GPR146 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate (Δ distance (Å): 7.06 docs)

VERSION

2018-07-10

MAIN TEMPLATE

PAR2 (sequence similarity: 32%) PDB: 5NDD

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 74.3 11.3 14.3
Side-chains 15.7 49.7 34.7

Number of backbone templates: 8
Number of rotamer templates: 38

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5NDD
5WIV
4ZUD
5WS3
5XSZ
4N6H
3ODU
5LWE
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 20 PAR2 5NDD PAR2 5NDD
N-term 21 PAR2 5NDD PAR2 5NDD
N-term 22 PAR2 5NDD PAR2 5NDD
N-term 23 PAR2 5NDD PAR2 5NDD
N-term 24 PAR2 5NDD PAR2 5NDD
TM1 25 1.30x30 PAR2 5NDD NOP receptor 5DHG
TM1 26 1.31x31 PAR2 5NDD PAR1 3VW7
TM1 27 1.32x32 PAR2 5NDD A2A receptor 5WF5
TM1 28 1.33x33 PAR2 5NDD PAR1 3VW7
TM1 29 1.34x34 PAR2 5NDD P2Y12 receptor 4NTJ
TM1 30 1.35x35 PAR2 5NDD FFA1 receptor 5TZY
TM1 31 1.36x36 PAR2 5NDD D4 receptor 5WIV
TM1 32 1.37x37 PAR2 5NDD P2Y12 receptor 4NTJ
TM1 33 1.38x38 PAR2 5NDD D4 receptor 5WIV
TM1 34 1.39x39 PAR2 5NDD 5-HT2B receptor 4IB4
TM1 35 1.40x40 PAR2 5NDD FFA1 receptor 5TZY
TM1 36 1.41x41 PAR2 5NDD P2Y12 receptor 4NTJ
TM1 37 1.42x42 PAR2 5NDD - -
TM1 38 1.43x43 PAR2 5NDD β2-adrenoceptor 3SN6
TM1 39 1.44x44 PAR2 5NDD - -
TM1 40 1.45x45 PAR2 5NDD PAR2 5NDD
TM1 41 1.46x46 PAR2 5NDD P2Y12 receptor 4NTJ
TM1 42 1.47x47 PAR2 5NDD PAR2 5NDD
TM1 43 1.48x48 PAR2 5NDD - -
TM1 44 1.49x49 PAR2 5NDD - -
TM1 45 1.50x50 PAR2 5NDD PAR2 5NDD
TM1 46 1.51x51 PAR2 5NDD 5-HT1B receptor 4IAQ
TM1 47 1.52x52 PAR2 5NDD P2Y12 receptor 4NTJ
TM1 48 1.53x53 PAR2 5NDD Y1 receptor 5ZBH
TM1 49 1.54x54 PAR2 5NDD AT1 receptor 4ZUD
TM1 50 1.55x55 PAR2 5NDD 5-HT2B receptor 4IB4
TM1 51 1.56x56 PAR2 5NDD A2A receptor 4UHR
TM1 52 1.57x57 PAR2 5NDD - -
TM1 53 1.58x58 PAR2 5NDD PAR2 5NDD
TM1 54 1.59x59 PAR2 5NDD CB1 receptor 5XRA
TM1 55 1.60x60 PAR2 5NDD CB1 receptor 5XRA
ICL1 56 - - - -
ICL1 57 - - - -
ICL1 58 - - - -
ICL1 59 - - - -
ICL1 60 - - - -
ICL1 61 - - - -
ICL1 62 - - - -
ICL1 63 - - - -
ICL1 64 - - - -
TM2 65 2.37x37 PAR2 5NDD 5-HT2B receptor 4IB4
TM2 66 2.38x38 PAR2 5NDD - -
TM2 67 2.39x39 PAR2 5NDD NTS1 receptor 4XES
TM2 68 2.40x40 PAR2 5NDD A2A receptor 4UHR
TM2 69 2.41x41 PAR2 5NDD CCR9 5LWE
TM2 70 2.42x42 PAR2 5NDD - -
TM2 71 2.43x43 PAR2 5NDD A2A receptor 4UHR
