MC5 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 8.06 docs)

VERSION

2018-07-10

MAIN TEMPLATE

CB1 receptor (sequence similarity: 42%) PDB: 5XRA

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 77.8 9.4 12.8
Side-chains 20.5 51.7 27.8

Number of backbone templates: 6
Number of rotamer templates: 39

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5XRA
4Z35
4PXZ
4UHR
4DJH
4N6H
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 29 CB1 receptor 5XRA CB1 receptor 5XRA
N-term 30 CB1 receptor 5XRA CB1 receptor 5XRA
N-term 31 CB1 receptor 5XRA CB1 receptor 5XRA
N-term 32 CB1 receptor 5XRA CB1 receptor 5XRA
N-term 33 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 34 1.30x30 CB1 receptor 5XRA - -
TM1 35 1.31x31 CB1 receptor 5XRA - -
TM1 36 1.32x32 CB1 receptor 5XRA M4 receptor 5DSG
TM1 37 1.33x33 CB1 receptor 5XRA - -
TM1 38 1.34x34 CB1 receptor 5XRA κ receptor 6B73
TM1 39 1.35x35 CB1 receptor 5XRA D4 receptor 5WIV
TM1 40 1.36x36 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM1 41 1.37x37 CB1 receptor 5XRA - -
TM1 42 1.38x38 CB1 receptor 5XRA A2A receptor 5G53
TM1 43 1.39x39 CB1 receptor 5XRA LPA6 receptor 5XSZ
TM1 44 1.40x40 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 45 1.41x41 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 46 1.42x42 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 47 1.43x43 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 48 1.44x44 CB1 receptor 5XRA A2A receptor 5G53
TM1 49 1.45x45 CB1 receptor 5XRA AT2 receptor 5UNG
TM1 50 1.46x46 CB1 receptor 5XRA A1 receptor 6D9H
TM1 51 1.47x47 CB1 receptor 5XRA κ receptor 6B73
TM1 52 1.48x48 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 53 1.49x49 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 54 1.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 55 1.51x51 CB1 receptor 5XRA M2 receptor 4MQT
TM1 56 1.52x52 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 57 1.53x53 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 58 1.54x54 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM1 59 1.55x55 CB1 receptor 5XRA - -
TM1 60 1.56x56 CB1 receptor 5XRA A2A receptor 5G53
TM1 61 1.57x57 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 62 1.58x58 CB1 receptor 5XRA μ receptor 5C1M
TM1 63 1.59x59 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM1 64 1.60x60 CB1 receptor 5XRA - -
ICL1 65 12.48x48 - - - -
ICL1 66 12.49x49 LPA1 receptor 4Z35 A2A receptor 5G53
ICL1 67 12.50x50 LPA1 receptor 4Z35 A2A receptor 5G53
ICL1 68 12.51x51 - - - -
TM2 69 2.37x37 LPA1 receptor 4Z35 CXCR4 3ODU
TM2 70 2.38x38 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM2 71 2.39x39 LPA1 receptor 4Z35 S1P1 receptor 3V2Y
TM2 72 2.40x40 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 73 2.41x41 CB1 receptor 5XRA - -
TM2 74 2.42x42 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 75 2.43x43 CB1 receptor 5XRA A2A receptor 5G53
TM2 76 2.44x44 CB1 receptor 5XRA - -
TM2 77 2.45x45 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 78 2.46x46 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 79 2.47x47 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 80 2.48x48 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 81 2.49x49 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 82 2.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 83 2.51x51 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM2 84 2.52x52 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 85 2.53x53 CB1 receptor 5XRA A2A receptor 5G53
TM2 86 2.54x54 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 87 2.55x55 CB1 receptor 5XRA - -
