LGR4 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 9.18 docs)

VERSION

2018-07-10

MAIN TEMPLATE

A1 receptor (sequence similarity: 36%) PDB: 6D9H

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 75.5 11.2 13.3
Side-chains 16.0 52.7 31.3

Number of backbone templates: 7
Number of rotamer templates: 38

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6D9H
5UEN
4ZUD
6BQH
4PXZ
5UNG
4Z35
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 531 - - - -
N-term 532 - - - -
N-term 533 - - - -
N-term 534 - - - -
N-term 535 A1 receptor 6D9H A1 receptor 6D9H
TM1 536 1.30x30 A1 receptor 6D9H PAR2 5NDD
TM1 537 1.31x31 A1 receptor 6D9H CCR2 5T1A
TM1 538 1.32x32 A1 receptor 6D9H LPA1 receptor 4Z35
TM1 539 1.33x33 A1 receptor 6D9H OX2 receptor 5WS3
TM1 540 1.34x34 A1 receptor 6D9H Rhodopsin 4ZWJ
TM1 541 1.35x35 A1 receptor 6D9H AT2 receptor 5UNG
TM1 542 1.36x36 A1 receptor 6D9H - -
TM1 543 1.37x37 A1 receptor 6D9H M2 receptor 4MQT
TM1 544 1.38x38 A1 receptor 6D9H M1 receptor 5CXV
TM1 545 1.39x39 A1 receptor 6D9H - -
TM1 546 1.40x40 A1 receptor 6D9H CCR9 5LWE
TM1 547 1.41x41 A1 receptor 6D9H M3 receptor 4U15
TM1 548 1.42x42 A1 receptor 6D9H A1 receptor 6D9H
TM1 549 1.43x43 A1 receptor 6D9H AT2 receptor 5UNG
TM1 550 1.44x44 A1 receptor 6D9H A1 receptor 6D9H
TM1 551 1.45x45 A1 receptor 6D9H A1 receptor 6D9H
TM1 552 1.46x46 A1 receptor 6D9H A2A receptor 5G53
TM1 553 1.47x47 A1 receptor 6D9H μ receptor 5C1M
TM1 554 1.48x48 A1 receptor 6D9H μ receptor 5C1M
TM1 555 1.49x49 A1 receptor 6D9H - -
TM1 556 1.50x50 A1 receptor 6D9H A1 receptor 6D9H
TM1 557 1.51x51 A1 receptor 6D9H CB1 receptor 5XRA
TM1 558 1.52x52 A1 receptor 6D9H A1 receptor 6D9H
TM1 559 1.53x53 A1 receptor 6D9H A1 receptor 6D9H
TM1 560 1.54x54 A1 receptor 6D9H A1 receptor 6D9H
TM1 561 1.55x55 A1 receptor 6D9H 5-HT2B receptor 5TUD
TM1 562 1.56x56 A1 receptor 6D9H US28 4XT1
TM1 563 1.57x57 A1 receptor 6D9H Rhodopsin 4ZWJ
TM1 564 1.58x58 A1 receptor 6D9H apelin receptor 5VBL
TM1 565 1.59x59 A1 receptor 6D9H FFA1 receptor 5TZY
TM1 566 1.60x60 A1 receptor 6D9H LPA6 receptor 5XSZ
ICL1 567 - - - -
ICL1 568 AT1 receptor 4ZUD - -
ICL1 569 AT1 receptor 4ZUD - -
ICL1 570 - - - -
TM2 571 2.37x37 A1 receptor 6D9H - -
TM2 572 2.38x38 A1 receptor 6D9H US28 4XT1
TM2 573 2.39x39 A1 receptor 6D9H AT2 receptor 5UNG
TM2 574 2.40x40 A1 receptor 6D9H PAF receptor 5ZKP
TM2 575 2.41x41 A1 receptor 6D9H H1 receptor 3RZE
TM2 576 2.42x42 A1 receptor 6D9H A1 receptor 6D9H
TM2 577 2.43x43 A1 receptor 6D9H A1 receptor 6D9H
TM2 578 2.44x44 A1 receptor 6D9H CB1 receptor 5XRA
TM2 579 2.45x45 A1 receptor 6D9H - -
TM2 580 2.46x46 A1 receptor 6D9H - -
TM2 581 2.47x47 A1 receptor 6D9H OX2 receptor 5WS3
