NK2 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate (Δ distance (Å): 7.21 docs)

VERSION

2018-07-10

MAIN TEMPLATE

μ receptor (sequence similarity: 42%) PDB: 6DDE

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 77.0 14.0 9.0
Side-chains 17.3 58.0 24.7

Number of backbone templates: 6
Number of rotamer templates: 41

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6DDE
4ZJ8
5WS3
3SN6
4UHR
5ZBH
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 28 - - - -
N-term 29 - - - -
N-term 30 - - - -
N-term 31 μ receptor 6DDE μ receptor 6DDE
N-term 32 μ receptor 6DDE μ receptor 6DDE
TM1 33 1.32x32 μ receptor 6DDE - -
TM1 34 1.33x33 μ receptor 6DDE D4 receptor 5WIV
TM1 35 1.34x34 μ receptor 6DDE NTS1 receptor 4XES
TM1 36 1.35x35 μ receptor 6DDE 5-HT2B receptor 4IB4
TM1 37 1.36x36 μ receptor 6DDE 5-HT2B receptor 4IB4
TM1 38 1.37x37 μ receptor 6DDE A2A receptor 4UHR
TM1 39 1.38x38 μ receptor 6DDE OX1 receptor 4ZJ8
TM1 40 1.39x39 μ receptor 6DDE μ receptor 6DDE
TM1 41 1.40x40 μ receptor 6DDE NTS1 receptor 4XES
TM1 42 1.41x41 μ receptor 6DDE NTS1 receptor 4XES
TM1 43 1.42x42 μ receptor 6DDE NTS1 receptor 4XES
TM1 44 1.43x43 μ receptor 6DDE β2-adrenoceptor 3SN6
TM1 45 1.44x44 μ receptor 6DDE 5-HT1B receptor 4IAQ
TM1 46 1.45x45 μ receptor 6DDE μ receptor 6DDE
TM1 47 1.46x46 μ receptor 6DDE A2A receptor 4UHR
TM1 48 1.47x47 μ receptor 6DDE PAF receptor 5ZKQ
TM1 49 1.48x48 μ receptor 6DDE apelin receptor 5VBL
TM1 50 1.49x49 μ receptor 6DDE μ receptor 6DDE
TM1 51 1.50x50 μ receptor 6DDE μ receptor 6DDE
TM1 52 1.51x51 μ receptor 6DDE 5-HT1B receptor 4IAQ
TM1 53 1.52x52 μ receptor 6DDE - -
TM1 54 1.53x53 μ receptor 6DDE μ receptor 6DDE
TM1 55 1.54x54 μ receptor 6DDE 5-HT2B receptor 4IB4
TM1 56 1.55x55 μ receptor 6DDE A2A receptor 4UHR
TM1 57 1.56x56 μ receptor 6DDE P2Y12 receptor 4NTJ
TM1 58 1.57x57 μ receptor 6DDE Y1 receptor 5ZBH
TM1 59 1.58x58 μ receptor 6DDE PAR2 5NDD
TM1 60 1.59x59 μ receptor 6DDE FFA1 receptor 5TZY
TM1 61 1.60x60 μ receptor 6DDE P2Y1 receptor 4XNW
ICL1 62 12.48x48 - - - -
ICL1 63 12.49x49 OX1 receptor 4ZJ8 β2-adrenoceptor 5JQH
ICL1 64 12.50x50 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
ICL1 65 12.51x51 - - - -
TM2 66 2.37x37 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
TM2 67 2.38x38 μ receptor 6DDE A2A receptor 4UHR
