MRGPRX2 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate (Δ distance (Å): 7.11 docs)

VERSION

2018-07-10

MAIN TEMPLATE

PAR2 (sequence similarity: 41%) PDB: 5NDD

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 79.6 9.6 10.7
Side-chains 17.1 52.5 30.4

Number of backbone templates: 7
Number of rotamer templates: 39

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5NDD
5NDZ
5O9H
4XNW
5XRA
5C1M
4XT1
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 23 PAR2 5NDD PAR2 5NDD
N-term 24 PAR2 5NDD PAR2 5NDD
N-term 25 PAR2 5NDD PAR2 5NDD
N-term 26 PAR2 5NDD PAR2 5NDD
N-term 27 PAR2 5NDD PAR2 5NDD
TM1 28 1.30x30 PAR2 5NDD - -
TM1 29 1.31x31 PAR2 5NDD M4 receptor 5DSG
TM1 30 1.32x32 PAR2 5NDD PAR2 5NDD
TM1 31 1.33x33 PAR2 5NDD PAR1 3VW7
TM1 32 1.34x34 PAR2 5NDD κ receptor 4DJH
TM1 33 1.35x35 PAR2 5NDD - -
TM1 34 1.36x36 PAR2 5NDD 5-HT1B receptor 4IAQ
TM1 35 1.37x37 PAR2 5NDD US28 4XT1
TM1 36 1.38x38 PAR2 5NDD 5-HT1B receptor 4IAQ
TM1 37 1.39x39 PAR2 5NDD 5-HT2C receptor 6BQH
TM1 38 1.40x40 PAR2 5NDD NTS1 receptor 4XES
TM1 39 1.41x41 PAR2 5NDD M3 receptor 4U15
TM1 40 1.42x42 PAR2 5NDD 5-HT1B receptor 4IAQ
TM1 41 1.43x43 PAR2 5NDD A2A receptor 4UHR
TM1 42 1.44x44 PAR2 5NDD 5-HT1B receptor 4IAQ
TM1 43 1.45x45 PAR2 5NDD PAR2 5NDD
TM1 44 1.46x46 PAR2 5NDD P2Y1 receptor 4XNW
TM1 45 1.47x47 PAR2 5NDD PAR2 5NDD
TM1 46 1.48x48 PAR2 5NDD NTS1 receptor 4XES
TM1 47 1.49x49 PAR2 5NDD P2Y1 receptor 4XNW
TM1 48 1.50x50 PAR2 5NDD PAR2 5NDD
TM1 49 1.51x51 PAR2 5NDD PAR2 5NDD
TM1 50 1.52x52 PAR2 5NDD 5-HT1B receptor 4IAQ
TM1 51 1.53x53 PAR2 5NDD μ receptor 6DDE
TM1 52 1.54x54 PAR2 5NDD PAR2 5NDD
TM1 53 1.55x55 PAR2 5NDD PAR2 5NDD
TM1 54 1.56x56 PAR2 5NDD AT2 receptor 5UNG
TM1 55 1.57x57 PAR2 5NDD NTS1 receptor 4XES
TM1 56 1.58x58 PAR2 5NDD CXCR4 3ODU
TM1 57 1.59x59 PAR2 5NDD PAR2 5NDD
TM1 58 1.60x60 PAR2 5NDD PAR2 5NDD
ICL1 59 - - - -
ICL1 60 C5a1 receptor 5O9H - -
ICL1 61 - - - -
TM2 62 2.37x37 PAR2 5NDD A2A receptor 4UHR
TM2 63 2.38x38 PAR2 5NDD μ receptor 6DDE
TM2 64 2.39x39 PAR2 5NDD P2Y12 receptor 4NTJ
TM2 65 2.40x40 PAR2 5NDD P2Y1 receptor 4XNW
TM2 66 2.41x41 PAR2 5NDD P2Y1 receptor 4XNW
TM2 67 2.42x42 PAR2 5NDD PAR2 5NDD