TM2 582 2.48x48 A1 receptor 6D9H A1 receptor 6D9H
TM2 583 2.49x49 A1 receptor 6D9H LPA6 receptor 5XSZ
TM2 584 2.50x50 A1 receptor 6D9H A2A receptor 5WF5
TM2 585 2.51x51 A1 receptor 6D9H AT2 receptor 5UNG
TM2 586 2.52x52 A1 receptor 6D9H Rhodopsin 4ZWJ
TM2 587 2.53x53 A1 receptor 6D9H β2-adrenoceptor 3SN6
TM2 588 2.54x54 A1 receptor 6D9H A1 receptor 6D9H
TM2 589 2.55x55 AT1 receptor 4ZUD 5-HT1B receptor 6G79
TM2 590 2.56x56 AT1 receptor 4ZUD - -
TM2 591 2.57x57 A1 receptor 6D9H - -
TM2 592 2.58x58 A1 receptor 6D9H - -
TM2 593 2.59x59 A1 receptor 6D9H 5-HT2B receptor 5TUD
TM2 594 2.60x60 A1 receptor 6D9H LPA1 receptor 4Z35
TM2 595 2.61x61 A1 receptor 6D9H M2 receptor 4MQT
TM2 596 2.62x62 A1 receptor 6D9H LPA6 receptor 5XSZ
TM2 597 2.63x63 A1 receptor 6D9H D2 receptor 6CM4
TM2 598 2.64x64 A1 receptor 6D9H OX2 receptor 5WS3
TM2 599 2.65x65 A1 receptor 6D9H AT1 receptor 4ZUD
TM2 600 2.66x66 A1 receptor 6D9H CB1 receptor 5XRA
TM2 601 2.67x67 5-HT2C receptor 6BQH FFA1 receptor 5TZR
ECL1 602 - - - -
ECL1 603 - - - -
ECL1 604 - - - -
ECL1 605 - - - -
ECL1 606 - - - -
ECL1 607 - - - -
ECL1 608 - - - -
ECL1 609 - - - -
ECL1 610 - - - -
TM3 611 3.18x18 P2Y12 receptor 4PXZ - -
TM3 612 3.19x19 P2Y12 receptor 4PXZ - -
TM3 613 3.20x20 P2Y12 receptor 4PXZ - -
TM3 614 3.21x21 A1 receptor 6D9H LPA1 receptor 4Z35
TM3 615 3.22x22 A1 receptor 6D9H C5a1 receptor 5O9H
TM3 616 3.23x23 A1 receptor 6D9H LPA1 receptor 4Z35
TM3 617 3.24x24 A1 receptor 6D9H Rhodopsin 4ZWJ
TM3 618 3.25x25 A1 receptor 6D9H A1 receptor 6D9H
TM3 619 3.26x26 A1 receptor 6D9H AT2 receptor 5UNG
TM3 620 3.27x27 A1 receptor 6D9H 5-HT2C receptor 6BQG
TM3 621 3.28x28 A1 receptor 6D9H PAF receptor 5ZKP
TM3 622 3.29x29 A1 receptor 6D9H AT2 receptor 5UNG
TM3 623 3.30x30 A1 receptor 6D9H Rhodopsin 4ZWJ
TM3 624 3.31x31 A1 receptor 6D9H 5-HT2C receptor 6BQG
TM3 625 3.32x32 A1 receptor 6D9H Rhodopsin 4ZWJ
TM3 626 3.33x33 A1 receptor 6D9H 5-HT2C receptor 6BQG
TM3 627 3.34x34 A1 receptor 6D9H AT1 receptor 4ZUD
TM3 628 3.35x35 A1 receptor 6D9H CB1 receptor 5XRA
TM3 629 3.36x36 A1 receptor 6D9H 5-HT2C receptor 6BQG
TM3 630 3.37x37 A1 receptor 6D9H Rhodopsin 4ZWJ
TM3 631 3.38x38 A1 receptor 6D9H A1 receptor 6D9H
TM3 632 3.39x39 A1 receptor 6D9H Rhodopsin 4ZWJ
TM3 633 3.40x40 A1 receptor 6D9H A1 receptor 6D9H
TM3 634 3.41x41 A1 receptor 6D9H AT2 receptor 5UNG
TM3 635 3.42x42 A1 receptor 6D9H AT1 receptor 4ZUD
TM3 636 3.43x43 A1 receptor 6D9H A1 receptor 6D9H
TM3 637 3.44x44 A1 receptor 6D9H CCR9 5LWE
TM3 638 3.45x45 A1 receptor 6D9H CB1 receptor 5XRA
TM3 639 3.46x46 A1 receptor 6D9H CB1 receptor 5XRA
TM3 640 3.47x47 A1 receptor 6D9H PAF receptor 5ZKP
