MC1 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 7.91 docs)

VERSION

2018-07-10

MAIN TEMPLATE

CB1 receptor (sequence similarity: 41%) PDB: 5XRA

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 81.9 7.6 10.4
Side-chains 23.6 50.3 26.0

Number of backbone templates: 7
Number of rotamer templates: 33

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5XRA
5TGZ
3V2Y
4XES
4PXZ
4DJH
4N6H
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 30 CB1 receptor 5XRA CB1 receptor 5XRA
N-term 31 CB1 receptor 5XRA CB1 receptor 5XRA
N-term 32 CB1 receptor 5XRA CB1 receptor 5XRA
N-term 33 CB1 receptor 5XRA CB1 receptor 5XRA
N-term 34 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 35 1.29x29 CB1 receptor 5XRA - -
TM1 36 1.30x30 CB1 receptor 5XRA PAR2 5NDD
TM1 37 1.31x31 CB1 receptor 5XRA M2 receptor 4MQT
TM1 38 1.32x32 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM1 39 1.33x33 CB1 receptor 5XRA A2A receptor 5G53
TM1 40 1.34x34 CB1 receptor 5XRA κ receptor 6B73
TM1 41 1.35x35 CB1 receptor 5XRA FFA1 receptor 5TZY
TM1 42 1.36x36 CB1 receptor 5XRA - -
TM1 43 1.37x37 CB1 receptor 5XRA A1 receptor 6D9H
TM1 44 1.38x38 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 45 1.39x39 CB1 receptor 5XRA LPA6 receptor 5XSZ
TM1 46 1.40x40 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 47 1.41x41 CB1 receptor 5XRA M2 receptor 4MQT
TM1 48 1.42x42 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 49 1.43x43 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 50 1.44x44 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM1 51 1.45x45 CB1 receptor 5XRA κ receptor 6B73
TM1 52 1.46x46 CB1 receptor 5XRA A1 receptor 6D9H
TM1 53 1.47x47 CB1 receptor 5XRA κ receptor 6B73
TM1 54 1.48x48 CB1 receptor 5XRA κ receptor 6B73
TM1 55 1.49x49 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 56 1.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 57 1.51x51 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM1 58 1.52x52 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 59 1.53x53 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 60 1.54x54 CB1 receptor 5XRA AT2 receptor 5UNG
TM1 61 1.55x55 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM1 62 1.56x56 CB1 receptor 5XRA NTS1 receptor 5T04
TM1 63 1.57x57 CB1 receptor 5XRA CB1 receptor 5XRA
TM1 64 1.58x58 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM1 65 1.59x59 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM1 66 1.60x60 CB1 receptor 5XRA - -
ICL1 67 12.48x48 - - - -
ICL1 68 12.49x49 S1P1 receptor 3V2Y A2A receptor 5G53
ICL1 69 12.50x50 S1P1 receptor 3V2Y 5-HT1B receptor 6G79
ICL1 70 12.51x51 - - - -
TM2 71 2.37x37 S1P1 receptor 3V2Y CXCR4 3ODU
TM2 72 2.38x38 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM2 73 2.39x39 S1P1 receptor 3V2Y S1P1 receptor 3V2Y
TM2 74 2.40x40 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 75 2.41x41 CB1 receptor 5XRA A1 receptor 6D9H
TM2 76 2.42x42 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 77 2.43x43 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 78 2.44x44 CB1 receptor 5XRA - -
TM2 79 2.45x45 CB1 receptor 5XRA - -
TM2 80 2.46x46 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 81 2.47x47 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 82 2.48x48 CB1 receptor 5XRA κ receptor 6B73
TM2 83 2.49x49 CB1 receptor 5XRA NTS1 receptor 5T04
TM2 84 2.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 85 2.51x51 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 86 2.52x52 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 87 2.53x53 CB1 receptor 5XRA κ receptor 6B73
TM2 88 2.54x54 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 89 2.55x55 CB1 receptor 5XRA - -
