MRGPRX4 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 10.27 docs)

VERSION

2018-07-10

MAIN TEMPLATE

μ receptor (sequence similarity: 41%) PDB: 5C1M

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 78.8 13.3 7.9
Side-chains 20.9 51.1 28.1

Number of backbone templates: 6
Number of rotamer templates: 42

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5NDD
5C1M
5O9H
4DJH
3VW7
4XT1
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 18 PAR2 5NDD PAR2 5NDD
N-term 19 PAR2 5NDD PAR2 5NDD
N-term 20 PAR2 5NDD PAR2 5NDD
N-term 21 PAR2 5NDD PAR2 5NDD
N-term 22 PAR2 5NDD PAR2 5NDD
TM1 23 1.28x28 PAR2 5NDD - -
TM1 24 1.29x29 μ receptor 5C1M - -
TM1 25 1.30x30 μ receptor 5C1M - -
TM1 26 1.31x31 μ receptor 5C1M CB1 receptor 5XRA
TM1 27 1.32x32 μ receptor 5C1M PAR2 5NDD
TM1 28 1.33x33 μ receptor 5C1M CB1 receptor 5XRA
TM1 29 1.34x34 μ receptor 5C1M - -
TM1 30 1.35x35 μ receptor 5C1M PAF receptor 5ZKP
TM1 31 1.36x36 μ receptor 5C1M κ receptor 6B73
TM1 32 1.37x37 μ receptor 5C1M CB1 receptor 5XRA
TM1 33 1.38x38 μ receptor 5C1M μ receptor 5C1M
TM1 34 1.39x39 μ receptor 5C1M M4 receptor 5DSG
TM1 35 1.40x40 μ receptor 5C1M ETB receptor 5X93
TM1 36 1.41x41 μ receptor 5C1M μ receptor 5C1M
TM1 37 1.42x42 μ receptor 5C1M AT2 receptor 5UNG
TM1 38 1.43x43 μ receptor 5C1M M2 receptor 4MQT
TM1 39 1.44x44 μ receptor 5C1M US28 4XT1
TM1 40 1.45x45 μ receptor 5C1M μ receptor 5C1M
TM1 41 1.46x46 μ receptor 5C1M μ receptor 5C1M
TM1 42 1.47x47 μ receptor 5C1M μ receptor 5C1M
TM1 43 1.48x48 μ receptor 5C1M apelin receptor 5VBL
TM1 44 1.49x49 μ receptor 5C1M μ receptor 5C1M
TM1 45 1.50x50 μ receptor 5C1M μ receptor 5C1M
TM1 46 1.51x51 μ receptor 5C1M 5-HT1B receptor 6G79
TM1 47 1.52x52 μ receptor 5C1M AT2 receptor 5UNG
TM1 48 1.53x53 μ receptor 5C1M μ receptor 5C1M
TM1 49 1.54x54 μ receptor 5C1M CB1 receptor 5XRA
TM1 50 1.55x55 μ receptor 5C1M A1 receptor 6D9H
TM1 51 1.56x56 μ receptor 5C1M AT2 receptor 5UNG
TM1 52 1.57x57 μ receptor 5C1M NTS1 receptor 4XES
TM1 53 1.58x58 μ receptor 5C1M CXCR4 3ODU
TM1 54 1.59x59 μ receptor 5C1M CXCR4 3ODU
TM1 55 1.60x60 μ receptor 5C1M US28 4XT1
ICL1 56 - - - -
ICL1 57 C5a1 receptor 5O9H - -
ICL1 58 - - - -
TM2 59 2.37x37 μ receptor 5C1M LPA6 receptor 5XSZ
TM2 60 2.38x38 μ receptor 5C1M μ receptor 5C1M
TM2 61 2.39x39 μ receptor 5C1M NTS1 receptor 4XES
TM2 62 2.40x40 μ receptor 5C1M AT2 receptor 5UNG
TM2 63 2.41x41 μ receptor 5C1M μ receptor 5C1M
TM2 64 2.42x42 μ receptor 5C1M μ receptor 5C1M
