LGR4 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate (Δ distance (Å): 6.27 docs)

VERSION

2018-07-10

MAIN TEMPLATE

A2A receptor (sequence similarity: 34%) PDB: 4UHR

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 81.4 10.8 7.8
Side-chains 13.2 58.6 28.1

Number of backbone templates: 7
Number of rotamer templates: 36

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4ZUD
4UHR
6BQH
4PXZ
5UEN
5UNG
4Z35
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 531 AT1 receptor 4ZUD AT1 receptor 4ZUD
N-term 532 AT1 receptor 4ZUD AT1 receptor 4ZUD
N-term 533 AT1 receptor 4ZUD AT1 receptor 4ZUD
N-term 534 AT1 receptor 4ZUD AT1 receptor 4ZUD
N-term 535 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM1 536 1.30x30 AT1 receptor 4ZUD PAR2 5NDD
TM1 537 1.31x31 AT1 receptor 4ZUD A2A receptor 5WF5
TM1 538 1.32x32 A2A receptor 4UHR A2A receptor 4UHR
TM1 539 1.33x33 A2A receptor 4UHR OX2 receptor 5WS3
TM1 540 1.34x34 A2A receptor 4UHR AT1 receptor 4ZUD
TM1 541 1.35x35 A2A receptor 4UHR AT1 receptor 4ZUD
TM1 542 1.36x36 A2A receptor 4UHR - -
TM1 543 1.37x37 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM1 544 1.38x38 A2A receptor 4UHR M1 receptor 5CXV
TM1 545 1.39x39 A2A receptor 4UHR - -
TM1 546 1.40x40 A2A receptor 4UHR CCR9 5LWE
TM1 547 1.41x41 A2A receptor 4UHR M3 receptor 4U15
TM1 548 1.42x42 A2A receptor 4UHR A2A receptor 4UHR
TM1 549 1.43x43 A2A receptor 4UHR PAR1 3VW7
TM1 550 1.44x44 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM1 551 1.45x45 A2A receptor 4UHR μ receptor 6DDE
TM1 552 1.46x46 A2A receptor 4UHR A2A receptor 4UHR
TM1 553 1.47x47 A2A receptor 4UHR PAR1 3VW7
TM1 554 1.48x48 A2A receptor 4UHR μ receptor 6DDE
TM1 555 1.49x49 A2A receptor 4UHR - -
TM1 556 1.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM1 557 1.51x51 A2A receptor 4UHR LPA1 receptor 4Z35
TM1 558 1.52x52 A2A receptor 4UHR A2A receptor 4UHR
TM1 559 1.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM1 560 1.54x54 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM1 561 1.55x55 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM1 562 1.56x56 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM1 563 1.57x57 A2A receptor 4UHR Rhodopsin 4ZWJ
TM1 564 1.58x58 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM1 565 1.59x59 A2A receptor 4UHR FFA1 receptor 5TZY
TM1 566 1.60x60 A2A receptor 4UHR apelin receptor 5VBL
ICL1 567 A2A receptor 4UHR - -
ICL1 568 A2A receptor 4UHR - -
ICL1 569 A2A receptor 4UHR - -
ICL1 570 A2A receptor 4UHR - -
TM2 571 2.37x37 A2A receptor 4UHR - -
TM2 572 2.38x38 A2A receptor 4UHR apelin receptor 5VBL
TM2 573 2.39x39 A2A receptor 4UHR FFA1 receptor 5TZY
TM2 574 2.40x40 A2A receptor 4UHR PAF receptor 5ZKQ
TM2 575 2.41x41 A2A receptor 4UHR H1 receptor 3RZE
TM2 576 2.42x42 A2A receptor 4UHR A2A receptor 4UHR
TM2 577 2.43x43 A2A receptor 4UHR μ receptor 6DDE
TM2 578 2.44x44 A2A receptor 4UHR NTS1 receptor 4XES
TM2 579 2.45x45 A2A receptor 4UHR - -
