GPR18 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate (Δ distance (Å): 7.24 docs)

VERSION

2018-07-10

MAIN TEMPLATE

μ receptor (sequence similarity: 43%) PDB: 6DDE

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 77.1 15.1 7.9
Side-chains 17.8 54.8 27.4

Number of backbone templates: 8
Number of rotamer templates: 43

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6DDE
5XSZ
5UNG
4NTJ
3VW7
5DYS
4DJH
5VBL
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 18 - - - -
N-term 19 - - - -
N-term 20 - - - -
N-term 21 μ receptor 6DDE μ receptor 6DDE
N-term 22 μ receptor 6DDE μ receptor 6DDE
TM1 23 1.33x33 μ receptor 6DDE μ receptor 5C1M
TM1 24 1.34x34 μ receptor 6DDE AT2 receptor 5UNG
TM1 25 1.35x35 μ receptor 6DDE C5a1 receptor 5O9H
TM1 26 1.36x36 μ receptor 6DDE C5a1 receptor 5O9H
TM1 27 1.37x37 μ receptor 6DDE C5a1 receptor 5O9H
TM1 28 1.38x38 μ receptor 6DDE - -
TM1 29 1.39x39 μ receptor 6DDE μ receptor 6DDE
TM1 30 1.40x40 μ receptor 6DDE μ receptor 6DDE
TM1 31 1.41x41 μ receptor 6DDE - -
TM1 32 1.42x42 μ receptor 6DDE PAF receptor 5ZKQ
TM1 33 1.43x43 μ receptor 6DDE PAR1 3VW7
TM1 34 1.44x44 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 35 1.45x45 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 36 1.46x46 μ receptor 6DDE μ receptor 6DDE
TM1 37 1.47x47 μ receptor 6DDE PAR1 3VW7
TM1 38 1.48x48 μ receptor 6DDE μ receptor 6DDE
TM1 39 1.49x49 μ receptor 6DDE AT2 receptor 5UNG
TM1 40 1.50x50 μ receptor 6DDE μ receptor 6DDE
TM1 41 1.51x51 μ receptor 6DDE PAR1 3VW7
TM1 42 1.52x52 μ receptor 6DDE ETB receptor 5X93
TM1 43 1.53x53 μ receptor 6DDE PAR1 3VW7
TM1 44 1.54x54 μ receptor 6DDE PAR2 5NDD
TM1 45 1.55x55 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 46 1.56x56 μ receptor 6DDE μ receptor 6DDE
TM1 47 1.57x57 μ receptor 6DDE PAR1 3VW7
TM1 48 1.58x58 μ receptor 6DDE 5-HT2B receptor 4IB4
TM1 49 1.59x59 μ receptor 6DDE LPA6 receptor 5XSZ
TM1 50 1.60x60 μ receptor 6DDE - -
ICL1 51 - - - -
ICL1 52 LPA6 receptor 5XSZ - -
ICL1 53 LPA6 receptor 5XSZ - -
ICL1 54 - - - -
TM2 55 2.37x37 LPA6 receptor 5XSZ 5-HT1B receptor 4IAQ
TM2 56 2.38x38 μ receptor 6DDE NTS1 receptor 4XES
TM2 57 2.39x39 μ receptor 6DDE NTS1 receptor 4XES
TM2 58 2.40x40 μ receptor 6DDE LPA6 receptor 5XSZ
TM2 59 2.41x41 μ receptor 6DDE μ receptor 6DDE
TM2 60 2.42x42 μ receptor 6DDE μ receptor 6DDE
TM2 61 2.43x43 μ receptor 6DDE PAR1 3VW7
TM2 62 2.44x44 μ receptor 6DDE 5-HT2B receptor 4IB4
TM2 63 2.45x45 μ receptor 6DDE μ receptor 6DDE
TM2 64 2.46x46 μ receptor 6DDE - -
TM2 65 2.47x47 μ receptor 6DDE μ receptor 6DDE
TM2 66 2.48x48 μ receptor 6DDE μ receptor 6DDE
TM2 67 2.49x49 μ receptor 6DDE - -
