MRGPRX2 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive (Δ distance (Å): -1.44 docs)

VERSION

2018-07-10

MAIN TEMPLATE

C5a1 receptor (sequence similarity: 42%) PDB: 5O9H

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 81.4 9.6 8.9
Side-chains 19.3 51.8 28.9

Number of backbone templates: 6
Number of rotamer templates: 38

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5O9H
5NDD
4XNW
5XRA
5C1M
4XT1
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 23 - - - -
N-term 24 - - - -
N-term 25 C5a1 receptor 5O9H C5a1 receptor 5O9H
N-term 26 C5a1 receptor 5O9H C5a1 receptor 5O9H
N-term 27 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 28 1.30x30 C5a1 receptor 5O9H - -
TM1 29 1.31x31 C5a1 receptor 5O9H M4 receptor 5DSG
TM1 30 1.32x32 C5a1 receptor 5O9H PAR2 5NDD
TM1 31 1.33x33 C5a1 receptor 5O9H CB1 receptor 5U09
TM1 32 1.34x34 C5a1 receptor 5O9H κ receptor 4DJH
TM1 33 1.35x35 C5a1 receptor 5O9H - -
TM1 34 1.36x36 C5a1 receptor 5O9H NOP receptor 5DHG
TM1 35 1.37x37 C5a1 receptor 5O9H M3 receptor 4U15
TM1 36 1.38x38 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM1 37 1.39x39 C5a1 receptor 5O9H 5-HT2C receptor 6BQH
TM1 38 1.40x40 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM1 39 1.41x41 C5a1 receptor 5O9H M3 receptor 4U15
TM1 40 1.42x42 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM1 41 1.43x43 C5a1 receptor 5O9H A1 receptor 5UEN
TM1 42 1.44x44 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 43 1.45x45 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 44 1.46x46 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 45 1.47x47 C5a1 receptor 5O9H μ receptor 4DKL
TM1 46 1.48x48 C5a1 receptor 5O9H CXCR4 3ODU
TM1 47 1.49x49 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 48 1.50x50 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 49 1.51x51 C5a1 receptor 5O9H CXCR4 3ODU
TM1 50 1.52x52 C5a1 receptor 5O9H BLT1 receptor 5X33
TM1 51 1.53x53 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 52 1.54x54 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM1 53 1.55x55 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 54 1.56x56 C5a1 receptor 5O9H AT2 receptor 5UNG
TM1 55 1.57x57 C5a1 receptor 5O9H NTS1 receptor 4BUO
TM1 56 1.58x58 C5a1 receptor 5O9H CXCR4 3ODU
TM1 57 1.59x59 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM1 58 1.60x60 C5a1 receptor 5O9H PAR2 5NDD
ICL1 59 C5a1 receptor 5O9H - -
ICL1 60 C5a1 receptor 5O9H - -
ICL1 61 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM2 62 2.37x37 C5a1 receptor 5O9H 5-HT2C receptor 6BQH
TM2 63 2.38x38 C5a1 receptor 5O9H μ receptor 4DKL
TM2 64 2.39x39 C5a1 receptor 5O9H P2Y12 receptor 4NTJ
TM2 65 2.40x40 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM2 66 2.41x41 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM2 67 2.42x42 C5a1 receptor 5O9H CXCR4 3ODU
TM2 68 2.43x43 C5a1 receptor 5O9H BLT1 receptor 5X33
TM2 69 2.44x44 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM2 70 2.45x45 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM2 71 2.46x46 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM2 72 2.47x47 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM2 73 2.48x48 C5a1 receptor 5O9H - -
TM2 74 2.49x49 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM2 75 2.50x50 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM2 76 2.51x51 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM2 77 2.52x52 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM2 78 2.53x53 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM2 79 2.54x54 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM2 80 2.55x55 C5a1 receptor 5O9H US28 4XT1