TM2 580 2.46x46 A2A receptor 4UHR - -
TM2 581 2.47x47 A2A receptor 4UHR OX2 receptor 5WS3
TM2 582 2.48x48 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM2 583 2.49x49 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM2 584 2.50x50 A2A receptor 4UHR A2A receptor 5WF5
TM2 585 2.51x51 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM2 586 2.52x52 A2A receptor 4UHR LPA1 receptor 4Z35
TM2 587 2.53x53 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM2 588 2.54x54 A2A receptor 4UHR A2A receptor 4UHR
TM2 589 2.55x55 AT1 receptor 4ZUD 5-HT1B receptor 4IAQ
TM2 590 2.56x56 AT1 receptor 4ZUD - -
TM2 591 2.57x57 A2A receptor 4UHR - -
TM2 592 2.58x58 A2A receptor 4UHR - -
TM2 593 2.59x59 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM2 594 2.60x60 A2A receptor 4UHR P2Y1 receptor 4XNW
TM2 595 2.61x61 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM2 596 2.62x62 A2A receptor 4UHR P2Y1 receptor 4XNW
TM2 597 2.63x63 A2A receptor 4UHR D2 receptor 6CM4
TM2 598 2.64x64 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM2 599 2.65x65 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM2 600 2.66x66 A2A receptor 4UHR D2 receptor 6CM4
TM2 601 2.67x67 5-HT2C receptor 6BQH FFA1 receptor 5TZR
ECL1 602 - - - -
ECL1 603 - - - -
ECL1 604 - - - -
ECL1 605 - - - -
ECL1 606 - - - -
ECL1 607 - - - -
ECL1 608 - - - -
ECL1 609 - - - -
ECL1 610 - - - -
TM3 611 3.18x18 P2Y12 receptor 4PXZ - -
TM3 612 3.19x19 P2Y12 receptor 4PXZ - -
TM3 613 3.20x20 P2Y12 receptor 4PXZ - -
TM3 614 3.21x21 A2A receptor 4UHR LPA1 receptor 4Z35
TM3 615 3.22x22 A2A receptor 4UHR C5a1 receptor 5O9H
TM3 616 3.23x23 A2A receptor 4UHR FFA1 receptor 5TZY
TM3 617 3.24x24 A2A receptor 4UHR A2A receptor 4UHR
TM3 618 3.25x25 A2A receptor 4UHR A2A receptor 4UHR
TM3 619 3.26x26 A2A receptor 4UHR μ receptor 6DDE
TM3 620 3.27x27 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM3 621 3.28x28 A2A receptor 4UHR PAF receptor 5ZKQ
TM3 622 3.29x29 A2A receptor 4UHR PAF receptor 5ZKQ
TM3 623 3.30x30 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM3 624 3.31x31 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM3 625 3.32x32 A2A receptor 4UHR Rhodopsin 4ZWJ
TM3 626 3.33x33 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM3 627 3.34x34 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM3 628 3.35x35 A2A receptor 4UHR LPA1 receptor 4Z35
TM3 629 3.36x36 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM3 630 3.37x37 A2A receptor 4UHR Rhodopsin 4ZWJ
TM3 631 3.38x38 A2A receptor 4UHR A2A receptor 4UHR
TM3 632 3.39x39 A2A receptor 4UHR A2A receptor 5WF6
TM3 633 3.40x40 A2A receptor 4UHR A2A receptor 4UHR
TM3 634 3.41x41 A2A receptor 4UHR A2A receptor 4UHR
TM3 635 3.42x42 A2A receptor 4UHR PAR1 3VW7
TM3 636 3.43x43 A2A receptor 4UHR A2A receptor 4UHR
TM3 637 3.44x44 A2A receptor 4UHR CCR9 5LWE
TM3 638 3.45x45 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM3 639 3.46x46 A2A receptor 4UHR CB1 receptor 5XRA
