NK3 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 9.66 docs)

VERSION

2018-07-10

MAIN TEMPLATE

κ receptor (sequence similarity: 46%) PDB: 6B73

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 75.5 16.1 8.4
Side-chains 20.5 54.4 25.2

Number of backbone templates: 7
Number of rotamer templates: 41

NGL is a WebGL based 3D viewer powered by MMTF.

6B73
5WS3
5UIW
5UNF
3SN6
4UHR
5ZBH
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 79 - - - -
N-term 80 - - - -
N-term 81 κ receptor 6B73 κ receptor 6B73
N-term 82 κ receptor 6B73 κ receptor 6B73
N-term 83 κ receptor 6B73 κ receptor 6B73
TM1 84 1.31x31 κ receptor 6B73 PAF receptor 5ZKP
TM1 85 1.32x32 κ receptor 6B73 Y1 receptor 5ZBH
TM1 86 1.33x33 κ receptor 6B73 A1 receptor 6D9H
TM1 87 1.34x34 κ receptor 6B73 LPA6 receptor 5XSZ
TM1 88 1.35x35 κ receptor 6B73 5-HT2B receptor 4IB4
TM1 89 1.36x36 κ receptor 6B73 LPA6 receptor 5XSZ
TM1 90 1.37x37 κ receptor 6B73 M2 receptor 4MQT
TM1 91 1.38x38 κ receptor 6B73 OX1 receptor 4ZJ8
TM1 92 1.39x39 κ receptor 6B73 κ receptor 6B73
TM1 93 1.40x40 κ receptor 6B73 US28 4XT1
TM1 94 1.41x41 κ receptor 6B73 κ receptor 6B73
TM1 95 1.42x42 κ receptor 6B73 κ receptor 6B73
TM1 96 1.43x43 κ receptor 6B73 β2-adrenoceptor 3SN6
TM1 97 1.44x44 κ receptor 6B73 δ receptor 4N6H
TM1 98 1.45x45 κ receptor 6B73 κ receptor 6B73
TM1 99 1.46x46 κ receptor 6B73 A2A receptor 5G53
TM1 100 1.47x47 κ receptor 6B73 β2-adrenoceptor 3SN6
TM1 101 1.48x48 κ receptor 6B73 AT2 receptor 5UNG
TM1 102 1.49x49 κ receptor 6B73 κ receptor 6B73
TM1 103 1.50x50 κ receptor 6B73 κ receptor 6B73
TM1 104 1.51x51 κ receptor 6B73 CB1 receptor 5XRA
TM1 105 1.52x52 κ receptor 6B73 - -
TM1 106 1.53x53 κ receptor 6B73 κ receptor 6B73
TM1 107 1.54x54 κ receptor 6B73 β2-adrenoceptor 3SN6
TM1 108 1.55x55 κ receptor 6B73 A2A receptor 5G53
TM1 109 1.56x56 κ receptor 6B73 LPA6 receptor 5XSZ
TM1 110 1.57x57 κ receptor 6B73 κ receptor 6B73
TM1 111 1.58x58 κ receptor 6B73 CB1 receptor 5XRA
TM1 112 1.59x59 κ receptor 6B73 FFA1 receptor 5TZY
TM1 113 1.60x60 κ receptor 6B73 NOP receptor 5DHG
ICL1 114 12.48x48 - - - -
ICL1 115 12.49x49 OX2 receptor 5WS3 β2-adrenoceptor 4LDE
ICL1 116 12.50x50 OX2 receptor 5WS3 OX2 receptor 5WS3
ICL1 117 12.51x51 - - - -
TM2 118 2.37x37 κ receptor 6B73 κ receptor 6B73
TM2 119 2.38x38 κ receptor 6B73 β2-adrenoceptor 3SN6
TM2 120 2.39x39 κ receptor 6B73 κ receptor 6B73
TM2 121 2.40x40 κ receptor 6B73 κ receptor 6B73
TM2 122 2.41x41 κ receptor 6B73 β2-adrenoceptor 3SN6
TM2 123 2.42x42 κ receptor 6B73 β2-adrenoceptor 3SN6
TM2 124 2.43x43 κ receptor 6B73 Rhodopsin 5DYS
TM2 125 2.44x44 κ receptor 6B73 A2A receptor 5G53
TM2 126 2.45x45 κ receptor 6B73 κ receptor 6B73
TM2 127 2.46x46 κ receptor 6B73 κ receptor 6B73
TM2 128 2.47x47 κ receptor 6B73 κ receptor 6B73
