MRGPRX1 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive (Δ distance (Å): -1.44 docs)

VERSION

2018-07-10

MAIN TEMPLATE

C5a1 receptor (sequence similarity: 42%) PDB: 5O9H

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 83.3 8.3 8.3
Side-chains 22.5 51.1 26.4

Number of backbone templates: 7
Number of rotamer templates: 43

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5O9H
4DJH
3VW7
4YAY
5C1M
5NDD
5VBL
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 20 - - - -
N-term 21 - - - -
N-term 22 C5a1 receptor 5O9H C5a1 receptor 5O9H
N-term 23 C5a1 receptor 5O9H C5a1 receptor 5O9H
N-term 24 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 25 1.30x30 C5a1 receptor 5O9H - -
TM1 26 1.31x31 C5a1 receptor 5O9H CB1 receptor 5U09
TM1 27 1.32x32 C5a1 receptor 5O9H PAR2 5NDD
TM1 28 1.33x33 C5a1 receptor 5O9H BLT1 receptor 5X33
TM1 29 1.34x34 C5a1 receptor 5O9H - -
TM1 30 1.35x35 C5a1 receptor 5O9H CXCR4 3ODU
TM1 31 1.36x36 C5a1 receptor 5O9H κ receptor 4DJH
TM1 32 1.37x37 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 33 1.38x38 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM1 34 1.39x39 C5a1 receptor 5O9H M4 receptor 5DSG
TM1 35 1.40x40 C5a1 receptor 5O9H ETB receptor 5X93
TM1 36 1.41x41 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM1 37 1.42x42 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 38 1.43x43 C5a1 receptor 5O9H M2 receptor 3UON
TM1 39 1.44x44 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 40 1.45x45 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 41 1.46x46 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 42 1.47x47 C5a1 receptor 5O9H κ receptor 4DJH
TM1 43 1.48x48 C5a1 receptor 5O9H apelin receptor 5VBL
TM1 44 1.49x49 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 45 1.50x50 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 46 1.51x51 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 47 1.52x52 C5a1 receptor 5O9H NTS1 receptor 4BUO
TM1 48 1.53x53 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 49 1.54x54 C5a1 receptor 5O9H apelin receptor 5VBL
TM1 50 1.55x55 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 51 1.56x56 C5a1 receptor 5O9H AT2 receptor 5UNG
TM1 52 1.57x57 C5a1 receptor 5O9H NTS1 receptor 4BUO
TM1 53 1.58x58 C5a1 receptor 5O9H CXCR4 3ODU
TM1 54 1.59x59 C5a1 receptor 5O9H AT2 receptor 5UNG
TM1 55 1.60x60 C5a1 receptor 5O9H PAR2 5NDD
ICL1 56 C5a1 receptor 5O9H - -
ICL1 57 C5a1 receptor 5O9H - -
ICL1 58 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM2 59 2.37x37 C5a1 receptor 5O9H 5-HT2C receptor 6BQH
TM2 60 2.38x38 C5a1 receptor 5O9H κ receptor 4DJH
TM2 61 2.39x39 C5a1 receptor 5O9H P2Y12 receptor 4NTJ
TM2 62 2.40x40 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM2 63 2.41x41 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM2 64 2.42x42 C5a1 receptor 5O9H κ receptor 4DJH
TM2 65 2.43x43 C5a1 receptor 5O9H κ receptor 4DJH
TM2 66 2.44x44 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM2 67 2.45x45 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM2 68 2.46x46 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM2 69 2.47x47 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM2 70 2.48x48 C5a1 receptor 5O9H A2A receptor 3VG9
TM2 71 2.49x49 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM2 72 2.50x50 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM2 73 2.51x51 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM2 74 2.52x52 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM2 75 2.53x53 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM2 76 2.54x54 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM2 77 2.55x55 C5a1 receptor 5O9H δ receptor 4N6H