TM2 68 2.43x43 PAR2 5NDD A2A receptor 4UHR
TM2 69 2.44x44 PAR2 5NDD PAR1 3VW7
TM2 70 2.45x45 PAR2 5NDD NTS1 receptor 4XES
TM2 71 2.46x46 PAR2 5NDD PAR2 5NDD
TM2 72 2.47x47 PAR2 5NDD PAR2 5NDD
TM2 73 2.48x48 PAR2 5NDD - -
TM2 74 2.49x49 PAR2 5NDD PAR2 5NDD
TM2 75 2.50x50 PAR2 5NDD PAR2 5NDD
TM2 76 2.51x51 PAR2 5NDD P2Y1 receptor 4XNW
TM2 77 2.52x52 PAR2 5NDD PAR2 5NDD
TM2 78 2.53x53 PAR2 5NDD PAR1 3VW7
TM2 79 2.54x54 PAR2 5NDD NTS1 receptor 4XES
TM2 80 2.55x55 PAR2 5NDD US28 4XT1
TM2 81 2.56x56 PAR2 5NDD - -
TM2 82 2.57x57 PAR2 5NDD - -
TM2 83 2.58x58 PAR2 5NDD - -
TM2 84 2.59x59 PAR2 5NDD 5-HT1B receptor 4IAQ
TM2 85 2.60x60 PAR2 5NDD H1 receptor 3RZE
TM2 86 2.61x61 PAR2 5NDD - -
TM2 87 2.62x62 PAR2 5NDD 5-HT2B receptor 4IB4
TM2 88 2.63x63 PAR2 5NDD κ receptor 4DJH
TM2 89 2.64x64 PAR2 5NDD P2Y1 receptor 4XNW
TM2 90 2.65x65 PAR2 5NDD FFA1 receptor 5TZY
TM2 91 2.66x66 PAR2 5NDD PAR1 3VW7
ECL1 92 - - - -
ECL1 93 PAR2 5NDZ - -
ECL1 94 PAR2 5NDZ - -
ECL1 95 PAR2 5NDZ - -
ECL1 96 PAR2 5NDZ - -
ECL1 97 - - - -
TM3 98 3.21x21 PAR2 5NDD CB1 receptor 5XRA
TM3 99 3.22x22 PAR2 5NDD - -
TM3 100 3.23x23 PAR2 5NDD CB1 receptor 5XRA
TM3 101 3.24x24 PAR2 5NDD apelin receptor 5VBL
TM3 102 3.25x25 PAR2 5NDD - -
TM3 103 3.26x26 PAR2 5NDD C5a1 receptor 5O9H
TM3 104 3.27x27 PAR2 5NDD PAR1 3VW7
TM3 105 3.28x28 PAR2 5NDD FFA1 receptor 5TZY
TM3 106 3.29x29 PAR2 5NDD PAR1 3VW7
TM3 107 3.30x30 PAR2 5NDD D2 receptor 6CM4
TM3 108 3.31x31 PAR2 5NDD Y1 receptor 5ZBH
TM3 109 3.32x32 PAR2 5NDD S1P1 receptor 3V2Y
TM3 110 3.33x33 PAR2 5NDD AT2 receptor 5UNG
TM3 111 3.34x34 PAR2 5NDD PAR1 3VW7
TM3 112 3.35x35 PAR2 5NDD US28 4XT1
TM3 113 3.36x36 PAR2 5NDD CCR2 5T1A
TM3 114 3.37x37 PAR2 5NDD - -
TM3 115 3.38x38 PAR2 5NDD PAR1 3VW7
TM3 116 3.39x39 PAR2 5NDD FFA1 receptor 5TZY
TM3 117 3.40x40 PAR2 5NDD US28 4XT1
TM3 118 3.41x41 PAR2 5NDD P2Y12 receptor 4NTJ
TM3 119 3.42x42 PAR2 5NDD - -
TM3 120 3.43x43 PAR2 5NDD PAR2 5NDD
TM3 121 3.44x44 PAR2 5NDD OX1 receptor 4ZJ8
TM3 122 3.45x45 PAR2 5NDD μ receptor 6DDE
TM3 123 3.46x46 PAR2 5NDD - -
TM3 124 3.47x47 PAR2 5NDD PAR2 5NDD
TM3 125 3.48x48 PAR2 5NDD - -
TM3 126 3.49x49 PAR2 5NDD NTS1 receptor 4XEE
TM3 127 3.50x50 PAR2 5NDD PAR2 5NDD
