HCA2 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 9.79 docs)

VERSION

2018-07-10

MAIN TEMPLATE

κ receptor (sequence similarity: 47%) PDB: 6B73

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 77.0 16.6 6.4
Side-chains 21.6 55.1 23.3

Number of backbone templates: 5
Number of rotamer templates: 37

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6B73
4DJH
4XNW
5VBL
5UIW
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 20 - - - -
N-term 21 - - - -
N-term 22 κ receptor 6B73 κ receptor 6B73
N-term 23 κ receptor 6B73 κ receptor 6B73
N-term 24 κ receptor 6B73 κ receptor 6B73
TM1 25 1.30x30 κ receptor 6B73 PAF receptor 5ZKP
TM1 26 1.31x31 κ receptor 6B73 κ receptor 6B73
TM1 27 1.32x32 κ receptor 6B73 β2-adrenoceptor 3SN6
TM1 28 1.33x33 κ receptor 6B73 LPA1 receptor 4Z35
TM1 29 1.34x34 κ receptor 6B73 US28 4XT1
TM1 30 1.35x35 κ receptor 6B73 Rhodopsin 5DYS
TM1 31 1.36x36 κ receptor 6B73 AT2 receptor 5UNG
TM1 32 1.37x37 κ receptor 6B73 CCR2 5T1A
TM1 33 1.38x38 κ receptor 6B73 κ receptor 6B73
TM1 34 1.39x39 κ receptor 6B73 5-HT2B receptor 5TUD
TM1 35 1.40x40 κ receptor 6B73 US28 4XT1
TM1 36 1.41x41 κ receptor 6B73 5-HT2B receptor 5TUD
TM1 37 1.42x42 κ receptor 6B73 - -
TM1 38 1.43x43 κ receptor 6B73 κ receptor 6B73
TM1 39 1.44x44 κ receptor 6B73 5-HT2B receptor 5TUD
TM1 40 1.45x45 κ receptor 6B73 US28 4XT1
TM1 41 1.46x46 κ receptor 6B73 κ receptor 6B73
TM1 42 1.47x47 κ receptor 6B73 κ receptor 6B73
TM1 43 1.48x48 κ receptor 6B73 AT2 receptor 5UNG
TM1 44 1.49x49 κ receptor 6B73 κ receptor 6B73
TM1 45 1.50x50 κ receptor 6B73 κ receptor 6B73
TM1 46 1.51x51 κ receptor 6B73 PAF receptor 5ZKP
TM1 47 1.52x52 κ receptor 6B73 κ receptor 6B73
TM1 48 1.53x53 κ receptor 6B73 LPA6 receptor 5XSZ
TM1 49 1.54x54 κ receptor 6B73 PAF receptor 5ZKP
TM1 50 1.55x55 κ receptor 6B73 PAF receptor 5ZKP
TM1 51 1.56x56 κ receptor 6B73 LPA6 receptor 5XSZ
TM1 52 1.57x57 κ receptor 6B73 LPA6 receptor 5XSZ
TM1 53 1.58x58 κ receptor 6B73 AT2 receptor 5UNG
TM1 54 1.59x59 κ receptor 6B73 P2Y1 receptor 4XNW
TM1 55 1.60x60 κ receptor 6B73 P2Y1 receptor 4XNW
ICL1 56 - - - -
ICL1 57 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
ICL1 58 P2Y1 receptor 4XNW - -
ICL1 59 - - - -
TM2 60 2.37x37 κ receptor 6B73 PAR1 3VW7
TM2 61 2.38x38 κ receptor 6B73 US28 4XT1
TM2 62 2.39x39 κ receptor 6B73 AT2 receptor 5UNG
TM2 63 2.40x40 κ receptor 6B73 - -
TM2 64 2.41x41 κ receptor 6B73 κ receptor 6B73
TM2 65 2.42x42 κ receptor 6B73 PAF receptor 5ZKP
TM2 66 2.43x43 κ receptor 6B73 5-HT2B receptor 5TUD
TM2 67 2.44x44 κ receptor 6B73 κ receptor 6B73
TM2 68 2.45x45 κ receptor 6B73 κ receptor 6B73
TM2 69 2.46x46 κ receptor 6B73 κ receptor 6B73
TM2 70 2.47x47 κ receptor 6B73 κ receptor 6B73
TM2 71 2.48x48 κ receptor 6B73 LPA6 receptor 5XSZ
