term 22 CCR9 5LWE CCR9 5LWE
N-term 23 CCR9 5LWE CCR9 5LWE
N-term 24 CCR9 5LWE CCR9 5LWE
N-term 25 CCR9 5LWE CCR9 5LWE
TM1 26 1.27x27 CCR9 5LWE - -
TM1 27 1.28x28 CCR9 5LWE US28 4XT1
TM1 28 1.29x29 CCR9 5LWE CCR9 5LWE
TM1 29 1.30x30 κ receptor 6B73 PAF receptor 5ZKP
TM1 30 1.31x31 κ receptor 6B73 US28 4XT1
TM1 31 1.32x32 κ receptor 6B73 US28 4XT1
TM1 32 1.33x33 κ receptor 6B73 κ receptor 6B73
TM1 33 1.34x34 κ receptor 6B73 M2 receptor 4MQT
TM1 34 1.35x35 κ receptor 6B73 Rhodopsin 5DYS
TM1 35 1.36x36 κ receptor 6B73 AT2 receptor 5UNG
TM1 36 1.37x37 κ receptor 6B73 - -
TM1 37 1.38x38 κ receptor 6B73 - -
TM1 38 1.39x39 κ receptor 6B73 κ receptor 6B73
TM1 39 1.40x40 κ receptor 6B73 NTS1 receptor 5T04
TM1 40 1.41x41 κ receptor 6B73 κ receptor 6B73
TM1 41 1.42x42 κ receptor 6B73 κ receptor 6B73
TM1 42 1.43x43 κ receptor 6B73 κ receptor 6B73
TM1 43 1.44x44 κ receptor 6B73 κ receptor 6B73
TM1 44 1.45x45 κ receptor 6B73 - -
TM1 45 1.46x46 κ receptor 6B73 κ receptor 6B73
TM1 46 1.47x47 κ receptor 6B73 κ receptor 6B73
TM1 47 1.48x48 κ receptor 6B73 κ receptor 6B73
TM1 48 1.49x49 κ receptor 6B73 κ receptor 6B73
TM1 49 1.50x50 κ receptor 6B73 κ receptor 6B73
TM1 50 1.51x51 κ receptor 6B73 κ receptor 6B73
TM1 51 1.52x52 κ receptor 6B73 κ receptor 6B73
TM1 52 1.53x53 κ receptor 6B73 κ receptor 6B73
TM1 53 1.54x54 κ receptor 6B73 NTS1 receptor 5T04
TM1 54 1.55x55 κ receptor 6B73 M2 receptor 4MQT
TM1 55 1.56x56 κ receptor 6B73 LPA6 receptor 5XSZ
TM1 56 1.57x57 κ receptor 6B73 - -
TM1 57 1.58x58 κ receptor 6B73 κ receptor 6B73
TM1 58 1.59x59 κ receptor 6B73 AT1 receptor 4ZUD
TM1 59 1.60x60 κ receptor 6B73 κ receptor 6B73
ICL1 60 12.48x48 - - - -
ICL1 61 12.49x49 AT1 receptor 4ZUD 5-HT2C receptor 6BQG
ICL1 62 12.50x50 AT1 receptor 4ZUD AT1 receptor 4ZUD
ICL1 63 12.51x51 - - - -
TM2 64 2.37x37 κ receptor 6B73 CXCR4 3ODU
TM2 65 2.38x38 κ receptor 6B73 CCR2 5T1A
TM2 66 2.39x39 κ receptor 6B73 κ receptor 6B73
TM2 67 2.40x40 κ receptor 6B73 US28 4XT1
TM2 68 2.41x41 κ receptor 6B73 US28 4XT1
TM2 69 2.42x42 κ receptor 6B73 5-HT2B receptor 5TUD
TM2 70 2.43x43 κ receptor 6B73 5-HT2B receptor 5TUD
TM2 71 2.44x44 κ receptor 6B73 PAF receptor 5ZKP
TM2 72 2.45x45 κ receptor 6B73 κ receptor 6B73
TM2 73 2.46x46 κ receptor 6B73 κ receptor 6B73
TM2 74 2.47x47 κ receptor 6B73 - -
TM2 75 2.48x48 κ receptor 6B73 κ receptor 6B73
TM2 76 2.49x49 κ receptor 6B73 κ receptor 6B73
TM2 77 2.50x50 κ receptor 6B73 κ receptor 6B73
TM2 78 2.51x51 κ receptor 6B73 US28 4XT1
TM2 79 2.52x52 κ receptor 6B73 β2-adrenoceptor 3SN6