TM3 641 3.48x48 A1 receptor 6D9H A1 receptor 6D9H
TM3 642 3.49x49 A1 receptor 6D9H Rhodopsin 4ZWJ
TM3 643 3.50x50 A1 receptor 6D9H A1 receptor 6D9H
TM3 644 3.51x51 A1 receptor 6D9H BLT1 receptor 5X33
TM3 645 3.52x52 A1 receptor 6D9H A1 receptor 6D9H
TM3 646 3.53x53 A1 receptor 6D9H AT2 receptor 5UNG
TM3 647 3.54x54 A1 receptor 6D9H FFA1 receptor 5TZY
TM3 648 3.55x55 A1 receptor 6D9H A1 receptor 6D9H
TM3 649 3.56x56 A1 receptor 6D9H 5-HT1B receptor 4IAQ
ICL2 650 34.50x50 - - - -
ICL2 651 34.51x51 A1 receptor 5UEN Rhodopsin 4ZWJ
ICL2 652 34.52x52 A1 receptor 5UEN μ receptor 5C1M
ICL2 653 34.53x53 A1 receptor 5UEN Rhodopsin 4ZWJ
ICL2 654 34.54x54 A1 receptor 5UEN - -
ICL2 655 34.55x55 A1 receptor 5UEN BLT1 receptor 5X33
ICL2 656 34.56x56 A1 receptor 5UEN - -
ICL2 657 34.57x57 - - - -
TM4 658 4.38x38 A1 receptor 6D9H - -
TM4 659 4.39x39 A1 receptor 6D9H CCR9 5LWE
TM4 660 4.40x40 A1 receptor 6D9H US28 4XT1
TM4 661 4.41x41 A1 receptor 6D9H AT2 receptor 5UNG
TM4 662 4.42x42 A1 receptor 6D9H - -
TM4 663 4.43x43 A1 receptor 6D9H β2-adrenoceptor 3SN6
TM4 664 4.44x44 A1 receptor 6D9H A1 receptor 6D9H
TM4 665 4.45x45 A1 receptor 6D9H A1 receptor 6D9H
TM4 666 4.46x46 A1 receptor 6D9H - -
TM4 667 4.47x47 A1 receptor 6D9H β2-adrenoceptor 3SN6
TM4 668 4.48x48 A1 receptor 6D9H AT2 receptor 5UNG
TM4 669 4.49x49 A1 receptor 6D9H M2 receptor 4MQT
TM4 670 4.50x50 A1 receptor 6D9H - -
TM4 671 4.51x51 A1 receptor 6D9H κ receptor 6B73
TM4 672 4.52x52 A1 receptor 6D9H - -
TM4 673 4.53x53 A1 receptor 6D9H AT2 receptor 5UNG
TM4 674 4.54x54 A1 receptor 6D9H - -
TM4 675 4.55x55 A1 receptor 6D9H A1 receptor 6D9H
TM4 676 4.56x56 A1 receptor 6D9H PAF receptor 5ZKP
TM4 677 4.57x57 A1 receptor 6D9H A1 receptor 6D9H
TM4 678 4.58x58 A1 receptor 6D9H - -
TM4 679 4.59x59 A1 receptor 6D9H - -
TM4 680 4.60x60 A1 receptor 6D9H A1 receptor 6D9H
TM4 681 4.61x61 A1 receptor 6D9H Rhodopsin 4ZWJ
TM4 682 4.62x62 A1 receptor 6D9H A1 receptor 6D9H
TM4 683 4.63x63 A1 receptor 6D9H - -
TM4 684 4.64x64 AT1 receptor 4ZUD - -
ECL2 685 - - - -
ECL2 686 - - - -
ECL2 687 - - - -
ECL2 688 - - - -
ECL2 689 - - - -
ECL2 690 - - - -
ECL2 691 - - - -
ECL2 692 - - - -
ECL2 693 45.50x50 A1 receptor 6D9H A1 receptor 6D9H
ECL2 694 45.51x51 A1 receptor 6D9H A2A receptor 5G53
ECL2 695 45.52x52 A1 receptor 6D9H - -
ECL2 696 - - - -
ECL2 697 AT2 receptor 5UNG - -
ECL2 698 AT2 receptor 5UNG - -
ECL2 699 AT2 receptor 5UNG - -
ECL2 700 - - - -
TM5 701 5.34x34 AT2 receptor 5UNG - -
TM5 702 5.35x35 AT2 receptor 5UNG PAF receptor 5ZKQ
TM5 703 5.36x36 A1 receptor 6D9H A1 receptor 6D9H
TM5 704 5.37x37 A1 receptor 6D9H κ receptor 6B73
TM5 705 5.38x38 A1 receptor 6D9H AT2 receptor 5UNG
