MC4 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate (Δ distance (Å): 6.31 docs)

VERSION

2018-07-10

MAIN TEMPLATE

A2A receptor (sequence similarity: 41%) PDB: 4UHR

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 80.3 12.1 7.6
Side-chains 24.9 51.6 23.5

Number of backbone templates: 7
Number of rotamer templates: 39

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3V2Y
4UHR
6CM4
4PXZ
5XRA
4DJH
4N6H
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 36 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
N-term 37 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
N-term 38 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
N-term 39 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
N-term 40 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM1 41 1.29x29 S1P1 receptor 3V2Y - -
TM1 42 1.30x30 S1P1 receptor 3V2Y - -
TM1 43 1.31x31 S1P1 receptor 3V2Y P2Y1 receptor 4XNW
TM1 44 1.32x32 A2A receptor 4UHR - -
TM1 45 1.33x33 A2A receptor 4UHR Y1 receptor 5ZBH
TM1 46 1.34x34 A2A receptor 4UHR A2A receptor 4UHR
TM1 47 1.35x35 A2A receptor 4UHR FFA1 receptor 5TZY
TM1 48 1.36x36 A2A receptor 4UHR PAR1 3VW7
TM1 49 1.37x37 A2A receptor 4UHR - -
TM1 50 1.38x38 A2A receptor 4UHR A2A receptor 4UHR
TM1 51 1.39x39 A2A receptor 4UHR S1P1 receptor 3V2Y
TM1 52 1.40x40 A2A receptor 4UHR FFA1 receptor 5TZY
TM1 53 1.41x41 A2A receptor 4UHR LPA1 receptor 4Z35
TM1 54 1.42x42 A2A receptor 4UHR NTS1 receptor 4XES
TM1 55 1.43x43 A2A receptor 4UHR CB1 receptor 5XRA
TM1 56 1.44x44 A2A receptor 4UHR A2A receptor 4UHR
TM1 57 1.45x45 A2A receptor 4UHR P2Y1 receptor 4XNW
TM1 58 1.46x46 A2A receptor 4UHR PAR1 3VW7
TM1 59 1.47x47 A2A receptor 4UHR PAR1 3VW7
TM1 60 1.48x48 A2A receptor 4UHR A2A receptor 4UHR
TM1 61 1.49x49 A2A receptor 4UHR S1P1 receptor 3V2Y
TM1 62 1.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM1 63 1.51x51 A2A receptor 4UHR PAR1 3VW7
TM1 64 1.52x52 A2A receptor 4UHR A2A receptor 4UHR
TM1 65 1.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM1 66 1.54x54 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM1 67 1.55x55 A2A receptor 4UHR PAR1 3VW7
TM1 68 1.56x56 A2A receptor 4UHR A2A receptor 4UHR
TM1 69 1.57x57 A2A receptor 4UHR S1P1 receptor 3V2Y
TM1 70 1.58x58 A2A receptor 4UHR NTS1 receptor 4XES
TM1 71 1.59x59 A2A receptor 4UHR OX2 receptor 5WS3
TM1 72 1.60x60 A2A receptor 4UHR A2A receptor 4UHR
ICL1 73 12.48x48 - - - -
ICL1 74 12.49x49 S1P1 receptor 3V2Y A2A receptor 4UHR
ICL1 75 12.50x50 S1P1 receptor 3V2Y A2A receptor 4UHR
ICL1 76 12.51x51 - - - -
TM2 77 2.37x37 A2A receptor 4UHR NTS1 receptor 4XEE
TM2 78 2.38x38 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM2 79 2.39x39 A2A receptor 4UHR S1P1 receptor 3V2Y
TM2 80 2.40x40 A2A receptor 4UHR S1P1 receptor 3V2Y
TM2 81 2.41x41 A2A receptor 4UHR - -
TM2 82 2.42x42 A2A receptor 4UHR A2A receptor 4UHR
