FSH receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 9.68 docs)

VERSION

2018-07-10

MAIN TEMPLATE

A2A receptor (sequence similarity: 41%) PDB: 5G53

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 74.2 13.7 12.1
Side-chains 17.6 50.3 32.0

Number of backbone templates: 10
Number of rotamer templates: 44

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3P0G
3SN6
5G53
4UHR
2YDV
4N6H
4IAQ
6B73
3VW7
5UEN
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 352 - - - -
N-term 353 - - - -
N-term 354 - - - -
N-term 355 - - - -
N-term 356 - - - -
TM1 357 1.27x27 β2-adrenoceptor 3P0G - -
TM1 358 1.28x28 β2-adrenoceptor 3P0G β2-adrenoceptor 3P0G
TM1 359 1.29x29 β2-adrenoceptor 3P0G NTS1 receptor 5T04
TM1 360 1.30x30 β2-adrenoceptor 3P0G A2A receptor 5IU4
TM1 361 1.31x31 β2-adrenoceptor 3P0G A2A receptor 5IU4
TM1 362 1.32x32 A2A receptor 5G53 - -
TM1 363 1.33x33 A2A receptor 5G53 - -
TM1 364 1.34x34 A2A receptor 5G53 κ receptor 6B73
TM1 365 1.35x35 A2A receptor 5G53 Rhodopsin 5DYS
TM1 366 1.36x36 A2A receptor 5G53 - -
TM1 367 1.37x37 A2A receptor 5G53 CB1 receptor 5XRA
TM1 368 1.38x38 A2A receptor 5G53 μ receptor 5C1M
TM1 369 1.39x39 A2A receptor 5G53 5-HT2C receptor 6BQH
TM1 370 1.40x40 A2A receptor 5G53 CCR9 5LWE
TM1 371 1.41x41 A2A receptor 5G53 M3 receptor 4U15
TM1 372 1.42x42 A2A receptor 5G53 A2A receptor 5G53
TM1 373 1.43x43 A2A receptor 5G53 M2 receptor 4MQT
TM1 374 1.44x44 A2A receptor 5G53 5-HT2B receptor 5TUD
TM1 375 1.45x45 A2A receptor 5G53 A2A receptor 5G53
TM1 376 1.46x46 A2A receptor 5G53 A2A receptor 5G53
TM1 377 1.47x47 A2A receptor 5G53 A2A receptor 5G53
TM1 378 1.48x48 A2A receptor 5G53 M1 receptor 5CXV
TM1 379 1.49x49 A2A receptor 5G53 A2A receptor 5G53
TM1 380 1.50x50 A2A receptor 5G53 A2A receptor 5G53
TM1 381 1.51x51 A2A receptor 5G53 AT2 receptor 5UNG
TM1 382 1.52x52 A2A receptor 5G53 - -
TM1 383 1.53x53 A2A receptor 5G53 A2A receptor 5G53
TM1 384 1.54x54 A2A receptor 5G53 Rhodopsin 5DYS
TM1 385 1.55x55 A2A receptor 5G53 M2 receptor 4MQT
TM1 386 1.56x56 A2A receptor 5G53 LPA6 receptor 5XSZ
TM1 387 1.57x57 A2A receptor 5G53 CCR2 5T1A
TM1 388 1.58x58 A2A receptor 5G53 US28 4XT1
TM1 389 1.59x59 A2A receptor 5G53 D4 receptor 5WIV
TM1 390 1.60x60 A2A receptor 5G53 LPA6 receptor 5XSZ
ICL1 391 - - - -
ICL1 392 12.48x48 A2A receptor 4UHR - -
ICL1 393 12.49x49 A2A receptor 4UHR Rhodopsin 5DYS
ICL1 394 12.50x50 A2A receptor 4UHR A2A receptor 4UHR
ICL1 395 12.51x51 - - - -
TM2 396 2.38x38 A2A receptor 5G53 A2A receptor 5G53
TM2 397 2.39x39 A2A receptor 5G53 ETB receptor 5X93
TM2 398 2.40x40 A2A receptor 5G53 - -
TM2 399 2.41x41 A2A receptor 5G53 - -
TM2 400 2.42x42 A2A receptor 5G53 5-HT1B receptor 6G79
TM2 401 2.43x43 A2A receptor 5G53 PAF receptor 5ZKP
TM2 402 2.44x44 A2A receptor 5G53 - -
TM2 403 2.45x45 A2A receptor 5G53 μ receptor 5C1M
TM2 404 2.46x46 A2A receptor 5G53 A2A receptor 5G53
