GPR3 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 7.98 docs)

VERSION

2018-07-10

MAIN TEMPLATE

CB1 receptor (sequence similarity: 41%) PDB: 5XRA

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 76.6 11.2 12.2
Side-chains 23.8 53.1 23.1

Number of backbone templates: 7
Number of rotamer templates: 35

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5XRA
3V2Y
4NTJ
3PBL
3SN6
4UHR
6CM4
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 33 CB1 receptor 5XRA CB1 receptor 5XRA
N-term 34 CB1 receptor 5XRA CB1 receptor 5XRA
N-term 35 CB1 receptor 5XRA CB1 receptor 5XRA
N-term 36 CB1 receptor 5XRA CB1 receptor 5XRA
N-term 37 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 38 1.30x30 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM1 39 1.31x31 CB1 receptor 5XRA NTS1 receptor 5T04
TM1 40 1.32x32 CB1 receptor 5XRA κ receptor 6B73
TM1 41 1.33x33 CB1 receptor 5XRA S1P1 receptor 3V2Y
TM1 42 1.34x34 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 43 1.35x35 CB1 receptor 5XRA 5-HT2B receptor 4IB4
TM1 44 1.36x36 CB1 receptor 5XRA - -
TM1 45 1.37x37 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 46 1.38x38 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM1 47 1.39x39 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM1 48 1.40x40 CB1 receptor 5XRA D3 receptor 3PBL
TM1 49 1.41x41 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM1 50 1.42x42 CB1 receptor 5XRA BLT1 receptor 5X33
TM1 51 1.43x43 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 52 1.44x44 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 53 1.45x45 CB1 receptor 5XRA A2A receptor 5G53
TM1 54 1.46x46 CB1 receptor 5XRA D4 receptor 5WIV
TM1 55 1.47x47 CB1 receptor 5XRA US28 4XT1
TM1 56 1.48x48 CB1 receptor 5XRA - -
TM1 57 1.49x49 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 58 1.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 59 1.51x51 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM1 60 1.52x52 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 61 1.53x53 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 62 1.54x54 CB1 receptor 5XRA AT2 receptor 5UNG
TM1 63 1.55x55 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM1 64 1.56x56 CB1 receptor 5XRA LPA6 receptor 5XSZ
TM1 65 1.57x57 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 66 1.58x58 CB1 receptor 5XRA Rhodopsin 5DYS
TM1 67 1.59x59 CB1 receptor 5XRA - -
TM1 68 1.60x60 CB1 receptor 5XRA - -
ICL1 69 12.48x48 - - - -
ICL1 70 12.49x49 S1P1 receptor 3V2Y D2 receptor 6CM4
ICL1 71 12.50x50 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
ICL1 72 12.51x51 - - - -
TM2 73 2.37x37 S1P1 receptor 3V2Y PAR2 5NDD
TM2 74 2.38x38 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM2 75 2.39x39 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM2 76 2.40x40 CB1 receptor 5XRA A1 receptor 6D9H
TM2 77 2.41x41 CB1 receptor 5XRA H1 receptor 3RZE
TM2 78 2.42x42 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM2 79 2.43x43 CB1 receptor 5XRA A2A receptor 5G53
TM2 80 2.44x44 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 81 2.45x45 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 82 2.46x46 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 83 2.47x47 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 84 2.48x48 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 85 2.49x49 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 86 2.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 87 2.51x51 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 88 2.52x52 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 89 2.53x53 CB1 receptor 5XRA μ receptor 5C1M
TM2 90 2.54x54 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM2 91 2.55x55 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM2 92 2.56x56 CB1 receptor 5XRA Rhodopsin 5DYS