TM2 83 2.43x43 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM2 84 2.44x44 A2A receptor 4UHR - -
TM2 85 2.45x45 A2A receptor 4UHR A2A receptor 4UHR
TM2 86 2.46x46 A2A receptor 4UHR A2A receptor 5WF5
TM2 87 2.47x47 A2A receptor 4UHR A2A receptor 4UHR
TM2 88 2.48x48 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM2 89 2.49x49 A2A receptor 4UHR A2A receptor 4UHR
TM2 90 2.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM2 91 2.51x51 A2A receptor 4UHR PAF receptor 5ZKQ
TM2 92 2.52x52 A2A receptor 4UHR A2A receptor 4UHR
TM2 93 2.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM2 94 2.54x54 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM2 95 2.55x55 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM2 96 2.56x56 S1P1 receptor 3V2Y FFA1 receptor 5TZY
TM2 97 2.57x57 A2A receptor 4UHR - -
TM2 98 2.58x58 A2A receptor 4UHR - -
TM2 99 2.59x59 A2A receptor 4UHR Rhodopsin 4ZWJ
TM2 100 2.60x60 A2A receptor 4UHR NTS1 receptor 4XES
TM2 101 2.61x61 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM2 102 2.62x62 A2A receptor 4UHR CB1 receptor 5XRA
TM2 103 2.63x63 A2A receptor 4UHR κ receptor 4DJH
TM2 104 2.64x64 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM2 105 2.65x65 A2A receptor 4UHR A2A receptor 4UHR
TM2 106 2.66x66 A2A receptor 4UHR NOP receptor 5DHG
TM2 107 2.67x67 D2 receptor 6CM4 - -
ECL1 108 - - - -
ECL1 109 - - - -
ECL1 110 - - - -
ECL1 111 - - - -
ECL1 112 - - - -
ECL1 113 - - - -
ECL1 114 - - - -
TM3 115 3.18x18 P2Y12 receptor 4PXZ - -
TM3 116 3.19x19 P2Y12 receptor 4PXZ - -
TM3 117 3.20x20 P2Y12 receptor 4PXZ - -
TM3 118 3.21x21 A2A receptor 4UHR S1P1 receptor 3V2Y
TM3 119 3.22x22 A2A receptor 4UHR LPA1 receptor 4Z35
TM3 120 3.23x23 A2A receptor 4UHR CB1 receptor 5XRA
TM3 121 3.24x24 A2A receptor 4UHR - -
TM3 122 3.25x25 A2A receptor 4UHR - -
TM3 123 3.26x26 A2A receptor 4UHR PAR2 5NDD
TM3 124 3.27x27 A2A receptor 4UHR PAR2 5NDD
TM3 125 3.28x28 A2A receptor 4UHR A2A receptor 4UHR
TM3 126 3.29x29 A2A receptor 4UHR - -
TM3 127 3.30x30 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM3 128 3.31x31 A2A receptor 4UHR Y1 receptor 5ZBH
TM3 129 3.32x32 A2A receptor 4UHR LPA1 receptor 4Z35
TM3 130 3.33x33 A2A receptor 4UHR Y1 receptor 5ZBH
TM3 131 3.34x34 A2A receptor 4UHR - -
TM3 132 3.35x35 A2A receptor 4UHR LPA1 receptor 4Z35
TM3 133 3.36x36 A2A receptor 4UHR P2Y1 receptor 4XNW
TM3 134 3.37x37 A2A receptor 4UHR - -
TM3 135 3.38x38 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM3 136 3.39x39 A2A receptor 4UHR A2A receptor 4UHR
TM3 137 3.40x40 A2A receptor 4UHR A2A receptor 4UHR
TM3 138 3.41x41 A2A receptor 4UHR US28 4XT1
TM3 139 3.42x42 A2A receptor 4UHR A2A receptor 4UHR
TM3 140 3.43x43 A2A receptor 4UHR A2A receptor 4UHR
TM3 141 3.44x44 A2A receptor 4UHR A2A receptor 4UHR
TM3 142 3.45x45 A2A receptor 4UHR NTS1 receptor 4XES
TM3 143 3.46x46 A2A receptor 4UHR A2A receptor 4UHR
