Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Unit Assay Type Assay Description Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles
CHEMBL199824 5ht1a_human Human Yes 11.0 EC50 = 0.0 Funct
Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulationAgonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulation
423 7 0 6 3.0 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC=CC4=C3C=C(C=C4)OC
CHEMBL199824 5ht1a_human Human Yes 11.0 EC50 = 0.0 Funct
Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulationAgonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulation
423 7 0 6 3.0 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC=CC4=C3C=C(C=C4)OC
CHEMBL1290716 5ht1a_human Human No 10.5 EC50 = 0.0 Funct
Agonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
413 4 0 4 4.1 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C=CC(=O)N(C5=CC=C4)C
CHEMBL1290716 5ht1a_human Human No 10.5 EC50 = 0.0 Funct
Agonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
413 4 0 4 4.1 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C=CC(=O)N(C5=CC=C4)C
CHEMBL199824 5ht1a_human Human Yes 10.3 EC50 = 0.1 Funct
Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S bindingAgonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S binding
423 7 0 6 3.0 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC=CC4=C3C=C(C=C4)OC
CHEMBL199824 5ht1a_human Human Yes 10.3 EC50 = 0.1 Funct
Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S bindingAgonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S binding
423 7 0 6 3.0 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC=CC4=C3C=C(C=C4)OC
CHEMBL3330612 5ht1a_human Human No 10.1 EC50 = 0.1 Funct
Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry
344 6 0 6 1.1 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC=CC=N3
CHEMBL3330612 5ht1a_human Human No 10.1 EC50 = 0.1 Funct
Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry
344 6 0 6 1.1 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC=CC=N3
CHEMBL2413154 5ht1a_human Human Yes 10.0 EC50 = 0.1 Funct
Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry
373 7 0 6 1.8 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL2413154 5ht1a_human Human Yes 10.0 EC50 = 0.1 Funct
Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry
373 7 0 6 1.8 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL2413154 5ht1a_human Human Yes 10.0 EC50 = 0.1 Funct
Partial agonist activity at human 5HT1A receptor expressed in CHO cells assessed as increase in [35S]GTPgammaS bindingPartial agonist activity at human 5HT1A receptor expressed in CHO cells assessed as increase in [35S]GTPgammaS binding
373 7 0 6 1.8 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL439849 5ht1a_human Human Yes 9.9 EC50 = 0.1 Funct
Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay
442 7 2 5 4.0 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
CHEMBL276031 5ht1a_human Human Yes 9.9 EC50 = 0.1 Funct
EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor
298 6 1 2 3.9 CCCN(CCC)C1CC2=CNC3=C2C(=C(C=C3)C(=O)C)C1
CHEMBL3330616 5ht1a_human Human No 9.7 EC50 = 0.2 Funct
Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry
362 6 0 7 1.5 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=NC(=CC=C3)F
CHEMBL3330616 5ht1a_human Human No 9.7 EC50 = 0.2 Funct
Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry
362 6 0 7 1.5 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=NC(=CC=C3)F
CHEMBL426317 5ht1a_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cellsAgonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cells
373 7 0 6 1.8 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC(=CC=C3)OC
CHEMBL3330603 5ht1a_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry
343 6 0 5 1.8 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC=CC=C3
CHEMBL426317 5ht1a_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cellsAgonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cells
373 7 0 6 1.8 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC(=CC=C3)OC
CHEMBL3330603 5ht1a_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry
343 6 0 5 1.8 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC=CC=C3
CHEMBL2112778 5ht1a_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayAgonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assay
351 4 0 4 4.1 COC1=CC=CC(=C1)C2CCC(CC2)N3CCN(CC3)C4=CC=CC=N4
CHEMBL511857 5ht1a_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayAgonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assay
351 4 0 4 4.1 COC1=CC=CC(=C1)C2CCC(CC2)N3CCN(CC3)C4=CC=CC=N4
CHEMBL521350 5ht1a_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayAgonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assay
351 4 0 4 4.1 COC1=CC=CC(=C1)C2CCC(CC2)N3CCN(CC3)C4=CC=CC=N4
CHEMBL2112778 5ht1a_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayAgonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assay
351 4 0 4 4.1 COC1=CC=CC(=C1)C2CCC(CC2)N3CCN(CC3)C4=CC=CC=N4
CHEMBL511857 5ht1a_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayAgonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assay
351 4 0 4 4.1 COC1=CC=CC(=C1)C2CCC(CC2)N3CCN(CC3)C4=CC=CC=N4
CHEMBL521350 5ht1a_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayAgonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assay
351 4 0 4 4.1 COC1=CC=CC(=C1)C2CCC(CC2)N3CCN(CC3)C4=CC=CC=N4
CHEMBL127171 5ht1a_human Human No 9.5 EC50 = 0.3 Funct
Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
360 9 2 5 4.1 COC1=C(C=C(C=C1)F)OCCNCCCC2=CNC3=C2C=C(C=C3)F
CHEMBL2413153 5ht1a_human Human No 9.2 EC50 = 0.7 Funct
Partial agonist activity at human 5HT1A receptor expressed in CHO cells assessed as increase in [35S]GTPgammaS bindingPartial agonist activity at human 5HT1A receptor expressed in CHO cells assessed as increase in [35S]GTPgammaS binding
405 9 0 7 2.1 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC=CC=C3OCCF
CHEMBL46539 5ht1a_human Human No 9.1 EC50 = 0.7 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
446 6 2 6 2.8 C1CN(CCC1(CNCC2=CC=CC(=N2)C3=CC=NN3)F)C(=O)C4=CC(=C(C=C4)F)Cl
CHEMBL444590 5ht1a_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA
366 6 0 4 4.7 COC1=CC=CC2=C1CCCC2CCCN3CCN(CC3)C4=CC=CC=N4
CHEMBL444590 5ht1a_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA
366 6 0 4 4.7 COC1=CC=CC2=C1CCCC2CCCN3CCN(CC3)C4=CC=CC=N4
CHEMBL316960 5ht1a_human Human No 9.1 EC50 = 0.8 Funct
In vitro potency at human 5-hydroxytryptamine 1A receptor in inhibiting forskolin-stimulated accumulation of intracellular cAMPIn vitro potency at human 5-hydroxytryptamine 1A receptor in inhibiting forskolin-stimulated accumulation of intracellular cAMP
413 5 1 6 3.5 CC1CN(CC(N1CCNC(=O)C2=CC=C(C=C2)F)C)C3=C4C(=CC=C3)OCCO4
CHEMBL81728 5ht1a_human Human No 9.1 EC50 = 0.8 Funct
In vitro potency at human 5-hydroxytryptamine 1A receptor in inhibiting forskolin-stimulated accumulation of intracellular cAMPIn vitro potency at human 5-hydroxytryptamine 1A receptor in inhibiting forskolin-stimulated accumulation of intracellular cAMP
385 5 1 6 2.6 C1CN(CCN1CCNC(=O)C2=CC=C(C=C2)F)C3=C4C(=CC=C3)OCCO4
CHEMBL2112778 5ht1a_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA
351 4 0 4 4.1 COC1=CC=CC(=C1)C2CCC(CC2)N3CCN(CC3)C4=CC=CC=N4
CHEMBL511857 5ht1a_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA
351 4 0 4 4.1 COC1=CC=CC(=C1)C2CCC(CC2)N3CCN(CC3)C4=CC=CC=N4
CHEMBL521350 5ht1a_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA
351 4 0 4 4.1 COC1=CC=CC(=C1)C2CCC(CC2)N3CCN(CC3)C4=CC=CC=N4
CHEMBL2112778 5ht1a_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA
351 4 0 4 4.1 COC1=CC=CC(=C1)C2CCC(CC2)N3CCN(CC3)C4=CC=CC=N4
CHEMBL511857 5ht1a_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA
351 4 0 4 4.1 COC1=CC=CC(=C1)C2CCC(CC2)N3CCN(CC3)C4=CC=CC=N4
CHEMBL521350 5ht1a_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA
351 4 0 4 4.1 COC1=CC=CC(=C1)C2CCC(CC2)N3CCN(CC3)C4=CC=CC=N4
CHEMBL3330614 5ht1a_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry
362 6 0 7 1.2 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=C(C=CC=N3)F
CHEMBL3330614 5ht1a_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry
362 6 0 7 1.2 CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=C(C=CC=N3)F
CHEMBL81728 5ht1a_human Human No 9.1 EC50 = 0.9 Funct
Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)
385 5 1 6 2.6 C1CN(CCN1CCNC(=O)C2=CC=C(C=C2)F)C3=C4C(=CC=C3)OCCO4
CHEMBL142862 5ht1a_human Human No 9.0 EC50 = 0.9 Funct
EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor
236 4 1 3 2.4 CN(C)CCC1=CNC2=C1C(=C(C=C2)OC)F
CHEMBL81728 5ht1a_human Human No 9.0 EC50 = 1.0 Funct
Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)
385 5 1 6 2.6 C1CN(CCN1CCNC(=O)C2=CC=C(C=C2)F)C3=C4C(=CC=C3)OCCO4
CHEMBL419240 5ht1a_human Human No 9.0 EC50 = 1.1 Funct
Effective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cellsEffective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cells
370 8 2 5 3.7 C1COC2=C(O1)C=CC=C2OCCNCCCC3=CNC4=C3C=C(C=C4)F
CHEMBL327126 5ht1a_human Human No 9.0 EC50 = 1.1 Funct
Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsStimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells
407 5 1 5 3.9 C1CN(CCC12C3=C(CO2)C4=CC=CC=C4C=C3)CC(COC5=CC=CC=C5F)O
CHEMBL46582 5ht1a_human Human No 9.0 EC50 = 1.1 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
462 6 2 5 3.4 C1CN(CCC1(CNCC2=CC=CC(=N2)C3=CC=NN3)F)C(=O)C4=CC(=C(C=C4)Cl)Cl
CHEMBL326751 5ht1a_human Human No 8.9 EC50 = 1.2 Funct
Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsStimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells
389 5 1 4 3.8 C1CN(CCC12C3=C(CO2)C4=CC=CC=C4C=C3)CC(COC5=CC=CC=C5)O