TM3 640 3.47x47 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM3 641 3.48x48 A2A receptor 4UHR μ receptor 6DDE
TM3 642 3.49x49 A2A receptor 4UHR NTS1 receptor 4XEE
TM3 643 3.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM3 644 3.51x51 A2A receptor 4UHR BLT1 receptor 5X33
TM3 645 3.52x52 A2A receptor 4UHR PAR1 3VW7
TM3 646 3.53x53 A2A receptor 4UHR AT2 receptor 5UNG
TM3 647 3.54x54 A2A receptor 4UHR FFA1 receptor 5TZY
TM3 648 3.55x55 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM3 649 3.56x56 A2A receptor 4UHR 5-HT1B receptor 4IAQ
ICL2 650 34.50x50 - - - -
ICL2 651 34.51x51 A1 receptor 5UEN Rhodopsin 4ZWJ
ICL2 652 34.52x52 A1 receptor 5UEN μ receptor 6DDE
ICL2 653 34.53x53 A1 receptor 5UEN Rhodopsin 4ZWJ
ICL2 654 34.54x54 A1 receptor 5UEN - -
ICL2 655 34.55x55 A1 receptor 5UEN BLT1 receptor 5X33
ICL2 656 34.56x56 A1 receptor 5UEN - -
ICL2 657 34.57x57 - - - -
TM4 658 4.38x38 A2A receptor 4UHR - -
TM4 659 4.39x39 A2A receptor 4UHR PAR1 3VW7
TM4 660 4.40x40 A2A receptor 4UHR 5-HT1B receptor 5V54
TM4 661 4.41x41 A2A receptor 4UHR AT2 receptor 5UNG
TM4 662 4.42x42 A2A receptor 4UHR - -
TM4 663 4.43x43 A2A receptor 4UHR OX2 receptor 5WS3
TM4 664 4.44x44 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM4 665 4.45x45 A2A receptor 4UHR A1 receptor 5UEN
TM4 666 4.46x46 A2A receptor 4UHR - -
TM4 667 4.47x47 A2A receptor 4UHR PAR1 3VW7
TM4 668 4.48x48 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM4 669 4.49x49 A2A receptor 4UHR H1 receptor 3RZE
TM4 670 4.50x50 A2A receptor 4UHR - -
TM4 671 4.51x51 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM4 672 4.52x52 A2A receptor 4UHR - -
TM4 673 4.53x53 A2A receptor 4UHR PAR1 3VW7
TM4 674 4.54x54 A2A receptor 4UHR - -
TM4 675 4.55x55 A2A receptor 4UHR P2Y1 receptor 4XNW
TM4 676 4.56x56 A2A receptor 4UHR P2Y1 receptor 4XNW
TM4 677 4.57x57 A2A receptor 4UHR A2A receptor 4UHR
TM4 678 4.58x58 A2A receptor 4UHR - -
TM4 679 4.59x59 A2A receptor 4UHR - -
TM4 680 4.60x60 A2A receptor 4UHR A2A receptor 4UHR
TM4 681 4.61x61 A2A receptor 4UHR PAR1 3VW7
TM4 682 4.62x62 A2A receptor 4UHR μ receptor 6DDE
TM4 683 4.63x63 A2A receptor 4UHR - -
TM4 684 4.64x64 AT1 receptor 4ZUD - -
ECL2 685 - - - -
ECL2 686 - - - -
ECL2 687 - - - -
ECL2 688 - - - -
ECL2 689 - - - -
ECL2 690 - - - -
ECL2 691 - - - -
ECL2 692 - - - -
ECL2 693 45.50x50 A2A receptor 4UHR A2A receptor 4UHR
ECL2 694 45.51x51 A2A receptor 4UHR A2A receptor 4UHR
ECL2 695 45.52x52 A2A receptor 4UHR - -
ECL2 696 - - - -
ECL2 697 AT2 receptor 5UNG - -
ECL2 698 AT2 receptor 5UNG - -
ECL2 699 AT2 receptor 5UNG - -
ECL2 700 - - - -
TM5 701 5.34x34 AT2 receptor 5UNG - -
TM5 702 5.35x35 AT2 receptor 5UNG PAF receptor 5ZKQ
TM5 703 5.36x36 A2A receptor 4UHR A1 receptor 5UEN
TM5 704 5.37x37 A2A receptor 4UHR PAF receptor 5ZKQ
TM5 705 5.38x38 A2A receptor 4UHR AT1 receptor 4ZUD
TM5 706 5.39x39 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM5 707 5.40x40 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM5 708 5.41x41 AT1 receptor 4ZUD A2A receptor 4UHR
