GPR119 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate (Δ distance (Å): 6.23 docs)

VERSION

2018-07-10

MAIN TEMPLATE

A2A receptor (sequence similarity: 38%) PDB: 4UHR

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 82.7 9.3 8.0
Side-chains 25.9 49.2 24.9

Number of backbone templates: 7
Number of rotamer templates: 45

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5CXV
4UHR
5VBL
4Z35
4PXZ
6BQH
5UEN
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
TM1 1 1.29x29 M1 receptor 5CXV μ receptor 5C1M
TM1 2 1.30x30 M1 receptor 5CXV - -
TM1 3 1.31x31 M1 receptor 5CXV NTS1 receptor 4XES
TM1 4 1.32x32 A2A receptor 4UHR A2A receptor 4UHR
TM1 5 1.33x33 A2A receptor 4UHR Y1 receptor 5ZBH
TM1 6 1.34x34 A2A receptor 4UHR - -
TM1 7 1.35x35 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM1 8 1.36x36 A2A receptor 4UHR M1 receptor 5CXV
TM1 9 1.37x37 A2A receptor 4UHR D4 receptor 5WIV
TM1 10 1.38x38 A2A receptor 4UHR NTS1 receptor 4XES
TM1 11 1.39x39 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM1 12 1.40x40 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM1 13 1.41x41 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM1 14 1.42x42 A2A receptor 4UHR NTS1 receptor 4XES
TM1 15 1.43x43 A2A receptor 4UHR A2A receptor 4UHR
TM1 16 1.44x44 A2A receptor 4UHR - -
TM1 17 1.45x45 A2A receptor 4UHR A2A receptor 4UHR
TM1 18 1.46x46 A2A receptor 4UHR β2-adrenoceptor 3SN6
TM1 19 1.47x47 A2A receptor 4UHR A2A receptor 4UHR
TM1 20 1.48x48 A2A receptor 4UHR D4 receptor 5WIV
TM1 21 1.49x49 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM1 22 1.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM1 23 1.51x51 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM1 24 1.52x52 A2A receptor 4UHR A2A receptor 4UHR
TM1 25 1.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM1 26 1.54x54 A2A receptor 4UHR - -
TM1 27 1.55x55 A2A receptor 4UHR PAR1 3VW7
TM1 28 1.56x56 A2A receptor 4UHR A2A receptor 4UHR
TM1 29 1.57x57 A2A receptor 4UHR A2A receptor 4UHR
TM1 30 1.58x58 A2A receptor 4UHR PAR2 5NDD
TM1 31 1.59x59 A2A receptor 4UHR A2A receptor 4UHR
TM1 32 1.60x60 A2A receptor 4UHR PAF receptor 5ZKQ
ICL1 33 - - - -
ICL1 34 apelin receptor 5VBL - -
ICL1 35 apelin receptor 5VBL - -
ICL1 36 apelin receptor 5VBL - -
ICL1 37 - - - -
TM2 38 2.37x37 A2A receptor 4UHR - -
TM2 39 2.38x38 A2A receptor 4UHR A2A receptor 4UHR
TM2 40 2.39x39 A2A receptor 4UHR FFA1 receptor 5TZY
TM2 41 2.40x40 A2A receptor 4UHR - -
TM2 42 2.41x41 A2A receptor 4UHR A1 receptor 5UEN
TM2 43 2.42x42 A2A receptor 4UHR A2A receptor 4UHR
TM2 44 2.43x43 A2A receptor 4UHR - -
TM2 45 2.44x44 A2A receptor 4UHR PAR1 3VW7
TM2 46 2.45x45 A2A receptor 4UHR μ receptor 6DDE
TM2 47 2.46x46 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM2 48 2.47x47 A2A receptor 4UHR A2A receptor 4UHR
TM2 49 2.48x48 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM2 50 2.49x49 A2A receptor 4UHR A2A receptor 4UHR
TM2 51 2.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM2 52 2.51x51 A2A receptor 4UHR NOP receptor 5DHG
