LPA5 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate (Δ distance (Å): 7.11 docs)

VERSION

2018-07-10

MAIN TEMPLATE

PAR2 (sequence similarity: 45%) PDB: 5NDD

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 79.5 13.6 6.8
Side-chains 25.6 50.3 24.0

Number of backbone templates: 7
Number of rotamer templates: 33

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5NDD
4ZUD
5XSZ
4XES
6B73
3ODU
4XT1
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 13 PAR2 5NDD PAR2 5NDD
N-term 14 PAR2 5NDD PAR2 5NDD
N-term 15 PAR2 5NDD PAR2 5NDD
N-term 16 PAR2 5NDD PAR2 5NDD
N-term 17 PAR2 5NDD PAR2 5NDD
TM1 18 1.28x28 PAR2 5NDD - -
TM1 19 1.29x29 PAR2 5NDD - -
TM1 20 1.30x30 PAR2 5NDD 5-HT1B receptor 4IAQ
TM1 21 1.31x31 PAR2 5NDD PAR2 5NDD
TM1 22 1.32x32 PAR2 5NDD - -
TM1 23 1.33x33 PAR2 5NDD CCR5 5UIW
TM1 24 1.34x34 PAR2 5NDD P2Y12 receptor 4NTJ
TM1 25 1.35x35 PAR2 5NDD - -
TM1 26 1.36x36 PAR2 5NDD C5a1 receptor 5O9H
TM1 27 1.37x37 PAR2 5NDD C5a1 receptor 5O9H
TM1 28 1.38x38 PAR2 5NDD PAR2 5NDD
TM1 29 1.39x39 PAR2 5NDD PAR2 5NDD
TM1 30 1.40x40 PAR2 5NDD μ receptor 6DDE
TM1 31 1.41x41 PAR2 5NDD P2Y1 receptor 4XNW
TM1 32 1.42x42 PAR2 5NDD PAR2 5NDD
TM1 33 1.43x43 PAR2 5NDD - -
TM1 34 1.44x44 PAR2 5NDD FFA1 receptor 5TZY
TM1 35 1.45x45 PAR2 5NDD 5-HT1B receptor 4IAQ
TM1 36 1.46x46 PAR2 5NDD μ receptor 6DDE
TM1 37 1.47x47 PAR2 5NDD PAR2 5NDD
TM1 38 1.48x48 PAR2 5NDD PAR2 5NDD
TM1 39 1.49x49 PAR2 5NDD PAR1 3VW7
TM1 40 1.50x50 PAR2 5NDD PAR2 5NDD
TM1 41 1.51x51 PAR2 5NDD 5-HT1B receptor 4IAQ
TM1 42 1.52x52 PAR2 5NDD μ receptor 6DDE
TM1 43 1.53x53 PAR2 5NDD PAR2 5NDD
TM1 44 1.54x54 PAR2 5NDD PAR2 5NDD
TM1 45 1.55x55 PAR2 5NDD PAR2 5NDD
TM1 46 1.56x56 PAR2 5NDD PAR2 5NDD
TM1 47 1.57x57 PAR2 5NDD PAR2 5NDD
TM1 48 1.58x58 PAR2 5NDD PAR2 5NDD
TM1 49 1.59x59 PAR2 5NDD NTS1 receptor 4XES
TM1 50 1.60x60 PAR2 5NDD - -
ICL1 51 12.48x48 - - - -
ICL1 52 12.49x49 AT1 receptor 4ZUD β2-adrenoceptor 5JQH
ICL1 53 12.50x50 AT1 receptor 4ZUD - -
ICL1 54 12.51x51 - - - -
TM2 55 2.37x37 PAR2 5NDD P2Y1 receptor 4XNW
