HCA2 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive (Δ distance (Å): -1.28 docs)

VERSION

2018-07-10

MAIN TEMPLATE

κ receptor (sequence similarity: 47%) PDB: 4DJH

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 82.8 11.1 6.1
Side-chains 22.6 53.7 23.6

Number of backbone templates: 6
Number of rotamer templates: 43

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4DJH
6B73
5VBL
4XNW
5UIW
3ODU
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 20 - - - -
N-term 21 - - - -
N-term 22 - - - -
N-term 23 κ receptor 4DJH κ receptor 4DJH
N-term 24 κ receptor 4DJH κ receptor 4DJH
TM1 25 1.30x30 κ receptor 4DJH CXCR4 3ODU
TM1 26 1.31x31 κ receptor 4DJH κ receptor 4DJH
TM1 27 1.32x32 κ receptor 4DJH β2-adrenoceptor 5JQH
TM1 28 1.33x33 κ receptor 4DJH LPA1 receptor 4Z35
TM1 29 1.34x34 κ receptor 4DJH OX2 receptor 5WS3
TM1 30 1.35x35 κ receptor 4DJH CCR2 5T1A
TM1 31 1.36x36 κ receptor 4DJH CCR2 5T1A
TM1 32 1.37x37 κ receptor 4DJH CCR2 5T1A
TM1 33 1.38x38 κ receptor 4DJH κ receptor 4DJH
TM1 34 1.39x39 κ receptor 4DJH D2 receptor 6CM4
TM1 35 1.40x40 κ receptor 4DJH Y1 receptor 5ZBH
TM1 36 1.41x41 κ receptor 4DJH CCR2 5T1A
TM1 37 1.42x42 κ receptor 4DJH - -
TM1 38 1.43x43 κ receptor 4DJH κ receptor 4DJH
TM1 39 1.44x44 κ receptor 4DJH CCR2 5T1A
TM1 40 1.45x45 κ receptor 4DJH CCR2 5T1A
TM1 41 1.46x46 κ receptor 4DJH κ receptor 4DJH
TM1 42 1.47x47 κ receptor 4DJH κ receptor 4DJH
TM1 43 1.48x48 κ receptor 4DJH δ receptor 4N6H
TM1 44 1.49x49 κ receptor 4DJH κ receptor 4DJH
TM1 45 1.50x50 κ receptor 4DJH κ receptor 4DJH
TM1 46 1.51x51 κ receptor 4DJH apelin receptor 5VBL
TM1 47 1.52x52 κ receptor 4DJH κ receptor 4DJH
TM1 48 1.53x53 κ receptor 4DJH P2Y1 receptor 4XNW
TM1 49 1.54x54 κ receptor 4DJH apelin receptor 5VBL
TM1 50 1.55x55 κ receptor 4DJH apelin receptor 5VBL
TM1 51 1.56x56 κ receptor 4DJH CCR2 5T1A
TM1 52 1.57x57 κ receptor 4DJH M3 receptor 4U15
TM1 53 1.58x58 κ receptor 4DJH AT2 receptor 5UNG
TM1 54 1.59x59 κ receptor 4DJH AT1 receptor 4ZUD
TM1 55 1.60x60 κ receptor 4DJH Rhodopsin 1GZM
ICL1 56 κ receptor 4DJH - -
ICL1 57 κ receptor 4DJH - -
ICL1 58 κ receptor 4DJH - -
ICL1 59 κ receptor 4DJH - -
TM2 60 2.37x37 κ receptor 4DJH PAR1 3VW7
TM2 61 2.38x38 κ receptor 4DJH apelin receptor 5VBL
TM2 62 2.39x39 κ receptor 4DJH CB1 receptor 5TGZ
TM2 63 2.40x40 κ receptor 4DJH - -
TM2 64 2.41x41 κ receptor 4DJH κ receptor 4DJH
TM2 65 2.42x42 κ receptor 4DJH apelin receptor 5VBL
TM2 66 2.43x43 κ receptor 4DJH CCR2 5T1A
TM2 67 2.44x44 κ receptor 4DJH κ receptor 4DJH
TM2 68 2.45x45 κ receptor 4DJH κ receptor 4DJH
TM2 69 2.46x46 κ receptor 4DJH κ receptor 4DJH
TM2 70 2.47x47 κ receptor 4DJH κ receptor 4DJH
TM2 71 2.48x48 κ receptor 4DJH apelin receptor 5VBL