TM2 53 2.52x52 A2A receptor 4UHR A2A receptor 4UHR
TM2 54 2.53x53 A2A receptor 4UHR NTS1 receptor 4XES
TM2 55 2.54x54 A2A receptor 4UHR A2A receptor 4UHR
TM2 56 2.55x55 LPA1 receptor 4Z35 A2A receptor 4UHR
TM2 57 2.56x56 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM2 58 2.57x57 A2A receptor 4UHR A2A receptor 4UHR
TM2 59 2.58x58 A2A receptor 4UHR - -
TM2 60 2.59x59 A2A receptor 4UHR - -
TM2 61 2.60x60 A2A receptor 4UHR P2Y1 receptor 4XNW
TM2 62 2.61x61 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM2 63 2.62x62 A2A receptor 4UHR A2A receptor 3QAK
TM2 64 2.63x63 A2A receptor 4UHR CB1 receptor 5XRA
TM2 65 2.64x64 A2A receptor 4UHR - -
TM2 66 2.65x65 A2A receptor 4UHR FFA1 receptor 5TZY
TM2 67 2.66x66 A2A receptor 4UHR PAR1 3VW7
ECL1 68 A2A receptor 4UHR A2A receptor 4UHR
ECL1 69 A2A receptor 4UHR A2A receptor 4UHR
ECL1 70 A2A receptor 4UHR A2A receptor 4UHR
TM3 71 3.18x18 P2Y12 receptor 4PXZ - -
TM3 72 3.19x19 P2Y12 receptor 4PXZ P2Y12 receptor 4PXZ
TM3 73 3.20x20 P2Y12 receptor 4PXZ - -
TM3 74 3.21x21 A2A receptor 4UHR - -
TM3 75 3.22x22 A2A receptor 4UHR PAF receptor 5ZKQ
TM3 76 3.23x23 A2A receptor 4UHR CCR5 5UIW
TM3 77 3.24x24 A2A receptor 4UHR 5-HT2B receptor 4NC3
TM3 78 3.25x25 A2A receptor 4UHR A2A receptor 4UHR
TM3 79 3.26x26 A2A receptor 4UHR C5a1 receptor 5O9H
TM3 80 3.27x27 A2A receptor 4UHR P2Y1 receptor 4XNW
TM3 81 3.28x28 A2A receptor 4UHR LPA1 receptor 4Z35
TM3 82 3.29x29 A2A receptor 4UHR D4 receptor 5WIV
TM3 83 3.30x30 A2A receptor 4UHR PAR1 3VW7
TM3 84 3.31x31 A2A receptor 4UHR A2A receptor 4UHR
TM3 85 3.32x32 A2A receptor 4UHR A2A receptor 4UHR
TM3 86 3.33x33 A2A receptor 4UHR CB1 receptor 5XRA
TM3 87 3.34x34 A2A receptor 4UHR - -
TM3 88 3.35x35 A2A receptor 4UHR LPA1 receptor 4Z35
TM3 89 3.36x36 A2A receptor 4UHR A1 receptor 5N2S
TM3 90 3.37x37 A2A receptor 4UHR A2A receptor 4UHR
TM3 91 3.38x38 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM3 92 3.39x39 A2A receptor 4UHR A2A receptor 4UHR
TM3 93 3.40x40 A2A receptor 4UHR PAF receptor 5ZKQ
TM3 94 3.41x41 A2A receptor 4UHR PAR2 5NDD
TM3 95 3.42x42 A2A receptor 4UHR μ receptor 6DDE
TM3 96 3.43x43 A2A receptor 4UHR NTS1 receptor 4XES
TM3 97 3.44x44 A2A receptor 4UHR CCR9 5LWE
TM3 98 3.45x45 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM3 99 3.46x46 A2A receptor 4UHR A2A receptor 4UHR
TM3 100 3.47x47 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM3 101 3.48x48 A2A receptor 4UHR M1 receptor 5CXV
TM3 102 3.49x49 A2A receptor 4UHR A2A receptor 4UHR
TM3 103 3.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM3 104 3.51x51 A2A receptor 4UHR A2A receptor 4UHR
TM3 105 3.52x52 A2A receptor 4UHR PAR1 3VW7
TM3 106 3.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM3 107 3.54x54 A2A receptor 4UHR A2A receptor 4UHR
TM3 108 3.55x55 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM3 109 3.56x56 A2A receptor 4UHR H1 receptor 3RZE
ICL2 110 34.50x50 - - - -
