FFA2 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive (Δ distance (Å): 1.03 docs)

VERSION

2018-07-10

MAIN TEMPLATE

CCR5 (sequence similarity: 39%) PDB: 5UIW

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 80.1 6.4 13.5
Side-chains 17.6 58.1 24.3

Number of backbone templates: 4
Number of rotamer templates: 41

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5UIW
5NDD
5TZY
5ZKP
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 1 CCR5 5UIW CCR5 5UIW
N-term 2 CCR5 5UIW CCR5 5UIW
TM1 3 1.28x28 CCR5 5UIW A2A receptor 5IU4
TM1 4 1.29x29 CCR5 5UIW - -
TM1 5 1.30x30 CCR5 5UIW Rhodopsin 1GZM
TM1 6 1.31x31 CCR5 5UIW - -
TM1 7 1.32x32 CCR5 5UIW CCR9 5LWE
TM1 8 1.33x33 CCR5 5UIW Rhodopsin 1GZM
TM1 9 1.34x34 CCR5 5UIW CCR5 5UIW
TM1 10 1.35x35 CCR5 5UIW κ receptor 4DJH
TM1 11 1.36x36 CCR5 5UIW D4 receptor 5WIV
TM1 12 1.37x37 CCR5 5UIW LPA6 receptor 5XSZ
TM1 13 1.38x38 CCR5 5UIW OX1 receptor 4ZJ8
TM1 14 1.39x39 CCR5 5UIW CCR5 5UIW
TM1 15 1.40x40 CCR5 5UIW OX2 receptor 5WS3
TM1 16 1.41x41 CCR5 5UIW CXCR4 3ODU
TM1 17 1.42x42 CCR5 5UIW H1 receptor 3RZE
TM1 18 1.43x43 CCR5 5UIW CCR5 5UIW
TM1 19 1.44x44 CCR5 5UIW H1 receptor 3RZE
TM1 20 1.45x45 CCR5 5UIW CXCR4 3ODU
TM1 21 1.46x46 CCR5 5UIW CCR5 5UIW
TM1 22 1.47x47 CCR5 5UIW κ receptor 4DJH
TM1 23 1.48x48 CCR5 5UIW Rhodopsin 1GZM
TM1 24 1.49x49 CCR5 5UIW LPA1 receptor 4Z35
TM1 25 1.50x50 CCR5 5UIW CCR5 5UIW
TM1 26 1.51x51 CCR5 5UIW H1 receptor 3RZE
TM1 27 1.52x52 CCR5 5UIW CCR5 5UIW
TM1 28 1.53x53 CCR5 5UIW PAR2 5NDD
TM1 29 1.54x54 CCR5 5UIW H1 receptor 3RZE
TM1 30 1.55x55 CCR5 5UIW FFA1 receptor 5TZR
TM1 31 1.56x56 CCR5 5UIW H1 receptor 3RZE
TM1 32 1.57x57 CCR5 5UIW M1 receptor 5CXV
TM1 33 1.58x58 CCR5 5UIW μ receptor 4DKL
TM1 34 1.59x59 CCR5 5UIW - -
TM1 35 1.60x60 CCR5 5UIW PAR2 5NDD
ICL1 36 - - - -
ICL1 37 - - - -
ICL1 38 - - - -
ICL1 39 - - - -
ICL1 40 - - - -
ICL1 41 - - - -
TM2 42 2.37x37 CCR5 5UIW PAR2 5NDD
TM2 43 2.38x38 CCR5 5UIW D4 receptor 5WIV
TM2 44 2.39x39 CCR5 5UIW NTS1 receptor 4BUO
TM2 45 2.40x40 CCR5 5UIW NTS1 receptor 4XES
TM2 46 2.41x41 CCR5 5UIW CCR5 5UIW
TM2 47 2.42x42 CCR5 5UIW D3 receptor 3PBL
TM2 48 2.43x43 CCR5 5UIW CCR5 5UIW
TM2 49 2.44x44 CCR5 5UIW CCR5 5UIW
TM2 50 2.45x45 CCR5 5UIW H1 receptor 3RZE