TM2 72 2.44x44 PAR2 5NDD PAR2 5NDD
TM2 73 2.45x45 PAR2 5NDD - -
TM2 74 2.46x46 PAR2 5NDD PAR2 5NDD
TM2 75 2.47x47 PAR2 5NDD P2Y12 receptor 4NTJ
TM2 76 2.48x48 PAR2 5NDD PAR2 5NDD
TM2 77 2.49x49 PAR2 5NDD P2Y12 receptor 4NTJ
TM2 78 2.50x50 PAR2 5NDD - -
TM2 79 2.51x51 PAR2 5NDD PAR2 5NDD
TM2 80 2.52x52 PAR2 5NDD A2A receptor 5WF5
TM2 81 2.53x53 PAR2 5NDD - -
TM2 82 2.54x54 PAR2 5NDD PAR2 5NDD
TM2 83 2.55x55 D4 receptor 5WIV - -
TM2 84 2.56x551 D4 receptor 5WIV D4 receptor 5WIV
TM2 85 2.57x56 D4 receptor 5WIV - -
TM2 86 2.58x57 PAR2 5NDD - -
TM2 87 2.59x58 PAR2 5NDD PAR2 5NDD
TM2 88 2.60x59 PAR2 5NDD - -
TM2 89 2.61x60 PAR2 5NDD 5-HT1B receptor 4IAQ
TM2 90 2.62x61 PAR2 5NDD δ receptor 4N6H
TM2 91 2.63x62 PAR2 5NDD - -
ECL1 92 - - - -
ECL1 93 AT1 receptor 4ZUD - -
ECL1 94 23.49x49 AT1 receptor 4ZUD - -
ECL1 95 23.50x50 AT1 receptor 4ZUD AT1 receptor 4ZUD
ECL1 96 23.51x51 AT1 receptor 4ZUD BLT1 receptor 5X33
ECL1 97 23.52x52 - - - -
TM3 98 3.21x21 PAR2 5NDD PAR2 5NDD
TM3 99 3.22x22 PAR2 5NDD C5a1 receptor 5O9H
TM3 100 3.23x23 PAR2 5NDD PAR1 3VW7
TM3 101 3.24x24 PAR2 5NDD P2Y12 receptor 4NTJ
TM3 102 3.25x25 PAR2 5NDD - -
TM3 103 3.26x26 PAR2 5NDD - -
TM3 104 3.27x27 PAR2 5NDD 5-HT2B receptor 4IB4
TM3 105 3.28x28 PAR2 5NDD PAR2 5NDD
TM3 106 3.29x29 PAR2 5NDD LPA1 receptor 4Z35
TM3 107 3.30x30 PAR2 5NDD - -
TM3 108 3.31x31 PAR2 5NDD A1 receptor 5UEN
TM3 109 3.32x32 PAR2 5NDD PAR2 5NDD
TM3 110 3.33x33 PAR2 5NDD - -
TM3 111 3.34x34 PAR2 5NDD A2A receptor 4UHR
TM3 112 3.35x35 PAR2 5NDD BLT1 receptor 5X33
TM3 113 3.36x36 PAR2 5NDD 5-HT2B receptor 4IB4
TM3 114 3.37x37 PAR2 5NDD - -
TM3 115 3.38x38 PAR2 5NDD OX2 receptor 5WS3
TM3 116 3.39x39 PAR2 5NDD A2A receptor 5WF6
TM3 117 3.40x40 PAR2 5NDD - -
TM3 118 3.41x41 PAR2 5NDD - -
TM3 119 3.42x42 PAR2 5NDD A2A receptor 4UHR
TM3 120 3.43x43 PAR2 5NDD - -
TM3 121 3.44x44 PAR2 5NDD NTS1 receptor 4XES
TM3 122 3.45x45 PAR2 5NDD P2Y12 receptor 4NTJ
TM3 123 3.46x46 PAR2 5NDD PAR2 5NDD
TM3 124 3.47x47 PAR2 5NDD PAR2 5NDD
TM3 125 3.48x48 PAR2 5NDD 5-HT1B receptor 4IAQ
TM3 126 3.49x49 PAR2 5NDD P2Y12 receptor 4NTJ
TM3 127 3.50x50 PAR2 5NDD - -
TM3 128 3.51x51 PAR2 5NDD P2Y12 receptor 4NTJ
TM3 129 3.52x52 PAR2 5NDD μ receptor 6DDE
TM3 130 3.53x53 PAR2 5NDD PAR2 5NDD
TM3 131 3.54x54 PAR2 5NDD - -