ICL2 111 34.51x51 M1 receptor 5CXV NTS1 receptor 4XES
ICL2 112 34.52x52 M1 receptor 5CXV A2A receptor 4UHR
ICL2 113 34.53x53 M1 receptor 5CXV M1 receptor 5CXV
ICL2 114 34.54x54 M1 receptor 5CXV μ receptor 6DDE
ICL2 115 34.55x55 M1 receptor 5CXV BLT1 receptor 5X33
ICL2 116 34.56x56 M1 receptor 5CXV CB1 receptor 5XRA
ICL2 117 34.57x57 - - - -
TM4 118 4.38x38 A2A receptor 4UHR 5-HT2B receptor 5TVN
TM4 119 4.39x39 A2A receptor 4UHR A2A receptor 4UHR
TM4 120 4.40x40 A2A receptor 4UHR S1P1 receptor 3V2Y
TM4 121 4.41x41 A2A receptor 4UHR AT1 receptor 4ZUD
TM4 122 4.42x42 A2A receptor 4UHR A2A receptor 4UHR
TM4 123 4.43x43 A2A receptor 4UHR M3 receptor 4U15
TM4 124 4.44x44 A2A receptor 4UHR H1 receptor 3RZE
TM4 125 4.45x45 A2A receptor 4UHR - -
TM4 126 4.46x46 A2A receptor 4UHR A2A receptor 4UHR
TM4 127 4.47x47 A2A receptor 4UHR A2A receptor 4UHR
TM4 128 4.48x48 A2A receptor 4UHR H1 receptor 3RZE
TM4 129 4.49x49 A2A receptor 4UHR apelin receptor 5VBL
TM4 130 4.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM4 131 4.51x51 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM4 132 4.52x52 A2A receptor 4UHR M1 receptor 5CXV
TM4 133 4.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM4 134 4.54x54 A2A receptor 4UHR - -
TM4 135 4.55x55 A2A receptor 4UHR PAR2 5NDD
TM4 136 4.56x56 A2A receptor 4UHR A2A receptor 4UHR
TM4 137 4.57x57 A2A receptor 4UHR A2A receptor 4UHR
TM4 138 4.58x58 A2A receptor 4UHR β2-adrenoceptor 3SN6
TM4 139 4.59x59 A2A receptor 4UHR FFA1 receptor 5TZY
TM4 140 4.60x60 A2A receptor 4UHR A2A receptor 4UHR
TM4 141 4.61x61 A2A receptor 4UHR PAR2 5NDD
TM4 142 4.62x62 A2A receptor 4UHR FFA1 receptor 5TZY
TM4 143 4.63x63 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM4 144 4.64x64 M1 receptor 5CXV - -
TM4 145 4.65x65 M1 receptor 5CXV - -
TM4 146 4.66x66 M1 receptor 5CXV M2 receptor 3UON
TM4 147 4.67x67 M1 receptor 5CXV - -
TM4 148 4.68x68 M1 receptor 5CXV - -
TM4 149 4.69x69 M1 receptor 5CXV - -
ECL2 150 - - - -
ECL2 151 - - - -
ECL2 152 - - - -
ECL2 153 - - - -
ECL2 154 - - - -
ECL2 155 45.50x50 A2A receptor 4UHR A2A receptor 4UHR
ECL2 156 45.51x51 A2A receptor 4UHR D3 receptor 3PBL
ECL2 157 45.52x52 A2A receptor 4UHR A2A receptor 4UHR
ECL2 158 - - - -
ECL2 159 - - - -
ECL2 160 - - - -
TM5 161 5.35x36 A2A receptor 4UHR 5-HT2B receptor 5TUD
TM5 162 5.36x37 A2A receptor 4UHR - -
TM5 163 5.37x38 A2A receptor 4UHR FFA1 receptor 5TZY
TM5 164 5.38x39 A2A receptor 4UHR BLT1 receptor 5X33
TM5 165 5.39x40 A2A receptor 4UHR PAR2 5NDD
TM5 166 5.40x41 5-HT2C receptor 6BQH A2A receptor 4UHR
TM5 167 5.41x42 5-HT2C receptor 6BQH Y1 receptor 5ZBH
TM5 168 5.42x43 A2A receptor 4UHR P2Y1 receptor 4XNW
TM5 169 5.43x44 A2A receptor 4UHR C5a1 receptor 5O9H
TM5 170 5.44x45 A2A receptor 4UHR ETB receptor 5X93
TM5 171 5.45x46 A2A receptor 4UHR D4 receptor 5WIV
TM5 172 5.46x461 A2A receptor 4UHR PAR2 5NDD
TM5 173 5.47x47 A2A receptor 4UHR - -