TM2 68 2.50x50 μ receptor 6DDE μ receptor 6DDE
TM2 69 2.51x51 μ receptor 6DDE PAR2 5NDD
TM2 70 2.52x52 μ receptor 6DDE H1 receptor 3RZE
TM2 71 2.53x53 μ receptor 6DDE PAR1 3VW7
TM2 72 2.54x54 μ receptor 6DDE P2Y12 receptor 4NTJ
TM2 73 2.55x55 μ receptor 6DDE - -
TM2 74 2.56x56 μ receptor 6DDE μ receptor 6DDE
TM2 75 2.57x57 μ receptor 6DDE μ receptor 6DDE
TM2 76 2.58x58 μ receptor 6DDE μ receptor 6DDE
TM2 77 2.59x59 μ receptor 6DDE μ receptor 6DDE
TM2 78 2.60x60 μ receptor 6DDE LPA6 receptor 5XSZ
TM2 79 2.61x61 μ receptor 6DDE US28 4XT1
TM2 80 2.62x62 μ receptor 6DDE P2Y1 receptor 4XNW
TM2 81 2.63x63 μ receptor 6DDE PAR1 3VW7
TM2 82 2.64x64 μ receptor 6DDE μ receptor 6DDE
TM2 83 2.65x65 μ receptor 6DDE P2Y12 receptor 4NTJ
TM2 84 2.66x66 μ receptor 6DDE M4 receptor 5DSG
ECL1 85 - - - -
ECL1 86 23.49x49 LPA6 receptor 5XSZ CCR2 5T1A
ECL1 87 23.50x50 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
ECL1 88 23.51x51 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
ECL1 89 23.52x52 - - - -
TM3 90 3.21x21 μ receptor 6DDE μ receptor 6DDE
TM3 91 3.22x22 μ receptor 6DDE PAR2 5NDD
TM3 92 3.23x23 μ receptor 6DDE AT1 receptor 4ZUD
TM3 93 3.24x24 μ receptor 6DDE apelin receptor 5VBL
TM3 94 3.25x25 μ receptor 6DDE μ receptor 6DDE
TM3 95 3.26x26 μ receptor 6DDE P2Y12 receptor 4NTJ
TM3 96 3.27x27 μ receptor 6DDE μ receptor 6DDE
TM3 97 3.28x28 μ receptor 6DDE PAR2 5NDD
TM3 98 3.29x29 μ receptor 6DDE PAF receptor 5ZKQ
TM3 99 3.30x30 μ receptor 6DDE PAR1 3VW7
TM3 100 3.31x31 μ receptor 6DDE PAF receptor 5ZKQ
TM3 101 3.32x32 μ receptor 6DDE - -
TM3 102 3.33x33 μ receptor 6DDE 5-HT2B receptor 4IB4
TM3 103 3.34x34 μ receptor 6DDE P2Y12 receptor 4NTJ
TM3 104 3.35x35 μ receptor 6DDE - -
TM3 105 3.36x36 μ receptor 6DDE - -
TM3 106 3.37x37 μ receptor 6DDE OX2 receptor 5WS3
TM3 107 3.38x38 μ receptor 6DDE P2Y12 receptor 4NTJ
TM3 108 3.39x39 μ receptor 6DDE A2A receptor 5WF6
TM3 109 3.40x40 μ receptor 6DDE Rhodopsin 5DYS
TM3 110 3.41x41 μ receptor 6DDE 5-HT2B receptor 4IB4
TM3 111 3.42x42 μ receptor 6DDE PAR1 3VW7
TM3 112 3.43x43 μ receptor 6DDE μ receptor 6DDE
TM3 113 3.44x44 μ receptor 6DDE NTS1 receptor 4XES
TM3 114 3.45x45 μ receptor 6DDE CXCR4 3ODU
TM3 115 3.46x46 μ receptor 6DDE PAR1 3VW7
TM3 116 3.47x47 μ receptor 6DDE μ receptor 6DDE
TM3 117 3.48x48 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 118 3.49x49 μ receptor 6DDE μ receptor 6DDE
TM3 119 3.50x50 μ receptor 6DDE μ receptor 6DDE
TM3 120 3.51x51 μ receptor 6DDE μ receptor 6DDE
TM3 121 3.52x52 μ receptor 6DDE - -
TM3 122 3.53x53 μ receptor 6DDE μ receptor 6DDE
TM3 123 3.54x54 μ receptor 6DDE PAR2 5NDD