TM2 65 2.43x43 μ receptor 5C1M μ receptor 5C1M
TM2 66 2.44x44 μ receptor 5C1M Rhodopsin 5DYS
TM2 67 2.45x45 μ receptor 5C1M μ receptor 5C1M
TM2 68 2.46x46 μ receptor 5C1M μ receptor 5C1M
TM2 69 2.47x47 μ receptor 5C1M μ receptor 5C1M
TM2 70 2.48x48 μ receptor 5C1M US28 4XT1
TM2 71 2.49x49 μ receptor 5C1M μ receptor 5C1M
TM2 72 2.50x50 μ receptor 5C1M μ receptor 5C1M
TM2 73 2.51x51 μ receptor 5C1M C5a1 receptor 5O9H
TM2 74 2.52x52 μ receptor 5C1M μ receptor 5C1M
TM2 75 2.53x53 μ receptor 5C1M LPA6 receptor 5XSZ
TM2 76 2.54x54 μ receptor 5C1M AT2 receptor 5UNG
TM2 77 2.55x55 μ receptor 5C1M μ receptor 5C1M
TM2 78 2.56x56 μ receptor 5C1M - -
TM2 79 2.57x57 μ receptor 5C1M - -
TM2 80 2.58x58 μ receptor 5C1M - -
TM2 81 2.59x59 μ receptor 5C1M 5-HT2B receptor 5TUD
TM2 82 2.60x60 μ receptor 5C1M LPA6 receptor 5XSZ
TM2 83 2.61x61 μ receptor 5C1M NTS1 receptor 5T04
TM2 84 2.62x62 μ receptor 5C1M - -
TM2 85 2.63x63 μ receptor 5C1M D2 receptor 6CM4
TM2 86 2.64x64 μ receptor 5C1M - -
TM2 87 2.65x65 μ receptor 5C1M μ receptor 5C1M
TM2 88 2.66x66 μ receptor 5C1M M2 receptor 4MQT
ECL1 89 μ receptor 5C1M - -
ECL1 90 μ receptor 5C1M μ receptor 5C1M
ECL1 91 μ receptor 5C1M μ receptor 5C1M
ECL1 92 μ receptor 5C1M μ receptor 5C1M
ECL1 93 μ receptor 5C1M μ receptor 5C1M
TM3 94 3.24x24 μ receptor 5C1M - -
TM3 95 3.25x25 μ receptor 5C1M - -
TM3 96 3.26x26 μ receptor 5C1M μ receptor 5C1M
TM3 97 3.27x27 μ receptor 5C1M μ receptor 5C1M
TM3 98 3.28x28 μ receptor 5C1M US28 4XT1
TM3 99 3.29x29 μ receptor 5C1M LPA6 receptor 5XSZ
TM3 100 3.30x30 μ receptor 5C1M μ receptor 5C1M
TM3 101 3.31x31 μ receptor 5C1M Y1 receptor 5ZBH
TM3 102 3.32x32 μ receptor 5C1M S1P1 receptor 3V2Y
TM3 103 3.33x33 μ receptor 5C1M AT2 receptor 5UNG
TM3 104 3.34x34 μ receptor 5C1M AT1 receptor 4ZUD
TM3 105 3.35x35 μ receptor 5C1M FFA1 receptor 5TZY
TM3 106 3.36x36 μ receptor 5C1M CCR2 5T1A
TM3 107 3.37x37 μ receptor 5C1M μ receptor 5C1M
TM3 108 3.38x38 μ receptor 5C1M μ receptor 5C1M
TM3 109 3.39x39 μ receptor 5C1M CCR5 5UIW
TM3 110 3.40x40 μ receptor 5C1M US28 4XT1
TM3 111 3.41x41 μ receptor 5C1M P2Y12 receptor 4NTJ
TM3 112 3.42x42 μ receptor 5C1M - -
TM3 113 3.43x43 μ receptor 5C1M μ receptor 5C1M
TM3 114 3.44x44 μ receptor 5C1M OX2 receptor 5WS3
TM3 115 3.45x45 μ receptor 5C1M A1 receptor 6D9H
TM3 116 3.46x46 μ receptor 5C1M LPA6 receptor 5XSZ
TM3 117 3.47x47 μ receptor 5C1M μ receptor 5C1M
TM3 118 3.48x48 μ receptor 5C1M - -
TM3 119 3.49x49 μ receptor 5C1M NTS1 receptor 5T04