TM2 72 2.49x49 κ receptor 6B73 κ receptor 6B73
TM2 73 2.50x50 κ receptor 6B73 κ receptor 6B73
TM2 74 2.51x51 κ receptor 6B73 P2Y1 receptor 4XNW
TM2 75 2.52x52 κ receptor 6B73 κ receptor 6B73
TM2 76 2.53x53 κ receptor 6B73 AT2 receptor 5UNG
TM2 77 2.54x54 κ receptor 6B73 P2Y12 receptor 4NTJ
TM2 78 2.55x55 κ receptor 6B73 PAF receptor 5ZKP
TM2 79 2.56x56 κ receptor 6B73 OX2 receptor 5WS3
TM2 80 2.57x57 κ receptor 6B73 μ receptor 5C1M
TM2 81 2.58x58 κ receptor 6B73 κ receptor 6B73
TM2 82 2.59x59 κ receptor 6B73 κ receptor 6B73
TM2 83 2.60x60 κ receptor 6B73 P2Y1 receptor 4XNW
TM2 84 2.61x61 κ receptor 6B73 US28 4XT1
TM2 85 2.62x62 κ receptor 6B73 - -
TM2 86 2.63x63 κ receptor 6B73 μ receptor 5C1M
TM2 87 2.64x64 κ receptor 6B73 κ receptor 6B73
TM2 88 2.65x65 κ receptor 6B73 LPA6 receptor 5XSZ
TM2 89 2.66x66 κ receptor 6B73 apelin receptor 5VBL
TM2 90 2.67x67 apelin receptor 5VBL - -
ECL1 91 - - - -
ECL1 92 23.49x49 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
ECL1 93 23.50x50 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
ECL1 94 23.51x51 P2Y1 receptor 4XNW S1P1 receptor 3V2Y
ECL1 95 23.52x52 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM3 96 3.21x21 κ receptor 6B73 κ receptor 6B73
TM3 97 3.22x22 κ receptor 6B73 κ receptor 6B73
TM3 98 3.23x23 κ receptor 6B73 μ receptor 5C1M
TM3 99 3.24x24 κ receptor 6B73 US28 5WB1
TM3 100 3.25x25 κ receptor 6B73 κ receptor 6B73
TM3 101 3.26x26 κ receptor 6B73 NTS1 receptor 5T04
TM3 102 3.27x27 κ receptor 6B73 LPA6 receptor 5XSZ
TM3 103 3.28x28 κ receptor 6B73 - -
TM3 104 3.29x29 κ receptor 6B73 κ receptor 6B73
TM3 105 3.30x30 κ receptor 6B73 5-HT2B receptor 5TUD
TM3 106 3.31x31 κ receptor 6B73 CCR9 5LWE
TM3 107 3.32x32 κ receptor 6B73 AT2 receptor 5UNG
TM3 108 3.33x33 κ receptor 6B73 OX1 receptor 4ZJ8
TM3 109 3.34x34 κ receptor 6B73 CCR9 5LWE
TM3 110 3.35x35 κ receptor 6B73 κ receptor 6B73
TM3 111 3.36x36 κ receptor 6B73 - -
TM3 112 3.37x37 κ receptor 6B73 A1 receptor 6D9H
TM3 113 3.38x38 κ receptor 6B73 LPA6 receptor 5XSZ
TM3 114 3.39x39 κ receptor 6B73 κ receptor 6B73
TM3 115 3.40x40 κ receptor 6B73 κ receptor 6B73
TM3 116 3.41x41 κ receptor 6B73 - -
TM3 117 3.42x42 κ receptor 6B73 LPA6 receptor 5XSZ
TM3 118 3.43x43 κ receptor 6B73 κ receptor 6B73
TM3 119 3.44x44 κ receptor 6B73 κ receptor 6B73
TM3 120 3.45x45 κ receptor 6B73 PAF receptor 5ZKP
TM3 121 3.46x46 κ receptor 6B73 - -
TM3 122 3.47x47 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 123 3.48x48 κ receptor 6B73 κ receptor 6B73
TM3 124 3.49x49 κ receptor 6B73 κ receptor 6B73
TM3 125 3.50x50 κ receptor 6B73 κ receptor 6B73
TM3 126 3.51x51 κ receptor 6B73 κ receptor 6B73
TM3 127 3.52x52 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 128 3.53x53 κ receptor 6B73 A1 receptor 6D9H
