MAS1 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate (Δ distance (Å): 7.11 docs)

VERSION

2018-07-10

MAIN TEMPLATE

PAR2 (sequence similarity: 39%) PDB: 5NDD

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 80.3 7.9 11.8
Side-chains 19.4 52.0 28.7

Number of backbone templates: 8
Number of rotamer templates: 38

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5NDD
5O9H
5VBL
4PXZ
6B73
4DJH
4ZUD
5TZY
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 25 PAR2 5NDD PAR2 5NDD
N-term 26 PAR2 5NDD PAR2 5NDD
N-term 27 PAR2 5NDD PAR2 5NDD
N-term 28 PAR2 5NDD PAR2 5NDD
N-term 29 PAR2 5NDD PAR2 5NDD
TM1 30 1.30x30 PAR2 5NDD - -
TM1 31 1.31x31 PAR2 5NDD P2Y1 receptor 4XNW
TM1 32 1.32x32 PAR2 5NDD Y1 receptor 5ZBH
TM1 33 1.33x33 PAR2 5NDD US28 4XT1
TM1 34 1.34x34 PAR2 5NDD κ receptor 4DJH
TM1 35 1.35x35 PAR2 5NDD PAR1 3VW7
TM1 36 1.36x36 PAR2 5NDD - -
TM1 37 1.37x37 PAR2 5NDD - -
TM1 38 1.38x38 PAR2 5NDD PAR2 5NDD
TM1 39 1.39x39 PAR2 5NDD 5-HT2C receptor 6BQH
TM1 40 1.40x40 PAR2 5NDD apelin receptor 5VBL
TM1 41 1.41x41 PAR2 5NDD M4 receptor 5DSG
TM1 42 1.42x42 PAR2 5NDD A2A receptor 4UHR
TM1 43 1.43x43 PAR2 5NDD M4 receptor 5DSG
TM1 44 1.44x44 PAR2 5NDD - -
TM1 45 1.45x45 PAR2 5NDD PAR2 5NDD
TM1 46 1.46x46 PAR2 5NDD μ receptor 6DDE
TM1 47 1.47x47 PAR2 5NDD P2Y1 receptor 4XNW
TM1 48 1.48x48 PAR2 5NDD NTS1 receptor 4XES
TM1 49 1.49x49 PAR2 5NDD CB1 receptor 5XRA
TM1 50 1.50x50 PAR2 5NDD PAR2 5NDD
TM1 51 1.51x51 PAR2 5NDD PAR2 5NDD
TM1 52 1.52x52 PAR2 5NDD - -
TM1 53 1.53x53 PAR2 5NDD Y1 receptor 5ZBH
TM1 54 1.54x54 PAR2 5NDD PAR2 5NDD
TM1 55 1.55x55 PAR2 5NDD PAR2 5NDD
TM1 56 1.56x56 PAR2 5NDD - -
TM1 57 1.57x57 PAR2 5NDD NTS1 receptor 4XES
TM1 58 1.58x58 PAR2 5NDD AT2 receptor 5UNG
TM1 59 1.59x59 PAR2 5NDD PAR2 5NDD
TM1 60 1.60x60 PAR2 5NDD PAR2 5NDD
ICL1 61 - - - -
ICL1 62 C5a1 receptor 5O9H - -
ICL1 63 - - - -
TM2 64 2.37x37 PAR2 5NDD A2A receptor 4UHR
TM2 65 2.38x38 PAR2 5NDD PAR2 5NDD
TM2 66 2.39x39 PAR2 5NDD P2Y12 receptor 4NTJ
TM2 67 2.40x40 PAR2 5NDD LPA6 receptor 5XSZ
TM2 68 2.41x41 PAR2 5NDD P2Y1 receptor 4XNW
TM2 69 2.42x42 PAR2 5NDD PAR2 5NDD
TM2 70 2.43x43 PAR2 5NDD μ receptor 6DDE
