MC3 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate (Δ distance (Å): 6.31 docs)

VERSION

2018-07-10

MAIN TEMPLATE

A2A receptor (sequence similarity: 40%) PDB: 4UHR

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 78.4 11.7 10.0
Side-chains 24.4 50.5 25.1

Number of backbone templates: 7
Number of rotamer templates: 37

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3V2Y
4UHR
6CM4
4PXZ
5XRA
4DJH
4N6H
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 31 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
N-term 32 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
N-term 33 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
N-term 34 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
N-term 35 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM1 36 1.30x30 S1P1 receptor 3V2Y - -
TM1 37 1.31x31 S1P1 receptor 3V2Y P2Y1 receptor 4XNW
TM1 38 1.32x32 A2A receptor 4UHR - -
TM1 39 1.33x33 A2A receptor 4UHR Y1 receptor 5ZBH
TM1 40 1.34x34 A2A receptor 4UHR κ receptor 4DJH
TM1 41 1.35x35 A2A receptor 4UHR - -
TM1 42 1.36x36 A2A receptor 4UHR PAR1 3VW7
TM1 43 1.37x37 A2A receptor 4UHR - -
TM1 44 1.38x38 A2A receptor 4UHR A2A receptor 4UHR
TM1 45 1.39x39 A2A receptor 4UHR S1P1 receptor 3V2Y
TM1 46 1.40x40 A2A receptor 4UHR A2A receptor 4UHR
TM1 47 1.41x41 A2A receptor 4UHR M4 receptor 5DSG
TM1 48 1.42x42 A2A receptor 4UHR NTS1 receptor 4XES
TM1 49 1.43x43 A2A receptor 4UHR CB1 receptor 5XRA
TM1 50 1.44x44 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM1 51 1.45x45 A2A receptor 4UHR μ receptor 6DDE
TM1 52 1.46x46 A2A receptor 4UHR PAR1 3VW7
TM1 53 1.47x47 A2A receptor 4UHR PAR1 3VW7
TM1 54 1.48x48 A2A receptor 4UHR A2A receptor 4UHR
TM1 55 1.49x49 A2A receptor 4UHR S1P1 receptor 3V2Y
TM1 56 1.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM1 57 1.51x51 A2A receptor 4UHR PAR1 3VW7
TM1 58 1.52x52 A2A receptor 4UHR A2A receptor 4UHR
TM1 59 1.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM1 60 1.54x54 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM1 61 1.55x55 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM1 62 1.56x56 A2A receptor 4UHR A2A receptor 4UHR
TM1 63 1.57x57 A2A receptor 4UHR A2A receptor 4UHR
TM1 64 1.58x58 A2A receptor 4UHR μ receptor 6DDE
TM1 65 1.59x59 A2A receptor 4UHR 5-HT1B receptor 5V54
TM1 66 1.60x60 A2A receptor 4UHR A2A receptor 4UHR
ICL1 67 12.48x48 - - - -
ICL1 68 12.49x49 S1P1 receptor 3V2Y A2A receptor 4UHR
ICL1 69 12.50x50 S1P1 receptor 3V2Y A2A receptor 4UHR
ICL1 70 12.51x51 - - - -
TM2 71 2.37x37 A2A receptor 4UHR NTS1 receptor 4XEE
TM2 72 2.38x38 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM2 73 2.39x39 A2A receptor 4UHR S1P1 receptor 3V2Y
TM2 74 2.40x40 A2A receptor 4UHR S1P1 receptor 3V2Y
TM2 75 2.41x41 A2A receptor 4UHR - -
TM2 76 2.42x42 A2A receptor 4UHR A2A receptor 4UHR