TM2 90 2.56x56 CB1 receptor 5XRA M2 receptor 4MQT
TM2 91 2.57x57 CB1 receptor 5XRA - -
TM2 92 2.58x58 CB1 receptor 5XRA CB1 receptor 5XRA
TM2 93 2.59x59 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM2 94 2.60x60 CB1 receptor 5XRA NTS1 receptor 5T04
TM2 95 2.61x61 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM2 96 2.62x62 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM2 97 2.63x63 CB1 receptor 5XRA κ receptor 6B73
TM2 98 2.64x64 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM2 99 2.65x65 CB1 receptor 5XRA κ receptor 6B73
TM2 100 2.66x66 CB1 receptor 5XRA NOP receptor 5DHG
TM2 101 2.67x67 NTS1 receptor 4XES - -
ECL1 102 - - - -
ECL1 103 - - - -
ECL1 104 - - - -
ECL1 105 - - - -
ECL1 106 - - - -
ECL1 107 - - - -
ECL1 108 - - - -
ECL1 109 - - - -
TM3 110 3.18x18 P2Y12 receptor 4PXZ - -
TM3 111 3.19x19 P2Y12 receptor 4PXZ - -
TM3 112 3.20x20 P2Y12 receptor 4PXZ - -
TM3 113 3.21x21 CB1 receptor 5XRA - -
TM3 114 3.22x22 CB1 receptor 5XRA 5-HT1B receptor 4IAQ
TM3 115 3.23x23 CB1 receptor 5XRA - -
TM3 116 3.24x24 CB1 receptor 5XRA κ receptor 6B73
TM3 117 3.25x25 CB1 receptor 5XRA - -
TM3 118 3.26x26 CB1 receptor 5XRA PAF receptor 5ZKP
TM3 119 3.27x27 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM3 120 3.28x28 CB1 receptor 5XRA A2A receptor 5G53
TM3 121 3.29x29 CB1 receptor 5XRA - -
TM3 122 3.30x30 CB1 receptor 5XRA CXCR4 3ODU
TM3 123 3.31x31 CB1 receptor 5XRA κ receptor 6B73
TM3 124 3.32x32 CB1 receptor 5XRA - -
TM3 125 3.33x33 CB1 receptor 5XRA Y1 receptor 5ZBH
TM3 126 3.34x34 CB1 receptor 5XRA - -
TM3 127 3.35x35 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 128 3.36x36 CB1 receptor 5XRA κ receptor 6B73
TM3 129 3.37x37 CB1 receptor 5XRA - -
TM3 130 3.38x38 CB1 receptor 5XRA A1 receptor 6D9H
TM3 131 3.39x39 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 132 3.40x40 CB1 receptor 5XRA US28 4XT1
TM3 133 3.41x41 CB1 receptor 5XRA US28 4XT1
TM3 134 3.42x42 CB1 receptor 5XRA LPA6 receptor 5XSZ
TM3 135 3.43x43 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 136 3.44x44 CB1 receptor 5XRA PAF receptor 5ZKP
TM3 137 3.45x45 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM3 138 3.46x46 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM3 139 3.47x47 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 140 3.48x48 CB1 receptor 5XRA κ receptor 6B73
TM3 141 3.49x49 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 142 3.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 143 3.51x51 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 144 3.52x52 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 145 3.53x53 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 146 3.54x54 CB1 receptor 5XRA CB1 receptor 5XRA
TM3 147 3.55x55 CB1 receptor 5XRA LPA1 receptor 4Z35
TM3 148 3.56x56 CB1 receptor 5XRA LPA6 receptor 5XSZ
ICL2 149 34.50x50 CB1 receptor 5XRA 5-HT1B receptor 6G79
ICL2 150 34.51x51 CB1 receptor 5XRA CB1 receptor 5XRA
ICL2 151 34.52x52 CB1 receptor 5XRA A1 receptor 6D9H
ICL2 152 34.53x53 CB1 receptor 5XRA CB1 receptor 5XRA
ICL2 153 34.54x54 CB1 receptor 5XRA CCR9 5LWE
ICL2 154 34.55x55 CB1 receptor 5XRA β2-adrenoceptor 3SN6
ICL2 155 34.56x56 CB1 receptor 5XRA CB1 receptor 5XRA
ICL2 156 34.57x57 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 157 4.38x38 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 158 4.39x39 CB1 receptor 5XRA CXCR4 3ODU
TM4 159 4.40x40 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 160 4.41x41 CB1 receptor 5XRA NTS1 receptor 5T04
TM4 161 4.42x42 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 162 4.43x43 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM4 163 4.44x44 CB1 receptor 5XRA - -