TM2 129 2.48x48 κ receptor 6B73 Y1 receptor 5ZBH
TM2 130 2.49x49 κ receptor 6B73 LPA6 receptor 5XSZ
TM2 131 2.50x50 κ receptor 6B73 κ receptor 6B73
TM2 132 2.51x51 κ receptor 6B73 κ receptor 6B73
TM2 133 2.52x52 κ receptor 6B73 - -
TM2 134 2.53x53 κ receptor 6B73 β2-adrenoceptor 3SN6
TM2 135 2.54x54 κ receptor 6B73 Y1 receptor 5ZBH
TM2 136 2.55x55 κ receptor 6B73 AT2 receptor 5UNG
TM2 137 2.56x56 κ receptor 6B73 - -
TM2 138 2.57x57 κ receptor 6B73 - -
TM2 139 2.58x58 κ receptor 6B73 Rhodopsin 5DYS
TM2 140 2.59x59 κ receptor 6B73 LPA6 receptor 5XSZ
TM2 141 2.60x60 κ receptor 6B73 D2 receptor 6CM4
TM2 142 2.61x61 κ receptor 6B73 - -
TM2 143 2.62x62 κ receptor 6B73 LPA6 receptor 5XSZ
TM2 144 2.63x63 κ receptor 6B73 A2A receptor 5G53
TM2 145 2.64x64 κ receptor 6B73 κ receptor 6B73
TM2 146 2.65x65 κ receptor 6B73 AT1 receptor 4ZUD
TM2 147 2.66x66 κ receptor 6B73 NOP receptor 5DHG
TM2 148 2.67x67 κ receptor 6B73 κ receptor 6B73
TM2 149 2.68x68 - - - -
ECL1 150 23.49x49 - - - -
ECL1 151 23.50x50 - - - -
ECL1 152 23.51x51 - - - -
ECL1 153 23.52x52 - - - -
TM3 154 3.21x21 κ receptor 6B73 κ receptor 6B73
TM3 155 3.22x22 κ receptor 6B73 ETB receptor 5X93
TM3 156 3.23x23 κ receptor 6B73 CB1 receptor 5XRA
TM3 157 3.24x24 κ receptor 6B73 - -
TM3 158 3.25x25 κ receptor 6B73 κ receptor 6B73
TM3 159 3.26x26 κ receptor 6B73 NTS1 receptor 5T04
TM3 160 3.27x27 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 161 3.28x28 κ receptor 6B73 Rhodopsin 4ZWJ
TM3 162 3.29x29 κ receptor 6B73 CCR9 5LWE
TM3 163 3.30x30 κ receptor 6B73 Rhodopsin 5DYS
TM3 164 3.31x31 κ receptor 6B73 Rhodopsin 5DYS
TM3 165 3.32x32 κ receptor 6B73 - -
TM3 166 3.33x33 κ receptor 6B73 5-HT1B receptor 6G79
TM3 167 3.34x34 κ receptor 6B73 LPA6 receptor 5XSZ
TM3 168 3.35x35 κ receptor 6B73 US28 4XT1
TM3 169 3.36x36 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 170 3.37x37 κ receptor 6B73 κ receptor 6B73
TM3 171 3.38x38 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 172 3.39x39 κ receptor 6B73 κ receptor 6B73
TM3 173 3.40x40 κ receptor 6B73 κ receptor 6B73
TM3 174 3.41x41 κ receptor 6B73 - -
TM3 175 3.42x42 κ receptor 6B73 Rhodopsin 5DYS
TM3 176 3.43x43 κ receptor 6B73 PAR1 3VW7
TM3 177 3.44x44 κ receptor 6B73 κ receptor 6B73
TM3 178 3.45x45 κ receptor 6B73 5-HT2C receptor 6BQG
TM3 179 3.46x46 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 180 3.47x47 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 181 3.48x48 κ receptor 6B73 κ receptor 6B73
TM3 182 3.49x49 κ receptor 6B73 κ receptor 6B73
TM3 183 3.50x50 κ receptor 6B73 κ receptor 6B73
TM3 184 3.51x51 κ receptor 6B73 κ receptor 6B73
TM3 185 3.52x52 κ receptor 6B73 - -
TM3 186 3.53x53 κ receptor 6B73 κ receptor 6B73
TM3 187 3.54x54 κ receptor 6B73 β2-adrenoceptor 3SN6