TM2 405 2.47x47 A2A receptor 5G53 A2A receptor 5G53
TM2 406 2.48x48 A2A receptor 5G53 Y1 receptor 5ZBH
TM2 407 2.49x49 A2A receptor 5G53 A2A receptor 5G53
TM2 408 2.50x50 A2A receptor 5G53 A2A receptor 5G53
TM2 409 2.51x51 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM2 410 2.52x52 A2A receptor 5G53 AT1 receptor 4ZUD
TM2 411 2.53x53 A2A receptor 5G53 M2 receptor 4MQT
TM2 412 2.54x54 A2A receptor 5G53 A2A receptor 5G53
TM2 413 2.55x55 δ receptor 4N6H 5-HT1B receptor 6G79
TM2 414 2.56x56 δ receptor 4N6H - -
TM2 415 2.57x57 A2A receptor 5G53 μ receptor 5C1M
TM2 416 2.58x58 A2A receptor 5G53 - -
TM2 417 2.59x59 A2A receptor 5G53 A1 receptor 6D9H
TM2 418 2.60x60 A2A receptor 5G53 Rhodopsin 5DYS
TM2 419 2.61x61 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM2 420 2.62x62 A2A receptor 5G53 PAR1 3VW7
TM2 421 2.63x63 A2A receptor 5G53 κ receptor 6B73
TM2 422 2.64x64 A2A receptor 5G53 OX2 receptor 5WS3
TM2 423 2.65x65 A2A receptor 5G53 A1 receptor 6D9H
TM2 424 2.66x66 A2A receptor 5G53 Rhodopsin 5DYS
TM2 425 2.67x67 5-HT1B receptor 4IAQ - -
ECL1 426 - - - -
ECL1 427 - - - -
ECL1 428 - - - -
ECL1 429 - - - -
ECL1 430 - - - -
ECL1 431 - - - -
ECL1 432 - - - -
ECL1 433 - - - -
ECL1 434 - - - -
ECL1 435 23.49x49 - - - -
ECL1 436 23.50x50 A2A receptor 5G53 β2-adrenoceptor 4LDE
ECL1 437 23.51x51 A2A receptor 5G53 A1 receptor 6D9H
ECL1 438 23.52x52 A2A receptor 5G53 A1 receptor 6D9H
TM3 439 3.22x22 A2A receptor 5G53 C5a1 receptor 5O9H
TM3 440 3.23x23 A2A receptor 5G53 NTS1 receptor 5T04
TM3 441 3.24x24 A2A receptor 5G53 A2A receptor 5G53
TM3 442 3.25x25 A2A receptor 5G53 A2A receptor 5G53
TM3 443 3.26x26 A2A receptor 5G53 M2 receptor 4MQT
TM3 444 3.27x27 A2A receptor 5G53 5-HT2B receptor 5TUD
TM3 445 3.28x28 A2A receptor 5G53 PAF receptor 5ZKP
TM3 446 3.29x29 A2A receptor 5G53 Rhodopsin 5DYS
TM3 447 3.30x30 A2A receptor 5G53 Rhodopsin 5DYS
TM3 448 3.31x31 A2A receptor 5G53 A2A receptor 5G53
TM3 449 3.32x32 A2A receptor 5G53 - -
TM3 450 3.33x33 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM3 451 3.34x34 A2A receptor 5G53 AT1 receptor 4ZUD
TM3 452 3.35x35 A2A receptor 5G53 US28 4XT1
TM3 453 3.36x36 A2A receptor 5G53 5-HT2B receptor 5TUD
TM3 454 3.37x37 A2A receptor 5G53 Rhodopsin 5DYS
TM3 455 3.38x38 A2A receptor 5G53 - -
TM3 456 3.39x39 A2A receptor 5G53 A2A receptor 5G53
TM3 457 3.40x40 A2A receptor 5G53 M2 receptor 4MQT
TM3 458 3.41x41 A2A receptor 5G53 - -
TM3 459 3.42x42 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM3 460 3.43x43 A2A receptor 5G53 A2A receptor 5G53
TM3 461 3.44x44 A2A receptor 5G53 κ receptor 6B73
TM3 462 3.45x45 A2A receptor 5G53 A2A receptor 5G53
TM3 463 3.46x46 A2A receptor 5G53 A2A receptor 5G53
TM3 464 3.47x47 A2A receptor 5G53 PAF receptor 5ZKP
TM3 465 3.48x48 A2A receptor 5G53 5-HT1B receptor 6G79
TM3 466 3.49x49 A2A receptor 5G53 Rhodopsin 5DYS