TM2 56 2.38x38 PAR2 5NDD A2A receptor 4UHR
TM2 57 2.39x39 PAR2 5NDD NTS1 receptor 4XES
TM2 58 2.40x40 PAR2 5NDD P2Y1 receptor 4XNW
TM2 59 2.41x41 PAR2 5NDD PAR1 3VW7
TM2 60 2.42x42 PAR2 5NDD PAR2 5NDD
TM2 61 2.43x43 PAR2 5NDD PAR2 5NDD
TM2 62 2.44x44 PAR2 5NDD - -
TM2 63 2.45x45 PAR2 5NDD PAR2 5NDD
TM2 64 2.46x46 PAR2 5NDD PAR2 5NDD
TM2 65 2.47x47 PAR2 5NDD PAR2 5NDD
TM2 66 2.48x48 PAR2 5NDD A2A receptor 4UHR
TM2 67 2.49x49 PAR2 5NDD P2Y12 receptor 4NTJ
TM2 68 2.50x50 PAR2 5NDD PAR2 5NDD
TM2 69 2.51x51 PAR2 5NDD PAR2 5NDD
TM2 70 2.52x52 PAR2 5NDD PAR2 5NDD
TM2 71 2.53x53 PAR2 5NDD PAR1 3VW7
TM2 72 2.54x54 PAR2 5NDD FFA1 receptor 5TZY
TM2 73 2.55x55 PAR2 5NDD P2Y1 receptor 4XNW
TM2 74 2.56x56 PAR2 5NDD FFA1 receptor 5TZY
TM2 75 2.57x57 PAR2 5NDD μ receptor 6DDE
TM2 76 2.58x58 PAR2 5NDD PAR2 5NDD
TM2 77 2.59x59 PAR2 5NDD NTS1 receptor 4XES
TM2 78 2.60x60 PAR2 5NDD LPA6 receptor 5XSZ
TM2 79 2.61x61 PAR2 5NDD NTS1 receptor 4XES
TM2 80 2.62x62 PAR2 5NDD PAR1 3VW7
TM2 81 2.63x63 PAR2 5NDD PAR2 5NDD
TM2 82 2.64x64 PAR2 5NDD μ receptor 6DDE
TM2 83 2.65x65 PAR2 5NDD P2Y12 receptor 4NTJ
TM2 84 2.66x66 PAR2 5NDD NOP receptor 5DHG
ECL1 85 - - - -
ECL1 86 23.49x49 LPA6 receptor 5XSZ C5a1 receptor 5O9H
ECL1 87 23.50x50 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
ECL1 88 23.51x51 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
ECL1 89 23.52x52 - - - -
TM3 90 3.21x21 PAR2 5NDD PAF receptor 5ZKQ
TM3 91 3.22x22 PAR2 5NDD P2Y1 receptor 4XNW
TM3 92 3.23x23 PAR2 5NDD δ receptor 4N6H
TM3 93 3.24x24 PAR2 5NDD PAR2 5NDD
TM3 94 3.25x25 PAR2 5NDD PAR2 5NDD
TM3 95 3.26x26 PAR2 5NDD P2Y12 receptor 4NTJ
TM3 96 3.27x27 PAR2 5NDD NOP receptor 5DHG
TM3 97 3.28x28 PAR2 5NDD P2Y12 receptor 4NTJ
TM3 98 3.29x29 PAR2 5NDD PAF receptor 5ZKQ
TM3 99 3.30x30 PAR2 5NDD PAR1 3VW7
TM3 100 3.31x31 PAR2 5NDD μ receptor 6DDE
TM3 101 3.32x32 PAR2 5NDD PAR2 5NDD
TM3 102 3.33x33 PAR2 5NDD - -
TM3 103 3.34x34 PAR2 5NDD CCR9 5LWE
TM3 104 3.35x35 PAR2 5NDD PAR2 5NDD
TM3 105 3.36x36 PAR2 5NDD PAR2 5NDD
TM3 106 3.37x37 PAR2 5NDD PAR2 5NDD