TM3 188 3.55x55 κ receptor 6B73 AT2 receptor 5UNG
TM3 189 3.56x56 κ receptor 6B73 5-HT1B receptor 4IAQ
ICL2 190 - - - -
ICL2 191 OX2 receptor 5WS3 OX2 receptor 5WS3
ICL2 192 OX2 receptor 5WS3 - -
ICL2 193 OX2 receptor 5WS3 - -
ICL2 194 OX2 receptor 5WS3 - -
ICL2 195 - - - -
TM4 196 4.38x38 κ receptor 6B73 NTS1 receptor 5T04
TM4 197 4.39x39 κ receptor 6B73 OX2 receptor 5WS3
TM4 198 4.40x40 κ receptor 6B73 5-HT2C receptor 6BQG
TM4 199 4.41x41 κ receptor 6B73 BLT1 receptor 5X33
TM4 200 4.42x42 κ receptor 6B73 NTS1 receptor 5T04
TM4 201 4.43x43 κ receptor 6B73 κ receptor 6B73
TM4 202 4.44x44 κ receptor 6B73 κ receptor 6B73
TM4 203 4.45x45 κ receptor 6B73 μ receptor 5C1M
TM4 204 4.46x46 κ receptor 6B73 β2-adrenoceptor 3SN6
TM4 205 4.47x47 κ receptor 6B73 D4 receptor 5WIV
TM4 206 4.48x48 κ receptor 6B73 - -
TM4 207 4.49x49 κ receptor 6B73 κ receptor 6B73
TM4 208 4.50x50 κ receptor 6B73 κ receptor 6B73
TM4 209 4.51x51 κ receptor 6B73 μ receptor 5C1M
TM4 210 4.52x52 κ receptor 6B73 κ receptor 6B73
TM4 211 4.53x53 κ receptor 6B73 Rhodopsin 5DYS
TM4 212 4.54x54 κ receptor 6B73 A2A receptor 5G53
TM4 213 4.55x55 κ receptor 6B73 β2-adrenoceptor 3SN6
TM4 214 4.56x56 κ receptor 6B73 NTS1 receptor 5T04
TM4 215 4.57x57 OX2 receptor 5WS3 Rhodopsin 5DYS
TM4 216 4.58x59 OX2 receptor 5WS3 - -
TM4 217 4.59x60 κ receptor 6B73 β2-adrenoceptor 3SN6
TM4 218 4.60x61 κ receptor 6B73 OX2 receptor 5WS3
TM4 219 4.61x62 κ receptor 6B73 - -
TM4 220 4.62x63 κ receptor 6B73 κ receptor 6B73
TM4 221 4.63x64 κ receptor 6B73 - -
TM4 222 4.64x65 OX2 receptor 5WS3 - -
ECL2 223 - - - -
ECL2 224 CCR5 5UIW - -
ECL2 225 CCR5 5UIW - -
ECL2 226 CCR5 5UIW - -
ECL2 227 CCR5 5UIW - -
ECL2 228 CCR5 5UIW - -
ECL2 229 CCR5 5UIW - -
ECL2 230 CCR5 5UIW - -
ECL2 231 CCR5 5UIW - -
ECL2 232 - - - -
ECL2 233 45.50x50 κ receptor 6B73 κ receptor 6B73
ECL2 234 45.51x51 κ receptor 6B73 Y1 receptor 5ZBH
ECL2 235 45.52x52 κ receptor 6B73 5-HT1B receptor 6G79
ECL2 236 - - - -
ECL2 237 AT2 receptor 5UNF - -
ECL2 238 AT2 receptor 5UNF AT2 receptor 5UNF
ECL2 239 AT2 receptor 5UNF - -
ECL2 240 AT2 receptor 5UNF - -
ECL2 241 - - - -
TM5 242 5.33x34 κ receptor 6B73 - -
TM5 243 5.34x35 κ receptor 6B73 - -
TM5 244 5.35x36 κ receptor 6B73 P2Y12 receptor 4NTJ
TM5 245 5.36x37 κ receptor 6B73 PAR2 5NDD
TM5 246 5.37x38 κ receptor 6B73 CB1 receptor 5XRA
TM5 247 5.38x39 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 248 5.39x40 κ receptor 6B73 PAF receptor 5ZKP
TM5 249 5.40x41 κ receptor 6B73 κ receptor 6B73
TM5 250 5.41x42 κ receptor 6B73 5-HT2C receptor 6BQG
TM5 251 5.42x43 κ receptor 6B73 κ receptor 6B73
TM5 252 5.43x44 κ receptor 6B73 CB1 receptor 5XRA
TM5 253 5.44x45 κ receptor 6B73 κ receptor 6B73
TM5 254 5.45x46 κ receptor 6B73 AT2 receptor 5UNG
TM5 255 5.46x461 κ receptor 6B73 PAR2 5NDD