TM3 132 3.55x55 PAR2 5NDD FFA1 receptor 5TZY
TM3 133 3.56x56 PAR2 5NDD - -
ICL2 134 - - - -
ICL2 135 OX2 receptor 5WS3 - -
ICL2 136 OX2 receptor 5WS3 - -
ICL2 137 OX2 receptor 5WS3 - -
ICL2 138 OX2 receptor 5WS3 - -
ICL2 139 - - - -
TM4 140 4.38x38 PAR2 5NDD 5-HT2B receptor 4IB4
TM4 141 4.39x39 PAR2 5NDD CCR5 5UIW
TM4 142 4.40x40 PAR2 5NDD - -
TM4 143 4.41x41 PAR2 5NDD μ receptor 6DDE
TM4 144 4.42x42 PAR2 5NDD NTS1 receptor 4XES
TM4 145 4.43x43 PAR2 5NDD BLT1 receptor 5X33
TM4 146 4.44x44 PAR2 5NDD - -
TM4 147 4.45x45 PAR2 5NDD μ receptor 6DDE
TM4 148 4.46x46 PAR2 5NDD PAR1 3VW7
TM4 149 4.47x47 PAR2 5NDD D4 receptor 5WIV
TM4 150 4.48x48 PAR2 5NDD US28 4XT1
TM4 151 4.49x49 PAR2 5NDD 5-HT2B receptor 4IB4
TM4 152 4.50x50 PAR2 5NDD PAR2 5NDD
TM4 153 4.51x51 PAR2 5NDD BLT1 receptor 5X33
TM4 154 4.52x52 PAR2 5NDD - -
TM4 155 4.53x53 PAR2 5NDD PAR1 3VW7
TM4 156 4.54x54 PAR2 5NDD PAR2 5NDD
TM4 157 4.55x55 PAR2 5NDD PAR2 5NDD
TM4 158 4.56x56 PAR2 5NDD β2-adrenoceptor 3SN6
TM4 159 4.57x57 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM4 160 4.58x58 LPA6 receptor 5XSZ β2-adrenoceptor 3SN6
TM4 161 4.59x59 LPA6 receptor 5XSZ κ receptor 4DJH
TM4 162 4.60x60 PAR2 5NDD - -
TM4 163 4.61x61 PAR2 5NDD PAR2 5NDD
TM4 164 4.62x62 PAR2 5NDD PAR1 3VW7
TM4 165 4.63x63 PAR2 5NDD NTS1 receptor 4XES
TM4 166 4.64x64 AT1 receptor 4ZUD Y1 receptor 5ZBH
ECL2 167 - - - -
ECL2 168 - - - -
ECL2 169 - - - -
ECL2 170 - - - -
ECL2 171 - - - -
ECL2 172 - - - -
ECL2 173 - - - -
ECL2 174 - - - -
ECL2 175 - - - -
ECL2 176 - - - -
ECL2 177 - - - -
ECL2 178 - - - -
ECL2 179 - - - -
ECL2 180 - - - -
ECL2 181 - - - -
ECL2 182 - - - -
TM5 183 5.34x35 PAR2 5NDD Rhodopsin 5DYS
TM5 184 5.35x36 PAR2 5NDD PAR1 3VW7
TM5 185 5.36x37 PAR2 5NDD P2Y12 receptor 4NTJ
TM5 186 5.37x38 PAR2 5NDD C5a1 receptor 5O9H
TM5 187 5.38x39 PAR2 5NDD FFA1 receptor 5TZY
TM5 188 5.39x40 PAR2 5NDD ETB receptor 5X93
TM5 189 5.40x41 PAR2 5NDD PAR1 3VW7
TM5 190 5.41x42 PAR2 5NDD AT1 receptor 4ZUD
TM5 191 5.42x43 PAR2 5NDD PAR2 5NDD
TM5 192 5.43x44 PAR2 5NDD PAF receptor 5ZKQ
TM5 193 5.44x45 PAR2 5NDD A2A receptor 4UHR
TM5 194 5.45x46 PAR2 5NDD P2Y12 receptor 4NTJ
TM5 195 5.46x461 PAR2 5NDD AT1 receptor 4ZUD
TM5 196 5.47x47 PAR2 5NDD OX2 receptor 5WS3
TM5 197 5.48x48 PAR2 5NDD δ receptor 4N6H
