LH receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate (Δ distance (Å): 6.22 docs)

VERSION

2018-07-10

MAIN TEMPLATE

A2A receptor (sequence similarity: 37%) PDB: 4UHR

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 80.7 10.0 9.3
Side-chains 19.3 54.1 26.6

Number of backbone templates: 9
Number of rotamer templates: 40

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4UHR
3RZE
4ZUD
5WS3
6FK6
5DYS
4N6H
5NDD
3V2Y
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 356 - - - -
N-term 357 - - - -
N-term 358 - - - -
N-term 359 - - - -
N-term 360 - - - -
TM1 361 1.34x34 A2A receptor 4UHR PAR2 5NDD
TM1 362 1.35x35 A2A receptor 4UHR PAR2 5NDD
TM1 363 1.36x36 A2A receptor 4UHR - -
TM1 364 1.37x37 A2A receptor 4UHR D4 receptor 5WIV
TM1 365 1.38x38 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM1 366 1.39x39 A2A receptor 4UHR 5-HT2C receptor 6BQH
TM1 367 1.40x40 A2A receptor 4UHR CCR9 5LWE
TM1 368 1.41x41 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM1 369 1.42x42 A2A receptor 4UHR A2A receptor 4UHR
TM1 370 1.43x43 A2A receptor 4UHR - -
TM1 371 1.44x44 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM1 372 1.45x45 A2A receptor 4UHR A2A receptor 4UHR
TM1 373 1.46x46 A2A receptor 4UHR A2A receptor 4UHR
TM1 374 1.47x47 A2A receptor 4UHR A2A receptor 4UHR
TM1 375 1.48x48 A2A receptor 4UHR - -
TM1 376 1.49x49 A2A receptor 4UHR A2A receptor 4UHR
TM1 377 1.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM1 378 1.51x51 A2A receptor 4UHR CCR2 5T1A
TM1 379 1.52x52 A2A receptor 4UHR ETB receptor 5X93
TM1 380 1.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM1 381 1.54x54 A2A receptor 4UHR PAR2 5NDD
TM1 382 1.55x55 A2A receptor 4UHR NTS1 receptor 4XES
TM1 383 1.56x56 A2A receptor 4UHR PAR2 5NDD
TM1 384 1.57x57 A2A receptor 4UHR NTS1 receptor 4XES
TM1 385 1.58x58 A2A receptor 4UHR PAR2 5NDD
TM1 386 1.59x59 A2A receptor 4UHR D4 receptor 5WIV
TM1 387 1.60x60 A2A receptor 4UHR CB1 receptor 5TGZ
ICL1 388 - - - -
ICL1 389 12.48x48 H1 receptor 3RZE - -
ICL1 390 12.49x49 H1 receptor 3RZE H1 receptor 3RZE
ICL1 391 12.50x50 H1 receptor 3RZE H1 receptor 3RZE
ICL1 392 12.51x51 - - - -
TM2 393 2.38x38 A2A receptor 4UHR A2A receptor 4UHR
TM2 394 2.39x39 A2A receptor 4UHR ETB receptor 5X93
TM2 395 2.40x40 A2A receptor 4UHR - -
TM2 396 2.41x41 A2A receptor 4UHR - -
TM2 397 2.42x42 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM2 398 2.43x43 A2A receptor 4UHR PAR2 5NDD
TM2 399 2.44x44 A2A receptor 4UHR - -
TM2 400 2.45x45 A2A receptor 4UHR PAR2 5NDD
TM2 401 2.46x46 A2A receptor 4UHR PAR2 5NDD
TM2 402 2.47x47 A2A receptor 4UHR H1 receptor 3RZE
TM2 403 2.48x48 A2A receptor 4UHR Y1 receptor 5ZBH
TM2 404 2.49x49 A2A receptor 4UHR A2A receptor 4UHR
TM2 405 2.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM2 406 2.51x51 A2A receptor 4UHR P2Y1 receptor 4XNW