TM2 77 2.43x43 A2A receptor 4UHR NTS1 receptor 4XES
TM2 78 2.44x44 A2A receptor 4UHR - -
TM2 79 2.45x45 A2A receptor 4UHR A2A receptor 4UHR
TM2 80 2.46x46 A2A receptor 4UHR A2A receptor 5WF5
TM2 81 2.47x47 A2A receptor 4UHR A2A receptor 4UHR
TM2 82 2.48x48 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM2 83 2.49x49 A2A receptor 4UHR A2A receptor 4UHR
TM2 84 2.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM2 85 2.51x51 A2A receptor 4UHR PAF receptor 5ZKQ
TM2 86 2.52x52 A2A receptor 4UHR A2A receptor 4UHR
TM2 87 2.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM2 88 2.54x54 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM2 89 2.55x55 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM2 90 2.56x56 S1P1 receptor 3V2Y FFA1 receptor 5TZY
TM2 91 2.57x57 A2A receptor 4UHR - -
TM2 92 2.58x58 A2A receptor 4UHR - -
TM2 93 2.59x59 A2A receptor 4UHR PAR2 5NDD
TM2 94 2.60x60 A2A receptor 4UHR NTS1 receptor 4XES
TM2 95 2.61x61 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM2 96 2.62x62 A2A receptor 4UHR CB1 receptor 5XRA
TM2 97 2.63x63 A2A receptor 4UHR - -
TM2 98 2.64x64 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM2 99 2.65x65 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM2 100 2.66x66 A2A receptor 4UHR M2 receptor 3UON
TM2 101 2.67x67 D2 receptor 6CM4 NTS1 receptor 4XES
ECL1 102 - - - -
ECL1 103 - - - -
ECL1 104 - - - -
ECL1 105 - - - -
ECL1 106 - - - -
ECL1 107 - - - -
ECL1 108 - - - -
ECL1 109 - - - -
TM3 110 3.18x18 P2Y12 receptor 4PXZ - -
TM3 111 3.19x19 P2Y12 receptor 4PXZ - -
TM3 112 3.20x20 P2Y12 receptor 4PXZ - -
TM3 113 3.21x21 A2A receptor 4UHR - -
TM3 114 3.22x22 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM3 115 3.23x23 A2A receptor 4UHR A2A receptor 4UHR
TM3 116 3.24x24 A2A receptor 4UHR P2Y1 receptor 4XNW
TM3 117 3.25x25 A2A receptor 4UHR - -
TM3 118 3.26x26 A2A receptor 4UHR PAR2 5NDD
TM3 119 3.27x27 A2A receptor 4UHR μ receptor 6DDE
TM3 120 3.28x28 A2A receptor 4UHR FFA1 receptor 5TZY
TM3 121 3.29x29 A2A receptor 4UHR - -
TM3 122 3.30x30 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM3 123 3.31x31 A2A receptor 4UHR H1 receptor 3RZE
TM3 124 3.32x32 A2A receptor 4UHR LPA1 receptor 4Z35
TM3 125 3.33x33 A2A receptor 4UHR Y1 receptor 5ZBH
TM3 126 3.34x34 A2A receptor 4UHR PAF receptor 5ZKQ
TM3 127 3.35x35 A2A receptor 4UHR CB1 receptor 5XRA
TM3 128 3.36x36 A2A receptor 4UHR P2Y1 receptor 4XNW
TM3 129 3.37x37 A2A receptor 4UHR - -
TM3 130 3.38x38 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM3 131 3.39x39 A2A receptor 4UHR A2A receptor 4UHR
TM3 132 3.40x40 A2A receptor 4UHR A2A receptor 4UHR
TM3 133 3.41x41 A2A receptor 4UHR US28 4XT1
TM3 134 3.42x42 A2A receptor 4UHR NTS1 receptor 4XES
TM3 135 3.43x43 A2A receptor 4UHR A2A receptor 4UHR
TM3 136 3.44x44 A2A receptor 4UHR A2A receptor 4UHR
TM3 137 3.45x45 A2A receptor 4UHR A2A receptor 4UHR