TM2 80 2.53x53 κ receptor 6B73 US28 4XT1
TM2 81 2.54x54 κ receptor 6B73 US28 4XT1
TM2 82 2.55x55 κ receptor 6B73 US28 4XT1
TM2 83 2.56x56 κ receptor 6B73 κ receptor 6B73
TM2 84 2.57x57 κ receptor 6B73 μ receptor 5C1M
TM2 85 2.58x58 κ receptor 6B73 κ receptor 6B73
TM2 86 2.59x59 κ receptor 6B73 κ receptor 6B73
TM2 87 2.60x60 κ receptor 6B73 US28 4XT1
TM2 88 2.61x61 κ receptor 6B73 AT2 receptor 5UNG
TM2 89 2.62x62 κ receptor 6B73 NTS1 receptor 5T04
TM2 90 2.63x63 κ receptor 6B73 5-HT2C receptor 6BQG
TM2 91 2.64x64 κ receptor 6B73 - -
TM2 92 2.65x65 κ receptor 6B73 NTS1 receptor 5T04
TM2 93 2.66x66 κ receptor 6B73 Rhodopsin 5DYS
ECL1 94 23.49x49 - - - -
ECL1 95 23.50x50 CXCR4 3ODU CXCR4 3ODU
ECL1 96 23.51x51 CXCR4 3ODU Rhodopsin 5DYS
ECL1 97 23.52x52 - - - -
TM3 98 3.21x21 κ receptor 6B73 κ receptor 6B73
TM3 99 3.22x22 κ receptor 6B73 OX2 receptor 5WS3
TM3 100 3.23x23 κ receptor 6B73 κ receptor 6B73
TM3 101 3.24x24 κ receptor 6B73 AT2 receptor 5UNG
TM3 102 3.25x25 κ receptor 6B73 κ receptor 6B73
TM3 103 3.26x26 κ receptor 6B73 κ receptor 6B73
TM3 104 3.27x27 κ receptor 6B73 - -
TM3 105 3.28x28 κ receptor 6B73 US28 4XT1
TM3 106 3.29x29 κ receptor 6B73 κ receptor 6B73
TM3 107 3.30x30 κ receptor 6B73 CB1 receptor 5XRA
TM3 108 3.31x31 κ receptor 6B73 κ receptor 6B73
TM3 109 3.32x32 κ receptor 6B73 CCR9 5LWE
TM3 110 3.33x33 κ receptor 6B73 AT2 receptor 5UNG
TM3 111 3.34x34 κ receptor 6B73 PAF receptor 5ZKP
TM3 112 3.35x35 κ receptor 6B73 κ receptor 6B73
TM3 113 3.36x36 κ receptor 6B73 CB1 receptor 5XRA
TM3 114 3.37x37 κ receptor 6B73 LPA6 receptor 5XSZ
TM3 115 3.38x38 κ receptor 6B73 κ receptor 6B73
TM3 116 3.39x39 κ receptor 6B73 κ receptor 6B73
TM3 117 3.40x40 κ receptor 6B73 - -
TM3 118 3.41x41 κ receptor 6B73 LPA6 receptor 5XSZ
TM3 119 3.42x42 κ receptor 6B73 CXCR4 3ODU
TM3 120 3.43x43 κ receptor 6B73 κ receptor 6B73
TM3 121 3.44x44 κ receptor 6B73 κ receptor 6B73
TM3 122 3.45x45 κ receptor 6B73 LPA6 receptor 5XSZ
TM3 123 3.46x46 κ receptor 6B73 US28 4XT1
TM3 124 3.47x47 κ receptor 6B73 PAF receptor 5ZKP
TM3 125 3.48x48 κ receptor 6B73 κ receptor 6B73
TM3 126 3.49x49 κ receptor 6B73 κ receptor 6B73
TM3 127 3.50x50 κ receptor 6B73 κ receptor 6B73
TM3 128 3.51x51 κ receptor 6B73 LPA6 receptor 5XSZ
TM3 129 3.52x52 κ receptor 6B73 κ receptor 6B73
TM3 130 3.53x53 κ receptor 6B73 Rhodopsin 5DYS
TM3 131 3.54x54 κ receptor 6B73 κ receptor 6B73
TM3 132 3.55x55 κ receptor 6B73 US28 4XT1
TM3 133 3.56x56 κ receptor 6B73 Rhodopsin 5DYS
ICL2 134 34.50x50 κ receptor 6B73 5-HT1B receptor 6G79
ICL2 135 34.51x51 κ receptor 6B73 - -
