MC5 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive (Δ distance (Å): -1.38 docs)

VERSION

2018-07-10

MAIN TEMPLATE

LPA1 receptor (sequence similarity: 44%) PDB: 4Z35

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 79.2 8.7 12.2
Side-chains 22.2 51.4 26.4

Number of backbone templates: 7
Number of rotamer templates: 41

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4Z35
4PXZ
4UHR
4DJH
3V2Y
4N6H
5XRA
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 29 LPA1 receptor 4Z35 LPA1 receptor 4Z35
N-term 30 LPA1 receptor 4Z35 LPA1 receptor 4Z35
N-term 31 LPA1 receptor 4Z35 LPA1 receptor 4Z35
N-term 32 LPA1 receptor 4Z35 LPA1 receptor 4Z35
N-term 33 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM1 34 1.30x30 LPA1 receptor 4Z35 - -
TM1 35 1.31x31 LPA1 receptor 4Z35 - -
TM1 36 1.32x32 LPA1 receptor 4Z35 M4 receptor 5DSG
TM1 37 1.33x33 LPA1 receptor 4Z35 - -
TM1 38 1.34x34 LPA1 receptor 4Z35 κ receptor 4DJH
TM1 39 1.35x35 LPA1 receptor 4Z35 D4 receptor 5WIV
TM1 40 1.36x36 LPA1 receptor 4Z35 NOP receptor 5DHG
TM1 41 1.37x37 LPA1 receptor 4Z35 - -
TM1 42 1.38x38 LPA1 receptor 4Z35 S1P1 receptor 3V2Y
TM1 43 1.39x39 LPA1 receptor 4Z35 S1P1 receptor 3V2Y
TM1 44 1.40x40 LPA1 receptor 4Z35 A2A receptor 3VG9
TM1 45 1.41x41 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM1 46 1.42x42 LPA1 receptor 4Z35 CB1 receptor 5TGZ
TM1 47 1.43x43 LPA1 receptor 4Z35 CB1 receptor 5TGZ
TM1 48 1.44x44 LPA1 receptor 4Z35 A2A receptor 3VG9
TM1 49 1.45x45 LPA1 receptor 4Z35 P2Y1 receptor 4XNW
TM1 50 1.46x46 LPA1 receptor 4Z35 A1 receptor 5UEN
TM1 51 1.47x47 LPA1 receptor 4Z35 κ receptor 4DJH
TM1 52 1.48x48 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM1 53 1.49x49 LPA1 receptor 4Z35 S1P1 receptor 3V2Y
TM1 54 1.50x50 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM1 55 1.51x51 LPA1 receptor 4Z35 S1P1 receptor 3V2Y
TM1 56 1.52x52 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM1 57 1.53x53 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM1 58 1.54x54 LPA1 receptor 4Z35 5-HT2C receptor 6BQH
TM1 59 1.55x55 LPA1 receptor 4Z35 - -
TM1 60 1.56x56 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM1 61 1.57x57 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM1 62 1.58x58 LPA1 receptor 4Z35 δ receptor 4N6H
TM1 63 1.59x59 LPA1 receptor 4Z35 OX2 receptor 5WS3
TM1 64 1.60x60 LPA1 receptor 4Z35 LPA1 receptor 4Z35
ICL1 65 12.48x48 LPA1 receptor 4Z35 S1P1 receptor 3V2Y
ICL1 66 12.49x49 LPA1 receptor 4Z35 A2A receptor 3VG9
ICL1 67 12.50x50 LPA1 receptor 4Z35 A2A receptor 3VG9
ICL1 68 12.51x51 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM2 69 2.37x37 LPA1 receptor 4Z35 CXCR4 3ODU
TM2 70 2.38x38 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM2 71 2.39x39 LPA1 receptor 4Z35 S1P1 receptor 3V2Y
TM2 72 2.40x40 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM2 73 2.41x41 LPA1 receptor 4Z35 - -