TM4 164 4.45x45 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 165 4.46x46 CB1 receptor 5XRA Rhodopsin 5DYS
TM4 166 4.47x47 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM4 167 4.48x48 CB1 receptor 5XRA NTS1 receptor 5T04
TM4 168 4.49x49 CB1 receptor 5XRA κ receptor 6B73
TM4 169 4.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 170 4.51x51 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM4 171 4.52x52 CB1 receptor 5XRA NTS1 receptor 5T04
TM4 172 4.53x53 CB1 receptor 5XRA κ receptor 6B73
TM4 173 4.54x54 CB1 receptor 5XRA US28 4XT1
TM4 174 4.55x55 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 175 4.56x56 CB1 receptor 5XRA - -
TM4 176 4.57x57 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM4 177 4.58x58 CB1 receptor 5XRA - -
TM4 178 4.59x59 CB1 receptor 5XRA CB1 receptor 5XRA
TM4 179 4.60x60 CB1 receptor 5XRA PAF receptor 5ZKP
TM4 180 4.61x61 CB1 receptor 5XRA κ receptor 6B73
TM4 181 4.62x62 CB1 receptor 5XRA Rhodopsin 4ZWJ
TM4 182 4.63x63 CB1 receptor 5XRA AT2 receptor 5UNG
ECL2 183 - - - -
ECL2 184 - - - -
ECL2 185 - - - -
ECL2 186 - - - -
ECL2 187 - - - -
ECL2 188 - - - -
ECL2 189 - - - -
ECL2 190 - - - -
ECL2 191 - - - -
TM5 192 5.33x33 κ receptor 4DJH P2Y1 receptor 4XNW
TM5 193 5.34x34 κ receptor 4DJH PAF receptor 5ZKQ
TM5 194 5.35x35 κ receptor 4DJH - -
TM5 195 5.36x36 CB1 receptor 5XRA 5-HT2B receptor 5TUD
TM5 196 5.37x37 CB1 receptor 5XRA P2Y1 receptor 4XNW
TM5 197 5.38x38 CB1 receptor 5XRA μ receptor 5C1M
TM5 198 5.39x39 CB1 receptor 5XRA FFA1 receptor 5TZY
TM5 199 5.40x40 CB1 receptor 5XRA A1 receptor 6D9H
TM5 200 5.41x41 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM5 201 5.42x42 CB1 receptor 5XRA NTS1 receptor 5T04
TM5 202 5.43x43 CB1 receptor 5XRA US28 4XT1
TM5 203 5.44x44 CB1 receptor 5XRA US28 4XT1
TM5 204 5.45x45 CB1 receptor 5XRA - -
TM5 205 5.46x46 CB1 receptor 5XRA CB1 receptor 5XRA
TM5 206 5.47x47 CB1 receptor 5XRA CXCR4 3ODU
TM5 207 5.48x48 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM5 208 5.49x49 CB1 receptor 5XRA CB1 receptor 5XRA
TM5 209 5.50x50 CB1 receptor 5XRA - -
TM5 210 5.51x51 CB1 receptor 5XRA NTS1 receptor 5T04
TM5 211 5.52x52 CB1 receptor 5XRA CB1 receptor 5XRA
TM5 212 5.53x53 CB1 receptor 5XRA - -
TM5 213 5.54x54 CB1 receptor 5XRA - -
TM5 214 5.55x55 CB1 receptor 5XRA AT2 receptor 5UNG
TM5 215 5.56x56 CB1 receptor 5XRA - -
TM5 216 5.57x57 CB1 receptor 5XRA - -
TM5 217 5.58x58 CB1 receptor 5XRA - -
TM5 218 5.59x59 CB1 receptor 5XRA LPA6 receptor 5XSZ
TM5 219 5.60x60 CB1 receptor 5XRA Rhodopsin 5DYS
TM5 220 5.61x61 CB1 receptor 5XRA - -
TM5 221 5.62x62 CB1 receptor 5XRA κ receptor 6B73
TM5 222 5.63x63 CB1 receptor 5XRA A1 receptor 5N2S
TM5 223 5.64x64 CB1 receptor 5XRA κ receptor 6B73
TM5 224 5.65x65 CB1 receptor 5XRA κ receptor 6B73
TM5 225 5.66x66 CB1 receptor 5XRA CB1 receptor 5XRA
TM5 226 5.67x67 CB1 receptor 5XRA A1 receptor 6D9H
ICL3 227 - - - -
ICL3 228 - - - -
ICL3 229 - - - -
ICL3 230 - - - -
ICL3 231 - - - -
ICL3 232 - - - -
TM6 233 6.27x27 CB1 receptor 5TGZ Rhodopsin 5DYS
TM6 234 6.28x28 CB1 receptor 5TGZ A1 receptor 6D9H
TM6 235 6.29x29 CB1 receptor 5TGZ - -
TM6 236 6.30x30 CB1 receptor 5XRA - -
TM6 237 6.31x31 CB1 receptor 5XRA A1 receptor 6D9H
TM6 238 6.32x32 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM6 239 6.33x33 CB1 receptor 5XRA NTS1 receptor 5T04
TM6 240 6.34x34 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 241 6.35x35 CB1 receptor 5XRA - -
TM6 242 6.36x36 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 243 6.37x37 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 244 6.38x38 CB1 receptor 5XRA - -