TM2 72 2.49x49 κ receptor 4DJH κ receptor 4DJH
TM2 73 2.50x50 κ receptor 4DJH κ receptor 4DJH
TM2 74 2.51x51 κ receptor 4DJH C5a1 receptor 5O9H
TM2 75 2.52x52 κ receptor 4DJH κ receptor 4DJH
TM2 76 2.53x53 κ receptor 4DJH D4 receptor 5WIV
TM2 77 2.54x54 κ receptor 4DJH ETB receptor 5X93
TM2 78 2.55x55 κ receptor 4DJH CCR2 5T1A
TM2 79 2.56x56 κ receptor 4DJH OX2 receptor 5WS3
TM2 80 2.57x57 κ receptor 4DJH μ receptor 4DKL
TM2 81 2.58x58 κ receptor 4DJH κ receptor 4DJH
TM2 82 2.59x59 κ receptor 4DJH κ receptor 4DJH
TM2 83 2.60x60 κ receptor 4DJH C5a1 receptor 5O9H
TM2 84 2.61x61 κ receptor 4DJH LPA1 receptor 4Z35
TM2 85 2.62x62 κ receptor 4DJH - -
TM2 86 2.63x63 κ receptor 4DJH μ receptor 4DKL
TM2 87 2.64x64 κ receptor 4DJH κ receptor 4DJH
TM2 88 2.65x65 κ receptor 4DJH CXCR4 3ODU
TM2 89 2.66x66 κ receptor 4DJH apelin receptor 5VBL
TM2 90 2.67x67 apelin receptor 5VBL - -
ECL1 91 - - - -
ECL1 92 23.49x49 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
ECL1 93 23.50x50 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
ECL1 94 23.51x51 P2Y1 receptor 4XNW S1P1 receptor 3V2Y
ECL1 95 23.52x52 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM3 96 3.21x21 κ receptor 4DJH κ receptor 4DJH
TM3 97 3.22x22 κ receptor 4DJH κ receptor 4DJH
TM3 98 3.23x23 κ receptor 4DJH μ receptor 4DKL
TM3 99 3.24x24 κ receptor 4DJH US28 5WB1
TM3 100 3.25x25 κ receptor 4DJH κ receptor 4DJH
TM3 101 3.26x26 κ receptor 4DJH NTS1 receptor 4BUO
TM3 102 3.27x27 κ receptor 4DJH CCR2 5T1A
TM3 103 3.28x28 κ receptor 4DJH - -
TM3 104 3.29x29 κ receptor 4DJH κ receptor 4DJH
TM3 105 3.30x30 κ receptor 4DJH Y1 receptor 5ZBH
TM3 106 3.31x31 κ receptor 4DJH CCR9 5LWE
TM3 107 3.32x32 κ receptor 4DJH AT2 receptor 5UNG
TM3 108 3.33x33 κ receptor 4DJH OX1 receptor 4ZJ8
TM3 109 3.34x34 κ receptor 4DJH CCR9 5LWE
TM3 110 3.35x35 κ receptor 4DJH κ receptor 4DJH
TM3 111 3.36x36 κ receptor 4DJH - -
TM3 112 3.37x37 κ receptor 4DJH M1 receptor 5CXV
TM3 113 3.38x38 κ receptor 4DJH CCR2 5T1A
TM3 114 3.39x39 κ receptor 4DJH κ receptor 4DJH
TM3 115 3.40x40 κ receptor 4DJH κ receptor 4DJH
TM3 116 3.41x41 κ receptor 4DJH - -
TM3 117 3.42x42 κ receptor 4DJH CCR2 5T1A
TM3 118 3.43x43 κ receptor 4DJH κ receptor 4DJH
TM3 119 3.44x44 κ receptor 4DJH κ receptor 4DJH
TM3 120 3.45x45 κ receptor 4DJH β2-adrenoceptor 5JQH
TM3 121 3.46x46 κ receptor 4DJH - -
TM3 122 3.47x47 κ receptor 4DJH OX2 receptor 5WS3
TM3 123 3.48x48 κ receptor 4DJH κ receptor 4DJH
TM3 124 3.49x49 κ receptor 4DJH κ receptor 4DJH
TM3 125 3.50x50 κ receptor 4DJH κ receptor 4DJH
TM3 126 3.51x51 κ receptor 4DJH κ receptor 4DJH
TM3 127 3.52x52 κ receptor 4DJH β2-adrenoceptor 5JQH