TM3 120 3.50x50 μ receptor 5C1M μ receptor 5C1M
TM3 121 3.51x51 μ receptor 5C1M - -
TM3 122 3.52x52 μ receptor 5C1M LPA6 receptor 5XSZ
TM3 123 3.53x53 μ receptor 5C1M AT2 receptor 5UNG
TM3 124 3.54x54 μ receptor 5C1M μ receptor 5C1M
TM3 125 3.55x55 μ receptor 5C1M - -
TM3 126 3.56x56 μ receptor 5C1M - -
ICL2 127 34.50x50 - - - -
ICL2 128 34.51x51 C5a1 receptor 5O9H C5a1 receptor 6C1R
ICL2 129 34.52x52 C5a1 receptor 5O9H C5a1 receptor 5O9H
ICL2 130 34.53x53 C5a1 receptor 5O9H CB1 receptor 5XRA
ICL2 131 34.54x54 C5a1 receptor 5O9H LPA6 receptor 5XSZ
ICL2 132 34.55x55 C5a1 receptor 5O9H - -
ICL2 133 34.56x56 C5a1 receptor 5O9H P2Y1 receptor 4XNW
ICL2 134 34.57x57 - - - -
TM4 135 4.38x38 μ receptor 5C1M US28 4XT1
TM4 136 4.39x39 μ receptor 5C1M M2 receptor 4MQT
TM4 137 4.40x40 μ receptor 5C1M - -
TM4 138 4.41x41 μ receptor 5C1M C5a1 receptor 5O9H
TM4 139 4.42x42 μ receptor 5C1M CCR9 5LWE
TM4 140 4.43x43 μ receptor 5C1M A1 receptor 6D9H
TM4 141 4.44x44 μ receptor 5C1M CB1 receptor 5XRA
TM4 142 4.45x45 μ receptor 5C1M μ receptor 5C1M
TM4 143 4.46x46 μ receptor 5C1M LPA6 receptor 5XSZ
TM4 144 4.47x47 μ receptor 5C1M μ receptor 5C1M
TM4 145 4.48x48 μ receptor 5C1M AT2 receptor 5UNG
TM4 146 4.49x49 μ receptor 5C1M apelin receptor 5VBL
TM4 147 4.50x50 μ receptor 5C1M μ receptor 5C1M
TM4 148 4.51x51 μ receptor 5C1M C5a1 receptor 5O9H
TM4 149 4.52x52 μ receptor 5C1M μ receptor 5C1M
TM4 150 4.53x53 μ receptor 5C1M μ receptor 5C1M
TM4 151 4.54x54 μ receptor 5C1M LPA6 receptor 5XSZ
TM4 152 4.55x55 μ receptor 5C1M AT2 receptor 5UNG
TM4 153 4.56x56 μ receptor 5C1M - -
TM4 154 4.57x57 μ receptor 5C1M AT2 receptor 5UNG
TM4 155 4.58x58 μ receptor 5C1M - -
TM4 156 4.59x59 μ receptor 5C1M AT2 receptor 5UNG
TM4 157 4.60x60 μ receptor 5C1M - -
TM4 158 4.61x61 μ receptor 5C1M - -
TM4 159 4.62x62 μ receptor 5C1M - -
ECL2 160 - - - -
ECL2 161 - - - -
ECL2 162 - - - -
ECL2 163 - - - -
ECL2 164 - - - -
ECL2 165 - - - -
ECL2 166 - - - -
ECL2 167 - - - -
ECL2 168 - - - -
ECL2 169 - - - -
TM5 170 5.31x31 κ receptor 4DJH apelin receptor 5VBL
TM5 171 5.32x32 μ receptor 5C1M δ receptor 4N6H
TM5 172 5.33x33 μ receptor 5C1M μ receptor 5C1M
TM5 173 5.34x34 μ receptor 5C1M - -
TM5 174 5.35x35 μ receptor 5C1M - -
TM5 175 5.36x36 μ receptor 5C1M - -
TM5 176 5.37x37 μ receptor 5C1M LPA6 receptor 5XSZ
TM5 177 5.38x38 μ receptor 5C1M 5-HT2B receptor 5TUD
TM5 178 5.39x39 μ receptor 5C1M 5-HT2C receptor 6BQG
TM5 179 5.40x40 μ receptor 5C1M NTS1 receptor 5T04
TM5 180 5.41x41 μ receptor 5C1M - -