TM3 107 3.38x38 PAR2 5NDD P2Y1 receptor 4XNW
TM3 108 3.39x39 PAR2 5NDD PAR2 5NDD
TM3 109 3.40x40 PAR2 5NDD - -
TM3 110 3.41x41 PAR2 5NDD - -
TM3 111 3.42x42 PAR2 5NDD PAR2 5NDD
TM3 112 3.43x43 PAR2 5NDD PAR2 5NDD
TM3 113 3.44x44 PAR2 5NDD CCR9 5LWE
TM3 114 3.45x45 PAR2 5NDD P2Y12 receptor 4NTJ
TM3 115 3.46x46 PAR2 5NDD PAR1 3VW7
TM3 116 3.47x47 PAR2 5NDD - -
TM3 117 3.48x48 PAR2 5NDD PAR2 5NDD
TM3 118 3.49x49 PAR2 5NDD μ receptor 6DDE
TM3 119 3.50x50 PAR2 5NDD PAR2 5NDD
TM3 120 3.51x51 PAR2 5NDD μ receptor 6DDE
TM3 121 3.52x52 PAR2 5NDD - -
TM3 122 3.53x53 PAR2 5NDD μ receptor 6DDE
TM3 123 3.54x54 PAR2 5NDD PAR2 5NDD
TM3 124 3.55x55 PAR2 5NDD PAR2 5NDD
TM3 125 3.56x56 PAR2 5NDD μ receptor 6DDE
ICL2 126 34.50x50 - - - -
ICL2 127 34.51x51 LPA6 receptor 5XSZ P2Y1 receptor 4XNW
ICL2 128 34.52x52 LPA6 receptor 5XSZ A2A receptor 4UHR
ICL2 129 34.53x53 LPA6 receptor 5XSZ - -
ICL2 130 34.54x54 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
ICL2 131 34.55x55 LPA6 receptor 5XSZ D3 receptor 3PBL
ICL2 132 34.56x56 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
ICL2 133 34.57x57 - - - -
TM4 134 4.38x38 PAR2 5NDD CCR9 5LWE
TM4 135 4.39x39 PAR2 5NDD μ receptor 6DDE
TM4 136 4.40x40 PAR2 5NDD μ receptor 6DDE
TM4 137 4.41x41 PAR2 5NDD AT1 receptor 4ZUD
TM4 138 4.42x42 PAR2 5NDD PAR2 5NDD
TM4 139 4.43x43 PAR2 5NDD BLT1 receptor 5X33
TM4 140 4.44x44 PAR2 5NDD δ receptor 4N6H
TM4 141 4.45x45 PAR2 5NDD P2Y12 receptor 4NTJ
TM4 142 4.46x46 PAR2 5NDD PAR1 3VW7
TM4 143 4.47x47 PAR2 5NDD PAR2 5NDD
TM4 144 4.48x48 PAR2 5NDD CXCR4 3ODU
TM4 145 4.49x49 PAR2 5NDD P2Y1 receptor 4XNW
TM4 146 4.50x50 PAR2 5NDD PAR2 5NDD
TM4 147 4.51x51 PAR2 5NDD PAR1 3VW7
TM4 148 4.52x52 PAR2 5NDD PAR2 5NDD
TM4 149 4.53x53 PAR2 5NDD PAR2 5NDD
TM4 150 4.54x54 PAR2 5NDD PAR2 5NDD
TM4 151 4.55x55 PAR2 5NDD P2Y1 receptor 4XNW
TM4 152 4.56x56 PAR2 5NDD - -
TM4 153 4.57x57 PAR2 5NDD PAF receptor 5ZKQ
TM4 154 4.58x59 PAR2 5NDD PAR1 3VW7
TM4 155 4.59x60 PAR2 5NDD PAR2 5NDD
TM4 156 4.60x61 PAR2 5NDD AT1 receptor 4ZUD
TM4 157 4.61x62 PAR2 5NDD C5a1 receptor 5O9H