TM2 88 2.56x56 CB1 receptor 5XRA M2 receptor 4MQT
TM2 89 2.57x57 CB1 receptor 5XRA - -
TM2 90 2.58x58 CB1 receptor 5XRA - -
TM2 91 2.59x59 CB1 receptor 5XRA D2 receptor 6CM4
TM2 92 2.60x60 CB1 receptor 5XRA NTS1 receptor 5T04
TM2 93 2.61x61 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM2 94 2.62x62 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 95 2.63x63 CB1 receptor 5XRA 5-HT2B receptor 5TUD
ECL1 96 - - - -
ECL1 97 - - - -
ECL1 98 - - - -
ECL1 99 - - - -
ECL1 100 - - - -
ECL1 101 - - - -
ECL1 102 - - - -
ECL1 103 - - - -
ECL1 104 - - - -
ECL1 105 - - - -
ECL1 106 - - - -
ECL1 107 - - - -
TM3 108 3.18x18 P2Y12 receptor 4PXZ - -
TM3 109 3.19x19 P2Y12 receptor 4PXZ - -
TM3 110 3.20x20 P2Y12 receptor 4PXZ - -
TM3 111 3.21x21 CB1 receptor 5XRA - -
TM3 112 3.22x22 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 113 3.23x23 CB1 receptor 5XRA A2A receptor 5G53
TM3 114 3.24x24 CB1 receptor 5XRA - -
TM3 115 3.25x25 CB1 receptor 5XRA - -
TM3 116 3.26x26 CB1 receptor 5XRA Rhodopsin 5DYS
TM3 117 3.27x27 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM3 118 3.28x28 CB1 receptor 5XRA AT2 receptor 5UNG
TM3 119 3.29x29 CB1 receptor 5XRA - -
TM3 120 3.30x30 CB1 receptor 5XRA κ receptor 6B73
TM3 121 3.31x31 CB1 receptor 5XRA H1 receptor 3RZE
TM3 122 3.32x32 CB1 receptor 5XRA LPA1 receptor 4Z35
TM3 123 3.33x33 CB1 receptor 5XRA Y1 receptor 5ZBH
TM3 124 3.34x34 CB1 receptor 5XRA A1 receptor 6D9H
TM3 125 3.35x35 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 126 3.36x36 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM3 127 3.37x37 CB1 receptor 5XRA - -
TM3 128 3.38x38 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 129 3.39x39 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 130 3.40x40 CB1 receptor 5XRA - -
TM3 131 3.41x41 CB1 receptor 5XRA US28 4XT1
TM3 132 3.42x42 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 133 3.43x43 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 134 3.44x44 CB1 receptor 5XRA A2A receptor 5G53
TM3 135 3.45x45 CB1 receptor 5XRA A2A receptor 5G53
TM3 136 3.46x46 CB1 receptor 5XRA A2A receptor 5G53
TM3 137 3.47x47 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 138 3.48x48 CB1 receptor 5XRA κ receptor 6B73
TM3 139 3.49x49 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 140 3.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 141 3.51x51 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 142 3.52x52 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM3 143 3.53x53 CB1 receptor 5XRA LPA1 receptor 4Z35
TM3 144 3.54x54 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 145 3.55x55 CB1 receptor 5XRA LPA1 receptor 4Z35
TM3 146 3.56x56 CB1 receptor 5XRA LPA6 receptor 5XSZ
ICL2 147 34.50x50 - - - -
ICL2 148 34.51x51 A2A receptor 4UHR A2A receptor 4UHR
ICL2 149 34.52x52 A2A receptor 4UHR A2A receptor 4UHR
ICL2 150 34.53x53 A2A receptor 4UHR A2A receptor 4UHR
ICL2 151 34.54x54 A2A receptor 4UHR CCR9 5LWE
ICL2 152 34.55x55 A2A receptor 4UHR D3 receptor 3PBL
ICL2 153 34.56x56 A2A receptor 4UHR CB1 receptor 5XRA
ICL2 154 34.57x57 - - - -
TM4 155 4.38x38 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 156 4.39x39 CB1 receptor 5XRA OX2 receptor 5WS3
TM4 157 4.40x40 CB1 receptor 5XRA μ receptor 5C1M
TM4 158 4.41x41 CB1 receptor 5XRA A2A receptor 5G53
TM4 159 4.42x42 CB1 receptor 5XRA CCR9 5LWE
TM4 160 4.43x43 CB1 receptor 5XRA M2 receptor 4MQT
TM4 161 4.44x44 CB1 receptor 5XRA NOP receptor 5DHG
TM4 162 4.45x45 CB1 receptor 5XRA A2A receptor 5G53
TM4 163 4.46x46 CB1 receptor 5XRA A2A receptor 5G53
TM4 164 4.47x47 CB1 receptor 5XRA A2A receptor 5G53
