MRGPRG homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate (Δ distance (Å): 5.15 docs)

VERSION

2018-07-10

MAIN TEMPLATE

P2Y1 receptor (sequence similarity: 30%) PDB: 4XNW

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 77.0 10.8 12.3
Side-chains 14.9 55.0 30.1

Number of backbone templates: 5
Number of rotamer templates: 35

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4XNW
5O9H
3VW7
5TZY
5VBL
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 5 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
N-term 6 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
N-term 7 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
N-term 8 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
N-term 9 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM1 10 1.30x30 P2Y1 receptor 4XNW ETB receptor 5X93
TM1 11 1.31x31 P2Y1 receptor 4XNW ETB receptor 5X93
TM1 12 1.32x32 P2Y1 receptor 4XNW C5a1 receptor 5O9H
TM1 13 1.33x33 P2Y1 receptor 4XNW A2A receptor 4UHR
TM1 14 1.34x34 P2Y1 receptor 4XNW A2A receptor 4UHR
TM1 15 1.35x35 P2Y1 receptor 4XNW PAR1 3VW7
TM1 16 1.36x36 P2Y1 receptor 4XNW FFA1 receptor 5TZY
TM1 17 1.37x37 P2Y1 receptor 4XNW - -
TM1 18 1.38x38 P2Y1 receptor 4XNW FFA1 receptor 5TZY
TM1 19 1.39x39 P2Y1 receptor 4XNW M1 receptor 5CXV
TM1 20 1.40x40 P2Y1 receptor 4XNW NTS1 receptor 4XES
TM1 21 1.41x41 P2Y1 receptor 4XNW PAR2 5NDD
TM1 22 1.42x42 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM1 23 1.43x43 P2Y1 receptor 4XNW CB1 receptor 5XRA
TM1 24 1.44x44 P2Y1 receptor 4XNW 5-HT1B receptor 4IAQ
TM1 25 1.45x45 P2Y1 receptor 4XNW NOP receptor 5DHG
TM1 26 1.46x46 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM1 27 1.47x47 P2Y1 receptor 4XNW - -
TM1 28 1.48x48 P2Y1 receptor 4XNW NTS1 receptor 4XES
TM1 29 1.49x49 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM1 30 1.50x50 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM1 31 1.51x51 P2Y1 receptor 4XNW PAR2 5NDD
TM1 32 1.52x52 P2Y1 receptor 4XNW μ receptor 6DDE
TM1 33 1.53x53 P2Y1 receptor 4XNW μ receptor 6DDE
TM1 34 1.54x54 P2Y1 receptor 4XNW PAR2 5NDD
TM1 35 1.55x55 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM1 36 1.56x56 P2Y1 receptor 4XNW - -
TM1 37 1.57x57 P2Y1 receptor 4XNW NTS1 receptor 4XES
TM1 38 1.58x58 P2Y1 receptor 4XNW CXCR4 3ODU
TM1 39 1.59x59 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM1 40 1.60x60 P2Y1 receptor 4XNW PAR2 5NDD
ICL1 41 - - - -
ICL1 42 C5a1 receptor 5O9H C5a1 receptor 5O9H
ICL1 43 - - - -
TM2 44 2.37x37 P2Y1 receptor 4XNW - -
TM2 45 2.38x38 P2Y1 receptor 4XNW PAR1 3VW7
TM2 46 2.39x39 P2Y1 receptor 4XNW P2Y12 receptor 4NTJ
