H3 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 8.8 docs)

VERSION

2018-07-10

MAIN TEMPLATE

M2 receptor (sequence similarity: 53%) PDB: 4MQT

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 76.5 13.6 9.9
Side-chains 24.8 48.3 26.8

Number of backbone templates: 8
Number of rotamer templates: 35

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4MQT
3RZE
3PBL
6CM4
5X93
3SN6
5TVN
5WIV
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 31 - - - -
N-term 32 - - - -
N-term 33 - - - -
N-term 34 - - - -
N-term 35 - - - -
TM1 36 1.34x34 M2 receptor 4MQT A2A receptor 5G53
TM1 37 1.35x35 M2 receptor 4MQT 5-HT1B receptor 6G79
TM1 38 1.36x36 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM1 39 1.37x37 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM1 40 1.38x38 M2 receptor 4MQT 5-HT1B receptor 6G79
TM1 41 1.39x39 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM1 42 1.40x40 M2 receptor 4MQT 5-HT1B receptor 6G79
TM1 43 1.41x41 M2 receptor 4MQT 5-HT1B receptor 6G79
TM1 44 1.42x42 M2 receptor 4MQT M2 receptor 4MQT
TM1 45 1.43x43 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM1 46 1.44x44 M2 receptor 4MQT κ receptor 6B73
TM1 47 1.45x45 M2 receptor 4MQT 5-HT1B receptor 6G79
TM1 48 1.46x46 M2 receptor 4MQT M2 receptor 4MQT
TM1 49 1.47x47 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM1 50 1.48x48 M2 receptor 4MQT A2A receptor 5G53
TM1 51 1.49x49 M2 receptor 4MQT M2 receptor 4MQT
TM1 52 1.50x50 M2 receptor 4MQT M2 receptor 4MQT
TM1 53 1.51x51 M2 receptor 4MQT 5-HT1B receptor 6G79
TM1 54 1.52x52 M2 receptor 4MQT M2 receptor 4MQT
TM1 55 1.53x53 M2 receptor 4MQT M2 receptor 4MQT
TM1 56 1.54x54 M2 receptor 4MQT M2 receptor 4MQT
TM1 57 1.55x55 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM1 58 1.56x56 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM1 59 1.57x57 M2 receptor 4MQT AT2 receptor 5UNG
TM1 60 1.58x58 M2 receptor 4MQT μ receptor 5C1M
TM1 61 1.59x59 M2 receptor 4MQT FFA1 receptor 5TZY
TM1 62 1.60x60 M2 receptor 4MQT - -
ICL1 63 12.48x48 - - - -
ICL1 64 12.49x49 H1 receptor 3RZE CB1 receptor 5TGZ
ICL1 65 12.50x50 H1 receptor 3RZE H1 receptor 3RZE
ICL1 66 12.51x51 - - - -
TM2 67 2.37x37 M2 receptor 4MQT M2 receptor 4MQT
TM2 68 2.38x38 M2 receptor 4MQT - -
TM2 69 2.39x39 M2 receptor 4MQT M2 receptor 4MQT
TM2 70 2.40x40 M2 receptor 4MQT M2 receptor 4MQT
TM2 71 2.41x41 M2 receptor 4MQT - -
TM2 72 2.42x42 M2 receptor 4MQT M2 receptor 4MQT
TM2 73 2.43x43 M2 receptor 4MQT M2 receptor 4MQT
TM2 74 2.44x44 M2 receptor 4MQT Rhodopsin 5DYS
TM2 75 2.45x45 M2 receptor 4MQT κ receptor 6B73
TM2 76 2.46x46 M2 receptor 4MQT M2 receptor 4MQT
TM2 77 2.47x47 M2 receptor 4MQT M2 receptor 4MQT
TM2 78 2.48x48 M2 receptor 4MQT 5-HT2C receptor 6BQG
TM2 79 2.49x49 M2 receptor 4MQT NTS1 receptor 5T04
TM2 80 2.50x50 M2 receptor 4MQT M2 receptor 4MQT
TM2 81 2.51x51 M2 receptor 4MQT LPA1 receptor 4Z35