TM5 174 5.48x48 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM5 175 5.49x49 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM5 176 5.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM5 177 5.51x51 A2A receptor 4UHR PAR2 5NDD
TM5 178 5.52x52 A2A receptor 4UHR - -
TM5 179 5.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM5 180 5.54x54 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM5 181 5.55x55 A2A receptor 4UHR Y1 receptor 5ZBH
TM5 182 5.56x56 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM5 183 5.57x57 A2A receptor 4UHR H1 receptor 3RZE
TM5 184 5.58x58 A2A receptor 4UHR FFA1 receptor 5TZY
TM5 185 5.59x59 A2A receptor 4UHR US28 4XT1
TM5 186 5.60x60 A2A receptor 4UHR - -
TM5 187 5.61x61 A2A receptor 4UHR - -
TM5 188 5.62x62 A2A receptor 4UHR - -
TM5 189 5.63x63 A2A receptor 4UHR A2A receptor 4UHR
TM5 190 5.64x64 A2A receptor 4UHR NTS1 receptor 4XES
TM5 191 5.65x65 A2A receptor 4UHR A1 receptor 5UEN
TM5 192 5.66x66 A2A receptor 4UHR FFA1 receptor 5TZY
TM5 193 5.67x67 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM5 194 5.68x68 A2A receptor 4UHR NTS1 receptor 4XES
TM5 195 5.69x69 A2A receptor 4UHR - -
TM5 196 5.70x70 A2A receptor 4UHR - -
TM5 197 5.71x71 A2A receptor 4UHR A2A receptor 4UHR
TM5 198 5.72x72 A2A receptor 4UHR Rhodopsin 6CMO
TM5 199 5.73x73 A2A receptor 4UHR - -
TM5 200 5.74x74 A2A receptor 4UHR - -
ICL3 201 - - - -
ICL3 202 - - - -
ICL3 203 - - - -
ICL3 204 - - - -
ICL3 205 - - - -
ICL3 206 - - - -
ICL3 207 - - - -
ICL3 208 - - - -
ICL3 209 - - - -
ICL3 210 - - - -
TM6 211 6.21x21 A2A receptor 4UHR - -
TM6 212 6.22x22 A2A receptor 4UHR - -
TM6 213 6.23x23 A2A receptor 4UHR - -
TM6 214 6.24x24 A2A receptor 4UHR - -
TM6 215 6.25x25 A2A receptor 4UHR - -
TM6 216 6.26x26 A2A receptor 4UHR NTS1 receptor 4BUO
TM6 217 6.27x27 A2A receptor 4UHR FFA1 receptor 5TZY
TM6 218 6.28x28 A2A receptor 4UHR - -
TM6 219 6.29x29 A2A receptor 4UHR PAR1 3VW7
TM6 220 6.30x30 A2A receptor 4UHR CB1 receptor 5XRA
TM6 221 6.31x31 A2A receptor 4UHR - -
TM6 222 6.32x32 A2A receptor 4UHR 5-HT1B receptor 4IAR
TM6 223 6.33x33 A2A receptor 4UHR A2A receptor 4UHR
TM6 224 6.34x34 A2A receptor 4UHR β2-adrenoceptor 5JQH
TM6 225 6.35x35 A2A receptor 4UHR μ receptor 6DDE
TM6 226 6.36x36 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM6 227 6.37x37 A2A receptor 4UHR μ receptor 6DDE
TM6 228 6.38x38 A2A receptor 4UHR PAR1 3VW7
TM6 229 6.39x39 A2A receptor 4UHR μ receptor 6DDE
TM6 230 6.40x40 A2A receptor 4UHR apelin receptor 5VBL
TM6 231 6.41x41 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM6 232 6.42x42 A2A receptor 4UHR A2A receptor 4UHR
TM6 233 6.43x43 A2A receptor 4UHR C5a1 receptor 5O9H
TM6 234 6.44x44 A2A receptor 4UHR A2A receptor 4UHR
TM6 235 6.45x45 A2A receptor 4UHR A2A receptor 4UHR
TM6 236 6.46x46 A2A receptor 4UHR A2A receptor 4UHR
TM6 237 6.47x47 A2A receptor 4UHR P2Y1 receptor 4XNW
TM6 238 6.48x48 A2A receptor 4UHR A2A receptor 4UHR
TM6 239 6.49x49 A2A receptor 4UHR PAR2 5NDD
TM6 240 6.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM6 241 6.51x51 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM6 242 6.52x52 A2A receptor 4UHR LPA1 receptor 4Z35