TM2 68 2.39x39 μ receptor 6DDE μ receptor 6DDE
TM2 69 2.40x40 μ receptor 6DDE A2A receptor 4UHR
TM2 70 2.41x41 μ receptor 6DDE NTS1 receptor 4XES
TM2 71 2.42x42 μ receptor 6DDE A2A receptor 4UHR
TM2 72 2.43x43 μ receptor 6DDE μ receptor 6DDE
TM2 73 2.44x44 μ receptor 6DDE A2A receptor 4UHR
TM2 74 2.45x45 μ receptor 6DDE μ receptor 6DDE
TM2 75 2.46x46 μ receptor 6DDE μ receptor 6DDE
TM2 76 2.47x47 μ receptor 6DDE μ receptor 6DDE
TM2 77 2.48x48 μ receptor 6DDE μ receptor 6DDE
TM2 78 2.49x49 μ receptor 6DDE μ receptor 6DDE
TM2 79 2.50x50 μ receptor 6DDE μ receptor 6DDE
TM2 80 2.51x51 μ receptor 6DDE NTS1 receptor 4XES
TM2 81 2.52x52 μ receptor 6DDE AT1 receptor 4ZUD
TM2 82 2.53x53 μ receptor 6DDE P2Y12 receptor 4NTJ
TM2 83 2.54x54 μ receptor 6DDE Y1 receptor 5ZBH
TM2 84 2.55x55 μ receptor 6DDE OX1 receptor 4ZJ8
TM2 85 2.56x56 μ receptor 6DDE - -
TM2 86 2.57x57 μ receptor 6DDE - -
TM2 87 2.58x58 μ receptor 6DDE - -
TM2 88 2.59x59 μ receptor 6DDE P2Y1 receptor 4XNW
TM2 89 2.60x60 μ receptor 6DDE D4 receptor 5WIV
TM2 90 2.61x61 μ receptor 6DDE - -
TM2 91 2.62x62 μ receptor 6DDE P2Y1 receptor 4XNW
TM2 92 2.63x63 μ receptor 6DDE OX1 receptor 4ZJ8
TM2 93 2.64x64 μ receptor 6DDE μ receptor 6DDE
TM2 94 2.65x65 μ receptor 6DDE P2Y12 receptor 4NTJ
TM2 95 2.66x66 μ receptor 6DDE PAR1 3VW7
TM2 96 2.67x67 OX2 receptor 5WS3 C5a1 receptor 5O9H
ECL1 97 - - - -
ECL1 98 23.49x49 OX2 receptor 5WS3 - -
ECL1 99 23.50x50 OX2 receptor 5WS3 OX2 receptor 5WS3
ECL1 100 23.51x51 OX2 receptor 5WS3 CXCR4 3ODU
ECL1 101 23.52x52 - - - -
TM3 102 3.21x21 μ receptor 6DDE μ receptor 6DDE
TM3 103 3.22x22 μ receptor 6DDE D3 receptor 3PBL
TM3 104 3.23x23 μ receptor 6DDE NTS1 receptor 4XES
TM3 105 3.24x24 μ receptor 6DDE apelin receptor 5VBL
TM3 106 3.25x25 μ receptor 6DDE μ receptor 6DDE
TM3 107 3.26x26 μ receptor 6DDE - -
TM3 108 3.27x27 μ receptor 6DDE A2A receptor 4UHR
TM3 109 3.28x28 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 110 3.29x29 μ receptor 6DDE CCR9 5LWE
TM3 111 3.30x30 μ receptor 6DDE - -
TM3 112 3.31x31 μ receptor 6DDE A2A receptor 4UHR
TM3 113 3.32x32 μ receptor 6DDE - -
TM3 114 3.33x33 μ receptor 6DDE 5-HT1B receptor 4IAQ
TM3 115 3.34x34 μ receptor 6DDE 5-HT1B receptor 4IAQ
TM3 116 3.35x35 μ receptor 6DDE H1 receptor 3RZE
TM3 117 3.36x36 μ receptor 6DDE μ receptor 6DDE
TM3 118 3.37x37 μ receptor 6DDE μ receptor 6DDE
