H3 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive (Δ distance (Å): 0.46 docs)

VERSION

2018-07-10

MAIN TEMPLATE

H1 receptor (sequence similarity: 58%) PDB: 3RZE

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 79.1 10.9 9.9
Side-chains 26.5 48.3 25.2

Number of backbone templates: 7
Number of rotamer templates: 36

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4U15
3RZE
3PBL
6CM4
3SN6
5TVN
5WIV
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 31 - - - -
N-term 32 - - - -
N-term 33 - - - -
N-term 34 - - - -
N-term 35 - - - -
TM1 36 1.34x34 M3 receptor 4U15 OX2 receptor 5WS3
TM1 37 1.35x35 M3 receptor 4U15 OX2 receptor 5WS3
TM1 38 1.36x36 M3 receptor 4U15 M3 receptor 4U15
TM1 39 1.37x37 M3 receptor 4U15 OX2 receptor 5WS3
TM1 40 1.38x38 H1 receptor 3RZE M3 receptor 4U15
TM1 41 1.39x39 H1 receptor 3RZE β2-adrenoceptor 5JQH
TM1 42 1.40x40 H1 receptor 3RZE C5a1 receptor 5O9H
TM1 43 1.41x41 H1 receptor 3RZE M1 receptor 5CXV
TM1 44 1.42x42 H1 receptor 3RZE M3 receptor 4U15
TM1 45 1.43x43 H1 receptor 3RZE D2 receptor 6CM4
TM1 46 1.44x44 H1 receptor 3RZE OX2 receptor 5WS3
TM1 47 1.45x45 H1 receptor 3RZE M1 receptor 5CXV
TM1 48 1.46x46 H1 receptor 3RZE H1 receptor 3RZE
TM1 49 1.47x47 H1 receptor 3RZE H1 receptor 3RZE
TM1 50 1.48x48 H1 receptor 3RZE NOP receptor 5DHG
TM1 51 1.49x49 H1 receptor 3RZE M3 receptor 4U15
TM1 52 1.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM1 53 1.51x51 H1 receptor 3RZE C5a1 receptor 5O9H
TM1 54 1.52x52 H1 receptor 3RZE H1 receptor 3RZE
TM1 55 1.53x53 H1 receptor 3RZE H1 receptor 3RZE
TM1 56 1.54x54 H1 receptor 3RZE M4 receptor 5DSG
TM1 57 1.55x55 H1 receptor 3RZE M4 receptor 5DSG
TM1 58 1.56x56 H1 receptor 3RZE H1 receptor 3RZE
TM1 59 1.57x57 H1 receptor 3RZE M3 receptor 4U15
TM1 60 1.58x58 H1 receptor 3RZE μ receptor 4DKL
TM1 61 1.59x59 H1 receptor 3RZE FFA1 receptor 5TZY
TM1 62 1.60x60 H1 receptor 3RZE - -
ICL1 63 12.48x48 H1 receptor 3RZE A2A receptor 3VG9
ICL1 64 12.49x49 H1 receptor 3RZE CB1 receptor 5TGZ
ICL1 65 12.50x50 H1 receptor 3RZE H1 receptor 3RZE
ICL1 66 12.51x51 H1 receptor 3RZE OX2 receptor 5WS3
TM2 67 2.37x37 H1 receptor 3RZE H1 receptor 3RZE
TM2 68 2.38x38 H1 receptor 3RZE - -
TM2 69 2.39x39 H1 receptor 3RZE M3 receptor 4U15
TM2 70 2.40x40 H1 receptor 3RZE H1 receptor 3RZE
TM2 71 2.41x41 H1 receptor 3RZE - -
