LH receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive (Δ distance (Å): 0.29 docs)

VERSION

2018-07-10

MAIN TEMPLATE

H1 receptor (sequence similarity: 40%) PDB: 3RZE

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 76.5 14.9 8.7
Side-chains 17.6 55.7 26.6

Number of backbone templates: 8
Number of rotamer templates: 41

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5DYS
3RZE
4ZUD
5WS3
4UHR
4N6H
5NDD
3V2Y
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 356 Rhodopsin 5DYS Rhodopsin 5DYS
N-term 357 Rhodopsin 5DYS Rhodopsin 5DYS
N-term 358 Rhodopsin 5DYS Rhodopsin 5DYS
N-term 359 Rhodopsin 5DYS Rhodopsin 5DYS
N-term 360 Rhodopsin 5DYS Rhodopsin 5DYS
TM1 361 1.34x34 Rhodopsin 5DYS M1 receptor 5CXV
TM1 362 1.35x35 Rhodopsin 5DYS Rhodopsin 5DYS
TM1 363 1.36x36 Rhodopsin 5DYS - -
TM1 364 1.37x37 Rhodopsin 5DYS D4 receptor 5WIV
TM1 365 1.38x38 H1 receptor 3RZE AT1 receptor 4ZUD
TM1 366 1.39x39 H1 receptor 3RZE 5-HT2C receptor 6BQH
TM1 367 1.40x40 H1 receptor 3RZE CCR9 5LWE
TM1 368 1.41x41 H1 receptor 3RZE Rhodopsin 1GZM
TM1 369 1.42x42 H1 receptor 3RZE H1 receptor 3RZE
TM1 370 1.43x43 H1 receptor 3RZE - -
TM1 371 1.44x44 H1 receptor 3RZE CCR2 5T1A
TM1 372 1.45x45 H1 receptor 3RZE Rhodopsin 1GZM
TM1 373 1.46x46 H1 receptor 3RZE A2A receptor 3VG9
TM1 374 1.47x47 H1 receptor 3RZE A2A receptor 3VG9
TM1 375 1.48x48 H1 receptor 3RZE - -
TM1 376 1.49x49 H1 receptor 3RZE A2A receptor 3VG9
TM1 377 1.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM1 378 1.51x51 H1 receptor 3RZE CCR2 5T1A
TM1 379 1.52x52 H1 receptor 3RZE ETB receptor 5X93
TM1 380 1.53x53 H1 receptor 3RZE H1 receptor 3RZE
TM1 381 1.54x54 H1 receptor 3RZE H1 receptor 3RZE
TM1 382 1.55x55 H1 receptor 3RZE κ receptor 4DJH
TM1 383 1.56x56 H1 receptor 3RZE Rhodopsin 1GZM
TM1 384 1.57x57 H1 receptor 3RZE CCR2 5T1A
TM1 385 1.58x58 H1 receptor 3RZE CB1 receptor 5TGZ
TM1 386 1.59x59 H1 receptor 3RZE D4 receptor 5WIV
TM1 387 1.60x60 H1 receptor 3RZE CB1 receptor 5TGZ
ICL1 388 - - - -
ICL1 389 12.48x48 H1 receptor 3RZE - -
ICL1 390 12.49x49 H1 receptor 3RZE H1 receptor 3RZE
ICL1 391 12.50x50 H1 receptor 3RZE H1 receptor 3RZE
ICL1 392 12.51x51 H1 receptor 3RZE - -
TM2 393 2.38x38 H1 receptor 3RZE H1 receptor 3RZE
TM2 394 2.39x39 H1 receptor 3RZE ETB receptor 5X93
TM2 395 2.40x40 H1 receptor 3RZE - -
TM2 396 2.41x41 H1 receptor 3RZE - -
TM2 397 2.42x42 H1 receptor 3RZE D2 receptor 6CM4
TM2 398 2.43x43 H1 receptor 3RZE LPA1 receptor 4Z35
TM2 399 2.44x44 H1 receptor 3RZE - -
TM2 400 2.45x45 H1 receptor 3RZE Rhodopsin 1GZM
TM2 401 2.46x46 H1 receptor 3RZE H1 receptor 3RZE
TM2 402 2.47x47 H1 receptor 3RZE H1 receptor 3RZE
TM2 403 2.48x48 H1 receptor 3RZE Y1 receptor 5ZBH