TM4 158 4.62x63 PAR2 5NDD - -
ECL2 159 - - - -
ECL2 160 NTS1 receptor 4XES - -
ECL2 161 NTS1 receptor 4XES - -
ECL2 162 NTS1 receptor 4XES - -
ECL2 163 NTS1 receptor 4XES - -
ECL2 164 NTS1 receptor 4XES - -
ECL2 165 NTS1 receptor 4XES - -
ECL2 166 NTS1 receptor 4XES - -
ECL2 167 NTS1 receptor 4XES - -
ECL2 168 NTS1 receptor 4XES - -
ECL2 169 NTS1 receptor 4XES - -
ECL2 170 NTS1 receptor 4XES - -
ECL2 171 NTS1 receptor 4XES - -
ECL2 172 NTS1 receptor 4XES - -
ECL2 173 NTS1 receptor 4XES - -
ECL2 174 - - - -
ECL2 175 45.50x50 PAR2 5NDD PAR2 5NDD
ECL2 176 45.51x51 PAR2 5NDD PAF receptor 5ZKQ
ECL2 177 45.52x52 PAR2 5NDD PAF receptor 5ZKQ
ECL2 178 PAR2 5NDD - -
ECL2 179 PAR2 5NDD - -
ECL2 180 PAR2 5NDD - -
ECL2 181 PAR2 5NDD - -
ECL2 182 PAR2 5NDD - -
ECL2 183 PAR2 5NDD PAR2 5NDD
TM5 184 5.31x32 PAR2 5NDD - -
TM5 185 5.32x33 PAR2 5NDD C5a1 receptor 5O9H
TM5 186 5.33x34 PAR2 5NDD PAR2 5NDD
TM5 187 5.34x35 PAR2 5NDD C5a1 receptor 5O9H
TM5 188 5.35x36 PAR2 5NDD NTS1 receptor 4BUO
TM5 189 5.36x37 PAR2 5NDD PAF receptor 5ZKQ
TM5 190 5.37x38 PAR2 5NDD FFA1 receptor 5TZY
TM5 191 5.38x39 PAR2 5NDD μ receptor 6DDE
TM5 192 5.39x40 PAR2 5NDD LPA6 receptor 5XSZ
TM5 193 5.40x41 PAR2 5NDD PAR2 5NDD
TM5 194 5.41x42 PAR2 5NDD Y1 receptor 5ZBH
TM5 195 5.42x43 PAR2 5NDD - -
TM5 196 5.43x44 PAR2 5NDD LPA6 receptor 5XSZ
TM5 197 5.44x45 PAR2 5NDD - -
TM5 198 5.45x46 PAR2 5NDD FFA1 receptor 5TZY
TM5 199 5.46x461 PAR2 5NDD LPA6 receptor 5XSZ
TM5 200 5.47x47 PAR2 5NDD PAR2 5NDD
TM5 201 5.48x48 PAR2 5NDD PAR2 5NDD
TM5 202 5.49x49 PAR2 5NDD PAF receptor 5ZKQ
TM5 203 5.50x50 PAR2 5NDD PAR2 5NDD
TM5 204 5.51x51 PAR2 5NDD PAR1 3VW7
TM5 205 5.52x52 PAR2 5NDD 5-HT2B receptor 4IB4
TM5 206 5.53x53 PAR2 5NDD - -
TM5 207 5.54x54 PAR2 5NDD P2Y12 receptor 4NTJ
TM5 208 5.55x55 PAR2 5NDD LPA6 receptor 5XSZ
TM5 209 5.56x56 PAR2 5NDD US28 4XT1
TM5 210 5.57x57 PAR2 5NDD AT1 receptor 4ZUD
TM5 211 5.58x58 PAR2 5NDD LPA6 receptor 5XSZ
TM5 212 5.59x59 PAR2 5NDD μ receptor 6DDE
TM5 213 5.60x60 PAR2 5NDD 5-HT1B receptor 5V54