TM4 165 4.48x48 CB1 receptor 5XRA A1 receptor 6D9H
TM4 166 4.49x49 CB1 receptor 5XRA κ receptor 6B73
TM4 167 4.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 168 4.51x51 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM4 169 4.52x52 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM4 170 4.53x53 CB1 receptor 5XRA - -
TM4 171 4.54x54 CB1 receptor 5XRA - -
TM4 172 4.55x55 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM4 173 4.56x56 CB1 receptor 5XRA Rhodopsin 5DYS
TM4 174 4.57x57 CB1 receptor 5XRA A2A receptor 5G53
TM4 175 4.58x58 CB1 receptor 5XRA κ receptor 6B73
TM4 176 4.59x59 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM4 177 4.60x60 CB1 receptor 5XRA PAF receptor 5ZKP
TM4 178 4.61x61 CB1 receptor 5XRA κ receptor 6B73
TM4 179 4.62x62 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 180 4.63x63 CB1 receptor 5XRA AT2 receptor 5UNG
ECL2 181 - - - -
ECL2 182 - - - -
ECL2 183 - - - -
ECL2 184 - - - -
ECL2 185 - - - -
ECL2 186 - - - -
ECL2 187 - - - -
ECL2 188 - - - -
ECL2 189 - - - -
TM5 190 5.33x33 κ receptor 4DJH P2Y1 receptor 4XNW
TM5 191 5.34x34 κ receptor 4DJH OX2 receptor 5WS3
TM5 192 5.35x35 κ receptor 4DJH P2Y1 receptor 4XNW
TM5 193 5.36x36 CB1 receptor 5XRA - -
TM5 194 5.37x37 CB1 receptor 5XRA P2Y1 receptor 4XNW
TM5 195 5.38x38 CB1 receptor 5XRA κ receptor 6B73
TM5 196 5.39x39 CB1 receptor 5XRA FFA1 receptor 5TZY
TM5 197 5.40x40 CB1 receptor 5XRA A2A receptor 5G53
TM5 198 5.41x41 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM5 199 5.42x42 CB1 receptor 5XRA CB1 receptor 5XRA
TM5 200 5.43x43 CB1 receptor 5XRA US28 4XT1
TM5 201 5.44x44 CB1 receptor 5XRA Y1 receptor 5ZBH
TM5 202 5.45x45 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM5 203 5.46x46 CB1 receptor 5XRA PAF receptor 5ZKP
TM5 204 5.47x47 CB1 receptor 5XRA CXCR4 3ODU
TM5 205 5.48x48 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM5 206 5.49x49 CB1 receptor 5XRA κ receptor 6B73
TM5 207 5.50x50 CB1 receptor 5XRA - -
TM5 208 5.51x51 CB1 receptor 5XRA NTS1 receptor 5T04
TM5 209 5.52x52 CB1 receptor 5XRA PAR2 5NDD
TM5 210 5.53x53 CB1 receptor 5XRA A2A receptor 5G53
TM5 211 5.54x54 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM5 212 5.55x55 CB1 receptor 5XRA AT2 receptor 5UNG
TM5 213 5.56x56 CB1 receptor 5XRA - -
TM5 214 5.57x57 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM5 215 5.58x58 CB1 receptor 5XRA - -
TM5 216 5.59x59 CB1 receptor 5XRA PAR1 3VW7
TM5 217 5.60x60 CB1 receptor 5XRA H1 receptor 3RZE
TM5 218 5.61x61 CB1 receptor 5XRA - -
TM5 219 5.62x62 CB1 receptor 5XRA κ receptor 6B73
TM5 220 5.63x63 CB1 receptor 5XRA A2A receptor 5IU4
TM5 221 5.64x64 CB1 receptor 5XRA A2A receptor 5G53
TM5 222 5.65x65 CB1 receptor 5XRA κ receptor 6B73
TM5 223 5.66x66 CB1 receptor 5XRA - -
TM5 224 5.67x67 CB1 receptor 5XRA - -
ICL3 225 - - - -
ICL3 226 - - - -
ICL3 227 - - - -
ICL3 228 - - - -
ICL3 229 - - - -
TM6 230 6.27x27 LPA1 receptor 4Z35 Rhodopsin 5DYS
TM6 231 6.28x28 LPA1 receptor 4Z35 μ receptor 6DDF
TM6 232 6.29x29 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM6 233 6.30x30 CB1 receptor 5XRA C5a1 receptor 6C1R
TM6 234 6.31x31 CB1 receptor 5XRA LPA1 receptor 4Z35
TM6 235 6.32x32 CB1 receptor 5XRA AT2 receptor 5UNG
TM6 236 6.33x33 CB1 receptor 5XRA NTS1 receptor 5T04
TM6 237 6.34x34 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 238 6.35x35 CB1 receptor 5XRA - -
TM6 239 6.36x36 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 240 6.37x37 CB1 receptor 5XRA κ receptor 6B73
TM6 241 6.38x38 CB1 receptor 5XRA - -
TM6 242 6.39x39 CB1 receptor 5XRA - -
TM6 243 6.40x40 CB1 receptor 5XRA CXCR4 3ODU
