GPR19 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 9.67 docs)

VERSION

2018-07-10

MAIN TEMPLATE

κ receptor (sequence similarity: 43%) PDB: 6B73

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 75.0 15.4 9.6
Side-chains 17.1 54.8 28.1

Number of backbone templates: 6
Number of rotamer templates: 37

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6B73
5WS3
4ZJ8
3SN6
4UHR
5WIV
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 59 - - - -
N-term 60 - - - -
N-term 61 κ receptor 6B73 κ receptor 6B73
N-term 62 κ receptor 6B73 κ receptor 6B73
N-term 63 κ receptor 6B73 κ receptor 6B73
TM1 64 1.31x31 κ receptor 6B73 M2 receptor 4MQT
TM1 65 1.32x32 κ receptor 6B73 M2 receptor 4MQT
TM1 66 1.33x33 κ receptor 6B73 A1 receptor 6D9H
TM1 67 1.34x34 κ receptor 6B73 μ receptor 5C1M
TM1 68 1.35x35 κ receptor 6B73 D4 receptor 5WIV
TM1 69 1.36x36 κ receptor 6B73 LPA6 receptor 5XSZ
TM1 70 1.37x37 κ receptor 6B73 β2-adrenoceptor 3SN6
TM1 71 1.38x38 κ receptor 6B73 - -
TM1 72 1.39x39 κ receptor 6B73 LPA6 receptor 5XSZ
TM1 73 1.40x40 κ receptor 6B73 M2 receptor 4MQT
TM1 74 1.41x41 κ receptor 6B73 μ receptor 5C1M
TM1 75 1.42x42 κ receptor 6B73 M2 receptor 4MQT
TM1 76 1.43x43 κ receptor 6B73 - -
TM1 77 1.44x44 κ receptor 6B73 M2 receptor 4MQT
TM1 78 1.45x45 κ receptor 6B73 CB1 receptor 5XRA
TM1 79 1.46x46 κ receptor 6B73 A1 receptor 6D9H
TM1 80 1.47x47 κ receptor 6B73 M2 receptor 4MQT
TM1 81 1.48x48 κ receptor 6B73 μ receptor 5C1M
TM1 82 1.49x49 κ receptor 6B73 κ receptor 6B73
TM1 83 1.50x50 κ receptor 6B73 κ receptor 6B73
TM1 84 1.51x51 κ receptor 6B73 κ receptor 6B73
TM1 85 1.52x52 κ receptor 6B73 κ receptor 6B73
TM1 86 1.53x53 κ receptor 6B73 κ receptor 6B73
TM1 87 1.54x54 κ receptor 6B73 A2A receptor 5G53
TM1 88 1.55x55 κ receptor 6B73 5-HT2B receptor 5TUD
TM1 89 1.56x56 κ receptor 6B73 κ receptor 6B73
TM1 90 1.57x57 κ receptor 6B73 κ receptor 6B73
TM1 91 1.58x58 κ receptor 6B73 - -
TM1 92 1.59x59 κ receptor 6B73 μ receptor 5C1M
TM1 93 1.60x60 κ receptor 6B73 CB1 receptor 5XRA
ICL1 94 12.48x48 - - - -
ICL1 95 12.49x49 OX2 receptor 5WS3 β2-adrenoceptor 4LDE
ICL1 96 12.50x50 OX2 receptor 5WS3 - -
ICL1 97 12.51x51 - - - -
TM2 98 2.37x37 κ receptor 6B73 CCR5 5UIW
TM2 99 2.38x38 κ receptor 6B73 D2 receptor 6CM4
TM2 100 2.39x39 κ receptor 6B73 κ receptor 6B73
TM2 101 2.40x40 κ receptor 6B73 κ receptor 6B73
TM2 102 2.41x41 κ receptor 6B73 M2 receptor 4MQT
TM2 103 2.42x42 κ receptor 6B73 M2 receptor 4MQT
TM2 104 2.43x43 κ receptor 6B73 A2A receptor 5G53
TM2 105 2.44x44 κ receptor 6B73 A2A receptor 5G53
TM2 106 2.45x45 κ receptor 6B73 M2 receptor 4MQT
TM2 107 2.46x46 κ receptor 6B73 - -
TM2 108 2.47x47 κ receptor 6B73 κ receptor 6B73
TM2 109 2.48x48 κ receptor 6B73 M2 receptor 4MQT
