GPR146 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive (Δ distance (Å): -0.83 docs)

VERSION

2018-07-10

MAIN TEMPLATE

AT1 receptor (sequence similarity: 35%) PDB: 4ZUD

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 74.3 13.0 12.7
Side-chains 14.0 51.7 34.3

Number of backbone templates: 8
Number of rotamer templates: 36

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4ZUD
4YAY
5WIV
5WS3
5XSZ
4N6H
3ODU
5LWE
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 20 AT1 receptor 4ZUD AT1 receptor 4ZUD
N-term 21 AT1 receptor 4ZUD AT1 receptor 4ZUD
N-term 22 AT1 receptor 4ZUD AT1 receptor 4ZUD
N-term 23 AT1 receptor 4ZUD AT1 receptor 4ZUD
N-term 24 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM1 25 1.30x30 AT1 receptor 4ZUD NOP receptor 5DHG
TM1 26 1.31x31 AT1 receptor 4ZUD δ receptor 4N6H
TM1 27 1.32x32 AT1 receptor 4ZUD CCR9 5LWE
TM1 28 1.33x33 AT1 receptor 4ZUD BLT1 receptor 5X33
TM1 29 1.34x34 AT1 receptor 4ZUD BLT1 receptor 5X33
TM1 30 1.35x35 AT1 receptor 4ZUD FFA1 receptor 5TZY
TM1 31 1.36x36 AT1 receptor 4ZUD D4 receptor 5WIV
TM1 32 1.37x37 AT1 receptor 4ZUD Y1 receptor 5ZBH
TM1 33 1.38x38 AT1 receptor 4ZUD D4 receptor 5WIV
TM1 34 1.39x39 AT1 receptor 4ZUD BLT1 receptor 5X33
TM1 35 1.40x40 AT1 receptor 4ZUD D4 receptor 5WIV
TM1 36 1.41x41 AT1 receptor 4ZUD κ receptor 4DJH
TM1 37 1.42x42 AT1 receptor 4ZUD - -
TM1 38 1.43x43 AT1 receptor 4ZUD β2-adrenoceptor 5JQH
TM1 39 1.44x44 AT1 receptor 4ZUD - -
TM1 40 1.45x45 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM1 41 1.46x46 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM1 42 1.47x47 AT1 receptor 4ZUD δ receptor 4N6H
TM1 43 1.48x48 AT1 receptor 4ZUD - -
TM1 44 1.49x49 AT1 receptor 4ZUD - -
TM1 45 1.50x50 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM1 46 1.51x51 AT1 receptor 4ZUD C5a1 receptor 5O9H
TM1 47 1.52x52 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM1 48 1.53x53 AT1 receptor 4ZUD Y1 receptor 5ZBH
TM1 49 1.54x54 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM1 50 1.55x55 AT1 receptor 4ZUD CXCR4 3ODU
TM1 51 1.56x56 AT1 receptor 4ZUD OX2 receptor 5WS3
TM1 52 1.57x57 AT1 receptor 4ZUD - -
TM1 53 1.58x58 AT1 receptor 4ZUD NOP receptor 5DHG
TM1 54 1.59x59 AT1 receptor 4ZUD CB1 receptor 5TGZ
TM1 55 1.60x60 AT1 receptor 4ZUD CB1 receptor 5XRA
ICL1 56 - - - -
ICL1 57 - - - -
ICL1 58 - - - -
ICL1 59 - - - -
ICL1 60 - - - -
ICL1 61 - - - -
ICL1 62 - - - -
ICL1 63 - - - -
ICL1 64 - - - -
TM2 65 2.37x37 AT1 receptor 4ZUD 5-HT2B receptor 4IB4
TM2 66 2.38x38 AT1 receptor 4ZUD - -
TM2 67 2.39x39 AT1 receptor 4ZUD NTS1 receptor 4BUO
TM2 68 2.40x40 AT1 receptor 4ZUD δ receptor 4N6H
TM2 69 2.41x41 AT1 receptor 4ZUD CCR9 5LWE
TM2 70 2.42x42 AT1 receptor 4ZUD - -
TM2 71 2.43x43 AT1 receptor 4ZUD BLT1 receptor 5X33