TM2 82 2.52x52 M2 receptor 4MQT 5-HT1B receptor 6G79
TM2 83 2.53x53 M2 receptor 4MQT 5-HT1B receptor 6G79
TM2 84 2.54x54 M2 receptor 4MQT M2 receptor 4MQT
TM2 85 2.55x55 M2 receptor 4MQT A1 receptor 6D9H
TM2 86 2.56x551 M2 receptor 4MQT M2 receptor 4MQT
TM2 87 2.57x56 M2 receptor 4MQT OX2 receptor 5WS3
TM2 88 2.58x57 M2 receptor 4MQT A1 receptor 6D9H
TM2 89 2.59x58 M2 receptor 4MQT 5-HT1B receptor 6G79
TM2 90 2.60x59 M2 receptor 4MQT M2 receptor 4MQT
TM2 91 2.61x60 M2 receptor 4MQT M2 receptor 4MQT
TM2 92 2.62x61 M2 receptor 4MQT LPA6 receptor 5XSZ
TM2 93 2.63x62 M2 receptor 4MQT - -
TM2 94 2.64x63 M2 receptor 4MQT M2 receptor 4MQT
TM2 95 2.65x64 M2 receptor 4MQT - -
TM2 96 2.66x65 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM2 97 2.67x66 M2 receptor 4MQT 5-HT1B receptor 6G79
ECL1 98 - - - -
ECL1 99 23.49x49 H1 receptor 3RZE 5-HT1B receptor 5V54
ECL1 100 23.50x50 H1 receptor 3RZE H1 receptor 3RZE
ECL1 101 23.51x51 H1 receptor 3RZE β2-adrenoceptor 3SN6
ECL1 102 23.52x52 - - - -
TM3 103 3.21x21 M2 receptor 4MQT M2 receptor 4MQT
TM3 104 3.22x22 M2 receptor 4MQT 5-HT2C receptor 6BQG
TM3 105 3.23x23 M2 receptor 4MQT - -
TM3 106 3.24x24 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM3 107 3.25x25 M2 receptor 4MQT M2 receptor 4MQT
TM3 108 3.26x26 M2 receptor 4MQT κ receptor 6B73
TM3 109 3.27x27 M2 receptor 4MQT M2 receptor 4MQT
TM3 110 3.28x28 M2 receptor 4MQT M2 receptor 4MQT
TM3 111 3.29x29 M2 receptor 4MQT M2 receptor 4MQT
TM3 112 3.30x30 M2 receptor 4MQT CXCR4 3ODU
TM3 113 3.31x31 M2 receptor 4MQT Y1 receptor 5ZBH
TM3 114 3.32x32 M2 receptor 4MQT M2 receptor 4MQT
TM3 115 3.33x33 M2 receptor 4MQT M2 receptor 4MQT
TM3 116 3.34x34 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM3 117 3.35x35 M2 receptor 4MQT A1 receptor 6D9H
TM3 118 3.36x36 M2 receptor 4MQT 5-HT1B receptor 6G79
TM3 119 3.37x37 M2 receptor 4MQT 5-HT1B receptor 6G79
TM3 120 3.38x38 M2 receptor 4MQT A1 receptor 6D9H
TM3 121 3.39x39 M2 receptor 4MQT M2 receptor 4MQT
TM3 122 3.40x40 M2 receptor 4MQT NTS1 receptor 5T04
TM3 123 3.41x41 M2 receptor 4MQT κ receptor 6B73
TM3 124 3.42x42 M2 receptor 4MQT M2 receptor 4MQT
TM3 125 3.43x43 M2 receptor 4MQT AT2 receptor 5UNG
TM3 126 3.44x44 M2 receptor 4MQT Rhodopsin 5DYS
TM3 127 3.45x45 M2 receptor 4MQT CB1 receptor 5XRA
TM3 128 3.46x46 M2 receptor 4MQT M2 receptor 4MQT
TM3 129 3.47x47 M2 receptor 4MQT M2 receptor 4MQT
TM3 130 3.48x48 M2 receptor 4MQT PAF receptor 5ZKP
TM3 131 3.49x49 M2 receptor 4MQT M2 receptor 4MQT
TM3 132 3.50x50 M2 receptor 4MQT M2 receptor 4MQT
TM3 133 3.51x51 M2 receptor 4MQT LPA6 receptor 5XSZ
TM3 134 3.52x52 M2 receptor 4MQT A1 receptor 6D9H
TM3 135 3.53x53 M2 receptor 4MQT AT2 receptor 5UNG
TM3 136 3.54x54 M2 receptor 4MQT M2 receptor 4MQT
TM3 137 3.55x55 M2 receptor 4MQT M2 receptor 4MQT
TM3 138 3.56x56 M2 receptor 4MQT CB1 receptor 5XRA
ICL2 139 34.50x50 - - - -