TM5 709 5.42x42 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM5 710 5.43x43 A2A receptor 4UHR PAR2 5NDD
TM5 711 5.44x44 A2A receptor 4UHR PAF receptor 5ZKQ
TM5 712 5.45x45 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM5 713 5.46x46 LPA1 receptor 4Z35 FFA1 receptor 5TZY
TM5 714 5.47x47 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM5 715 5.48x48 A2A receptor 4UHR CB1 receptor 5XRA
TM5 716 5.49x49 A2A receptor 4UHR PAF receptor 5ZKQ
TM5 717 5.50x50 A2A receptor 4UHR - -
TM5 718 5.51x51 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM5 719 5.52x52 A2A receptor 4UHR A2A receptor 4UHR
TM5 720 5.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM5 721 5.54x54 A2A receptor 4UHR A2A receptor 4UHR
TM5 722 5.55x55 A2A receptor 4UHR PAR2 5NDD
TM5 723 5.56x56 A2A receptor 4UHR μ receptor 6DDE
TM5 724 5.57x57 A2A receptor 4UHR A1 receptor 5UEN
TM5 725 5.58x58 A2A receptor 4UHR A2A receptor 4UHR
TM5 726 5.59x59 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM5 727 5.60x60 A2A receptor 4UHR H1 receptor 3RZE
TM5 728 5.61x61 A2A receptor 4UHR Rhodopsin 4ZWJ
TM5 729 5.62x62 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM5 730 5.63x63 A2A receptor 4UHR ETB receptor 5X93
TM5 731 5.64x64 A2A receptor 4UHR - -
TM5 732 5.65x65 A2A receptor 4UHR μ receptor 6DDE
TM5 733 5.66x66 A2A receptor 4UHR - -
TM5 734 5.67x67 A2A receptor 4UHR 5-HT2B receptor 4IB4
ICL3 735 A2A receptor 4UHR - -
ICL3 736 A2A receptor 4UHR - -
ICL3 737 A2A receptor 4UHR - -
ICL3 738 A2A receptor 4UHR - -
ICL3 739 A2A receptor 4UHR - -
TM6 740 6.28x28 A2A receptor 4UHR 5-HT2C receptor 6BQH
TM6 741 6.29x29 A2A receptor 4UHR PAR1 3VW7
TM6 742 6.30x30 A2A receptor 4UHR - -
TM6 743 6.31x31 A2A receptor 4UHR - -
TM6 744 6.32x32 A2A receptor 4UHR PAR1 3VW7
TM6 745 6.33x33 A2A receptor 4UHR - -
TM6 746 6.34x34 A2A receptor 4UHR - -
TM6 747 6.35x35 A2A receptor 4UHR A2A receptor 4UHR
TM6 748 6.36x36 A2A receptor 4UHR - -
TM6 749 6.37x37 A2A receptor 4UHR μ receptor 6DDE
TM6 750 6.38x38 A2A receptor 4UHR A2A receptor 4UHR
TM6 751 6.39x39 A2A receptor 4UHR - -
TM6 752 6.40x40 A2A receptor 4UHR apelin receptor 5VBL
TM6 753 6.41x41 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM6 754 6.42x42 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM6 755 6.43x43 A2A receptor 4UHR P2Y1 receptor 4XNW
TM6 756 6.44x44 A2A receptor 4UHR - -
TM6 757 6.45x45 A2A receptor 4UHR LPA6 receptor 5XSZ
TM6 758 6.46x46 A2A receptor 4UHR PAR1 3VW7
TM6 759 6.47x47 A2A receptor 4UHR CCR5 5UIW
TM6 760 6.48x48 A2A receptor 4UHR PAR1 3VW7
TM6 761 6.49x49 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM6 762 6.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM6 763 6.51x51 A2A receptor 4UHR NOP receptor 5DHG
TM6 764 6.52x52 A2A receptor 4UHR Rhodopsin 4ZWJ
TM6 765 6.53x53 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM6 766 6.54x54 A2A receptor 4UHR AT1 receptor 4ZUD