TM2 78 2.56x56 C5a1 receptor 5O9H Rhodopsin 1GZM
TM2 79 2.57x57 C5a1 receptor 5O9H - -
TM2 80 2.58x58 C5a1 receptor 5O9H - -
TM2 81 2.59x59 C5a1 receptor 5O9H C5a1 receptor 6C1R
TM2 82 2.60x60 C5a1 receptor 5O9H M2 receptor 3UON
TM2 83 2.61x61 C5a1 receptor 5O9H κ receptor 4DJH
TM2 84 2.62x62 C5a1 receptor 5O9H H1 receptor 3RZE
TM2 85 2.63x63 C5a1 receptor 5O9H D2 receptor 6CM4
TM2 86 2.64x64 C5a1 receptor 5O9H A2A receptor 3VG9
TM2 87 2.65x65 C5a1 receptor 5O9H P2Y1 receptor 4XNW
TM2 88 2.66x66 C5a1 receptor 5O9H M2 receptor 3UON
ECL1 89 C5a1 receptor 5O9H - -
ECL1 90 C5a1 receptor 5O9H C5a1 receptor 5O9H
ECL1 91 C5a1 receptor 5O9H C5a1 receptor 5O9H
ECL1 92 C5a1 receptor 5O9H C5a1 receptor 5O9H
ECL1 93 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM3 94 3.24x24 C5a1 receptor 5O9H - -
TM3 95 3.25x25 C5a1 receptor 5O9H - -
TM3 96 3.26x26 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM3 97 3.27x27 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM3 98 3.28x28 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM3 99 3.29x29 C5a1 receptor 5O9H NTS1 receptor 4BUO
TM3 100 3.30x30 C5a1 receptor 5O9H - -
TM3 101 3.31x31 C5a1 receptor 5O9H Y1 receptor 5ZBH
TM3 102 3.32x32 C5a1 receptor 5O9H S1P1 receptor 3V2Y
TM3 103 3.33x33 C5a1 receptor 5O9H - -
TM3 104 3.34x34 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM3 105 3.35x35 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM3 106 3.36x36 C5a1 receptor 5O9H CCR2 5T1A
TM3 107 3.37x37 C5a1 receptor 5O9H κ receptor 4DJH
TM3 108 3.38x38 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM3 109 3.39x39 C5a1 receptor 5O9H CCR5 5UIW
TM3 110 3.40x40 C5a1 receptor 5O9H Rhodopsin 1GZM
TM3 111 3.41x41 C5a1 receptor 5O9H P2Y12 receptor 4NTJ
TM3 112 3.42x42 C5a1 receptor 5O9H CCR5 5UIW
TM3 113 3.43x43 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM3 114 3.44x44 C5a1 receptor 5O9H OX2 receptor 5WS3
TM3 115 3.45x45 C5a1 receptor 5O9H NOP receptor 5DHG
TM3 116 3.46x46 C5a1 receptor 5O9H - -
TM3 117 3.47x47 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM3 118 3.48x48 C5a1 receptor 5O9H - -
TM3 119 3.49x49 C5a1 receptor 5O9H NTS1 receptor 4BUO
TM3 120 3.50x50 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM3 121 3.51x51 C5a1 receptor 5O9H - -
TM3 122 3.52x52 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM3 123 3.53x53 C5a1 receptor 5O9H H1 receptor 3RZE
TM3 124 3.54x54 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM3 125 3.55x55 C5a1 receptor 5O9H - -
TM3 126 3.56x56 C5a1 receptor 5O9H - -
ICL2 127 34.50x50 C5a1 receptor 5O9H C5a1 receptor 5O9H
ICL2 128 34.51x51 C5a1 receptor 5O9H C5a1 receptor 6C1R
ICL2 129 34.52x52 C5a1 receptor 5O9H C5a1 receptor 5O9H
ICL2 130 34.53x53 C5a1 receptor 5O9H A1 receptor 5UEN
ICL2 131 34.54x54 C5a1 receptor 5O9H M3 receptor 4U15
ICL2 132 34.55x55 C5a1 receptor 5O9H - -
ICL2 133 34.56x56 C5a1 receptor 5O9H - -
ICL2 134 34.57x57 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM4 135 4.38x38 C5a1 receptor 5O9H US28 4XT1
TM4 136 4.39x39 C5a1 receptor 5O9H M2 receptor 3UON
TM4 137 4.40x40 C5a1 receptor 5O9H - -
TM4 138 4.41x41 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM4 139 4.42x42 C5a1 receptor 5O9H CCR9 5LWE
TM4 140 4.43x43 C5a1 receptor 5O9H apelin receptor 5VBL
TM4 141 4.44x44 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM4 142 4.45x45 C5a1 receptor 5O9H μ receptor 4DKL