ICL2 140 34.51x51 D3 receptor 3PBL D3 receptor 3PBL
ICL2 141 34.52x52 D3 receptor 3PBL Rhodopsin 4ZWJ
ICL2 142 34.53x53 D3 receptor 3PBL D3 receptor 3PBL
ICL2 143 34.54x54 D3 receptor 3PBL LPA6 receptor 5XSZ
ICL2 144 34.55x55 D3 receptor 3PBL 5-HT1B receptor 6G79
ICL2 145 34.56x56 D3 receptor 3PBL - -
ICL2 146 34.57x57 D3 receptor 3PBL - -
ICL2 147 34.58x58 - - - -
TM4 148 4.38x38 M2 receptor 4MQT - -
TM4 149 4.39x39 M2 receptor 4MQT M2 receptor 4MQT
TM4 150 4.40x40 M2 receptor 4MQT μ receptor 5C1M
TM4 151 4.41x41 M2 receptor 4MQT 5-HT1B receptor 6G79
TM4 152 4.42x42 M2 receptor 4MQT M2 receptor 4MQT
TM4 153 4.43x43 M2 receptor 4MQT CB1 receptor 5XRA
TM4 154 4.44x44 M2 receptor 4MQT - -
TM4 155 4.45x45 M2 receptor 4MQT 5-HT2C receptor 6BQG
TM4 156 4.46x46 M2 receptor 4MQT - -
TM4 157 4.47x47 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM4 158 4.48x48 M2 receptor 4MQT 5-HT1B receptor 6G79
TM4 159 4.49x49 M2 receptor 4MQT 5-HT1B receptor 6G79
TM4 160 4.50x50 M2 receptor 4MQT M2 receptor 4MQT
TM4 161 4.51x51 M2 receptor 4MQT M2 receptor 4MQT
TM4 162 4.52x52 M2 receptor 4MQT M2 receptor 4MQT
TM4 163 4.53x53 M2 receptor 4MQT Rhodopsin 5DYS
TM4 164 4.54x54 M2 receptor 4MQT M2 receptor 4MQT
TM4 165 4.55x55 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM4 166 4.56x56 M2 receptor 4MQT M2 receptor 4MQT
TM4 167 4.57x57 D2 receptor 6CM4 - -
TM4 168 4.58x59 D2 receptor 6CM4 - -
TM4 169 4.59x60 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM4 170 4.60x61 M2 receptor 4MQT NOP receptor 5DHG
TM4 171 4.61x62 M2 receptor 4MQT PAF receptor 5ZKP
TM4 172 4.62x63 M2 receptor 4MQT κ receptor 6B73
TM4 173 4.63x64 M2 receptor 4MQT - -
ECL2 174 - - - -
ECL2 175 ETB receptor 5X93 - -
ECL2 176 ETB receptor 5X93 - -
ECL2 177 ETB receptor 5X93 - -
ECL2 178 ETB receptor 5X93 - -
ECL2 179 ETB receptor 5X93 - -
ECL2 180 ETB receptor 5X93 - -
ECL2 181 ETB receptor 5X93 - -
ECL2 182 ETB receptor 5X93 - -
ECL2 183 ETB receptor 5X93 - -
ECL2 184 ETB receptor 5X93 - -
ECL2 185 ETB receptor 5X93 - -
ECL2 186 ETB receptor 5X93 - -
ECL2 187 - - - -
ECL2 188 45.50x50 M2 receptor 4MQT M2 receptor 4MQT
ECL2 189 45.51x51 M2 receptor 4MQT M2 receptor 4MQT
ECL2 190 45.52x52 M2 receptor 4MQT BLT1 receptor 5X33
ECL2 191 M2 receptor 4MQT - -
ECL2 192 M2 receptor 4MQT M2 receptor 4MQT
ECL2 193 M2 receptor 4MQT - -
ECL2 194 M2 receptor 4MQT - -
TM5 195 5.35x36 M2 receptor 4MQT M2 receptor 4MQT
TM5 196 5.36x37 M2 receptor 4MQT - -
TM5 197 5.37x38 M2 receptor 4MQT PAR1 3VW7
TM5 198 5.38x39 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM5 199 5.39x40 M2 receptor 4MQT CB1 receptor 5XRA
TM5 200 5.40x41 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM5 201 5.41x42 M2 receptor 4MQT AT1 receptor 4ZUD
TM5 202 5.42x43 M2 receptor 4MQT - -
TM5 203 5.43x44 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM5 204 5.44x45 M2 receptor 4MQT LPA6 receptor 5XSZ