CHEMBL139505 5ht1a_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA
361 6 0 4 4.7 COC1=CC=CC2=C1C=CC=C2CCCN3CCN(CC3)C4=CC=CC=N4
CHEMBL139505 5ht1a_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA
361 6 0 4 4.7 COC1=CC=CC2=C1C=CC=C2CCCN3CCN(CC3)C4=CC=CC=N4
CHEMBL2112645 5ht1a_human Human No 8.9 EC50 = 1.3 Funct
Effective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cellsEffective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cells
324 9 2 3 3.9 COC1=CC=CC=C1OCCNCCCC2=CNC3=CC=CC=C32
CHEMBL311015 5ht1a_human Human No 8.9 EC50 = 1.3 Funct
Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)
421 6 0 6 3.0 C1CN(CCN1CCCCN2C(=O)C3=CC=CC=C3C2=O)C4=C5C(=CC=C4)OCCO5
CHEMBL330827 5ht1a_human Human No 8.9 EC50 = 1.4 Funct
Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
352 8 3 4 3.6 C1=CC2=C(C(=C1)OCCNCCCC3=CNC4=C3C=C(C=C4)F)N=CN2
CHEMBL1926761 5ht1a_human Human No 8.8 EC50 = 1.5 Funct
Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA
400 7 1 5 3.0 C1CC2=CC=CC=C2OC1CNCCCCN3C(=O)C4=CC=CC=C4S3(=O)=O
CHEMBL1926761 5ht1a_human Human No 8.8 EC50 = 1.5 Funct
Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA
400 7 1 5 3.0 C1CC2=CC=CC=C2OC1CNCCCCN3C(=O)C4=CC=CC=C4S3(=O)=O
CHEMBL79161 5ht1a_human Human No 8.8 EC50 = 1.6 Funct
Ability to influence the binding of [35S]GTP-gamma-S, to HeLa cell membranes expressing the human 5-hydroxytryptamine 1A receptorAbility to influence the binding of [35S]GTP-gamma-S, to HeLa cell membranes expressing the human 5-hydroxytryptamine 1A receptor
414 8 1 7 2.4 CC1=NN(C(=O)C(=C1C(=O)C)NCCCN2CCN(CC2)C3=CC=CC=C3OC)C
CHEMBL331609 5ht1a_human Human No 8.8 EC50 = 1.6 Funct
Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
334 8 3 3 3.5 C1=CC=C2C(=C1)C(=CN2)CCCNCCOC3=CC=CC4=C3N=CN4
CHEMBL2112882 5ht1a_human Human No 8.7 EC50 = 2.0 Funct
Binding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-SBinding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-S
598 6 4 6 3.0 CC(C)CC1C(=O)NC(C2(N1C(=O)C(O2)(C)NC(=O)C3CN(C4CC5=CNC6=CC=CC(=C56)C4=C3)C)O)CC7=CC=CC=C7
CHEMBL297138 5ht1a_human Human No 8.7 EC50 = 2.0 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
445 6 1 5 3.5 C1CN(CCC1CNCC2=CC=CC(=N2)C3=CN=CO3)C(=O)C4=CC(=C(C=C4)Cl)Cl
CHEMBL231471 5ht1a_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
447 6 1 7 3.0 C1CN(CCC1(CNCC2=NC=CC(=N2)C3=CC=CO3)F)C(=O)C4=CC(=C(C=C4)F)Cl
CHEMBL595055 5ht1a_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
440 6 2 5 4.3 CCN(CCCC1=CNC2=C1C=C(C=C2)F)C3CC4=C5C(=CC(=C4OC3)F)CCNC5=O
CHEMBL218261 5ht1a_human Human Yes 8.0 EC50 = 10 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
364 7 1 3 4.8 CC1(CC2=C(O1)C(=CC=C2)OCCNCC3=CC=CC(=C3)C4=CCCC4)C
CHEMBL1259241 5ht1a_human Human No 8.0 EC50 = 10 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
398 5 1 5 3.5 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CSC4=CC=CC=C43)F
CHEMBL231471 5ht1a_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
447 6 1 7 3.0 C1CN(CCC1(CNCC2=NC=CC(=N2)C3=CC=CO3)F)C(=O)C4=CC(=C(C=C4)F)Cl
CHEMBL595055 5ht1a_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
440 6 2 5 4.3 CCN(CCCC1=CNC2=C1C=C(C=C2)F)C3CC4=C5C(=CC(=C4OC3)F)CCNC5=O
CHEMBL218261 5ht1a_human Human Yes 8.0 EC50 = 10 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
364 7 1 3 4.8 CC1(CC2=C(O1)C(=CC=C2)OCCNCC3=CC=CC(=C3)C4=CCCC4)C
CHEMBL42766 5ht1a_human Human No 8.0 EC50 = 10 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
405 6 1 5 3.2 CN(C)C1=CC=CC(=N1)CNCC2(CCN(CC2)C(=O)C3=CC(=CC=C3)Cl)F
CHEMBL1259241 5ht1a_human Human No 8.0 EC50 = 10 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
398 5 1 5 3.5 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CSC4=CC=CC=C43)F
CHEMBL45423 5ht1a_human Human No 8.0 EC50 = 10.7 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
451 6 1 5 4.0 C1CN(C1)C2=CC=CC(=N2)CNCC3(CCN(CC3)C(=O)C4=CC(=C(C=C4)Cl)Cl)F
CHEMBL56 5ht1a_human Human Yes 8.0 EC50 = 10.9 Funct
In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsIn vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL56 5ht1a_human Human Yes 8.0 EC50 = 10.9 Funct
In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsIn vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL1259055 5ht1a_human Human No 7.0 EC50 = 100 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
380 5 2 4 2.6 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC4=C(C=C3)NC=C4)F
CHEMBL1259055 5ht1a_human Human No 7.0 EC50 = 100 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
380 5 2 4 2.6 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC4=C(C=C3)NC=C4)F
CHEMBL592939 5ht1a_human Human No 7.0 EC50 = 101 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
466 7 2 5 4.7 C1CC1CN(CCCC2=CNC3=C2C=C(C=C3)F)C4CC5=C6C(=CC(=C5OC4)F)CCNC6=O
CHEMBL3805772 5ht1a_human Human No 7.0 EC50 = 101 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
450 9 1 4 5.1 CCNC(=O)C1=CC(=CC=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
CHEMBL592939 5ht1a_human Human No 7.0 EC50 = 101 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
466 7 2 5 4.7 C1CC1CN(CCCC2=CNC3=C2C=C(C=C3)F)C4CC5=C6C(=CC(=C5OC4)F)CCNC6=O
CHEMBL3805772 5ht1a_human Human No 7.0 EC50 = 101 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
450 9 1 4 5.1 CCNC(=O)C1=CC(=CC=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
CHEMBL1774384 5ht1a_human Human No 6.0 EC50 = 1080 Funct
Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding
501 8 1 5 5.4 C1CN(CCN1CC(CCNC(=O)C2=CC=C(C=C2)C3=CC=CC=N3)F)C4=C(C(=CC=C4)Cl)Cl
CHEMBL1774384 5ht1a_human Human No 6.0 EC50 = 1080 Funct
Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding
501 8 1 5 5.4 C1CN(CCN1CC(CCNC(=O)C2=CC=C(C=C2)C3=CC=CC=N3)F)C4=C(C(=CC=C4)Cl)Cl
CHEMBL1259209 5ht1a_human Human No 8.0 EC50 = 11 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
400 5 1 4 3.4 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C34CC5CC(C3)CC(C5)C4)F
CHEMBL1259209 5ht1a_human Human No 8.0 EC50 = 11 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
400 5 1 4 3.4 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C34CC5CC(C3)CC(C5)C4)F
CHEMBL120055 5ht1a_human Human No 7.0 EC50 = 110 Funct
Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 110-250Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 110-250
393 6 2 4 2.8 CC1=CC=CC=C1N2CCN(CC2)C(=O)COC3=CC4=C(C=C3)NC=C4CCN
CHEMBL481839 5ht1a_human Human Yes 5.0 EC50 = 11000 Funct
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cellsDisplacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells
323 0 0 5 3.0 CN1C2CC3=CC4=C(C=C3C1CC5=CC6=C(C=C25)OCO6)OCO4
CHEMBL481839 5ht1a_human Human Yes 5.0 EC50 = 11000 Funct
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cellsDisplacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells
323 0 0 5 3.0 CN1C2CC3=CC4=C(C=C3C1CC5=CC6=C(C=C25)OCO6)OCO4
CHEMBL221183 5ht1a_human Human No 7.0 EC50 = 112.2 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
364 7 1 3 5.0 CC1(COC2=C1C=CC=C2OCCNCC3=CC=CC(=C3)C4=CCCC4)C
CHEMBL221183 5ht1a_human Human No 7.0 EC50 = 112.2 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
364 7 1 3 5.0 CC1(COC2=C1C=CC=C2OCCNCC3=CC=CC(=C3)C4=CCCC4)C
CHEMBL205031 5ht1a_human Human No 6.0 EC50 = 1131 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
345 3 2 3 3.8 C1CN(CC=C1C2=CNC3=CC=CC=C32)CC4CNC5=CC=CC=C5O4
CHEMBL205031 5ht1a_human Human No 6.0 EC50 = 1131 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
345 3 2 3 3.8 C1CN(CC=C1C2=CNC3=CC=CC=C32)CC4CNC5=CC=CC=C5O4
CHEMBL575290 5ht1a_human Human Yes 5.9 EC50 = 1150 Funct
Partial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assayPartial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assay
288 3 1 2 4.2 C1CNCCC1C2=CC=CC=C2OC3=CC(=CC=C3)Cl
CHEMBL575290 5ht1a_human Human Yes 5.9 EC50 = 1150 Funct
Partial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assayPartial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assay
288 3 1 2 4.2 C1CNCCC1C2=CC=CC=C2OC3=CC(=CC=C3)Cl
CHEMBL234853 5ht1a_human Human No 6.9 EC50 = 116.2 Funct
Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding
375 5 2 4 4.4 C1C(COC2=C1C3=C(C=C2)N=CC=C3)NCCCC4=CNC5=C4C=C(C=C5)F
CHEMBL234853 5ht1a_human Human No 6.9 EC50 = 116.2 Funct
Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding
375 5 2 4 4.4 C1C(COC2=C1C3=C(C=C2)N=CC=C3)NCCCC4=CNC5=C4C=C(C=C5)F
CHEMBL3805165 5ht1a_human Human No 7.9 EC50 = 12 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
447 8 1 8 4.1 CNC(=O)C1=CC(=CC=C1)OCCCCN2CCN(CC2)C3=C4C(=CC=C3)OC(O4)(F)F
CHEMBL1259033 5ht1a_human Human No 7.9 EC50 = 12 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
347 5 1 5 2.2 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CSC=C3)F
CHEMBL3805165 5ht1a_human Human No 7.9 EC50 = 12 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
447 8 1 8 4.1 CNC(=O)C1=CC(=CC=C1)OCCCCN2CCN(CC2)C3=C4C(=CC=C3)OC(O4)(F)F
CHEMBL1259033 5ht1a_human Human No 7.9 EC50 = 12 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
347 5 1 5 2.2 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CSC=C3)F
CHEMBL56 5ht1a_human Human Yes 7.9 EC50 = 12.0 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL56 5ht1a_human Human Yes 7.9 EC50 = 12.0 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL288244 5ht1a_human Human No 7.9 EC50 = 12.0 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
478 6 1 5 4.8 C1CN(CCC1(CNCC2=CC=CC(=N2)C3=CC=CS3)F)C(=O)C4=CC(=C(C=C4)Cl)Cl
CHEMBL44159 5ht1a_human Human No 7.9 EC50 = 12.3 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
446 6 1 6 3.2 C1CN(CCC1(CNCC2=NC(=CC=C2)N3C=CC=N3)F)C(=O)C4=CC(=C(C=C4)F)Cl
CHEMBL45334 5ht1a_human Human No 7.9 EC50 = 12.6 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