TM2 404 2.49x49 H1 receptor 3RZE H1 receptor 3RZE
TM2 405 2.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM2 406 2.51x51 H1 receptor 3RZE LPA1 receptor 4Z35
TM2 407 2.52x52 H1 receptor 3RZE AT1 receptor 4ZUD
TM2 408 2.53x53 H1 receptor 3RZE Rhodopsin 1GZM
TM2 409 2.54x54 H1 receptor 3RZE H1 receptor 3RZE
TM2 410 2.55x55 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM2 411 2.56x56 AT1 receptor 4ZUD - -
TM2 412 2.57x57 H1 receptor 3RZE AT1 receptor 4ZUD
TM2 413 2.58x58 H1 receptor 3RZE - -
TM2 414 2.59x59 H1 receptor 3RZE AT1 receptor 4ZUD
TM2 415 2.60x60 H1 receptor 3RZE Rhodopsin 5DYS
TM2 416 2.61x61 H1 receptor 3RZE AT1 receptor 4ZUD
TM2 417 2.62x62 H1 receptor 3RZE PAR1 3VW7
TM2 418 2.63x63 H1 receptor 3RZE κ receptor 4DJH
TM2 419 2.64x64 H1 receptor 3RZE OX2 receptor 5WS3
TM2 420 2.65x65 H1 receptor 3RZE AT2 receptor 5UNG
TM2 421 2.66x66 H1 receptor 3RZE D4 receptor 5WIV
TM2 422 2.67x67 OX2 receptor 5WS3 - -
ECL1 423 H1 receptor 3RZE - -
ECL1 424 - - - -
ECL1 425 - - - -
ECL1 426 - - - -
ECL1 427 - - - -
ECL1 428 - - - -
ECL1 429 - - - -
ECL1 430 - - - -
ECL1 431 - - - -
ECL1 432 23.49x49 H1 receptor 3RZE apelin receptor 5VBL
ECL1 433 23.50x50 H1 receptor 3RZE H1 receptor 3RZE
ECL1 434 23.51x51 H1 receptor 3RZE A1 receptor 5N2S
ECL1 435 23.52x52 H1 receptor 3RZE - -
TM3 436 3.22x22 H1 receptor 3RZE C5a1 receptor 5O9H
TM3 437 3.23x23 H1 receptor 3RZE OX2 receptor 5WS3
TM3 438 3.24x24 H1 receptor 3RZE Rhodopsin 1GZM
TM3 439 3.25x25 H1 receptor 3RZE H1 receptor 3RZE
TM3 440 3.26x26 H1 receptor 3RZE C5a1 receptor 5O9H
TM3 441 3.27x27 H1 receptor 3RZE NOP receptor 5DHG
TM3 442 3.28x28 H1 receptor 3RZE AT1 receptor 4ZUD
TM3 443 3.29x29 H1 receptor 3RZE Rhodopsin 1GZM
TM3 444 3.30x30 H1 receptor 3RZE Rhodopsin 1GZM
TM3 445 3.31x31 H1 receptor 3RZE Rhodopsin 1GZM
TM3 446 3.32x32 H1 receptor 3RZE - -
TM3 447 3.33x33 H1 receptor 3RZE β2-adrenoceptor 5JQH
TM3 448 3.34x34 H1 receptor 3RZE AT1 receptor 4ZUD
TM3 449 3.35x35 H1 receptor 3RZE H1 receptor 3RZE
TM3 450 3.36x36 H1 receptor 3RZE H1 receptor 3RZE
TM3 451 3.37x37 H1 receptor 3RZE Rhodopsin 1GZM
TM3 452 3.38x38 H1 receptor 3RZE - -
TM3 453 3.39x39 H1 receptor 3RZE H1 receptor 3RZE
TM3 454 3.40x40 H1 receptor 3RZE AT1 receptor 4ZUD
TM3 455 3.41x41 H1 receptor 3RZE - -
TM3 456 3.42x42 H1 receptor 3RZE κ receptor 4DJH
TM3 457 3.43x43 H1 receptor 3RZE Rhodopsin 1GZM
TM3 458 3.44x44 H1 receptor 3RZE AT1 receptor 4ZUD
TM3 459 3.45x45 H1 receptor 3RZE Rhodopsin 1GZM
TM3 460 3.46x46 H1 receptor 3RZE A2A receptor 3VG9
TM3 461 3.47x47 H1 receptor 3RZE CCR2 5T1A
TM3 462 3.48x48 H1 receptor 3RZE OX2 receptor 5WS3
TM3 463 3.49x49 H1 receptor 3RZE Rhodopsin 1GZM