TM5 205 5.45x46 M2 receptor 4MQT AT2 receptor 5UNG
TM5 206 5.46x461 M2 receptor 4MQT - -
TM5 207 5.47x47 M2 receptor 4MQT M2 receptor 4MQT
TM5 208 5.48x48 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM5 209 5.49x49 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM5 210 5.50x50 M2 receptor 4MQT M2 receptor 4MQT
TM5 211 5.51x51 M2 receptor 4MQT PAF receptor 5ZKP
TM5 212 5.52x52 M2 receptor 4MQT κ receptor 6B73
TM5 213 5.53x53 M2 receptor 4MQT S1P1 receptor 3V2Y
TM5 214 5.54x54 M2 receptor 4MQT BLT1 receptor 5X33
TM5 215 5.55x55 M2 receptor 4MQT M2 receptor 4MQT
TM5 216 5.56x56 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM5 217 5.57x57 M2 receptor 4MQT H1 receptor 3RZE
TM5 218 5.58x58 M2 receptor 4MQT NTS1 receptor 5T04
TM5 219 5.59x59 M2 receptor 4MQT A1 receptor 6D9H
TM5 220 5.60x60 M2 receptor 4MQT PAR1 3VW7
TM5 221 5.61x61 M2 receptor 4MQT M2 receptor 4MQT
TM5 222 5.62x62 M2 receptor 4MQT 5-HT1B receptor 6G79
TM5 223 5.63x63 M2 receptor 4MQT μ receptor 5C1M
TM5 224 5.64x64 M2 receptor 4MQT - -
TM5 225 5.65x65 M2 receptor 4MQT A1 receptor 6D9H
TM5 226 5.66x66 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM5 227 5.67x67 β2-adrenoceptor 3SN6 β2-adrenoceptor 3SN6
TM5 228 5.68x68 β2-adrenoceptor 3SN6 5-HT1B receptor 6G79
TM5 229 5.69x69 β2-adrenoceptor 3SN6 - -
TM5 230 5.70x70 β2-adrenoceptor 3SN6 - -
TM5 231 5.71x71 β2-adrenoceptor 3SN6 - -
TM5 232 5.72x72 β2-adrenoceptor 3SN6 - -
TM5 233 5.73x73 β2-adrenoceptor 3SN6 - -
TM5 234 5.74x74 β2-adrenoceptor 3SN6 - -
TM5 235 5.75x75 β2-adrenoceptor 3SN6 - -
ICL3 236 - - - -
ICL3 237 - - - -
ICL3 238 - - - -
ICL3 239 - - - -
ICL3 240 - - - -
ICL3 342 - - - -
ICL3 343 - - - -
ICL3 344 - - - -
ICL3 345 - - - -
ICL3 346 - - - -
TM6 347 6.24x24 5-HT2B receptor 5TVN NOP receptor 5DHG
TM6 348 6.25x25 5-HT2B receptor 5TVN - -
TM6 349 6.26x26 5-HT2B receptor 5TVN NTS1 receptor 5T04
TM6 350 6.27x27 M2 receptor 4MQT M1 receptor 5CXV
TM6 351 6.28x28 M2 receptor 4MQT M2 receptor 4MQT
TM6 352 6.29x29 M2 receptor 4MQT 5-HT1B receptor 6G79
TM6 353 6.30x30 M2 receptor 4MQT CB1 receptor 5XRA
TM6 354 6.31x31 M2 receptor 4MQT 5-HT2C receptor 6BQG
TM6 355 6.32x32 M2 receptor 4MQT M2 receptor 4MQT
TM6 356 6.33x33 M2 receptor 4MQT M2 receptor 4MQT
TM6 357 6.34x34 M2 receptor 4MQT A1 receptor 6D9H
TM6 358 6.35x35 M2 receptor 4MQT 5-HT1B receptor 6G79
TM6 359 6.36x36 M2 receptor 4MQT A1 receptor 6D9H
TM6 360 6.37x37 M2 receptor 4MQT 5-HT1B receptor 6G79
TM6 361 6.38x38 M2 receptor 4MQT A1 receptor 6D9H
TM6 362 6.39x39 M2 receptor 4MQT κ receptor 6B73
TM6 363 6.40x40 M2 receptor 4MQT M2 receptor 4MQT
TM6 364 6.41x41 M2 receptor 4MQT κ receptor 6B73
TM6 365 6.42x42 M2 receptor 4MQT S1P1 receptor 3V2Y
TM6 366 6.43x43 M2 receptor 4MQT LPA6 receptor 5XSZ
TM6 367 6.44x44 M2 receptor 4MQT M2 receptor 4MQT
TM6 368 6.45x45 M2 receptor 4MQT - -
TM6 369 6.46x46 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM6 370 6.47x47 M2 receptor 4MQT 5-HT1B receptor 6G79