TM2 47 2.40x40 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM2 48 2.41x41 P2Y1 receptor 4XNW PAR2 5NDD
TM2 49 2.42x42 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM2 50 2.43x43 P2Y1 receptor 4XNW NTS1 receptor 4XES
TM2 51 2.44x44 P2Y1 receptor 4XNW PAR1 3VW7
TM2 52 2.45x45 P2Y1 receptor 4XNW PAR1 3VW7
TM2 53 2.46x46 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM2 54 2.47x47 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM2 55 2.48x48 P2Y1 receptor 4XNW A2A receptor 4UHR
TM2 56 2.49x49 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM2 57 2.50x50 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM2 58 2.51x51 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM2 59 2.52x52 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM2 60 2.53x53 P2Y1 receptor 4XNW PAR1 3VW7
TM2 61 2.54x54 P2Y1 receptor 4XNW NTS1 receptor 4XES
TM2 62 2.55x55 P2Y1 receptor 4XNW PAR1 3VW7
TM2 63 2.56x56 P2Y1 receptor 4XNW OX1 receptor 4ZJ8
TM2 64 2.57x57 P2Y1 receptor 4XNW - -
TM2 65 2.58x58 P2Y1 receptor 4XNW CB1 receptor 5XRA
TM2 66 2.59x59 P2Y1 receptor 4XNW - -
TM2 67 2.60x60 P2Y1 receptor 4XNW BLT1 receptor 5X33
TM2 68 2.61x61 P2Y1 receptor 4XNW μ receptor 5C1M
TM2 69 2.62x62 P2Y1 receptor 4XNW μ receptor 6DDE
TM2 70 2.63x63 P2Y1 receptor 4XNW CCR9 5LWE
ECL1 71 - - - -
ECL1 72 - - - -
ECL1 73 - - - -
ECL1 74 - - - -
ECL1 75 - - - -
ECL1 76 - - - -
ECL1 77 - - - -
ECL1 78 - - - -
TM3 79 3.26x26 P2Y1 receptor 4XNW US28 4XT1
TM3 80 3.27x27 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM3 81 3.28x28 P2Y1 receptor 4XNW NTS1 receptor 4XES
TM3 82 3.29x29 P2Y1 receptor 4XNW - -
TM3 83 3.30x30 P2Y1 receptor 4XNW FFA1 receptor 5TZY
TM3 84 3.31x31 P2Y1 receptor 4XNW NTS1 receptor 4XES
TM3 85 3.32x32 P2Y1 receptor 4XNW - -
TM3 86 3.33x33 P2Y1 receptor 4XNW FFA1 receptor 5TZY
TM3 87 3.34x34 P2Y1 receptor 4XNW 5-HT2B receptor 4IB4
TM3 88 3.35x35 P2Y1 receptor 4XNW - -
TM3 89 3.36x36 P2Y1 receptor 4XNW CCR9 5LWE
TM3 90 3.37x37 P2Y1 receptor 4XNW A2A receptor 4UHR
TM3 91 3.38x38 P2Y1 receptor 4XNW OX1 receptor 4ZJ8
TM3 92 3.39x39 P2Y1 receptor 4XNW FFA1 receptor 5TZY
TM3 93 3.40x40 P2Y1 receptor 4XNW US28 4XT1
TM3 94 3.41x41 P2Y1 receptor 4XNW 5-HT1B receptor 4IAQ
TM3 95 3.42x42 P2Y1 receptor 4XNW PAR1 3VW7
TM3 96 3.43x43 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM3 97 3.44x44 P2Y1 receptor 4XNW FFA1 receptor 5TZY
TM3 98 3.45x45 P2Y1 receptor 4XNW FFA1 receptor 5TZY
TM3 99 3.46x46 P2Y1 receptor 4XNW - -
TM3 100 3.47x47 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM3 101 3.48x48 P2Y1 receptor 4XNW PAR2 5NDD
TM3 102 3.49x49 P2Y1 receptor 4XNW NTS1 receptor 4XEE
