LGR5 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 9.68 docs)

VERSION

2018-07-10

MAIN TEMPLATE

A2A receptor (sequence similarity: 36%) PDB: 5G53

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 74.8 13.8 11.5
Side-chains 15.7 49.5 34.8

Number of backbone templates: 12
Number of rotamer templates: 35

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3P0G
3SN6
5G53
4UHR
2YDV
4ZUD
6CM4
4PXZ
6B73
5WS3
3V2Y
5UEN
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 547 - - - -
N-term 548 - - - -
N-term 549 - - - -
N-term 550 - - - -
N-term 551 - - - -
TM1 552 1.27x27 β2-adrenoceptor 3P0G - -
TM1 553 1.28x28 β2-adrenoceptor 3P0G - -
TM1 554 1.29x29 β2-adrenoceptor 3P0G 5-HT1B receptor 6G79
TM1 555 1.30x30 β2-adrenoceptor 3P0G PAR2 5NDD
TM1 556 1.31x31 β2-adrenoceptor 3P0G - -
TM1 557 1.32x32 A2A receptor 5G53 - -
TM1 558 1.33x33 A2A receptor 5G53 OX2 receptor 5WS3
TM1 559 1.34x34 A2A receptor 5G53 5-HT1B receptor 6G79
TM1 560 1.35x35 A2A receptor 5G53 AT2 receptor 5UNG
TM1 561 1.36x36 A2A receptor 5G53 - -
TM1 562 1.37x37 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM1 563 1.38x38 A2A receptor 5G53 D4 receptor 5WIV
TM1 564 1.39x39 A2A receptor 5G53 - -
TM1 565 1.40x40 A2A receptor 5G53 CCR9 5LWE
TM1 566 1.41x41 A2A receptor 5G53 CB1 receptor 5XRA
TM1 567 1.42x42 A2A receptor 5G53 A2A receptor 5G53
TM1 568 1.43x43 A2A receptor 5G53 A2A receptor 5G53
TM1 569 1.44x44 A2A receptor 5G53 A2A receptor 5G53
TM1 570 1.45x45 A2A receptor 5G53 A2A receptor 5G53
TM1 571 1.46x46 A2A receptor 5G53 A2A receptor 5G53
TM1 572 1.47x47 A2A receptor 5G53 κ receptor 6B73
TM1 573 1.48x48 A2A receptor 5G53 apelin receptor 5VBL
TM1 574 1.49x49 A2A receptor 5G53 - -
TM1 575 1.50x50 A2A receptor 5G53 A2A receptor 5G53
TM1 576 1.51x51 A2A receptor 5G53 5-HT1B receptor 6G79
TM1 577 1.52x52 A2A receptor 5G53 A2A receptor 5G53
TM1 578 1.53x53 A2A receptor 5G53 A2A receptor 5G53
TM1 579 1.54x54 A2A receptor 5G53 - -
TM1 580 1.55x55 A2A receptor 5G53 - -
TM1 581 1.56x56 A2A receptor 5G53 5-HT1B receptor 6G79
TM1 582 1.57x57 A2A receptor 5G53 A2A receptor 5G53
TM1 583 1.58x58 A2A receptor 5G53 apelin receptor 5VBL
TM1 584 1.59x59 A2A receptor 5G53 μ receptor 5C1M
TM1 585 1.60x60 A2A receptor 5G53 LPA6 receptor 5XSZ
ICL1 586 A2A receptor 5G53 - -
ICL1 587 A2A receptor 5G53 - -
ICL1 588 A2A receptor 5G53 - -
ICL1 589 A2A receptor 5G53 - -