TM5 181 5.42x42 μ receptor 5C1M NTS1 receptor 5T04
TM5 182 5.43x43 μ receptor 5C1M - -
TM5 183 5.44x44 μ receptor 5C1M - -
TM5 184 5.45x45 μ receptor 5C1M US28 4XT1
TM5 185 5.46x46 PAR1 3VW7 H1 receptor 3RZE
TM5 186 5.47x47 PAR1 3VW7 PAR1 3VW7
TM5 187 5.48x48 μ receptor 5C1M LPA6 receptor 5XSZ
TM5 188 5.49x49 μ receptor 5C1M - -
TM5 189 5.50x50 μ receptor 5C1M PAF receptor 5ZKP
TM5 190 5.51x51 μ receptor 5C1M μ receptor 5C1M
TM5 191 5.52x52 μ receptor 5C1M μ receptor 5C1M
TM5 192 5.53x53 μ receptor 5C1M - -
TM5 193 5.54x54 μ receptor 5C1M BLT1 receptor 5X33
TM5 194 5.55x55 μ receptor 5C1M US28 4XT1
TM5 195 5.56x56 μ receptor 5C1M PAR2 5NDD
TM5 196 5.57x57 μ receptor 5C1M NTS1 receptor 5T04
TM5 197 5.58x58 μ receptor 5C1M - -
TM5 198 5.59x59 μ receptor 5C1M A1 receptor 6D9H
TM5 199 5.60x60 μ receptor 5C1M μ receptor 5C1M
TM5 200 5.61x61 μ receptor 5C1M LPA6 receptor 5XSZ
TM5 201 5.62x62 μ receptor 5C1M AT2 receptor 5UNG
TM5 202 5.63x63 μ receptor 5C1M D2 receptor 6CM4
TM5 203 5.64x64 μ receptor 5C1M A1 receptor 6D9H
TM5 204 5.65x65 μ receptor 5C1M - -
TM5 205 5.66x66 μ receptor 5C1M - -
TM5 206 5.67x67 μ receptor 5C1M μ receptor 5C1M
TM5 207 5.68x68 μ receptor 5C1M C5a1 receptor 6C1R
ICL3 208 - - - -
ICL3 209 - - - -
ICL3 210 - - - -
TM6 211 6.30x30 μ receptor 5C1M μ receptor 5C1M
TM6 212 6.31x31 μ receptor 5C1M C5a1 receptor 6C1R
TM6 213 6.32x32 μ receptor 5C1M μ receptor 5C1M
TM6 214 6.33x33 μ receptor 5C1M CB1 receptor 5XRA
TM6 215 6.34x34 μ receptor 5C1M - -
TM6 216 6.35x35 μ receptor 5C1M - -
TM6 217 6.36x36 μ receptor 5C1M CB1 receptor 5XRA
TM6 218 6.37x37 μ receptor 5C1M LPA6 receptor 5XSZ
TM6 219 6.38x38 μ receptor 5C1M μ receptor 5C1M
TM6 220 6.39x39 μ receptor 5C1M CB1 receptor 5XRA
TM6 221 6.40x40 μ receptor 5C1M PAF receptor 5ZKP
TM6 222 6.41x41 μ receptor 5C1M μ receptor 5C1M
TM6 223 6.42x42 μ receptor 5C1M AT2 receptor 5UNG
TM6 224 6.43x43 μ receptor 5C1M μ receptor 5C1M
TM6 225 6.44x44 μ receptor 5C1M μ receptor 5C1M
TM6 226 6.45x45 μ receptor 5C1M 5-HT2C receptor 6BQG
TM6 227 6.46x46 μ receptor 5C1M A1 receptor 6D9H
TM6 228 6.47x47 μ receptor 5C1M μ receptor 5C1M
TM6 229 6.48x48 μ receptor 5C1M FFA1 receptor 5KW2
TM6 230 6.49x49 μ receptor 5C1M AT2 receptor 5UNG
TM6 231 6.50x50 μ receptor 5C1M μ receptor 5C1M
TM6 232 6.51x51 μ receptor 5C1M AT2 receptor 5UNG
TM6 233 6.52x52 μ receptor 5C1M - -
TM6 234 6.53x53 μ receptor 5C1M μ receptor 5C1M
TM6 235 6.54x54 μ receptor 5C1M AT2 receptor 5UNG