409 6 2 6 3.2 CNC1=CC=CC(=N1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL81095 5ht1a_human Human No 7.9 EC50 = 12.6 Funct
Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)
413 7 1 6 3.4 C1CN(CCN1CCCCNC(=O)C2=CC=C(C=C2)F)C3=C4C(=CC=C3)OCCO4
CHEMBL3805515 5ht1a_human Human No 6.9 EC50 = 120 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
466 9 1 5 4.7 CNC(=O)C1=C(C(=CC=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl)OC
CHEMBL3805515 5ht1a_human Human No 6.9 EC50 = 120 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
466 9 1 5 4.7 CNC(=O)C1=C(C(=CC=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl)OC
CHEMBL26655 5ht1a_human Human Yes 4.9 EC50 = 12000 Funct
PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]
212 1 1 1 2.3 CN1CCC(=CC1)C2=CNC3=CC=CC=C32
CHEMBL26655 5ht1a_human Human Yes 4.9 EC50 = 12000 Funct
PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]
212 1 1 1 2.3 CN1CCC(=CC1)C2=CNC3=CC=CC=C32
CHEMBL479243 5ht1a_rat Rat No 5.9 EC50 = 1210 Funct
Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS binding
434 7 1 9 1.7 CCC1=CC2C(S1)N=C(N(C2=O)N)SCCCN3CCN(CC3)C4=NC=CC=N4
CHEMBL479243 5ht1a_rat Rat No 5.9 EC50 = 1210 Funct
Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS binding
434 7 1 9 1.7 CCC1=CC2C(S1)N=C(N(C2=O)N)SCCCN3CCN(CC3)C4=NC=CC=N4
CHEMBL3805376 5ht1a_human Human No 6.9 EC50 = 122 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
436 8 1 4 4.8 CNC(=O)C1=CC=C(C=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
CHEMBL3806091 5ht1a_human Human No 6.9 EC50 = 122 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
450 8 1 4 5.1 CC1=C(C=CC=C1OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl)C(=O)NC
CHEMBL3805376 5ht1a_human Human No 6.9 EC50 = 122 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
436 8 1 4 4.8 CNC(=O)C1=CC=C(C=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
CHEMBL3806091 5ht1a_human Human No 6.9 EC50 = 122 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
450 8 1 4 5.1 CC1=C(C=CC=C1OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl)C(=O)NC
CHEMBL3805518 5ht1a_human Human No 7.9 EC50 = 13 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
443 8 1 7 4.2 CNC(=O)C1=C(C=CC(=C1)OCCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)F
CHEMBL3805559 5ht1a_human Human No 7.9 EC50 = 13 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
426 8 1 6 4.1 CNC(=O)C1=CC(=CC=C1)OCCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F
CHEMBL1259151 5ht1a_human Human No 7.9 EC50 = 13 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
341 5 1 4 2.5 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC=CC=C3)F
CHEMBL3805518 5ht1a_human Human No 7.9 EC50 = 13 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
443 8 1 7 4.2 CNC(=O)C1=C(C=CC(=C1)OCCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)F
CHEMBL3805559 5ht1a_human Human No 7.9 EC50 = 13 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
426 8 1 6 4.1 CNC(=O)C1=CC(=CC=C1)OCCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F
CHEMBL2112645 5ht1a_human Human No 7.9 EC50 = 13 Funct
Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
324 9 2 3 3.9 COC1=CC=CC=C1OCCNCCCC2=CNC3=CC=CC=C32
CHEMBL1259151 5ht1a_human Human No 7.9 EC50 = 13 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
341 5 1 4 2.5 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC=CC=C3)F
CHEMBL288992 5ht1a_human Human No 7.9 EC50 = 13.2 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
423 7 2 6 3.5 CCNC1=CC=CC(=N1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL1277007 5ht1a_human Human No 7.9 EC50 = 13.7 Funct
Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting
447 6 1 6 3.2 CC1=CC(=NC2=CC=CC=C12)N3CCN(CC3)CCCCC4=NC5=C(CCCC5)C(=O)N4N
CHEMBL1277007 5ht1a_human Human No 7.9 EC50 = 13.7 Funct
Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting
447 6 1 6 3.2 CC1=CC(=NC2=CC=CC=C12)N3CCN(CC3)CCCCC4=NC5=C(CCCC5)C(=O)N4N
CHEMBL125902 5ht1a_human Human No 7.9 EC50 = 13.7 Funct
Effective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cellsEffective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cells
364 8 2 5 3.3 C1=CC2=NC=CN=C2C(=C1)OCCNCCCC3=CNC4=C3C=C(C=C4)F
CHEMBL1259108 5ht1a_human Human No 6.9 EC50 = 130 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
404 5 1 6 3.6 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC4=C(S3)C=CS4)F
CHEMBL1259108 5ht1a_human Human No 6.9 EC50 = 130 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
404 5 1 6 3.6 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC4=C(S3)C=CS4)F
CHEMBL128 5ht1a_rat Rat Yes 5.9 EC50 = 1300 Funct
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL1774385 5ht1a_human Human No 6.9 EC50 = 134 Funct
Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding
426 8 1 6 4.3 COC1=CC=CC=C1N2CCN(CC2)CC(CCNC(=O)C3=CC4=CC=CC=C4O3)F
CHEMBL1774385 5ht1a_human Human No 6.9 EC50 = 134 Funct
Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding
426 8 1 6 4.3 COC1=CC=CC=C1N2CCN(CC2)CC(CCNC(=O)C3=CC4=CC=CC=C4O3)F
CHEMBL441546 5ht1a_human Human No 6.9 EC50 = 134.9 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
337 7 1 4 3.9 C1CC=C(C1)C2=CC(=CC=C2)CNCCOC3=CC=CC4=C3OCO4
CHEMBL441546 5ht1a_human Human No 6.9 EC50 = 134.9 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
337 7 1 4 3.9 C1CC=C(C1)C2=CC(=CC=C2)CNCCOC3=CC=CC4=C3OCO4
CHEMBL382333 5ht1a_human Human No 6.9 EC50 = 135 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
436 6 1 5 4.9 CCCN1CC(OC2=C1C=CC=C2OC)CN3CCC(=CC3)C4=CNC5=C4C=C(C=C5)F
CHEMBL382333 5ht1a_human Human No 6.9 EC50 = 135 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
436 6 1 5 4.9 CCCN1CC(OC2=C1C=CC=C2OC)CN3CCC(=CC3)C4=CNC5=C4C=C(C=C5)F
CHEMBL1457510 5ht1a_human Human No 4.9 EC50 = 13500 Funct
Agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay
325 1 1 5 2.8 COC1=C(C=CC2=C1CN3CCC4=CC5=C(C=C4C3C2)OCO5)O
CHEMBL3805434 5ht1a_human Human No 6.9 EC50 = 137 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
478 9 1 5 4.5 CC(=O)C1=CC(=CC(=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl)C(=O)NC
CHEMBL574004 5ht1a_human Human Yes 6.9 EC50 = 137 Funct
Partial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assayPartial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assay
289 3 1 4 3.8 C1CNCCC1C2=C(C=CC=C2F)OC3=CC(=CC=C3)F
CHEMBL3805434 5ht1a_human Human No 6.9 EC50 = 137 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
478 9 1 5 4.5 CC(=O)C1=CC(=CC(=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl)C(=O)NC
CHEMBL574004 5ht1a_human Human Yes 6.9 EC50 = 137 Funct
Partial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assayPartial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assay
289 3 1 4 3.8 C1CNCCC1C2=C(C=CC=C2F)OC3=CC(=CC=C3)F
CHEMBL473282 5ht1a_human Human No 6.9 EC50 = 138 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
361 6 2 4 3.8 C1CC(CN(C1)CCC2=CNC3=CC=CC=C32)C4=NC(=NC=C4)NC5CC5
CHEMBL473282 5ht1a_human Human No 6.9 EC50 = 138 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
361 6 2 4 3.8 C1CC(CN(C1)CCC2=CNC3=CC=CC=C32)C4=NC(=NC=C4)NC5CC5
CHEMBL381542 5ht1a_human Human No 5.9 EC50 = 1385 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
412 8 2 3 5.4 C1C(OC2=CC=CC=C2N1CC3=CC=CC=C3)CNCCCC4=CNC5=CC=CC=C54
CHEMBL381542 5ht1a_human Human No 5.9 EC50 = 1385 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
412 8 2 3 5.4 C1C(OC2=CC=CC=C2N1CC3=CC=CC=C3)CNCCCC4=CNC5=CC=CC=C54
CHEMBL3144354 5ht1a_human Human No 7.8 EC50 = 14.8 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
504 11 1 6 4.0 C1=CC=C(C=C1)COCC2C(C(C(O2)N3C=NNC3=S)OCC4=CC=CC=C4)OCC5=CC=CC=C5
CHEMBL42042 5ht1a_human Human No 7.8 EC50 = 14.8 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
460 6 1 6 3.5 CC1=C(N=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F)N4C=CC=N4
CHEMBL475105 5ht1a_human Human No 6.9 EC50 = 140 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
390 7 2 4 4.4 CC(C1CC1)NC2=NC=CC(=N2)C3CCCN(C3)CCC4=CNC5=CC=CC=C54
CHEMBL475105 5ht1a_human Human No 6.9 EC50 = 140 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
390 7 2 4 4.4 CC(C1CC1)NC2=NC=CC(=N2)C3CCCN(C3)CCC4=CNC5=CC=CC=C54
CHEMBL218217 5ht1a_human Human No 5.9 EC50 = 1412.5 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
361 9 1 3 5.4 CC(C)OC1=CC=CC=C1OCCNCC2=CC=CC(=C2)C3=CC=CC=C3
CHEMBL218217 5ht1a_human Human No 5.9 EC50 = 1412.5 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
361 9 1 3 5.4 CC(C)OC1=CC=CC=C1OCCNCC2=CC=CC(=C2)C3=CC=CC=C3
CHEMBL1774534 5ht1a_human Human No 5.8 EC50 = 1430 Funct
Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding
425 8 2 5 4.0 COC1=CC=CC=C1N2CCN(CC2)CC(CCNC(=O)C3=CC4=CC=CC=C4N3)F
CHEMBL1774534 5ht1a_human Human No 5.9 EC50 = 1430 Funct
Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding
425 8 2 5 4.0 COC1=CC=CC=C1N2CCN(CC2)CC(CCNC(=O)C3=CC4=CC=CC=C4N3)F
CHEMBL371300 5ht1a_human Human Yes 5.8 EC50 = 1460 Funct
Agonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP productionAgonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP production
191 2 2 4 0.1 CC(CN1C2=CC(=O)C=CC2=CN1)N
CHEMBL371300 5ht1a_human Human Yes 5.8 EC50 = 1460 Funct
Agonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP productionAgonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP production
191 2 2 4 0.1 CC(CN1C2=CC(=O)C=CC2=CN1)N
CHEMBL515438 5ht1a_human Human No 6.8 EC50 = 147 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
376 7 2 4 4.0 C1CC(CN(C1)CCC2=CNC3=CC=CC=C32)C4=NC(=NC=C4)NCC5CC5
CHEMBL515438 5ht1a_human Human No 6.8 EC50 = 147 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