TM6 371 6.48x48 M2 receptor 4MQT M2 receptor 4MQT
TM6 372 6.49x49 M2 receptor 4MQT M2 receptor 4MQT
TM6 373 6.50x50 M2 receptor 4MQT M2 receptor 4MQT
TM6 374 6.51x51 M2 receptor 4MQT M2 receptor 4MQT
TM6 375 6.52x52 M2 receptor 4MQT Y1 receptor 5ZBH
TM6 376 6.53x53 M2 receptor 4MQT US28 4XT1
TM6 377 6.54x54 M2 receptor 4MQT A1 receptor 6D9H
TM6 378 6.55x55 M2 receptor 4MQT CB1 receptor 5XRA
TM6 379 6.56x56 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM6 380 6.57x57 M2 receptor 4MQT M2 receptor 4MQT
TM6 381 6.58x58 M2 receptor 4MQT - -
TM6 382 6.59x59 M2 receptor 4MQT κ receptor 6B73
TM6 383 6.60x60 M2 receptor 4MQT - -
TM6 384 6.61x61 M2 receptor 4MQT M2 receptor 4MQT
ECL3 385 - - - -
ECL3 386 D4 receptor 5WIV - -
ECL3 387 D4 receptor 5WIV - -
ECL3 388 D4 receptor 5WIV - -
ECL3 389 - - - -
TM7 390 7.31x30 M2 receptor 4MQT M2 receptor 4MQT
TM7 391 7.32x31 M2 receptor 4MQT AT2 receptor 5UNG
TM7 392 7.33x32 M2 receptor 4MQT NTS1 receptor 5T04
TM7 393 7.34x33 M2 receptor 4MQT OX2 receptor 5WS3
TM7 394 7.35x34 M2 receptor 4MQT β2-adrenoceptor 3SN6
TM7 395 7.36x35 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM7 396 7.37x36 M2 receptor 4MQT - -
TM7 397 7.38x37 M2 receptor 4MQT OX2 receptor 5WS3
TM7 398 7.39x38 M2 receptor 4MQT - -
TM7 399 7.40x39 M2 receptor 4MQT M2 receptor 4MQT
TM7 400 7.41x40 M2 receptor 4MQT M2 receptor 4MQT
TM7 401 7.42x41 M2 receptor 4MQT PAF receptor 5ZKP
TM7 402 7.43x42 M2 receptor 4MQT - -
TM7 403 7.44x43 M2 receptor 4MQT NTS1 receptor 5T04
TM7 404 7.45x45 M2 receptor 4MQT M2 receptor 4MQT
TM7 405 7.46x46 M2 receptor 4MQT M2 receptor 4MQT
TM7 406 7.47x47 M2 receptor 4MQT A1 receptor 6D9H
TM7 407 7.48x48 M2 receptor 4MQT 5-HT2B receptor 5TUD
TM7 408 7.49x49 M2 receptor 4MQT M2 receptor 4MQT
TM7 409 7.50x50 M2 receptor 4MQT M2 receptor 4MQT
TM7 410 7.51x51 M2 receptor 4MQT μ receptor 6DDF
TM7 411 7.52x52 M2 receptor 4MQT μ receptor 6DDF
TM7 412 7.53x53 M2 receptor 4MQT M2 receptor 4MQT
TM7 413 7.54x54 M2 receptor 4MQT H1 receptor 3RZE
TM7 414 7.55x55 M2 receptor 4MQT M2 receptor 4MQT
TM7 415 7.56x56 M2 receptor 4MQT M2 receptor 4MQT
H8 416 8.47x47 M2 receptor 4MQT - -
H8 417 8.48x48 M2 receptor 4MQT PAR2 5NDD
H8 418 8.49x49 M2 receptor 4MQT P2Y12 receptor 4NTJ
H8 419 8.50x50 M2 receptor 4MQT M2 receptor 4MQT
H8 420 8.51x51 M2 receptor 4MQT 5-HT2B receptor 5TUD
H8 421 8.52x52 M2 receptor 4MQT 5-HT2C receptor 6BQG
H8 422 8.53x53 M2 receptor 4MQT 5-HT1B receptor 6G79
H8 423 8.54x54 M2 receptor 4MQT M2 receptor 4MQT
H8 424 8.55x55 M2 receptor 4MQT PAF receptor 5ZKP
H8 425 8.56x56 M2 receptor 4MQT A1 receptor 6D9H
H8 426 8.57x57 M2 receptor 4MQT M2 receptor 4MQT
H8 427 8.58x58 M2 receptor 4MQT M2 receptor 4MQT
H8 428 8.59x59 M2 receptor 4MQT β2-adrenoceptor 3SN6
C-term 429 - - - -
C-term 430 - - - -
C-term 431 - - - -
C-term 432 - - - -
C-term 433 - - - -