TM3 128 3.51x51 PAR2 5NDD - -
TM3 129 3.52x52 PAR2 5NDD PAR1 3VW7
TM3 130 3.53x53 PAR2 5NDD AT2 receptor 5UNG
TM3 131 3.54x54 PAR2 5NDD P2Y1 receptor 4XNW
TM3 132 3.55x55 PAR2 5NDD - -
TM3 133 3.56x56 PAR2 5NDD - -
ICL2 134 34.50x50 - - - -
ICL2 135 34.51x51 C5a1 receptor 5O9H C5a1 receptor 6C1R
ICL2 136 34.52x52 C5a1 receptor 5O9H C5a1 receptor 5O9H
ICL2 137 34.53x53 C5a1 receptor 5O9H 5-HT1B receptor 4IAQ
ICL2 138 34.54x54 C5a1 receptor 5O9H LPA6 receptor 5XSZ
ICL2 139 34.55x55 C5a1 receptor 5O9H - -
ICL2 140 34.56x56 C5a1 receptor 5O9H P2Y1 receptor 4XNW
ICL2 141 34.57x57 - - - -
TM4 142 4.38x38 PAR2 5NDD - -
TM4 143 4.39x39 PAR2 5NDD NTS1 receptor 4XES
TM4 144 4.40x40 PAR2 5NDD - -
TM4 145 4.41x41 PAR2 5NDD C5a1 receptor 5O9H
TM4 146 4.42x42 PAR2 5NDD FFA1 receptor 5TZY
TM4 147 4.43x43 PAR2 5NDD 5-HT1B receptor 4IAQ
TM4 148 4.44x44 PAR2 5NDD 5-HT1B receptor 4IAQ
TM4 149 4.45x45 PAR2 5NDD μ receptor 6DDE
TM4 150 4.46x46 PAR2 5NDD PAR1 3VW7
TM4 151 4.47x47 PAR2 5NDD P2Y1 receptor 4XNW
TM4 152 4.48x48 PAR2 5NDD P2Y1 receptor 4XNW
TM4 153 4.49x49 PAR2 5NDD apelin receptor 5VBL
TM4 154 4.50x50 PAR2 5NDD PAR2 5NDD
TM4 155 4.51x51 PAR2 5NDD PAR1 3VW7
TM4 156 4.52x52 PAR2 5NDD PAR2 5NDD
TM4 157 4.53x53 PAR2 5NDD NTS1 receptor 4XES
TM4 158 4.54x54 PAR2 5NDD PAR2 5NDD
TM4 159 4.55x55 PAR2 5NDD PAR2 5NDD
TM4 160 4.56x56 PAR2 5NDD NTS1 receptor 4XES
TM4 161 4.57x57 P2Y1 receptor 4XNW 5-HT1B receptor 4IAQ
TM4 162 4.58x58 P2Y1 receptor 4XNW κ receptor 4DJH
TM4 163 4.59x59 P2Y1 receptor 4XNW FFA1 receptor 5TZY
TM4 164 4.60x60 PAR2 5NDD - -
TM4 165 4.61x61 PAR2 5NDD LPA6 receptor 5XSZ
TM4 166 4.62x62 PAR2 5NDD - -
TM4 167 4.63x63 PAR2 5NDD NTS1 receptor 4XES
TM4 168 4.64x64 C5a1 receptor 5O9H - -
ECL2 169 - - - -
ECL2 170 - - - -
ECL2 171 - - - -
ECL2 172 - - - -
ECL2 173 - - - -
ECL2 174 - - - -
ECL2 175 - - - -
ECL2 176 - - - -
ECL2 177 - - - -
ECL2 178 - - - -
ECL2 179 - - - -
TM5 180 5.34x34 PAR2 5NDD - -
TM5 181 5.35x35 PAR2 5NDD - -
TM5 182 5.36x36 PAR2 5NDD - -
TM5 183 5.37x37 PAR2 5NDD PAR2 5NDD
TM5 184 5.38x38 PAR2 5NDD 5-HT2B receptor 4IB4
TM5 185 5.39x39 PAR2 5NDD PAR1 3VW7
TM5 186 5.40x40 PAR2 5NDD NTS1 receptor 4XES