TM2 74 2.42x42 LPA1 receptor 4Z35 S1P1 receptor 3V2Y
TM2 75 2.43x43 LPA1 receptor 4Z35 A2A receptor 3VG9
TM2 76 2.44x44 LPA1 receptor 4Z35 - -
TM2 77 2.45x45 LPA1 receptor 4Z35 A2A receptor 3VG9
TM2 78 2.46x46 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM2 79 2.47x47 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM2 80 2.48x48 LPA1 receptor 4Z35 CB1 receptor 5TGZ
TM2 81 2.49x49 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM2 82 2.50x50 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM2 83 2.51x51 LPA1 receptor 4Z35 5-HT2C receptor 6BQH
TM2 84 2.52x52 LPA1 receptor 4Z35 S1P1 receptor 3V2Y
TM2 85 2.53x53 LPA1 receptor 4Z35 A2A receptor 3VG9
TM2 86 2.54x54 LPA1 receptor 4Z35 CB1 receptor 5TGZ
TM2 87 2.55x55 LPA1 receptor 4Z35 - -
TM2 88 2.56x56 LPA1 receptor 4Z35 M3 receptor 4U15
TM2 89 2.57x57 LPA1 receptor 4Z35 - -
TM2 90 2.58x58 LPA1 receptor 4Z35 - -
TM2 91 2.59x59 LPA1 receptor 4Z35 D2 receptor 6CM4
TM2 92 2.60x60 LPA1 receptor 4Z35 NTS1 receptor 4BUO
TM2 93 2.61x61 LPA1 receptor 4Z35 M3 receptor 4U15
TM2 94 2.62x62 LPA1 receptor 4Z35 CB1 receptor 5TGZ
TM2 95 2.63x63 LPA1 receptor 4Z35 Rhodopsin 1GZM
ECL1 96 - - - -
ECL1 97 - - - -
ECL1 98 - - - -
ECL1 99 - - - -
ECL1 100 - - - -
ECL1 101 - - - -
ECL1 102 - - - -
ECL1 103 - - - -
ECL1 104 - - - -
ECL1 105 - - - -
ECL1 106 - - - -
ECL1 107 - - - -
TM3 108 3.18x18 P2Y12 receptor 4PXZ - -
TM3 109 3.19x19 P2Y12 receptor 4PXZ - -
TM3 110 3.20x20 P2Y12 receptor 4PXZ - -
TM3 111 3.21x21 LPA1 receptor 4Z35 - -
TM3 112 3.22x22 LPA1 receptor 4Z35 CB1 receptor 5TGZ
TM3 113 3.23x23 LPA1 receptor 4Z35 A2A receptor 3VG9
TM3 114 3.24x24 LPA1 receptor 4Z35 - -
TM3 115 3.25x25 LPA1 receptor 4Z35 - -
TM3 116 3.26x26 LPA1 receptor 4Z35 Rhodopsin 1GZM
TM3 117 3.27x27 LPA1 receptor 4Z35 5-HT2C receptor 6BQH
TM3 118 3.28x28 LPA1 receptor 4Z35 D2 receptor 6CM4
TM3 119 3.29x29 LPA1 receptor 4Z35 - -
TM3 120 3.30x30 LPA1 receptor 4Z35 κ receptor 4DJH
TM3 121 3.31x31 LPA1 receptor 4Z35 H1 receptor 3RZE
TM3 122 3.32x32 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM3 123 3.33x33 LPA1 receptor 4Z35 Y1 receptor 5ZBH
TM3 124 3.34x34 LPA1 receptor 4Z35 A1 receptor 5UEN
TM3 125 3.35x35 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM3 126 3.36x36 LPA1 receptor 4Z35 OX2 receptor 5WS3
TM3 127 3.37x37 LPA1 receptor 4Z35 - -
TM3 128 3.38x38 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM3 129 3.39x39 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM3 130 3.40x40 LPA1 receptor 4Z35 - -
TM3 131 3.41x41 LPA1 receptor 4Z35 US28 4XT1
TM3 132 3.42x42 LPA1 receptor 4Z35 S1P1 receptor 3V2Y
TM3 133 3.43x43 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM3 134 3.44x44 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM3 135 3.45x45 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM3 136 3.46x46 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM3 137 3.47x47 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM3 138 3.48x48 LPA1 receptor 4Z35 κ receptor 4DJH