TM2 71 2.44x44 PAR2 5NDD β2-adrenoceptor 3SN6
TM2 72 2.45x45 PAR2 5NDD PAR1 3VW7
TM2 73 2.46x46 PAR2 5NDD PAR2 5NDD
TM2 74 2.47x47 PAR2 5NDD CXCR4 3ODU
TM2 75 2.48x48 PAR2 5NDD P2Y12 receptor 4NTJ
TM2 76 2.49x49 PAR2 5NDD PAR2 5NDD
TM2 77 2.50x50 PAR2 5NDD PAR2 5NDD
TM2 78 2.51x51 PAR2 5NDD A2A receptor 4UHR
TM2 79 2.52x52 PAR2 5NDD - -
TM2 80 2.53x53 PAR2 5NDD FFA1 receptor 5TZY
TM2 81 2.54x54 PAR2 5NDD NTS1 receptor 4XES
TM2 82 2.55x55 PAR2 5NDD Rhodopsin 5DYS
TM2 83 2.56x56 PAR2 5NDD OX2 receptor 5WS3
TM2 84 2.57x57 PAR2 5NDD A2A receptor 4UHR
TM2 85 2.58x58 PAR2 5NDD LPA1 receptor 4Z35
TM2 86 2.59x59 PAR2 5NDD 5-HT1B receptor 4IAQ
TM2 87 2.60x60 PAR2 5NDD P2Y1 receptor 4XNW
TM2 88 2.61x61 PAR2 5NDD κ receptor 4DJH
TM2 89 2.62x62 PAR2 5NDD CCR9 5LWE
TM2 90 2.63x63 PAR2 5NDD NOP receptor 5DHG
TM2 91 2.64x64 PAR2 5NDD μ receptor 6DDE
TM2 92 2.65x65 PAR2 5NDD P2Y12 receptor 4NTJ
TM2 93 2.66x66 PAR2 5NDD NOP receptor 5DHG
TM2 94 2.67x67 apelin receptor 5VBL apelin receptor 5VBL
ECL1 95 - - - -
ECL1 96 - - - -
ECL1 97 - - - -
TM3 98 3.18x18 P2Y12 receptor 4PXZ - -
TM3 99 3.19x19 P2Y12 receptor 4PXZ - -
TM3 100 3.20x20 P2Y12 receptor 4PXZ - -
TM3 101 3.21x21 PAR2 5NDD - -
TM3 102 3.22x22 PAR2 5NDD - -
TM3 103 3.23x23 PAR2 5NDD AT1 receptor 4ZUD
TM3 104 3.24x24 PAR2 5NDD A1 receptor 5UEN
TM3 105 3.25x25 PAR2 5NDD - -
TM3 106 3.26x26 PAR2 5NDD - -
TM3 107 3.27x27 PAR2 5NDD NOP receptor 5DHG
TM3 108 3.28x28 PAR2 5NDD PAR2 5NDD
TM3 109 3.29x29 PAR2 5NDD P2Y12 receptor 4NTJ
TM3 110 3.30x30 PAR2 5NDD FFA1 receptor 5TZY
TM3 111 3.31x31 PAR2 5NDD - -
TM3 112 3.32x32 PAR2 5NDD PAR2 5NDD
TM3 113 3.33x33 PAR2 5NDD A2A receptor 4UHR
TM3 114 3.34x34 PAR2 5NDD FFA1 receptor 5TZY
TM3 115 3.35x35 PAR2 5NDD CCR5 5UIW
TM3 116 3.36x36 PAR2 5NDD CCR2 5T1A
TM3 117 3.37x37 PAR2 5NDD M4 receptor 5DSG
TM3 118 3.38x38 PAR2 5NDD μ receptor 6DDE
TM3 119 3.39x39 PAR2 5NDD FFA1 receptor 5TZY
TM3 120 3.40x40 PAR2 5NDD US28 4XT1
TM3 121 3.41x41 PAR2 5NDD - -
TM3 122 3.42x42 PAR2 5NDD PAR1 3VW7
TM3 123 3.43x43 PAR2 5NDD PAR2 5NDD
TM3 124 3.44x44 PAR2 5NDD PAR2 5NDD
TM3 125 3.45x45 PAR2 5NDD A2A receptor 4UHR
TM3 126 3.46x46 PAR2 5NDD A2A receptor 4UHR