TM2 81 2.56x56 C5a1 receptor 5O9H - -
TM2 82 2.57x57 C5a1 receptor 5O9H - -
TM2 83 2.58x58 C5a1 receptor 5O9H - -
TM2 84 2.59x59 C5a1 receptor 5O9H C5a1 receptor 6C1R
TM2 85 2.60x60 C5a1 receptor 5O9H H1 receptor 3RZE
TM2 86 2.61x61 C5a1 receptor 5O9H - -
TM2 87 2.62x62 C5a1 receptor 5O9H A1 receptor 5UEN
TM2 88 2.63x63 C5a1 receptor 5O9H κ receptor 4DJH
TM2 89 2.64x64 C5a1 receptor 5O9H μ receptor 4DKL
TM2 90 2.65x65 C5a1 receptor 5O9H μ receptor 4DKL
TM2 91 2.66x66 C5a1 receptor 5O9H PAR1 3VW7
ECL1 92 - - - -
ECL1 93 PAR2 5NDD - -
ECL1 94 PAR2 5NDD - -
ECL1 95 PAR2 5NDD - -
ECL1 96 PAR2 5NDD - -
ECL1 97 - - - -
TM3 98 3.21x21 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM3 99 3.22x22 C5a1 receptor 5O9H - -
TM3 100 3.23x23 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM3 101 3.24x24 C5a1 receptor 5O9H apelin receptor 5VBL
TM3 102 3.25x25 C5a1 receptor 5O9H - -
TM3 103 3.26x26 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM3 104 3.27x27 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM3 105 3.28x28 C5a1 receptor 5O9H D2 receptor 6CM4
TM3 106 3.29x29 C5a1 receptor 5O9H β2-adrenoceptor 5JQH
TM3 107 3.30x30 C5a1 receptor 5O9H D2 receptor 6CM4
TM3 108 3.31x31 C5a1 receptor 5O9H Y1 receptor 5ZBH
TM3 109 3.32x32 C5a1 receptor 5O9H S1P1 receptor 3V2Y
TM3 110 3.33x33 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM3 111 3.34x34 C5a1 receptor 5O9H PAR1 3VW7
TM3 112 3.35x35 C5a1 receptor 5O9H H1 receptor 3RZE
TM3 113 3.36x36 C5a1 receptor 5O9H CCR2 5T1A
TM3 114 3.37x37 C5a1 receptor 5O9H - -
TM3 115 3.38x38 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM3 116 3.39x39 C5a1 receptor 5O9H CCR5 5UIW
TM3 117 3.40x40 C5a1 receptor 5O9H Rhodopsin 1GZM
TM3 118 3.41x41 C5a1 receptor 5O9H P2Y12 receptor 4NTJ
TM3 119 3.42x42 C5a1 receptor 5O9H - -
TM3 120 3.43x43 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM3 121 3.44x44 C5a1 receptor 5O9H OX1 receptor 4ZJ8
TM3 122 3.45x45 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM3 123 3.46x46 C5a1 receptor 5O9H - -
TM3 124 3.47x47 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM3 125 3.48x48 C5a1 receptor 5O9H - -
TM3 126 3.49x49 C5a1 receptor 5O9H NTS1 receptor 4BUO
TM3 127 3.50x50 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM3 128 3.51x51 C5a1 receptor 5O9H - -
TM3 129 3.52x52 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM3 130 3.53x53 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM3 131 3.54x54 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM3 132 3.55x55 C5a1 receptor 5O9H - -
TM3 133 3.56x56 C5a1 receptor 5O9H - -
ICL2 134 34.50x50 C5a1 receptor 5O9H C5a1 receptor 5O9H
ICL2 135 34.51x51 C5a1 receptor 5O9H C5a1 receptor 6C1R
ICL2 136 34.52x52 C5a1 receptor 5O9H C5a1 receptor 5O9H
ICL2 137 34.53x53 C5a1 receptor 5O9H CB1 receptor 5TGZ
ICL2 138 34.54x54 C5a1 receptor 5O9H M3 receptor 4U15
ICL2 139 34.55x55 C5a1 receptor 5O9H - -
ICL2 140 34.56x56 C5a1 receptor 5O9H P2Y1 receptor 4XNW
ICL2 141 34.57x57 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM4 142 4.38x38 C5a1 receptor 5O9H US28 4XT1
TM4 143 4.39x39 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM4 144 4.40x40 C5a1 receptor 5O9H - -
TM4 145 4.41x41 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM4 146 4.42x42 C5a1 receptor 5O9H CCR9 5LWE
TM4 147 4.43x43 C5a1 receptor 5O9H apelin receptor 5VBL
TM4 148 4.44x44 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM4 149 4.45x45 C5a1 receptor 5O9H CXCR4 3ODU
TM4 150 4.46x46 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM4 151 4.47x47 C5a1 receptor 5O9H CXCR4 3ODU