TM5 706 5.39x39 A1 receptor 6D9H 5-HT2C receptor 6BQG
TM5 707 5.40x40 A1 receptor 6D9H M2 receptor 4MQT
TM5 708 5.41x41 AT1 receptor 4ZUD A1 receptor 6D9H
TM5 709 5.42x42 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM5 710 5.43x43 A1 receptor 6D9H US28 4XT1
TM5 711 5.44x44 A1 receptor 6D9H PAF receptor 5ZKP
TM5 712 5.45x45 A1 receptor 6D9H 5-HT2B receptor 5TUD
TM5 713 5.46x46 LPA1 receptor 4Z35 AT2 receptor 5UNG
TM5 714 5.47x47 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM5 715 5.48x48 A1 receptor 6D9H CB1 receptor 5XRA
TM5 716 5.49x49 A1 receptor 6D9H M2 receptor 4MQT
TM5 717 5.50x50 A1 receptor 6D9H - -
TM5 718 5.51x51 A1 receptor 6D9H PAF receptor 5ZKP
TM5 719 5.52x52 A1 receptor 6D9H A1 receptor 6D9H
TM5 720 5.53x53 A1 receptor 6D9H A1 receptor 6D9H
TM5 721 5.54x54 A1 receptor 6D9H A1 receptor 6D9H
TM5 722 5.55x55 A1 receptor 6D9H AT2 receptor 5UNG
TM5 723 5.56x56 A1 receptor 6D9H μ receptor 5C1M
TM5 724 5.57x57 A1 receptor 6D9H A1 receptor 6D9H
TM5 725 5.58x58 A1 receptor 6D9H A1 receptor 6D9H
TM5 726 5.59x59 A1 receptor 6D9H κ receptor 6B73
TM5 727 5.60x60 A1 receptor 6D9H H1 receptor 3RZE
TM5 728 5.61x61 A1 receptor 6D9H Rhodopsin 4ZWJ
TM5 729 5.62x62 A1 receptor 6D9H 5-HT1B receptor 6G79
TM5 730 5.63x63 A1 receptor 6D9H ETB receptor 5X93
TM5 731 5.64x64 A1 receptor 6D9H - -
TM5 732 5.65x65 A1 receptor 6D9H 5-HT2C receptor 6BQG
TM5 733 5.66x66 A1 receptor 6D9H - -
TM5 734 5.67x67 A1 receptor 6D9H A1 receptor 6D9H
ICL3 735 - - - -
ICL3 736 - - - -
ICL3 737 - - - -
ICL3 738 - - - -
ICL3 739 - - - -
TM6 740 6.28x28 A1 receptor 6D9H 5-HT2C receptor 6BQG
TM6 741 6.29x29 A1 receptor 6D9H δ receptor 4N6H
TM6 742 6.30x30 A1 receptor 6D9H - -
TM6 743 6.31x31 A1 receptor 6D9H - -
TM6 744 6.32x32 A1 receptor 6D9H LPA1 receptor 4Z35
TM6 745 6.33x33 A1 receptor 6D9H - -
TM6 746 6.34x34 A1 receptor 6D9H - -
TM6 747 6.35x35 A1 receptor 6D9H A1 receptor 6D9H
TM6 748 6.36x36 A1 receptor 6D9H - -
TM6 749 6.37x37 A1 receptor 6D9H μ receptor 5C1M
TM6 750 6.38x38 A1 receptor 6D9H A1 receptor 6D9H
TM6 751 6.39x39 A1 receptor 6D9H - -
TM6 752 6.40x40 A1 receptor 6D9H apelin receptor 5VBL
TM6 753 6.41x41 A1 receptor 6D9H P2Y12 receptor 4NTJ
TM6 754 6.42x42 A1 receptor 6D9H A1 receptor 6D9H
TM6 755 6.43x43 A1 receptor 6D9H β2-adrenoceptor 3SN6
TM6 756 6.44x44 A1 receptor 6D9H - -
TM6 757 6.45x45 A1 receptor 6D9H LPA6 receptor 5XSZ
TM6 758 6.46x46 A1 receptor 6D9H 5-HT2C receptor 6BQG
TM6 759 6.47x47 A1 receptor 6D9H US28 4XT1
TM6 760 6.48x48 A1 receptor 6D9H PAF receptor 5ZKP
TM6 761 6.49x49 A1 receptor 6D9H 5-HT2C receptor 6BQG
TM6 762 6.50x50 A1 receptor 6D9H A1 receptor 6D9H
TM6 763 6.51x51 A1 receptor 6D9H NOP receptor 5DHG