TM3 138 3.46x46 A2A receptor 4UHR A2A receptor 4UHR
TM3 139 3.47x47 A2A receptor 4UHR A2A receptor 4UHR
TM3 140 3.48x48 A2A receptor 4UHR μ receptor 6DDE
TM3 141 3.49x49 A2A receptor 4UHR A2A receptor 4UHR
TM3 142 3.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM3 143 3.51x51 A2A receptor 4UHR A2A receptor 4UHR
TM3 144 3.52x52 A2A receptor 4UHR 5-HT2C receptor 6BQH
TM3 145 3.53x53 A2A receptor 4UHR S1P1 receptor 3V2Y
TM3 146 3.54x54 A2A receptor 4UHR A2A receptor 4UHR
TM3 147 3.55x55 A2A receptor 4UHR LPA1 receptor 4Z35
TM3 148 3.56x56 A2A receptor 4UHR PAR1 3VW7
ICL2 149 34.50x50 - - - -
ICL2 150 34.51x51 CB1 receptor 5XRA CB1 receptor 5XRA
ICL2 151 34.52x52 CB1 receptor 5XRA A2A receptor 4UHR
ICL2 152 34.53x53 CB1 receptor 5XRA CB1 receptor 5XRA
ICL2 153 34.54x54 CB1 receptor 5XRA CCR9 5LWE
ICL2 154 34.55x55 CB1 receptor 5XRA β2-adrenoceptor 3SN6
ICL2 155 34.56x56 CB1 receptor 5XRA CB1 receptor 5XRA
ICL2 156 34.57x57 - - - -
TM4 157 4.38x38 A2A receptor 4UHR A2A receptor 4UHR
TM4 158 4.39x39 A2A receptor 4UHR CCR2 5T1A
TM4 159 4.40x40 A2A receptor 4UHR μ receptor 6DDE
TM4 160 4.41x41 A2A receptor 4UHR CB1 receptor 5TGZ
TM4 161 4.42x42 A2A receptor 4UHR A2A receptor 4UHR
TM4 162 4.43x43 A2A receptor 4UHR D4 receptor 5WIV
TM4 163 4.44x44 A2A receptor 4UHR - -
TM4 164 4.45x45 A2A receptor 4UHR PAF receptor 5ZKQ
TM4 165 4.46x46 A2A receptor 4UHR A2A receptor 4UHR
TM4 166 4.47x47 A2A receptor 4UHR μ receptor 6DDE
TM4 167 4.48x48 A2A receptor 4UHR NTS1 receptor 4XES
TM4 168 4.49x49 A2A receptor 4UHR NTS1 receptor 4XES
TM4 169 4.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM4 170 4.51x51 A2A receptor 4UHR A2A receptor 4UHR
TM4 171 4.52x52 A2A receptor 4UHR - -
TM4 172 4.53x53 A2A receptor 4UHR - -
TM4 173 4.54x54 A2A receptor 4UHR β2-adrenoceptor 3SN6
TM4 174 4.55x55 A2A receptor 4UHR P2Y1 receptor 4XNW
TM4 175 4.56x56 A2A receptor 4UHR Rhodopsin 5DYS
TM4 176 4.57x57 A2A receptor 4UHR A2A receptor 4UHR
TM4 177 4.58x58 A2A receptor 4UHR CB1 receptor 5XRA
TM4 178 4.59x59 A2A receptor 4UHR PAR1 3VW7
TM4 179 4.60x60 A2A receptor 4UHR PAF receptor 5ZKQ
TM4 180 4.61x61 A2A receptor 4UHR S1P1 receptor 3V2Y
TM4 181 4.62x62 A2A receptor 4UHR LPA1 receptor 4Z35
TM4 182 4.63x63 A2A receptor 4UHR P2Y1 receptor 4XNW
ECL2 183 - - - -
ECL2 184 - - - -
ECL2 185 - - - -
ECL2 186 - - - -
ECL2 187 - - - -
ECL2 188 - - - -
ECL2 189 - - - -
ECL2 190 - - - -
ECL2 191 - - - -
TM5 192 5.33x33 κ receptor 4DJH P2Y1 receptor 4XNW
TM5 193 5.34x34 κ receptor 4DJH OX2 receptor 5WS3
TM5 194 5.35x35 κ receptor 4DJH NTS1 receptor 4XES
TM5 195 5.36x36 A2A receptor 4UHR - -
TM5 196 5.37x37 A2A receptor 4UHR PAR2 5NDD
TM5 197 5.38x38 A2A receptor 4UHR κ receptor 4DJH
TM5 198 5.39x39 A2A receptor 4UHR FFA1 receptor 5TZY
TM5 199 5.40x40 A2A receptor 4UHR A2A receptor 4UHR
TM5 200 5.41x41 S1P1 receptor 3V2Y P2Y1 receptor 4XNW