TM2 72 2.42x42 H1 receptor 3RZE M3 receptor 4U15
TM2 73 2.43x43 H1 receptor 3RZE M3 receptor 4U15
TM2 74 2.44x44 H1 receptor 3RZE M3 receptor 4U15
TM2 75 2.45x45 H1 receptor 3RZE OX2 receptor 5WS3
TM2 76 2.46x46 H1 receptor 3RZE H1 receptor 3RZE
TM2 77 2.47x47 H1 receptor 3RZE M3 receptor 4U15
TM2 78 2.48x48 H1 receptor 3RZE 5-HT2C receptor 6BQH
TM2 79 2.49x49 H1 receptor 3RZE S1P1 receptor 3V2Y
TM2 80 2.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM2 81 2.51x51 H1 receptor 3RZE LPA1 receptor 4Z35
TM2 82 2.52x52 H1 receptor 3RZE D2 receptor 6CM4
TM2 83 2.53x53 H1 receptor 3RZE H1 receptor 3RZE
TM2 84 2.54x54 H1 receptor 3RZE H1 receptor 3RZE
TM2 85 2.55x55 H1 receptor 3RZE H1 receptor 3RZE
TM2 86 2.56x551 H1 receptor 3RZE M1 receptor 5CXV
TM2 87 2.57x56 H1 receptor 3RZE OX2 receptor 5WS3
TM2 88 2.58x57 H1 receptor 3RZE A1 receptor 5UEN
TM2 89 2.59x58 H1 receptor 3RZE H1 receptor 3RZE
TM2 90 2.60x59 H1 receptor 3RZE M3 receptor 4U15
TM2 91 2.61x60 H1 receptor 3RZE M1 receptor 5CXV
TM2 92 2.62x61 H1 receptor 3RZE D2 receptor 6CM4
TM2 93 2.63x62 H1 receptor 3RZE - -
TM2 94 2.64x63 H1 receptor 3RZE H1 receptor 3RZE
TM2 95 2.65x64 H1 receptor 3RZE - -
TM2 96 2.66x65 H1 receptor 3RZE H1 receptor 3RZE
TM2 97 2.67x66 H1 receptor 3RZE D3 receptor 3PBL
ECL1 98 H1 receptor 3RZE - -
ECL1 99 23.49x49 H1 receptor 3RZE AT1 receptor 4ZUD
ECL1 100 23.50x50 H1 receptor 3RZE H1 receptor 3RZE
ECL1 101 23.51x51 H1 receptor 3RZE β2-adrenoceptor 5JQH
ECL1 102 23.52x52 H1 receptor 3RZE β2-adrenoceptor 5JQH
TM3 103 3.21x21 H1 receptor 3RZE H1 receptor 3RZE
TM3 104 3.22x22 H1 receptor 3RZE H1 receptor 3RZE
TM3 105 3.23x23 H1 receptor 3RZE - -
TM3 106 3.24x24 H1 receptor 3RZE H1 receptor 3RZE
TM3 107 3.25x25 H1 receptor 3RZE H1 receptor 3RZE
TM3 108 3.26x26 H1 receptor 3RZE OX2 receptor 5WS3
TM3 109 3.27x27 H1 receptor 3RZE M3 receptor 4U15
TM3 110 3.28x28 H1 receptor 3RZE H1 receptor 3RZE
TM3 111 3.29x29 H1 receptor 3RZE H1 receptor 3RZE
TM3 112 3.30x30 H1 receptor 3RZE CXCR4 3ODU
TM3 113 3.31x31 H1 receptor 3RZE Y1 receptor 5ZBH
TM3 114 3.32x32 H1 receptor 3RZE H1 receptor 3RZE
TM3 115 3.33x33 H1 receptor 3RZE H1 receptor 3RZE
TM3 116 3.34x34 H1 receptor 3RZE 5-HT2C receptor 6BQH
TM3 117 3.35x35 H1 receptor 3RZE D4 receptor 5WIV
TM3 118 3.36x36 H1 receptor 3RZE D2 receptor 6CM4
TM3 119 3.37x37 H1 receptor 3RZE H1 receptor 3RZE