TM3 103 3.50x50 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM3 104 3.51x51 P2Y1 receptor 4XNW - -
TM3 105 3.52x52 P2Y1 receptor 4XNW PAR1 3VW7
TM3 106 3.53x53 P2Y1 receptor 4XNW AT2 receptor 5UNG
TM3 107 3.54x54 P2Y1 receptor 4XNW - -
TM3 108 3.55x55 P2Y1 receptor 4XNW - -
TM3 109 3.56x56 P2Y1 receptor 4XNW FFA1 receptor 5TZY
ICL2 110 34.50x50 - - - -
ICL2 111 34.51x51 C5a1 receptor 5O9H C5a1 receptor 5O9H
ICL2 112 34.52x52 C5a1 receptor 5O9H - -
ICL2 113 34.53x53 C5a1 receptor 5O9H FFA1 receptor 5TZY
ICL2 114 34.54x54 C5a1 receptor 5O9H C5a1 receptor 5O9H
ICL2 115 34.55x55 C5a1 receptor 5O9H P2Y1 receptor 4XNW
ICL2 116 34.56x56 C5a1 receptor 5O9H - -
ICL2 117 34.57x57 - - - -
TM4 118 4.38x38 P2Y1 receptor 4XNW US28 4XT1
TM4 119 4.39x39 P2Y1 receptor 4XNW NTS1 receptor 4XES
TM4 120 4.40x40 P2Y1 receptor 4XNW - -
TM4 121 4.41x41 P2Y1 receptor 4XNW CXCR4 3ODU
TM4 122 4.42x42 P2Y1 receptor 4XNW FFA1 receptor 5TZY
TM4 123 4.43x43 P2Y1 receptor 4XNW 5-HT1B receptor 4IAQ
TM4 124 4.44x44 P2Y1 receptor 4XNW 5-HT1B receptor 4IAQ
TM4 125 4.45x45 P2Y1 receptor 4XNW PAF receptor 5ZKQ
TM4 126 4.46x46 P2Y1 receptor 4XNW PAR1 3VW7
TM4 127 4.47x47 P2Y1 receptor 4XNW FFA1 receptor 5TZY
TM4 128 4.48x48 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM4 129 4.49x49 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM4 130 4.50x50 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM4 131 4.51x51 P2Y1 receptor 4XNW CB1 receptor 5XRA
TM4 132 4.52x52 P2Y1 receptor 4XNW CXCR4 3ODU
TM4 133 4.53x53 P2Y1 receptor 4XNW - -
TM4 134 4.54x54 P2Y1 receptor 4XNW PAR2 5NDD
TM4 135 4.55x55 P2Y1 receptor 4XNW - -
TM4 136 4.56x56 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM4 137 4.57x57 P2Y1 receptor 4XNW PAR1 3VW7
TM4 138 4.58x58 P2Y1 receptor 4XNW - -
TM4 139 4.59x59 P2Y1 receptor 4XNW FFA1 receptor 5TZY
TM4 140 4.60x60 P2Y1 receptor 4XNW PAR1 3VW7
TM4 141 4.61x61 P2Y1 receptor 4XNW AT1 receptor 4ZUD
TM4 142 4.62x62 P2Y1 receptor 4XNW - -
TM4 143 4.63x63 P2Y1 receptor 4XNW OX1 receptor 4ZJ8
TM4 144 4.64x64 P2Y1 receptor 4XNW - -
ECL2 145 - - - -
ECL2 146 - - - -
ECL2 147 - - - -
ECL2 148 - - - -
ECL2 149 - - - -
ECL2 150 - - - -
ECL2 151 - - - -
ECL2 152 - - - -
ECL2 153 - - - -
ECL2 154 - - - -
ECL2 155 - - - -
TM5 156 5.34x34 P2Y1 receptor 4XNW - -
TM5 157 5.35x35 P2Y1 receptor 4XNW PAF receptor 5ZKQ
TM5 158 5.36x36 P2Y1 receptor 4XNW Y1 receptor 5ZBH
TM5 159 5.37x37 P2Y1 receptor 4XNW PAR1 3VW7
TM5 160 5.38x38 P2Y1 receptor 4XNW S1P1 receptor 3V2Y
TM5 161 5.39x39 P2Y1 receptor 4XNW NTS1 receptor 4XES
TM5 162 5.40x40 P2Y1 receptor 4XNW C5a1 receptor 5O9H
