SELECT A RECEPTOR in the table and click a green button

The next page shows plots for the ligand bias rank order ΔΔLog(Emax/EC50) by transducer or effector family across publications.
Physiology-bias, pathway-bias and benchmark-bias is explained in the article Community Guidelines for GPCR Ligand Bias

  Receptor classification Number of ligands


Class
 
Ligand type
 
Family
 
Species
 
Receptor
(UniProt)
Receptor
(GtP)
Tested
(total)
Balanced
references
Physiology
biased
Pathway
biased
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT1A 5-HT1A 24 1 23 -
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT1B 5-HT1B 12 - 9 -
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT2A 5-HT2A 11 - - -
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT2B 5-HT2B 20 1 10 1
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT2C 5-HT2C 32 2 22 6
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT7R 5-HT7 6 - - -
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM1 M1 14 - 2 -
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM2 M2 22 - 6 -
A Aminergic Dopamine Homo sapiens DRD2 D2 319 3 54 19
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM3 M3 8 - 2 -
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM4 M4 5 - - -
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM5 M5 5 3 1 -
A Aminergic Adrenoceptors Homo sapiens ADA1A α1A-adrenoceptor 8 - 6 -
A Aminergic Adrenoceptors Homo sapiens ADA2C α2C-adrenoceptor 8 - 7 -
A Aminergic Adrenoceptors Homo sapiens ADRB1 β1-adrenoceptor 25 1 6 -
A Aminergic Adrenoceptors Homo sapiens ADRB2 β2-adrenoceptor 67 2 45 -
A Aminergic Dopamine Homo sapiens DRD1 D1 129 2 21 -
A Aminergic Dopamine Homo sapiens DRD3 D3 28 - - -
A Aminergic Dopamine Homo sapiens DRD5 D5 6 - 5 -
A Aminergic Histamine Homo sapiens HRH3 H3 5 - 1 -
A Aminergic Histamine Homo sapiens HRH4 H4 31 - 14 -
A Peptide Angiotensin Homo sapiens AGTR1 AT1 27 3 23 4
A Peptide Apelin Homo sapiens APJ apelin 54 2 8 6
A Peptide Complement peptide Homo sapiens C5AR1 C5a1 2 - - -
A Peptide Endothelin Homo sapiens EDNRA ETA 4 - 3 -
A Peptide Formylpeptide Homo sapiens FPR1 FPR1 13 - 8 -
A Peptide Formylpeptide Homo sapiens FPR2 FPR2/ALX 6 - 1 -
A Peptide Galanin Homo sapiens GALR2 GAL2 3 - 2 -
A Peptide Ghrelin Homo sapiens GHSR ghrelin 17 - 1 -
A Peptide Melanocortin Homo sapiens MSHR MC1 4 - - -
A Peptide Melanocortin Homo sapiens MC3R MC3 4 - - -
A Peptide Melanocortin Homo sapiens MC4R MC4 4 3 1 -
A Peptide Melanocortin Homo sapiens MC5R MC5 4 - - -
A Peptide Neuropeptide S Homo sapiens NPSR1 NPS 6 - - -
A Peptide Neuropeptide Y Homo sapiens NPY1R Y1 4 - - -
A Protein Chemokine Homo sapiens CXCR1 CXCR1 3 - 2 -
A Peptide Opioid Homo sapiens OPRD δ 82 3 17 29
A Peptide Opioid Homo sapiens OPRK κ 123 3 52 4
A Peptide Opioid Homo sapiens OPRM μ 310 6 51 9
A Peptide Opioid Homo sapiens OPRX NOP 28 - 21 -
A Peptide Proteinase-activated Homo sapiens PAR2 PAR2 2 - - -
A Peptide Relaxin family peptide Homo sapiens RXFP1 RXFP1 2 - - -
A Protein Chemokine Homo sapiens CXCR2 CXCR2 6 - 5 -
A Peptide Vasopressin and oxytocin Homo sapiens V1AR V1A 2 - 1 -
A Peptide Vasopressin and oxytocin Homo sapiens V1BR V1B 2 - - -
A Peptide Vasopressin and oxytocin Homo sapiens V2R V2 2 - 1 -
A Peptide Vasopressin and oxytocin Homo sapiens OXYR OT 2 - 1 -
A Protein Chemokine Homo sapiens CCR1 CCR1 11 3 7 4
A Protein Chemokine Homo sapiens CCR2 CCR2 3 - 2 -
A Protein Chemokine Homo sapiens CCR5 CCR5 7 - 6 -
A Protein Chemokine Homo sapiens CCR10 CCR10 2 - 1 -
A Protein Chemokine Homo sapiens CXCR3 CXCR3 33 2 4 1
A Protein Chemokine Homo sapiens CXCR4 CXCR4 2 - 1 -
A Protein Glycoprotein hormone Homo sapiens LSHR LH 4 - 2 -
A Lipid Free fatty acid Homo sapiens FFAR1 FFA1 9 - 7 -
A Lipid Lysophospholipid (LPA) Homo sapiens LPAR1 LPA1 10 - - -
A Lipid Lysophospholipid (S1P) Homo sapiens S1PR1 S1P1 2 1 1 -
A Lipid Cannabinoid Homo sapiens CNR1 CB1 48 2 8 21
A Lipid Cannabinoid Homo sapiens CNR2 CB2 46 2 34 5
A Lipid Prostanoid Homo sapiens PE2R2 EP2 39 - 7 -
A Lipid Prostanoid Homo sapiens PE2R4 EP4 11 - 10 -
A Nucleotide Adenosine Homo sapiens AA1R A1 31 - 2 -
A Nucleotide Adenosine Homo sapiens AA2BR A2B 11 - 9 -
A Nucleotide Adenosine Homo sapiens AA3R A3 55 3 22 41
A Orphan A orphans Homo sapiens GPR84 GPR84 77 28 2 -
B1 Peptide Calcitonin Homo sapiens CALCR CT 8 1 3 -
B1 Peptide Calcitonin Homo sapiens CALRL calcitonin -like 19 1 1 -
B1 Peptide Glucagon Homo sapiens GLP1R GLP-1 60 1 4 1
B1 Peptide Glucagon Homo sapiens GLR glucagon 1 - - -
A Lipid Cannabinoid Mus musculus CNR2 CB2 39 20 1 -
A Aminergic 5-Hydroxytryptamine Rattus norvegicus 5HT2A 5-HT2A 11 1 10 10
A Peptide Opioid Rattus norvegicus OPRD δ 16 - 1 -
A Peptide Opioid Rattus norvegicus OPRM μ 24 - 18 -
A Peptide Opioid Mus musculus OPRD δ 42 - - -
B1 Peptide Glucagon Mus musculus GLP1R GLP-1 7 - - -
A Aminergic Dopamine Mus musculus DRD2 D2 21 - - -
A Peptide Opioid Mus musculus OPRK κ 43 - 12 -
A Nucleotide Adenosine Mus musculus AA2BR A2B 8 - - -
C Ion Calcium-sensing Rattus norvegicus CASR CaS 10 1 1 -
B1 Peptide Glucagon Rattus norvegicus GLP1R GLP-1 17 - - -
A Peptide Opioid Mus musculus OPRM μ 43 - - -
A Peptide Opioid Canis lupus familiaris A0A0F6TMT6 μ 1 - - -