TM3 144 3.47x47 A2A receptor 4UHR A2A receptor 4UHR
TM3 145 3.48x48 A2A receptor 4UHR μ receptor 6DDE
TM3 146 3.49x49 A2A receptor 4UHR A2A receptor 4UHR
TM3 147 3.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM3 148 3.51x51 A2A receptor 4UHR A2A receptor 4UHR
TM3 149 3.52x52 A2A receptor 4UHR M3 receptor 4U15
TM3 150 3.53x53 A2A receptor 4UHR S1P1 receptor 3V2Y
TM3 151 3.54x54 A2A receptor 4UHR A2A receptor 4UHR
TM3 152 3.55x55 A2A receptor 4UHR LPA1 receptor 4Z35
TM3 153 3.56x56 A2A receptor 4UHR PAR1 3VW7
ICL2 154 34.50x50 - - - -
ICL2 155 34.51x51 CB1 receptor 5XRA CB1 receptor 5XRA
ICL2 156 34.52x52 CB1 receptor 5XRA - -
ICL2 157 34.53x53 CB1 receptor 5XRA CB1 receptor 5XRA
ICL2 158 34.54x54 CB1 receptor 5XRA CCR9 5LWE
ICL2 159 34.55x55 CB1 receptor 5XRA C5a1 receptor 6C1R
ICL2 160 34.56x56 CB1 receptor 5XRA CB1 receptor 5XRA
ICL2 161 34.57x57 - - - -
TM4 162 4.38x38 A2A receptor 4UHR A2A receptor 4UHR
TM4 163 4.39x39 A2A receptor 4UHR CCR5 5UIW
TM4 164 4.40x40 A2A receptor 4UHR 5-HT1B receptor 5V54
TM4 165 4.41x41 A2A receptor 4UHR A2A receptor 4UHR
TM4 166 4.42x42 A2A receptor 4UHR LPA1 receptor 4Z35
TM4 167 4.43x43 A2A receptor 4UHR M3 receptor 4U15
TM4 168 4.44x44 A2A receptor 4UHR μ receptor 6DDE
TM4 169 4.45x45 A2A receptor 4UHR A2A receptor 4UHR
TM4 170 4.46x46 A2A receptor 4UHR A2A receptor 4UHR
TM4 171 4.47x47 A2A receptor 4UHR NTS1 receptor 4XES
TM4 172 4.48x48 A2A receptor 4UHR μ receptor 6DDE
TM4 173 4.49x49 A2A receptor 4UHR NTS1 receptor 4XES
TM4 174 4.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM4 175 4.51x51 A2A receptor 4UHR PAR1 3VW7
TM4 176 4.52x52 A2A receptor 4UHR NTS1 receptor 4XES
TM4 177 4.53x53 A2A receptor 4UHR - -
TM4 178 4.54x54 A2A receptor 4UHR - -
TM4 179 4.55x55 A2A receptor 4UHR P2Y1 receptor 4XNW
TM4 180 4.56x56 A2A receptor 4UHR Y1 receptor 5ZBH
TM4 181 4.57x57 A2A receptor 4UHR A2A receptor 4UHR
TM4 182 4.58x58 A2A receptor 4UHR κ receptor 4DJH
TM4 183 4.59x59 A2A receptor 4UHR FFA1 receptor 5TZY
TM4 184 4.60x60 A2A receptor 4UHR PAF receptor 5ZKQ
TM4 185 4.61x61 A2A receptor 4UHR S1P1 receptor 3V2Y
TM4 186 4.62x62 A2A receptor 4UHR PAF receptor 5ZKQ
TM4 187 4.63x63 A2A receptor 4UHR P2Y1 receptor 4XNW
ECL2 188 - - - -
ECL2 189 - - - -
ECL2 190 - - - -
ECL2 191 - - - -
ECL2 192 - - - -
ECL2 193 - - - -
ECL2 194 - - - -
ECL2 195 - - - -
ECL2 196 - - - -
TM5 197 5.33x33 κ receptor 4DJH P2Y1 receptor 4XNW
TM5 198 5.34x34 κ receptor 4DJH OX2 receptor 5WS3
TM5 199 5.35x35 κ receptor 4DJH NTS1 receptor 4XES
TM5 200 5.36x36 A2A receptor 4UHR - -
TM5 201 5.37x37 A2A receptor 4UHR PAR2 5NDD
TM5 202 5.38x38 A2A receptor 4UHR κ receptor 4DJH
TM5 203 5.39x39 A2A receptor 4UHR δ receptor 4N6H
TM5 204 5.40x40 A2A receptor 4UHR A2A receptor 4UHR
TM5 205 5.41x41 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM5 206 5.42x42 S1P1 receptor 3V2Y β2-adrenoceptor 3SN6