TM2 110 2.49x49 κ receptor 6B73 κ receptor 6B73
TM2 111 2.50x50 κ receptor 6B73 κ receptor 6B73
TM2 112 2.51x51 κ receptor 6B73 M2 receptor 4MQT
TM2 113 2.52x52 κ receptor 6B73 κ receptor 6B73
TM2 114 2.53x53 κ receptor 6B73 M2 receptor 4MQT
TM2 115 2.54x54 κ receptor 6B73 5-HT1B receptor 6G79
TM2 116 2.55x55 OX2 receptor 5WS3 M2 receptor 4MQT
TM2 117 2.56x551 OX2 receptor 5WS3 β2-adrenoceptor 3SN6
TM2 118 2.57x56 OX2 receptor 5WS3 M2 receptor 4MQT
TM2 119 2.58x57 κ receptor 6B73 - -
TM2 120 2.59x58 κ receptor 6B73 κ receptor 6B73
TM2 121 2.60x59 κ receptor 6B73 κ receptor 6B73
TM2 122 2.61x60 κ receptor 6B73 D2 receptor 6CM4
TM2 123 2.62x61 κ receptor 6B73 Rhodopsin 5DYS
TM2 124 2.63x62 κ receptor 6B73 M2 receptor 4MQT
TM2 125 2.64x63 κ receptor 6B73 - -
TM2 126 2.65x64 κ receptor 6B73 NTS1 receptor 5T04
TM2 127 2.66x65 κ receptor 6B73 A2A receptor 5G53
TM2 128 2.67x66 κ receptor 6B73 β2-adrenoceptor 3SN6
TM2 129 2.68x67 OX2 receptor 5WS3 μ receptor 6DDF
ECL1 130 23.49x49 - - - -
ECL1 131 23.50x50 OX2 receptor 5WS3 OX2 receptor 5WS3
ECL1 132 23.51x51 OX2 receptor 5WS3 β2-adrenoceptor 3SN6
ECL1 133 23.52x52 - - - -
TM3 134 3.21x21 κ receptor 6B73 κ receptor 6B73
TM3 135 3.22x22 κ receptor 6B73 LPA6 receptor 5XSZ
TM3 136 3.23x23 κ receptor 6B73 NTS1 receptor 5T04
TM3 137 3.24x24 κ receptor 6B73 A1 receptor 6D9H
TM3 138 3.25x25 κ receptor 6B73 κ receptor 6B73
TM3 139 3.26x26 κ receptor 6B73 κ receptor 6B73
TM3 140 3.27x27 κ receptor 6B73 5-HT2C receptor 6BQG
TM3 141 3.28x28 κ receptor 6B73 κ receptor 6B73
TM3 142 3.29x29 κ receptor 6B73 P2Y1 receptor 4XNW
TM3 143 3.30x30 κ receptor 6B73 OX2 receptor 5WS3
TM3 144 3.31x31 κ receptor 6B73 Rhodopsin 5DYS
TM3 145 3.32x32 κ receptor 6B73 OX2 receptor 5WS3
TM3 146 3.33x33 κ receptor 6B73 κ receptor 6B73
TM3 147 3.34x34 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 148 3.35x35 κ receptor 6B73 P2Y12 receptor 4NTJ
TM3 149 3.36x36 κ receptor 6B73 - -
TM3 150 3.37x37 κ receptor 6B73 ETB receptor 5X93
TM3 151 3.38x38 κ receptor 6B73 OX2 receptor 5WS3
TM3 152 3.39x39 κ receptor 6B73 - -
TM3 153 3.40x40 κ receptor 6B73 κ receptor 6B73
TM3 154 3.41x41 κ receptor 6B73 - -
TM3 155 3.42x42 κ receptor 6B73 - -
TM3 156 3.43x43 κ receptor 6B73 κ receptor 6B73
TM3 157 3.44x44 κ receptor 6B73 M2 receptor 4MQT
TM3 158 3.45x45 κ receptor 6B73 NTS1 receptor 5T04
TM3 159 3.46x46 κ receptor 6B73 M2 receptor 4MQT
TM3 160 3.47x47 κ receptor 6B73 H1 receptor 3RZE
TM3 161 3.48x48 κ receptor 6B73 Rhodopsin 5DYS
TM3 162 3.49x49 κ receptor 6B73 κ receptor 6B73
TM3 163 3.50x50 κ receptor 6B73 κ receptor 6B73
TM3 164 3.51x51 κ receptor 6B73 LPA6 receptor 5XSZ
TM3 165 3.52x52 κ receptor 6B73 US28 4XT1
TM3 166 3.53x53 κ receptor 6B73 S1P1 receptor 3V2Y