TM3 467 3.50x50 A2A receptor 5G53 A2A receptor 5G53
TM3 468 3.51x51 A2A receptor 5G53 OX2 receptor 5WS3
TM3 469 3.52x52 A2A receptor 5G53 - -
TM3 470 3.53x53 A2A receptor 5G53 S1P1 receptor 3V2Y
TM3 471 3.54x54 A2A receptor 5G53 A2A receptor 5G53
TM3 472 3.55x55 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM3 473 3.56x56 A2A receptor 5G53 μ receptor 5C1M
ICL2 474 34.50x50 - - - -
ICL2 475 34.51x51 A2A receptor 4UHR Rhodopsin 4ZWJ
ICL2 476 34.52x52 A2A receptor 4UHR - -
ICL2 477 34.53x53 A2A receptor 4UHR - -
ICL2 478 34.54x54 A2A receptor 4UHR - -
ICL2 479 34.55x55 A2A receptor 4UHR - -
ICL2 480 34.56x56 A2A receptor 4UHR 5-HT1B receptor 6G79
ICL2 481 34.57x57 - - - -
TM4 482 4.38x38 A2A receptor 5G53 - -
TM4 483 4.39x39 A2A receptor 5G53 PAR1 3VW7
TM4 484 4.40x40 A2A receptor 5G53 A1 receptor 6D9H
TM4 485 4.41x41 A2A receptor 5G53 Rhodopsin 5DYS
TM4 486 4.42x42 A2A receptor 5G53 A2A receptor 5G53
TM4 487 4.43x43 A2A receptor 5G53 A1 receptor 6D9H
TM4 488 4.44x44 A2A receptor 5G53 PAF receptor 5ZKQ
TM4 489 4.45x45 A2A receptor 5G53 μ receptor 5C1M
TM4 490 4.46x46 A2A receptor 5G53 - -
TM4 491 4.47x47 A2A receptor 5G53 μ receptor 5C1M
TM4 492 4.48x48 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM4 493 4.49x49 A2A receptor 5G53 - -
TM4 494 4.50x50 A2A receptor 5G53 A2A receptor 5G53
TM4 495 4.51x51 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM4 496 4.52x52 A2A receptor 5G53 5-HT1B receptor 6G79
TM4 497 4.53x53 A2A receptor 5G53 Rhodopsin 5DYS
TM4 498 4.54x54 A2A receptor 5G53 A2A receptor 5G53
TM4 499 4.55x55 A2A receptor 5G53 A2A receptor 5G53
TM4 500 4.56x56 A2A receptor 5G53 PAF receptor 5ZKP
TM4 501 4.57x57 A2A receptor 5G53 Rhodopsin 5DYS
TM4 502 4.58x58 A2A receptor 5G53 A2A receptor 5G53
TM4 503 4.59x59 A2A receptor 5G53 - -
TM4 504 4.60x60 A2A receptor 5G53 A2A receptor 5G53
TM4 505 4.61x61 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM4 506 4.62x62 A2A receptor 5G53 A1 receptor 6D9H
TM4 507 4.63x63 A2A receptor 5G53 A2A receptor 5G53
ECL2 508 - - - -
ECL2 509 κ receptor 6B73 - -
ECL2 510 κ receptor 6B73 - -
ECL2 511 κ receptor 6B73 - -
ECL2 512 κ receptor 6B73 - -
ECL2 513 - - - -
ECL2 514 - - - -
ECL2 515 - - - -
ECL2 516 - - - -
ECL2 517 45.50x50 A2A receptor 5G53 A2A receptor 5G53
ECL2 518 45.51x51 A2A receptor 5G53 A2A receptor 5G53
ECL2 519 45.52x52 A2A receptor 5G53 - -
ECL2 520 - - - -
ECL2 521 δ receptor 4N6H - -
ECL2 522 δ receptor 4N6H - -
ECL2 523 δ receptor 4N6H - -
ECL2 524 - - - -
TM5 525 5.34x34 δ receptor 4N6H - -
TM5 526 5.35x35 δ receptor 4N6H AT1 receptor 4ZUD
TM5 527 5.36x36 A2A receptor 5G53 A1 receptor 6D9H
TM5 528 5.37x37 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM5 529 5.38x38 A2A receptor 5G53 μ receptor 5C1M
TM5 530 5.39x39 A2A receptor 5G53 A2A receptor 5G53
TM5 531 5.40x40 A2A receptor 5G53 Rhodopsin 5DYS
TM5 532 5.41x41 β2-adrenoceptor 3SN6 CB1 receptor 5XRA