TM3 128 3.53x53 κ receptor 4DJH A1 receptor 5UEN
TM3 129 3.54x54 κ receptor 4DJH κ receptor 4DJH
TM3 130 3.55x55 κ receptor 4DJH CCR2 5T1A
TM3 131 3.56x56 κ receptor 4DJH κ receptor 4DJH
ICL2 132 34.50x50 - - - -
ICL2 133 34.51x51 P2Y1 receptor 4XNW - -
ICL2 134 34.52x52 P2Y1 receptor 4XNW D3 receptor 3PBL
ICL2 135 34.53x53 P2Y1 receptor 4XNW μ receptor 4DKL
ICL2 136 34.54x54 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
ICL2 137 34.55x55 P2Y1 receptor 4XNW C5a1 receptor 6C1R
ICL2 138 34.56x56 P2Y1 receptor 4XNW M3 receptor 4U15
ICL2 139 34.57x57 - - - -
TM4 140 4.38x38 κ receptor 4DJH D2 receptor 6CM4
TM4 141 4.39x39 κ receptor 4DJH Y1 receptor 5ZBH
TM4 142 4.40x40 κ receptor 4DJH μ receptor 4DKL
TM4 143 4.41x41 κ receptor 4DJH 5-HT2B receptor 4IB4
TM4 144 4.42x42 κ receptor 4DJH κ receptor 4DJH
TM4 145 4.43x43 κ receptor 4DJH apelin receptor 5VBL
TM4 146 4.44x44 κ receptor 4DJH κ receptor 4DJH
TM4 147 4.45x45 κ receptor 4DJH κ receptor 4DJH
TM4 148 4.46x46 κ receptor 4DJH CCR2 5T1A
TM4 149 4.47x47 κ receptor 4DJH CB1 receptor 5TGZ
TM4 150 4.48x48 κ receptor 4DJH ETB receptor 5X93
TM4 151 4.49x49 κ receptor 4DJH apelin receptor 5VBL
TM4 152 4.50x50 κ receptor 4DJH κ receptor 4DJH
TM4 153 4.51x51 κ receptor 4DJH C5a1 receptor 5O9H
TM4 154 4.52x52 κ receptor 4DJH 5-HT2C receptor 6BQH
TM4 155 4.53x53 κ receptor 4DJH - -
TM4 156 4.54x54 κ receptor 4DJH 5-HT2C receptor 6BQH
TM4 157 4.55x55 κ receptor 4DJH δ receptor 4N6H
TM4 158 4.56x56 κ receptor 4DJH apelin receptor 5VBL
TM4 159 4.57x57 κ receptor 4DJH CXCR4 3ODU
TM4 160 4.58x58 κ receptor 4DJH δ receptor 4N6H
TM4 161 4.59x59 κ receptor 4DJH - -
TM4 162 4.60x60 κ receptor 4DJH - -
TM4 163 4.61x61 κ receptor 4DJH D2 receptor 6CM4
TM4 164 4.62x62 κ receptor 4DJH - -
TM4 165 4.63x63 κ receptor 4DJH - -
TM4 166 4.64x64 κ receptor 4DJH PAR1 3VW7
ECL2 167 - - - -
ECL2 168 CCR5 5UIW - -
ECL2 169 CCR5 5UIW - -
ECL2 170 CCR5 5UIW - -
ECL2 171 CCR5 5UIW - -
ECL2 172 CCR5 5UIW CCR5 5UIW
ECL2 173 CCR5 5UIW - -
ECL2 174 CCR5 5UIW - -
ECL2 175 CCR5 5UIW - -
ECL2 176 - - - -
ECL2 177 45.50x50 κ receptor 4DJH κ receptor 4DJH
ECL2 178 45.51x51 κ receptor 4DJH κ receptor 4DJH
ECL2 179 45.52x52 κ receptor 4DJH CCR5 5UIW
TM5 180 5.30x31 κ receptor 4DJH ETB receptor 5X93
TM5 181 5.31x32 κ receptor 4DJH δ receptor 4N6H
TM5 182 5.32x33 κ receptor 4DJH - -
TM5 183 5.33x34 κ receptor 4DJH - -
TM5 184 5.34x35 κ receptor 4DJH Y1 receptor 5ZBH
TM5 185 5.35x36 κ receptor 4DJH - -
TM5 186 5.36x37 κ receptor 4DJH P2Y1 receptor 4XNW
TM5 187 5.37x38 κ receptor 4DJH - -
TM5 188 5.38x39 κ receptor 4DJH - -
TM5 189 5.39x40 κ receptor 4DJH OX2 receptor 5WS3
TM5 190 5.40x41 κ receptor 4DJH - -
TM5 191 5.41x42 κ receptor 4DJH β2-adrenoceptor 5JQH