TM3 139 3.49x49 LPA1 receptor 4Z35 A2A receptor 3VG9
TM3 140 3.50x50 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM3 141 3.51x51 LPA1 receptor 4Z35 S1P1 receptor 3V2Y
TM3 142 3.52x52 LPA1 receptor 4Z35 NOP receptor 5DHG
TM3 143 3.53x53 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM3 144 3.54x54 LPA1 receptor 4Z35 A2A receptor 3VG9
TM3 145 3.55x55 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM3 146 3.56x56 LPA1 receptor 4Z35 PAR1 3VW7
ICL2 147 34.50x50 - - - -
ICL2 148 34.51x51 A2A receptor 4UHR A2A receptor 4UHR
ICL2 149 34.52x52 A2A receptor 4UHR A2A receptor 4UHR
ICL2 150 34.53x53 A2A receptor 4UHR A2A receptor 4UHR
ICL2 151 34.54x54 A2A receptor 4UHR CCR9 5LWE
ICL2 152 34.55x55 A2A receptor 4UHR D3 receptor 3PBL
ICL2 153 34.56x56 A2A receptor 4UHR CB1 receptor 5TGZ
ICL2 154 34.57x57 - - - -
TM4 155 4.38x38 LPA1 receptor 4Z35 κ receptor 4DJH
TM4 156 4.39x39 LPA1 receptor 4Z35 OX2 receptor 5WS3
TM4 157 4.40x40 LPA1 receptor 4Z35 LPA1 receptor 4Z36
TM4 158 4.41x41 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM4 159 4.42x42 LPA1 receptor 4Z35 CCR9 5LWE
TM4 160 4.43x43 LPA1 receptor 4Z35 M3 receptor 4U15
TM4 161 4.44x44 LPA1 receptor 4Z35 NOP receptor 5DHG
TM4 162 4.45x45 LPA1 receptor 4Z35 A2A receptor 3VG9
TM4 163 4.46x46 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM4 164 4.47x47 LPA1 receptor 4Z35 A2A receptor 3VG9
TM4 165 4.48x48 LPA1 receptor 4Z35 H1 receptor 3RZE
TM4 166 4.49x49 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM4 167 4.50x50 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM4 168 4.51x51 LPA1 receptor 4Z35 NOP receptor 5DHG
TM4 169 4.52x52 LPA1 receptor 4Z35 5-HT1B receptor 4IAQ
TM4 170 4.53x53 LPA1 receptor 4Z35 - -
TM4 171 4.54x54 LPA1 receptor 4Z35 - -
TM4 172 4.55x55 LPA1 receptor 4Z35 δ receptor 4N6H
TM4 173 4.56x56 LPA1 receptor 4Z35 Rhodopsin 1GZM
TM4 174 4.57x57 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM4 175 4.58x58 LPA1 receptor 4Z35 κ receptor 4DJH
TM4 176 4.59x59 LPA1 receptor 4Z35 5-HT2C receptor 6BQH
TM4 177 4.60x60 LPA1 receptor 4Z35 PAF receptor 5ZKP
TM4 178 4.61x61 LPA1 receptor 4Z35 S1P1 receptor 3V2Y
TM4 179 4.62x62 LPA1 receptor 4Z35 A2A receptor 3VG9
TM4 180 4.63x63 LPA1 receptor 4Z35 P2Y1 receptor 4XNW
ECL2 181 - - - -
ECL2 182 - - - -
ECL2 183 - - - -
ECL2 184 - - - -
ECL2 185 - - - -
ECL2 186 - - - -
ECL2 187 - - - -
ECL2 188 - - - -
ECL2 189 - - - -
TM5 190 5.33x33 κ receptor 4DJH P2Y1 receptor 4XNW
TM5 191 5.34x34 κ receptor 4DJH OX2 receptor 5WS3
TM5 192 5.35x35 κ receptor 4DJH P2Y1 receptor 4XNW
TM5 193 5.36x36 LPA1 receptor 4Z35 - -
TM5 194 5.37x37 LPA1 receptor 4Z35 P2Y1 receptor 4XNW
TM5 195 5.38x38 LPA1 receptor 4Z35 κ receptor 4DJH
TM5 196 5.39x39 LPA1 receptor 4Z35 FFA1 receptor 5TZY
TM5 197 5.40x40 LPA1 receptor 4Z35 A2A receptor 3VG9