TM3 464 3.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM3 465 3.51x51 H1 receptor 3RZE OX2 receptor 5WS3
TM3 466 3.52x52 H1 receptor 3RZE - -
TM3 467 3.53x53 H1 receptor 3RZE S1P1 receptor 3V2Y
TM3 468 3.54x54 H1 receptor 3RZE A2A receptor 3VG9
TM3 469 3.55x55 H1 receptor 3RZE β2-adrenoceptor 5JQH
TM3 470 3.56x56 H1 receptor 3RZE AT2 receptor 5UNG
ICL2 471 34.50x50 - - - -
ICL2 472 34.51x51 A2A receptor 4UHR C5a1 receptor 6C1R
ICL2 473 34.52x52 A2A receptor 4UHR D3 receptor 3PBL
ICL2 474 34.53x53 A2A receptor 4UHR - -
ICL2 475 34.54x54 A2A receptor 4UHR - -
ICL2 476 34.55x55 A2A receptor 4UHR - -
ICL2 477 34.56x56 A2A receptor 4UHR M1 receptor 5CXV
ICL2 478 34.57x57 - - - -
TM4 479 4.38x38 H1 receptor 3RZE FFA1 receptor 5TZY
TM4 480 4.39x39 H1 receptor 3RZE CXCR4 3ODU
TM4 481 4.40x40 H1 receptor 3RZE A1 receptor 5UEN
TM4 482 4.41x41 H1 receptor 3RZE Rhodopsin 1GZM
TM4 483 4.42x42 H1 receptor 3RZE H1 receptor 3RZE
TM4 484 4.43x43 H1 receptor 3RZE Rhodopsin 1GZM
TM4 485 4.44x44 H1 receptor 3RZE δ receptor 4N6H
TM4 486 4.45x45 H1 receptor 3RZE A2A receptor 3VG9
TM4 487 4.46x46 H1 receptor 3RZE - -
TM4 488 4.47x47 H1 receptor 3RZE H1 receptor 3RZE
TM4 489 4.48x48 H1 receptor 3RZE H1 receptor 3RZE
TM4 490 4.49x49 H1 receptor 3RZE - -
TM4 491 4.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM4 492 4.51x51 H1 receptor 3RZE AT1 receptor 4ZUD
TM4 493 4.52x52 H1 receptor 3RZE 5-HT1B receptor 4IAQ
TM4 494 4.53x53 H1 receptor 3RZE H1 receptor 3RZE
TM4 495 4.54x54 H1 receptor 3RZE κ receptor 4DJH
TM4 496 4.55x55 Rhodopsin 5DYS Rhodopsin 5DYS
TM4 497 4.56x56 Rhodopsin 5DYS A2A receptor 3VG9
TM4 498 4.57x57 Rhodopsin 5DYS Rhodopsin 5DYS
TM4 499 4.58x58 H1 receptor 3RZE - -
TM4 500 4.59x59 H1 receptor 3RZE AT1 receptor 4ZUD
TM4 501 4.60x60 H1 receptor 3RZE H1 receptor 3RZE
TM4 502 4.61x61 H1 receptor 3RZE Rhodopsin 1GZM
TM4 503 4.62x62 H1 receptor 3RZE Rhodopsin 1GZM
ECL2 504 - - - -
ECL2 505 δ receptor 4N6H - -
ECL2 506 δ receptor 4N6H - -
ECL2 507 δ receptor 4N6H - -
ECL2 508 δ receptor 4N6H - -
ECL2 509 δ receptor 4N6H - -
ECL2 510 δ receptor 4N6H - -
ECL2 511 δ receptor 4N6H - -
ECL2 512 δ receptor 4N6H - -
ECL2 513 - - - -
ECL2 514 45.50x50 H1 receptor 3RZE H1 receptor 3RZE
ECL2 515 45.51x51 H1 receptor 3RZE M4 receptor 5DSG
ECL2 516 45.52x52 H1 receptor 3RZE - -
ECL2 517 - - - -
ECL2 518 PAR2 5NDD - -
ECL2 519 PAR2 5NDD - -
ECL2 520 PAR2 5NDD PAR2 5NDD
ECL2 521 PAR2 5NDD - -
ECL2 522 - - - -
TM5 523 5.35x35 Rhodopsin 5DYS AT1 receptor 4ZUD
TM5 524 5.36x36 H1 receptor 3RZE A1 receptor 5UEN
TM5 525 5.37x37 H1 receptor 3RZE β2-adrenoceptor 5JQH
TM5 526 5.38x38 H1 receptor 3RZE δ receptor 4N6H