TM3 167 3.54x54 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 168 3.55x55 κ receptor 6B73 LPA6 receptor 5XSZ
TM3 169 3.56x56 κ receptor 6B73 LPA6 receptor 5XSZ
ICL2 170 34.50x50 - - - -
ICL2 171 34.51x51 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
ICL2 172 34.52x52 OX1 receptor 4ZJ8 Rhodopsin 4ZWJ
ICL2 173 34.53x53 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
ICL2 174 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
ICL2 175 - - - -
TM4 176 4.38x38 κ receptor 6B73 NTS1 receptor 5T04
TM4 177 4.39x39 κ receptor 6B73 NTS1 receptor 5T04
TM4 178 4.40x40 κ receptor 6B73 - -
TM4 179 4.41x41 κ receptor 6B73 κ receptor 6B73
TM4 180 4.42x42 κ receptor 6B73 κ receptor 6B73
TM4 181 4.43x43 κ receptor 6B73 κ receptor 6B73
TM4 182 4.44x44 κ receptor 6B73 NTS1 receptor 5T04
TM4 183 4.45x45 κ receptor 6B73 M2 receptor 4MQT
TM4 184 4.46x46 κ receptor 6B73 M2 receptor 4MQT
TM4 185 4.47x47 κ receptor 6B73 M2 receptor 4MQT
TM4 186 4.48x48 κ receptor 6B73 M2 receptor 4MQT
TM4 187 4.49x49 κ receptor 6B73 - -
TM4 188 4.50x50 κ receptor 6B73 κ receptor 6B73
TM4 189 4.51x51 κ receptor 6B73 M2 receptor 4MQT
TM4 190 4.52x52 κ receptor 6B73 5-HT1B receptor 6G79
TM4 191 4.53x53 κ receptor 6B73 - -
TM4 192 4.54x54 κ receptor 6B73 NTS1 receptor 5T04
TM4 193 4.55x55 κ receptor 6B73 5-HT2B receptor 5TUD
TM4 194 4.56x56 κ receptor 6B73 - -
TM4 195 4.57x57 OX2 receptor 5WS3 PAR1 3VW7
TM4 196 4.58x59 OX2 receptor 5WS3 A2A receptor 5G53
TM4 197 4.59x60 κ receptor 6B73 β2-adrenoceptor 3SN6
TM4 198 4.60x61 κ receptor 6B73 5-HT2B receptor 5TUD
TM4 199 4.61x62 κ receptor 6B73 M2 receptor 4MQT
TM4 200 4.62x63 κ receptor 6B73 M2 receptor 4MQT
TM4 201 4.63x64 κ receptor 6B73 - -
TM4 202 4.64x65 OX2 receptor 5WS3 - -
ECL2 203 - - - -
ECL2 204 - - - -
ECL2 205 - - - -
ECL2 206 - - - -
ECL2 207 - - - -
ECL2 208 - - - -
ECL2 209 - - - -
ECL2 210 45.50x50 κ receptor 6B73 κ receptor 6B73
ECL2 211 45.51x51 κ receptor 6B73 - -
ECL2 212 45.52x52 κ receptor 6B73 - -
ECL2 213 - - - -
ECL2 214 OX2 receptor 5WS3 - -
ECL2 215 OX2 receptor 5WS3 - -
ECL2 216 OX2 receptor 5WS3 - -
ECL2 217 - - - -
TM5 218 5.33x34 κ receptor 6B73 κ receptor 6B73
TM5 219 5.34x35 κ receptor 6B73 - -
TM5 220 5.35x36 κ receptor 6B73 NOP receptor 5DHG
TM5 221 5.36x37 κ receptor 6B73 H1 receptor 3RZE
TM5 222 5.37x38 κ receptor 6B73 M2 receptor 4MQT
TM5 223 5.38x39 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 224 5.39x40 κ receptor 6B73 M2 receptor 4MQT
TM5 225 5.40x41 κ receptor 6B73 5-HT1B receptor 6G79
TM5 226 5.41x42 κ receptor 6B73 5-HT2C receptor 6BQG
TM5 227 5.42x43 κ receptor 6B73 CXCR4 3ODU
TM5 228 5.43x44 κ receptor 6B73 κ receptor 6B73
TM5 229 5.44x45 κ receptor 6B73 5-HT2B receptor 5TUD