376 7 2 4 4.0 C1CC(CN(C1)CCC2=CNC3=CC=CC=C32)C4=NC(=NC=C4)NCC5CC5
CHEMBL1259034 5ht1a_human Human No 7.8 EC50 = 15 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
331 5 1 5 1.9 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC=CO3)F
CHEMBL56 5ht1a_human Human Yes 7.8 EC50 = 15 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL1259034 5ht1a_human Human No 7.8 EC50 = 15 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
331 5 1 5 1.9 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC=CO3)F
CHEMBL419240 5ht1a_human Human No 7.8 EC50 = 15.7 Funct
Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
370 8 2 5 3.7 C1COC2=C(O1)C=CC=C2OCCNCCCC3=CNC4=C3C=C(C=C4)F
CHEMBL370758 5ht1a_human Human Yes 6.8 EC50 = 150 Funct
Inhibition of forskolin-induced increase in cAMP in human 5-hydroxytryptamine 1A receptor expressed HeLa cellsInhibition of forskolin-induced increase in cAMP in human 5-hydroxytryptamine 1A receptor expressed HeLa cells
378 3 0 4 2.6 C1CC2C(=O)N(CC(=O)N2C1)CN3CCN(CC3)C4=CC=CC5=CC=CC=C54
CHEMBL370758 5ht1a_human Human Yes 6.8 EC50 = 150 Funct
Inhibition of forskolin-induced increase in cAMP in human 5-hydroxytryptamine 1A receptor expressed HeLa cellsInhibition of forskolin-induced increase in cAMP in human 5-hydroxytryptamine 1A receptor expressed HeLa cells
378 3 0 4 2.6 C1CC2C(=O)N(CC(=O)N2C1)CN3CCN(CC3)C4=CC=CC5=CC=CC=C54
CHEMBL2312640 5ht1a_human Human No 4.8 EC50 = 15000 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation
493 8 1 6 4.7 C1CN(CCN1CCCCNS(=O)(=O)C2=CN=CC3=CC=CC=C32)C4=C(C(=CC=C4)Cl)Cl
CHEMBL231273 5ht1a_human Human No 6.8 EC50 = 154.9 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
415 5 1 6 2.8 C1CN(CCC1(CNCC2=NC=C(C=N2)Cl)F)C(=O)C3=CC(=C(C=C3)F)Cl
CHEMBL231273 5ht1a_human Human No 6.8 EC50 = 154.9 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
415 5 1 6 2.8 C1CN(CCC1(CNCC2=NC=C(C=N2)Cl)F)C(=O)C3=CC(=C(C=C3)F)Cl
CHEMBL221957 5ht1a_human Human No 5.8 EC50 = 1548.8 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
380 9 1 3 6.0 CC(C)OC1=CC=CC=C1OCCNCC2=CC=CC(=C2)C3=CCCCCC3
CHEMBL221957 5ht1a_human Human No 5.8 EC50 = 1548.8 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
380 9 1 3 6.0 CC(C)OC1=CC=CC=C1OCCNCC2=CC=CC(=C2)C3=CCCCCC3
CHEMBL410273 5ht1a_human Human No 6.8 EC50 = 155 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
325 5 3 4 3.5 C1C(OC2=CC=CC=C2N1)CNCCC3=CNC4=C3C=C(C=C4)F
CHEMBL410273 5ht1a_human Human No 6.8 EC50 = 155 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
325 5 3 4 3.5 C1C(OC2=CC=CC=C2N1)CNCCC3=CNC4=C3C=C(C=C4)F
CHEMBL2312639 5ht1a_human Human No 4.8 EC50 = 15500 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation
493 8 1 6 5.0 C1CN(CCN1CCCCNS(=O)(=O)C2=CC3=CC=CC=C3C=N2)C4=C(C(=CC=C4)Cl)Cl
CHEMBL1258999 5ht1a_human Human No 7.8 EC50 = 16 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
381 5 1 5 2.9 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=COC4=CC=CC=C43)F
CHEMBL1258999 5ht1a_human Human No 7.8 EC50 = 16 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
381 5 1 5 2.9 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=COC4=CC=CC=C43)F
CHEMBL464099 5ht1a_human Human Yes 6.8 EC50 = 160 Funct
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cellsDisplacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells
341 3 1 5 3.0 CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)O)OC)OC
CHEMBL297208 5ht1a_human Human No 6.8 EC50 = 162.2 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
469 6 1 5 3.0 C1CN(CCC1(CNCC2=NC(=CC=C2)N3C=CC=N3)C#N)C(=O)C4=CC(=C(C=C4)Cl)Cl
CHEMBL494678 5ht1a_human Human Yes 5.8 EC50 = 1621.8 Funct
Agonist activity at 5HT1A receptor expressed in CHO cells by GTPgammaS binding assayAgonist activity at 5HT1A receptor expressed in CHO cells by GTPgammaS binding assay
294 2 1 6 1.5 CN1CCN(CC1)C2=NC(=NC(=C2)C3=CC=C(C=C3)C#N)N
CHEMBL494678 5ht1a_human Human Yes 5.8 EC50 = 1621.8 Funct
Agonist activity at 5HT1A receptor expressed in CHO cells by GTPgammaS binding assayAgonist activity at 5HT1A receptor expressed in CHO cells by GTPgammaS binding assay
294 2 1 6 1.5 CN1CCN(CC1)C2=NC(=NC(=C2)C3=CC=C(C=C3)C#N)N
CHEMBL2312935 5ht1a_human Human No 5.8 EC50 = 1650 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation
493 8 1 6 4.8 C1CN(CCN1CCCCNS(=O)(=O)C2=CC3=CC=CC=C3N=C2)C4=C(C(=CC=C4)Cl)Cl
CHEMBL377941 5ht1a_human Human No 6.8 EC50 = 167.5 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
339 5 2 4 3.6 CN1CC(OC2=CC=CC=C21)CNCCC3=CNC4=C3C=C(C=C4)F
CHEMBL377941 5ht1a_human Human No 6.8 EC50 = 167.5 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
339 5 2 4 3.6 CN1CC(OC2=CC=CC=C21)CNCCC3=CNC4=C3C=C(C=C4)F
CHEMBL473903 5ht1a_human Human No 6.8 EC50 = 169 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
379 6 2 5 3.9 C1CC(CN(C1)CCC2=CNC3=C2C=C(C=C3)F)C4=NC(=NC=C4)NC5CC5
CHEMBL473903 5ht1a_human Human No 6.8 EC50 = 169 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
379 6 2 5 3.9 C1CC(CN(C1)CCC2=CNC3=C2C=C(C=C3)F)C4=NC(=NC=C4)NC5CC5
CHEMBL3597636 5ht1a_human Human No 7.8 EC50 = 17 Funct
Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay
455 7 2 5 4.1 C1CN(CCN1CC(CCNC(=O)C2=CC3=CC=CC=C3N=C2)O)C4=CC=CC5=CC=CC=C54
CHEMBL1259071 5ht1a_human Human No 7.8 EC50 = 17 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
426 5 1 5 3.2 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=CS3)Br)F
CHEMBL3597636 5ht1a_human Human No 7.8 EC50 = 17 Funct
Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay
455 7 2 5 4.1 C1CN(CCN1CC(CCNC(=O)C2=CC3=CC=CC=C3N=C2)O)C4=CC=CC5=CC=CC=C54
CHEMBL1259071 5ht1a_human Human No 7.8 EC50 = 17 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
426 5 1 5 3.2 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=CS3)Br)F
CHEMBL314213 5ht1a_rat Rat No 6.8 EC50 = 170 Funct
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor
325 5 2 5 3.5 CN(C)CCC1=CNC2=C1C=C(C=C2)NC3=C(C=CC=N3)[N+](=O)[O-]
CHEMBL391531 5ht1a_human Human No 6.8 EC50 = 171.6 Funct
Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding
375 5 2 4 4.4 C1C(COC2=C1C=CC3=C2C=CC=N3)NCCCC4=CNC5=C4C=C(C=C5)F
CHEMBL391531 5ht1a_human Human No 6.8 EC50 = 171.6 Funct
Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding
375 5 2 4 4.4 C1C(COC2=C1C=CC3=C2C=CC=N3)NCCCC4=CNC5=C4C=C(C=C5)F
CHEMBL1259200 5ht1a_human Human No 7.8 EC50 = 18 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
418 5 2 5 2.8 CC1=CN=C(C=C1)CNCC2(CC3CCC(C2)N3C(=O)C4=CC(=C(C=C4)F)Cl)O
CHEMBL1259032 5ht1a_human Human No 7.8 EC50 = 18 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
347 5 1 5 2.5 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC=CS3)F
CHEMBL1259200 5ht1a_human Human No 7.8 EC50 = 18 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
418 5 2 5 2.8 CC1=CN=C(C=C1)CNCC2(CC3CCC(C2)N3C(=O)C4=CC(=C(C=C4)F)Cl)O
CHEMBL1259032 5ht1a_human Human No 7.8 EC50 = 18 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
347 5 1 5 2.5 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC=CS3)F
CHEMBL596885 5ht1a_human Human No 6.8 EC50 = 180 Funct
Agonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding
289 2 0 2 3.1 CN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC#C
CHEMBL596885 5ht1a_human Human No 6.8 EC50 = 180 Funct
Agonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding
289 2 0 2 3.1 CN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC#C
CHEMBL3358509 5ht1a_human Human No 5.8 EC50 = 1800 Funct
Agonist activity at human 5HT1A receptor (unknown origin) expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1A receptor (unknown origin) expressed in CHO cells by [35S]GTPgammaS binding assay
389 7 1 4 3.8 C1CN(CCN1CCCCNC(=O)C2=CC3=C(C=C2)N=CC=C3)C4=CC=CC=C4
CHEMBL2165119 5ht1a_human Human Yes 5.8 EC50 = 1800 Funct
pERK High-Content Assay: Cell Culture: Chinese Hamster Ovary (CHO) cells stably expressing the hD2L dopamine receptor (Urban et al., Neuropsychopharmacology 32:67 (2007)) were maintained in Ham's F12 medium supplemented with 10% fetal bovine serum, 100 U/mL penicillin, 100 ug/mL streptomycin, and 0.5 ug/ml G418. On day 1 of the assay, cells were seeded onto black clear-bottom tissue culture-treated 96-well plates (Greiner, BioOne). On day 2 of the assay, cells were washed with serum-free medium (Ham's F-12, penicillin and streptomycin) and incubated in 100 uL serum-free medium overnight.Immunofluorescence: Automatic multichannel pipetters were used for liquid handling and multichannel vacuum manifolds for aspirations. Each tested concentration was typically measured in triplicate or quadruplicate. For concentration curves, half-log-dilutions were used. Drug dilutions were prepared in stimulation medium (serum-free medium, 100 mg/L ascorbic acid).pERK High-Content Assay: Cell Culture: Chinese Hamster Ovary (CHO) cells stably expressing the hD2L dopamine receptor (Urban et al., Neuropsychopharmacology 32:67 (2007)) were maintained in Ham's F12 medium supplemented with 10% fetal bovine serum, 100 U/mL penicillin, 100 ug/mL streptomycin, and 0.5 ug/ml G418. On day 1 of the assay, cells were seeded onto black clear-bottom tissue culture-treated 96-well plates (Greiner, BioOne). On day 2 of the assay, cells were washed with serum-free medium (Ham's F-12, penicillin and streptomycin) and incubated in 100 uL serum-free medium overnight.Immunofluorescence: Automatic multichannel pipetters were used for liquid handling and multichannel vacuum manifolds for aspirations. Each tested concentration was typically measured in triplicate or quadruplicate. For concentration curves, half-log-dilutions were used. Drug dilutions were prepared in stimulation medium (serum-free medium, 100 mg/L ascorbic acid).