TM3 120 3.38x38 H1 receptor 3RZE A1 receptor 5UEN
TM3 121 3.39x39 H1 receptor 3RZE H1 receptor 3RZE
TM3 122 3.40x40 H1 receptor 3RZE D2 receptor 6CM4
TM3 123 3.41x41 H1 receptor 3RZE H1 receptor 3RZE
TM3 124 3.42x42 H1 receptor 3RZE M3 receptor 4U15
TM3 125 3.43x43 H1 receptor 3RZE CCR2 5T1A
TM3 126 3.44x44 H1 receptor 3RZE NTS1 receptor 4BUO
TM3 127 3.45x45 H1 receptor 3RZE M1 receptor 5CXV
TM3 128 3.46x46 H1 receptor 3RZE M3 receptor 4U15
TM3 129 3.47x47 H1 receptor 3RZE M3 receptor 4U15
TM3 130 3.48x48 H1 receptor 3RZE PAF receptor 5ZKP
TM3 131 3.49x49 H1 receptor 3RZE H1 receptor 3RZE
TM3 132 3.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM3 133 3.51x51 H1 receptor 3RZE D4 receptor 5WIV
TM3 134 3.52x52 H1 receptor 3RZE A1 receptor 5UEN
TM3 135 3.53x53 H1 receptor 3RZE H1 receptor 3RZE
TM3 136 3.54x54 H1 receptor 3RZE H1 receptor 3RZE
TM3 137 3.55x55 H1 receptor 3RZE M3 receptor 4U15
TM3 138 3.56x56 H1 receptor 3RZE M3 receptor 4U15
ICL2 139 34.50x50 - - - -
ICL2 140 34.51x51 D3 receptor 3PBL D3 receptor 3PBL
ICL2 141 34.52x52 D3 receptor 3PBL M1 receptor 5CXV
ICL2 142 34.53x53 D3 receptor 3PBL D3 receptor 3PBL
ICL2 143 34.54x54 D3 receptor 3PBL M3 receptor 4U15
ICL2 144 34.55x55 D3 receptor 3PBL M3 receptor 4U15
ICL2 145 34.56x56 D3 receptor 3PBL - -
ICL2 146 34.57x57 D3 receptor 3PBL - -
ICL2 147 34.58x58 - - - -
TM4 148 4.38x38 H1 receptor 3RZE - -
TM4 149 4.39x39 H1 receptor 3RZE M3 receptor 4U15
TM4 150 4.40x40 H1 receptor 3RZE M1 receptor 5CXV
TM4 151 4.41x41 H1 receptor 3RZE H1 receptor 3RZE
TM4 152 4.42x42 H1 receptor 3RZE H1 receptor 3RZE
TM4 153 4.43x43 H1 receptor 3RZE CCR2 5T1A
TM4 154 4.44x44 H1 receptor 3RZE - -
TM4 155 4.45x45 H1 receptor 3RZE 5-HT2C receptor 6BQH
TM4 156 4.46x46 H1 receptor 3RZE - -
TM4 157 4.47x47 H1 receptor 3RZE H1 receptor 3RZE
TM4 158 4.48x48 H1 receptor 3RZE M3 receptor 4U15
TM4 159 4.49x49 H1 receptor 3RZE D2 receptor 6CM4
TM4 160 4.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM4 161 4.51x51 H1 receptor 3RZE M3 receptor 4U15
TM4 162 4.52x52 H1 receptor 3RZE H1 receptor 3RZE
TM4 163 4.53x53 H1 receptor 3RZE D3 receptor 3PBL
TM4 164 4.54x54 H1 receptor 3RZE H1 receptor 3RZE
TM4 165 4.55x55 M3 receptor 4U15 M3 receptor 4U15
TM4 166 4.56x56 M3 receptor 4U15 M3 receptor 4U15
TM4 167 4.57x57 D2 receptor 6CM4 - -
TM4 168 4.58x59 D2 receptor 6CM4 - -