TM3 124 3.55x55 μ receptor 6DDE PAR1 3VW7
TM3 125 3.56x56 μ receptor 6DDE CCR9 5LWE
ICL2 126 34.50x50 - - - -
ICL2 127 34.51x51 LPA6 receptor 5XSZ - -
ICL2 128 34.52x52 LPA6 receptor 5XSZ - -
ICL2 129 34.53x53 LPA6 receptor 5XSZ μ receptor 6DDE
ICL2 130 34.54x54 LPA6 receptor 5XSZ NTS1 receptor 4XES
ICL2 131 34.55x55 LPA6 receptor 5XSZ - -
ICL2 132 34.56x56 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
ICL2 133 34.57x57 - - - -
TM4 134 4.38x38 μ receptor 6DDE Y1 receptor 5ZBH
TM4 135 4.39x39 μ receptor 6DDE M3 receptor 4U15
TM4 136 4.40x40 μ receptor 6DDE FFA1 receptor 5TZY
TM4 137 4.41x41 μ receptor 6DDE κ receptor 4DJH
TM4 138 4.42x42 μ receptor 6DDE μ receptor 6DDE
TM4 139 4.43x43 μ receptor 6DDE CCR5 5UIW
TM4 140 4.44x44 μ receptor 6DDE δ receptor 4N6H
TM4 141 4.45x45 μ receptor 6DDE apelin receptor 5VBL
TM4 142 4.46x46 μ receptor 6DDE PAR1 3VW7
TM4 143 4.47x47 μ receptor 6DDE μ receptor 6DDE
TM4 144 4.48x48 μ receptor 6DDE CXCR4 3ODU
TM4 145 4.49x49 μ receptor 6DDE P2Y1 receptor 4XNW
TM4 146 4.50x50 μ receptor 6DDE μ receptor 6DDE
TM4 147 4.51x51 μ receptor 6DDE μ receptor 6DDE
TM4 148 4.52x52 μ receptor 6DDE AT2 receptor 5UNG
TM4 149 4.53x53 μ receptor 6DDE - -
TM4 150 4.54x54 μ receptor 6DDE PAR2 5NDD
TM4 151 4.55x55 μ receptor 6DDE D2 receptor 6CM4
TM4 152 4.56x56 μ receptor 6DDE β2-adrenoceptor 3SN6
TM4 153 4.57x57 AT2 receptor 5UNG PAR2 5NDD
TM4 154 4.58x59 AT2 receptor 5UNG A2A receptor 4UHR
TM4 155 4.59x60 μ receptor 6DDE PAR1 3VW7
TM4 156 4.60x61 μ receptor 6DDE PAR1 3VW7
TM4 157 4.61x62 μ receptor 6DDE PAR1 3VW7
TM4 158 4.62x63 LPA6 receptor 5XSZ PAR1 3VW7
TM4 159 4.63x64 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM4 160 4.64x65 LPA6 receptor 5XSZ - -
ECL2 161 μ receptor 6DDE - -
ECL2 162 μ receptor 6DDE - -
ECL2 163 μ receptor 6DDE - -
ECL2 164 μ receptor 6DDE - -
ECL2 165 μ receptor 6DDE - -
ECL2 166 μ receptor 6DDE - -
ECL2 167 μ receptor 6DDE - -
ECL2 168 μ receptor 6DDE - -
ECL2 169 μ receptor 6DDE - -
ECL2 170 μ receptor 6DDE - -
ECL2 171 - - - -
ECL2 172 45.50x50 μ receptor 6DDE μ receptor 6DDE
ECL2 173 45.51x51 μ receptor 6DDE A2A receptor 4UHR
ECL2 174 45.52x52 μ receptor 6DDE - -
ECL2 175 - - - -
ECL2 176 - - - -
ECL2 177 - - - -
ECL2 178 - - - -
TM5 179 5.30x30 P2Y12 receptor 4NTJ - -
TM5 180 5.31x31 P2Y12 receptor 4NTJ - -
TM5 181 5.32x32 P2Y12 receptor 4NTJ PAR2 5NDD
TM5 182 5.33x33 P2Y12 receptor 4NTJ C5a1 receptor 5O9H
TM5 183 5.34x34 μ receptor 6DDE NTS1 receptor 4XES
TM5 184 5.35x35 μ receptor 6DDE - -
TM5 185 5.36x36 μ receptor 6DDE CCR2 5T1A
TM5 186 5.37x37 μ receptor 6DDE apelin receptor 5VBL
TM5 187 5.38x38 μ receptor 6DDE μ receptor 6DDE