TM2 590 2.37x37 A2A receptor 5G53 CCR5 5UIW
TM2 591 2.38x38 A2A receptor 5G53 Rhodopsin 5DYS
TM2 592 2.39x39 A2A receptor 5G53 PAF receptor 5ZKP
TM2 593 2.40x40 A2A receptor 5G53 PAF receptor 5ZKP
TM2 594 2.41x41 A2A receptor 5G53 H1 receptor 3RZE
TM2 595 2.42x42 A2A receptor 5G53 5-HT1B receptor 6G79
TM2 596 2.43x43 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM2 597 2.44x44 A2A receptor 5G53 CB1 receptor 5XRA
TM2 598 2.45x45 A2A receptor 5G53 - -
TM2 599 2.46x46 A2A receptor 5G53 - -
TM2 600 2.47x47 A2A receptor 5G53 A2A receptor 5G53
TM2 601 2.48x48 A2A receptor 5G53 A2A receptor 5G53
TM2 602 2.49x49 A2A receptor 5G53 - -
TM2 603 2.50x50 A2A receptor 5G53 A2A receptor 5WF5
TM2 604 2.51x51 A2A receptor 5G53 5-HT2C receptor 6BQG
TM2 605 2.52x52 A2A receptor 5G53 5-HT1B receptor 6G79
TM2 606 2.53x53 A2A receptor 5G53 - -
TM2 607 2.54x54 A2A receptor 5G53 A2A receptor 5G53
TM2 608 2.55x55 AT1 receptor 4ZUD A2A receptor 5G53
TM2 609 2.56x56 AT1 receptor 4ZUD M2 receptor 4MQT
TM2 610 2.57x57 A2A receptor 5G53 - -
TM2 611 2.58x58 A2A receptor 5G53 - -
TM2 612 2.59x59 A2A receptor 5G53 NTS1 receptor 5T04
TM2 613 2.60x60 A2A receptor 5G53 LPA1 receptor 4Z35
TM2 614 2.61x61 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM2 615 2.62x62 A2A receptor 5G53 - -
TM2 616 2.63x63 A2A receptor 5G53 κ receptor 6B73
TM2 617 2.64x64 A2A receptor 5G53 OX2 receptor 5WS3
TM2 618 2.65x65 A2A receptor 5G53 AT1 receptor 4ZUD
TM2 619 2.66x66 A2A receptor 5G53 5-HT2B receptor 5TUD
TM2 620 2.67x67 D2 receptor 6CM4 - -
ECL1 621 - - - -
ECL1 622 - - - -
ECL1 623 - - - -
ECL1 624 - - - -
ECL1 625 - - - -
ECL1 626 - - - -
ECL1 627 - - - -
ECL1 628 - - - -
ECL1 629 - - - -
TM3 630 3.18x18 P2Y12 receptor 4PXZ - -
TM3 631 3.19x19 P2Y12 receptor 4PXZ - -
TM3 632 3.20x20 P2Y12 receptor 4PXZ - -
TM3 633 3.21x21 A2A receptor 5G53 - -
TM3 634 3.22x22 A2A receptor 5G53 C5a1 receptor 5O9H
TM3 635 3.23x23 A2A receptor 5G53 AT2 receptor 5UNG
TM3 636 3.24x24 A2A receptor 5G53 A2A receptor 5G53
TM3 637 3.25x25 A2A receptor 5G53 A2A receptor 5G53
TM3 638 3.26x26 A2A receptor 5G53 - -
TM3 639 3.27x27 A2A receptor 5G53 5-HT2C receptor 6BQG
TM3 640 3.28x28 A2A receptor 5G53 A2A receptor 5G53
TM3 641 3.29x29 A2A receptor 5G53 Rhodopsin 5DYS
TM3 642 3.30x30 A2A receptor 5G53 Rhodopsin 5DYS
TM3 643 3.31x31 A2A receptor 5G53 5-HT2C receptor 6BQG