TM2 72 2.44x44 AT1 receptor 4ZUD LPA1 receptor 4Z35
TM2 73 2.45x45 AT1 receptor 4ZUD - -
TM2 74 2.46x46 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM2 75 2.47x47 AT1 receptor 4ZUD LPA6 receptor 5XSZ
TM2 76 2.48x48 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM2 77 2.49x49 AT1 receptor 4ZUD CCR5 5UIW
TM2 78 2.50x50 AT1 receptor 4ZUD - -
TM2 79 2.51x51 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM2 80 2.52x52 AT1 receptor 4ZUD BLT1 receptor 5X33
TM2 81 2.53x53 AT1 receptor 4ZUD - -
TM2 82 2.54x54 AT1 receptor 4ZUD CXCR4 3ODU
TM2 83 2.55x55 D4 receptor 5WIV - -
TM2 84 2.56x551 D4 receptor 5WIV D4 receptor 5WIV
TM2 85 2.57x56 D4 receptor 5WIV - -
TM2 86 2.58x57 AT1 receptor 4ZUD - -
TM2 87 2.59x58 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM2 88 2.60x59 AT1 receptor 4ZUD - -
TM2 89 2.61x60 AT1 receptor 4ZUD 5-HT2C receptor 6BQH
TM2 90 2.62x61 AT1 receptor 4ZUD δ receptor 4N6H
TM2 91 2.63x62 AT1 receptor 4ZUD - -
ECL1 92 AT1 receptor 4ZUD - -
ECL1 93 AT1 receptor 4ZUD - -
ECL1 94 23.49x49 AT1 receptor 4ZUD - -
ECL1 95 23.50x50 AT1 receptor 4ZUD AT1 receptor 4ZUD
ECL1 96 23.51x51 AT1 receptor 4ZUD BLT1 receptor 5X33
ECL1 97 23.52x52 AT1 receptor 4ZUD - -
TM3 98 3.21x21 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM3 99 3.22x22 AT1 receptor 4ZUD C5a1 receptor 5O9H
TM3 100 3.23x23 AT1 receptor 4ZUD ETB receptor 5X93
TM3 101 3.24x24 AT1 receptor 4ZUD M2 receptor 3UON
TM3 102 3.25x25 AT1 receptor 4ZUD - -
TM3 103 3.26x26 AT1 receptor 4ZUD - -
TM3 104 3.27x27 AT1 receptor 4ZUD δ receptor 4N6H
TM3 105 3.28x28 AT1 receptor 4ZUD D4 receptor 5WIV
TM3 106 3.29x29 AT1 receptor 4ZUD LPA1 receptor 4Z35
TM3 107 3.30x30 AT1 receptor 4ZUD - -
TM3 108 3.31x31 AT1 receptor 4ZUD A1 receptor 5UEN
TM3 109 3.32x32 AT1 receptor 4ZUD LPA6 receptor 5XSZ
TM3 110 3.33x33 AT1 receptor 4ZUD - -
TM3 111 3.34x34 AT1 receptor 4ZUD CXCR4 3ODU
TM3 112 3.35x35 AT1 receptor 4ZUD BLT1 receptor 5X33
TM3 113 3.36x36 AT1 receptor 4ZUD H1 receptor 3RZE
TM3 114 3.37x37 AT1 receptor 4ZUD - -
TM3 115 3.38x38 AT1 receptor 4ZUD OX2 receptor 5WS3
TM3 116 3.39x39 AT1 receptor 4ZUD Rhodopsin 1GZM
TM3 117 3.40x40 AT1 receptor 4ZUD - -
TM3 118 3.41x41 AT1 receptor 4ZUD - -
TM3 119 3.42x42 AT1 receptor 4ZUD Y1 receptor 5ZBH
TM3 120 3.43x43 AT1 receptor 4ZUD - -
TM3 121 3.44x44 AT1 receptor 4ZUD CXCR4 3ODU
TM3 122 3.45x45 AT1 receptor 4ZUD CCR5 5UIW
TM3 123 3.46x46 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM3 124 3.47x47 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM3 125 3.48x48 AT1 receptor 4ZUD CXCR4 3ODU
TM3 126 3.49x49 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM3 127 3.50x50 AT1 receptor 4ZUD - -
TM3 128 3.51x51 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM3 129 3.52x52 AT1 receptor 4ZUD δ receptor 4N6H
TM3 130 3.53x53 AT1 receptor 4ZUD PAR2 5NDD