ICL2 136 34.52x52 κ receptor 6B73 κ receptor 6B73
ICL2 137 34.53x53 κ receptor 6B73 κ receptor 6B73
ICL2 138 34.54x54 κ receptor 6B73 - -
ICL2 139 34.55x55 κ receptor 6B73 C5a1 receptor 6C1R
ICL2 140 34.56x56 κ receptor 6B73 - -
ICL2 141 34.57x57 κ receptor 6B73 - -
ICL2 142 34.58x58 - - - -
ICL2 143 - - - -
TM4 144 4.38x38 κ receptor 6B73 FFA1 receptor 5TZY
TM4 145 4.39x39 κ receptor 6B73 AT1 receptor 4ZUD
TM4 146 4.40x40 κ receptor 6B73 5-HT2C receptor 6BQG
TM4 147 4.41x41 κ receptor 6B73 ETB receptor 5X93
TM4 148 4.42x42 κ receptor 6B73 CCR2 5T1A
TM4 149 4.43x43 κ receptor 6B73 κ receptor 6B73
TM4 150 4.44x44 κ receptor 6B73 β2-adrenoceptor 3SN6
TM4 151 4.45x45 κ receptor 6B73 CCR2 5T1A
TM4 152 4.46x46 κ receptor 6B73 US28 4XT1
TM4 153 4.47x47 κ receptor 6B73 β2-adrenoceptor 3SN6
TM4 154 4.48x48 κ receptor 6B73 AT2 receptor 5UNG
TM4 155 4.49x49 κ receptor 6B73 κ receptor 6B73
TM4 156 4.50x50 κ receptor 6B73 κ receptor 6B73
TM4 157 4.51x51 κ receptor 6B73 LPA6 receptor 5XSZ
TM4 158 4.52x52 κ receptor 6B73 5-HT2B receptor 5TUD
TM4 159 4.53x53 κ receptor 6B73 κ receptor 6B73
TM4 160 4.54x54 κ receptor 6B73 LPA6 receptor 5XSZ
TM4 161 4.55x55 κ receptor 6B73 AT2 receptor 5UNG
TM4 162 4.56x56 κ receptor 6B73 κ receptor 6B73
TM4 163 4.57x57 CCR9 5LWE LPA6 receptor 5XSZ
TM4 164 4.58x59 CCR9 5LWE AT2 receptor 5UNG
TM4 165 4.59x60 κ receptor 6B73 US28 4XT1
TM4 166 4.60x61 κ receptor 6B73 OX2 receptor 5WS3
TM4 167 4.61x62 κ receptor 6B73 PAF receptor 5ZKP
TM4 168 4.62x63 κ receptor 6B73 5-HT2B receptor 5TUD
TM4 169 4.63x64 κ receptor 6B73 - -
TM4 170 4.64x65 CXCR4 3ODU 5-HT2B receptor 4IB4
ECL2 171 - - - -
ECL2 172 - - - -
ECL2 173 CCR2 5T1A - -
ECL2 174 CCR2 5T1A - -
ECL2 175 CCR2 5T1A - -
ECL2 176 CCR2 5T1A - -
ECL2 177 CCR2 5T1A - -
ECL2 178 CCR2 5T1A - -
ECL2 179 - - - -
ECL2 180 45.50x50 κ receptor 6B73 κ receptor 6B73
ECL2 181 45.51x51 κ receptor 6B73 Rhodopsin 5DYS
ECL2 182 45.52x52 κ receptor 6B73 - -
ECL2 183 - - - -
ECL2 184 BLT1 receptor 5X33 - -
ECL2 185 - - - -
TM5 186 5.33x34 κ receptor 6B73 NTS1 receptor 5T04
TM5 187 5.34x35 κ receptor 6B73 - -
TM5 188 5.35x36 κ receptor 6B73 AT2 receptor 5UNG
TM5 189 5.36x37 κ receptor 6B73 δ receptor 4N6H
TM5 190 5.37x38 κ receptor 6B73 NTS1 receptor 5T04
TM5 191 5.38x39 κ receptor 6B73 LPA6 receptor 5XSZ
TM5 192 5.39x40 κ receptor 6B73 CB1 receptor 5XRA
TM5 193 5.40x41 κ receptor 6B73 PAR1 3VW7
TM5 194 5.41x42 κ receptor 6B73 AT1 receptor 4ZUD
TM5 195 5.42x43 κ receptor 6B73 - -
TM5 196 5.43x44 κ receptor 6B73 US28 4XT1