TM5 192 5.42x43 κ receptor 4DJH Rhodopsin 1GZM
TM5 193 5.43x44 κ receptor 4DJH κ receptor 4DJH
TM5 194 5.44x45 κ receptor 4DJH δ receptor 4N6H
TM5 195 5.45x46 κ receptor 4DJH CCR2 5T1A
TM5 196 5.46x461 κ receptor 4DJH - -
TM5 197 5.47x47 κ receptor 4DJH κ receptor 4DJH
TM5 198 5.48x48 κ receptor 4DJH Y1 receptor 5ZBH
TM5 199 5.49x49 κ receptor 4DJH CCR2 5T1A
TM5 200 5.50x50 κ receptor 4DJH κ receptor 4DJH
TM5 201 5.51x51 κ receptor 4DJH CCR2 5T1A
TM5 202 5.52x52 κ receptor 4DJH OX1 receptor 4ZJ8
TM5 203 5.53x53 κ receptor 4DJH κ receptor 4DJH
TM5 204 5.54x54 κ receptor 4DJH κ receptor 4DJH
TM5 205 5.55x55 κ receptor 4DJH apelin receptor 5VBL
TM5 206 5.56x56 κ receptor 4DJH β2-adrenoceptor 5JQH
TM5 207 5.57x57 κ receptor 4DJH κ receptor 4DJH
TM5 208 5.58x58 κ receptor 4DJH LPA6 receptor 5XSZ
TM5 209 5.59x59 κ receptor 4DJH BLT1 receptor 5X33
TM5 210 5.60x60 κ receptor 4DJH β2-adrenoceptor 5JQH
TM5 211 5.61x61 κ receptor 4DJH CCR2 5T1A
TM5 212 5.62x62 κ receptor 4DJH κ receptor 4DJH
TM5 213 5.63x63 κ receptor 4DJH CB1 receptor 5TGZ
TM5 214 5.64x64 κ receptor 4DJH - -
TM5 215 5.65x65 κ receptor 4DJH κ receptor 4DJH
TM5 216 5.66x66 κ receptor 4DJH δ receptor 4N6H
TM5 217 5.67x67 κ receptor 4DJH - -
ICL3 218 - - - -
ICL3 219 - - - -
ICL3 220 - - - -
ICL3 221 - - - -
TM6 222 6.26x26 κ receptor 6B73 NTS1 receptor 4BUO
TM6 223 6.27x27 κ receptor 6B73 - -
TM6 224 6.28x28 κ receptor 4DJH PAF receptor 5ZKP
TM6 225 6.29x29 κ receptor 4DJH β2-adrenoceptor 2RH1
TM6 226 6.30x30 κ receptor 4DJH - -
TM6 227 6.31x31 κ receptor 4DJH Y1 receptor 5ZBH
TM6 228 6.32x32 κ receptor 4DJH μ receptor 4DKL
TM6 229 6.33x33 κ receptor 4DJH CCR2 5T1A
TM6 230 6.34x34 κ receptor 4DJH - -
TM6 231 6.35x35 κ receptor 4DJH - -
TM6 232 6.36x36 κ receptor 4DJH PAR1 3VW7
TM6 233 6.37x37 κ receptor 4DJH CCR2 5T1A
TM6 234 6.38x38 κ receptor 4DJH AT1 receptor 4ZUD
TM6 235 6.39x39 κ receptor 4DJH κ receptor 4DJH
TM6 236 6.40x40 κ receptor 4DJH κ receptor 4DJH
TM6 237 6.41x41 κ receptor 4DJH D2 receptor 6CM4
TM6 238 6.42x42 κ receptor 4DJH CCR2 5T1A
TM6 239 6.43x43 κ receptor 4DJH κ receptor 4DJH
TM6 240 6.44x44 κ receptor 4DJH κ receptor 4DJH
TM6 241 6.45x45 κ receptor 4DJH κ receptor 4DJH
TM6 242 6.46x46 κ receptor 4DJH OX2 receptor 5WS3
TM6 243 6.47x47 κ receptor 4DJH κ receptor 4DJH
TM6 244 6.48x48 κ receptor 4DJH PAR2 5NDD
TM6 245 6.49x49 κ receptor 4DJH CXCR4 3ODU
TM6 246 6.50x50 κ receptor 4DJH κ receptor 4DJH
TM6 247 6.51x51 κ receptor 4DJH PAR2 5NDD
TM6 248 6.52x52 κ receptor 4DJH - -
TM6 249 6.53x53 κ receptor 4DJH NOP receptor 5DHG
TM6 250 6.54x54 κ receptor 4DJH CCR2 5T1A
TM6 251 6.55x55 κ receptor 4DJH ETB receptor 5X93
TM6 252 6.56x56 κ receptor 4DJH μ receptor 4DKL