463 7 1 5 4.6 C1CN(CCN(C1)C2=C(C(=CC=C2)Cl)Cl)CCCCOC3=NC4=C(CCC(=O)N4)C=C3
CHEMBL3358509 5ht1a_human Human No 5.8 EC50 = 1800 Funct
Agonist activity at human 5HT1A receptor (unknown origin) expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1A receptor (unknown origin) expressed in CHO cells by [35S]GTPgammaS binding assay
389 7 1 4 3.8 C1CN(CCN1CCCCNC(=O)C2=CC3=C(C=C2)N=CC=C3)C4=CC=CC=C4
CHEMBL425936 5ht1a_human Human No 6.7 EC50 = 181.5 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
355 6 3 5 3.4 COC1=CC2=C(C=C1)NCC(O2)CNCCC3=CNC4=C3C=C(C=C4)F
CHEMBL425936 5ht1a_human Human No 6.7 EC50 = 181.5 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
355 6 3 5 3.4 COC1=CC2=C(C=C1)NCC(O2)CNCCC3=CNC4=C3C=C(C=C4)F
CHEMBL234853 5ht1a_human Human No 6.7 EC50 = 181.8 Funct
Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding
375 5 2 4 4.4 C1C(COC2=C1C3=C(C=C2)N=CC=C3)NCCCC4=CNC5=C4C=C(C=C5)F
CHEMBL1277281 5ht1a_human Human No 6.7 EC50 = 182 Funct
Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting
451 6 1 7 3.5 C1CCC2=C(C1)C(=O)N(C(=N2)SCCCN3CCN(CC3)C4=NC5=CC=CC=C5C=C4)N
CHEMBL1277281 5ht1a_human Human No 6.7 EC50 = 182 Funct
Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting
451 6 1 7 3.5 C1CCC2=C(C1)C(=O)N(C(=N2)SCCCN3CCN(CC3)C4=NC5=CC=CC=C5C=C4)N
CHEMBL596297 5ht1a_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
455 8 2 4 4.1 C1CC1CN(CCCCC2=CNC3=C2C=C(C=C3)C#N)C4CC5=C(C=CC6=C5C(=O)NC6)OC4
CHEMBL596297 5ht1a_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
455 8 2 4 4.1 C1CC1CN(CCCCC2=CNC3=C2C=C(C=C3)C#N)C4CC5=C(C=CC6=C5C(=O)NC6)OC4
CHEMBL191971 5ht1a_human Human Yes 7.7 EC50 = 19.1 Funct
Binding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-SBinding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-S
498 3 1 4 5.1 CN1CCN(CC1)C2=C(C=C3CCN(C3=C2)C(=O)NC4=CC=C(C5=CC=CC=C54)C6=CC=NC=C6)Cl
CHEMBL1806874 5ht1a_human Human No 6.7 EC50 = 190 Funct
Agonist activity at 5-HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 minsAgonist activity at 5-HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins
468 9 0 5 6.0 CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OC(=O)CCCCC5CCSS5
CHEMBL203018 5ht1a_human Human No 6.7 EC50 = 190 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
407 4 1 5 4.0 CN1CC(OC2=C1C=CC=C2OC)CN3CCC(=CC3)C4=CNC5=C4C=C(C=C5)F
CHEMBL448891 5ht1a_human Human Yes 6.7 EC50 = 190 Funct
Agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay
341 3 1 5 2.9 COC1=C(C=C2C3CC4=C(CN3CCC2=C1)C(=C(C=C4)O)OC)OC
CHEMBL1806874 5ht1a_human Human No 6.7 EC50 = 190 Funct
Agonist activity at 5-HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 minsAgonist activity at 5-HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins
468 9 0 5 6.0 CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OC(=O)CCCCC5CCSS5
CHEMBL203018 5ht1a_human Human No 6.7 EC50 = 190 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
407 4 1 5 4.0 CN1CC(OC2=C1C=CC=C2OC)CN3CCC(=CC3)C4=CNC5=C4C=C(C=C5)F
CHEMBL383446 5ht1a_human Human No 6.7 EC50 = 190.5 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
367 6 2 4 4.4 CC(C)N1CC(OC2=CC=CC=C21)CNCCC3=CNC4=C3C=C(C=C4)F
CHEMBL383446 5ht1a_human Human No 6.7 EC50 = 190.5 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
367 6 2 4 4.4 CC(C)N1CC(OC2=CC=CC=C21)CNCCC3=CNC4=C3C=C(C=C4)F
CHEMBL413777 5ht1a_human Human No 6.7 EC50 = 195.0 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
354 9 1 3 5.7 CC(C)OC1=CC=CC=C1OCCNCC2=CC=CC(=C2)C3CCCC3
CHEMBL413777 5ht1a_human Human No 6.7 EC50 = 195.0 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
354 9 1 3 5.7 CC(C)OC1=CC=CC=C1OCCNCC2=CC=CC(=C2)C3CCCC3
CHEMBL382179 5ht1a_human Human No 6.7 EC50 = 196.5 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
349 7 2 3 4.4 CCCN1CC(OC2=CC=CC=C21)CNCCC3=CNC4=CC=CC=C43
CHEMBL382179 5ht1a_human Human No 6.7 EC50 = 196.5 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
349 7 2 3 4.4 CCCN1CC(OC2=CC=CC=C21)CNCCC3=CNC4=CC=CC=C43
CHEMBL1645600 5ht1a_human Human No 6.7 EC50 = 197 Funct
Agonist activity at 5HT1A receptor by GTPgammaS binding assayAgonist activity at 5HT1A receptor by GTPgammaS binding assay
312 4 1 5 3.7 C1C(CN1)OC2=C(C=CC=C2F)OC3=C(C=CC=C3Cl)F
CHEMBL1645600 5ht1a_human Human No 6.7 EC50 = 197 Funct
Agonist activity at 5HT1A receptor by GTPgammaS binding assayAgonist activity at 5HT1A receptor by GTPgammaS binding assay
312 4 1 5 3.7 C1C(CN1)OC2=C(C=CC=C2F)OC3=C(C=CC=C3Cl)F
CHEMBL126424 5ht1a_human Human No 8.7 EC50 = 2 Funct
Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
351 8 3 3 4.1 C1=CC2=C(C=CN2)C(=C1)OCCNCCCC3=CNC4=C3C=C(C=C4)F
CHEMBL45422 5ht1a_human Human Yes 8.7 EC50 = 2.1 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
423 6 2 6 3.5 CC1=C(N=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F)NC
CHEMBL1277558 5ht1a_human Human No 8.6 EC50 = 2.5 Funct
Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting
550 6 1 9 3.0 CC(=O)N1CCC2=C(C1)SC3=C2C(=O)N(C(=N3)SCCCN4CCN(CC4)C5=NC6=CC=CC=C6C=C5)N
CHEMBL1277558 5ht1a_human Human No 8.6 EC50 = 2.5 Funct
Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting
550 6 1 9 3.0 CC(=O)N1CCC2=C(C1)SC3=C2C(=O)N(C(=N3)SCCCN4CCN(CC4)C5=NC6=CC=CC=C6C=C5)N
CHEMBL78874 5ht1a_human Human No 8.6 EC50 = 2.5 Funct
Ability to influence the binding of [35S]GTP-gamma-S, to HeLa cell membranes expressing the human 5-hydroxytryptamine 1A receptorAbility to influence the binding of [35S]GTP-gamma-S, to HeLa cell membranes expressing the human 5-hydroxytryptamine 1A receptor
476 9 1 7 4.2 CCC(=O)C1=C(C(=O)N(N=C1C2=CC=CC=C2)C)NCCN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL56 5ht1a_human Human Yes 8.6 EC50 = 2.6 Funct
In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptorIn vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL56 5ht1a_human Human Yes 8.6 EC50 = 2.6 Funct
In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptorIn vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL221920 5ht1a_human Human No 8.6 EC50 = 2.6 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
362 7 1 4 3.4 C1CC=C(C1)C2=CC(=CN=C2)CNCCOC3=CC=CC4=C3OC5(C4)CC5
CHEMBL221920 5ht1a_human Human No 8.6 EC50 = 2.6 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
362 7 1 4 3.4 C1CC=C(C1)C2=CC(=CN=C2)CNCCOC3=CC=CC4=C3OC5(C4)CC5
CHEMBL43146 5ht1a_human Human No 8.6 EC50 = 2.6 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
462 6 1 5 4.1 C1CN(CCC1(CNCC2=CC=CC(=N2)C3=CC=CO3)F)C(=O)C4=CC(=C(C=C4)Cl)Cl
CHEMBL3805099 5ht1a_human Human No 8.6 EC50 = 2.7 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
443 8 1 7 4.3 CNC(=O)C1=C(C=CC(=C1)OCCCCN2CCN(CC2)C3=NSC4=CC=CC=C43)F
CHEMBL3805099 5ht1a_human Human No 8.6 EC50 = 2.7 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
443 8 1 7 4.3 CNC(=O)C1=C(C=CC(=C1)OCCCCN2CCN(CC2)C3=NSC4=CC=CC=C43)F
CHEMBL42545 5ht1a_human Human No 8.6 EC50 = 2.8 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
460 6 2 6 3.2 CC1=C(N=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F)C4=CC=NN4
CHEMBL542671 5ht1a_human Human No 8.6 EC50 = 2.8 Funct
Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)
366 6 0 5 3.2 C1CN(CCN1CCCC(=O)C2=CC=CC=C2)C3=C4C(=CC=C3)OCCO4
CHEMBL82215 5ht1a_human Human No 8.6 EC50 = 2.8 Funct
Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)
366 6 0 5 3.2 C1CN(CCN1CCCC(=O)C2=CC=CC=C2)C3=C4C(=CC=C3)OCCO4
CHEMBL384657 5ht1a_human Human No 8.5 EC50 = 2.9 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
364 7 1 4 3.7 CC1(CC2=C(O1)C(=CC=C2)OCCNCC3=CN=CC(=C3)C4=CCCC4)C
CHEMBL384657 5ht1a_human Human No 8.5 EC50 = 2.9 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
364 7 1 4 3.7 CC1(CC2=C(O1)C(=CC=C2)OCCNCC3=CN=CC(=C3)C4=CCCC4)C
CHEMBL542671 5ht1a_human Human No 8.5 EC50 = 2.9 Funct
Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)
366 6 0 5 3.2 C1CN(CCN1CCCC(=O)C2=CC=CC=C2)C3=C4C(=CC=C3)OCCO4
CHEMBL82215 5ht1a_human Human No 8.5 EC50 = 2.9 Funct
Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)
366 6 0 5 3.2 C1CN(CCN1CCCC(=O)C2=CC=CC=C2)C3=C4C(=CC=C3)OCCO4
CHEMBL126407 5ht1a_human Human No 8.5 EC50 = 2.9 Funct
Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
352 8 2 4 4.4 C1=CC2=C(C(=C1)OCCNCCCC3=CNC4=C3C=C(C=C4)F)OC=C2
CHEMBL140406 5ht1a_human Human No 8.5 EC50 = 3.0 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA
364 5 0 4 4.2 COC1=CC=CC2=C1CCCC2=CCCN3CCN(CC3)C4=CC=CC=N4