TM2 51 2.46x46 CCR5 5UIW CCR5 5UIW
TM2 52 2.47x47 CCR5 5UIW PAF receptor 5ZKP
TM2 53 2.48x48 CCR5 5UIW κ receptor 4DJH
TM2 54 2.49x49 CCR5 5UIW κ receptor 4DJH
TM2 55 2.50x50 CCR5 5UIW CCR5 5UIW
TM2 56 2.51x51 CCR5 5UIW CCR5 5UIW
TM2 57 2.52x52 CCR5 5UIW κ receptor 4DJH
TM2 58 2.53x53 CCR5 5UIW D4 receptor 5WIV
TM2 59 2.54x54 CCR5 5UIW CCR5 5UIW
TM2 60 2.55x55 CCR5 5UIW CCR5 5UIW
TM2 61 2.56x56 CCR5 5UIW - -
TM2 62 2.57x57 CCR5 5UIW CXCR4 3ODU
TM2 63 2.58x58 CCR5 5UIW CCR5 5UIW
TM2 64 2.59x59 CCR5 5UIW CCR5 5UIW
TM2 65 2.60x60 CCR5 5UIW PAR2 5NDD
TM2 66 2.61x61 CCR5 5UIW H1 receptor 3RZE
TM2 67 2.62x62 CCR5 5UIW CCR9 5LWE
TM2 68 2.63x63 CCR5 5UIW FFA1 receptor 5TZY
TM2 69 2.64x64 CCR5 5UIW CCR5 5UIW
TM2 70 2.65x65 CCR5 5UIW CCR5 5UIW
TM2 71 2.66x66 CCR5 5UIW - -
ECL1 72 - - - -
ECL1 73 PAR2 5NDD - -
ECL1 74 23.49x49 PAR2 5NDD AT1 receptor 4ZUD
ECL1 75 23.50x50 PAR2 5NDD PAR2 5NDD
ECL1 76 23.51x51 PAR2 5NDD CXCR4 3ODU
ECL1 77 23.52x52 - - - -
TM3 78 3.21x21 CCR5 5UIW 5-HT2C receptor 6BQH
TM3 79 3.22x22 CCR5 5UIW PAF receptor 5ZKP
TM3 80 3.23x23 CCR5 5UIW κ receptor 4DJH
TM3 81 3.24x24 CCR5 5UIW M2 receptor 3UON
TM3 82 3.25x25 CCR5 5UIW CCR5 5UIW
TM3 83 3.26x26 CCR5 5UIW - -
TM3 84 3.27x27 CCR5 5UIW CCR5 5UIW
TM3 85 3.28x28 CCR5 5UIW P2Y12 receptor 4NTJ
TM3 86 3.29x29 CCR5 5UIW AT1 receptor 4ZUD
TM3 87 3.30x30 CCR5 5UIW ETB receptor 5X93
TM3 88 3.31x31 CCR5 5UIW CB1 receptor 5TGZ
TM3 89 3.32x32 CCR5 5UIW PAR2 5NDD
TM3 90 3.33x33 CCR5 5UIW κ receptor 4DJH
TM3 91 3.34x34 CCR5 5UIW - -
TM3 92 3.35x35 CCR5 5UIW OX2 receptor 5WS3
TM3 93 3.36x36 CCR5 5UIW Y1 receptor 5ZBH
TM3 94 3.37x37 CCR5 5UIW CXCR4 3ODU
TM3 95 3.38x38 CCR5 5UIW PAR2 5NDD
TM3 96 3.39x39 CCR5 5UIW κ receptor 4DJH
TM3 97 3.40x40 CCR5 5UIW NOP receptor 5DHG
TM3 98 3.41x41 CCR5 5UIW CXCR4 3ODU
TM3 99 3.42x42 CCR5 5UIW AT1 receptor 4ZUD
TM3 100 3.43x43 CCR5 5UIW κ receptor 4DJH
TM3 101 3.44x44 CCR5 5UIW CXCR4 3ODU
TM3 102 3.45x45 CCR5 5UIW apelin receptor 5VBL
TM3 103 3.46x46 CCR5 5UIW CXCR4 3ODU
TM3 104 3.47x47 CCR5 5UIW κ receptor 4DJH
TM3 105 3.48x48 CCR5 5UIW CCR5 5UIW
TM3 106 3.49x49 CCR5 5UIW Rhodopsin 1GZM
TM3 107 3.50x50 CCR5 5UIW CCR5 5UIW
TM3 108 3.51x51 CCR5 5UIW CCR5 5UIW
TM3 109 3.52x52 CCR5 5UIW CCR5 5UIW
TM3 110 3.53x53 CCR5 5UIW FFA1 receptor 5TZY