TM5 187 5.41x41 PAR2 5NDD Y1 receptor 5ZBH
TM5 188 5.42x42 PAR2 5NDD β2-adrenoceptor 3SN6
TM5 189 5.43x43 PAR2 5NDD - -
TM5 190 5.44x44 PAR2 5NDD - -
TM5 191 5.45x45 PAR2 5NDD 5-HT2B receptor 4IB4
TM5 192 5.46x46 CB1 receptor 5XRA P2Y12 receptor 4NTJ
TM5 193 5.47x47 CB1 receptor 5XRA PAR2 5NDD
TM5 194 5.48x48 PAR2 5NDD PAR2 5NDD
TM5 195 5.49x49 PAR2 5NDD PAR2 5NDD
TM5 196 5.50x50 PAR2 5NDD - -
TM5 197 5.51x51 PAR2 5NDD μ receptor 6DDE
TM5 198 5.52x52 PAR2 5NDD NTS1 receptor 4XES
TM5 199 5.53x53 PAR2 5NDD - -
TM5 200 5.54x54 PAR2 5NDD - -
TM5 201 5.55x55 PAR2 5NDD NTS1 receptor 4XES
TM5 202 5.56x56 PAR2 5NDD PAR2 5NDD
TM5 203 5.57x57 PAR2 5NDD NTS1 receptor 4XES
TM5 204 5.58x58 PAR2 5NDD - -
TM5 205 5.59x59 PAR2 5NDD A2A receptor 4UHR
TM5 206 5.60x60 PAR2 5NDD PAR2 5NDD
TM5 207 5.61x61 PAR2 5NDD LPA6 receptor 5XSZ
TM5 208 5.62x62 PAR2 5NDD AT2 receptor 5UNG
TM5 209 5.63x63 PAR2 5NDD D2 receptor 6CM4
TM5 210 5.64x64 PAR2 5NDD A1 receptor 5UEN
TM5 211 5.65x65 PAR2 5NDD - -
TM5 212 5.66x66 - - - -
TM5 213 5.67x67 - - - -
TM5 214 5.68x68 - - - -
ICL3 215 - - - -
ICL3 216 - - - -
ICL3 217 - - - -
TM6 218 6.30x30 PAR2 5NDD P2Y1 receptor 4XNW
TM6 219 6.31x31 PAR2 5NDD C5a1 receptor 6C1R
TM6 220 6.32x32 PAR2 5NDD P2Y1 receptor 4XNW
TM6 221 6.33x33 PAR2 5NDD FFA1 receptor 5KW2
TM6 222 6.34x34 PAR2 5NDD - -
TM6 223 6.35x35 PAR2 5NDD PAR1 3VW7
TM6 224 6.36x36 PAR2 5NDD 5-HT1B receptor 4IAQ
TM6 225 6.37x37 PAR2 5NDD AT1 receptor 4ZUD
TM6 226 6.38x38 PAR2 5NDD μ receptor 6DDE
TM6 227 6.39x39 PAR2 5NDD CB1 receptor 5XRA
TM6 228 6.40x40 PAR2 5NDD PAR2 5NDD
TM6 229 6.41x41 PAR2 5NDD PAR2 5NDD
TM6 230 6.42x42 PAR2 5NDD P2Y1 receptor 4XNW
TM6 231 6.43x43 PAR2 5NDD μ receptor 6DDE
TM6 232 6.44x44 PAR2 5NDD NTS1 receptor 4XES
TM6 233 6.45x45 PAR2 5NDD 5-HT2B receptor 4IB4
TM6 234 6.46x46 C5a1 receptor 5O9H PAR2 5NDD
TM6 235 6.47x47 C5a1 receptor 5O9H PAR2 5NDD
TM6 236 6.48x48 PAR2 5NDD FFA1 receptor 5KW2
TM6 237 6.49x49 PAR2 5NDD NTS1 receptor 4XES
TM6 238 6.50x50 PAR2 5NDD PAR2 5NDD
TM6 239 6.51x51 PAR2 5NDD P2Y1 receptor 4XNW
TM6 240 6.52x52 PAR2 5NDD - -
TM6 241 6.53x53 PAR2 5NDD μ receptor 6DDE
TM6 242 6.54x54 PAR2 5NDD - -
TM6 243 6.55x55 PAR2 5NDD - -