TM3 131 3.54x54 AT1 receptor 4ZUD - -
TM3 132 3.55x55 AT1 receptor 4ZUD CCR9 5LWE
TM3 133 3.56x56 AT1 receptor 4ZUD - -
ICL2 134 - - - -
ICL2 135 OX2 receptor 5WS3 - -
ICL2 136 OX2 receptor 5WS3 - -
ICL2 137 OX2 receptor 5WS3 - -
ICL2 138 OX2 receptor 5WS3 - -
ICL2 139 - - - -
TM4 140 4.38x38 AT1 receptor 4YAY LPA1 receptor 4Z35
TM4 141 4.39x39 AT1 receptor 4ZUD CCR5 5UIW
TM4 142 4.40x40 AT1 receptor 4ZUD - -
TM4 143 4.41x41 AT1 receptor 4ZUD μ receptor 4DKL
TM4 144 4.42x42 AT1 receptor 4ZUD ETB receptor 5X93
TM4 145 4.43x43 AT1 receptor 4ZUD BLT1 receptor 5X33
TM4 146 4.44x44 AT1 receptor 4ZUD - -
TM4 147 4.45x45 AT1 receptor 4ZUD CXCR4 3ODU
TM4 148 4.46x46 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM4 149 4.47x47 AT1 receptor 4ZUD D4 receptor 5WIV
TM4 150 4.48x48 AT1 receptor 4ZUD Rhodopsin 1GZM
TM4 151 4.49x49 AT1 receptor 4ZUD CXCR4 3ODU
TM4 152 4.50x50 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM4 153 4.51x51 AT1 receptor 4ZUD BLT1 receptor 5X33
TM4 154 4.52x52 AT1 receptor 4ZUD - -
TM4 155 4.53x53 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM4 156 4.54x54 AT1 receptor 4ZUD CXCR4 3ODU
TM4 157 4.55x55 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM4 158 4.56x56 AT1 receptor 4ZUD β2-adrenoceptor 5JQH
TM4 159 4.57x57 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM4 160 4.58x58 LPA6 receptor 5XSZ β2-adrenoceptor 5JQH
TM4 161 4.59x59 LPA6 receptor 5XSZ κ receptor 4DJH
TM4 162 4.60x60 AT1 receptor 4ZUD - -
TM4 163 4.61x61 AT1 receptor 4ZUD Rhodopsin 1GZM
TM4 164 4.62x62 AT1 receptor 4ZUD BLT1 receptor 5X33
TM4 165 4.63x63 AT1 receptor 4ZUD M3 receptor 4U15
TM4 166 4.64x64 AT1 receptor 4ZUD Y1 receptor 5ZBH
ECL2 167 - - - -
ECL2 168 - - - -
ECL2 169 - - - -
ECL2 170 - - - -
ECL2 171 - - - -
ECL2 172 - - - -
ECL2 173 - - - -
ECL2 174 - - - -
ECL2 175 - - - -
ECL2 176 - - - -
ECL2 177 - - - -
ECL2 178 - - - -
ECL2 179 - - - -
ECL2 180 - - - -
ECL2 181 - - - -
ECL2 182 - - - -
TM5 183 5.34x35 AT1 receptor 4ZUD Rhodopsin 1GZM
TM5 184 5.35x36 AT1 receptor 4ZUD ETB receptor 5X93
TM5 185 5.36x37 AT1 receptor 4ZUD Rhodopsin 1GZM
TM5 186 5.37x38 AT1 receptor 4ZUD C5a1 receptor 5O9H
TM5 187 5.38x39 AT1 receptor 4ZUD FFA1 receptor 5TZY
TM5 188 5.39x40 AT1 receptor 4ZUD ETB receptor 5X93
TM5 189 5.40x41 AT1 receptor 4ZUD PAR1 3VW7
TM5 190 5.41x42 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM5 191 5.42x43 AT1 receptor 4ZUD Y1 receptor 5ZBH
TM5 192 5.43x44 AT1 receptor 4ZUD CCR5 5UIW
TM5 193 5.44x45 AT1 receptor 4ZUD BLT1 receptor 5X33
TM5 194 5.45x46 AT1 receptor 4ZUD H1 receptor 3RZE
TM5 195 5.46x461 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM5 196 5.47x47 AT1 receptor 4ZUD OX2 receptor 5WS3
TM5 197 5.48x48 AT1 receptor 4ZUD δ receptor 4N6H
TM5 198 5.49x49 AT1 receptor 4ZUD δ receptor 4N6H