TM3 644 3.32x32 A2A receptor 5G53 - -
TM3 645 3.33x33 A2A receptor 5G53 5-HT1B receptor 6G79
TM3 646 3.34x34 A2A receptor 5G53 AT1 receptor 4ZUD
TM3 647 3.35x35 A2A receptor 5G53 US28 4XT1
TM3 648 3.36x36 A2A receptor 5G53 5-HT2C receptor 6BQG
TM3 649 3.37x37 A2A receptor 5G53 Rhodopsin 5DYS
TM3 650 3.38x38 A2A receptor 5G53 A2A receptor 5G53
TM3 651 3.39x39 A2A receptor 5G53 A2A receptor 5G53
TM3 652 3.40x40 A2A receptor 5G53 CB1 receptor 5XRA
TM3 653 3.41x41 A2A receptor 5G53 A2A receptor 5G53
TM3 654 3.42x42 A2A receptor 5G53 AT1 receptor 4ZUD
TM3 655 3.43x43 A2A receptor 5G53 A2A receptor 5G53
TM3 656 3.44x44 A2A receptor 5G53 AT2 receptor 5UNG
TM3 657 3.45x45 A2A receptor 5G53 CB1 receptor 5XRA
TM3 658 3.46x46 A2A receptor 5G53 CB1 receptor 5XRA
TM3 659 3.47x47 A2A receptor 5G53 A2A receptor 5G53
TM3 660 3.48x48 A2A receptor 5G53 5-HT1B receptor 6G79
TM3 661 3.49x49 A2A receptor 5G53 Rhodopsin 5DYS
TM3 662 3.50x50 A2A receptor 5G53 A2A receptor 5G53
TM3 663 3.51x51 A2A receptor 5G53 - -
TM3 664 3.52x52 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM3 665 3.53x53 A2A receptor 5G53 AT2 receptor 5UNG
TM3 666 3.54x54 A2A receptor 5G53 A1 receptor 6D9H
TM3 667 3.55x55 A2A receptor 5G53 A1 receptor 6D9H
TM3 668 3.56x56 A2A receptor 5G53 AT2 receptor 5UNG
ICL2 669 34.50x50 - - - -
ICL2 670 34.51x51 A2A receptor 4UHR C5a1 receptor 5O9H
ICL2 671 34.52x52 A2A receptor 4UHR β2-adrenoceptor 3SN6
ICL2 672 34.53x53 A2A receptor 4UHR - -
ICL2 673 34.54x54 A2A receptor 4UHR - -
ICL2 674 34.55x55 A2A receptor 4UHR NTS1 receptor 5T04
ICL2 675 34.56x56 A2A receptor 4UHR 5-HT1B receptor 6G79
ICL2 676 34.57x57 - - - -
TM4 677 4.38x38 A2A receptor 5G53 US28 4XT1
TM4 678 4.39x39 A2A receptor 5G53 - -
TM4 679 4.40x40 A2A receptor 5G53 NTS1 receptor 5T04
TM4 680 4.41x41 A2A receptor 5G53 apelin receptor 5VBL
TM4 681 4.42x42 A2A receptor 5G53 S1P1 receptor 3V2Y
TM4 682 4.43x43 A2A receptor 5G53 A2A receptor 5G53
TM4 683 4.44x44 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM4 684 4.45x45 A2A receptor 5G53 A2A receptor 5G53
TM4 685 4.46x46 A2A receptor 5G53 A2A receptor 5G53
TM4 686 4.47x47 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM4 687 4.48x48 A2A receptor 5G53 5-HT1B receptor 6G79
TM4 688 4.49x49 A2A receptor 5G53 A2A receptor 5G53
TM4 689 4.50x50 A2A receptor 5G53 - -
TM4 690 4.51x51 A2A receptor 5G53 5-HT2B receptor 5TUD