TM5 163 5.41x41 P2Y1 receptor 4XNW OX1 receptor 4ZJ8
TM5 164 5.42x42 P2Y1 receptor 4XNW NTS1 receptor 4XES
TM5 165 5.43x43 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM5 166 5.44x44 P2Y1 receptor 4XNW - -
TM5 167 5.45x45 P2Y1 receptor 4XNW NTS1 receptor 4XES
TM5 168 5.46x46 PAR1 3VW7 FFA1 receptor 5TZY
TM5 169 5.47x47 PAR1 3VW7 A2A receptor 4UHR
TM5 170 5.48x48 P2Y1 receptor 4XNW PAR2 5NDD
TM5 171 5.49x49 P2Y1 receptor 4XNW OX1 receptor 4ZJ8
TM5 172 5.50x50 P2Y1 receptor 4XNW - -
TM5 173 5.51x51 P2Y1 receptor 4XNW μ receptor 6DDE
TM5 174 5.52x52 P2Y1 receptor 4XNW FFA1 receptor 5TZY
TM5 175 5.53x53 P2Y1 receptor 4XNW - -
TM5 176 5.54x54 P2Y1 receptor 4XNW PAR2 5NDD
TM5 177 5.55x55 P2Y1 receptor 4XNW PAR2 5NDD
TM5 178 5.56x56 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM5 179 5.57x57 P2Y1 receptor 4XNW A2A receptor 4UHR
TM5 180 5.58x58 P2Y1 receptor 4XNW - -
TM5 181 5.59x59 P2Y1 receptor 4XNW A2A receptor 4UHR
TM5 182 5.60x60 P2Y1 receptor 4XNW C5a1 receptor 5O9H
TM5 183 5.61x61 P2Y1 receptor 4XNW LPA6 receptor 5XSZ
TM5 184 5.62x62 P2Y1 receptor 4XNW AT1 receptor 4YAY
TM5 185 5.63x63 P2Y1 receptor 4XNW 5-HT1B receptor 4IAQ
TM5 186 5.64x64 P2Y1 receptor 4XNW PAF receptor 5ZKQ
TM5 187 5.65x65 P2Y1 receptor 4XNW - -
TM5 188 5.66x66 P2Y1 receptor 4XNW - -
TM5 189 5.67x67 P2Y1 receptor 4XNW μ receptor 6DDE
ICL3 190 - - - -
ICL3 191 - - - -
ICL3 192 - - - -
TM6 193 6.30x30 P2Y1 receptor 4XNW FFA1 receptor 5TZY
TM6 194 6.31x31 P2Y1 receptor 4XNW - -
TM6 195 6.32x32 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM6 196 6.33x33 P2Y1 receptor 4XNW FFA1 receptor 5KW2
TM6 197 6.34x34 P2Y1 receptor 4XNW - -
TM6 198 6.35x35 P2Y1 receptor 4XNW - -
TM6 199 6.36x36 P2Y1 receptor 4XNW AT1 receptor 4ZUD
TM6 200 6.37x37 P2Y1 receptor 4XNW μ receptor 6DDE
TM6 201 6.38x38 P2Y1 receptor 4XNW μ receptor 6DDE
TM6 202 6.39x39 P2Y1 receptor 4XNW FFA1 receptor 5TZY
TM6 203 6.40x40 P2Y1 receptor 4XNW PAR1 3VW7
TM6 204 6.41x41 P2Y1 receptor 4XNW FFA1 receptor 5KW2
TM6 205 6.42x42 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM6 206 6.43x43 P2Y1 receptor 4XNW FFA1 receptor 5TZY
TM6 207 6.44x44 P2Y1 receptor 4XNW CB1 receptor 5XRA
TM6 208 6.45x45 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM6 209 6.46x46 C5a1 receptor 5O9H P2Y12 receptor 4NTJ
TM6 210 6.47x47 C5a1 receptor 5O9H PAR1 3VW7
TM6 211 6.48x48 P2Y1 receptor 4XNW FFA1 receptor 5KW2
TM6 212 6.49x49 P2Y1 receptor 4XNW NTS1 receptor 4XES
TM6 213 6.50x50 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM6 214 6.51x51 P2Y1 receptor 4XNW PAR2 5NDD
TM6 215 6.52x52 P2Y1 receptor 4XNW - -
TM6 216 6.53x53 P2Y1 receptor 4XNW P2Y12 receptor 4NTJ