TM5 533 5.42x42 β2-adrenoceptor 3SN6 PAR2 5NDD
TM5 534 5.43x43 A2A receptor 5G53 US28 4XT1
TM5 535 5.44x44 A2A receptor 5G53 Y1 receptor 5ZBH
TM5 536 5.45x45 A2A receptor 5G53 Rhodopsin 5DYS
TM5 537 5.46x46 PAR1 3VW7 AT2 receptor 5UNG
TM5 538 5.47x47 PAR1 3VW7 LPA1 receptor 4Z35
TM5 539 5.48x48 A2A receptor 5G53 κ receptor 6B73
TM5 540 5.49x49 A2A receptor 5G53 M2 receptor 4MQT
TM5 541 5.50x50 A2A receptor 5G53 - -
TM5 542 5.51x51 A2A receptor 5G53 PAF receptor 5ZKP
TM5 543 5.52x52 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM5 544 5.53x53 A2A receptor 5G53 Rhodopsin 5DYS
TM5 545 5.54x54 A2A receptor 5G53 μ receptor 5C1M
TM5 546 5.55x55 A2A receptor 5G53 M1 receptor 5CXV
TM5 547 5.56x56 A2A receptor 5G53 A2A receptor 5G53
TM5 548 5.57x57 A2A receptor 5G53 μ receptor 5C1M
TM5 549 5.58x58 A2A receptor 5G53 A2A receptor 5G53
TM5 550 5.59x59 A2A receptor 5G53 D2 receptor 6CM4
TM5 551 5.60x60 A2A receptor 5G53 M2 receptor 4MQT
TM5 552 5.61x61 A2A receptor 5G53 A2A receptor 5G53
TM5 553 5.62x62 A2A receptor 5G53 5-HT1B receptor 6G79
TM5 554 5.63x63 A2A receptor 5G53 A2A receptor 5G53
TM5 555 5.64x64 A2A receptor 5G53 Rhodopsin 5DYS
TM5 556 5.65x65 A2A receptor 5G53 Rhodopsin 5DYS
TM5 557 5.66x66 A2A receptor 5G53 A2A receptor 5G53
TM5 558 5.67x67 A2A receptor 5G53 - -
ICL3 559 - - - -
ICL3 560 - - - -
ICL3 561 - - - -
ICL3 562 - - - -
TM6 563 6.26x26 A2A receptor 5G53 - -
TM6 564 6.27x27 A2A receptor 5G53 PAR2 5NDD
TM6 565 6.28x28 A2A receptor 5G53 5-HT2B receptor 5TUD
TM6 566 6.29x29 A2A receptor 5G53 δ receptor 4N6H
TM6 567 6.30x30 A2A receptor 5G53 CB1 receptor 5XRA
TM6 568 6.31x31 A2A receptor 5G53 C5a1 receptor 6C1R
TM6 569 6.32x32 A2A receptor 5G53 μ receptor 5C1M
TM6 570 6.33x33 A2A receptor 5G53 A1 receptor 6D9H
TM6 571 6.34x34 A2A receptor 5G53 A2A receptor 5G53
TM6 572 6.35x35 A2A receptor 5G53 A2A receptor 5G53
TM6 573 6.36x36 A2A receptor 5G53 - -
TM6 574 6.37x37 A2A receptor 5G53 PAF receptor 5ZKP
TM6 575 6.38x38 A2A receptor 5G53 A2A receptor 5G53
TM6 576 6.39x39 A2A receptor 5G53 - -
TM6 577 6.40x40 A2A receptor 5G53 apelin receptor 5VBL
TM6 578 6.41x41 A2A receptor 5G53 CXCR4 3ODU
TM6 579 6.42x42 A2A receptor 5G53 A1 receptor 6D9H
TM6 580 6.43x43 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM6 581 6.44x44 A2A receptor 5G53 - -
TM6 582 6.45x45 A2A receptor 5G53 PAF receptor 5ZKP
TM6 583 6.46x46 A2A receptor 5G53 A2A receptor 5G53
TM6 584 6.47x47 A2A receptor 5G53 A2A receptor 5G53
TM6 585 6.48x48 A2A receptor 5G53 - -
TM6 586 6.49x49 A2A receptor 5G53 M2 receptor 4MQT
TM6 587 6.50x50 A2A receptor 5G53 A2A receptor 5G53
TM6 588 6.51x51 A2A receptor 5G53 μ receptor 5C1M
TM6 589 6.52x52 A2A receptor 5G53 OX2 receptor 5WS3
TM6 590 6.53x53 A2A receptor 5G53 P2Y12 receptor 4NTJ
TM6 591 6.54x54 A2A receptor 5G53 κ receptor 6B73
TM6 592 6.55x55 A2A receptor 5G53 Rhodopsin 5DYS