TM5 230 5.45x46 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 231 5.46x461 κ receptor 6B73 LPA6 receptor 5XSZ
TM5 232 5.47x47 κ receptor 6B73 κ receptor 6B73
TM5 233 5.48x48 κ receptor 6B73 κ receptor 6B73
TM5 234 5.49x49 κ receptor 6B73 κ receptor 6B73
TM5 235 5.50x50 κ receptor 6B73 κ receptor 6B73
TM5 236 5.51x51 κ receptor 6B73 - -
TM5 237 5.52x52 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 238 5.53x53 κ receptor 6B73 5-HT1B receptor 6G79
TM5 239 5.54x54 κ receptor 6B73 κ receptor 6B73
TM5 240 5.55x55 κ receptor 6B73 κ receptor 6B73
TM5 241 5.56x56 κ receptor 6B73 A1 receptor 6D9H
TM5 242 5.57x57 κ receptor 6B73 H1 receptor 3RZE
TM5 243 5.58x58 κ receptor 6B73 κ receptor 6B73
TM5 244 5.59x59 κ receptor 6B73 - -
TM5 245 5.60x60 κ receptor 6B73 Y1 receptor 5ZBH
TM5 246 5.61x61 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 247 5.62x62 κ receptor 6B73 κ receptor 6B73
TM5 248 5.63x63 κ receptor 6B73 AT2 receptor 5UNG
TM5 249 5.64x64 κ receptor 6B73 LPA1 receptor 4Z35
TM5 250 5.65x65 κ receptor 6B73 A1 receptor 6D9H
TM5 251 5.66x66 κ receptor 6B73 OX2 receptor 5WS3
TM5 252 5.67x67 κ receptor 6B73 A2A receptor 5G53
TM5 253 5.68x68 β2-adrenoceptor 3SN6 - -
TM5 254 5.69x69 β2-adrenoceptor 3SN6 - -
TM5 255 5.70x70 β2-adrenoceptor 3SN6 - -
TM5 256 5.71x71 β2-adrenoceptor 3SN6 - -
TM5 257 5.72x72 β2-adrenoceptor 3SN6 - -
TM5 258 5.73x73 β2-adrenoceptor 3SN6 - -
ICL3 259 - - - -
ICL3 260 - - - -
ICL3 261 - - - -
ICL3 262 - - - -
TM6 263 6.22x22 A2A receptor 4UHR - -
TM6 264 6.23x23 κ receptor 6B73 - -
TM6 265 6.24x24 κ receptor 6B73 - -
TM6 266 6.25x25 κ receptor 6B73 - -
TM6 267 6.26x26 κ receptor 6B73 - -
TM6 268 6.27x27 κ receptor 6B73 - -
TM6 269 6.28x28 κ receptor 6B73 μ receptor 6DDF
TM6 270 6.29x29 κ receptor 6B73 AT2 receptor 5UNG
TM6 271 6.30x30 κ receptor 6B73 LPA6 receptor 5XSZ
TM6 272 6.31x31 κ receptor 6B73 A2A receptor 5G53
TM6 273 6.32x32 κ receptor 6B73 M2 receptor 4MQT
TM6 274 6.33x33 κ receptor 6B73 OX2 receptor 5WS3
TM6 275 6.34x34 κ receptor 6B73 - -
TM6 276 6.35x35 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 277 6.36x36 κ receptor 6B73 μ receptor 5C1M
TM6 278 6.37x37 κ receptor 6B73 - -
TM6 279 6.38x38 κ receptor 6B73 κ receptor 6B73
TM6 280 6.39x39 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 281 6.40x40 κ receptor 6B73 apelin receptor 5VBL
TM6 282 6.41x41 κ receptor 6B73 - -
TM6 283 6.42x42 κ receptor 6B73 M2 receptor 4MQT
TM6 284 6.43x43 κ receptor 6B73 A2A receptor 5G53
TM6 285 6.44x44 κ receptor 6B73 κ receptor 6B73
TM6 286 6.45x45 κ receptor 6B73 Rhodopsin 5DYS
TM6 287 6.46x46 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 288 6.47x47 κ receptor 6B73 A1 receptor 6D9H