TM3 119 3.38x38 μ receptor 6DDE OX1 receptor 4ZJ8
TM3 120 3.39x39 μ receptor 6DDE μ receptor 6DDE
TM3 121 3.40x40 μ receptor 6DDE μ receptor 6DDE
TM3 122 3.41x41 μ receptor 6DDE - -
TM3 123 3.42x42 μ receptor 6DDE A2A receptor 4UHR
TM3 124 3.43x43 μ receptor 6DDE PAR1 3VW7
TM3 125 3.44x44 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 126 3.45x45 μ receptor 6DDE A2A receptor 4UHR
TM3 127 3.46x46 μ receptor 6DDE A2A receptor 4UHR
TM3 128 3.47x47 μ receptor 6DDE A2A receptor 4UHR
TM3 129 3.48x48 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 130 3.49x49 μ receptor 6DDE μ receptor 6DDE
TM3 131 3.50x50 μ receptor 6DDE μ receptor 6DDE
TM3 132 3.51x51 μ receptor 6DDE μ receptor 6DDE
TM3 133 3.52x52 μ receptor 6DDE - -
TM3 134 3.53x53 μ receptor 6DDE μ receptor 6DDE
TM3 135 3.54x54 μ receptor 6DDE NTS1 receptor 4XES
TM3 136 3.55x55 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 137 3.56x56 μ receptor 6DDE μ receptor 6DDE
ICL2 138 - - - -
ICL2 139 OX1 receptor 4ZJ8 - -
ICL2 140 OX1 receptor 4ZJ8 - -
ICL2 141 OX1 receptor 4ZJ8 - -
ICL2 142 OX1 receptor 4ZJ8 - -
ICL2 143 - - - -
TM4 144 4.38x38 μ receptor 6DDE NTS1 receptor 4XES
TM4 145 4.39x39 μ receptor 6DDE PAR2 5NDD
TM4 146 4.40x40 μ receptor 6DDE CB1 receptor 5XRA
TM4 147 4.41x41 μ receptor 6DDE apelin receptor 5VBL
TM4 148 4.42x42 μ receptor 6DDE NTS1 receptor 4XES
TM4 149 4.43x43 μ receptor 6DDE μ receptor 6DDE
TM4 150 4.44x44 μ receptor 6DDE NOP receptor 5DHG
TM4 151 4.45x45 μ receptor 6DDE μ receptor 6DDE
TM4 152 4.46x46 μ receptor 6DDE NTS1 receptor 4XES
TM4 153 4.47x47 μ receptor 6DDE A2A receptor 4UHR
TM4 154 4.48x48 μ receptor 6DDE OX1 receptor 4ZJ8
TM4 155 4.49x49 μ receptor 6DDE NTS1 receptor 4XES
TM4 156 4.50x50 μ receptor 6DDE μ receptor 6DDE
TM4 157 4.51x51 μ receptor 6DDE NTS1 receptor 4XES
TM4 158 4.52x52 μ receptor 6DDE OX1 receptor 4ZJ8
TM4 159 4.53x53 μ receptor 6DDE PAR1 3VW7
TM4 160 4.54x54 μ receptor 6DDE PAR2 5NDD
TM4 161 4.55x55 μ receptor 6DDE μ receptor 6DDE
TM4 162 4.56x56 μ receptor 6DDE NTS1 receptor 4XES
TM4 163 4.57x57 OX1 receptor 4ZJ8 NTS1 receptor 4XES
TM4 164 4.58x59 OX1 receptor 4ZJ8 κ receptor 4DJH
TM4 165 4.59x60 μ receptor 6DDE NTS1 receptor 4XES
TM4 166 4.60x61 μ receptor 6DDE OX1 receptor 4ZJ8
TM4 167 4.61x62 μ receptor 6DDE - -