CHEMBL140406 5ht1a_human Human No 8.5 EC50 = 3.0 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA
364 5 0 4 4.2 COC1=CC=CC2=C1CCCC2=CCCN3CCN(CC3)C4=CC=CC=N4
CHEMBL46971 5ht1a_human Human No 8.5 EC50 = 3.0 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
439 6 1 5 3.8 CN(C)C1=CC=CC(=N1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)Cl)Cl)F
CHEMBL210537 5ht1a_human Human No 7.7 EC50 = 20 Funct
Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay
445 9 2 6 2.8 CC1=CC=C(C=C1)S(=O)(=O)NCCCCN2CCN(CC2)C3=CC(=CC=C3)NC(=O)C
CHEMBL209821 5ht1a_human Human Yes 7.7 EC50 = 20 Funct
Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay
451 10 2 6 3.2 CC(=O)NC1=CC=CC(=C1)N2CCN(CC2)CCCCNS(=O)(=O)CC3CCCCC3
CHEMBL1259107 5ht1a_human Human No 7.7 EC50 = 20 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
361 5 1 5 2.9 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=CS3)C)F
CHEMBL1259087 5ht1a_human Human No 7.7 EC50 = 20 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
426 5 1 5 3.2 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=C(C=CS3)Br)F
CHEMBL210537 5ht1a_human Human No 7.7 EC50 = 20 Funct
Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay
445 9 2 6 2.8 CC1=CC=C(C=C1)S(=O)(=O)NCCCCN2CCN(CC2)C3=CC(=CC=C3)NC(=O)C
CHEMBL209821 5ht1a_human Human Yes 7.7 EC50 = 20 Funct
Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay
451 10 2 6 3.2 CC(=O)NC1=CC=CC(=C1)N2CCN(CC2)CCCCNS(=O)(=O)CC3CCCCC3
CHEMBL1259107 5ht1a_human Human No 7.7 EC50 = 20 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
361 5 1 5 2.9 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=CS3)C)F
CHEMBL1259087 5ht1a_human Human No 7.7 EC50 = 20 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
426 5 1 5 3.2 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=C(C=CS3)Br)F
CHEMBL42994 5ht1a_human Human No 7.7 EC50 = 20.4 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
421 6 1 4 3.9 CN(C)C1=CC=CC(=N1)CNCC2CCN(CC2)C(=O)C3=CC(=C(C=C3)Cl)Cl
CHEMBL423181 5ht1a_human Human No 7.7 EC50 = 20.9 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA
351 5 0 4 4.2 COC1=CC2=C(CCC(C2)CCN3CCN(CC3)C4=CC=CC=N4)C=C1
CHEMBL423181 5ht1a_human Human No 7.7 EC50 = 20.9 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA
351 5 0 4 4.2 COC1=CC2=C(CCC(C2)CCN3CCN(CC3)C4=CC=CC=N4)C=C1
CHEMBL47013 5ht1a_human Human No 7.7 EC50 = 20.9 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
410 5 1 4 3.7 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)Cl)Cl)F
CHEMBL582945 5ht1a_human Human No 6.7 EC50 = 200 Funct
Agonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assay
625 12 2 8 5.7 CC1=CC=CC(=C1)C2CN(CCC3=CC(=C(C=C23)O)O)CCCCC4=CN(N=N4)CCCN5CCN(CC5)C6=CC=CC=C6OC
CHEMBL582945 5ht1a_human Human No 6.7 EC50 = 200 Funct
Agonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assay
625 12 2 8 5.7 CC1=CC=CC(=C1)C2CN(CCC3=CC(=C(C=C23)O)O)CCCCC4=CN(N=N4)CCCN5CCN(CC5)C6=CC=CC=C6OC
CHEMBL230425 5ht1a_human Human No 5.7 EC50 = 2041.7 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
410 6 2 6 2.0 C1CN(CCC1(CNCC2=NC=C(C=C2)CO)F)C(=O)C3=CC(=C(C=C3)F)Cl
CHEMBL230425 5ht1a_human Human No 5.7 EC50 = 2041.7 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
410 6 2 6 2.0 C1CN(CCC1(CNCC2=NC=C(C=C2)CO)F)C(=O)C3=CC(=C(C=C3)F)Cl
CHEMBL209324 5ht1a_human Human Yes 7.7 EC50 = 21 Funct
Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay
418 9 1 6 3.6 CC1=CC=C(C=C1)S(=O)(=O)NCCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL209324 5ht1a_human Human Yes 7.7 EC50 = 21 Funct
Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay
418 9 1 6 3.6 CC1=CC=C(C=C1)S(=O)(=O)NCCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL323441 5ht1a_human Human No 7.7 EC50 = 21 Funct
Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsStimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells
407 5 1 5 3.9 C1CN(CCC12C3=C(CO2)C4=CC=CC=C4C=C3)CC(COC5=CC=CC=C5F)O
CHEMBL44904 5ht1a_human Human No 7.7 EC50 = 21.9 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
407 6 2 4 3.7 CNC1=CC=CC(=N1)CNCC2CCN(CC2)C(=O)C3=CC(=C(C=C3)Cl)Cl
CHEMBL1774535 5ht1a_human Human No 5.7 EC50 = 2140 Funct
Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding
463 7 2 4 5.3 C1CN(CCN1CC(CCNC(=O)C2=CC3=CC=CC=C3N2)F)C4=C(C(=CC=C4)Cl)Cl
CHEMBL1774535 5ht1a_human Human No 5.7 EC50 = 2140 Funct
Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding
463 7 2 4 5.3 C1CN(CCN1CC(CCNC(=O)C2=CC3=CC=CC=C3N2)F)C4=C(C(=CC=C4)Cl)Cl
CHEMBL475694 5ht1a_human Human No 6.7 EC50 = 216 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
379 6 2 5 3.9 C1CC(CN(C1)CCC2=CNC3=C2C=CC=C3F)C4=NC(=NC=C4)NC5CC5
CHEMBL475694 5ht1a_human Human No 6.7 EC50 = 216 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
379 6 2 5 3.9 C1CC(CN(C1)CCC2=CNC3=C2C=CC=C3F)C4=NC(=NC=C4)NC5CC5
CHEMBL583752 5ht1a_human Human Yes 6.7 EC50 = 219 Funct
Partial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assayPartial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assay
271 3 1 3 3.7 C1CNCCC1C2=CC=CC=C2OC3=CC(=CC=C3)F
CHEMBL583752 5ht1a_human Human Yes 6.7 EC50 = 219 Funct
Partial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assayPartial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assay
271 3 1 3 3.7 C1CNCCC1C2=CC=CC=C2OC3=CC(=CC=C3)F
CHEMBL606864 5ht1a_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
386 5 3 4 2.6 C1C(COC2=C1C3=C(CNC3=O)C=C2)NCCCC4=CNC5=C4C=C(C=C5)C#N
CHEMBL606864 5ht1a_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
386 5 3 4 2.6 C1C(COC2=C1C3=C(CNC3=O)C=C2)NCCCC4=CNC5=C4C=C(C=C5)C#N
CHEMBL342986 5ht1a_human Human Yes 7.7 EC50 = 22 Funct
EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor
246 6 1 2 2.2 CCN(CC)CCC1=CNC2=C1C=C(C=C2)OC
CHEMBL1278088 5ht1a_human Human Yes 7.7 EC50 = 22.3 Funct
Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting
433 6 1 6 2.8 C1CCC2=C(C1)C(=O)N(C(=N2)CCCCN3CCN(CC3)C4=NC5=CC=CC=C5C=C4)N
CHEMBL1278088 5ht1a_human Human Yes 7.7 EC50 = 22.3 Funct
Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting
433 6 1 6 2.8 C1CCC2=C(C1)C(=O)N(C(=N2)CCCCN3CCN(CC3)C4=NC5=CC=CC=C5C=C4)N
CHEMBL46512 5ht1a_human Human No 7.6 EC50 = 22.9 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
479 6 1 6 4.1 C1CN(CCC1(CNCC2=CC=CC(=N2)C3=NC=CS3)F)C(=O)C4=CC(=C(C=C4)Cl)Cl
CHEMBL84107 5ht1a_rat Rat No 6.7 EC50 = 220 Funct
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor
337 4 3 5 3.6 C1CC(NC1)CC2=CNC3=C2C=C(C=C3)NC4=C(C=CC=N4)[N+](=O)[O-]
CHEMBL1645601 5ht1a_human Human No 6.7 EC50 = 225 Funct
Agonist activity at 5HT1A receptor by GTPgammaS binding assayAgonist activity at 5HT1A receptor by GTPgammaS binding assay
291 4 1 5 3.4 CC1=C(C(=CC=C1)F)OC2=C(C(=CC=C2)F)OC3CNC3
CHEMBL1645601 5ht1a_human Human No 6.7 EC50 = 225 Funct
Agonist activity at 5HT1A receptor by GTPgammaS binding assayAgonist activity at 5HT1A receptor by GTPgammaS binding assay
291 4 1 5 3.4 CC1=C(C(=CC=C1)F)OC2=C(C(=CC=C2)F)OC3CNC3
CHEMBL394530 5ht1a_human Human No 6.6 EC50 = 229.1 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
412 6 1 6 3.0 C1CN(CCC1(CNCC2=NC=C(C=C2)CF)F)C(=O)C3=CC(=C(C=C3)F)Cl
CHEMBL394530 5ht1a_human Human No 6.6 EC50 = 229.1 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
412 6 1 6 3.0 C1CN(CCC1(CNCC2=NC=C(C=C2)CF)F)C(=O)C3=CC(=C(C=C3)F)Cl
CHEMBL45305 5ht1a_human Human Yes 7.6 EC50 = 23.4 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
394 5 1 5 3.2 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL45305 5ht1a_human Human Yes 7.6 EC50 = 23.4 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
394 5 1 5 3.2 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL230327 5ht1a_human Human No 6.6 EC50 = 239.9 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
430 6 1 7 3.5 C1CN(CCC1(CNCC2=NC=C(C=C2)C(F)F)F)C(=O)C3=CC(=C(C=C3)F)Cl
CHEMBL230327 5ht1a_human Human No 6.6 EC50 = 239.9 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
430 6 1 7 3.5 C1CN(CCC1(CNCC2=NC=C(C=C2)C(F)F)F)C(=O)C3=CC(=C(C=C3)F)Cl
CHEMBL607419 5ht1a_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
434 7 2 4 4.2 C1CC1CN(CCCC2=CNC3=C2C=C(C=C3)F)C4CC5=C(C=CC6=C5C(=O)NC6)OC4
CHEMBL3805077 5ht1a_human Human No 7.6 EC50 = 24 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
436 8 1 4 4.8 CNC(=O)C1=CC(=CC=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