TM5 256 5.47x47 κ receptor 6B73 OX2 receptor 5WS3
TM5 257 5.48x48 κ receptor 6B73 ETB receptor 5X93
TM5 258 5.49x49 κ receptor 6B73 NTS1 receptor 5T04
TM5 259 5.50x50 κ receptor 6B73 κ receptor 6B73
TM5 260 5.51x51 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 261 5.52x52 κ receptor 6B73 κ receptor 6B73
TM5 262 5.53x53 κ receptor 6B73 κ receptor 6B73
TM5 263 5.54x54 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 264 5.55x55 κ receptor 6B73 - -
TM5 265 5.56x56 κ receptor 6B73 NTS1 receptor 5T04
TM5 266 5.57x57 κ receptor 6B73 5-HT2C receptor 6BQG
TM5 267 5.58x58 κ receptor 6B73 κ receptor 6B73
TM5 268 5.59x59 κ receptor 6B73 κ receptor 6B73
TM5 269 5.60x60 κ receptor 6B73 CXCR4 3ODU
TM5 270 5.61x61 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 271 5.62x62 κ receptor 6B73 - -
TM5 272 5.63x63 κ receptor 6B73 Y1 receptor 5ZBH
TM5 273 5.64x64 κ receptor 6B73 LPA6 receptor 5XSZ
TM5 274 5.65x65 κ receptor 6B73 κ receptor 6B73
TM5 275 5.66x66 κ receptor 6B73 OX2 receptor 5WS3
TM5 276 5.67x67 κ receptor 6B73 - -
TM5 277 5.68x68 β2-adrenoceptor 3SN6 - -
TM5 278 5.69x69 β2-adrenoceptor 3SN6 - -
TM5 279 5.70x70 β2-adrenoceptor 3SN6 - -
TM5 280 5.71x71 β2-adrenoceptor 3SN6 - -
TM5 281 5.72x72 β2-adrenoceptor 3SN6 - -
TM5 282 5.73x73 β2-adrenoceptor 3SN6 β2-adrenoceptor 3SN6
ICL3 283 - - - -
ICL3 284 - - - -
ICL3 285 - - - -
TM6 286 6.22x22 A2A receptor 4UHR - -
TM6 287 6.23x23 κ receptor 6B73 - -
TM6 288 6.24x24 κ receptor 6B73 - -
TM6 289 6.25x25 κ receptor 6B73 μ receptor 6DDF
TM6 290 6.26x26 κ receptor 6B73 OX2 receptor 5WS3
TM6 291 6.27x27 κ receptor 6B73 A2A receptor 5G53
TM6 292 6.28x28 κ receptor 6B73 Rhodopsin 5DYS
TM6 293 6.29x29 κ receptor 6B73 Rhodopsin 5DYS
TM6 294 6.30x30 κ receptor 6B73 LPA6 receptor 5XSZ
TM6 295 6.31x31 κ receptor 6B73 μ receptor 5C1M
TM6 296 6.32x32 κ receptor 6B73 β2-adrenoceptor 3P0G
TM6 297 6.33x33 κ receptor 6B73 Rhodopsin 5DYS
TM6 298 6.34x34 κ receptor 6B73 NTS1 receptor 5T04
TM6 299 6.35x35 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 300 6.36x36 κ receptor 6B73 μ receptor 5C1M
TM6 301 6.37x37 κ receptor 6B73 PAF receptor 5ZKP
TM6 302 6.38x38 κ receptor 6B73 LPA6 receptor 5XSZ
TM6 303 6.39x39 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 304 6.40x40 κ receptor 6B73 κ receptor 6B73
TM6 305 6.41x41 κ receptor 6B73 κ receptor 6B73
TM6 306 6.42x42 κ receptor 6B73 - -
TM6 307 6.43x43 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 308 6.44x44 κ receptor 6B73 κ receptor 6B73
TM6 309 6.45x45 κ receptor 6B73 A2A receptor 5G53
TM6 310 6.46x46 κ receptor 6B73 Rhodopsin 5DYS
TM6 311 6.47x47 κ receptor 6B73 κ receptor 6B73
TM6 312 6.48x48 κ receptor 6B73 κ receptor 6B73
TM6 313 6.49x49 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 314 6.50x50 κ receptor 6B73 κ receptor 6B73