TM2 93 2.57x57 CB1 receptor 5XRA μ receptor 5C1M
TM2 94 2.58x58 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 95 2.59x59 CB1 receptor 5XRA A1 receptor 6D9H
TM2 96 2.60x60 CB1 receptor 5XRA - -
TM2 97 2.61x61 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 98 2.62x62 CB1 receptor 5XRA β2-adrenoceptor 3SN6
ECL1 99 - - - -
ECL1 100 23.49x49 S1P1 receptor 3V2Y - -
ECL1 101 23.50x50 S1P1 receptor 3V2Y - -
ECL1 102 23.51x51 S1P1 receptor 3V2Y - -
ECL1 103 23.52x52 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM3 104 3.20x20 P2Y12 receptor 4NTJ - -
TM3 105 3.21x21 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 106 3.22x22 CB1 receptor 5XRA ETB receptor 5X93
TM3 107 3.23x23 CB1 receptor 5XRA ETB receptor 5X93
TM3 108 3.24x24 CB1 receptor 5XRA AT2 receptor 5UNG
TM3 109 3.25x25 CB1 receptor 5XRA - -
TM3 110 3.26x26 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 111 3.27x27 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM3 112 3.28x28 CB1 receptor 5XRA US28 4XT1
TM3 113 3.29x29 CB1 receptor 5XRA LPA6 receptor 5XSZ
TM3 114 3.30x30 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 115 3.31x31 CB1 receptor 5XRA Y1 receptor 5ZBH
TM3 116 3.32x32 CB1 receptor 5XRA AT2 receptor 5UNG
TM3 117 3.33x33 CB1 receptor 5XRA OX1 receptor 4ZJ8
TM3 118 3.34x34 CB1 receptor 5XRA D2 receptor 6CM4
TM3 119 3.35x35 CB1 receptor 5XRA US28 4XT1
TM3 120 3.36x36 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 121 3.37x37 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 122 3.38x38 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 123 3.39x39 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 124 3.40x40 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM3 125 3.41x41 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 126 3.42x42 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 127 3.43x43 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 128 3.44x44 CB1 receptor 5XRA A2A receptor 5G53
TM3 129 3.45x45 CB1 receptor 5XRA A2A receptor 5G53
TM3 130 3.46x46 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM3 131 3.47x47 CB1 receptor 5XRA PAF receptor 5ZKP
TM3 132 3.48x48 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM3 133 3.49x49 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 134 3.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 135 3.51x51 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 136 3.52x52 CB1 receptor 5XRA A1 receptor 6D9H
TM3 137 3.53x53 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 138 3.54x54 CB1 receptor 5XRA - -
TM3 139 3.55x55 CB1 receptor 5XRA - -
TM3 140 3.56x56 CB1 receptor 5XRA 5-HT2C receptor 6BQG
ICL2 141 34.50x50 - - - -
ICL2 142 34.51x51 D3 receptor 3PBL CB1 receptor 5XRA
ICL2 143 34.52x52 D3 receptor 3PBL M2 receptor 4MQT
ICL2 144 34.53x53 D3 receptor 3PBL D3 receptor 3PBL
ICL2 145 34.54x54 D3 receptor 3PBL - -
ICL2 146 34.55x55 D3 receptor 3PBL β2-adrenoceptor 3SN6
ICL2 147 34.56x56 D3 receptor 3PBL - -
ICL2 148 34.57x57 - - - -
TM4 149 4.38x38 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 150 4.39x39 CB1 receptor 5XRA US28 4XT1
TM4 151 4.40x40 CB1 receptor 5XRA A2A receptor 5G53
TM4 152 4.41x41 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM4 153 4.42x42 CB1 receptor 5XRA NTS1 receptor 5T04
TM4 154 4.43x43 CB1 receptor 5XRA Y1 receptor 5ZBH
TM4 155 4.44x44 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 156 4.45x45 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM4 157 4.46x46 CB1 receptor 5XRA BLT1 receptor 5X33
TM4 158 4.47x47 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM4 159 4.48x48 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 160 4.49x49 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM4 161 4.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 162 4.51x51 CB1 receptor 5XRA BLT1 receptor 5X33