TM5 197 5.44x45 κ receptor 6B73 LPA6 receptor 5XSZ
TM5 198 5.45x46 κ receptor 6B73 AT2 receptor 5UNG
TM5 199 5.46x461 κ receptor 6B73 LPA6 receptor 5XSZ
TM5 200 5.47x47 κ receptor 6B73 κ receptor 6B73
TM5 201 5.48x48 κ receptor 6B73 5-HT2B receptor 5TUD
TM5 202 5.49x49 κ receptor 6B73 PAF receptor 5ZKP
TM5 203 5.50x50 κ receptor 6B73 κ receptor 6B73
TM5 204 5.51x51 κ receptor 6B73 US28 4XT1
TM5 205 5.52x52 κ receptor 6B73 κ receptor 6B73
TM5 206 5.53x53 κ receptor 6B73 C5a1 receptor 5O9H
TM5 207 5.54x54 κ receptor 6B73 5-HT2B receptor 5TUD
TM5 208 5.55x55 κ receptor 6B73 κ receptor 6B73
TM5 209 5.56x56 κ receptor 6B73 κ receptor 6B73
TM5 210 5.57x57 κ receptor 6B73 κ receptor 6B73
TM5 211 5.58x58 κ receptor 6B73 κ receptor 6B73
TM5 212 5.59x59 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 213 5.60x60 κ receptor 6B73 NTS1 receptor 5T04
TM5 214 5.61x61 κ receptor 6B73 US28 4XT1
TM5 215 5.62x62 κ receptor 6B73 κ receptor 6B73
TM5 216 5.63x63 κ receptor 6B73 AT2 receptor 5UNG
TM5 217 5.64x64 κ receptor 6B73 LPA6 receptor 5XSZ
TM5 218 5.65x65 κ receptor 6B73 κ receptor 6B73
TM5 219 5.66x66 κ receptor 6B73 AT2 receptor 5UNG
TM5 220 5.67x67 κ receptor 6B73 CXCR4 3OE0
TM5 221 5.68x68 κ receptor 4DJH Rhodopsin 5DYS
ICL3 222 - - - -
ICL3 223 - - - -
ICL3 224 - - - -
ICL3 225 - - - -
TM6 226 6.30x30 κ receptor 6B73 US28 4XT1
TM6 227 6.31x31 κ receptor 6B73 β2-adrenoceptor 4LDE
TM6 228 6.32x32 κ receptor 6B73 μ receptor 5C1M
TM6 229 6.33x33 κ receptor 6B73 - -
TM6 230 6.34x34 κ receptor 6B73 LPA6 receptor 5XSZ
TM6 231 6.35x35 κ receptor 6B73 AT2 receptor 5UNG
TM6 232 6.36x36 κ receptor 6B73 AT1 receptor 4ZUD
TM6 233 6.37x37 κ receptor 6B73 LPA6 receptor 5XSZ
TM6 234 6.38x38 κ receptor 6B73 CCR2 5T1A
TM6 235 6.39x39 κ receptor 6B73 A1 receptor 6D9H
TM6 236 6.40x40 κ receptor 6B73 κ receptor 6B73
TM6 237 6.41x41 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 238 6.42x42 κ receptor 6B73 κ receptor 6B73
TM6 239 6.43x43 κ receptor 6B73 κ receptor 6B73
TM6 240 6.44x44 κ receptor 6B73 κ receptor 6B73
TM6 241 6.45x45 κ receptor 6B73 5-HT2B receptor 5TUD
TM6 242 6.46x46 κ receptor 6B73 5-HT2B receptor 5TUD
TM6 243 6.47x47 κ receptor 6B73 M2 receptor 4MQT
TM6 244 6.48x48 κ receptor 6B73 CCR9 5LWE
TM6 245 6.49x49 κ receptor 6B73 apelin receptor 5VBL
TM6 246 6.50x50 κ receptor 6B73 κ receptor 6B73
TM6 247 6.51x51 κ receptor 6B73 AT2 receptor 5UNG
TM6 248 6.52x52 κ receptor 6B73 LPA6 receptor 5XSZ
TM6 249 6.53x53 κ receptor 6B73 US28 4XT1
TM6 250 6.54x54 κ receptor 6B73 M2 receptor 4MQT
TM6 251 6.55x55 κ receptor 6B73 apelin receptor 5VBL