TM5 199 5.50x50 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM5 200 5.51x51 AT1 receptor 4ZUD PAR2 5NDD
TM5 201 5.52x52 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM5 202 5.53x53 AT1 receptor 4ZUD - -
TM5 203 5.54x54 AT1 receptor 4ZUD ETB receptor 5X93
TM5 204 5.55x55 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM5 205 5.56x56 AT1 receptor 4ZUD CB1 receptor 5TGZ
TM5 206 5.57x57 AT1 receptor 4ZUD OX2 receptor 5WS3
TM5 207 5.58x58 AT1 receptor 4ZUD - -
TM5 208 5.59x59 AT1 receptor 4ZUD PAR2 5NDD
TM5 209 5.60x60 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM5 210 5.61x61 AT1 receptor 4ZUD Rhodopsin 1GZM
TM5 211 5.62x62 AT1 receptor 4ZUD BLT1 receptor 5X33
TM5 212 5.63x63 AT1 receptor 4ZUD NOP receptor 5DHG
TM5 213 5.64x64 AT1 receptor 4ZUD 5-HT2C receptor 6BQH
TM5 214 5.65x65 AT1 receptor 4ZUD - -
TM5 215 5.66x66 δ receptor 4N6H δ receptor 4N6H
TM5 216 5.67x67 δ receptor 4N6H Rhodopsin 1GZM
TM5 217 5.68x68 δ receptor 4N6H - -
ICL3 218 - - - -
ICL3 219 - - - -
ICL3 220 - - - -
ICL3 221 - - - -
TM6 222 6.24x24 δ receptor 4N6H NOP receptor 5DHG
TM6 223 6.25x25 δ receptor 4N6H ETB receptor 5X93
TM6 224 6.26x26 δ receptor 4N6H Rhodopsin 1GZM
TM6 225 6.27x27 δ receptor 4N6H CXCR4 3ODU
TM6 226 6.28x28 δ receptor 4N6H NOP receptor 5DHG
TM6 227 6.29x29 δ receptor 4N6H - -
TM6 228 6.30x30 δ receptor 4N6H H1 receptor 3RZE
TM6 229 6.31x31 AT1 receptor 4ZUD - -
TM6 230 6.32x32 AT1 receptor 4ZUD LPA1 receptor 4Z35
TM6 231 6.33x33 AT1 receptor 4ZUD CXCR4 3ODU
TM6 232 6.34x34 AT1 receptor 4ZUD - -
TM6 233 6.35x35 AT1 receptor 4ZUD δ receptor 4N6H
TM6 234 6.36x36 AT1 receptor 4ZUD κ receptor 4DJH
TM6 235 6.37x37 AT1 receptor 4ZUD D4 receptor 5WIV
TM6 236 6.38x38 AT1 receptor 4ZUD CXCR4 3ODU
TM6 237 6.39x39 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM6 238 6.40x40 AT1 receptor 4ZUD PAR2 5NDD
TM6 239 6.41x41 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM6 240 6.42x42 AT1 receptor 4ZUD - -
TM6 241 6.43x43 AT1 receptor 4ZUD apelin receptor 5VBL
TM6 242 6.44x44 AT1 receptor 4ZUD - -
TM6 243 6.45x45 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM6 244 6.46x46 AT1 receptor 4ZUD NOP receptor 5DHG
TM6 245 6.47x47 AT1 receptor 4ZUD - -
TM6 246 6.48x48 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM6 247 6.49x49 AT1 receptor 4ZUD κ receptor 4DJH
TM6 248 6.50x50 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM6 249 6.51x51 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM6 250 6.52x52 AT1 receptor 4ZUD CXCR4 3ODU
TM6 251 6.53x53 AT1 receptor 4ZUD apelin receptor 5VBL
TM6 252 6.54x54 AT1 receptor 4ZUD CCR9 5LWE
TM6 253 6.55x55 AT1 receptor 4ZUD CCR9 5LWE
TM6 254 6.56x56 AT1 receptor 4ZUD κ receptor 4DJH
TM6 255 6.57x57 AT1 receptor 4ZUD - -
TM6 256 6.58x58 AT1 receptor 4ZUD β2-adrenoceptor 5JQH