TM6 243 6.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM6 244 6.54x54 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM6 245 6.55x55 A2A receptor 4UHR FFA1 receptor 5KW2
TM6 246 6.56x56 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM6 247 6.57x57 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM6 248 6.58x58 A2A receptor 4UHR D4 receptor 5WIV
TM6 249 6.59x59 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM6 250 6.60x60 A2A receptor 4UHR - -
TM6 251 6.61x61 A2A receptor 4UHR A2A receptor 4UHR
ECL3 252 - - - -
ECL3 253 A1 receptor 5UEN - -
ECL3 254 A1 receptor 5UEN A1 receptor 5UEN
ECL3 255 A1 receptor 5UEN A1 receptor 5UEN
ECL3 256 - - - -
TM7 257 7.31x30 A2A receptor 4UHR - -
TM7 258 7.32x31 A2A receptor 4UHR A2A receptor 4UHR
TM7 259 7.33x32 A2A receptor 4UHR μ receptor 6DDE
TM7 260 7.34x33 A2A receptor 4UHR A2A receptor 4UHR
TM7 261 7.35x34 A2A receptor 4UHR LPA1 receptor 4Z35
TM7 262 7.36x35 A2A receptor 4UHR NOP receptor 5DHG
TM7 263 7.37x36 A2A receptor 4UHR S1P1 receptor 3V2Y
TM7 264 7.38x37 A2A receptor 4UHR β2-adrenoceptor 3SN6
TM7 265 7.39x38 A2A receptor 4UHR - -
TM7 266 7.40x39 A2A receptor 4UHR LPA1 receptor 4Z35
TM7 267 7.41x40 A2A receptor 4UHR A2A receptor 4UHR
TM7 268 7.42x41 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM7 269 7.43x42 A2A receptor 4UHR S1P1 receptor 3V2Y
TM7 270 7.44x43 A2A receptor 4UHR A1 receptor 5UEN
TM7 271 7.45x45 A2A receptor 4UHR A2A receptor 4UHR
TM7 272 7.46x46 A2A receptor 4UHR A2A receptor 4UHR
TM7 273 7.47x47 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM7 274 7.48x48 A2A receptor 4UHR μ receptor 6DDE
TM7 275 7.49x49 A2A receptor 4UHR A2A receptor 4UHR
TM7 276 7.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM7 277 7.51x51 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM7 278 7.52x52 A2A receptor 4UHR A2A receptor 4UHR
TM7 279 7.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM7 280 7.54x54 A2A receptor 4UHR A2A receptor 4UHR
TM7 281 7.55x55 A2A receptor 4UHR A2A receptor 4UHR
TM7 282 7.56x56 A2A receptor 4UHR - -
H8 283 8.47x47 A2A receptor 4UHR - -
H8 284 8.48x48 A2A receptor 4UHR 5-HT2B receptor 5TVN
H8 285 8.49x49 A2A receptor 4UHR A2A receptor 4UHR
H8 286 8.50x50 A2A receptor 4UHR - -
H8 287 8.51x51 A2A receptor 4UHR A2A receptor 4UHR
H8 288 8.52x52 A2A receptor 4UHR - -
H8 289 8.53x53 A2A receptor 4UHR OX1 receptor 4ZJ8
H8 290 8.54x54 A2A receptor 4UHR Y1 receptor 5ZBH
H8 291 8.55x55 A2A receptor 4UHR - -
H8 292 8.56x56 A2A receptor 4UHR M2 receptor 3UON
H8 293 8.57x57 A2A receptor 4UHR CB1 receptor 5XRA
H8 294 8.58x58 A2A receptor 4UHR - -
H8 295 8.59x59 A2A receptor 4UHR M1 receptor 5CXV
C-term 296 A2A receptor 4UHR A2A receptor 4UHR
C-term 297 A2A receptor 4UHR A2A receptor 4UHR
C-term 298 A2A receptor 4UHR A2A receptor 4UHR
C-term 299 A2A receptor 4UHR A2A receptor 4UHR
C-term 300 A2A receptor 4UHR A2A receptor 4UHR
C-term 301 A2A receptor 4UHR A2A receptor 4UHR