TM6 767 6.55x55 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM6 768 6.56x56 A2A receptor 4UHR AT1 receptor 4ZUD
TM6 769 6.57x57 A2A receptor 4UHR PAR1 3VW7
TM6 770 6.58x58 A2A receptor 4UHR - -
TM6 771 6.59x59 A2A receptor 4UHR P2Y1 receptor 4XNW
TM6 772 6.60x60 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM6 773 6.61x61 A2A receptor 4UHR - -
ECL3 774 - - - -
ECL3 775 A1 receptor 5UEN - -
ECL3 776 A1 receptor 5UEN - -
ECL3 777 A1 receptor 5UEN - -
ECL3 778 - - - -
TM7 779 7.31x30 A2A receptor 4UHR A2A receptor 4UHR
TM7 780 7.32x31 A2A receptor 4UHR 5-HT2C receptor 6BQH
TM7 781 7.33x32 A2A receptor 4UHR A1 receptor 5UEN
TM7 782 7.34x33 A2A receptor 4UHR - -
TM7 783 7.35x34 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM7 784 7.36x35 A2A receptor 4UHR D2 receptor 6CM4
TM7 785 7.37x36 A2A receptor 4UHR P2Y1 receptor 4XNW
TM7 786 7.38x37 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM7 787 7.39x38 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM7 788 7.40x39 A2A receptor 4UHR FFA1 receptor 5TZY
TM7 789 7.41x40 A2A receptor 4UHR Rhodopsin 4ZWJ
TM7 790 7.42x41 A2A receptor 4UHR NTS1 receptor 4XES
TM7 791 7.43x42 A2A receptor 4UHR - -
TM7 792 7.44x43 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM7 793 7.45x45 A2A receptor 4UHR - -
TM7 794 7.46x46 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM7 795 7.47x47 A2A receptor 4UHR μ receptor 6DDE
TM7 796 7.48x48 A2A receptor 4UHR μ receptor 6DDE
TM7 797 7.49x49 A2A receptor 4UHR A2A receptor 4UHR
TM7 798 7.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM7 799 7.51x51 A2A receptor 4UHR μ receptor 6DDE
TM7 800 7.52x52 A2A receptor 4UHR μ receptor 6DDE
TM7 801 7.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM7 802 7.54x54 A2A receptor 4UHR C5a1 receptor 5O9H
TM7 803 7.55x55 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM7 804 7.56x56 A2A receptor 4UHR 5-HT2B receptor 4IB4
H8 805 8.47x47 A2A receptor 4UHR 5-HT2B receptor 4IB4
H8 806 8.48x48 A2A receptor 4UHR apelin receptor 5VBL
H8 807 8.49x49 A2A receptor 4UHR A1 receptor 5UEN
H8 808 8.50x50 A2A receptor 4UHR A2A receptor 4UHR
H8 809 8.51x51 A2A receptor 4UHR 5-HT1B receptor 4IAQ
H8 810 8.52x52 A2A receptor 4UHR OX2 receptor 5WS3
H8 811 8.53x53 A2A receptor 4UHR CCR9 5LWE
H8 812 8.54x54 A2A receptor 4UHR - -
H8 813 8.55x55 A2A receptor 4UHR PAR2 5NDD
H8 814 8.56x56 A2A receptor 4UHR M1 receptor 5CXV
H8 815 8.57x57 A2A receptor 4UHR 5-HT1B receptor 4IAQ
H8 816 8.58x58 A2A receptor 4UHR - -
H8 817 8.59x59 A2A receptor 4UHR A2A receptor 4UHR
H8 818 8.60x60 A2A receptor 4UHR - -
H8 819 8.61x61 A2A receptor 4UHR - -
C-term 820 A2A receptor 4UHR A2A receptor 4UHR
C-term 821 A2A receptor 4UHR A2A receptor 4UHR
C-term 822 A2A receptor 4UHR A2A receptor 4UHR
C-term 823 A2A receptor 4UHR A2A receptor 4UHR
C-term 824 A2A receptor 4UHR A2A receptor 4UHR
C-term 825 A2A receptor 4UHR A2A receptor 4UHR