TM4 169 4.59x60 H1 receptor 3RZE H1 receptor 3RZE
TM4 170 4.60x61 H1 receptor 3RZE NOP receptor 5DHG
TM4 171 4.61x62 H1 receptor 3RZE NOP receptor 5DHG
TM4 172 4.62x63 H1 receptor 3RZE PAR1 3VW7
TM4 173 4.63x64 M3 receptor 4U15 - -
ECL2 174 H1 receptor 3RZE H1 receptor 3RZE
ECL2 175 H1 receptor 3RZE - -
ECL2 176 H1 receptor 3RZE - -
ECL2 177 - - - -
ECL2 178 - - - -
ECL2 179 - - - -
ECL2 180 - - - -
ECL2 181 - - - -
ECL2 182 - - - -
ECL2 183 - - - -
ECL2 184 H1 receptor 3RZE - -
ECL2 185 H1 receptor 3RZE - -
ECL2 186 H1 receptor 3RZE - -
ECL2 187 H1 receptor 3RZE - -
ECL2 188 45.50x50 H1 receptor 3RZE H1 receptor 3RZE
ECL2 189 45.51x51 H1 receptor 3RZE M1 receptor 5CXV
ECL2 190 45.52x52 H1 receptor 3RZE - -
ECL2 191 H1 receptor 3RZE H1 receptor 3RZE
ECL2 192 H1 receptor 3RZE - -
ECL2 193 H1 receptor 3RZE H1 receptor 3RZE
ECL2 194 H1 receptor 3RZE - -
TM5 195 5.35x36 H1 receptor 3RZE M4 receptor 5DSG
TM5 196 5.36x37 H1 receptor 3RZE - -
TM5 197 5.37x38 H1 receptor 3RZE PAR1 3VW7
TM5 198 5.38x39 H1 receptor 3RZE H1 receptor 3RZE
TM5 199 5.39x40 H1 receptor 3RZE LPA1 receptor 4Z35
TM5 200 5.40x41 H1 receptor 3RZE D3 receptor 3PBL
TM5 201 5.41x42 H1 receptor 3RZE AT1 receptor 4ZUD
TM5 202 5.42x43 H1 receptor 3RZE - -
TM5 203 5.43x44 H1 receptor 3RZE D2 receptor 6CM4
TM5 204 5.44x45 H1 receptor 3RZE S1P1 receptor 3V2Y
TM5 205 5.45x46 H1 receptor 3RZE AT1 receptor 4YAY
TM5 206 5.46x461 H1 receptor 3RZE - -
TM5 207 5.47x47 H1 receptor 3RZE H1 receptor 3RZE
TM5 208 5.48x48 H1 receptor 3RZE D4 receptor 5WIV
TM5 209 5.49x49 H1 receptor 3RZE 5-HT2B receptor 4IB4
TM5 210 5.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM5 211 5.51x51 H1 receptor 3RZE D2 receptor 6CM4
TM5 212 5.52x52 H1 receptor 3RZE H1 receptor 3RZE
TM5 213 5.53x53 H1 receptor 3RZE S1P1 receptor 3V2Y
TM5 214 5.54x54 H1 receptor 3RZE BLT1 receptor 5X33
TM5 215 5.55x55 H1 receptor 3RZE M3 receptor 4U15
TM5 216 5.56x56 H1 receptor 3RZE β2-adrenoceptor 5JQH
TM5 217 5.57x57 H1 receptor 3RZE H1 receptor 3RZE
TM5 218 5.58x58 H1 receptor 3RZE NTS1 receptor 4BUO
TM5 219 5.59x59 H1 receptor 3RZE OX2 receptor 5WS3
TM5 220 5.60x60 H1 receptor 3RZE PAR1 3VW7
TM5 221 5.61x61 H1 receptor 3RZE H1 receptor 3RZE
TM5 222 5.62x62 H1 receptor 3RZE H1 receptor 3RZE
TM5 223 5.63x63 H1 receptor 3RZE M4 receptor 5DSG
TM5 224 5.64x64 H1 receptor 3RZE - -
TM5 225 5.65x65 H1 receptor 3RZE A1 receptor 5UEN