TM5 207 5.43x43 A2A receptor 4UHR PAR2 5NDD
TM5 208 5.44x44 A2A receptor 4UHR US28 4XT1
TM5 209 5.45x45 A2A receptor 4UHR - -
TM5 210 5.46x46 S1P1 receptor 3V2Y PAF receptor 5ZKQ
TM5 211 5.47x47 S1P1 receptor 3V2Y CCR5 5UIW
TM5 212 5.48x48 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM5 213 5.49x49 A2A receptor 4UHR A2A receptor 4UHR
TM5 214 5.50x50 A2A receptor 4UHR - -
TM5 215 5.51x51 A2A receptor 4UHR NTS1 receptor 4XES
TM5 216 5.52x52 A2A receptor 4UHR PAR2 5NDD
TM5 217 5.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM5 218 5.54x54 A2A receptor 4UHR A2A receptor 4UHR
TM5 219 5.55x55 A2A receptor 4UHR PAR2 5NDD
TM5 220 5.56x56 A2A receptor 4UHR - -
TM5 221 5.57x57 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM5 222 5.58x58 A2A receptor 4UHR - -
TM5 223 5.59x59 A2A receptor 4UHR D2 receptor 6CM4
TM5 224 5.60x60 A2A receptor 4UHR H1 receptor 3RZE
TM5 225 5.61x61 A2A receptor 4UHR - -
TM5 226 5.62x62 A2A receptor 4UHR μ receptor 6DDE
TM5 227 5.63x63 A2A receptor 4UHR A2A receptor 5IU4
TM5 228 5.64x64 A2A receptor 4UHR D2 receptor 6CM4
TM5 229 5.65x65 A2A receptor 4UHR μ receptor 6DDE
TM5 230 5.66x66 A2A receptor 4UHR - -
TM5 231 5.67x67 A2A receptor 4UHR - -
ICL3 232 A2A receptor 4UHR - -
ICL3 233 A2A receptor 4UHR - -
ICL3 234 A2A receptor 4UHR - -
ICL3 235 A2A receptor 4UHR - -
ICL3 236 A2A receptor 4UHR - -
TM6 237 6.27x27 A2A receptor 4UHR Rhodopsin 5DYS
TM6 238 6.28x28 A2A receptor 4UHR A1 receptor 6D9H
TM6 239 6.29x29 A2A receptor 4UHR NTS1 receptor 4XES
TM6 240 6.30x30 A2A receptor 4UHR S1P1 receptor 3V2Y
TM6 241 6.31x31 A2A receptor 4UHR LPA1 receptor 4Z35
TM6 242 6.32x32 A2A receptor 4UHR 5-HT1B receptor 4IAR
TM6 243 6.33x33 A2A receptor 4UHR NTS1 receptor 4XES
TM6 244 6.34x34 A2A receptor 4UHR A2A receptor 4UHR
TM6 245 6.35x35 A2A receptor 4UHR PAR2 5NDD
TM6 246 6.36x36 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM6 247 6.37x37 A2A receptor 4UHR A2A receptor 4UHR
TM6 248 6.38x38 A2A receptor 4UHR - -
TM6 249 6.39x39 A2A receptor 4UHR A2A receptor 4UHR
TM6 250 6.40x40 A2A receptor 4UHR ETB receptor 5X93
TM6 251 6.41x41 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM6 252 6.42x42 A2A receptor 4UHR A2A receptor 4UHR
TM6 253 6.43x43 A2A receptor 4UHR μ receptor 6DDE
TM6 254 6.44x44 A2A receptor 4UHR A2A receptor 4UHR
TM6 255 6.45x45 A2A receptor 4UHR NTS1 receptor 4XES
TM6 256 6.46x46 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM6 257 6.47x47 A2A receptor 4UHR A2A receptor 4UHR
TM6 258 6.48x48 A2A receptor 4UHR A2A receptor 4UHR
TM6 259 6.49x49 A2A receptor 4UHR S1P1 receptor 3V2Y
TM6 260 6.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM6 261 6.51x51 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM6 262 6.52x52 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM6 263 6.53x53 A2A receptor 4UHR PAR2 5NDD