TM5 198 5.41x41 LPA1 receptor 4Z35 S1P1 receptor 3V2Y
TM5 199 5.42x42 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM5 200 5.43x43 LPA1 receptor 4Z35 Y1 receptor 5ZBH
TM5 201 5.44x44 LPA1 receptor 4Z35 Y1 receptor 5ZBH
TM5 202 5.45x45 LPA1 receptor 4Z35 D4 receptor 5WIV
TM5 203 5.46x46 LPA1 receptor 4Z35 PAF receptor 5ZKP
TM5 204 5.47x47 LPA1 receptor 4Z35 CXCR4 3ODU
TM5 205 5.48x48 LPA1 receptor 4Z35 D2 receptor 6CM4
TM5 206 5.49x49 LPA1 receptor 4Z35 κ receptor 4DJH
TM5 207 5.50x50 LPA1 receptor 4Z35 - -
TM5 208 5.51x51 LPA1 receptor 4Z35 NTS1 receptor 4BUO
TM5 209 5.52x52 LPA1 receptor 4Z35 PAR2 5NDD
TM5 210 5.53x53 LPA1 receptor 4Z35 A2A receptor 3VG9
TM5 211 5.54x54 LPA1 receptor 4Z35 C5a1 receptor 5O9H
TM5 212 5.55x55 LPA1 receptor 4Z35 OX1 receptor 4ZJ8
TM5 213 5.56x56 LPA1 receptor 4Z35 - -
TM5 214 5.57x57 LPA1 receptor 4Z35 5-HT2C receptor 6BQH
TM5 215 5.58x58 LPA1 receptor 4Z35 - -
TM5 216 5.59x59 LPA1 receptor 4Z35 PAR1 3VW7
TM5 217 5.60x60 LPA1 receptor 4Z35 H1 receptor 3RZE
TM5 218 5.61x61 LPA1 receptor 4Z35 - -
TM5 219 5.62x62 LPA1 receptor 4Z35 κ receptor 4DJH
TM5 220 5.63x63 LPA1 receptor 4Z35 A2A receptor 5IU4
TM5 221 5.64x64 LPA1 receptor 4Z35 A2A receptor 3VG9
TM5 222 5.65x65 LPA1 receptor 4Z35 κ receptor 4DJH
TM5 223 5.66x66 S1P1 receptor 3V2Y - -
TM5 224 5.67x67 S1P1 receptor 3V2Y - -
ICL3 225 - - - -
ICL3 226 - - - -
ICL3 227 - - - -
ICL3 228 - - - -
ICL3 229 - - - -
TM6 230 6.27x27 LPA1 receptor 4Z35 Rhodopsin 1GZM
TM6 231 6.28x28 LPA1 receptor 4Z35 CB1 receptor 5TGZ
TM6 232 6.29x29 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM6 233 6.30x30 LPA1 receptor 4Z35 C5a1 receptor 6C1R
TM6 234 6.31x31 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM6 235 6.32x32 LPA1 receptor 4Z35 AT2 receptor 5UNG
TM6 236 6.33x33 LPA1 receptor 4Z35 NTS1 receptor 4BUO
TM6 237 6.34x34 LPA1 receptor 4Z35 A2A receptor 3VG9
TM6 238 6.35x35 LPA1 receptor 4Z35 - -
TM6 239 6.36x36 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM6 240 6.37x37 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM6 241 6.38x38 LPA1 receptor 4Z35 - -
TM6 242 6.39x39 LPA1 receptor 4Z35 - -
TM6 243 6.40x40 LPA1 receptor 4Z35 CXCR4 3ODU
TM6 244 6.41x41 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM6 245 6.42x42 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM6 246 6.43x43 LPA1 receptor 4Z35 S1P1 receptor 3V2Y
TM6 247 6.44x44 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM6 248 6.45x45 LPA1 receptor 4Z35 β2-adrenoceptor 5JQH
TM6 249 6.46x46 LPA1 receptor 4Z35 κ receptor 4DJH
TM6 250 6.47x47 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM6 251 6.48x48 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM6 252 6.49x49 LPA1 receptor 4Z35 S1P1 receptor 3V2Y
TM6 253 6.50x50 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM6 254 6.51x51 LPA1 receptor 4Z35 D2 receptor 6CM4
TM6 255 6.52x52 LPA1 receptor 4Z35 S1P1 receptor 3V2Y