TM6 236 6.55x55 μ receptor 5C1M C5a1 receptor 5O9H
TM6 237 6.56x56 μ receptor 5C1M - -
TM6 238 6.57x57 μ receptor 5C1M AT2 receptor 5UNG
TM6 239 6.58x58 μ receptor 5C1M Rhodopsin 5DYS
TM6 240 6.59x59 μ receptor 5C1M PAR2 5NDD
TM6 241 6.60x60 μ receptor 5C1M P2Y1 receptor 4XNW
TM6 242 6.61x61 μ receptor 5C1M - -
ECL3 243 μ receptor 5C1M - -
ECL3 244 μ receptor 5C1M - -
ECL3 245 μ receptor 5C1M - -
ECL3 246 μ receptor 5C1M - -
TM7 247 7.28x27 μ receptor 5C1M - -
TM7 248 7.29x28 μ receptor 5C1M - -
TM7 249 7.30x29 μ receptor 5C1M CB1 receptor 5XRA
TM7 250 7.31x30 μ receptor 5C1M NTS1 receptor 5T04
TM7 251 7.32x31 μ receptor 5C1M - -
TM7 252 7.33x32 μ receptor 5C1M H1 receptor 3RZE
TM7 253 7.34x33 μ receptor 5C1M CB1 receptor 5XRA
TM7 254 7.35x34 μ receptor 5C1M κ receptor 6B73
TM7 255 7.36x35 μ receptor 5C1M PAR1 3VW7
TM7 256 7.37x36 μ receptor 5C1M 5-HT2C receptor 6BQG
TM7 257 7.38x37 μ receptor 5C1M μ receptor 5C1M
TM7 258 7.39x38 μ receptor 5C1M - -
TM7 259 7.40x39 μ receptor 5C1M US28 4XT1
TM7 260 7.41x40 μ receptor 5C1M μ receptor 5C1M
TM7 261 7.42x41 μ receptor 5C1M A2A receptor 5G53
TM7 262 7.43x42 μ receptor 5C1M PAF receptor 5ZKP
TM7 263 7.44x43 μ receptor 5C1M CB1 receptor 5XRA
TM7 264 7.45x45 μ receptor 5C1M μ receptor 5C1M
TM7 265 7.46x46 μ receptor 5C1M μ receptor 5C1M
TM7 266 7.47x47 μ receptor 5C1M κ receptor 6B73
TM7 267 7.48x48 μ receptor 5C1M ETB receptor 5X93
TM7 268 7.49x49 μ receptor 5C1M μ receptor 5C1M
TM7 269 7.50x50 μ receptor 5C1M μ receptor 5C1M
TM7 270 7.51x51 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 271 7.52x52 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 272 7.53x53 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 273 7.54x54 C5a1 receptor 5O9H P2Y1 receptor 4XNW
TM7 274 7.55x55 C5a1 receptor 5O9H AT2 receptor 5UNG
TM7 275 7.56x56 C5a1 receptor 5O9H AT2 receptor 5UNG
H8 276 8.47x47 PAR2 5NDD US28 4XT1
H8 277 8.48x48 PAR2 5NDD - -
H8 278 8.49x49 PAR2 5NDD - -
H8 279 8.50x50 PAR2 5NDD - -
H8 280 8.51x51 PAR2 5NDD AT2 receptor 5UNF
H8 281 8.52x52 PAR2 5NDD 5-HT2C receptor 6BQG
H8 282 8.53x53 PAR2 5NDD OX1 receptor 4ZJ8
H8 283 8.54x54 PAR2 5NDD - -
H8 284 8.55x55 PAR2 5NDD CB1 receptor 5XRA
H8 285 8.56x56 PAR2 5NDD LPA1 receptor 4Z36
H8 286 8.57x57 PAR2 5NDD - -
H8 287 8.58x58 PAR2 5NDD US28 4XT1
H8 288 8.59x59 US28 4XT1 CCR9 5LWE
H8 289 8.60x60 US28 4XT1 - -
H8 290 8.61x61 US28 4XT1 - -
C-term 291 - - - -
C-term 292 - - - -
C-term 293 - - - -
C-term 294 - - - -
C-term 295 - - - -