TM3 127 3.47x47 PAR2 5NDD PAR2 5NDD
TM3 128 3.48x48 PAR2 5NDD PAR2 5NDD
TM3 129 3.49x49 PAR2 5NDD NTS1 receptor 4XEE
TM3 130 3.50x50 PAR2 5NDD PAR2 5NDD
TM3 131 3.51x51 PAR2 5NDD - -
TM3 132 3.52x52 PAR2 5NDD PAR1 3VW7
TM3 133 3.53x53 PAR2 5NDD AT2 receptor 5UNG
TM3 134 3.54x54 PAR2 5NDD μ receptor 6DDE
TM3 135 3.55x55 PAR2 5NDD - -
TM3 136 3.56x56 PAR2 5NDD P2Y1 receptor 4XNW
ICL2 137 34.50x50 - - - -
ICL2 138 34.51x51 κ receptor 6B73 C5a1 receptor 6C1R
ICL2 139 34.52x52 κ receptor 6B73 C5a1 receptor 5O9H
ICL2 140 34.53x53 κ receptor 6B73 A2A receptor 4UHR
ICL2 141 34.54x54 κ receptor 6B73 LPA6 receptor 5XSZ
ICL2 142 34.55x55 κ receptor 6B73 - -
ICL2 143 34.56x56 κ receptor 6B73 - -
ICL2 144 34.57x57 - - - -
TM4 145 4.38x38 PAR2 5NDD - -
TM4 146 4.39x39 PAR2 5NDD P2Y1 receptor 4XNW
TM4 147 4.40x40 PAR2 5NDD - -
TM4 148 4.41x41 PAR2 5NDD AT2 receptor 5UNG
TM4 149 4.42x42 PAR2 5NDD FFA1 receptor 5TZY
TM4 150 4.43x43 PAR2 5NDD 5-HT1B receptor 4IAQ
TM4 151 4.44x44 PAR2 5NDD δ receptor 4N6H
TM4 152 4.45x45 PAR2 5NDD μ receptor 6DDE
TM4 153 4.46x46 PAR2 5NDD PAR1 3VW7
TM4 154 4.47x47 PAR2 5NDD A2A receptor 4UHR
TM4 155 4.48x48 PAR2 5NDD P2Y1 receptor 4XNW
TM4 156 4.49x49 PAR2 5NDD apelin receptor 5VBL
TM4 157 4.50x50 PAR2 5NDD PAR2 5NDD
TM4 158 4.51x51 PAR2 5NDD PAR1 3VW7
TM4 159 4.52x52 PAR2 5NDD PAR2 5NDD
TM4 160 4.53x53 PAR2 5NDD μ receptor 6DDE
TM4 161 4.54x54 PAR2 5NDD AT2 receptor 5UNG
TM4 162 4.55x55 PAR2 5NDD PAR2 5NDD
TM4 163 4.56x56 PAR2 5NDD PAR2 5NDD
TM4 164 4.57x57 κ receptor 4DJH κ receptor 4DJH
TM4 165 4.58x58 κ receptor 4DJH - -
TM4 166 4.59x59 κ receptor 4DJH apelin receptor 5VBL
TM4 167 4.60x60 PAR2 5NDD - -
TM4 168 4.61x61 PAR2 5NDD - -
TM4 169 4.62x62 PAR2 5NDD κ receptor 4DJH
TM4 170 4.63x63 PAR2 5NDD δ receptor 4N6H
TM4 171 4.64x64 AT1 receptor 4ZUD - -
ECL2 172 - - - -
ECL2 173 - - - -
ECL2 174 - - - -
ECL2 175 - - - -
ECL2 176 - - - -
ECL2 177 - - - -
ECL2 178 - - - -
ECL2 179 - - - -
ECL2 180 - - - -
ECL2 181 - - - -
ECL2 182 - - - -
ECL2 183 - - - -
ECL2 184 - - - -
TM5 185 5.34x35 PAR2 5NDD C5a1 receptor 5O9H
TM5 186 5.35x36 PAR2 5NDD PAR1 3VW7
TM5 187 5.36x37 PAR2 5NDD apelin receptor 5VBL