TM5 201 5.42x42 S1P1 receptor 3V2Y Y1 receptor 5ZBH
TM5 202 5.43x43 A2A receptor 4UHR PAR2 5NDD
TM5 203 5.44x44 A2A receptor 4UHR US28 4XT1
TM5 204 5.45x45 A2A receptor 4UHR CB1 receptor 5XRA
TM5 205 5.46x46 S1P1 receptor 3V2Y BLT1 receptor 5X33
TM5 206 5.47x47 S1P1 receptor 3V2Y CXCR4 3ODU
TM5 207 5.48x48 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM5 208 5.49x49 A2A receptor 4UHR A2A receptor 4UHR
TM5 209 5.50x50 A2A receptor 4UHR - -
TM5 210 5.51x51 A2A receptor 4UHR NTS1 receptor 4XES
TM5 211 5.52x52 A2A receptor 4UHR PAR2 5NDD
TM5 212 5.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM5 213 5.54x54 A2A receptor 4UHR - -
TM5 214 5.55x55 A2A receptor 4UHR PAR2 5NDD
TM5 215 5.56x56 A2A receptor 4UHR - -
TM5 216 5.57x57 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM5 217 5.58x58 A2A receptor 4UHR - -
TM5 218 5.59x59 A2A receptor 4UHR PAR1 3VW7
TM5 219 5.60x60 A2A receptor 4UHR H1 receptor 3RZE
TM5 220 5.61x61 A2A receptor 4UHR - -
TM5 221 5.62x62 A2A receptor 4UHR μ receptor 6DDE
TM5 222 5.63x63 A2A receptor 4UHR A2A receptor 5IU4
TM5 223 5.64x64 A2A receptor 4UHR A2A receptor 4UHR
TM5 224 5.65x65 A2A receptor 4UHR μ receptor 6DDE
TM5 225 5.66x66 A2A receptor 4UHR - -
TM5 226 5.67x67 A2A receptor 4UHR - -
TM5 227 5.68x68 A2A receptor 4UHR Rhodopsin 5DYS
ICL3 228 - - - -
ICL3 229 - - - -
ICL3 230 - - - -
ICL3 231 - - - -
ICL3 232 - - - -
ICL3 233 - - - -
TM6 234 6.27x27 A2A receptor 4UHR Rhodopsin 5DYS
TM6 235 6.28x28 A2A receptor 4UHR FFA1 receptor 5TZY
TM6 236 6.29x29 A2A receptor 4UHR PAR1 3VW7
TM6 237 6.30x30 A2A receptor 4UHR - -
TM6 238 6.31x31 A2A receptor 4UHR LPA1 receptor 4Z35
TM6 239 6.32x32 A2A receptor 4UHR 5-HT1B receptor 4IAR
TM6 240 6.33x33 A2A receptor 4UHR NTS1 receptor 4XES
TM6 241 6.34x34 A2A receptor 4UHR A2A receptor 4UHR
TM6 242 6.35x35 A2A receptor 4UHR - -
TM6 243 6.36x36 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM6 244 6.37x37 A2A receptor 4UHR M4 receptor 5DSG
TM6 245 6.38x38 A2A receptor 4UHR - -
TM6 246 6.39x39 A2A receptor 4UHR A2A receptor 4UHR
TM6 247 6.40x40 A2A receptor 4UHR CXCR4 3ODU
TM6 248 6.41x41 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM6 249 6.42x42 A2A receptor 4UHR A2A receptor 4UHR
TM6 250 6.43x43 A2A receptor 4UHR μ receptor 6DDE
TM6 251 6.44x44 A2A receptor 4UHR A2A receptor 4UHR
TM6 252 6.45x45 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM6 253 6.46x46 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM6 254 6.47x47 A2A receptor 4UHR A2A receptor 4UHR
TM6 255 6.48x48 A2A receptor 4UHR A2A receptor 4UHR
TM6 256 6.49x49 A2A receptor 4UHR S1P1 receptor 3V2Y
TM6 257 6.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM6 258 6.51x51 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM6 259 6.52x52 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM6 260 6.53x53 A2A receptor 4UHR PAR2 5NDD