TM3 129 3.54x54 κ receptor 6B73 κ receptor 6B73
TM3 130 3.55x55 κ receptor 6B73 LPA6 receptor 5XSZ
TM3 131 3.56x56 κ receptor 6B73 κ receptor 6B73
ICL2 132 34.50x50 - - - -
ICL2 133 34.51x51 P2Y1 receptor 4XNW - -
ICL2 134 34.52x52 P2Y1 receptor 4XNW D3 receptor 3PBL
ICL2 135 34.53x53 P2Y1 receptor 4XNW κ receptor 6B73
ICL2 136 34.54x54 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
ICL2 137 34.55x55 P2Y1 receptor 4XNW C5a1 receptor 6C1R
ICL2 138 34.56x56 P2Y1 receptor 4XNW 5-HT1B receptor 6G79
ICL2 139 34.57x57 - - - -
TM4 140 4.38x38 κ receptor 6B73 NTS1 receptor 5T04
TM4 141 4.39x39 κ receptor 6B73 Y1 receptor 5ZBH
TM4 142 4.40x40 κ receptor 6B73 μ receptor 5C1M
TM4 143 4.41x41 κ receptor 6B73 5-HT2B receptor 5TUD
TM4 144 4.42x42 κ receptor 6B73 κ receptor 6B73
TM4 145 4.43x43 κ receptor 6B73 5-HT1B receptor 6G79
TM4 146 4.44x44 κ receptor 6B73 κ receptor 6B73
TM4 147 4.45x45 κ receptor 6B73 κ receptor 6B73
TM4 148 4.46x46 κ receptor 6B73 US28 4XT1
TM4 149 4.47x47 κ receptor 6B73 CB1 receptor 5XRA
TM4 150 4.48x48 κ receptor 6B73 AT2 receptor 5UNG
TM4 151 4.49x49 κ receptor 6B73 apelin receptor 5VBL
TM4 152 4.50x50 κ receptor 6B73 κ receptor 6B73
TM4 153 4.51x51 κ receptor 6B73 C5a1 receptor 5O9H
TM4 154 4.52x52 κ receptor 6B73 5-HT2B receptor 5TUD
TM4 155 4.53x53 κ receptor 6B73 - -
TM4 156 4.54x54 κ receptor 6B73 5-HT2B receptor 5TUD
TM4 157 4.55x55 κ receptor 6B73 PAF receptor 5ZKP
TM4 158 4.56x56 κ receptor 6B73 NTS1 receptor 5T04
TM4 159 4.57x57 κ receptor 6B73 PAR2 5NDD
TM4 160 4.58x58 κ receptor 6B73 CB1 receptor 5XRA
TM4 161 4.59x59 κ receptor 6B73 - -
TM4 162 4.60x60 κ receptor 6B73 - -
TM4 163 4.61x61 κ receptor 6B73 PAF receptor 5ZKP
TM4 164 4.62x62 κ receptor 6B73 - -
TM4 165 4.63x63 κ receptor 6B73 - -
TM4 166 4.64x64 κ receptor 6B73 5-HT2B receptor 5TUD
ECL2 167 - - - -
ECL2 168 CCR5 5UIW - -
ECL2 169 CCR5 5UIW - -
ECL2 170 CCR5 5UIW - -
ECL2 171 CCR5 5UIW - -
ECL2 172 CCR5 5UIW CCR5 5UIW
ECL2 173 CCR5 5UIW - -
ECL2 174 CCR5 5UIW - -
ECL2 175 CCR5 5UIW - -
ECL2 176 - - - -
ECL2 177 45.50x50 κ receptor 6B73 κ receptor 6B73
ECL2 178 45.51x51 κ receptor 6B73 κ receptor 6B73
ECL2 179 45.52x52 κ receptor 6B73 CCR5 5UIW
TM5 180 5.30x31 κ receptor 4DJH P2Y12 receptor 4NTJ
TM5 181 5.31x32 κ receptor 4DJH δ receptor 4N6H
TM5 182 5.32x33 κ receptor 4DJH - -
TM5 183 5.33x34 κ receptor 6B73 - -
TM5 184 5.34x35 κ receptor 6B73 LPA6 receptor 5XSZ
TM5 185 5.35x36 κ receptor 6B73 - -
TM5 186 5.36x37 κ receptor 6B73 P2Y1 receptor 4XNW
TM5 187 5.37x38 κ receptor 6B73 - -
TM5 188 5.38x39 κ receptor 6B73 - -
TM5 189 5.39x40 κ receptor 6B73 PAF receptor 5ZKP
TM5 190 5.40x41 κ receptor 6B73 - -
TM5 191 5.41x42 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 192 5.42x43 κ receptor 6B73 Rhodopsin 5DYS
