SELECT A RECEPTOR in the table and click a green button

The next page shows plots for the ligand bias rank order ΔΔLog(Emax/EC50) by transducer or effector family across publications.
Physiology-bias, pathway-bias and benchmark-bias is explained in the article Community Guidelines for GPCR Ligand Bias.
*Biased ligands have a bias factor ≥ 5.

  Receptor classification Number of ligands


Class
 
Ligand type
 
Family
 
Species
 
Receptor
(UniProt)
Receptor
(GtP)
Tested
(total)
Balanced
references
Pathway
biased *
Physiology
biased *
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT1A 5-HT1A 24 - - -
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT1B 5-HT1B 12 - - -
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT2A 5-HT2A 11 - - -
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT2B 5-HT2B 20 - - -
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT2C 5-HT2C 32 - - -
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT7R 5-HT7 6 - - -
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM1 M1 14 - - -
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM2 M2 22 - - -
A Aminergic Dopamine Homo sapiens DRD2 D2 319 2 7 7
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM3 M3 8 - - -
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM4 M4 5 - - -
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM5 M5 5 - - -
A Aminergic Adrenoceptors Homo sapiens ADA1A α1A-adrenoceptor 8 - - -
A Aminergic Adrenoceptors Homo sapiens ADA2C α2C-adrenoceptor 8 - - 2
A Aminergic Adrenoceptors Homo sapiens ADRB1 β1-adrenoceptor 25 - - -
A Aminergic Adrenoceptors Homo sapiens ADRB2 β2-adrenoceptor 67 - - -
A Aminergic Dopamine Homo sapiens DRD1 D1 129 1 - 1
A Aminergic Dopamine Homo sapiens DRD3 D3 28 1 - 1
A Aminergic Dopamine Homo sapiens DRD5 D5 6 - - -
A Aminergic Histamine Homo sapiens HRH3 H3 5 - - -
A Aminergic Histamine Homo sapiens HRH4 H4 31 - - -
A Peptide Angiotensin Homo sapiens AGTR1 AT1 27 - - -
A Peptide Apelin Homo sapiens APJ apelin 54 1 - 1
A Peptide Complement peptide Homo sapiens C5AR1 C5a1 2 - - -
A Peptide Endothelin Homo sapiens EDNRA ETA 4 - - -
A Peptide Formylpeptide Homo sapiens FPR1 FPR1 13 - - -
A Peptide Formylpeptide Homo sapiens FPR2 FPR2/ALX 6 - - -
A Peptide Galanin Homo sapiens GALR2 GAL2 3 - - -
A Peptide Ghrelin Homo sapiens GHSR ghrelin 17 1 - -
A Peptide Melanocortin Homo sapiens MSHR MC1 4 - - -
A Peptide Melanocortin Homo sapiens MC3R MC3 4 - - -
A Peptide Melanocortin Homo sapiens MC4R MC4 4 - - -
A Peptide Melanocortin Homo sapiens MC5R MC5 4 - - -
A Peptide Neuropeptide S Homo sapiens NPSR1 NPS 6 - - -
A Peptide Neuropeptide Y Homo sapiens NPY1R Y1 4 - - -
A Peptide Opioid Homo sapiens OPRD δ 82 1 - -
A Peptide Opioid Homo sapiens OPRK κ 123 - - -
A Peptide Opioid Homo sapiens OPRM μ 310 8 1 3
A Peptide Opioid Homo sapiens OPRX NOP 28 - - 1
A Peptide Proteinase-activated Homo sapiens PAR2 PAR2 2 - - -
A Peptide Relaxin family peptide Homo sapiens RXFP1 RXFP1 2 - - -
A Peptide Vasopressin and oxytocin Homo sapiens V1AR V1A 2 - - -
A Peptide Vasopressin and oxytocin Homo sapiens V1BR V1B 2 - - -
A Peptide Vasopressin and oxytocin Homo sapiens V2R V2 2 - - -
A Peptide Vasopressin and oxytocin Homo sapiens OXYR OT 2 - - -
A Protein Chemokine Homo sapiens CCR1 CCR1 11 1 - -
A Protein Chemokine Homo sapiens CCR2 CCR2 3 - - -
A Protein Chemokine Homo sapiens CCR5 CCR5 7 1 - -
A Protein Chemokine Homo sapiens CCR10 CCR10 2 - - -
A Protein Chemokine Homo sapiens CXCR1 CXCR1 3 - - -
A Protein Chemokine Homo sapiens CXCR2 CXCR2 6 - - -
A Protein Chemokine Homo sapiens CXCR3 CXCR3 33 1 - -
A Protein Chemokine Homo sapiens CXCR4 CXCR4 2 - - -
A Protein Glycoprotein hormone Homo sapiens LSHR LH 4 - - -
A Lipid Free fatty acid Homo sapiens FFAR1 FFA1 9 1 - -
A Lipid Lysophospholipid (LPA) Homo sapiens LPAR1 LPA1 10 - - -
A Lipid Lysophospholipid (S1P) Homo sapiens S1PR1 S1P1 2 - - -
A Lipid Cannabinoid Homo sapiens CNR1 CB1 48 2 - -
A Lipid Cannabinoid Homo sapiens CNR2 CB2 46 1 - 8
A Lipid Prostanoid Homo sapiens PE2R2 EP2 39 - - -
A Lipid Prostanoid Homo sapiens PE2R4 EP4 11 - - -
A Nucleotide Adenosine Homo sapiens AA1R A1 34 - - -
A Nucleotide Adenosine Homo sapiens AA2BR A2B 11 - - -
A Nucleotide Adenosine Homo sapiens AA3R A3 55 1 - -
A Orphan A orphans Homo sapiens GPR84 GPR84 77 - - -
B1 Peptide Calcitonin Homo sapiens CALCR CT 8 - - -
B1 Peptide Calcitonin Homo sapiens CALRL calcitonin -like 19 - - -
B1 Peptide Glucagon Homo sapiens GLP1R GLP-1 60 - - -
B1 Peptide Glucagon Homo sapiens GLR glucagon 1 - - -
A Aminergic 5-Hydroxytryptamine Rattus norvegicus 5HT2A 5-HT2A 11 - - -
A Peptide Opioid Mus musculus OPRD δ 42 - - -
A Peptide Opioid Rattus norvegicus OPRD δ 16 - - -
B1 Peptide Glucagon Mus musculus GLP1R GLP-1 7 - - -
A Peptide Opioid Rattus norvegicus OPRM μ 24 - - 1
A Aminergic Dopamine Mus musculus DRD2 D2 21 - - -
A Peptide Opioid Mus musculus OPRK κ 43 - - -
A Nucleotide Adenosine Mus musculus AA2BR A2B 8 - - -
C Ion Calcium-sensing Rattus norvegicus CASR CaS 10 - - -
B1 Peptide Glucagon Rattus norvegicus GLP1R GLP-1 17 - - -
A Peptide Opioid Mus musculus OPRM μ 43 - - -
A Peptide Opioid Canis lupus familiaris A0A0F6TMT6 μ 1 - - -