TM6 245 6.39x39 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM6 246 6.40x40 CB1 receptor 5XRA CXCR4 3ODU
TM6 247 6.41x41 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 248 6.42x42 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM6 249 6.43x43 CB1 receptor 5XRA LPA6 receptor 5XSZ
TM6 250 6.44x44 CB1 receptor 5XRA κ receptor 6B73
TM6 251 6.45x45 CB1 receptor 5XRA PAF receptor 5ZKP
TM6 252 6.46x46 CB1 receptor 5XRA β2-adrenoceptor 3SN6
TM6 253 6.47x47 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 254 6.48x48 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 255 6.49x49 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 256 6.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 257 6.51x51 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM6 258 6.52x52 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM6 259 6.53x53 CB1 receptor 5XRA US28 4XT1
TM6 260 6.54x54 CB1 receptor 5XRA - -
TM6 261 6.55x55 CB1 receptor 5XRA LPA6 receptor 5XSZ
TM6 262 6.56x56 CB1 receptor 5XRA P2Y1 receptor 4XNW
TM6 263 6.57x57 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM6 264 6.58x58 CB1 receptor 5XRA Rhodopsin 5DYS
TM6 265 6.59x59 CB1 receptor 5XRA CB1 receptor 5XRA
TM6 266 6.60x60 CB1 receptor 5XRA κ receptor 6B73
TM6 267 6.61x61 CB1 receptor 5XRA 5-HT2C receptor 6BQG
ECL3 268 - - - -
ECL3 269 δ receptor 4N6H - -
ECL3 270 δ receptor 4N6H - -
ECL3 271 δ receptor 4N6H - -
ECL3 272 - - - -
TM7 273 7.28x27 CB1 receptor 5XRA - -
TM7 274 7.29x28 CB1 receptor 5XRA - -
TM7 275 7.30x29 CB1 receptor 5XRA - -
TM7 276 7.31x30 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 277 7.32x31 CB1 receptor 5XRA P2Y12 receptor 4NTJ
TM7 278 7.33x32 CB1 receptor 5XRA 5-HT2C receptor 6BQH
TM7 279 7.34x33 CB1 receptor 5XRA - -
TM7 280 7.35x34 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 281 7.36x35 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM7 282 7.37x36 CB1 receptor 5XRA NTS1 receptor 5T04
TM7 283 7.38x37 CB1 receptor 5XRA 5-HT1B receptor 6G79
TM7 284 7.39x38 CB1 receptor 5XRA LPA6 receptor 5XSZ
TM7 285 7.40x39 CB1 receptor 5XRA κ receptor 6B73
TM7 286 7.41x40 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 287 7.42x41 CB1 receptor 5XRA - -
TM7 288 7.43x42 CB1 receptor 5XRA - -
TM7 289 7.44x43 CB1 receptor 5XRA US28 4XT1
TM7 290 7.45x45 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 291 7.46x46 CB1 receptor 5XRA Rhodopsin 5DYS
TM7 292 7.47x47 CB1 receptor 5XRA Rhodopsin 4ZWJ
TM7 293 7.48x48 CB1 receptor 5XRA NTS1 receptor 5T04
TM7 294 7.49x49 CB1 receptor 5XRA LPA6 receptor 5XSZ
TM7 295 7.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 296 7.51x51 CB1 receptor 5XRA 5-HT2C receptor 6BQG
TM7 297 7.52x52 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 298 7.53x53 CB1 receptor 5XRA CB1 receptor 5XRA
TM7 299 7.54x54 S1P1 receptor 3V2Y μ receptor 6DDF
TM7 300 7.55x55 S1P1 receptor 3V2Y A1 receptor 6D9H
TM7 301 7.56x56 S1P1 receptor 3V2Y - -
H8 302 8.47x47 CB1 receptor 5XRA CB1 receptor 5XRA
H8 303 8.48x48 CB1 receptor 5XRA A1 receptor 6D9H
H8 304 8.49x49 CB1 receptor 5XRA S1P1 receptor 3V2Y
H8 305 8.50x50 CB1 receptor 5XRA CB1 receptor 5XRA
H8 306 8.51x51 CB1 receptor 5XRA CB1 receptor 5XRA
H8 307 8.52x52 CB1 receptor 5XRA 5-HT2C receptor 6BQG
H8 308 8.53x53 CB1 receptor 5XRA A1 receptor 6D9H
H8 309 8.54x54 CB1 receptor 5XRA US28 4XT1
H8 310 8.55x55 CB1 receptor 5XRA M2 receptor 4MQT
H8 311 8.56x56 CB1 receptor 5XRA β2-adrenoceptor 3SN6
H8 312 8.57x57 CB1 receptor 5XRA AT2 receptor 5UNG
H8 313 8.58x58 CB1 receptor 5XRA Rhodopsin 6FKB
H8 314 8.59x59 κ receptor 4DJH 5-HT2B receptor 5TUD
C-term 315 - - - -
C-term 316 - - - -
C-term 317 - - - -