TM5 193 5.43x44 κ receptor 6B73 κ receptor 6B73
TM5 194 5.44x45 κ receptor 6B73 5-HT2B receptor 5TUD
TM5 195 5.45x46 κ receptor 6B73 AT2 receptor 5UNG
TM5 196 5.46x461 κ receptor 6B73 - -
TM5 197 5.47x47 κ receptor 6B73 κ receptor 6B73
TM5 198 5.48x48 κ receptor 6B73 PAF receptor 5ZKP
TM5 199 5.49x49 κ receptor 6B73 PAF receptor 5ZKP
TM5 200 5.50x50 κ receptor 6B73 κ receptor 6B73
TM5 201 5.51x51 κ receptor 6B73 LPA6 receptor 5XSZ
TM5 202 5.52x52 κ receptor 6B73 OX1 receptor 4ZJ8
TM5 203 5.53x53 κ receptor 6B73 κ receptor 6B73
TM5 204 5.54x54 κ receptor 6B73 κ receptor 6B73
TM5 205 5.55x55 κ receptor 6B73 PAF receptor 5ZKP
TM5 206 5.56x56 κ receptor 6B73 PAF receptor 5ZKP
TM5 207 5.57x57 κ receptor 6B73 κ receptor 6B73
TM5 208 5.58x58 κ receptor 6B73 LPA6 receptor 5XSZ
TM5 209 5.59x59 κ receptor 6B73 LPA6 receptor 5XSZ
TM5 210 5.60x60 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 211 5.61x61 κ receptor 6B73 AT2 receptor 5UNG
TM5 212 5.62x62 κ receptor 6B73 κ receptor 6B73
TM5 213 5.63x63 κ receptor 6B73 CB1 receptor 5XRA
TM5 214 5.64x64 κ receptor 6B73 - -
TM5 215 5.65x65 κ receptor 6B73 κ receptor 6B73
TM5 216 5.66x66 κ receptor 6B73 5-HT1B receptor 6G79
TM5 217 5.67x67 κ receptor 6B73 - -
ICL3 218 - - - -
ICL3 219 - - - -
ICL3 220 - - - -
ICL3 221 - - - -
TM6 222 6.26x26 κ receptor 6B73 NTS1 receptor 5T04
TM6 223 6.27x27 κ receptor 6B73 - -
TM6 224 6.28x28 κ receptor 6B73 PAF receptor 5ZKP
TM6 225 6.29x29 κ receptor 6B73 β2-adrenoceptor 4LDE
TM6 226 6.30x30 κ receptor 6B73 - -
TM6 227 6.31x31 κ receptor 6B73 PAF receptor 5ZKP
TM6 228 6.32x32 κ receptor 6B73 μ receptor 5C1M
TM6 229 6.33x33 κ receptor 6B73 5-HT2B receptor 5TUD
TM6 230 6.34x34 κ receptor 6B73 - -
TM6 231 6.35x35 κ receptor 6B73 - -
TM6 232 6.36x36 κ receptor 6B73 PAR1 3VW7
TM6 233 6.37x37 κ receptor 6B73 LPA6 receptor 5XSZ
TM6 234 6.38x38 κ receptor 6B73 AT1 receptor 4ZUD
TM6 235 6.39x39 κ receptor 6B73 κ receptor 6B73
TM6 236 6.40x40 κ receptor 6B73 κ receptor 6B73
TM6 237 6.41x41 κ receptor 6B73 D2 receptor 6CM4
TM6 238 6.42x42 κ receptor 6B73 NTS1 receptor 5T04
TM6 239 6.43x43 κ receptor 6B73 κ receptor 6B73
TM6 240 6.44x44 κ receptor 6B73 κ receptor 6B73
TM6 241 6.45x45 κ receptor 6B73 κ receptor 6B73
TM6 242 6.46x46 κ receptor 6B73 AT2 receptor 5UNG
TM6 243 6.47x47 κ receptor 6B73 κ receptor 6B73
TM6 244 6.48x48 κ receptor 6B73 LPA6 receptor 5XSZ
TM6 245 6.49x49 κ receptor 6B73 AT2 receptor 5UNG
TM6 246 6.50x50 κ receptor 6B73 κ receptor 6B73
TM6 247 6.51x51 κ receptor 6B73 PAR2 5NDD
TM6 248 6.52x52 κ receptor 6B73 - -
TM6 249 6.53x53 κ receptor 6B73 LPA6 receptor 5XSZ
TM6 250 6.54x54 κ receptor 6B73 PAF receptor 5ZKP
TM6 251 6.55x55 κ receptor 6B73 NTS1 receptor 5T04
TM6 252 6.56x56 κ receptor 6B73 μ receptor 5C1M