TM6 261 6.54x54 A2A receptor 4UHR - -
TM6 262 6.55x55 A2A receptor 4UHR PAR1 3VW7
TM6 263 6.56x56 A2A receptor 4UHR PAR2 5NDD
TM6 264 6.57x57 A2A receptor 4UHR S1P1 receptor 3V2Y
TM6 265 6.58x58 A2A receptor 4UHR H1 receptor 3RZE
TM6 266 6.59x59 A2A receptor 4UHR D2 receptor 6CM4
TM6 267 6.60x60 A2A receptor 4UHR Rhodopsin 5DYS
TM6 268 6.61x61 A2A receptor 4UHR A2A receptor 4UHR
ECL3 269 - - - -
ECL3 270 δ receptor 4N6H - -
ECL3 271 δ receptor 4N6H - -
ECL3 272 δ receptor 4N6H - -
ECL3 273 - - - -
TM7 274 7.28x27 CB1 receptor 5XRA - -
TM7 275 7.29x28 CB1 receptor 5XRA - -
TM7 276 7.30x29 CB1 receptor 5XRA - -
TM7 277 7.31x30 A2A receptor 4UHR - -
TM7 278 7.32x31 A2A receptor 4UHR μ receptor 6DDE
TM7 279 7.33x32 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM7 280 7.34x33 A2A receptor 4UHR - -
TM7 281 7.35x34 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM7 282 7.36x35 A2A receptor 4UHR M3 receptor 4U15
TM7 283 7.37x36 A2A receptor 4UHR - -
TM7 284 7.38x37 A2A receptor 4UHR - -
TM7 285 7.39x38 A2A receptor 4UHR PAR2 5NDD
TM7 286 7.40x39 A2A receptor 4UHR A2A receptor 4UHR
TM7 287 7.41x40 A2A receptor 4UHR A2A receptor 4UHR
TM7 288 7.42x41 A2A receptor 4UHR - -
TM7 289 7.43x42 A2A receptor 4UHR CCR2 5T1A
TM7 290 7.44x43 A2A receptor 4UHR US28 4XT1
TM7 291 7.45x45 A2A receptor 4UHR A2A receptor 4UHR
TM7 292 7.46x46 A2A receptor 4UHR A2A receptor 4UHR
TM7 293 7.47x47 A2A receptor 4UHR A2A receptor 4UHR
TM7 294 7.48x48 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM7 295 7.49x49 A2A receptor 4UHR - -
TM7 296 7.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM7 297 7.51x51 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM7 298 7.52x52 A2A receptor 4UHR A2A receptor 4UHR
TM7 299 7.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM7 300 7.54x54 A2A receptor 4UHR A2A receptor 4UHR
TM7 301 7.55x55 A2A receptor 4UHR PAR2 5NDD
TM7 302 7.56x56 A2A receptor 4UHR A2A receptor 4UHR
H8 303 8.47x47 A2A receptor 4UHR PAR2 5NDD
H8 304 8.48x48 A2A receptor 4UHR - -
H8 305 8.49x49 A2A receptor 4UHR A2A receptor 4UHR
H8 306 8.50x50 A2A receptor 4UHR CB1 receptor 5XRA
H8 307 8.51x51 A2A receptor 4UHR A2A receptor 4UHR
H8 308 8.52x52 A2A receptor 4UHR P2Y12 receptor 4NTJ
H8 309 8.53x53 A2A receptor 4UHR A2A receptor 4UHR
H8 310 8.54x54 A2A receptor 4UHR A2A receptor 4UHR
H8 311 8.55x55 A2A receptor 4UHR A2A receptor 4UHR
H8 312 8.56x56 A2A receptor 4UHR β2-adrenoceptor 3SN6
H8 313 8.57x57 A2A receptor 4UHR A2A receptor 4UHR
H8 314 8.58x58 A2A receptor 4UHR PAR2 5NDD
H8 315 8.59x59 A2A receptor 4UHR β2-adrenoceptor 3SN6
C-term 316 A2A receptor 4UHR A2A receptor 4UHR
C-term 317 A2A receptor 4UHR A2A receptor 4UHR
C-term 318 A2A receptor 4UHR A2A receptor 4UHR
C-term 319 A2A receptor 4UHR A2A receptor 4UHR
C-term 320 A2A receptor 4UHR A2A receptor 4UHR
C-term 321 A2A receptor 4UHR A2A receptor 4UHR