TM4 143 4.46x46 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM4 144 4.47x47 C5a1 receptor 5O9H μ receptor 4DKL
TM4 145 4.48x48 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM4 146 4.49x49 C5a1 receptor 5O9H apelin receptor 5VBL
TM4 147 4.50x50 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM4 148 4.51x51 C5a1 receptor 5O9H NOP receptor 5DHG
TM4 149 4.52x52 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM4 150 4.53x53 C5a1 receptor 5O9H κ receptor 4DJH
TM4 151 4.54x54 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM4 152 4.55x55 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM4 153 4.56x56 C5a1 receptor 5O9H - -
TM4 154 4.57x57 κ receptor 4DJH AT1 receptor 4ZUD
TM4 155 4.58x58 κ receptor 4DJH κ receptor 4DJH
TM4 156 4.59x59 κ receptor 4DJH AT1 receptor 4ZUD
TM4 157 4.60x60 C5a1 receptor 5O9H - -
TM4 158 4.61x61 C5a1 receptor 5O9H - -
TM4 159 4.62x62 C5a1 receptor 5O9H apelin receptor 5VBL
TM4 160 4.63x63 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM4 161 4.64x64 C5a1 receptor 5O9H - -
ECL2 162 - - - -
ECL2 163 - - - -
ECL2 164 - - - -
ECL2 165 - - - -
ECL2 166 - - - -
ECL2 167 - - - -
ECL2 168 - - - -
ECL2 169 - - - -
ECL2 170 - - - -
ECL2 171 - - - -
ECL2 172 - - - -
TM5 173 5.34x34 C5a1 receptor 5O9H - -
TM5 174 5.35x35 C5a1 receptor 5O9H - -
TM5 175 5.36x36 C5a1 receptor 5O9H - -
TM5 176 5.37x37 C5a1 receptor 5O9H LPA6 receptor 5XSZ
TM5 177 5.38x38 C5a1 receptor 5O9H D3 receptor 3PBL
TM5 178 5.39x39 C5a1 receptor 5O9H CXCR4 3ODU
TM5 179 5.40x40 C5a1 receptor 5O9H NTS1 receptor 4BUO
TM5 180 5.41x41 C5a1 receptor 5O9H Y1 receptor 5ZBH
TM5 181 5.42x42 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM5 182 5.43x43 C5a1 receptor 5O9H - -
TM5 183 5.44x44 C5a1 receptor 5O9H - -
TM5 184 5.45x45 C5a1 receptor 5O9H δ receptor 4N6H
TM5 185 5.46x46 PAR1 3VW7 H1 receptor 3RZE
TM5 186 5.47x47 PAR1 3VW7 PAR1 3VW7
TM5 187 5.48x48 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM5 188 5.49x49 C5a1 receptor 5O9H - -
TM5 189 5.50x50 C5a1 receptor 5O9H PAF receptor 5ZKP
TM5 190 5.51x51 C5a1 receptor 5O9H κ receptor 4DJH
TM5 191 5.52x52 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM5 192 5.53x53 C5a1 receptor 5O9H - -
TM5 193 5.54x54 C5a1 receptor 5O9H - -
TM5 194 5.55x55 C5a1 receptor 5O9H NOP receptor 5DHG
TM5 195 5.56x56 C5a1 receptor 5O9H CXCR4 3ODU
TM5 196 5.57x57 C5a1 receptor 5O9H NTS1 receptor 4BUO
TM5 197 5.58x58 C5a1 receptor 5O9H - -
TM5 198 5.59x59 C5a1 receptor 5O9H A1 receptor 5UEN
TM5 199 5.60x60 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM5 200 5.61x61 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM5 201 5.62x62 C5a1 receptor 5O9H AT2 receptor 5UNG
TM5 202 5.63x63 C5a1 receptor 5O9H Y1 receptor 5ZBH
TM5 203 5.64x64 C5a1 receptor 5O9H A1 receptor 5UEN
TM5 204 5.65x65 C5a1 receptor 5O9H - -
TM5 205 5.66x66 C5a1 receptor 5O9H - -
TM5 206 5.67x67 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM5 207 5.68x68 C5a1 receptor 5O9H C5a1 receptor 6C1R
ICL3 208 - - - -
ICL3 209 - - - -
ICL3 210 - - - -
TM6 211 6.30x30 AT1 receptor 4YAY κ receptor 4DJH
TM6 212 6.31x31 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM6 213 6.32x32 C5a1 receptor 5O9H δ receptor 4N6H
TM6 214 6.33x33 C5a1 receptor 5O9H apelin receptor 5VBL
TM6 215 6.34x34 C5a1 receptor 5O9H - -
TM6 216 6.35x35 C5a1 receptor 5O9H - -
TM6 217 6.36x36 C5a1 receptor 5O9H CXCR4 3ODU
TM6 218 6.37x37 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM6 219 6.38x38 C5a1 receptor 5O9H κ receptor 4DJH
TM6 220 6.39x39 C5a1 receptor 5O9H A1 receptor 5UEN
TM6 221 6.40x40 C5a1 receptor 5O9H PAR2 5NDD