TM5 527 5.39x39 H1 receptor 3RZE A2A receptor 3VG9
TM5 528 5.40x40 H1 receptor 3RZE S1P1 receptor 3V2Y
TM5 529 5.41x41 H1 receptor 3RZE AT1 receptor 4ZUD
TM5 530 5.42x42 H1 receptor 3RZE AT1 receptor 4ZUD
TM5 531 5.43x43 H1 receptor 3RZE NOP receptor 5DHG
TM5 532 5.44x44 H1 receptor 3RZE Y1 receptor 5ZBH
TM5 533 5.45x45 H1 receptor 3RZE H1 receptor 3RZE
TM5 534 5.46x46 S1P1 receptor 3V2Y AT1 receptor 4YAY
TM5 535 5.47x47 S1P1 receptor 3V2Y LPA1 receptor 4Z35
TM5 536 5.48x48 H1 receptor 3RZE κ receptor 4DJH
TM5 537 5.49x49 H1 receptor 3RZE A2A receptor 3VG9
TM5 538 5.50x50 H1 receptor 3RZE - -
TM5 539 5.51x51 H1 receptor 3RZE AT1 receptor 4ZUD
TM5 540 5.52x52 H1 receptor 3RZE PAR2 5NDD
TM5 541 5.53x53 H1 receptor 3RZE AT1 receptor 4ZUD
TM5 542 5.54x54 H1 receptor 3RZE Rhodopsin 1GZM
TM5 543 5.55x55 H1 receptor 3RZE M1 receptor 5CXV
TM5 544 5.56x56 H1 receptor 3RZE BLT1 receptor 5X33
TM5 545 5.57x57 H1 receptor 3RZE Rhodopsin 1GZM
TM5 546 5.58x58 H1 receptor 3RZE H1 receptor 3RZE
TM5 547 5.59x59 H1 receptor 3RZE D2 receptor 6CM4
TM5 548 5.60x60 H1 receptor 3RZE H1 receptor 3RZE
TM5 549 5.61x61 H1 receptor 3RZE H1 receptor 3RZE
TM5 550 5.62x62 H1 receptor 3RZE H1 receptor 3RZE
TM5 551 5.63x63 H1 receptor 3RZE Rhodopsin 1GZM
TM5 552 5.64x64 H1 receptor 3RZE H1 receptor 3RZE
TM5 553 5.65x65 H1 receptor 3RZE H1 receptor 3RZE
TM5 554 5.66x66 Rhodopsin 5DYS A2A receptor 3VG9
TM5 555 5.67x67 Rhodopsin 5DYS - -
ICL3 556 - - - -
ICL3 557 - - - -
ICL3 558 - - - -
ICL3 559 - - - -
TM6 560 6.26x26 Rhodopsin 5DYS 5-HT2C receptor 6BQH
TM6 561 6.27x27 Rhodopsin 5DYS FFA1 receptor 5TZY
TM6 562 6.28x28 H1 receptor 3RZE H1 receptor 3RZE
TM6 563 6.29x29 H1 receptor 3RZE A2A receptor 3VG9
TM6 564 6.30x30 H1 receptor 3RZE CB1 receptor 5TGZ
TM6 565 6.31x31 H1 receptor 3RZE C5a1 receptor 6C1R
TM6 566 6.32x32 H1 receptor 3RZE H1 receptor 3RZE
TM6 567 6.33x33 H1 receptor 3RZE AT1 receptor 4ZUD
TM6 568 6.34x34 H1 receptor 3RZE H1 receptor 3RZE
TM6 569 6.35x35 H1 receptor 3RZE H1 receptor 3RZE
TM6 570 6.36x36 H1 receptor 3RZE PAR2 5NDD
TM6 571 6.37x37 H1 receptor 3RZE PAF receptor 5ZKP
TM6 572 6.38x38 H1 receptor 3RZE A2A receptor 3VG9
TM6 573 6.39x39 H1 receptor 3RZE Rhodopsin 1GZM
TM6 574 6.40x40 H1 receptor 3RZE apelin receptor 5VBL
TM6 575 6.41x41 H1 receptor 3RZE BLT1 receptor 5X33
TM6 576 6.42x42 H1 receptor 3RZE A1 receptor 5UEN
TM6 577 6.43x43 H1 receptor 3RZE β2-adrenoceptor 5JQH
TM6 578 6.44x44 H1 receptor 3RZE - -
TM6 579 6.45x45 H1 receptor 3RZE AT1 receptor 4ZUD
TM6 580 6.46x46 H1 receptor 3RZE - -
TM6 581 6.47x47 H1 receptor 3RZE H1 receptor 3RZE
TM6 582 6.48x48 H1 receptor 3RZE - -
TM6 583 6.49x49 H1 receptor 3RZE δ receptor 4N6H