TM3 111 3.54x54 CCR5 5UIW CCR5 5UIW
TM3 112 3.55x55 CCR5 5UIW CCR9 5LWE
TM3 113 3.56x56 CCR5 5UIW FFA1 receptor 5TZY
ICL2 114 34.50x50 - - - -
ICL2 115 34.51x51 FFA1 receptor 5TZY CCR5 4MBS
ICL2 116 34.52x52 FFA1 receptor 5TZY - -
ICL2 117 34.53x53 FFA1 receptor 5TZY FFA1 receptor 5TZY
ICL2 118 34.54x54 FFA1 receptor 5TZY A1 receptor 5UEN
ICL2 119 34.55x55 FFA1 receptor 5TZY - -
ICL2 120 34.56x56 FFA1 receptor 5TZY - -
ICL2 121 34.57x57 - - - -
TM4 122 4.38x38 CCR5 5UIW FFA1 receptor 5TZY
TM4 123 4.39x39 CCR5 5UIW κ receptor 4DJH
TM4 124 4.40x40 CCR5 5UIW κ receptor 4DJH
TM4 125 4.41x41 CCR5 5UIW CCR9 5LWE
TM4 126 4.42x42 CCR5 5UIW CCR5 5UIW
TM4 127 4.43x43 CCR5 5UIW CCR5 5UIW
TM4 128 4.44x44 CCR5 5UIW κ receptor 4DJH
TM4 129 4.45x45 CCR5 5UIW apelin receptor 5VBL
TM4 130 4.46x46 CCR5 5UIW - -
TM4 131 4.47x47 CCR5 5UIW H1 receptor 3RZE
TM4 132 4.48x48 CCR5 5UIW apelin receptor 5VBL
TM4 133 4.49x49 CCR5 5UIW H1 receptor 3RZE
TM4 134 4.50x50 CCR5 5UIW CCR5 5UIW
TM4 135 4.51x51 CCR5 5UIW CCR5 5UIW
TM4 136 4.52x52 CCR5 5UIW Rhodopsin 1GZM
TM4 137 4.53x53 CCR5 5UIW κ receptor 4DJH
TM4 138 4.54x54 CCR5 5UIW H1 receptor 3RZE
TM4 139 4.55x55 CCR5 5UIW 5-HT2C receptor 6BQH
TM4 140 4.56x56 CCR5 5UIW FFA1 receptor 5TZY
TM4 141 4.57x57 FFA1 receptor 5TZY CCR9 5LWE
TM4 142 4.58x58 FFA1 receptor 5TZY - -
TM4 143 4.59x59 FFA1 receptor 5TZY H1 receptor 3RZE
TM4 144 4.60x60 CCR5 5UIW μ receptor 4DKL
TM4 145 4.61x61 CCR5 5UIW κ receptor 4DJH
TM4 146 4.62x62 CCR5 5UIW CCR5 5UIW
ECL2 147 - - - -
ECL2 148 - - - -
ECL2 149 - - - -
ECL2 150 - - - -
ECL2 151 - - - -
ECL2 152 - - - -
ECL2 153 - - - -
ECL2 154 - - - -
ECL2 155 - - - -
ECL2 156 - - - -
ECL2 157 - - - -
ECL2 158 - - - -
ECL2 159 - - - -
ECL2 160 - - - -
ECL2 161 - - - -
ECL2 162 - - - -
ECL2 163 - - - -
ECL2 164 45.50x50 CCR5 5UIW CCR5 5UIW
ECL2 165 45.51x51 CCR5 5UIW apelin receptor 5VBL
ECL2 166 45.52x52 CCR5 5UIW OX2 receptor 5WS3
ECL2 167 CCR5 5UIW - -
ECL2 168 CCR5 5UIW CCR5 5UIW
ECL2 169 CCR5 5UIW - -
ECL2 170 CCR5 5UIW - -
ECL2 171 CCR5 5UIW - -
TM5 172 5.31x32 CCR5 5UIW NOP receptor 5DHG
TM5 173 5.32x33 CCR5 5UIW P2Y1 receptor 4XNW
TM5 174 5.33x34 CCR5 5UIW - -
TM5 175 5.34x35 CCR5 5UIW - -
TM5 176 5.35x36 CCR5 5UIW CXCR4 3ODU