TM4 152 4.48x48 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM4 153 4.49x49 C5a1 receptor 5O9H apelin receptor 5VBL
TM4 154 4.50x50 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM4 155 4.51x51 C5a1 receptor 5O9H OX1 receptor 4ZJ8
TM4 156 4.52x52 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM4 157 4.53x53 C5a1 receptor 5O9H NTS1 receptor 4BUO
TM4 158 4.54x54 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM4 159 4.55x55 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM4 160 4.56x56 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM4 161 4.57x57 P2Y1 receptor 4XNW AT1 receptor 4ZUD
TM4 162 4.58x58 P2Y1 receptor 4XNW κ receptor 4DJH
TM4 163 4.59x59 P2Y1 receptor 4XNW AT1 receptor 4ZUD
TM4 164 4.60x60 C5a1 receptor 5O9H - -
TM4 165 4.61x61 C5a1 receptor 5O9H CCR2 5T1A
TM4 166 4.62x62 C5a1 receptor 5O9H - -
TM4 167 4.63x63 C5a1 receptor 5O9H NTS1 receptor 4BUO
TM4 168 4.64x64 C5a1 receptor 5O9H - -
ECL2 169 - - - -
ECL2 170 - - - -
ECL2 171 - - - -
ECL2 172 - - - -
ECL2 173 - - - -
ECL2 174 - - - -
ECL2 175 - - - -
ECL2 176 - - - -
ECL2 177 - - - -
ECL2 178 - - - -
ECL2 179 - - - -
TM5 180 5.34x34 C5a1 receptor 5O9H - -
TM5 181 5.35x35 C5a1 receptor 5O9H - -
TM5 182 5.36x36 C5a1 receptor 5O9H - -
TM5 183 5.37x37 C5a1 receptor 5O9H PAR2 5NDD
TM5 184 5.38x38 C5a1 receptor 5O9H D3 receptor 3PBL
TM5 185 5.39x39 C5a1 receptor 5O9H CXCR4 3ODU
TM5 186 5.40x40 C5a1 receptor 5O9H NTS1 receptor 4BUO
TM5 187 5.41x41 C5a1 receptor 5O9H Y1 receptor 5ZBH
TM5 188 5.42x42 C5a1 receptor 5O9H β2-adrenoceptor 5JQH
TM5 189 5.43x43 C5a1 receptor 5O9H - -
TM5 190 5.44x44 C5a1 receptor 5O9H - -
TM5 191 5.45x45 C5a1 receptor 5O9H δ receptor 4N6H
TM5 192 5.46x46 CB1 receptor 5XRA H1 receptor 3RZE
TM5 193 5.47x47 CB1 receptor 5XRA C5a1 receptor 5O9H
TM5 194 5.48x48 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM5 195 5.49x49 C5a1 receptor 5O9H NTS1 receptor 4BUO
TM5 196 5.50x50 C5a1 receptor 5O9H - -
TM5 197 5.51x51 C5a1 receptor 5O9H μ receptor 4DKL
TM5 198 5.52x52 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM5 199 5.53x53 C5a1 receptor 5O9H - -
TM5 200 5.54x54 C5a1 receptor 5O9H - -
TM5 201 5.55x55 C5a1 receptor 5O9H NTS1 receptor 4BUO
TM5 202 5.56x56 C5a1 receptor 5O9H CXCR4 3ODU
TM5 203 5.57x57 C5a1 receptor 5O9H NTS1 receptor 4BUO
TM5 204 5.58x58 C5a1 receptor 5O9H - -
TM5 205 5.59x59 C5a1 receptor 5O9H A1 receptor 5UEN
TM5 206 5.60x60 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM5 207 5.61x61 C5a1 receptor 5O9H A1 receptor 5UEN
TM5 208 5.62x62 C5a1 receptor 5O9H AT2 receptor 5UNG
TM5 209 5.63x63 C5a1 receptor 5O9H D2 receptor 6CM4
TM5 210 5.64x64 C5a1 receptor 5O9H A1 receptor 5UEN
TM5 211 5.65x65 C5a1 receptor 5O9H - -
TM5 212 5.66x66 C5a1 receptor 5O9H - -
TM5 213 5.67x67 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM5 214 5.68x68 C5a1 receptor 5O9H C5a1 receptor 6C1R
ICL3 215 - - - -
ICL3 216 - - - -
ICL3 217 - - - -
TM6 218 6.30x30 PAR2 5NDD NTS1 receptor 4BUO
TM6 219 6.31x31 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM6 220 6.32x32 C5a1 receptor 5O9H CB1 receptor 5U09
TM6 221 6.33x33 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM6 222 6.34x34 C5a1 receptor 5O9H - -
TM6 223 6.35x35 C5a1 receptor 5O9H NTS1 receptor 4BUO
TM6 224 6.36x36 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM6 225 6.37x37 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM6 226 6.38x38 C5a1 receptor 5O9H μ receptor 4DKL
TM6 227 6.39x39 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM6 228 6.40x40 C5a1 receptor 5O9H PAR2 5NDD