TM5 226 5.66x66 β2-adrenoceptor 3SN6 D4 receptor 5WIV
TM5 227 5.67x67 β2-adrenoceptor 3SN6 β2-adrenoceptor 3SN6
TM5 228 5.68x68 β2-adrenoceptor 3SN6 D2 receptor 6CM4
TM5 229 5.69x69 β2-adrenoceptor 3SN6 - -
TM5 230 5.70x70 β2-adrenoceptor 3SN6 - -
TM5 231 5.71x71 β2-adrenoceptor 3SN6 - -
TM5 232 5.72x72 β2-adrenoceptor 3SN6 - -
TM5 233 5.73x73 β2-adrenoceptor 3SN6 - -
TM5 234 5.74x74 β2-adrenoceptor 3SN6 - -
TM5 235 5.75x75 β2-adrenoceptor 3SN6 - -
ICL3 236 - - - -
ICL3 237 - - - -
ICL3 238 - - - -
ICL3 239 - - - -
ICL3 240 - - - -
ICL3 342 - - - -
ICL3 343 - - - -
ICL3 344 - - - -
ICL3 345 - - - -
ICL3 346 - - - -
TM6 347 6.24x24 5-HT2B receptor 5TVN NOP receptor 5DHG
TM6 348 6.25x25 5-HT2B receptor 5TVN - -
TM6 349 6.26x26 5-HT2B receptor 5TVN NTS1 receptor 4BUO
TM6 350 6.27x27 5-HT2B receptor 5TVN M1 receptor 5CXV
TM6 351 6.28x28 H1 receptor 3RZE Y1 receptor 5ZBH
TM6 352 6.29x29 H1 receptor 3RZE H1 receptor 3RZE
TM6 353 6.30x30 H1 receptor 3RZE CB1 receptor 5TGZ
TM6 354 6.31x31 H1 receptor 3RZE H1 receptor 3RZE
TM6 355 6.32x32 H1 receptor 3RZE H1 receptor 3RZE
TM6 356 6.33x33 H1 receptor 3RZE M4 receptor 5DSG
TM6 357 6.34x34 H1 receptor 3RZE H1 receptor 3RZE
TM6 358 6.35x35 H1 receptor 3RZE H1 receptor 3RZE
TM6 359 6.36x36 H1 receptor 3RZE A1 receptor 5UEN
TM6 360 6.37x37 H1 receptor 3RZE H1 receptor 3RZE
TM6 361 6.38x38 H1 receptor 3RZE D2 receptor 6CM4
TM6 362 6.39x39 H1 receptor 3RZE D4 receptor 5WIV
TM6 363 6.40x40 H1 receptor 3RZE H1 receptor 3RZE
TM6 364 6.41x41 H1 receptor 3RZE D4 receptor 5WIV
TM6 365 6.42x42 H1 receptor 3RZE S1P1 receptor 3V2Y
TM6 366 6.43x43 H1 receptor 3RZE LPA6 receptor 5XSZ
TM6 367 6.44x44 H1 receptor 3RZE H1 receptor 3RZE
TM6 368 6.45x45 H1 receptor 3RZE - -
TM6 369 6.46x46 H1 receptor 3RZE H1 receptor 3RZE
TM6 370 6.47x47 H1 receptor 3RZE H1 receptor 3RZE
TM6 371 6.48x48 H1 receptor 3RZE H1 receptor 3RZE
TM6 372 6.49x49 H1 receptor 3RZE M2 receptor 3UON
TM6 373 6.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM6 374 6.51x51 H1 receptor 3RZE H1 receptor 3RZE
TM6 375 6.52x52 H1 receptor 3RZE Y1 receptor 5ZBH
TM6 376 6.53x53 H1 receptor 3RZE D3 receptor 3PBL
TM6 377 6.54x54 H1 receptor 3RZE OX2 receptor 5WS3
TM6 378 6.55x55 H1 receptor 3RZE CB1 receptor 5TGZ
TM6 379 6.56x56 H1 receptor 3RZE D4 receptor 5WIV
TM6 380 6.57x57 H1 receptor 3RZE M2 receptor 3UON