TM6 315 6.51x51 κ receptor 6B73 LPA6 receptor 5XSZ
TM6 316 6.52x52 κ receptor 6B73 κ receptor 6B73
TM6 317 6.53x53 κ receptor 6B73 κ receptor 6B73
TM6 318 6.54x54 κ receptor 6B73 μ receptor 5C1M
TM6 319 6.55x55 κ receptor 6B73 H1 receptor 3RZE
TM6 320 6.56x56 κ receptor 6B73 μ receptor 5C1M
TM6 321 6.57x57 κ receptor 6B73 5-HT2C receptor 6BQG
TM6 322 6.58x58 κ receptor 6B73 A2A receptor 5G53
TM6 323 6.59x59 κ receptor 6B73 κ receptor 6B73
TM6 324 6.60x60 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 325 6.61x61 κ receptor 6B73 FFA1 receptor 5TZY
ECL3 326 - - - -
ECL3 327 Y1 receptor 5ZBH Y1 receptor 5ZBH
ECL3 328 Y1 receptor 5ZBH - -
ECL3 329 Y1 receptor 5ZBH - -
ECL3 330 - - - -
TM7 331 7.28x27 κ receptor 6B73 - -
TM7 332 7.29x28 κ receptor 6B73 CB1 receptor 5XRA
TM7 333 7.30x29 κ receptor 6B73 - -
TM7 334 7.31x30 κ receptor 6B73 AT2 receptor 5UNG
TM7 335 7.32x31 κ receptor 6B73 5-HT2B receptor 5TUD
TM7 336 7.33x32 κ receptor 6B73 CCR5 5UIW
TM7 337 7.34x33 κ receptor 6B73 β2-adrenoceptor 3SN6
TM7 338 7.35x34 κ receptor 6B73 κ receptor 6B73
TM7 339 7.36x35 κ receptor 6B73 Y1 receptor 5ZBH
TM7 340 7.37x36 κ receptor 6B73 D2 receptor 6CM4
TM7 341 7.38x37 κ receptor 6B73 OX2 receptor 5WS3
TM7 342 7.39x38 κ receptor 6B73 - -
TM7 343 7.40x39 κ receptor 6B73 β2-adrenoceptor 3SN6
TM7 344 7.41x40 κ receptor 6B73 κ receptor 6B73
TM7 345 7.42x41 κ receptor 6B73 LPA6 receptor 5XSZ
TM7 346 7.43x42 κ receptor 6B73 Y1 receptor 5ZBH
TM7 347 7.44x43 κ receptor 6B73 LPA6 receptor 5XSZ
TM7 348 7.45x45 κ receptor 6B73 Rhodopsin 5DYS
TM7 349 7.46x46 κ receptor 6B73 Y1 receptor 5ZBH
TM7 350 7.47x47 κ receptor 6B73 - -
TM7 351 7.48x48 κ receptor 6B73 Rhodopsin 5DYS
TM7 352 7.49x49 κ receptor 6B73 κ receptor 6B73
TM7 353 7.50x50 κ receptor 6B73 κ receptor 6B73
TM7 354 7.51x51 κ receptor 6B73 LPA6 receptor 5XSZ
TM7 355 7.52x52 OX2 receptor 5WS3 OX2 receptor 5WS3
TM7 356 7.53x53 OX2 receptor 5WS3 OX2 receptor 5WS3
TM7 357 7.54x54 OX2 receptor 5WS3 β2-adrenoceptor 3SN6
TM7 358 7.55x55 OX2 receptor 5WS3 - -
TM7 359 7.56x56 OX2 receptor 5WS3 OX2 receptor 5WS3
H8 360 8.47x47 OX2 receptor 5WS3 Rhodopsin 5DYS
H8 361 8.48x48 OX2 receptor 5WS3 Rhodopsin 5DYS
H8 362 8.49x49 OX2 receptor 5WS3 AT2 receptor 5UNG
H8 363 8.50x50 OX2 receptor 5WS3 OX2 receptor 5WS3
H8 364 8.51x51 OX2 receptor 5WS3 OX2 receptor 5WS3
H8 365 8.52x52 OX2 receptor 5WS3 NOP receptor 5DHG
H8 366 8.53x53 OX2 receptor 5WS3 - -
H8 367 8.54x54 OX2 receptor 5WS3 β2-adrenoceptor 3SN6
H8 368 8.55x55 OX2 receptor 5WS3 M2 receptor 4MQT
H8 369 8.56x56 OX2 receptor 5WS3 5-HT2B receptor 5TUD
H8 370 8.57x57 OX2 receptor 5WS3 OX2 receptor 5WS3
H8 371 8.58x58 OX2 receptor 5WS3 OX2 receptor 5WS3
C-term 372 - - - -
C-term 373 - - - -
C-term 374 - - - -
C-term 375 - - - -
C-term 376 - - - -