TM6 593 6.56x56 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM6 594 6.57x57 A2A receptor 5G53 - -
TM6 595 6.58x58 A2A receptor 5G53 - -
TM6 596 6.59x59 A2A receptor 5G53 LPA6 receptor 5XSZ
TM6 597 6.60x60 A2A receptor 5G53 μ receptor 5C1M
TM6 598 6.61x61 A2A receptor 5G53 - -
ECL3 599 - - - -
ECL3 600 A1 receptor 5UEN - -
ECL3 601 A1 receptor 5UEN - -
ECL3 602 A1 receptor 5UEN - -
ECL3 603 - - - -
TM7 604 7.31x30 A2A receptor 5G53 - -
TM7 605 7.32x31 A2A receptor 5G53 A1 receptor 6D9H
TM7 606 7.33x32 A2A receptor 5G53 5-HT2C receptor 6BQH
TM7 607 7.34x33 A2A receptor 5G53 AT2 receptor 5UNG
TM7 608 7.35x34 A2A receptor 5G53 P2Y12 receptor 4NTJ
TM7 609 7.36x35 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM7 610 7.37x36 A2A receptor 5G53 A2A receptor 5G53
TM7 611 7.38x37 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM7 612 7.39x38 A2A receptor 5G53 5-HT2B receptor 5TUD
TM7 613 7.40x39 A2A receptor 5G53 AT2 receptor 5UNG
TM7 614 7.41x40 A2A receptor 5G53 Rhodopsin 5DYS
TM7 615 7.42x41 A2A receptor 5G53 - -
TM7 616 7.43x42 A2A receptor 5G53 - -
TM7 617 7.44x43 A2A receptor 5G53 M2 receptor 4MQT
TM7 618 7.45x45 A2A receptor 5G53 A2A receptor 5G53
TM7 619 7.46x46 A2A receptor 5G53 A2A receptor 5G53
TM7 620 7.47x47 A2A receptor 5G53 μ receptor 5C1M
TM7 621 7.48x48 A2A receptor 5G53 OX2 receptor 5WS3
TM7 622 7.49x49 A2A receptor 5G53 A2A receptor 5G53
TM7 623 7.50x50 A2A receptor 5G53 A2A receptor 5G53
TM7 624 7.51x51 A2A receptor 5G53 A2A receptor 5G53
TM7 625 7.52x52 A2A receptor 5G53 μ receptor 6DDF
TM7 626 7.53x53 A2A receptor 5G53 A2A receptor 5G53
TM7 627 7.54x54 A2A receptor 5G53 A2A receptor 5G53
TM7 628 7.55x55 A2A receptor 5G53 - -
TM7 629 7.56x56 A2A receptor 5G53 5-HT2C receptor 6BQG
H8 630 8.47x47 A2A receptor 5G53 - -
H8 631 8.48x48 A2A receptor 5G53 Rhodopsin 5DYS
H8 632 8.49x49 A2A receptor 5G53 δ receptor 4N6H
H8 633 8.50x50 A2A receptor 5G53 A2A receptor 5G53
H8 634 8.51x51 A2A receptor 5G53 A2A receptor 5G53
H8 635 8.52x52 A2A receptor 5G53 5-HT2C receptor 6BQG
H8 636 8.53x53 A2A receptor 5G53 Y1 receptor 5ZBH
H8 637 8.54x54 A2A receptor 5G53 A2A receptor 5G53
H8 638 8.55x55 A2A receptor 5G53 - -
H8 639 8.56x56 A2A receptor 5G53 - -
H8 640 8.57x57 A2A receptor 5G53 β2-adrenoceptor 3SN6
H8 641 8.58x58 A2A receptor 5G53 β2-adrenoceptor 3SN6
H8 642 8.59x59 A2A receptor 5G53 OX2 receptor 5WS3
H8 643 8.60x60 A2A receptor 5G53 - -
H8 644 8.61x61 A2A receptor 2YDV OX2 receptor 5WS3
H8 645 8.62x62 A2A receptor 2YDV CCR9 5LWE
H8 646 8.63x63 A2A receptor 2YDV - -
H8 647 8.64x64 A2A receptor 2YDV - -
H8 648 8.65x65 A2A receptor 2YDV - -
H8 649 8.66x66 A2A receptor 2YDV - -
H8 650 8.67x67 A2A receptor 2YDV - -
H8 651 8.68x68 A2A receptor 2YDV - -
H8 652 8.69x69 A2A receptor 2YDV - -
C-term 653 - - - -
C-term 654 - - - -
C-term 655 - - - -
C-term 656 - - - -
C-term 657 - - - -