TM6 381 6.58x58 H1 receptor 3RZE - -
TM6 382 6.59x59 H1 receptor 3RZE H1 receptor 3RZE
TM6 383 6.60x60 H1 receptor 3RZE - -
TM6 384 6.61x61 H1 receptor 3RZE H1 receptor 3RZE
ECL3 385 - - - -
ECL3 386 D4 receptor 5WIV - -
ECL3 387 D4 receptor 5WIV - -
ECL3 388 D4 receptor 5WIV - -
ECL3 389 - - - -
TM7 390 7.31x30 H1 receptor 3RZE M3 receptor 4U15
TM7 391 7.32x31 H1 receptor 3RZE M4 receptor 5DSG
TM7 392 7.33x32 H1 receptor 3RZE NTS1 receptor 4BUO
TM7 393 7.34x33 H1 receptor 3RZE OX2 receptor 5WS3
TM7 394 7.35x34 H1 receptor 3RZE D2 receptor 6CM4
TM7 395 7.36x35 H1 receptor 3RZE M1 receptor 5CXV
TM7 396 7.37x36 H1 receptor 3RZE - -
TM7 397 7.38x37 H1 receptor 3RZE OX2 receptor 5WS3
TM7 398 7.39x38 H1 receptor 3RZE - -
TM7 399 7.40x39 H1 receptor 3RZE H1 receptor 3RZE
TM7 400 7.41x40 H1 receptor 3RZE H1 receptor 3RZE
TM7 401 7.42x41 H1 receptor 3RZE PAF receptor 5ZKP
TM7 402 7.43x42 H1 receptor 3RZE - -
TM7 403 7.44x43 H1 receptor 3RZE OX2 receptor 5WS3
TM7 404 7.45x45 H1 receptor 3RZE H1 receptor 3RZE
TM7 405 7.46x46 H1 receptor 3RZE H1 receptor 3RZE
TM7 406 7.47x47 H1 receptor 3RZE D2 receptor 6CM4
TM7 407 7.48x48 H1 receptor 3RZE M3 receptor 4U15
TM7 408 7.49x49 H1 receptor 3RZE H1 receptor 3RZE
TM7 409 7.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM7 410 7.51x51 H1 receptor 3RZE M3 receptor 4U15
TM7 411 7.52x52 H1 receptor 3RZE κ receptor 4DJH
TM7 412 7.53x53 H1 receptor 3RZE H1 receptor 3RZE
TM7 413 7.54x54 H1 receptor 3RZE H1 receptor 3RZE
TM7 414 7.55x55 H1 receptor 3RZE H1 receptor 3RZE
TM7 415 7.56x56 H1 receptor 3RZE H1 receptor 3RZE
H8 416 8.47x47 H1 receptor 3RZE - -
H8 417 8.48x48 H1 receptor 3RZE PAR2 5NDD
H8 418 8.49x49 H1 receptor 3RZE P2Y12 receptor 4NTJ
H8 419 8.50x50 H1 receptor 3RZE H1 receptor 3RZE
H8 420 8.51x51 H1 receptor 3RZE M3 receptor 4U15
H8 421 8.52x52 H1 receptor 3RZE 5-HT2C receptor 6BQH
H8 422 8.53x53 H1 receptor 3RZE D2 receptor 6CM4
H8 423 8.54x54 H1 receptor 3RZE H1 receptor 3RZE
H8 424 8.55x55 H1 receptor 3RZE apelin receptor 5VBL
H8 425 8.56x56 H1 receptor 3RZE D3 receptor 3PBL
H8 426 8.57x57 H1 receptor 3RZE M3 receptor 4U15
H8 427 8.58x58 H1 receptor 3RZE H1 receptor 3RZE
H8 428 8.59x59 H1 receptor 3RZE β2-adrenoceptor 5JQH
C-term 429 H1 receptor 3RZE H1 receptor 3RZE
C-term 430 - - - -
C-term 431 - - - -
C-term 432 - - - -
C-term 433 - - - -