TM6 257 6.59x59 AT1 receptor 4ZUD δ receptor 4N6H
TM6 258 6.60x60 AT1 receptor 4ZUD OX2 receptor 5WS3
TM6 259 6.61x61 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM6 260 6.62x62 AT1 receptor 4ZUD PAR2 5NDD
TM6 261 6.63x63 AT1 receptor 4ZUD - -
TM6 262 6.64x64 AT1 receptor 4ZUD - -
ECL3 263 - - - -
ECL3 264 CXCR4 3ODU - -
ECL3 265 CXCR4 3ODU - -
ECL3 266 - - - -
TM7 267 7.24x23 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM7 268 7.25x24 AT1 receptor 4ZUD - -
TM7 269 7.26x25 AT1 receptor 4ZUD - -
TM7 270 7.27x26 AT1 receptor 4ZUD - -
TM7 271 7.28x27 AT1 receptor 4ZUD ETB receptor 5X93
TM7 272 7.29x28 AT1 receptor 4ZUD - -
TM7 273 7.30x29 AT1 receptor 4ZUD δ receptor 4N6H
TM7 274 7.31x30 AT1 receptor 4ZUD BLT1 receptor 5X33
TM7 275 7.32x31 AT1 receptor 4ZUD CXCR4 3ODU
TM7 276 7.33x32 AT1 receptor 4ZUD S1P1 receptor 3V2Y
TM7 277 7.34x33 AT1 receptor 4ZUD β2-adrenoceptor 5JQH
TM7 278 7.35x34 AT1 receptor 4ZUD P2Y12 receptor 4NTJ
TM7 279 7.36x35 AT1 receptor 4ZUD 5-HT1B receptor 4IAQ
TM7 280 7.37x36 AT1 receptor 4ZUD κ receptor 4DJH
TM7 281 7.38x37 AT1 receptor 4ZUD OX2 receptor 5WS3
TM7 282 7.39x38 AT1 receptor 4ZUD FFA1 receptor 5KW2
TM7 283 7.40x39 AT1 receptor 4ZUD LPA1 receptor 4Z35
TM7 284 7.41x40 AT1 receptor 4ZUD δ receptor 4N6H
TM7 285 7.42x41 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM7 286 7.43x42 AT1 receptor 4ZUD CXCR4 3ODU
TM7 287 7.44x43 AT1 receptor 4ZUD LPA6 receptor 5XSZ
TM7 288 7.45x45 AT1 receptor 4ZUD BLT1 receptor 5X33
TM7 289 7.46x46 AT1 receptor 4ZUD δ receptor 4N6H
TM7 290 7.47x47 AT1 receptor 4ZUD - -
TM7 291 7.48x48 AT1 receptor 4ZUD Y1 receptor 5ZBH
TM7 292 7.49x49 AT1 receptor 4ZUD - -
TM7 293 7.50x50 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM7 294 7.51x51 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM7 295 7.52x52 AT1 receptor 4ZUD δ receptor 4N6H
TM7 296 7.53x53 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM7 297 7.54x54 AT1 receptor 4ZUD - -
TM7 298 7.55x55 AT1 receptor 4ZUD - -
TM7 299 7.56x56 LPA6 receptor 5XSZ Rhodopsin 1GZM
H8 300 8.47x47 δ receptor 4N6H D4 receptor 5WIV
H8 301 8.48x48 δ receptor 4N6H A1 receptor 5UEN
H8 302 8.49x49 δ receptor 4N6H P2Y12 receptor 4NTJ
H8 303 8.50x50 δ receptor 4N6H δ receptor 4N6H
H8 304 8.51x51 δ receptor 4N6H - -
H8 305 8.52x52 δ receptor 4N6H - -
H8 306 8.53x53 δ receptor 4N6H AT2 receptor 5UNG
H8 307 8.54x54 δ receptor 4N6H CCR9 5LWE
H8 308 8.55x55 δ receptor 4N6H Y1 receptor 5ZBH
H8 309 8.56x56 δ receptor 4N6H 5-HT2B receptor 4IB4
H8 310 8.57x57 δ receptor 4N6H δ receptor 4N6H
H8 311 8.58x58 δ receptor 4N6H - -
H8 312 8.59x59 δ receptor 4N6H CCR9 5LWE
H8 313 8.60x60 δ receptor 4N6H - -
H8 314 8.61x61 CCR9 5LWE CCR9 5LWE
C-term 315 - - - -
C-term 316 - - - -
C-term 317 - - - -
C-term 318 - - - -
C-term 319 - - - -