TM6 217 6.54x54 P2Y1 receptor 4XNW μ receptor 6DDE
TM6 218 6.55x55 P2Y1 receptor 4XNW - -
TM6 219 6.56x56 P2Y1 receptor 4XNW CXCR4 3ODU
TM6 220 6.57x57 P2Y1 receptor 4XNW AT1 receptor 4ZUD
TM6 221 6.58x58 P2Y1 receptor 4XNW CCR9 5LWE
TM6 222 6.59x59 P2Y1 receptor 4XNW 5-HT1B receptor 4IAQ
TM6 223 6.60x60 P2Y1 receptor 4XNW FFA1 receptor 5TZY
TM6 224 6.61x61 P2Y1 receptor 4XNW PAR2 5NDD
ECL3 225 - - - -
ECL3 226 FFA1 receptor 5TZY - -
ECL3 227 FFA1 receptor 5TZY FFA1 receptor 5TZY
ECL3 228 - - - -
TM7 229 7.32x31 P2Y1 receptor 4XNW D2 receptor 6CM4
TM7 230 7.33x32 P2Y1 receptor 4XNW μ receptor 6DDE
TM7 231 7.34x33 P2Y1 receptor 4XNW NTS1 receptor 4XES
TM7 232 7.35x34 P2Y1 receptor 4XNW FFA1 receptor 5KW2
TM7 233 7.36x35 P2Y1 receptor 4XNW AT1 receptor 4ZUD
TM7 234 7.37x36 P2Y1 receptor 4XNW PAR1 3VW7
TM7 235 7.38x37 P2Y1 receptor 4XNW PAR2 5NDD
TM7 236 7.39x38 P2Y1 receptor 4XNW 5-HT1B receptor 4IAQ
TM7 237 7.40x39 P2Y1 receptor 4XNW AT2 receptor 5UNG
TM7 238 7.41x40 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM7 239 7.42x41 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM7 240 7.43x42 P2Y1 receptor 4XNW - -
TM7 241 7.44x43 P2Y1 receptor 4XNW 5-HT2B receptor 4IB4
TM7 242 7.45x45 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM7 243 7.46x46 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM7 244 7.47x47 P2Y1 receptor 4XNW κ receptor 4DJH
TM7 245 7.48x48 P2Y1 receptor 4XNW - -
TM7 246 7.49x49 P2Y1 receptor 4XNW - -
TM7 247 7.50x50 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM7 248 7.51x51 P2Y1 receptor 4XNW PAR1 3VW7
TM7 249 7.52x52 P2Y1 receptor 4XNW PAR1 3VW7
TM7 250 7.53x53 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM7 251 7.54x54 P2Y1 receptor 4XNW LPA1 receptor 4Z35
TM7 252 7.55x55 P2Y1 receptor 4XNW - -
TM7 253 7.56x56 C5a1 receptor 5O9H PAF receptor 5ZKQ
H8 254 8.47x47 apelin receptor 5VBL AT2 receptor 5UNG
H8 255 8.48x48 apelin receptor 5VBL A2A receptor 4UHR
H8 256 8.49x49 apelin receptor 5VBL Rhodopsin 5DYS
H8 257 8.50x50 apelin receptor 5VBL - -
H8 258 8.51x51 apelin receptor 5VBL - -
H8 259 8.52x52 apelin receptor 5VBL D3 receptor 3PBL
H8 260 8.53x53 apelin receptor 5VBL - -
H8 261 8.54x54 apelin receptor 5VBL - -
H8 262 8.55x55 apelin receptor 5VBL - -
H8 263 8.56x56 apelin receptor 5VBL M1 receptor 5CXV
H8 264 8.57x57 apelin receptor 5VBL - -
H8 265 8.58x58 apelin receptor 5VBL - -
H8 266 8.59x59 apelin receptor 5VBL - -
H8 267 8.60x60 apelin receptor 5VBL - -
H8 268 8.61x61 apelin receptor 5VBL - -
C-term 269 - - - -
C-term 270 - - - -
C-term 271 - - - -
C-term 272 - - - -
C-term 273 - - - -