TM5 214 5.61x61 PAR2 5NDD LPA6 receptor 5XSZ
TM5 215 5.62x62 PAR2 5NDD A2A receptor 4UHR
TM5 216 5.63x63 PAR2 5NDD CB1 receptor 5XRA
TM5 217 5.64x64 PAR2 5NDD PAF receptor 5ZKQ
TM5 218 5.65x65 PAR2 5NDD PAR2 5NDD
TM5 219 5.66x66 - - - -
TM5 220 5.67x67 - - - -
ICL3 221 - - - -
ICL3 222 - - - -
ICL3 223 - - - -
ICL3 224 - - - -
TM6 225 6.26x26 κ receptor 6B73 OX2 receptor 5WS3
TM6 226 6.27x27 PAR2 5NDD PAR2 5NDD
TM6 227 6.28x28 PAR2 5NDD NTS1 receptor 4XEE
TM6 228 6.29x29 PAR2 5NDD 5-HT1B receptor 5V54
TM6 229 6.30x30 PAR2 5NDD FFA1 receptor 5TZY
TM6 230 6.31x31 PAR2 5NDD PAR2 5NDD
TM6 231 6.32x32 PAR2 5NDD PAR2 5NDD
TM6 232 6.33x33 PAR2 5NDD C5a1 receptor 5O9H
TM6 233 6.34x34 PAR2 5NDD NTS1 receptor 4XES
TM6 234 6.35x35 PAR2 5NDD μ receptor 6DDE
TM6 235 6.36x36 PAR2 5NDD CCR5 5UIW
TM6 236 6.37x37 PAR2 5NDD PAR2 5NDD
TM6 237 6.38x38 PAR2 5NDD μ receptor 6DDE
TM6 238 6.39x39 PAR2 5NDD PAR1 3VW7
TM6 239 6.40x40 PAR2 5NDD - -
TM6 240 6.41x41 PAR2 5NDD 5-HT1B receptor 4IAQ
TM6 241 6.42x42 PAR2 5NDD apelin receptor 5VBL
TM6 242 6.43x43 PAR2 5NDD LPA6 receptor 5XSZ
TM6 243 6.44x44 PAR2 5NDD μ receptor 6DDE
TM6 244 6.45x45 PAR2 5NDD 5-HT2B receptor 4IB4
TM6 245 6.46x46 LPA6 receptor 5XSZ PAR2 5NDD
TM6 246 6.47x47 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM6 247 6.48x48 PAR2 5NDD PAR2 5NDD
TM6 248 6.49x49 PAR2 5NDD P2Y12 receptor 4NTJ
TM6 249 6.50x50 PAR2 5NDD PAR2 5NDD
TM6 250 6.51x51 PAR2 5NDD NTS1 receptor 4XES
TM6 251 6.52x52 PAR2 5NDD PAR2 5NDD
TM6 252 6.53x53 PAR2 5NDD Rhodopsin 4ZWJ
TM6 253 6.54x54 PAR2 5NDD 5-HT2B receptor 4IB4
TM6 254 6.55x55 PAR2 5NDD PAR2 5NDD
TM6 255 6.56x56 PAR2 5NDD - -
TM6 256 6.57x57 PAR2 5NDD PAR2 5NDD
TM6 257 6.58x58 PAR2 5NDD P2Y12 receptor 4NTJ
TM6 258 6.59x59 PAR2 5NDD BLT1 receptor 5X33
TM6 259 6.60x60 PAR2 5NDD P2Y12 receptor 4NTJ
TM6 260 6.61x61 PAR2 5NDD PAR2 5NDD
TM6 261 6.62x62 PAR2 5NDD P2Y1 receptor 4XNW
TM6 262 6.63x63 LPA6 receptor 5XSZ - -
TM6 263 6.64x64 LPA6 receptor 5XSZ US28 4XT1
ECL3 264 - - - -
ECL3 265 CXCR4 3ODU - -
ECL3 266 CXCR4 3ODU - -
ECL3 267 - - - -