TM5 188 5.39x39 μ receptor 6DDE - -
TM5 189 5.40x40 μ receptor 6DDE BLT1 receptor 5X33
TM5 190 5.41x41 μ receptor 6DDE Y1 receptor 5ZBH
TM5 191 5.42x42 μ receptor 6DDE - -
TM5 192 5.43x43 μ receptor 6DDE PAR2 5NDD
TM5 193 5.44x44 μ receptor 6DDE P2Y1 receptor 4XNW
TM5 194 5.45x45 μ receptor 6DDE PAF receptor 5ZKQ
TM5 195 5.46x46 PAR1 3VW7 PAR1 3VW7
TM5 196 5.47x47 PAR1 3VW7 PAR1 3VW7
TM5 197 5.48x48 μ receptor 6DDE PAR2 5NDD
TM5 198 5.49x49 μ receptor 6DDE P2Y12 receptor 4NTJ
TM5 199 5.50x50 μ receptor 6DDE μ receptor 6DDE
TM5 200 5.51x51 μ receptor 6DDE PAR1 3VW7
TM5 201 5.52x52 μ receptor 6DDE PAR2 5NDD
TM5 202 5.53x53 μ receptor 6DDE μ receptor 6DDE
TM5 203 5.54x54 μ receptor 6DDE 5-HT2B receptor 4IB4
TM5 204 5.55x55 μ receptor 6DDE P2Y12 receptor 4NTJ
TM5 205 5.56x56 μ receptor 6DDE P2Y1 receptor 4XNW
TM5 206 5.57x57 μ receptor 6DDE μ receptor 6DDE
TM5 207 5.58x58 μ receptor 6DDE μ receptor 6DDE
TM5 208 5.59x59 μ receptor 6DDE PAF receptor 5ZKQ
TM5 209 5.60x60 μ receptor 6DDE PAF receptor 5ZKQ
TM5 210 5.61x61 μ receptor 6DDE PAR1 3VW7
TM5 211 5.62x62 μ receptor 6DDE μ receptor 6DDE
TM5 212 5.63x63 μ receptor 6DDE 5-HT2B receptor 4IB4
TM5 213 5.64x64 μ receptor 6DDE - -
TM5 214 5.65x65 μ receptor 6DDE μ receptor 6DDE
TM5 215 5.66x66 μ receptor 6DDE PAF receptor 5ZKQ
TM5 216 5.67x67 μ receptor 6DDE CXCR4 3OE0
TM5 217 5.68x68 μ receptor 6DDE - -
ICL3 218 - - - -
ICL3 219 AT2 receptor 5UNG - -
ICL3 220 - - - -
TM6 221 6.24x24 μ receptor 6DDE μ receptor 6DDF
TM6 222 6.25x25 μ receptor 6DDE - -
TM6 223 6.26x26 μ receptor 6DDE μ receptor 6DDE
TM6 224 6.27x27 μ receptor 6DDE - -
TM6 225 6.28x28 μ receptor 6DDE CCR5 5UIW
TM6 226 6.29x29 μ receptor 6DDE - -
TM6 227 6.30x30 μ receptor 6DDE PAR1 3VW7
TM6 228 6.31x31 μ receptor 6DDE FFA1 receptor 5KW2
TM6 229 6.32x32 μ receptor 6DDE PAR2 5NDD
TM6 230 6.33x33 μ receptor 6DDE - -
TM6 231 6.34x34 μ receptor 6DDE - -
TM6 232 6.35x35 μ receptor 6DDE μ receptor 6DDE
TM6 233 6.36x36 μ receptor 6DDE apelin receptor 5VBL
TM6 234 6.37x37 μ receptor 6DDE LPA6 receptor 5XSZ
TM6 235 6.38x38 μ receptor 6DDE LPA6 receptor 5XSZ
TM6 236 6.39x39 μ receptor 6DDE CCR5 5UIW
TM6 237 6.40x40 μ receptor 6DDE apelin receptor 5VBL
TM6 238 6.41x41 μ receptor 6DDE 5-HT1B receptor 4IAQ
TM6 239 6.42x42 μ receptor 6DDE apelin receptor 5VBL
TM6 240 6.43x43 μ receptor 6DDE - -
TM6 241 6.44x44 μ receptor 6DDE P2Y1 receptor 4XNW
TM6 242 6.45x45 μ receptor 6DDE 5-HT2B receptor 4IB4
TM6 243 6.46x46 μ receptor 6DDE NTS1 receptor 4XES
TM6 244 6.47x47 μ receptor 6DDE PAR1 3VW7
TM6 245 6.48x48 μ receptor 6DDE PAR1 3VW7
TM6 246 6.49x49 μ receptor 6DDE apelin receptor 5VBL