TM5 188 5.37x38 PAR2 5NDD P2Y1 receptor 4XNW
TM5 189 5.38x39 PAR2 5NDD PAF receptor 5ZKQ
TM5 190 5.39x40 PAR2 5NDD PAR2 5NDD
TM5 191 5.40x41 PAR2 5NDD μ receptor 6DDE
TM5 192 5.41x42 PAR2 5NDD β2-adrenoceptor 3SN6
TM5 193 5.42x43 PAR2 5NDD PAF receptor 5ZKQ
TM5 194 5.43x44 PAR2 5NDD C5a1 receptor 5O9H
TM5 195 5.44x45 PAR2 5NDD ETB receptor 5X93
TM5 196 5.45x46 PAR2 5NDD μ receptor 6DDE
TM5 197 5.46x461 PAR2 5NDD FFA1 receptor 5TZY
TM5 198 5.47x47 PAR2 5NDD A2A receptor 4UHR
TM5 199 5.48x48 PAR2 5NDD PAR1 3VW7
TM5 200 5.49x49 PAR2 5NDD 5-HT2B receptor 4IB4
TM5 201 5.50x50 PAR2 5NDD PAR2 5NDD
TM5 202 5.51x51 PAR2 5NDD A2A receptor 4UHR
TM5 203 5.52x52 PAR2 5NDD - -
TM5 204 5.53x53 PAR2 5NDD PAR2 5NDD
TM5 205 5.54x54 PAR2 5NDD P2Y12 receptor 4NTJ
TM5 206 5.55x55 PAR2 5NDD NTS1 receptor 4XES
TM5 207 5.56x56 PAR2 5NDD PAR2 5NDD
TM5 208 5.57x57 PAR2 5NDD 5-HT2B receptor 4IB4
TM5 209 5.58x58 PAR2 5NDD - -
TM5 210 5.59x59 PAR2 5NDD A2A receptor 4UHR
TM5 211 5.60x60 PAR2 5NDD NTS1 receptor 4XES
TM5 212 5.61x61 PAR2 5NDD A1 receptor 5UEN
TM5 213 5.62x62 PAR2 5NDD - -
TM5 214 5.63x63 PAR2 5NDD Y1 receptor 5ZBH
TM5 215 5.64x64 PAR2 5NDD μ receptor 6DDE
TM5 216 5.65x65 PAR2 5NDD - -
TM5 217 5.66x66 - - - -
TM5 218 5.67x67 - - - -
TM5 219 5.68x68 - - - -
ICL3 220 - - - -
ICL3 221 - - - -
ICL3 222 - - - -
TM6 223 6.30x30 PAR2 5NDD C5a1 receptor 6C1R
TM6 224 6.31x31 PAR2 5NDD - -
TM6 225 6.32x32 PAR2 5NDD PAR2 5NDD
TM6 226 6.33x33 PAR2 5NDD FFA1 receptor 5KW2
TM6 227 6.34x34 PAR2 5NDD - -
TM6 228 6.35x35 PAR2 5NDD PAR2 5NDD
TM6 229 6.36x36 PAR2 5NDD NTS1 receptor 4XES
TM6 230 6.37x37 PAR2 5NDD AT1 receptor 4ZUD
TM6 231 6.38x38 PAR2 5NDD AT1 receptor 4ZUD
TM6 232 6.39x39 PAR2 5NDD PAR2 5NDD
TM6 233 6.40x40 PAR2 5NDD PAR2 5NDD
TM6 234 6.41x41 PAR2 5NDD P2Y12 receptor 4NTJ
TM6 235 6.42x42 PAR2 5NDD NTS1 receptor 4XES
TM6 236 6.43x43 PAR2 5NDD LPA6 receptor 5XSZ
TM6 237 6.44x44 PAR2 5NDD μ receptor 6DDE
TM6 238 6.45x45 PAR2 5NDD FFA1 receptor 5TZY
TM6 239 6.46x46 AT1 receptor 4ZUD PAR1 3VW7
TM6 240 6.47x47 AT1 receptor 4ZUD C5a1 receptor 5O9H
TM6 241 6.48x48 PAR2 5NDD - -
TM6 242 6.49x49 PAR2 5NDD apelin receptor 5VBL
TM6 243 6.50x50 PAR2 5NDD PAR2 5NDD