TM7 268 7.24x23 LPA6 receptor 5XSZ AT2 receptor 5UNG
TM7 269 7.25x24 LPA6 receptor 5XSZ - -
TM7 270 7.26x25 LPA6 receptor 5XSZ C5a1 receptor 5O9H
TM7 271 7.27x26 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM7 272 7.28x27 LPA6 receptor 5XSZ OX2 receptor 5WS3
TM7 273 7.29x28 LPA6 receptor 5XSZ P2Y1 receptor 4XNW
TM7 274 7.30x29 LPA6 receptor 5XSZ P2Y1 receptor 4XNW
TM7 275 7.31x30 PAR2 5NDD PAR2 5NDD
TM7 276 7.32x31 PAR2 5NDD LPA6 receptor 5XSZ
TM7 277 7.33x32 PAR2 5NDD - -
TM7 278 7.34x33 PAR2 5NDD P2Y12 receptor 4NTJ
TM7 279 7.35x34 PAR2 5NDD 5-HT2B receptor 4IB4
TM7 280 7.36x35 PAR2 5NDD NTS1 receptor 4XES
TM7 281 7.37x36 PAR2 5NDD PAR2 5NDD
TM7 282 7.38x37 PAR2 5NDD - -
TM7 283 7.39x38 PAR2 5NDD PAR1 3VW7
TM7 284 7.40x39 PAR2 5NDD AT2 receptor 5UNG
TM7 285 7.41x40 PAR2 5NDD PAR2 5NDD
TM7 286 7.42x41 PAR2 5NDD P2Y1 receptor 4XNW
TM7 287 7.43x42 PAR2 5NDD - -
TM7 288 7.44x43 PAR2 5NDD NTS1 receptor 4XES
TM7 289 7.45x45 PAR2 5NDD PAR2 5NDD
TM7 290 7.46x46 PAR2 5NDD PAR1 3VW7
TM7 291 7.47x47 PAR2 5NDD PAF receptor 5ZKQ
TM7 292 7.48x48 PAR2 5NDD μ receptor 6DDE
TM7 293 7.49x49 PAR2 5NDD PAR2 5NDD
TM7 294 7.50x50 PAR2 5NDD PAR2 5NDD
TM7 295 7.51x51 PAR2 5NDD PAR1 3VW7
TM7 296 7.52x52 PAR2 5NDD PAR2 5NDD
TM7 297 7.53x53 PAR2 5NDD PAR2 5NDD
TM7 298 7.54x54 PAR2 5NDD PAR2 5NDD
TM7 299 7.55x55 PAR2 5NDD PAR2 5NDD
TM7 300 7.56x56 PAR2 5NDD 5-HT1B receptor 4IAQ
H8 301 8.47x47 PAR2 5NDD - -
H8 302 8.48x48 PAR2 5NDD 5-HT1B receptor 4IAQ
H8 303 8.49x49 PAR2 5NDD - -
H8 304 8.50x50 PAR2 5NDD PAR2 5NDD
H8 305 8.51x51 PAR2 5NDD PAR2 5NDD
H8 306 8.52x52 PAR2 5NDD P2Y12 receptor 4NTJ
H8 307 8.53x53 PAR2 5NDD A2A receptor 4UHR
H8 308 8.54x54 PAR2 5NDD CCR5 5UIW
H8 309 8.55x55 PAR2 5NDD A2A receptor 4UHR
H8 310 8.56x56 PAR2 5NDD - -
H8 311 8.57x57 PAR2 5NDD 5-HT1B receptor 4IAQ
H8 312 8.58x58 PAR2 5NDD - -
H8 313 8.59x59 US28 4XT1 5-HT2B receptor 5TUD
H8 314 8.60x60 US28 4XT1 - -
H8 315 8.61x61 US28 4XT1 A2A receptor 4UHR
C-term 316 - - - -
C-term 317 - - - -
C-term 318 - - - -
C-term 319 - - - -
C-term 320 - - - -