TM4 168 4.62x63 OX1 receptor 4ZJ8 NTS1 receptor 4XES
TM4 169 4.63x64 OX1 receptor 4ZJ8 Y1 receptor 5ZBH
TM4 170 4.64x65 OX1 receptor 4ZJ8 - -
ECL2 171 μ receptor 6DDE - -
ECL2 172 μ receptor 6DDE - -
ECL2 173 μ receptor 6DDE - -
ECL2 174 μ receptor 6DDE - -
ECL2 175 μ receptor 6DDE - -
ECL2 176 μ receptor 6DDE - -
ECL2 177 μ receptor 6DDE μ receptor 6DDE
ECL2 178 μ receptor 6DDE - -
ECL2 179 μ receptor 6DDE - -
ECL2 180 μ receptor 6DDE - -
ECL2 181 45.50x50 μ receptor 6DDE μ receptor 6DDE
ECL2 182 45.51x51 μ receptor 6DDE 5-HT2B receptor 4IB4
ECL2 183 45.52x52 μ receptor 6DDE 5-HT1B receptor 4IAQ
ECL2 184 - - - -
ECL2 185 - - - -
ECL2 186 - - - -
ECL2 187 - - - -
ECL2 188 - - - -
ECL2 189 - - - -
ECL2 190 - - - -
TM5 191 5.32x33 OX1 receptor 4ZJ8 - -
TM5 192 5.33x34 μ receptor 6DDE - -
TM5 193 5.34x35 μ receptor 6DDE NTS1 receptor 4XES
TM5 194 5.35x36 μ receptor 6DDE NTS1 receptor 4BUO
TM5 195 5.36x37 μ receptor 6DDE PAF receptor 5ZKQ
TM5 196 5.37x38 μ receptor 6DDE μ receptor 6DDE
TM5 197 5.38x39 μ receptor 6DDE A2A receptor 4UHR
TM5 198 5.39x40 μ receptor 6DDE PAF receptor 5ZKQ
TM5 199 5.40x41 μ receptor 6DDE 5-HT2B receptor 4IB4
TM5 200 5.41x42 μ receptor 6DDE NTS1 receptor 4XES
TM5 201 5.42x43 μ receptor 6DDE μ receptor 6DDE
TM5 202 5.43x44 μ receptor 6DDE CXCR4 3ODU
TM5 203 5.44x45 μ receptor 6DDE - -
TM5 204 5.45x46 μ receptor 6DDE FFA1 receptor 5TZY
TM5 205 5.46x461 μ receptor 6DDE - -
TM5 206 5.47x47 μ receptor 6DDE OX1 receptor 4ZJ8
TM5 207 5.48x48 μ receptor 6DDE 5-HT2B receptor 4IB4
TM5 208 5.49x49 μ receptor 6DDE PAF receptor 5ZKQ
TM5 209 5.50x50 μ receptor 6DDE μ receptor 6DDE
TM5 210 5.51x51 μ receptor 6DDE A2A receptor 4UHR
TM5 211 5.52x52 μ receptor 6DDE 5-HT2B receptor 4IB4
TM5 212 5.53x53 μ receptor 6DDE NTS1 receptor 4XES
TM5 213 5.54x54 μ receptor 6DDE A2A receptor 4UHR
TM5 214 5.55x55 μ receptor 6DDE Y1 receptor 5ZBH
TM5 215 5.56x56 μ receptor 6DDE μ receptor 6DDE
TM5 216 5.57x57 μ receptor 6DDE PAR2 5NDD
TM5 217 5.58x58 μ receptor 6DDE μ receptor 6DDE
TM5 218 5.59x59 μ receptor 6DDE β2-adrenoceptor 3SN6
TM5 219 5.60x60 μ receptor 6DDE NTS1 receptor 4XES
TM5 220 5.61x61 μ receptor 6DDE NTS1 receptor 4XES
TM5 221 5.62x62 μ receptor 6DDE - -
TM5 222 5.63x63 μ receptor 6DDE μ receptor 6DDE
TM5 223 5.64x64 μ receptor 6DDE PAF receptor 5ZKQ
TM5 224 5.65x65 μ receptor 6DDE μ receptor 6DDE