TM6 764 6.52x52 A1 receptor 6D9H Rhodopsin 4ZWJ
TM6 765 6.53x53 A1 receptor 6D9H P2Y12 receptor 4NTJ
TM6 766 6.54x54 A1 receptor 6D9H κ receptor 6B73
TM6 767 6.55x55 A1 receptor 6D9H 5-HT1B receptor 6G79
TM6 768 6.56x56 A1 receptor 6D9H AT2 receptor 5UNG
TM6 769 6.57x57 A1 receptor 6D9H NOP receptor 5DHG
TM6 770 6.58x58 A1 receptor 6D9H - -
TM6 771 6.59x59 A1 receptor 6D9H A1 receptor 6D9H
TM6 772 6.60x60 A1 receptor 6D9H β2-adrenoceptor 3SN6
TM6 773 6.61x61 A1 receptor 6D9H - -
ECL3 774 - - - -
ECL3 775 A1 receptor 5UEN - -
ECL3 776 A1 receptor 5UEN - -
ECL3 777 A1 receptor 5UEN - -
ECL3 778 - - - -
TM7 779 7.31x30 AT1 receptor 4ZUD M2 receptor 4MQT
TM7 780 7.32x31 A1 receptor 6D9H 5-HT2C receptor 6BQG
TM7 781 7.33x32 A1 receptor 6D9H A1 receptor 6D9H
TM7 782 7.34x33 A1 receptor 6D9H - -
TM7 783 7.35x34 A1 receptor 6D9H P2Y12 receptor 4NTJ
TM7 784 7.36x35 A1 receptor 6D9H D2 receptor 6CM4
TM7 785 7.37x36 A1 receptor 6D9H 5-HT2C receptor 6BQG
TM7 786 7.38x37 A1 receptor 6D9H US28 4XT1
TM7 787 7.39x38 A1 receptor 6D9H PAF receptor 5ZKP
TM7 788 7.40x39 A1 receptor 6D9H FFA1 receptor 5TZY
TM7 789 7.41x40 A1 receptor 6D9H Rhodopsin 4ZWJ
TM7 790 7.42x41 A1 receptor 6D9H NTS1 receptor 4XES
TM7 791 7.43x42 A1 receptor 6D9H - -
TM7 792 7.44x43 A1 receptor 6D9H CB1 receptor 5XRA
TM7 793 7.45x45 A1 receptor 6D9H - -
TM7 794 7.46x46 A1 receptor 6D9H Rhodopsin 4ZWJ
TM7 795 7.47x47 A1 receptor 6D9H AT2 receptor 5UNG
TM7 796 7.48x48 A1 receptor 6D9H μ receptor 5C1M
TM7 797 7.49x49 A1 receptor 6D9H A1 receptor 6D9H
TM7 798 7.50x50 A1 receptor 6D9H A1 receptor 6D9H
TM7 799 7.51x51 A1 receptor 6D9H Rhodopsin 4ZWJ
TM7 800 7.52x52 A1 receptor 6D9H AT2 receptor 5UNG
TM7 801 7.53x53 A1 receptor 6D9H A1 receptor 6D9H
TM7 802 7.54x54 A1 receptor 6D9H US28 4XT1
TM7 803 7.55x55 A1 receptor 6D9H A1 receptor 6D9H
TM7 804 7.56x56 A1 receptor 6D9H 5-HT2C receptor 6BQG
H8 805 8.47x47 A1 receptor 6D9H 5-HT2C receptor 6BQG
H8 806 8.48x48 A1 receptor 6D9H β2-adrenoceptor 3SN6
H8 807 8.49x49 A1 receptor 6D9H A1 receptor 6D9H
H8 808 8.50x50 A1 receptor 6D9H A1 receptor 6D9H
H8 809 8.51x51 A1 receptor 6D9H 5-HT1B receptor 6G79
H8 810 8.52x52 A1 receptor 6D9H OX2 receptor 5WS3
H8 811 8.53x53 A1 receptor 6D9H CCR9 5LWE
H8 812 8.54x54 A1 receptor 6D9H - -
H8 813 8.55x55 A1 receptor 6D9H M2 receptor 4MQT
H8 814 8.56x56 A1 receptor 6D9H M1 receptor 5CXV
H8 815 8.57x57 A1 receptor 5UEN β2-adrenoceptor 3SN6
H8 816 8.58x58 A1 receptor 5UEN - -
H8 817 8.59x59 A1 receptor 5UEN 5-HT2C receptor 6BQG
H8 818 8.60x60 A1 receptor 5UEN - -
H8 819 8.61x61 A1 receptor 5UEN - -
C-term 820 - - - -
C-term 821 - - - -
C-term 822 - - - -
C-term 823 - - - -
C-term 824 - - - -