TM5 198 5.49x49 PAR2 5NDD PAR1 3VW7
TM5 199 5.50x50 PAR2 5NDD PAR2 5NDD
TM5 200 5.51x51 PAR2 5NDD PAR2 5NDD
TM5 201 5.52x52 PAR2 5NDD P2Y12 receptor 4NTJ
TM5 202 5.53x53 PAR2 5NDD - -
TM5 203 5.54x54 PAR2 5NDD PAR2 5NDD
TM5 204 5.55x55 PAR2 5NDD A2A receptor 4UHR
TM5 205 5.56x56 PAR2 5NDD US28 4XT1
TM5 206 5.57x57 PAR2 5NDD PAR2 5NDD
TM5 207 5.58x58 PAR2 5NDD - -
TM5 208 5.59x59 PAR2 5NDD PAR2 5NDD
TM5 209 5.60x60 PAR2 5NDD PAR2 5NDD
TM5 210 5.61x61 PAR2 5NDD Rhodopsin 5DYS
TM5 211 5.62x62 PAR2 5NDD BLT1 receptor 5X33
TM5 212 5.63x63 PAR2 5NDD PAR2 5NDD
TM5 213 5.64x64 PAR2 5NDD 5-HT2C receptor 6BQH
TM5 214 5.65x65 PAR2 5NDD - -
TM5 215 5.66x66 - - - -
TM5 216 5.67x67 - - - -
TM5 217 5.68x68 - - - -
ICL3 218 - - - -
ICL3 219 - - - -
ICL3 220 - - - -
ICL3 221 - - - -
TM6 222 6.24x24 δ receptor 4N6H A2A receptor 4UHR
TM6 223 6.25x25 δ receptor 4N6H ETB receptor 5X93
TM6 224 6.26x26 δ receptor 4N6H A2A receptor 4UHR
TM6 225 6.27x27 PAR2 5NDD CXCR4 3ODU
TM6 226 6.28x28 PAR2 5NDD μ receptor 6DDE
TM6 227 6.29x29 PAR2 5NDD - -
TM6 228 6.30x30 PAR2 5NDD A2A receptor 4UHR
TM6 229 6.31x31 PAR2 5NDD - -
TM6 230 6.32x32 PAR2 5NDD PAR1 3VW7
TM6 231 6.33x33 PAR2 5NDD A2A receptor 4UHR
TM6 232 6.34x34 PAR2 5NDD - -
TM6 233 6.35x35 PAR2 5NDD μ receptor 6DDE
TM6 234 6.36x36 PAR2 5NDD κ receptor 4DJH
TM6 235 6.37x37 PAR2 5NDD PAR2 5NDD
TM6 236 6.38x38 PAR2 5NDD P2Y12 receptor 4PXZ
TM6 237 6.39x39 PAR2 5NDD PAR1 3VW7
TM6 238 6.40x40 PAR2 5NDD PAR2 5NDD
TM6 239 6.41x41 PAR2 5NDD PAR2 5NDD
TM6 240 6.42x42 PAR2 5NDD - -
TM6 241 6.43x43 PAR2 5NDD P2Y1 receptor 4XNW
TM6 242 6.44x44 PAR2 5NDD - -
TM6 243 6.45x45 PAR2 5NDD P2Y12 receptor 4NTJ
TM6 244 6.46x46 AT1 receptor 4ZUD NOP receptor 5DHG
TM6 245 6.47x47 AT1 receptor 4ZUD - -
TM6 246 6.48x48 PAR2 5NDD μ receptor 6DDE
TM6 247 6.49x49 PAR2 5NDD PAR2 5NDD
TM6 248 6.50x50 PAR2 5NDD PAR2 5NDD
TM6 249 6.51x51 PAR2 5NDD PAF receptor 5ZKQ
TM6 250 6.52x52 PAR2 5NDD CXCR4 3ODU
TM6 251 6.53x53 PAR2 5NDD PAR2 5NDD
TM6 252 6.54x54 PAR2 5NDD A2A receptor 4UHR
TM6 253 6.55x55 PAR2 5NDD PAR2 5NDD
TM6 254 6.56x56 PAR2 5NDD PAF receptor 5ZKQ
TM6 255 6.57x57 PAR2 5NDD - -
TM6 256 6.58x58 PAR2 5NDD PAR2 5NDD
TM6 257 6.59x59 PAR2 5NDD P2Y12 receptor 4NTJ
TM6 258 6.60x60 PAR2 5NDD OX2 receptor 5WS3