TM5 225 5.66x66 μ receptor 6DDE OX2 receptor 5WS3
TM5 226 5.67x67 μ receptor 6DDE A2A receptor 4UHR
TM5 227 5.68x68 μ receptor 6DDE C5a1 receptor 6C1R
TM5 228 5.69x69 β2-adrenoceptor 3SN6 5-HT2B receptor 4IB4
TM5 229 5.70x70 β2-adrenoceptor 3SN6 P2Y12 receptor 4NTJ
TM5 230 5.71x71 β2-adrenoceptor 3SN6 - -
TM5 231 5.72x72 β2-adrenoceptor 3SN6 - -
TM5 232 5.73x73 β2-adrenoceptor 3SN6 - -
ICL3 233 - - - -
ICL3 234 - - - -
ICL3 235 - - - -
ICL3 236 - - - -
TM6 237 6.22x22 A2A receptor 4UHR - -
TM6 238 6.23x23 μ receptor 6DDE - -
TM6 239 6.24x24 μ receptor 6DDE - -
TM6 240 6.25x25 μ receptor 6DDE LPA1 receptor 4Z35
TM6 241 6.26x26 μ receptor 6DDE ETB receptor 5X93
TM6 242 6.27x27 μ receptor 6DDE A2A receptor 4UHR
TM6 243 6.28x28 μ receptor 6DDE NTS1 receptor 4XEE
TM6 244 6.29x29 μ receptor 6DDE NTS1 receptor 4XES
TM6 245 6.30x30 μ receptor 6DDE LPA1 receptor 4Z35
TM6 246 6.31x31 μ receptor 6DDE PAR1 3VW7
TM6 247 6.32x32 μ receptor 6DDE 5-HT1B receptor 4IAR
TM6 248 6.33x33 μ receptor 6DDE - -
TM6 249 6.34x34 μ receptor 6DDE NTS1 receptor 4XES
TM6 250 6.35x35 μ receptor 6DDE A2A receptor 4UHR
TM6 251 6.36x36 μ receptor 6DDE 5-HT1B receptor 4IAQ
TM6 252 6.37x37 μ receptor 6DDE PAF receptor 5ZKQ
TM6 253 6.38x38 μ receptor 6DDE P2Y1 receptor 4XNW
TM6 254 6.39x39 μ receptor 6DDE A1 receptor 5UEN
TM6 255 6.40x40 μ receptor 6DDE μ receptor 6DDE
TM6 256 6.41x41 μ receptor 6DDE μ receptor 6DDE
TM6 257 6.42x42 μ receptor 6DDE P2Y1 receptor 4XNW
TM6 258 6.43x43 μ receptor 6DDE P2Y1 receptor 4XNW
TM6 259 6.44x44 μ receptor 6DDE μ receptor 6DDE
TM6 260 6.45x45 μ receptor 6DDE A2A receptor 4UHR
TM6 261 6.46x46 μ receptor 6DDE PAR1 3VW7
TM6 262 6.47x47 μ receptor 6DDE NTS1 receptor 4XES
TM6 263 6.48x48 μ receptor 6DDE μ receptor 6DDE
TM6 264 6.49x49 μ receptor 6DDE NTS1 receptor 4XES
TM6 265 6.50x50 μ receptor 6DDE μ receptor 6DDE
TM6 266 6.51x51 μ receptor 6DDE NTS1 receptor 4XES
TM6 267 6.52x52 μ receptor 6DDE μ receptor 6DDE
TM6 268 6.53x53 μ receptor 6DDE PAR2 5NDD
TM6 269 6.54x54 μ receptor 6DDE μ receptor 6DDE
TM6 270 6.55x55 μ receptor 6DDE H1 receptor 3RZE
TM6 271 6.56x56 μ receptor 6DDE μ receptor 6DDE
TM6 272 6.57x57 μ receptor 6DDE OX1 receptor 4ZJ8
TM6 273 6.58x58 μ receptor 6DDE - -
TM6 274 6.59x59 μ receptor 6DDE CXCR4 3ODU
TM6 275 6.60x60 μ receptor 6DDE A2A receptor 4UHR