CHEMBL3805077 5ht1a_human Human No 7.6 EC50 = 24 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
436 8 1 4 4.8 CNC(=O)C1=CC(=CC=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
CHEMBL219486 5ht1a_human Human No 7.6 EC50 = 24.6 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
365 7 1 4 4.6 CC1(OC2=C(O1)C(=CC=C2)OCCNCC3=CC=CC(=C3)C4=CCCC4)C
CHEMBL219486 5ht1a_human Human No 7.6 EC50 = 24.6 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
365 7 1 4 4.6 CC1(OC2=C(O1)C(=CC=C2)OCCNCC3=CC=CC(=C3)C4=CCCC4)C
CHEMBL1259242 5ht1a_human Human No 6.6 EC50 = 240 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
398 5 1 5 3.8 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC4=CC=CC=C4S3)F
CHEMBL1259051 5ht1a_human Human No 6.6 EC50 = 240 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
331 5 1 5 1.6 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=COC=C3)F
CHEMBL1259242 5ht1a_human Human No 6.6 EC50 = 240 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
398 5 1 5 3.8 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC4=CC=CC=C4S3)F
CHEMBL1259051 5ht1a_human Human No 6.6 EC50 = 240 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
331 5 1 5 1.6 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=COC=C3)F
CHEMBL606149 5ht1a_human Human No 7.6 EC50 = 25 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
393 5 3 4 3.4 C1CNC(=O)C2=C1C=CC3=C2CC(CO3)NCCCC4=CNC5=C4C=C(C=C5)F
CHEMBL606149 5ht1a_human Human No 7.6 EC50 = 25 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
393 5 3 4 3.4 C1CNC(=O)C2=C1C=CC3=C2CC(CO3)NCCCC4=CNC5=C4C=C(C=C5)F
CHEMBL45305 5ht1a_human Human Yes 7.6 EC50 = 25.7 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
394 5 1 5 3.2 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL338587 5ht1a_human Human No 7.6 EC50 = 25.8 Funct
Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
347 9 3 2 4.4 C1=CC=C2C(=C1)C(=CN2)CCCCNCCOC3=CC=CC4=C3C=CN4
CHEMBL3597643 5ht1a_human Human No 6.6 EC50 = 250 Funct
Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay
427 7 2 3 5.3 C1CN(CCN1CCCCNC(=O)C2=CC3=CC=CC=C3N2)C4=CC=CC5=CC=CC=C54
CHEMBL3597643 5ht1a_human Human No 6.6 EC50 = 250 Funct
Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay
427 7 2 3 5.3 C1CN(CCN1CCCCNC(=O)C2=CC3=CC=CC=C3N2)C4=CC=CC5=CC=CC=C54
CHEMBL2165126 5ht1a_human Human Yes 5.6 EC50 = 2500 Funct
pERK High-Content Assay: Cell Culture: Chinese Hamster Ovary (CHO) cells stably expressing the hD2L dopamine receptor (Urban et al., Neuropsychopharmacology 32:67 (2007)) were maintained in Ham's F12 medium supplemented with 10% fetal bovine serum, 100 U/mL penicillin, 100 ug/mL streptomycin, and 0.5 ug/ml G418. On day 1 of the assay, cells were seeded onto black clear-bottom tissue culture-treated 96-well plates (Greiner, BioOne). On day 2 of the assay, cells were washed with serum-free medium (Ham's F-12, penicillin and streptomycin) and incubated in 100 uL serum-free medium overnight.Immunofluorescence: Automatic multichannel pipetters were used for liquid handling and multichannel vacuum manifolds for aspirations. Each tested concentration was typically measured in triplicate or quadruplicate. For concentration curves, half-log-dilutions were used. Drug dilutions were prepared in stimulation medium (serum-free medium, 100 mg/L ascorbic acid).pERK High-Content Assay: Cell Culture: Chinese Hamster Ovary (CHO) cells stably expressing the hD2L dopamine receptor (Urban et al., Neuropsychopharmacology 32:67 (2007)) were maintained in Ham's F12 medium supplemented with 10% fetal bovine serum, 100 U/mL penicillin, 100 ug/mL streptomycin, and 0.5 ug/ml G418. On day 1 of the assay, cells were seeded onto black clear-bottom tissue culture-treated 96-well plates (Greiner, BioOne). On day 2 of the assay, cells were washed with serum-free medium (Ham's F-12, penicillin and streptomycin) and incubated in 100 uL serum-free medium overnight.Immunofluorescence: Automatic multichannel pipetters were used for liquid handling and multichannel vacuum manifolds for aspirations. Each tested concentration was typically measured in triplicate or quadruplicate. For concentration curves, half-log-dilutions were used. Drug dilutions were prepared in stimulation medium (serum-free medium, 100 mg/L ascorbic acid).
462 7 1 4 5.0 C1CN(CCN(C1)C2=C(C(=CC=C2)Cl)Cl)CCCCOC3=CC4=C(CCC(=O)N4)C=C3
CHEMBL311976 5ht1a_human Human No 6.6 EC50 = 251.2 Funct
Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)
429 4 0 7 1.9 C1CN(CCN1CCN2C(=O)C3=CC=CC=C3S2(=O)=O)C4=C5C(=CC=C4)OCCO5
CHEMBL592951 5ht1a_human Human No 6.6 EC50 = 252 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
436 6 2 4 4.7 CC(C)N(CCCC1=CNC2=C1C=C(C=C2)F)C3CC4=C(C=CC5=C4C(=O)NCC5)OC3
CHEMBL592951 5ht1a_human Human No 6.6 EC50 = 252 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
436 6 2 4 4.7 CC(C)N(CCCC1=CNC2=C1C=C(C=C2)F)C3CC4=C(C=CC5=C4C(=O)NCC5)OC3
CHEMBL56 5ht1a_human Human Yes 7.6 EC50 = 26 Funct
Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL604063 5ht1a_human Human No 7.6 EC50 = 26 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
407 5 2 4 3.9 CN(CCCC1=CNC2=C1C=C(C=C2)F)C3CC4=C(C=CC5=C4C(=O)NCC5)OC3
CHEMBL3806169 5ht1a_human Human No 7.6 EC50 = 26 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
422 8 1 4 4.4 C1CN(CCN1CCCCOC2=CC=CC(=C2)C(=O)N)C3=C(C(=CC=C3)Cl)Cl
CHEMBL3804943 5ht1a_human Human No 7.6 EC50 = 26 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
466 9 1 5 4.7 CNC(=O)C1=CC(=C(C=C1)OC)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
CHEMBL1259210 5ht1a_human Human No 7.6 EC50 = 26 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
388 5 1 4 3.7 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C34CCCC(C3)CCC4)F
CHEMBL56 5ht1a_human Human Yes 7.6 EC50 = 26 Funct
Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL604063 5ht1a_human Human No 7.6 EC50 = 26 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
407 5 2 4 3.9 CN(CCCC1=CNC2=C1C=C(C=C2)F)C3CC4=C(C=CC5=C4C(=O)NCC5)OC3
CHEMBL3806169 5ht1a_human Human No 7.6 EC50 = 26 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
422 8 1 4 4.4 C1CN(CCN1CCCCOC2=CC=CC(=C2)C(=O)N)C3=C(C(=CC=C3)Cl)Cl
CHEMBL3804943 5ht1a_human Human No 7.6 EC50 = 26 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
466 9 1 5 4.7 CNC(=O)C1=CC(=C(C=C1)OC)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
CHEMBL75642 5ht1a_human Human No 7.6 EC50 = 26 Funct
Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pigCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pig
355 3 1 3 3.8 CN1CCCC1CC2=CNC3=C2C=C(C=C3)N4C=NC5=C4C=CC(=C5)C#N
CHEMBL1259210 5ht1a_human Human No 7.6 EC50 = 26 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
388 5 1 4 3.7 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C34CCCC(C3)CCC4)F
CHEMBL3084757 5ht1a_human Human No 6.6 EC50 = 270 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
365 5 2 4 2.1 CC1=CN=C(C=C1)CNCC2(CC3CCC(C2)N3C(=O)C4=CC=CC=C4)O
CHEMBL3084757 5ht1a_human Human No 6.6 EC50 = 270 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
365 5 2 4 2.1 CC1=CN=C(C=C1)CNCC2(CC3CCC(C2)N3C(=O)C4=CC=CC=C4)O
CHEMBL592029 5ht1a_human Human No 7.6 EC50 = 28 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
407 6 2 4 3.8 CCN(CCCC1=CNC2=C1C=C(C=C2)F)C3CC4=C(C=CC5=C4C(=O)NC5)OC3
CHEMBL592029 5ht1a_human Human No 7.6 EC50 = 28 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
407 6 2 4 3.8 CCN(CCCC1=CNC2=C1C=C(C=C2)F)C3CC4=C(C=CC5=C4C(=O)NC5)OC3
CHEMBL56 5ht1a_human Human Yes 7.6 EC50 = 28.2 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL56 5ht1a_human Human Yes 7.6 EC50 = 28.2 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL440854 5ht1a_human Human No 7.6 EC50 = 28.2 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
462 6 1 5 3.7 C1CN(CCC1(CNCC2=NC(=CC=C2)N3C=CC=N3)F)C(=O)C4=CC(=C(C=C4)Cl)Cl
CHEMBL45048 5ht1a_human Human No 7.5 EC50 = 28.8 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
465 8 1 6 4.4 CCN(CC)C1=C(C=CC(=N1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F)C
CHEMBL595622 5ht1a_human Human No 6.6 EC50 = 284 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
393 6 3 4 3.3 C1C(COC2=C1C3=C(CNC3=O)C=C2)NCCCCC4=CNC5=C4C=C(C=C5)F
CHEMBL595622 5ht1a_human Human No 6.6 EC50 = 284 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
393 6 3 4 3.3 C1C(COC2=C1C3=C(CNC3=O)C=C2)NCCCCC4=CNC5=C4C=C(C=C5)F