TM6 264 6.54x54 A2A receptor 4UHR - -
TM6 265 6.55x55 A2A receptor 4UHR PAR1 3VW7
TM6 266 6.56x56 A2A receptor 4UHR μ receptor 6DDE
TM6 267 6.57x57 A2A receptor 4UHR A2A receptor 4UHR
TM6 268 6.58x58 A2A receptor 4UHR P2Y12 receptor 4NTJ
TM6 269 6.59x59 A2A receptor 4UHR D2 receptor 6CM4
TM6 270 6.60x60 A2A receptor 4UHR PAR1 3VW7
TM6 271 6.61x61 A2A receptor 4UHR A2A receptor 4UHR
ECL3 272 - - - -
ECL3 273 δ receptor 4N6H - -
ECL3 274 δ receptor 4N6H - -
ECL3 275 δ receptor 4N6H - -
ECL3 276 - - - -
TM7 277 7.28x27 CB1 receptor 5XRA - -
TM7 278 7.29x28 CB1 receptor 5XRA - -
TM7 279 7.30x29 CB1 receptor 5XRA - -
TM7 280 7.31x30 A2A receptor 4UHR - -
TM7 281 7.32x31 A2A receptor 4UHR apelin receptor 5VBL
TM7 282 7.33x32 A2A receptor 4UHR FFA1 receptor 5TZY
TM7 283 7.34x33 A2A receptor 4UHR - -
TM7 284 7.35x34 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM7 285 7.36x35 A2A receptor 4UHR M3 receptor 4U15
TM7 286 7.37x36 A2A receptor 4UHR A2A receptor 4UHR
TM7 287 7.38x37 A2A receptor 4UHR - -
TM7 288 7.39x38 A2A receptor 4UHR PAR2 5NDD
TM7 289 7.40x39 A2A receptor 4UHR FFA1 receptor 5TZY
TM7 290 7.41x40 A2A receptor 4UHR A2A receptor 4UHR
TM7 291 7.42x41 A2A receptor 4UHR - -
TM7 292 7.43x42 A2A receptor 4UHR CCR5 5UIW
TM7 293 7.44x43 A2A receptor 4UHR US28 4XT1
TM7 294 7.45x45 A2A receptor 4UHR A2A receptor 4UHR
TM7 295 7.46x46 A2A receptor 4UHR A2A receptor 4UHR
TM7 296 7.47x47 A2A receptor 4UHR Rhodopsin 4ZWJ
TM7 297 7.48x48 A2A receptor 4UHR 5-HT1B receptor 4IAQ
TM7 298 7.49x49 A2A receptor 4UHR - -
TM7 299 7.50x50 A2A receptor 4UHR A2A receptor 4UHR
TM7 300 7.51x51 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM7 301 7.52x52 A2A receptor 4UHR A2A receptor 4UHR
TM7 302 7.53x53 A2A receptor 4UHR A2A receptor 4UHR
TM7 303 7.54x54 A2A receptor 4UHR A2A receptor 4UHR
TM7 304 7.55x55 A2A receptor 4UHR 5-HT2B receptor 4IB4
TM7 305 7.56x56 A2A receptor 4UHR A2A receptor 4UHR
H8 306 8.47x47 A2A receptor 4UHR PAR2 5NDD
H8 307 8.48x48 A2A receptor 4UHR A1 receptor 5UEN
H8 308 8.49x49 A2A receptor 4UHR A2A receptor 4UHR
H8 309 8.50x50 A2A receptor 4UHR CB1 receptor 5XRA
H8 310 8.51x51 A2A receptor 4UHR A2A receptor 4UHR
H8 311 8.52x52 A2A receptor 4UHR M2 receptor 3UON
H8 312 8.53x53 A2A receptor 4UHR A2A receptor 4UHR
H8 313 8.54x54 A2A receptor 4UHR A2A receptor 4UHR
H8 314 8.55x55 A2A receptor 4UHR PAR2 5NDD
H8 315 8.56x56 A2A receptor 4UHR β2-adrenoceptor 3SN6
H8 316 8.57x57 A2A receptor 4UHR A2A receptor 4UHR
H8 317 8.58x58 A2A receptor 4UHR A2A receptor 4UHR
H8 318 8.59x59 A2A receptor 4UHR β2-adrenoceptor 3SN6
C-term 319 A2A receptor 4UHR A2A receptor 4UHR
C-term 320 A2A receptor 4UHR A2A receptor 4UHR
C-term 321 A2A receptor 4UHR A2A receptor 4UHR
C-term 322 A2A receptor 4UHR A2A receptor 4UHR
C-term 323 A2A receptor 4UHR A2A receptor 4UHR
C-term 324 A2A receptor 4UHR A2A receptor 4UHR