TM6 244 6.51x51 PAR2 5NDD - -
TM6 245 6.52x52 PAR2 5NDD - -
TM6 246 6.53x53 PAR2 5NDD PAR2 5NDD
TM6 247 6.54x54 PAR2 5NDD PAR2 5NDD
TM6 248 6.55x55 PAR2 5NDD - -
TM6 249 6.56x56 PAR2 5NDD NTS1 receptor 4XES
TM6 250 6.57x57 PAR2 5NDD AT1 receptor 4ZUD
TM6 251 6.58x58 PAR2 5NDD P2Y12 receptor 4NTJ
TM6 252 6.59x59 PAR2 5NDD PAR2 5NDD
TM6 253 6.60x60 PAR2 5NDD - -
TM6 254 6.61x61 PAR2 5NDD - -
ECL3 255 - - - -
ECL3 256 FFA1 receptor 5TZY - -
ECL3 257 FFA1 receptor 5TZY - -
ECL3 258 - - - -
TM7 259 7.32x31 PAR2 5NDD FFA1 receptor 5TZY
TM7 260 7.33x32 PAR2 5NDD apelin receptor 5VBL
TM7 261 7.34x33 PAR2 5NDD PAR2 5NDD
TM7 262 7.35x34 PAR2 5NDD PAF receptor 5ZKQ
TM7 263 7.36x35 PAR2 5NDD μ receptor 6DDE
TM7 264 7.37x36 PAR2 5NDD 5-HT2B receptor 4IB4
TM7 265 7.38x37 PAR2 5NDD OX2 receptor 5WS3
TM7 266 7.39x38 PAR2 5NDD PAR2 5NDD
TM7 267 7.40x39 PAR2 5NDD AT2 receptor 5UNG
TM7 268 7.41x40 PAR2 5NDD C5a1 receptor 5O9H
TM7 269 7.42x41 PAR2 5NDD PAR2 5NDD
TM7 270 7.43x42 PAR2 5NDD PAR2 5NDD
TM7 271 7.44x43 PAR2 5NDD PAR1 3VW7
TM7 272 7.45x45 PAR2 5NDD PAR2 5NDD
TM7 273 7.46x46 PAR2 5NDD PAR2 5NDD
TM7 274 7.47x47 PAR2 5NDD κ receptor 4DJH
TM7 275 7.48x48 PAR2 5NDD OX2 receptor 5WS3
TM7 276 7.49x49 PAR2 5NDD μ receptor 6DDE
TM7 277 7.50x50 PAR2 5NDD PAR2 5NDD
TM7 278 7.51x51 PAR2 5NDD PAR2 5NDD
TM7 279 7.52x52 PAR2 5NDD A2A receptor 4UHR
TM7 280 7.53x53 PAR2 5NDD PAR2 5NDD
TM7 281 7.54x54 PAR2 5NDD P2Y1 receptor 4XNW
TM7 282 7.55x55 PAR2 5NDD PAR2 5NDD
TM7 283 7.56x56 PAR2 5NDD PAR2 5NDD
H8 284 8.47x47 PAR2 5NDD US28 4XT1
H8 285 8.48x48 PAR2 5NDD - -
H8 286 8.49x49 PAR2 5NDD P2Y12 receptor 4NTJ
H8 287 8.50x50 PAR2 5NDD - -
H8 288 8.51x51 PAR2 5NDD 5-HT1B receptor 4IAQ
H8 289 8.52x52 PAR2 5NDD H1 receptor 3RZE
H8 290 8.53x53 PAR2 5NDD - -
H8 291 8.54x54 PAR2 5NDD A2A receptor 4UHR
H8 292 8.55x55 PAR2 5NDD PAR2 5NDD
H8 293 8.56x56 PAR2 5NDD β2-adrenoceptor 3SN6
H8 294 8.57x57 PAR2 5NDD - -
H8 295 8.58x58 PAR2 5NDD PAR2 5NDD
H8 296 8.59x59 apelin receptor 5VBL CCR9 5LWE
H8 297 8.60x60 apelin receptor 5VBL - -
H8 298 8.61x61 apelin receptor 5VBL - -
C-term 299 - - - -
C-term 300 - - - -
C-term 301 - - - -
C-term 302 - - - -
C-term 303 - - - -