TM2 407 2.52x52 A2A receptor 4UHR AT1 receptor 4ZUD
TM2 408 2.53x53 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM2 409 2.54x54 A2A receptor 4UHR A2A receptor 4UHR
TM2 410 2.55x55 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM2 411 2.56x56 AT1 receptor 4ZUD - -
TM2 412 2.57x57 A2A receptor 4UHR μ receptor 6DDE
TM2 413 2.58x58 A2A receptor 4UHR - -
TM2 414 2.59x59 A2A receptor 4UHR PAR2 5NDD
TM2 415 2.60x60 A2A receptor 4UHR Rhodopsin 5DYS
TM2 416 2.61x61 A2A receptor 4UHR FFA1 receptor 5TZY
TM2 417 2.62x62 A2A receptor 4UHR PAR1 3VW7
TM2 418 2.63x63 A2A receptor 4UHR κ receptor 4DJH
TM2 419 2.64x64 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM2 420 2.65x65 A2A receptor 4UHR AT2 receptor 5UNG
TM2 421 2.66x66 A2A receptor 4UHR D4 receptor 5WIV
TM2 422 2.67x67 OX2 receptor 5WS3 - -
ECL1 423 - - - -
ECL1 424 - - - -
ECL1 425 - - - -
ECL1 426 - - - -
ECL1 427 - - - -
ECL1 428 - - - -
ECL1 429 - - - -
ECL1 430 - - - -
ECL1 431 - - - -
ECL1 432 23.49x49 Rhodopsin 6FK6 PAR1 3VW7
ECL1 433 23.50x50 Rhodopsin 6FK6 PAR2 5NDD
ECL1 434 23.51x51 Rhodopsin 6FK6 PAR1 3VW7
ECL1 435 23.52x52 - - - -
TM3 436 3.22x22 A2A receptor 4UHR C5a1 receptor 5O9H
TM3 437 3.23x23 A2A receptor 4UHR FFA1 receptor 5TZY
TM3 438 3.24x24 A2A receptor 4UHR A2A receptor 4UHR
TM3 439 3.25x25 A2A receptor 4UHR A2A receptor 4UHR
TM3 440 3.26x26 A2A receptor 4UHR C5a1 receptor 5O9H
TM3 441 3.27x27 A2A receptor 4UHR NOP receptor 5DHG
TM3 442 3.28x28 A2A receptor 4UHR PAF receptor 5ZKQ
TM3 443 3.29x29 A2A receptor 4UHR PAF receptor 5ZKQ
TM3 444 3.30x30 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM3 445 3.31x31 A2A receptor 4UHR A2A receptor 4UHR
TM3 446 3.32x32 A2A receptor 4UHR - -
TM3 447 3.33x33 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM3 448 3.34x34 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM3 449 3.35x35 A2A receptor 4UHR H1 receptor 3RZE
TM3 450 3.36x36 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM3 451 3.37x37 A2A receptor 4UHR Rhodopsin 5DYS
TM3 452 3.38x38 A2A receptor 4UHR - -
TM3 453 3.39x39 A2A receptor 4UHR A2A receptor 4UHR
TM3 454 3.40x40 A2A receptor 4UHR PAF receptor 5ZKQ
TM3 455 3.41x41 A2A receptor 4UHR - -
TM3 456 3.42x42 A2A receptor 4UHR μ receptor 6DDE
TM3 457 3.43x43 A2A receptor 4UHR A2A receptor 4UHR
TM3 458 3.44x44 A2A receptor 4UHR PAR2 5NDD
TM3 459 3.45x45 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM3 460 3.46x46 A2A receptor 4UHR A2A receptor 4UHR
TM3 461 3.47x47 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM3 462 3.48x48 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM3 463 3.49x49 A2A receptor 4UHR NTS1 receptor 4XEE
TM3 464 3.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM3 465 3.51x51 A2A receptor 4UHR OX2 receptor 5WS3