TM6 289 6.48x48 κ receptor 6B73 κ receptor 6B73
TM6 290 6.49x49 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 291 6.50x50 κ receptor 6B73 κ receptor 6B73
TM6 292 6.51x51 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 293 6.52x52 κ receptor 6B73 κ receptor 6B73
TM6 294 6.53x53 κ receptor 6B73 M2 receptor 4MQT
TM6 295 6.54x54 κ receptor 6B73 ETB receptor 5X93
TM6 296 6.55x55 κ receptor 6B73 PAF receptor 5ZKP
TM6 297 6.56x56 κ receptor 6B73 κ receptor 6B73
TM6 298 6.57x57 κ receptor 6B73 - -
TM6 299 6.58x58 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 300 6.59x59 κ receptor 6B73 5-HT1B receptor 4IAQ
TM6 301 6.60x60 κ receptor 6B73 - -
TM6 302 6.61x61 κ receptor 6B73 - -
ECL3 303 - - - -
ECL3 304 D4 receptor 5WIV - -
ECL3 305 D4 receptor 5WIV - -
ECL3 306 D4 receptor 5WIV - -
ECL3 307 - - - -
TM7 308 7.31x30 κ receptor 6B73 - -
TM7 309 7.32x31 κ receptor 6B73 A1 receptor 6D9H
TM7 310 7.33x32 κ receptor 6B73 AT2 receptor 5UNG
TM7 311 7.34x33 κ receptor 6B73 M2 receptor 4MQT
TM7 312 7.35x34 κ receptor 6B73 5-HT1B receptor 6G79
TM7 313 7.36x35 κ receptor 6B73 M2 receptor 4MQT
TM7 314 7.37x36 κ receptor 6B73 D2 receptor 6CM4
TM7 315 7.38x37 κ receptor 6B73 - -
TM7 316 7.39x38 κ receptor 6B73 5-HT1B receptor 6G79
TM7 317 7.40x39 κ receptor 6B73 M2 receptor 4MQT
TM7 318 7.41x40 κ receptor 6B73 β2-adrenoceptor 3SN6
TM7 319 7.42x41 κ receptor 6B73 A2A receptor 5G53
TM7 320 7.43x42 κ receptor 6B73 AT2 receptor 5UNG
TM7 321 7.44x43 κ receptor 6B73 Rhodopsin 4ZWJ
TM7 322 7.45x45 κ receptor 6B73 Rhodopsin 5DYS
TM7 323 7.46x46 κ receptor 6B73 κ receptor 6B73
TM7 324 7.47x47 κ receptor 6B73 NTS1 receptor 5T04
TM7 325 7.48x48 κ receptor 6B73 - -
TM7 326 7.49x49 κ receptor 6B73 - -
TM7 327 7.50x50 κ receptor 6B73 κ receptor 6B73
TM7 328 7.51x51 κ receptor 6B73 - -
TM7 329 7.52x52 OX2 receptor 5WS3 μ receptor 6DDF
TM7 330 7.53x53 OX2 receptor 5WS3 OX2 receptor 5WS3
TM7 331 7.54x54 OX2 receptor 5WS3 LPA1 receptor 4Z35
TM7 332 7.55x55 OX2 receptor 5WS3 - -
TM7 333 7.56x56 OX2 receptor 5WS3 - -
H8 334 8.47x47 OX2 receptor 5WS3 M2 receptor 4MQT
H8 335 8.48x48 OX2 receptor 5WS3 M2 receptor 4MQT
H8 336 8.49x49 OX2 receptor 5WS3 κ receptor 4DJH
H8 337 8.50x50 OX2 receptor 5WS3 OX2 receptor 5WS3
H8 338 8.51x51 OX2 receptor 5WS3 OX2 receptor 5WS3
H8 339 8.52x52 OX2 receptor 5WS3 5-HT2C receptor 6BQG
H8 340 8.53x53 OX2 receptor 5WS3 - -
H8 341 8.54x54 OX2 receptor 5WS3 Rhodopsin 5DYS
H8 342 8.55x55 OX2 receptor 5WS3 M2 receptor 4MQT
H8 343 8.56x56 OX2 receptor 5WS3 β2-adrenoceptor 3SN6
H8 344 8.57x57 OX2 receptor 5WS3 Rhodopsin 5DYS
H8 345 8.58x58 OX2 receptor 5WS3 OX2 receptor 5WS3
C-term 346 - - - -
C-term 347 - - - -
C-term 348 - - - -
C-term 349 - - - -
C-term 350 - - - -