TM6 259 6.61x61 PAR2 5NDD NTS1 receptor 4GRV
TM6 260 6.62x62 PAR2 5NDD PAR2 5NDD
TM6 261 6.63x63 AT1 receptor 4ZUD - -
TM6 262 6.64x64 AT1 receptor 4ZUD - -
ECL3 263 - - - -
ECL3 264 CXCR4 3ODU - -
ECL3 265 CXCR4 3ODU - -
ECL3 266 - - - -
TM7 267 7.24x23 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM7 268 7.25x24 AT1 receptor 4ZUD - -
TM7 269 7.26x25 AT1 receptor 4ZUD - -
TM7 270 7.27x26 AT1 receptor 4ZUD - -
TM7 271 7.28x27 AT1 receptor 4ZUD ETB receptor 5X93
TM7 272 7.29x28 AT1 receptor 4ZUD - -
TM7 273 7.30x29 AT1 receptor 4ZUD δ receptor 4N6H
TM7 274 7.31x30 PAR2 5NDD P2Y12 receptor 4NTJ
TM7 275 7.32x31 PAR2 5NDD NTS1 receptor 4XES
TM7 276 7.33x32 PAR2 5NDD PAR1 3VW7
TM7 277 7.34x33 PAR2 5NDD P2Y12 receptor 4NTJ
TM7 278 7.35x34 PAR2 5NDD P2Y12 receptor 4NTJ
TM7 279 7.36x35 PAR2 5NDD 5-HT1B receptor 4IAQ
TM7 280 7.37x36 PAR2 5NDD μ receptor 6DDE
TM7 281 7.38x37 PAR2 5NDD OX2 receptor 5WS3
TM7 282 7.39x38 PAR2 5NDD FFA1 receptor 5KW2
TM7 283 7.40x39 PAR2 5NDD AT2 receptor 5UNG
TM7 284 7.41x40 PAR2 5NDD PAR2 5NDD
TM7 285 7.42x41 PAR2 5NDD P2Y1 receptor 4XNW
TM7 286 7.43x42 PAR2 5NDD CXCR4 3ODU
TM7 287 7.44x43 PAR2 5NDD LPA6 receptor 5XSZ
TM7 288 7.45x45 PAR2 5NDD PAR1 3VW7
TM7 289 7.46x46 PAR2 5NDD PAR2 5NDD
TM7 290 7.47x47 PAR2 5NDD - -
TM7 291 7.48x48 PAR2 5NDD A2A receptor 4UHR
TM7 292 7.49x49 PAR2 5NDD - -
TM7 293 7.50x50 PAR2 5NDD PAR2 5NDD
TM7 294 7.51x51 PAR2 5NDD PAR1 3VW7
TM7 295 7.52x52 PAR2 5NDD μ receptor 6DDE
TM7 296 7.53x53 PAR2 5NDD PAR2 5NDD
TM7 297 7.54x54 PAR2 5NDD - -
TM7 298 7.55x55 PAR2 5NDD A2A receptor 4UHR
TM7 299 7.56x56 PAR2 5NDD Rhodopsin 5DYS
H8 300 8.47x47 PAR2 5NDD 5-HT2B receptor 4IB4
H8 301 8.48x48 PAR2 5NDD A1 receptor 5UEN
H8 302 8.49x49 PAR2 5NDD P2Y12 receptor 4NTJ
H8 303 8.50x50 PAR2 5NDD PAR2 5NDD
H8 304 8.51x51 PAR2 5NDD - -
H8 305 8.52x52 PAR2 5NDD - -
H8 306 8.53x53 PAR2 5NDD AT2 receptor 5UNG
H8 307 8.54x54 PAR2 5NDD AT2 receptor 5UNG
H8 308 8.55x55 PAR2 5NDD Y1 receptor 5ZBH
H8 309 8.56x56 PAR2 5NDD 5-HT2B receptor 4IB4
H8 310 8.57x57 PAR2 5NDD 5-HT1B receptor 4IAQ
H8 311 8.58x58 PAR2 5NDD - -
H8 312 8.59x59 CCR9 5LWE CCR9 5LWE
H8 313 8.60x60 CCR9 5LWE - -
H8 314 8.61x61 CCR9 5LWE CCR9 5LWE
C-term 315 - - - -
C-term 316 - - - -
C-term 317 - - - -
C-term 318 - - - -
C-term 319 - - - -