TM3 466 3.52x52 A2A receptor 4UHR - -
TM3 467 3.53x53 A2A receptor 4UHR S1P1 receptor 3V2Y
TM3 468 3.54x54 A2A receptor 4UHR A2A receptor 4UHR
TM3 469 3.55x55 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM3 470 3.56x56 A2A receptor 4UHR PAR1 3VW7
ICL2 471 34.50x50 A2A receptor 4UHR 5-HT1B receptor 4IAQ
ICL2 472 34.51x51 A2A receptor 4UHR C5a1 receptor 6C1R
ICL2 473 34.52x52 A2A receptor 4UHR D3 receptor 3PBL
ICL2 474 34.53x53 A2A receptor 4UHR - -
ICL2 475 34.54x54 A2A receptor 4UHR - -
ICL2 476 34.55x55 A2A receptor 4UHR - -
ICL2 477 34.56x56 A2A receptor 4UHR 5-HT1B receptor 5V54
ICL2 478 34.57x57 A2A receptor 4UHR P2Y1 receptor 4XNW
TM4 479 4.38x38 A2A receptor 4UHR FFA1 receptor 5TZY
TM4 480 4.39x39 A2A receptor 4UHR PAR1 3VW7
TM4 481 4.40x40 A2A receptor 4UHR μ receptor 6DDE
TM4 482 4.41x41 A2A receptor 4UHR Rhodopsin 5DYS
TM4 483 4.42x42 A2A receptor 4UHR A2A receptor 4UHR
TM4 484 4.43x43 A2A receptor 4UHR PAR2 5NDD
TM4 485 4.44x44 A2A receptor 4UHR δ receptor 4N6H
TM4 486 4.45x45 A2A receptor 4UHR A2A receptor 4UHR
TM4 487 4.46x46 A2A receptor 4UHR - -
TM4 488 4.47x47 A2A receptor 4UHR PAR2 5NDD
TM4 489 4.48x48 A2A receptor 4UHR H1 receptor 3RZE
TM4 490 4.49x49 A2A receptor 4UHR - -
TM4 491 4.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM4 492 4.51x51 A2A receptor 4UHR PAR2 5NDD
TM4 493 4.52x52 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM4 494 4.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM4 495 4.54x54 A2A receptor 4UHR κ receptor 4DJH
TM4 496 4.55x55 A2A receptor 4UHR PAR2 5NDD
TM4 497 4.56x56 A2A receptor 4UHR A2A receptor 4UHR
TM4 498 4.57x57 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM4 499 4.58x58 A2A receptor 4UHR - -
TM4 500 4.59x59 A2A receptor 4UHR FFA1 receptor 5TZY
TM4 501 4.60x60 A2A receptor 4UHR A2A receptor 4UHR
TM4 502 4.61x61 A2A receptor 4UHR PAR2 5NDD
TM4 503 4.62x62 A2A receptor 4UHR Rhodopsin 5DYS
ECL2 504 - - - -
ECL2 505 δ receptor 4N6H - -
ECL2 506 δ receptor 4N6H - -
ECL2 507 δ receptor 4N6H - -
ECL2 508 δ receptor 4N6H - -
ECL2 509 δ receptor 4N6H - -
ECL2 510 δ receptor 4N6H - -
ECL2 511 δ receptor 4N6H - -
ECL2 512 δ receptor 4N6H - -
ECL2 513 - - - -
ECL2 514 45.50x50 A2A receptor 4UHR A2A receptor 4UHR
ECL2 515 45.51x51 A2A receptor 4UHR PAF receptor 5ZKQ
ECL2 516 45.52x52 A2A receptor 4UHR - -
ECL2 517 - - - -
ECL2 518 PAR2 5NDD - -
ECL2 519 PAR2 5NDD - -
ECL2 520 PAR2 5NDD PAR2 5NDD
ECL2 521 PAR2 5NDD - -
ECL2 522 - - - -
TM5 523 5.35x35 Rhodopsin 5DYS AT1 receptor 4ZUD
TM5 524 5.36x36 A2A receptor 4UHR A1 receptor 5UEN
TM5 525 5.37x37 A2A receptor 4UHR β2-adrenoceptor 3SN6
TM5 526 5.38x38 A2A receptor 4UHR NTS1 receptor 4XES
TM5 527 5.39x39 A2A receptor 4UHR A2A receptor 4UHR
TM5 528 5.40x40 A2A receptor 4UHR NTS1 receptor 4XES
TM5 529 5.41x41 H1 receptor 3RZE PAR2 5NDD