TM6 229 6.41x41 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM6 230 6.42x42 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM6 231 6.43x43 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM6 232 6.44x44 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM6 233 6.45x45 C5a1 receptor 5O9H 5-HT2C receptor 6BQH
TM6 234 6.46x46 C5a1 receptor 5O9H apelin receptor 5VBL
TM6 235 6.47x47 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM6 236 6.48x48 C5a1 receptor 5O9H FFA1 receptor 5KW2
TM6 237 6.49x49 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM6 238 6.50x50 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM6 239 6.51x51 C5a1 receptor 5O9H D2 receptor 6CM4
TM6 240 6.52x52 C5a1 receptor 5O9H - -
TM6 241 6.53x53 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM6 242 6.54x54 C5a1 receptor 5O9H - -
TM6 243 6.55x55 C5a1 receptor 5O9H - -
TM6 244 6.56x56 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM6 245 6.57x57 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM6 246 6.58x58 C5a1 receptor 5O9H H1 receptor 3RZE
TM6 247 6.59x59 C5a1 receptor 5O9H A1 receptor 5UEN
TM6 248 6.60x60 C5a1 receptor 5O9H Y1 receptor 5ZBH
TM6 249 6.61x61 C5a1 receptor 5O9H NTS1 receptor 4BUO
ECL3 250 - - - -
ECL3 251 μ receptor 5C1M - -
ECL3 252 μ receptor 5C1M - -
ECL3 253 - - - -
TM7 254 7.28x27 C5a1 receptor 5O9H apelin receptor 5VBL
TM7 255 7.29x28 C5a1 receptor 5O9H - -
TM7 256 7.30x29 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 257 7.31x30 C5a1 receptor 5O9H - -
TM7 258 7.32x31 C5a1 receptor 5O9H - -
TM7 259 7.33x32 C5a1 receptor 5O9H H1 receptor 3RZE
TM7 260 7.34x33 C5a1 receptor 5O9H apelin receptor 5VBL
TM7 261 7.35x34 C5a1 receptor 5O9H H1 receptor 3RZE
TM7 262 7.36x35 C5a1 receptor 5O9H AT1 receptor 4ZUD
TM7 263 7.37x36 C5a1 receptor 5O9H BLT1 receptor 5X33
TM7 264 7.38x37 C5a1 receptor 5O9H OX1 receptor 4ZJ8
TM7 265 7.39x38 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 266 7.40x39 C5a1 receptor 5O9H A2A receptor 3VG9
TM7 267 7.41x40 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM7 268 7.42x41 C5a1 receptor 5O9H apelin receptor 5VBL
TM7 269 7.43x42 C5a1 receptor 5O9H ETB receptor 5X93
TM7 270 7.44x43 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM7 271 7.45x45 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 272 7.46x46 C5a1 receptor 5O9H CB1 receptor 5TGZ
TM7 273 7.47x47 C5a1 receptor 5O9H κ receptor 4DJH
TM7 274 7.48x48 C5a1 receptor 5O9H OX1 receptor 4ZJ8
TM7 275 7.49x49 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 276 7.50x50 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 277 7.51x51 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 278 7.52x52 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 279 7.53x53 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 280 7.54x54 C5a1 receptor 5O9H P2Y1 receptor 4XNW
TM7 281 7.55x55 C5a1 receptor 5O9H apelin receptor 5VBL
TM7 282 7.56x56 C5a1 receptor 5O9H NTS1 receptor 4BUO
H8 283 8.47x47 PAR2 5NDD CCR5 5UIW
H8 284 8.48x48 PAR2 5NDD - -
H8 285 8.49x49 PAR2 5NDD - -
H8 286 8.50x50 PAR2 5NDD - -
H8 287 8.51x51 PAR2 5NDD μ receptor 4DKL
H8 288 8.52x52 PAR2 5NDD apelin receptor 5VBL
H8 289 8.53x53 PAR2 5NDD - -
H8 290 8.54x54 PAR2 5NDD - -
H8 291 8.55x55 PAR2 5NDD NTS1 receptor 4BUO
H8 292 8.56x56 PAR2 5NDD LPA1 receptor 4Z36
H8 293 8.57x57 PAR2 5NDD - -
H8 294 8.58x58 PAR2 5NDD - -
H8 295 8.59x59 US28 4XT1 μ receptor 4DKL
H8 296 8.60x60 US28 4XT1 - -
H8 297 8.61x61 US28 4XT1 - -
C-term 298 - - - -
C-term 299 - - - -
C-term 300 - - - -
C-term 301 - - - -
C-term 302 - - - -