TM6 222 6.41x41 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM6 223 6.42x42 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM6 224 6.43x43 C5a1 receptor 5O9H κ receptor 4DJH
TM6 225 6.44x44 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM6 226 6.45x45 C5a1 receptor 5O9H 5-HT2C receptor 6BQH
TM6 227 6.46x46 C5a1 receptor 5O9H apelin receptor 5VBL
TM6 228 6.47x47 C5a1 receptor 5O9H κ receptor 4DJH
TM6 229 6.48x48 C5a1 receptor 5O9H FFA1 receptor 5KW2
TM6 230 6.49x49 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM6 231 6.50x50 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM6 232 6.51x51 C5a1 receptor 5O9H 5-HT2C receptor 6BQH
TM6 233 6.52x52 C5a1 receptor 5O9H - -
TM6 234 6.53x53 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM6 235 6.54x54 C5a1 receptor 5O9H - -
TM6 236 6.55x55 C5a1 receptor 5O9H H1 receptor 3RZE
TM6 237 6.56x56 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM6 238 6.57x57 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM6 239 6.58x58 C5a1 receptor 5O9H NTS1 receptor 4BUO
TM6 240 6.59x59 C5a1 receptor 5O9H A1 receptor 5UEN
TM6 241 6.60x60 C5a1 receptor 5O9H Y1 receptor 5ZBH
TM6 242 6.61x61 C5a1 receptor 5O9H μ receptor 4DKL
ECL3 243 - - - -
ECL3 244 μ receptor 5C1M - -
ECL3 245 μ receptor 5C1M - -
ECL3 246 - - - -
TM7 247 7.28x27 C5a1 receptor 5O9H CXCR4 3ODU
TM7 248 7.29x28 C5a1 receptor 5O9H - -
TM7 249 7.30x29 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 250 7.31x30 C5a1 receptor 5O9H - -
TM7 251 7.32x31 C5a1 receptor 5O9H - -
TM7 252 7.33x32 C5a1 receptor 5O9H H1 receptor 3RZE
TM7 253 7.34x33 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM7 254 7.35x34 C5a1 receptor 5O9H H1 receptor 3RZE
TM7 255 7.36x35 C5a1 receptor 5O9H Y1 receptor 5ZBH
TM7 256 7.37x36 C5a1 receptor 5O9H CCR9 5LWE
TM7 257 7.38x37 C5a1 receptor 5O9H OX2 receptor 5WS3
TM7 258 7.39x38 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM7 259 7.40x39 C5a1 receptor 5O9H A1 receptor 5UEN
TM7 260 7.41x40 C5a1 receptor 5O9H κ receptor 4DJH
TM7 261 7.42x41 C5a1 receptor 5O9H apelin receptor 5VBL
TM7 262 7.43x42 C5a1 receptor 5O9H FFA1 receptor 5TZY
TM7 263 7.44x43 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM7 264 7.45x45 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 265 7.46x46 C5a1 receptor 5O9H κ receptor 4DJH
TM7 266 7.47x47 C5a1 receptor 5O9H κ receptor 4DJH
TM7 267 7.48x48 C5a1 receptor 5O9H ETB receptor 5X93
TM7 268 7.49x49 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 269 7.50x50 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 270 7.51x51 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 271 7.52x52 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 272 7.53x53 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 273 7.54x54 C5a1 receptor 5O9H P2Y1 receptor 4XNW
TM7 274 7.55x55 C5a1 receptor 5O9H κ receptor 4DJH
TM7 275 7.56x56 C5a1 receptor 5O9H CCR9 5LWE
H8 276 8.47x47 PAR2 5NDD CCR9 5LWE
H8 277 8.48x48 PAR2 5NDD - -
H8 278 8.49x49 PAR2 5NDD - -
H8 279 8.50x50 PAR2 5NDD - -
H8 280 8.51x51 PAR2 5NDD Y1 receptor 5ZBH
H8 281 8.52x52 PAR2 5NDD κ receptor 4DJH
H8 282 8.53x53 PAR2 5NDD OX1 receptor 4ZJ8
H8 283 8.54x54 PAR2 5NDD - -
H8 284 8.55x55 PAR2 5NDD δ receptor 4RWD
H8 285 8.56x56 PAR2 5NDD LPA1 receptor 4Z36
H8 286 8.57x57 PAR2 5NDD - -
H8 287 8.58x58 PAR2 5NDD PAR2 5NDD
H8 288 8.59x59 apelin receptor 5VBL CCR9 5LWE
H8 289 8.60x60 apelin receptor 5VBL - -
H8 290 8.61x61 apelin receptor 5VBL - -
C-term 291 - - - -
C-term 292 - - - -
C-term 293 - - - -
C-term 294 - - - -
C-term 295 - - - -