TM4 163 4.52x52 CB1 receptor 5XRA - -
TM4 164 4.53x53 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 165 4.54x54 CB1 receptor 5XRA Rhodopsin 5DYS
TM4 166 4.55x55 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM4 167 4.56x56 CB1 receptor 5XRA NTS1 receptor 5T04
TM4 168 4.57x57 CB1 receptor 5XRA A2A receptor 5G53
TM4 169 4.58x58 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM4 170 4.59x59 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 171 4.60x60 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 172 4.61x61 CB1 receptor 5XRA 5-HT2B receptor 5TUD
TM4 173 4.62x62 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 174 4.63x63 CB1 receptor 5XRA BLT1 receptor 5X33
ECL2 175 - - - -
ECL2 176 - - - -
ECL2 177 - - - -
ECL2 178 - - - -
ECL2 179 - - - -
ECL2 180 - - - -
ECL2 181 - - - -
ECL2 182 - - - -
ECL2 183 - - - -
ECL2 184 - - - -
ECL2 185 - - - -
ECL2 186 - - - -
ECL2 187 - - - -
ECL2 188 - - - -
ECL2 189 - - - -
ECL2 190 - - - -
TM5 191 5.36x36 CB1 receptor 5XRA A1 receptor 6D9H
TM5 192 5.37x37 CB1 receptor 5XRA CB1 receptor 5XRA
TM5 193 5.38x38 CB1 receptor 5XRA A2A receptor 5G53
TM5 194 5.39x39 CB1 receptor 5XRA BLT1 receptor 5X33
TM5 195 5.40x40 CB1 receptor 5XRA CB1 receptor 5XRA
TM5 196 5.41x41 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM5 197 5.42x42 CB1 receptor 5XRA NTS1 receptor 5T04
TM5 198 5.43x43 CB1 receptor 5XRA US28 4XT1
TM5 199 5.44x44 CB1 receptor 5XRA M2 receptor 4MQT
TM5 200 5.45x45 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM5 201 5.46x46 CB1 receptor 5XRA A2A receptor 5G53
TM5 202 5.47x47 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM5 203 5.48x48 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM5 204 5.49x49 CB1 receptor 5XRA μ receptor 5C1M
TM5 205 5.50x50 CB1 receptor 5XRA PAF receptor 5ZKP
TM5 206 5.51x51 CB1 receptor 5XRA PAF receptor 5ZKP
TM5 207 5.52x52 CB1 receptor 5XRA D3 receptor 3PBL
TM5 208 5.53x53 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM5 209 5.54x54 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM5 210 5.55x55 CB1 receptor 5XRA A2A receptor 5G53
TM5 211 5.56x56 CB1 receptor 5XRA - -
TM5 212 5.57x57 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM5 213 5.58x58 CB1 receptor 5XRA CB1 receptor 5XRA
TM5 214 5.59x59 CB1 receptor 5XRA LPA6 receptor 5XSZ
TM5 215 5.60x60 CB1 receptor 5XRA Rhodopsin 5DYS
TM5 216 5.61x61 CB1 receptor 5XRA CB1 receptor 5XRA
TM5 217 5.62x62 CB1 receptor 5XRA - -
TM5 218 5.63x63 CB1 receptor 5XRA M2 receptor 4MQT
TM5 219 5.64x64 CB1 receptor 5XRA US28 4XT1
TM5 220 5.65x65 CB1 receptor 5XRA Rhodopsin 5DYS
TM5 221 5.66x66 CB1 receptor 5XRA - -
TM5 222 5.67x67 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM5 223 5.68x68 CB1 receptor 5XRA CB1 receptor 5XRA
TM5 224 5.69x69 CB1 receptor 5XRA CB1 receptor 5XRA
TM5 225 5.70x70 β2-adrenoceptor 3SN6 β2-adrenoceptor 3SN6
TM5 226 5.71x71 β2-adrenoceptor 3SN6 Rhodopsin 5DYS
TM5 227 5.72x72 β2-adrenoceptor 3SN6 β2-adrenoceptor 3SN6
TM5 228 5.73x73 β2-adrenoceptor 3SN6 - -
ICL3 229 - - - -
ICL3 230 - - - -
ICL3 231 - - - -
ICL3 232 - - - -
ICL3 233 - - - -
TM6 234 6.22x22 A2A receptor 4UHR - -
TM6 235 6.23x23 A2A receptor 4UHR - -
TM6 236 6.24x24 A2A receptor 4UHR Rhodopsin 5DYS
TM6 237 6.25x25 A2A receptor 4UHR A2A receptor 4UHR
TM6 238 6.26x26 A2A receptor 4UHR ETB receptor 5X93
TM6 239 6.27x27 A2A receptor 4UHR A1 receptor 6D9H
TM6 240 6.28x28 A2A receptor 4UHR M1 receptor 5CXV
TM6 241 6.29x29 A2A receptor 4UHR Rhodopsin 5DYS
TM6 242 6.30x30 CB1 receptor 5XRA Y1 receptor 5ZBH