TM4 691 4.52x52 A2A receptor 5G53 A2A receptor 5G53
TM4 692 4.53x53 A2A receptor 5G53 Rhodopsin 5DYS
TM4 693 4.54x54 A2A receptor 5G53 Rhodopsin 5DYS
TM4 694 4.55x55 A2A receptor 5G53 D2 receptor 6CM4
TM4 695 4.56x56 A2A receptor 5G53 LPA1 receptor 4Z35
TM4 696 4.57x57 A2A receptor 5G53 Rhodopsin 5DYS
TM4 697 4.58x58 A2A receptor 5G53 Rhodopsin 5DYS
TM4 698 4.59x59 A2A receptor 5G53 5-HT2C receptor 6BQG
TM4 699 4.60x60 A2A receptor 5G53 A2A receptor 5G53
TM4 700 4.61x61 A2A receptor 5G53 Rhodopsin 5DYS
TM4 701 4.62x62 A2A receptor 5G53 A2A receptor 5G53
TM4 702 4.63x63 A2A receptor 5G53 A2A receptor 5G53
ECL2 703 - - - -
ECL2 704 κ receptor 6B73 - -
ECL2 705 κ receptor 6B73 - -
ECL2 706 κ receptor 6B73 - -
ECL2 707 κ receptor 6B73 - -
ECL2 708 - - - -
ECL2 709 - - - -
ECL2 710 - - - -
ECL2 711 - - - -
ECL2 712 45.50x50 A2A receptor 5G53 A2A receptor 5G53
ECL2 713 45.51x51 A2A receptor 5G53 A2A receptor 5G53
ECL2 714 45.52x52 A2A receptor 5G53 - -
ECL2 715 - - - -
ECL2 716 OX2 receptor 5WS3 - -
ECL2 717 OX2 receptor 5WS3 - -
ECL2 718 OX2 receptor 5WS3 OX2 receptor 5WS3
ECL2 719 - - - -
TM5 720 5.34x34 OX2 receptor 5WS3 - -
TM5 721 5.35x35 OX2 receptor 5WS3 P2Y1 receptor 4XNW
TM5 722 5.36x36 A2A receptor 5G53 - -
TM5 723 5.37x37 A2A receptor 5G53 A2A receptor 5G53
TM5 724 5.38x38 A2A receptor 5G53 AT2 receptor 5UNG
TM5 725 5.39x39 A2A receptor 5G53 A2A receptor 5G53
TM5 726 5.40x40 A2A receptor 5G53 A2A receptor 5G53
TM5 727 5.41x41 β2-adrenoceptor 3SN6 A2A receptor 5G53
TM5 728 5.42x42 β2-adrenoceptor 3SN6 β2-adrenoceptor 3SN6
TM5 729 5.43x43 A2A receptor 5G53 US28 4XT1
TM5 730 5.44x44 A2A receptor 5G53 CB1 receptor 5XRA
TM5 731 5.45x45 A2A receptor 5G53 5-HT2B receptor 5TUD
TM5 732 5.46x46 S1P1 receptor 3V2Y AT2 receptor 5UNG
TM5 733 5.47x47 S1P1 receptor 3V2Y LPA1 receptor 4Z35
TM5 734 5.48x48 A2A receptor 5G53 CB1 receptor 5XRA
TM5 735 5.49x49 A2A receptor 5G53 M2 receptor 4MQT
TM5 736 5.50x50 A2A receptor 5G53 - -
TM5 737 5.51x51 A2A receptor 5G53 PAF receptor 5ZKP
TM5 738 5.52x52 A2A receptor 5G53 A2A receptor 5G53
TM5 739 5.53x53 A2A receptor 5G53 - -
TM5 740 5.54x54 A2A receptor 5G53 A2A receptor 5G53
TM5 741 5.55x55 A2A receptor 5G53 μ receptor 5C1M
TM5 742 5.56x56 A2A receptor 5G53 5-HT2C receptor 6BQG
TM5 743 5.57x57 A2A receptor 5G53 CB1 receptor 5XRA
TM5 744 5.58x58 A2A receptor 5G53 A2A receptor 5G53