TM6 247 6.50x50 μ receptor 6DDE μ receptor 6DDE
TM6 248 6.51x51 μ receptor 6DDE P2Y1 receptor 4XNW
TM6 249 6.52x52 μ receptor 6DDE μ receptor 6DDE
TM6 250 6.53x53 μ receptor 6DDE μ receptor 6DDE
TM6 251 6.54x54 μ receptor 6DDE - -
TM6 252 6.55x55 μ receptor 6DDE H1 receptor 3RZE
TM6 253 6.56x56 μ receptor 6DDE - -
TM6 254 6.57x57 μ receptor 6DDE A2A receptor 4UHR
TM6 255 6.58x58 μ receptor 6DDE 5-HT2B receptor 4IB4
TM6 256 6.59x59 μ receptor 6DDE apelin receptor 5VBL
TM6 257 6.60x60 μ receptor 6DDE PAF receptor 5ZKQ
TM6 258 6.61x61 μ receptor 6DDE κ receptor 4DJH
ECL3 259 - - - -
ECL3 260 Rhodopsin 5DYS Rhodopsin 5DYS
ECL3 261 Rhodopsin 5DYS - -
ECL3 262 Rhodopsin 5DYS - -
ECL3 263 - - - -
TM7 264 7.31x30 μ receptor 6DDE NTS1 receptor 4XES
TM7 265 7.32x31 μ receptor 6DDE PAF receptor 5ZKQ
TM7 266 7.33x32 μ receptor 6DDE - -
TM7 267 7.34x33 μ receptor 6DDE FFA1 receptor 5TZY
TM7 268 7.35x34 μ receptor 6DDE - -
TM7 269 7.36x35 μ receptor 6DDE CB1 receptor 5XRA
TM7 270 7.37x36 μ receptor 6DDE μ receptor 6DDE
TM7 271 7.38x37 μ receptor 6DDE P2Y1 receptor 4XNW
TM7 272 7.39x38 μ receptor 6DDE 5-HT1B receptor 4IAQ
TM7 273 7.40x39 μ receptor 6DDE Rhodopsin 5DYS
TM7 274 7.41x40 μ receptor 6DDE μ receptor 6DDE
TM7 275 7.42x41 μ receptor 6DDE - -
TM7 276 7.43x42 μ receptor 6DDE - -
TM7 277 7.44x43 μ receptor 6DDE P2Y1 receptor 4XNW
TM7 278 7.45x45 μ receptor 6DDE PAR1 3VW7
TM7 279 7.46x46 μ receptor 6DDE Y1 receptor 5ZBH
TM7 280 7.47x47 μ receptor 6DDE μ receptor 6DDE
TM7 281 7.48x48 μ receptor 6DDE μ receptor 6DDE
TM7 282 7.49x49 μ receptor 6DDE PAR1 3VW7
TM7 283 7.50x50 μ receptor 6DDE - -
TM7 284 7.51x51 μ receptor 6DDE P2Y1 receptor 4XNW
TM7 285 7.52x52 μ receptor 6DDE μ receptor 6DDE
TM7 286 7.53x53 μ receptor 6DDE μ receptor 6DDE
TM7 287 7.54x54 μ receptor 6DDE PAR1 3VW7
TM7 288 7.55x55 LPA6 receptor 5XSZ - -
TM7 289 7.56x56 LPA6 receptor 5XSZ PAR2 5NDD
H8 290 8.47x47 κ receptor 4DJH PAR2 5NDD
H8 291 8.48x48 κ receptor 4DJH 5-HT2B receptor 5TVN
H8 292 8.49x49 κ receptor 4DJH Rhodopsin 5DYS
H8 293 8.50x50 κ receptor 4DJH PAR2 5NDD
H8 294 8.51x51 κ receptor 4DJH AT2 receptor 5UNF
H8 295 8.52x52 κ receptor 4DJH NOP receptor 5DHG
H8 296 8.53x53 κ receptor 4DJH - -
H8 297 8.54x54 κ receptor 4DJH - -
H8 298 8.55x55 κ receptor 4DJH S1P1 receptor 3V2Y
H8 299 8.56x56 κ receptor 4DJH P2Y12 receptor 4NTJ
H8 300 8.57x57 κ receptor 4DJH AT2 receptor 5UNG
H8 301 8.58x58 κ receptor 4DJH - -
H8 302 8.59x59 κ receptor 4DJH apelin receptor 5VBL
H8 303 8.60x60 apelin receptor 5VBL - -
H8 304 8.61x61 apelin receptor 5VBL - -
C-term 305 - - - -
C-term 306 - - - -
C-term 307 - - - -
C-term 308 - - - -
C-term 309 - - - -