TM6 243 6.31x31 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM6 244 6.32x32 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM6 245 6.33x33 CB1 receptor 5XRA NTS1 receptor 5T04
TM6 246 6.34x34 CB1 receptor 5XRA - -
TM6 247 6.35x35 CB1 receptor 5XRA FFA1 receptor 5TZY
TM6 248 6.36x36 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 249 6.37x37 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 250 6.38x38 CB1 receptor 5XRA A2A receptor 5G53
TM6 251 6.39x39 CB1 receptor 5XRA κ receptor 6B73
TM6 252 6.40x40 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM6 253 6.41x41 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 254 6.42x42 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM6 255 6.43x43 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM6 256 6.44x44 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM6 257 6.45x45 CB1 receptor 5XRA A2A receptor 5G53
TM6 258 6.46x46 CB1 receptor 5XRA S1P1 receptor 3V2Y
TM6 259 6.47x47 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 260 6.48x48 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 261 6.49x49 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM6 262 6.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 263 6.51x51 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM6 264 6.52x52 CB1 receptor 5XRA Y1 receptor 5ZBH
TM6 265 6.53x53 CB1 receptor 5XRA NTS1 receptor 5T04
TM6 266 6.54x54 CB1 receptor 5XRA μ receptor 5C1M
TM6 267 6.55x55 CB1 receptor 5XRA - -
TM6 268 6.56x56 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM6 269 6.57x57 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM6 270 6.58x58 CB1 receptor 5XRA - -
TM6 271 6.59x59 CB1 receptor 5XRA Y1 receptor 5ZBH
TM6 272 6.60x60 CB1 receptor 5XRA - -
TM6 273 6.61x61 CB1 receptor 5XRA Rhodopsin 4ZWJ
ECL3 274 - - - -
ECL3 275 - - - -
ECL3 276 - - - -
ECL3 277 - - - -
TM7 278 7.34x33 CB1 receptor 5XRA M3 receptor 4U15
TM7 279 7.35x34 CB1 receptor 5XRA A1 receptor 6D9H
TM7 280 7.36x35 CB1 receptor 5XRA A2A receptor 5G53
TM7 281 7.37x36 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM7 282 7.38x37 CB1 receptor 5XRA NTS1 receptor 5T04
TM7 283 7.39x38 CB1 receptor 5XRA LPA6 receptor 5XSZ
TM7 284 7.40x39 CB1 receptor 5XRA AT2 receptor 5UNG
TM7 285 7.41x40 CB1 receptor 5XRA - -
TM7 286 7.42x41 CB1 receptor 5XRA Rhodopsin 5DYS
TM7 287 7.43x42 CB1 receptor 5XRA PAR2 5NDD
TM7 288 7.44x43 CB1 receptor 5XRA - -
TM7 289 7.45x45 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 290 7.46x46 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 291 7.47x47 CB1 receptor 5XRA - -
TM7 292 7.48x48 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM7 293 7.49x49 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 294 7.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 295 7.51x51 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 296 7.52x52 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 297 7.53x53 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 298 7.54x54 S1P1 receptor 3V2Y A2A receptor 5G53
TM7 299 7.55x55 S1P1 receptor 3V2Y A1 receptor 6D9H
TM7 300 7.56x56 S1P1 receptor 3V2Y A2A receptor 5G53
H8 301 8.47x47 CB1 receptor 5XRA 5-HT1B receptor 6G79
H8 302 8.48x48 CB1 receptor 5XRA A1 receptor 6D9H
H8 303 8.49x49 CB1 receptor 5XRA CB1 receptor 5XRA
H8 304 8.50x50 CB1 receptor 5XRA - -
H8 305 8.51x51 CB1 receptor 5XRA AT2 receptor 5UNF
H8 306 8.52x52 CB1 receptor 5XRA D3 receptor 3PBL
H8 307 8.53x53 CB1 receptor 5XRA D4 receptor 5WIV
H8 308 8.54x54 CB1 receptor 5XRA AT2 receptor 5UNG
H8 309 8.55x55 CB1 receptor 5XRA - -
H8 310 8.56x56 CB1 receptor 5XRA OX2 receptor 5WS3
H8 311 8.57x57 CB1 receptor 5XRA AT2 receptor 5UNG
H8 312 8.58x58 CB1 receptor 5XRA - -
H8 313 8.59x59 D2 receptor 6CM4 β2-adrenoceptor 5JQH
C-term 314 - - - -
C-term 315 - - - -
C-term 316 - - - -
C-term 317 - - - -
C-term 318 - - - -