TM5 177 5.36x37 CCR5 5UIW κ receptor 4DJH
TM5 178 5.37x38 CCR5 5UIW FFA1 receptor 5TZY
TM5 179 5.38x39 CCR5 5UIW C5a1 receptor 5O9H
TM5 180 5.39x40 CCR5 5UIW FFA1 receptor 5TZY
TM5 181 5.40x41 CCR5 5UIW CCR5 5UIW
TM5 182 5.41x42 CCR5 5UIW US28 4XT1
TM5 183 5.42x43 CCR5 5UIW ETB receptor 5X93
TM5 184 5.43x44 CCR5 5UIW - -
TM5 185 5.44x45 CCR5 5UIW δ receptor 4N6H
TM5 186 5.45x46 CCR5 5UIW CXCR4 3ODU
TM5 187 5.46x461 CCR5 5UIW FFA1 receptor 5TZY
TM5 188 5.47x47 CCR5 5UIW κ receptor 4DJH
TM5 189 5.48x48 CCR5 5UIW 5-HT2C receptor 6BQH
TM5 190 5.49x49 CCR5 5UIW κ receptor 4DJH
TM5 191 5.50x50 CCR5 5UIW CCR5 5UIW
TM5 192 5.51x51 CCR5 5UIW NTS1 receptor 4BUO
TM5 193 5.52x52 CCR5 5UIW ETB receptor 5X93
TM5 194 5.53x53 CCR5 5UIW CCR5 5UIW
TM5 195 5.54x54 CCR5 5UIW D3 receptor 3PBL
TM5 196 5.55x55 CCR5 5UIW κ receptor 4DJH
TM5 197 5.56x56 CCR5 5UIW ETB receptor 5X93
TM5 198 5.57x57 CCR5 5UIW CCR5 5UIW
TM5 199 5.58x58 CCR5 5UIW CCR5 5UIW
TM5 200 5.59x59 CCR5 5UIW D4 receptor 5WIV
TM5 201 5.60x60 CCR5 5UIW D3 receptor 3PBL
TM5 202 5.61x61 CCR5 5UIW - -
TM5 203 5.62x62 CCR5 5UIW Rhodopsin 1GZM
TM5 204 5.63x63 CCR5 5UIW CB1 receptor 5TGZ
TM5 205 5.64x64 CCR5 5UIW US28 4XT1
TM5 206 5.65x65 CCR5 5UIW ETB receptor 5X93
TM5 207 5.66x66 CCR5 5UIW CCR5 5UIW
TM5 208 5.67x67 CCR5 5UIW PAR1 3VW7
ICL3 209 - - - -
ICL3 210 - - - -
ICL3 211 - - - -
ICL3 212 - - - -
TM6 213 6.26x27 PAR2 5NDD CXCR4 3ODU
TM6 214 6.27x28 CCR5 5UIW PAF receptor 5ZKP
TM6 215 6.28x29 CCR5 5UIW CXCR4 3ODU
TM6 216 6.29x30 CCR5 5UIW CCR5 5UIW
TM6 217 6.30x31 CCR5 5UIW H1 receptor 3RZE
TM6 218 6.31x32 CCR5 5UIW CCR5 5UIW
TM6 219 6.32x33 CCR5 5UIW PAR2 5NDD
TM6 220 6.33x34 CCR5 5UIW H1 receptor 3RZE
TM6 221 6.34x35 CCR5 5UIW - -
TM6 222 6.35x36 CCR5 5UIW - -
TM6 223 6.36x37 CCR5 5UIW H1 receptor 3RZE
TM6 224 6.37x38 CCR5 5UIW D3 receptor 3PBL
TM6 225 6.38x39 CCR5 5UIW κ receptor 4DJH
TM6 226 6.39x40 CCR5 5UIW κ receptor 4DJH
TM6 227 6.40x41 CCR5 5UIW - -
TM6 228 6.41x42 CCR5 5UIW CXCR4 3ODU
TM6 229 6.42x43 CCR5 5UIW A1 receptor 5UEN
TM6 230 6.43x44 CCR5 5UIW - -
TM6 231 6.44x45 CCR5 5UIW CCR5 5UIW
TM6 232 6.45x46 PAR2 5NDD PAR2 5NDD
TM6 233 6.46x461 PAR2 5NDD P2Y1 receptor 4XNW
TM6 234 6.47x47 PAR2 5NDD PAR2 5NDD
TM6 235 6.48x48 CCR5 5UIW PAR2 5NDD