TM6 244 6.56x56 PAR2 5NDD AT1 receptor 4ZUD
TM6 245 6.57x57 PAR2 5NDD AT1 receptor 4ZUD
TM6 246 6.58x58 PAR2 5NDD H1 receptor 3RZE
TM6 247 6.59x59 PAR2 5NDD P2Y1 receptor 4XNW
TM6 248 6.60x60 PAR2 5NDD Y1 receptor 5ZBH
TM6 249 6.61x61 PAR2 5NDD NTS1 receptor 4GRV
ECL3 250 - - - -
ECL3 251 μ receptor 5C1M - -
ECL3 252 μ receptor 5C1M - -
ECL3 253 - - - -
TM7 254 7.28x27 C5a1 receptor 5O9H apelin receptor 5VBL
TM7 255 7.29x28 C5a1 receptor 5O9H - -
TM7 256 7.30x29 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 257 7.31x30 PAR2 5NDD - -
TM7 258 7.32x31 PAR2 5NDD - -
TM7 259 7.33x32 PAR2 5NDD H1 receptor 3RZE
TM7 260 7.34x33 PAR2 5NDD 5-HT1B receptor 4IAQ
TM7 261 7.35x34 PAR2 5NDD PAF receptor 5ZKQ
TM7 262 7.36x35 PAR2 5NDD AT1 receptor 4ZUD
TM7 263 7.37x36 PAR2 5NDD PAR2 5NDD
TM7 264 7.38x37 PAR2 5NDD OX1 receptor 4ZJ8
TM7 265 7.39x38 PAR2 5NDD PAR1 3VW7
TM7 266 7.40x39 PAR2 5NDD A2A receptor 4UHR
TM7 267 7.41x40 PAR2 5NDD PAR2 5NDD
TM7 268 7.42x41 PAR2 5NDD PAR2 5NDD
TM7 269 7.43x42 PAR2 5NDD P2Y1 receptor 4XNW
TM7 270 7.44x43 PAR2 5NDD PAR2 5NDD
TM7 271 7.45x45 PAR2 5NDD PAR2 5NDD
TM7 272 7.46x46 PAR2 5NDD PAR2 5NDD
TM7 273 7.47x47 PAR2 5NDD κ receptor 4DJH
TM7 274 7.48x48 PAR2 5NDD OX1 receptor 4ZJ8
TM7 275 7.49x49 PAR2 5NDD P2Y1 receptor 4XNW
TM7 276 7.50x50 PAR2 5NDD PAR2 5NDD
TM7 277 7.51x51 PAR2 5NDD P2Y1 receptor 4XNW
TM7 278 7.52x52 PAR2 5NDD PAR1 3VW7
TM7 279 7.53x53 PAR2 5NDD PAR2 5NDD
TM7 280 7.54x54 PAR2 5NDD P2Y1 receptor 4XNW
TM7 281 7.55x55 PAR2 5NDD PAR2 5NDD
TM7 282 7.56x56 PAR2 5NDD PAR2 5NDD
H8 283 8.47x47 PAR2 5NDD US28 4XT1
H8 284 8.48x48 PAR2 5NDD - -
H8 285 8.49x49 PAR2 5NDD - -
H8 286 8.50x50 PAR2 5NDD - -
H8 287 8.51x51 PAR2 5NDD 5-HT1B receptor 4IAQ
H8 288 8.52x52 PAR2 5NDD 5-HT1B receptor 5V54
H8 289 8.53x53 PAR2 5NDD - -
H8 290 8.54x54 PAR2 5NDD - -
H8 291 8.55x55 PAR2 5NDD NTS1 receptor 4BUO
H8 292 8.56x56 PAR2 5NDD LPA1 receptor 4Z36
H8 293 8.57x57 PAR2 5NDD - -
H8 294 8.58x58 PAR2 5NDD - -
H8 295 8.59x59 US28 4XT1 μ receptor 4DKL
H8 296 8.60x60 US28 4XT1 - -
H8 297 8.61x61 US28 4XT1 - -
C-term 298 - - - -
C-term 299 - - - -
C-term 300 - - - -
C-term 301 - - - -
C-term 302 - - - -