TM5 745 5.59x59 A2A receptor 5G53 κ receptor 6B73
TM5 746 5.60x60 A2A receptor 5G53 H1 receptor 3RZE
TM5 747 5.61x61 A2A receptor 5G53 Rhodopsin 5DYS
TM5 748 5.62x62 A2A receptor 5G53 5-HT1B receptor 6G79
TM5 749 5.63x63 A2A receptor 5G53 ETB receptor 5X93
TM5 750 5.64x64 A2A receptor 5G53 - -
TM5 751 5.65x65 A2A receptor 5G53 5-HT2C receptor 6BQG
TM5 752 5.66x66 A2A receptor 5G53 - -
TM5 753 5.67x67 A2A receptor 5G53 A1 receptor 6D9H
ICL3 754 - - - -
ICL3 755 - - - -
ICL3 756 - - - -
ICL3 757 - - - -
ICL3 758 - - - -
TM6 759 6.28x28 A2A receptor 5G53 AT2 receptor 5UNG
TM6 760 6.29x29 A2A receptor 5G53 - -
TM6 761 6.30x30 A2A receptor 5G53 CB1 receptor 5XRA
TM6 762 6.31x31 A2A receptor 5G53 - -
TM6 763 6.32x32 A2A receptor 5G53 LPA1 receptor 4Z35
TM6 764 6.33x33 A2A receptor 5G53 - -
TM6 765 6.34x34 A2A receptor 5G53 US28 4XT1
TM6 766 6.35x35 A2A receptor 5G53 A2A receptor 5G53
TM6 767 6.36x36 A2A receptor 5G53 - -
TM6 768 6.37x37 A2A receptor 5G53 M2 receptor 4MQT
TM6 769 6.38x38 A2A receptor 5G53 A2A receptor 5G53
TM6 770 6.39x39 A2A receptor 5G53 A1 receptor 6D9H
TM6 771 6.40x40 A2A receptor 5G53 apelin receptor 5VBL
TM6 772 6.41x41 A2A receptor 5G53 A1 receptor 6D9H
TM6 773 6.42x42 A2A receptor 5G53 A1 receptor 6D9H
TM6 774 6.43x43 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM6 775 6.44x44 A2A receptor 5G53 - -
TM6 776 6.45x45 A2A receptor 5G53 LPA6 receptor 5XSZ
TM6 777 6.46x46 A2A receptor 5G53 Rhodopsin 5DYS
TM6 778 6.47x47 A2A receptor 5G53 - -
TM6 779 6.48x48 A2A receptor 5G53 - -
TM6 780 6.49x49 A2A receptor 5G53 5-HT2C receptor 6BQG
TM6 781 6.50x50 A2A receptor 5G53 A2A receptor 5G53
TM6 782 6.51x51 A2A receptor 5G53 NOP receptor 5DHG
TM6 783 6.52x52 A2A receptor 5G53 Rhodopsin 5DYS
TM6 784 6.53x53 A2A receptor 5G53 P2Y12 receptor 4NTJ
TM6 785 6.54x54 A2A receptor 5G53 A1 receptor 6D9H
TM6 786 6.55x55 A2A receptor 5G53 5-HT1B receptor 6G79
TM6 787 6.56x56 A2A receptor 5G53 Rhodopsin 5DYS
TM6 788 6.57x57 A2A receptor 5G53 - -
TM6 789 6.58x58 A2A receptor 5G53 5-HT2C receptor 6BQG
TM6 790 6.59x59 A2A receptor 5G53 A1 receptor 6D9H
TM6 791 6.60x60 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM6 792 6.61x61 A2A receptor 5G53 Y1 receptor 5ZBH
ECL3 793 - - - -
ECL3 794 A1 receptor 5UEN - -
ECL3 795 A1 receptor 5UEN - -
ECL3 796 A1 receptor 5UEN - -
ECL3 797 - - - -
TM7 798 7.31x30 A2A receptor 5G53 A2A receptor 5G53