TM6 276 6.61x61 μ receptor 6DDE β2-adrenoceptor 2RH1
ECL3 277 - - - -
ECL3 278 Y1 receptor 5ZBH - -
ECL3 279 Y1 receptor 5ZBH Y1 receptor 5ZBH
ECL3 280 Y1 receptor 5ZBH - -
ECL3 281 - - - -
TM7 282 7.28x27 OX1 receptor 4ZJ8 PAF receptor 5ZKQ
TM7 283 7.29x28 OX1 receptor 4ZJ8 5-HT2C receptor 6BQH
TM7 284 7.30x29 μ receptor 6DDE NTS1 receptor 4XES
TM7 285 7.31x30 μ receptor 6DDE PAF receptor 5ZKQ
TM7 286 7.32x31 μ receptor 6DDE 5-HT2B receptor 4IB4
TM7 287 7.33x32 μ receptor 6DDE CCR5 5UIW
TM7 288 7.34x33 μ receptor 6DDE P2Y12 receptor 4NTJ
TM7 289 7.35x34 μ receptor 6DDE NTS1 receptor 4XES
TM7 290 7.36x35 μ receptor 6DDE PAR1 3VW7
TM7 291 7.37x36 μ receptor 6DDE D3 receptor 3PBL
TM7 292 7.38x37 μ receptor 6DDE β2-adrenoceptor 3SN6
TM7 293 7.39x38 μ receptor 6DDE - -
TM7 294 7.40x39 μ receptor 6DDE 5-HT2B receptor 4IB4
TM7 295 7.41x40 μ receptor 6DDE μ receptor 6DDE
TM7 296 7.42x41 μ receptor 6DDE NTS1 receptor 4GRV
TM7 297 7.43x42 μ receptor 6DDE Y1 receptor 5ZBH
TM7 298 7.44x43 μ receptor 6DDE LPA6 receptor 5XSZ
TM7 299 7.45x45 μ receptor 6DDE NTS1 receptor 4XES
TM7 300 7.46x46 μ receptor 6DDE Y1 receptor 5ZBH
TM7 301 7.47x47 μ receptor 6DDE - -
TM7 302 7.48x48 μ receptor 6DDE Rhodopsin 5DYS
TM7 303 7.49x49 μ receptor 6DDE μ receptor 6DDE
TM7 304 7.50x50 μ receptor 6DDE μ receptor 6DDE
TM7 305 7.51x51 μ receptor 6DDE P2Y1 receptor 4XNW
TM7 306 7.52x52 μ receptor 6DDE A2A receptor 4UHR
TM7 307 7.53x53 μ receptor 6DDE μ receptor 6DDE
TM7 308 7.54x54 μ receptor 6DDE PAF receptor 5ZKQ
TM7 309 7.55x55 OX1 receptor 4ZJ8 - -
TM7 310 7.56x56 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
H8 311 8.47x47 OX1 receptor 4ZJ8 5-HT2B receptor 4IB4
H8 312 8.48x48 OX1 receptor 4ZJ8 PAR2 5NDD
H8 313 8.49x49 OX1 receptor 4ZJ8 apelin receptor 5VBL
H8 314 8.50x50 OX1 receptor 4ZJ8 A2A receptor 4UHR
H8 315 8.51x51 OX1 receptor 4ZJ8 A2A receptor 4UHR
H8 316 8.52x52 OX1 receptor 4ZJ8 - -
H8 317 8.53x53 OX1 receptor 4ZJ8 - -
H8 318 8.54x54 OX1 receptor 4ZJ8 A2A receptor 4UHR
H8 319 8.55x55 OX1 receptor 4ZJ8 A2A receptor 4UHR
H8 320 8.56x56 OX1 receptor 4ZJ8 M1 receptor 5CXV
H8 321 8.57x57 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
H8 322 8.58x58 OX1 receptor 4ZJ8 OX1 receptor 4ZJ8
C-term 323 - - - -
C-term 324 - - - -
C-term 325 - - - -
C-term 326 - - - -
C-term 327 - - - -