TM5 530 5.42x42 H1 receptor 3RZE AT1 receptor 4ZUD
TM5 531 5.43x43 A2A receptor 4UHR PAF receptor 5ZKQ
TM5 532 5.44x44 A2A receptor 4UHR Y1 receptor 5ZBH
TM5 533 5.45x45 A2A receptor 4UHR PAR2 5NDD
TM5 534 5.46x46 S1P1 receptor 3V2Y FFA1 receptor 5TZY
TM5 535 5.47x47 S1P1 receptor 3V2Y LPA1 receptor 4Z35
TM5 536 5.48x48 A2A receptor 4UHR κ receptor 4DJH
TM5 537 5.49x49 A2A receptor 4UHR A2A receptor 4UHR
TM5 538 5.50x50 A2A receptor 4UHR - -
TM5 539 5.51x51 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM5 540 5.52x52 A2A receptor 4UHR PAR2 5NDD
TM5 541 5.53x53 A2A receptor 4UHR μ receptor 6DDE
TM5 542 5.54x54 A2A receptor 4UHR μ receptor 6DDE
TM5 543 5.55x55 A2A receptor 4UHR M1 receptor 5CXV
TM5 544 5.56x56 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM5 545 5.57x57 A2A receptor 4UHR μ receptor 6DDE
TM5 546 5.58x58 A2A receptor 4UHR A2A receptor 4UHR
TM5 547 5.59x59 A2A receptor 4UHR D2 receptor 6CM4
TM5 548 5.60x60 A2A receptor 4UHR H1 receptor 3RZE
TM5 549 5.61x61 A2A receptor 4UHR A2A receptor 4UHR
TM5 550 5.62x62 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM5 551 5.63x63 A2A receptor 4UHR Rhodopsin 5DYS
TM5 552 5.64x64 A2A receptor 4UHR A2A receptor 4UHR
TM5 553 5.65x65 A2A receptor 4UHR H1 receptor 3RZE
TM5 554 5.66x66 A2A receptor 4UHR A2A receptor 4UHR
TM5 555 5.67x67 A2A receptor 4UHR - -
ICL3 556 - - - -
ICL3 557 - - - -
ICL3 558 - - - -
ICL3 559 - - - -
TM6 560 6.26x26 A2A receptor 4UHR 5-HT2C receptor 6BQH
TM6 561 6.27x27 A2A receptor 4UHR FFA1 receptor 5TZY
TM6 562 6.28x28 A2A receptor 4UHR H1 receptor 3RZE
TM6 563 6.29x29 A2A receptor 4UHR A2A receptor 4UHR
TM6 564 6.30x30 A2A receptor 4UHR CB1 receptor 5XRA
TM6 565 6.31x31 A2A receptor 4UHR C5a1 receptor 6C1R
TM6 566 6.32x32 A2A receptor 4UHR PAR2 5NDD
TM6 567 6.33x33 A2A receptor 4UHR μ receptor 6DDE
TM6 568 6.34x34 A2A receptor 4UHR A2A receptor 4UHR
TM6 569 6.35x35 A2A receptor 4UHR A2A receptor 4UHR
TM6 570 6.36x36 A2A receptor 4UHR PAR2 5NDD
TM6 571 6.37x37 A2A receptor 4UHR PAF receptor 5ZKQ
TM6 572 6.38x38 A2A receptor 4UHR A2A receptor 4UHR
TM6 573 6.39x39 A2A receptor 4UHR A2A receptor 4UHR
TM6 574 6.40x40 A2A receptor 4UHR apelin receptor 5VBL
TM6 575 6.41x41 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM6 576 6.42x42 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM6 577 6.43x43 A2A receptor 4UHR P2Y1 receptor 4XNW
TM6 578 6.44x44 A2A receptor 4UHR - -
TM6 579 6.45x45 A2A receptor 4UHR PAR1 3VW7
TM6 580 6.46x46 A2A receptor 4UHR - -
TM6 581 6.47x47 A2A receptor 4UHR A2A receptor 4UHR
TM6 582 6.48x48 A2A receptor 4UHR - -
TM6 583 6.49x49 A2A receptor 4UHR δ receptor 4N6H
TM6 584 6.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM6 585 6.51x51 A2A receptor 4UHR μ receptor 6DDE
TM6 586 6.52x52 A2A receptor 4UHR OX2 receptor 5WS3