TM6 252 6.56x56 κ receptor 6B73 US28 4XT1
TM6 253 6.57x57 κ receptor 6B73 μ receptor 5C1M
TM6 254 6.58x58 κ receptor 6B73 - -
TM6 255 6.59x59 κ receptor 6B73 LPA6 receptor 5XSZ
TM6 256 6.60x60 κ receptor 6B73 Rhodopsin 5DYS
TM6 257 6.61x61 κ receptor 6B73 Rhodopsin 5DYS
ECL3 258 - - - -
ECL3 259 δ receptor 4N6H - -
ECL3 260 δ receptor 4N6H - -
ECL3 261 δ receptor 4N6H - -
ECL3 262 - - - -
TM7 263 7.28x27 κ receptor 6B73 - -
TM7 264 7.29x28 κ receptor 6B73 κ receptor 6B73
TM7 265 7.30x29 κ receptor 6B73 US28 4XT1
TM7 266 7.31x30 κ receptor 6B73 - -
TM7 267 7.32x31 κ receptor 6B73 NTS1 receptor 5T04
TM7 268 7.33x32 κ receptor 6B73 NTS1 receptor 5T04
TM7 269 7.34x33 κ receptor 6B73 P2Y1 receptor 4XNW
TM7 270 7.35x34 κ receptor 6B73 CXCR4 3ODU
TM7 271 7.36x35 κ receptor 6B73 NTS1 receptor 5T04
TM7 272 7.37x36 κ receptor 6B73 5-HT2C receptor 6BQG
TM7 273 7.38x37 κ receptor 6B73 US28 4XT1
TM7 274 7.39x38 κ receptor 6B73 US28 4XT1
TM7 275 7.40x39 κ receptor 6B73 κ receptor 6B73
TM7 276 7.41x40 κ receptor 6B73 LPA6 receptor 5XSZ
TM7 277 7.42x41 κ receptor 6B73 US28 4XT1
TM7 278 7.43x42 κ receptor 6B73 κ receptor 6B73
TM7 279 7.44x43 κ receptor 6B73 CB1 receptor 5XRA
TM7 280 7.45x45 κ receptor 6B73 - -
TM7 281 7.46x46 κ receptor 6B73 Rhodopsin 5DYS
TM7 282 7.47x47 κ receptor 6B73 μ receptor 5C1M
TM7 283 7.48x48 κ receptor 6B73 κ receptor 6B73
TM7 284 7.49x49 κ receptor 6B73 κ receptor 6B73
TM7 285 7.50x50 κ receptor 6B73 κ receptor 6B73
TM7 286 7.51x51 κ receptor 6B73 μ receptor 6DDF
TM7 287 7.52x52 CCR9 5LWE CCR9 5LWE
TM7 288 7.53x53 CCR9 5LWE CCR9 5LWE
TM7 289 7.54x54 CCR9 5LWE μ receptor 6DDF
TM7 290 7.55x55 CCR9 5LWE CCR9 5LWE
TM7 291 7.56x56 CCR9 5LWE CCR9 5LWE
H8 292 8.47x47 CCR9 5LWE β2-adrenoceptor 3SN6
H8 293 8.48x48 CCR9 5LWE - -
H8 294 8.49x49 CCR9 5LWE A1 receptor 6D9H
H8 295 8.50x50 CCR9 5LWE US28 4XT1
H8 296 8.51x51 CCR9 5LWE CCR9 5LWE
H8 297 8.52x52 CCR9 5LWE D3 receptor 3PBL
H8 298 8.53x53 CCR9 5LWE - -
H8 299 8.54x54 CCR9 5LWE 5-HT2B receptor 5TUD
H8 300 8.55x55 CCR9 5LWE - -
H8 301 8.56x56 CCR9 5LWE A2A receptor 5G53
H8 302 8.57x57 CCR9 5LWE US28 4XT1
H8 303 8.58x58 CCR9 5LWE - -
H8 304 8.59x59 CCR9 5LWE CCR9 5LWE
H8 305 8.60x60 CCR9 5LWE A1 receptor 5UEN
H8 306 8.61x61 CCR9 5LWE - -
H8 307 8.62x62 CCR9 5LWE CCR9 5LWE
H8 308 8.63x63 CCR9 5LWE - -
H8 309 8.64x64 CCR9 5LWE - -
H8 310 8.65x65 CCR9 5LWE - -
H8 311 8.66x66 CCR9 5LWE - -
H8 312 8.67x67 CCR9 5LWE - -
C-term 313 - - - -
C-term 314 - - - -
C-term 315 - - - -
C-term 316 - - - -
C-term 317 - - - -