TM7 799 7.32x31 A2A receptor 5G53 5-HT2C receptor 6BQG
TM7 800 7.33x32 A2A receptor 5G53 μ receptor 5C1M
TM7 801 7.34x33 A2A receptor 5G53 5-HT1B receptor 6G79
TM7 802 7.35x34 A2A receptor 5G53 P2Y12 receptor 4NTJ
TM7 803 7.36x35 A2A receptor 5G53 - -
TM7 804 7.37x36 A2A receptor 5G53 A1 receptor 6D9H
TM7 805 7.38x37 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM7 806 7.39x38 A2A receptor 5G53 PAF receptor 5ZKP
TM7 807 7.40x39 A2A receptor 5G53 A2A receptor 5G53
TM7 808 7.41x40 A2A receptor 5G53 PAR1 3VW7
TM7 809 7.42x41 A2A receptor 5G53 OX2 receptor 5WS3
TM7 810 7.43x42 A2A receptor 5G53 - -
TM7 811 7.44x43 A2A receptor 5G53 CB1 receptor 5XRA
TM7 812 7.45x45 A2A receptor 5G53 - -
TM7 813 7.46x46 A2A receptor 5G53 Rhodopsin 5DYS
TM7 814 7.47x47 A2A receptor 5G53 AT2 receptor 5UNG
TM7 815 7.48x48 A2A receptor 5G53 κ receptor 6B73
TM7 816 7.49x49 A2A receptor 5G53 A2A receptor 5G53
TM7 817 7.50x50 A2A receptor 5G53 A2A receptor 5G53
TM7 818 7.51x51 A2A receptor 5G53 β2-adrenoceptor 3SN6
TM7 819 7.52x52 A2A receptor 5G53 AT2 receptor 5UNG
TM7 820 7.53x53 A2A receptor 5G53 A2A receptor 5G53
TM7 821 7.54x54 A2A receptor 5G53 Rhodopsin 5DYS
TM7 822 7.55x55 A2A receptor 5G53 5-HT2C receptor 6BQG
TM7 823 7.56x56 A2A receptor 5G53 5-HT2C receptor 6BQG
H8 824 8.47x47 A2A receptor 5G53 Rhodopsin 5DYS
H8 825 8.48x48 A2A receptor 5G53 β2-adrenoceptor 3SN6
H8 826 8.49x49 A2A receptor 5G53 - -
H8 827 8.50x50 A2A receptor 5G53 A2A receptor 5G53
H8 828 8.51x51 A2A receptor 5G53 5-HT1B receptor 6G79
H8 829 8.52x52 A2A receptor 5G53 OX2 receptor 5WS3
H8 830 8.53x53 A2A receptor 5G53 CCR9 5LWE
H8 831 8.54x54 A2A receptor 5G53 AT2 receptor 5UNG
H8 832 8.55x55 A2A receptor 5G53 Rhodopsin 5DYS
H8 833 8.56x56 A2A receptor 5G53 AT2 receptor 5UNG
H8 834 8.57x57 A2A receptor 5G53 β2-adrenoceptor 3SN6
H8 835 8.58x58 A2A receptor 5G53 - -
H8 836 8.59x59 A2A receptor 5G53 CCR9 5LWE
H8 837 8.60x60 A2A receptor 5G53 - -
H8 838 8.61x61 A2A receptor 2YDV - -
H8 839 8.62x62 A2A receptor 2YDV - -
H8 840 8.63x63 A2A receptor 2YDV - -
H8 841 8.64x64 A2A receptor 2YDV - -
H8 842 8.65x65 A2A receptor 2YDV - -
H8 843 8.66x66 A2A receptor 2YDV - -
H8 844 8.67x67 A2A receptor 2YDV - -
H8 845 8.68x68 A2A receptor 2YDV - -
H8 846 8.69x69 A2A receptor 2YDV - -
C-term 847 - - - -
C-term 848 - - - -
C-term 849 - - - -
C-term 850 - - - -
C-term 851 - - - -