TM6 587 6.53x53 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM6 588 6.54x54 A2A receptor 4UHR H1 receptor 3RZE
TM6 589 6.55x55 A2A receptor 4UHR Rhodopsin 5DYS
TM6 590 6.56x56 A2A receptor 4UHR μ receptor 6DDE
TM6 591 6.57x57 A2A receptor 4UHR - -
TM6 592 6.58x58 A2A receptor 4UHR - -
TM6 593 6.59x59 A2A receptor 4UHR μ receptor 6DDE
TM6 594 6.60x60 A2A receptor 4UHR A2A receptor 4UHR
TM6 595 6.61x61 A2A receptor 4UHR - -
ECL3 596 - - - -
ECL3 597 Rhodopsin 5DYS - -
ECL3 598 Rhodopsin 5DYS - -
ECL3 599 Rhodopsin 5DYS - -
ECL3 600 - - - -
TM7 601 7.31x30 A2A receptor 4UHR - -
TM7 602 7.32x31 A2A receptor 4UHR μ receptor 6DDE
TM7 603 7.33x32 A2A receptor 4UHR apelin receptor 5VBL
TM7 604 7.34x33 A2A receptor 4UHR κ receptor 4DJH
TM7 605 7.35x34 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM7 606 7.36x35 A2A receptor 4UHR - -
TM7 607 7.37x36 A2A receptor 4UHR A2A receptor 4UHR
TM7 608 7.38x37 A2A receptor 4UHR β2-adrenoceptor 3SN6
TM7 609 7.39x38 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM7 610 7.40x39 A2A receptor 4UHR Y1 receptor 5ZBH
TM7 611 7.41x40 A2A receptor 4UHR Rhodopsin 5DYS
TM7 612 7.42x41 A2A receptor 4UHR - -
TM7 613 7.43x42 A2A receptor 4UHR - -
TM7 614 7.44x43 A2A receptor 4UHR PAR1 3VW7
TM7 615 7.45x45 A2A receptor 4UHR A2A receptor 4UHR
TM7 616 7.46x46 A2A receptor 4UHR A2A receptor 4UHR
TM7 617 7.47x47 A2A receptor 4UHR PAR2 5NDD
TM7 618 7.48x48 A2A receptor 4UHR OX2 receptor 5WS3
TM7 619 7.49x49 A2A receptor 4UHR A2A receptor 4UHR
TM7 620 7.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM7 621 7.51x51 A2A receptor 4UHR A2A receptor 4UHR
TM7 622 7.52x52 A2A receptor 4UHR μ receptor 6DDE
TM7 623 7.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM7 624 7.54x54 A2A receptor 4UHR A2A receptor 4UHR
TM7 625 7.55x55 A2A receptor 4UHR - -
TM7 626 7.56x56 A2A receptor 4UHR 5-HT2B receptor 4IB4
H8 627 8.47x47 A2A receptor 4UHR - -
H8 628 8.48x48 A2A receptor 4UHR 5-HT2B receptor 5TVN
H8 629 8.49x49 A2A receptor 4UHR 5-HT2B receptor 4IB4
H8 630 8.50x50 A2A receptor 4UHR A2A receptor 4UHR
H8 631 8.51x51 A2A receptor 4UHR Y1 receptor 5ZBH
H8 632 8.52x52 A2A receptor 4UHR κ receptor 4DJH
H8 633 8.53x53 A2A receptor 4UHR Y1 receptor 5ZBH
H8 634 8.54x54 A2A receptor 4UHR A2A receptor 4UHR
H8 635 8.55x55 A2A receptor 4UHR - -
H8 636 8.56x56 A2A receptor 4UHR M1 receptor 5CXV
H8 637 8.57x57 A2A receptor 4UHR 5-HT1B receptor 4IAQ
H8 638 8.58x58 A2A receptor 4UHR PAR2 5NDD
H8 639 8.59x59 A2A receptor 4UHR OX2 receptor 5WS3
C-term 640 A2A receptor 4UHR A2A receptor 4UHR
C-term 641 A2A receptor 4UHR A2A receptor 4UHR
C-term 642 A2A receptor 4UHR A2A receptor 4UHR
C-term 643 A2A receptor 4UHR A2A receptor 4UHR
C-term 644 A2A receptor 4UHR A2A receptor 4UHR
C-term 645 A2A receptor 4UHR A2A receptor 4UHR