TM6 584 6.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM6 585 6.51x51 H1 receptor 3RZE κ receptor 4DJH
TM6 586 6.52x52 H1 receptor 3RZE OX2 receptor 5WS3
TM6 587 6.53x53 H1 receptor 3RZE P2Y12 receptor 4NTJ
TM6 588 6.54x54 H1 receptor 3RZE H1 receptor 3RZE
TM6 589 6.55x55 H1 receptor 3RZE Rhodopsin 1GZM
TM6 590 6.56x56 H1 receptor 3RZE β2-adrenoceptor 5JQH
TM6 591 6.57x57 H1 receptor 3RZE - -
TM6 592 6.58x58 H1 receptor 3RZE - -
TM6 593 6.59x59 H1 receptor 3RZE H1 receptor 3RZE
TM6 594 6.60x60 H1 receptor 3RZE H1 receptor 3RZE
TM6 595 6.61x61 H1 receptor 3RZE US28 4XT1
ECL3 596 - - - -
ECL3 597 Rhodopsin 5DYS - -
ECL3 598 Rhodopsin 5DYS - -
ECL3 599 Rhodopsin 5DYS - -
ECL3 600 - - - -
TM7 601 7.31x30 H1 receptor 3RZE - -
TM7 602 7.32x31 H1 receptor 3RZE μ receptor 4DKL
TM7 603 7.33x32 H1 receptor 3RZE apelin receptor 5VBL
TM7 604 7.34x33 H1 receptor 3RZE κ receptor 4DJH
TM7 605 7.35x34 H1 receptor 3RZE P2Y12 receptor 4NTJ
TM7 606 7.36x35 H1 receptor 3RZE - -
TM7 607 7.37x36 H1 receptor 3RZE A2A receptor 3VG9
TM7 608 7.38x37 H1 receptor 3RZE β2-adrenoceptor 5JQH
TM7 609 7.39x38 H1 receptor 3RZE 5-HT2C receptor 6BQH
TM7 610 7.40x39 H1 receptor 3RZE Y1 receptor 5ZBH
TM7 611 7.41x40 H1 receptor 3RZE Rhodopsin 1GZM
TM7 612 7.42x41 H1 receptor 3RZE - -
TM7 613 7.43x42 H1 receptor 3RZE - -
TM7 614 7.44x43 H1 receptor 3RZE H1 receptor 3RZE
TM7 615 7.45x45 H1 receptor 3RZE H1 receptor 3RZE
TM7 616 7.46x46 H1 receptor 3RZE H1 receptor 3RZE
TM7 617 7.47x47 H1 receptor 3RZE AT1 receptor 4ZUD
TM7 618 7.48x48 H1 receptor 3RZE OX2 receptor 5WS3
TM7 619 7.49x49 H1 receptor 3RZE H1 receptor 3RZE
TM7 620 7.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM7 621 7.51x51 H1 receptor 3RZE A2A receptor 3VG9
TM7 622 7.52x52 H1 receptor 3RZE κ receptor 4DJH
TM7 623 7.53x53 H1 receptor 3RZE H1 receptor 3RZE
TM7 624 7.54x54 H1 receptor 3RZE A2A receptor 3VG9
TM7 625 7.55x55 H1 receptor 3RZE - -
TM7 626 7.56x56 H1 receptor 3RZE D2 receptor 6CM4
H8 627 8.47x47 H1 receptor 3RZE - -
H8 628 8.48x48 H1 receptor 3RZE Rhodopsin 1GZM
H8 629 8.49x49 H1 receptor 3RZE M2 receptor 3UON
H8 630 8.50x50 H1 receptor 3RZE H1 receptor 3RZE
H8 631 8.51x51 H1 receptor 3RZE Y1 receptor 5ZBH
H8 632 8.52x52 H1 receptor 3RZE κ receptor 4DJH
H8 633 8.53x53 H1 receptor 3RZE Y1 receptor 5ZBH
H8 634 8.54x54 H1 receptor 3RZE H1 receptor 3RZE
H8 635 8.55x55 H1 receptor 3RZE - -
H8 636 8.56x56 H1 receptor 3RZE M1 receptor 5CXV
H8 637 8.57x57 H1 receptor 3RZE β2-adrenoceptor 5JQH
H8 638 8.58x58 H1 receptor 3RZE H1 receptor 3RZE
H8 639 8.59x59 H1 receptor 3RZE OX2 receptor 5WS3
C-term 640 H1 receptor 3RZE H1 receptor 3RZE
C-term 641 - - - -
C-term 642 - - - -
C-term 643 - - - -
C-term 644 - - - -