TM6 253 6.57x57 κ receptor 4DJH - -
TM6 254 6.58x58 κ receptor 4DJH Rhodopsin 1GZM
TM6 255 6.59x59 κ receptor 4DJH Rhodopsin 1GZM
TM6 256 6.60x60 κ receptor 4DJH Y1 receptor 5ZBH
TM6 257 6.61x61 κ receptor 4DJH C5a1 receptor 5O9H
TM6 258 6.62x62 P2Y1 receptor 4XNW CXCR4 3ODU
TM6 259 6.63x63 P2Y1 receptor 4XNW - -
TM6 260 6.64x64 P2Y1 receptor 4XNW - -
ECL3 261 - - - -
ECL3 262 CXCR4 3ODU - -
ECL3 263 CXCR4 3ODU - -
ECL3 264 - - - -
TM7 265 7.24x23 P2Y1 receptor 4XNW - -
TM7 266 7.25x24 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM7 267 7.26x25 P2Y1 receptor 4XNW CXCR4 3ODU
TM7 268 7.27x26 P2Y1 receptor 4XNW CCR9 5LWE
TM7 269 7.28x27 P2Y1 receptor 4XNW - -
TM7 270 7.29x28 P2Y1 receptor 4XNW US28 4XT1
TM7 271 7.30x29 P2Y1 receptor 4XNW US28 4XT1
TM7 272 7.31x30 κ receptor 4DJH δ receptor 4N6H
TM7 273 7.32x31 κ receptor 4DJH CCR2 5T1A
TM7 274 7.33x32 κ receptor 4DJH Y1 receptor 5ZBH
TM7 275 7.34x33 κ receptor 4DJH δ receptor 4N6H
TM7 276 7.35x34 κ receptor 4DJH apelin receptor 5VBL
TM7 277 7.36x35 κ receptor 4DJH - -
TM7 278 7.37x36 κ receptor 4DJH CXCR4 3ODU
TM7 279 7.38x37 κ receptor 4DJH CCR2 5T1A
TM7 280 7.39x38 κ receptor 4DJH LPA1 receptor 4Z35
TM7 281 7.40x39 κ receptor 4DJH C5a1 receptor 5O9H
TM7 282 7.41x40 κ receptor 4DJH C5a1 receptor 5O9H
TM7 283 7.42x41 κ receptor 4DJH A1 receptor 5UEN
TM7 284 7.43x42 κ receptor 4DJH κ receptor 4DJH
TM7 285 7.44x43 κ receptor 4DJH - -
TM7 286 7.45x45 κ receptor 4DJH κ receptor 4DJH
TM7 287 7.46x46 κ receptor 4DJH κ receptor 4DJH
TM7 288 7.47x47 κ receptor 4DJH - -
TM7 289 7.48x48 κ receptor 4DJH κ receptor 4DJH
TM7 290 7.49x49 κ receptor 4DJH PAR2 5NDD
TM7 291 7.50x50 κ receptor 4DJH κ receptor 4DJH
TM7 292 7.51x51 κ receptor 4DJH μ receptor 4DKL
TM7 293 7.52x52 κ receptor 4DJH 5-HT2C receptor 6BQH
TM7 294 7.53x53 κ receptor 4DJH κ receptor 4DJH
TM7 295 7.54x54 κ receptor 4DJH ETB receptor 5X93
TM7 296 7.55x55 κ receptor 4DJH κ receptor 4DJH
TM7 297 7.56x56 κ receptor 4DJH 5-HT1B receptor 4IAQ
H8 298 8.47x47 κ receptor 4DJH OX2 receptor 5WS3
H8 299 8.48x48 κ receptor 4DJH apelin receptor 5VBL
H8 300 8.49x49 κ receptor 4DJH P2Y12 receptor 4NTJ
H8 301 8.50x50 κ receptor 4DJH κ receptor 4DJH
H8 302 8.51x51 κ receptor 4DJH - -
H8 303 8.52x52 κ receptor 4DJH CCR5 5UIW
H8 304 8.53x53 κ receptor 4DJH - -
H8 305 8.54x54 κ receptor 4DJH κ receptor 4DJH
H8 306 8.55x55 κ receptor 4DJH CCR2 5T1A
H8 307 8.56x56 κ receptor 4DJH Rhodopsin 1GZM
H8 308 8.57x57 κ receptor 4DJH δ receptor 4N6H
H8 309 8.58x58 κ receptor 4DJH A2A receptor 3VG9
H8 310 8.59x59 κ receptor 4DJH - -
C-term 311 κ receptor 4DJH κ receptor 4DJH
C-term 312 - - - -
C-term 313 - - - -
C-term 314 - - - -
C-term 315 - - - -