TM6 253 6.57x57 κ receptor 6B73 - -
TM6 254 6.58x58 κ receptor 6B73 Rhodopsin 5DYS
TM6 255 6.59x59 κ receptor 6B73 Rhodopsin 5DYS
TM6 256 6.60x60 κ receptor 6B73 Y1 receptor 5ZBH
TM6 257 6.61x61 κ receptor 6B73 C5a1 receptor 5O9H
TM6 258 6.62x62 P2Y1 receptor 4XNW US28 4XT1
TM6 259 6.63x63 P2Y1 receptor 4XNW - -
TM6 260 6.64x64 P2Y1 receptor 4XNW - -
ECL3 261 - - - -
ECL3 262 κ receptor 6B73 - -
ECL3 263 κ receptor 6B73 - -
ECL3 264 κ receptor 6B73 - -
TM7 265 7.24x23 P2Y1 receptor 4XNW - -
TM7 266 7.25x24 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM7 267 7.26x25 P2Y1 receptor 4XNW AT2 receptor 5UNG
TM7 268 7.27x26 P2Y1 receptor 4XNW AT2 receptor 5UNG
TM7 269 7.28x27 κ receptor 6B73 - -
TM7 270 7.29x28 κ receptor 6B73 US28 4XT1
TM7 271 7.30x29 κ receptor 6B73 US28 4XT1
TM7 272 7.31x30 κ receptor 6B73 LPA6 receptor 5XSZ
TM7 273 7.32x31 κ receptor 6B73 AT2 receptor 5UNG
TM7 274 7.33x32 κ receptor 6B73 AT2 receptor 5UNG
TM7 275 7.34x33 κ receptor 6B73 AT2 receptor 5UNG
TM7 276 7.35x34 κ receptor 6B73 5-HT1B receptor 6G79
TM7 277 7.36x35 κ receptor 6B73 - -
TM7 278 7.37x36 κ receptor 6B73 LPA6 receptor 5XSZ
TM7 279 7.38x37 κ receptor 6B73 PAF receptor 5ZKP
TM7 280 7.39x38 κ receptor 6B73 LPA6 receptor 5XSZ
TM7 281 7.40x39 κ receptor 6B73 US28 4XT1
TM7 282 7.41x40 κ receptor 6B73 Rhodopsin 5DYS
TM7 283 7.42x41 κ receptor 6B73 A1 receptor 6D9H
TM7 284 7.43x42 κ receptor 6B73 κ receptor 6B73
TM7 285 7.44x43 κ receptor 6B73 - -
TM7 286 7.45x45 κ receptor 6B73 κ receptor 6B73
TM7 287 7.46x46 κ receptor 6B73 κ receptor 6B73
TM7 288 7.47x47 κ receptor 6B73 - -
TM7 289 7.48x48 κ receptor 6B73 κ receptor 6B73
TM7 290 7.49x49 κ receptor 6B73 LPA6 receptor 5XSZ
TM7 291 7.50x50 κ receptor 6B73 κ receptor 6B73
TM7 292 7.51x51 κ receptor 6B73 μ receptor 6DDF
TM7 293 7.52x52 κ receptor 4DJH LPA6 receptor 5XSZ
TM7 294 7.53x53 κ receptor 4DJH κ receptor 4DJH
TM7 295 7.54x54 κ receptor 4DJH LPA6 receptor 5XSZ
TM7 296 7.55x55 κ receptor 4DJH κ receptor 4DJH
TM7 297 7.56x56 κ receptor 4DJH 5-HT1B receptor 6G79
H8 298 8.47x47 κ receptor 4DJH β2-adrenoceptor 3SN6
H8 299 8.48x48 κ receptor 4DJH β2-adrenoceptor 3SN6
H8 300 8.49x49 κ receptor 4DJH P2Y12 receptor 4NTJ
H8 301 8.50x50 κ receptor 4DJH κ receptor 4DJH
H8 302 8.51x51 κ receptor 4DJH - -
H8 303 8.52x52 κ receptor 4DJH Rhodopsin 5DYS
H8 304 8.53x53 κ receptor 4DJH - -
H8 305 8.54x54 κ receptor 4DJH κ receptor 4DJH
H8 306 8.55x55 κ receptor 4DJH 5-HT2C receptor 6BQG
H8 307 8.56x56 κ receptor 4DJH Rhodopsin 5DYS
H8 308 8.57x57 κ receptor 4DJH β2-adrenoceptor 3SN6
H8 309 8.58x58 κ receptor 4DJH 5-HT2B receptor 5TUD
H8 310 8.59x59 κ receptor 4DJH - -
C-term 311 - - - -
C-term 312 - - - -
C-term 313 - - - -
C-term 314 - - - -
C-term 315 - - - -