TM6 244 6.41x41 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 245 6.42x42 CB1 receptor 5XRA A2A receptor 5G53
TM6 246 6.43x43 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 247 6.44x44 CB1 receptor 5XRA A2A receptor 5G53
TM6 248 6.45x45 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM6 249 6.46x46 CB1 receptor 5XRA κ receptor 6B73
TM6 250 6.47x47 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 251 6.48x48 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 252 6.49x49 CB1 receptor 5XRA M2 receptor 4MQT
TM6 253 6.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 254 6.51x51 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM6 255 6.52x52 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM6 256 6.53x53 CB1 receptor 5XRA US28 4XT1
TM6 257 6.54x54 CB1 receptor 5XRA - -
TM6 258 6.55x55 CB1 receptor 5XRA LPA6 receptor 5XSZ
TM6 259 6.56x56 CB1 receptor 5XRA P2Y1 receptor 4XNW
TM6 260 6.57x57 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM6 261 6.58x58 CB1 receptor 5XRA 5-HT1B receptor 4IAQ
TM6 262 6.59x59 CB1 receptor 5XRA A1 receptor 6D9H
TM6 263 6.60x60 CB1 receptor 5XRA PAR1 3VW7
TM6 264 6.61x61 CB1 receptor 5XRA A2A receptor 5G53
ECL3 265 - - - -
ECL3 266 δ receptor 4N6H - -
ECL3 267 δ receptor 4N6H - -
ECL3 268 δ receptor 4N6H - -
ECL3 269 - - - -
TM7 270 7.28x27 CB1 receptor 5XRA - -
TM7 271 7.29x28 CB1 receptor 5XRA LPA6 receptor 5XSZ
TM7 272 7.30x29 CB1 receptor 5XRA CCR5 5UIW
TM7 273 7.31x30 CB1 receptor 5XRA - -
TM7 274 7.32x31 CB1 receptor 5XRA apelin receptor 5VBL
TM7 275 7.33x32 CB1 receptor 5XRA κ receptor 6B73
TM7 276 7.34x33 CB1 receptor 5XRA - -
TM7 277 7.35x34 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 278 7.36x35 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM7 279 7.37x36 CB1 receptor 5XRA - -
TM7 280 7.38x37 CB1 receptor 5XRA - -
TM7 281 7.39x38 CB1 receptor 5XRA LPA6 receptor 5XSZ
TM7 282 7.40x39 CB1 receptor 5XRA FFA1 receptor 5TZY
TM7 283 7.41x40 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 284 7.42x41 CB1 receptor 5XRA - -
TM7 285 7.43x42 CB1 receptor 5XRA CCR5 5UIW
TM7 286 7.44x43 CB1 receptor 5XRA US28 4XT1
TM7 287 7.45x45 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 288 7.46x46 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 289 7.47x47 CB1 receptor 5XRA A2A receptor 5G53
TM7 290 7.48x48 CB1 receptor 5XRA A1 receptor 6D9H
TM7 291 7.49x49 CB1 receptor 5XRA LPA6 receptor 5XSZ
TM7 292 7.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 293 7.51x51 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM7 294 7.52x52 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 295 7.53x53 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 296 7.54x54 LPA1 receptor 4Z35 A2A receptor 5G53
TM7 297 7.55x55 LPA1 receptor 4Z35 A1 receptor 6D9H
TM7 298 7.56x56 LPA1 receptor 4Z35 LPA1 receptor 4Z35
H8 299 8.47x47 CB1 receptor 5XRA CB1 receptor 5XRA
H8 300 8.48x48 CB1 receptor 5XRA A1 receptor 6D9H
H8 301 8.49x49 CB1 receptor 5XRA LPA1 receptor 4Z35
H8 302 8.50x50 CB1 receptor 5XRA LPA1 receptor 4Z35
H8 303 8.51x51 CB1 receptor 5XRA CB1 receptor 5XRA
H8 304 8.52x52 CB1 receptor 5XRA H1 receptor 3RZE
H8 305 8.53x53 CB1 receptor 5XRA A2A receptor 5G53
H8 306 8.54x54 CB1 receptor 5XRA CB1 receptor 5XRA
H8 307 8.55x55 CB1 receptor 5XRA M2 receptor 4MQT
H8 308 8.56x56 CB1 receptor 5XRA β2-adrenoceptor 3SN6
H8 309 8.57x57 CB1 receptor 5XRA A2A receptor 5G53
H8 310 8.58x58 CB1 receptor 5XRA - -
H8 311 8.59x59 A2A receptor 4UHR β2-adrenoceptor 3SN6
C-term 312 - - - -
C-term 313 - - - -
C-term 314 - - - -
C-term 315 - - - -
C-term 316 - - - -