TM6 256 6.53x53 LPA1 receptor 4Z35 D3 receptor 3PBL
TM6 257 6.54x54 LPA1 receptor 4Z35 - -
TM6 258 6.55x55 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM6 259 6.56x56 LPA1 receptor 4Z35 Y1 receptor 5ZBH
TM6 260 6.57x57 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM6 261 6.58x58 LPA1 receptor 4Z35 C5a1 receptor 5O9H
TM6 262 6.59x59 LPA1 receptor 4Z35 A1 receptor 5UEN
TM6 263 6.60x60 LPA1 receptor 4Z35 BLT1 receptor 5X33
TM6 264 6.61x61 LPA1 receptor 4Z35 LPA1 receptor 4Z35
ECL3 265 - - - -
ECL3 266 δ receptor 4N6H - -
ECL3 267 δ receptor 4N6H - -
ECL3 268 δ receptor 4N6H - -
ECL3 269 - - - -
TM7 270 7.28x27 CB1 receptor 5XRA - -
TM7 271 7.29x28 CB1 receptor 5XRA CCR2 5T1A
TM7 272 7.30x29 CB1 receptor 5XRA CCR5 5UIW
TM7 273 7.31x30 CB1 receptor 5XRA - -
TM7 274 7.32x31 CB1 receptor 5XRA apelin receptor 5VBL
TM7 275 7.33x32 CB1 receptor 5XRA κ receptor 4DJH
TM7 276 7.34x33 CB1 receptor 5XRA - -
TM7 277 7.35x34 LPA1 receptor 4Z35 CB1 receptor 5TGZ
TM7 278 7.36x35 LPA1 receptor 4Z35 5-HT2C receptor 6BQH
TM7 279 7.37x36 LPA1 receptor 4Z35 - -
TM7 280 7.38x37 LPA1 receptor 4Z35 - -
TM7 281 7.39x38 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM7 282 7.40x39 LPA1 receptor 4Z35 FFA1 receptor 5TZY
TM7 283 7.41x40 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM7 284 7.42x41 LPA1 receptor 4Z35 - -
TM7 285 7.43x42 LPA1 receptor 4Z35 CCR5 5UIW
TM7 286 7.44x43 LPA1 receptor 4Z35 US28 4XT1
TM7 287 7.45x45 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM7 288 7.46x46 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM7 289 7.47x47 LPA1 receptor 4Z35 A2A receptor 3VG9
TM7 290 7.48x48 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM7 291 7.49x49 LPA1 receptor 4Z35 PAR1 3VW7
TM7 292 7.50x50 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM7 293 7.51x51 LPA1 receptor 4Z35 H1 receptor 3RZE
TM7 294 7.52x52 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM7 295 7.53x53 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM7 296 7.54x54 LPA1 receptor 4Z35 A2A receptor 3VG9
TM7 297 7.55x55 LPA1 receptor 4Z35 κ receptor 4DJH
TM7 298 7.56x56 LPA1 receptor 4Z35 LPA1 receptor 4Z35
H8 299 8.47x47 LPA1 receptor 4Z35 CB1 receptor 5TGZ
H8 300 8.48x48 LPA1 receptor 4Z35 A1 receptor 5UEN
H8 301 8.49x49 LPA1 receptor 4Z35 LPA1 receptor 4Z35
H8 302 8.50x50 LPA1 receptor 4Z35 LPA1 receptor 4Z35
H8 303 8.51x51 LPA1 receptor 4Z35 A2A receptor 3VG9
H8 304 8.52x52 LPA1 receptor 4Z35 H1 receptor 3RZE
H8 305 8.53x53 LPA1 receptor 4Z35 LPA1 receptor 4Z35
H8 306 8.54x54 LPA1 receptor 4Z35 LPA1 receptor 4Z35
H8 307 8.55x55 LPA1 receptor 4Z35 H1 receptor 3RZE
H8 308 8.56x56 LPA1 receptor 4Z35 β2-adrenoceptor 2RH1
H8 309 8.57x57 LPA1 receptor 4Z35 LPA1 receptor 4Z36
H8 310 8.58x58 LPA1 receptor 4Z35 A2A receptor 3VG9
H8 311 8.59x59 A2A receptor 4UHR β2-adrenoceptor 5JQH
C-term 312 - - - -
C-term 313 - - - -
C-term 314 - - - -
C-term 315 - - - -
C-term 316 - - - -