TM6 236 6.49x49 CCR5 5UIW CB1 receptor 5TGZ
TM6 237 6.50x50 CCR5 5UIW CCR5 5UIW
TM6 238 6.51x51 CCR5 5UIW CCR5 5UIW
TM6 239 6.52x52 CCR5 5UIW CCR5 5UIW
TM6 240 6.53x53 CCR5 5UIW D4 receptor 5WIV
TM6 241 6.54x54 CCR5 5UIW FFA1 receptor 5TZY
TM6 242 6.55x55 CCR5 5UIW D3 receptor 3PBL
TM6 243 6.56x56 CCR5 5UIW CCR5 5UIW
TM6 244 6.57x57 CCR5 5UIW H1 receptor 3RZE
TM6 245 6.58x58 CCR5 5UIW - -
TM6 246 6.59x59 CCR5 5UIW PAR2 5NDD
TM6 247 6.60x60 CCR5 5UIW D3 receptor 3PBL
TM6 248 6.61x61 CCR5 5UIW CCR5 5UIW
ECL3 249 - - - -
ECL3 250 - - - -
ECL3 251 - - - -
ECL3 252 - - - -
TM7 253 7.33x32 CCR5 5UIW A2A receptor 3VG9
TM7 254 7.34x33 CCR5 5UIW CXCR4 3ODU
TM7 255 7.35x34 CCR5 5UIW BLT1 receptor 5X33
TM7 256 7.36x35 CCR5 5UIW CXCR4 3ODU
TM7 257 7.37x36 CCR5 5UIW CXCR4 3ODU
TM7 258 7.38x37 CCR5 5UIW A1 receptor 5UEN
TM7 259 7.39x38 CCR5 5UIW 5-HT2C receptor 6BQH
TM7 260 7.40x39 CCR5 5UIW A2A receptor 3VG9
TM7 261 7.41x40 CCR5 5UIW Rhodopsin 1GZM
TM7 262 7.42x41 CCR5 5UIW apelin receptor 5VBL
TM7 263 7.43x42 CCR5 5UIW ETB receptor 5X93
TM7 264 7.44x43 CCR5 5UIW ETB receptor 5X93
TM7 265 7.45x45 CCR5 5UIW κ receptor 4DJH
TM7 266 7.46x46 CCR5 5UIW Rhodopsin 1GZM
TM7 267 7.47x47 CCR5 5UIW κ receptor 4DJH
TM7 268 7.48x48 CCR5 5UIW κ receptor 4DJH
TM7 269 7.49x49 CCR5 5UIW PAR2 5NDD
TM7 270 7.50x50 CCR5 5UIW CCR5 5UIW
TM7 271 7.51x51 CCR5 5UIW H1 receptor 3RZE
TM7 272 7.52x52 CCR5 5UIW κ receptor 4DJH
TM7 273 7.53x53 CCR5 5UIW - -
TM7 274 7.54x54 CCR5 5UIW ETB receptor 5X93
TM7 275 7.55x55 CCR5 5UIW CCR5 5UIW
TM7 276 7.56x56 CCR5 5UIW 5-HT1B receptor 4IAQ
H8 277 8.47x47 CCR5 5UIW OX2 receptor 5WS3
H8 278 8.48x48 CCR5 5UIW - -
H8 279 8.49x49 CCR5 5UIW - -
H8 280 8.50x50 CCR5 5UIW - -
H8 281 8.51x51 CCR5 5UIW CCR5 5UIW
H8 282 8.52x52 CCR5 5UIW κ receptor 4DJH
H8 283 8.53x53 CCR5 5UIW 5-HT2C receptor 6BQH
H8 284 8.54x54 CCR5 5UIW κ receptor 4DJH
H8 285 8.55x55 CCR5 5UIW 5-HT2B receptor 4IB4
H8 286 8.56x56 CCR5 5UIW 5-HT2B receptor 4IB4
H8 287 8.57x57 CCR5 5UIW - -
H8 288 8.58x58 CCR5 5UIW H1 receptor 3RZE
H8 289 8.59x59 CCR5 5UIW CCR5 5UIW
H8 290 8.60x60 PAF receptor 5ZKP - -
H8 291 8.61x61 PAF receptor 5ZKP CCR9 5LWE
C-term 292 - - - -
C-term 293 - - - -
C-term 294 - - - -
C-term 295 - - - -
C-term 296 - - - -