CHEMBL284092 5ht1a_human Human Yes 6.5 EC50 = 288 Funct
Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay
359 6 0 6 1.8 CC1(CC(=O)N(C(=O)C1)CCCCN2CCN(CC2)C3=NC=CC=N3)C
CHEMBL284092 5ht1a_human Human Yes 6.5 EC50 = 288 Funct
Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay
359 6 0 6 1.8 CC1(CC(=O)N(C(=O)C1)CCCCN2CCN(CC2)C3=NC=CC=N3)C
CHEMBL437314 5ht1a_human Human No 5.5 EC50 = 2890 Funct
Agonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP productionAgonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP production
191 2 2 4 0.1 CC(CN1C2=CC(=O)C=CC2=CN1)N
CHEMBL437314 5ht1a_human Human No 5.5 EC50 = 2890 Funct
Agonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP productionAgonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP production
191 2 2 4 0.1 CC(CN1C2=CC(=O)C=CC2=CN1)N
CHEMBL475090 5ht1a_human Human No 6.5 EC50 = 290 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
363 6 1 4 4.3 C1CC(CN(C1)CCC2CC3=CC=CC=C3C2)C4=NC(=NC=C4)NC5CC5
CHEMBL475090 5ht1a_human Human No 6.5 EC50 = 290 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
363 6 1 4 4.3 C1CC(CN(C1)CCC2CC3=CC=CC=C3C2)C4=NC(=NC=C4)NC5CC5
CHEMBL340705 5ht1a_human Human No 8.5 EC50 = 3 Funct
Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
345 8 2 3 4.2 C1=CC=C2C(=C1)C(=CN2)CCCNCCOC3=CC=CC4=C3N=CC=C4
CHEMBL45101 5ht1a_human Human No 8.5 EC50 = 3.0 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
444 6 2 4 3.4 C1CN(CCC1CNCC2=CC=CC(=N2)C3=CC=NN3)C(=O)C4=CC(=C(C=C4)Cl)Cl
CHEMBL111065 5ht1a_human Human No 8.5 EC50 = 3.3 Funct
Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsStimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells
418 6 1 4 4.6 CCC1=CC(=CC=C1)OCC(CN2CCC3(CC2)C4=C(CO3)C5=CC=CC=C5C=C4)O
CHEMBL42393 5ht1a_human Human No 8.5 EC50 = 3.5 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
446 6 1 6 3.6 C1CN(CCC1(CNCC2=CC=CC(=N2)C3=CC=CO3)F)C(=O)C4=CC(=C(C=C4)F)Cl
CHEMBL111713 5ht1a_human Human No 8.5 EC50 = 3.5 Funct
Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsStimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells
462 5 1 6 3.7 C1CC(=O)C2=C(C=CC(=C21)F)OCC(CN3CCC4(CC3)C5=C(CO4)C6=CC=CC=C6C=C5)O
CHEMBL423181 5ht1a_human Human No 8.5 EC50 = 3.5 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayAgonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assay
351 5 0 4 4.2 COC1=CC2=C(CCC(C2)CCN3CCN(CC3)C4=CC=CC=N4)C=C1
CHEMBL423181 5ht1a_human Human No 8.5 EC50 = 3.5 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayAgonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assay
351 5 0 4 4.2 COC1=CC2=C(CCC(C2)CCN3CCN(CC3)C4=CC=CC=N4)C=C1
CHEMBL207220 5ht1a_human Human No 8.4 EC50 = 3.6 Funct
Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay
465 10 1 6 3.4 CC(=O)NC1=CC=CC(=C1)N2CCN(CC2)CCCCN(C)S(=O)(=O)CC3CCCCC3
CHEMBL207220 5ht1a_human Human No 8.4 EC50 = 3.6 Funct
Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay
465 10 1 6 3.4 CC(=O)NC1=CC=CC(=C1)N2CCN(CC2)CCCCN(C)S(=O)(=O)CC3CCCCC3
CHEMBL360319 5ht1a_human Human No 8.4 EC50 = 3.6 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
423 6 1 6 3.3 CN(C)C1=CC=CC(=N1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL45336 5ht1a_human Human No 8.4 EC50 = 3.7 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
437 6 1 6 3.7 CC1=C(N=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F)N(C)C
CHEMBL1259072 5ht1a_human Human No 7.5 EC50 = 30 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
426 5 1 5 3.5 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC=C(S3)Br)F
CHEMBL1259139 5ht1a_human Human No 7.5 EC50 = 30 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
382 5 1 5 3.1 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=C(C=CS3)Cl)F
CHEMBL1259072 5ht1a_human Human No 7.5 EC50 = 30 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
426 5 1 5 3.5 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC=C(S3)Br)F
CHEMBL1259139 5ht1a_human Human No 7.5 EC50 = 30 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
382 5 1 5 3.1 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=C(C=CS3)Cl)F
CHEMBL1277651 5ht1a_human Human No 7.5 EC50 = 30.7 Funct
Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting
429 6 1 6 3.0 C1CN(CCN1CCCCC2=NC3=CC=CC=C3C(=O)N2N)C4=NC5=CC=CC=C5C=C4
CHEMBL1277651 5ht1a_human Human No 7.5 EC50 = 30.7 Funct
Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting
429 6 1 6 3.0 C1CN(CCN1CCCCC2=NC3=CC=CC=C3C(=O)N2N)C4=NC5=CC=CC=C5C=C4
CHEMBL295025 5ht1a_human Human No 7.5 EC50 = 30.9 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
444 6 1 4 3.7 C1CN(CCC1CNCC2=NC(=CC=C2)N3C=CC=N3)C(=O)C4=CC(=C(C=C4)Cl)Cl
CHEMBL3805046 5ht1a_human Human No 6.5 EC50 = 301 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
454 8 1 5 4.9 CNC(=O)C1=C(C(=CC=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl)F
CHEMBL3805046 5ht1a_human Human No 6.5 EC50 = 301 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
454 8 1 5 4.9 CNC(=O)C1=C(C(=CC=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl)F
CHEMBL233591 5ht1a_human Human No 6.5 EC50 = 301.2 Funct
Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding
418 7 1 4 5.7 CCCN(CCCC1=CNC2=C1C=C(C=C2)F)C3CC4=C(C=CC5=C4C=CC=N5)OC3
CHEMBL473902 5ht1a_human Human No 6.5 EC50 = 302 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
364 7 2 4 4.1 CCCNC1=NC=CC(=N1)C2CCCN(C2)CCC3=CNC4=CC=CC=C43
CHEMBL473902 5ht1a_human Human No 6.5 EC50 = 302 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
364 7 2 4 4.1 CCCNC1=NC=CC(=N1)C2CCCN(C2)CCC3=CNC4=CC=CC=C43
CHEMBL3804954 5ht1a_human Human No 6.5 EC50 = 309 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
436 8 1 4 4.8 CNC(=O)C1=CC=CC=C1OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
CHEMBL3804954 5ht1a_human Human No 6.5 EC50 = 309 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
436 8 1 4 4.8 CNC(=O)C1=CC=CC=C1OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
CHEMBL231373 5ht1a_human Human No 6.5 EC50 = 309.0 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
410 6 2 7 2.5 CNC1=NC(=NC=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL231373 5ht1a_human Human No 6.5 EC50 = 309.0 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
410 6 2 7 2.5 CNC1=NC(=NC=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL45094 5ht1a_human Human No 6.5 EC50 = 309.0 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
476 7 1 5 3.9 C1CN(CCC1(CNCC2=NC(=CC=C2)N3C=CC=N3)CF)C(=O)C4=CC(=C(C=C4)Cl)Cl
CHEMBL114452 5ht1a_human Human No 7.5 EC50 = 31 Funct
Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsStimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells
404 6 1 4 3.5 C1CN(CCC12C3=C(CO2)C4=CC=CC=C4C=C3)CC(COCC5=CC=CC=C5)O
CHEMBL81095 5ht1a_human Human No 7.5 EC50 = 31.6 Funct
Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)
413 7 1 6 3.4 C1CN(CCN1CCCCNC(=O)C2=CC=C(C=C2)F)C3=C4C(=CC=C3)OCCO4
CHEMBL1259017 5ht1a_human Human No 6.5 EC50 = 310 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
381 5 1 5 1.6 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=C4C=CC=CN4N=C3)F
CHEMBL1259017 5ht1a_human Human No 6.5 EC50 = 310 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
381 5 1 5 1.6 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=C4C=CC=CN4N=C3)F
CHEMBL1084132 5ht1a_human Human No 5.5 EC50 = 3162.3 Funct
Binding affinity to 5HT1A receptorBinding affinity to 5HT1A receptor
245 3 1 3 2.4 C1CCNC(C1)CN2CCN(C2)C3=CC=CC=C3
CHEMBL1084132 5ht1a_human Human No 5.5 EC50 = 3162.3 Funct
Binding affinity to 5HT1A receptorBinding affinity to 5HT1A receptor
245 3 1 3 2.4 C1CCNC(C1)CN2CCN(C2)C3=CC=CC=C3
CHEMBL207478 5ht1a_human Human No 7.5 EC50 = 32 Funct
Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay
425 10 1 6 2.4 CC(C)CS(=O)(=O)N(C)CCCCN1CCN(CC1)C2=CC(=CC=C2)NC(=O)C
CHEMBL1259184 5ht1a_human Human No 7.5 EC50 = 32 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
371 5 2 5 1.8 CC1=CN=C(C=C1)CNCC2(CC3CCC(C2)N3C(=O)C4=CSC=C4)O
CHEMBL207478 5ht1a_human Human No 7.5 EC50 = 32 Funct
Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay
425 10 1 6 2.4 CC(C)CS(=O)(=O)N(C)CCCCN1CCN(CC1)C2=CC(=CC=C2)NC(=O)C
CHEMBL1259184 5ht1a_human Human No 7.5 EC50 = 32 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
371 5 2 5 1.8 CC1=CN=C(C=C1)CNCC2(CC3CCC(C2)N3C(=O)C4=CSC=C4)O
CHEMBL56 5ht1a_human Human Yes 7.5 EC50 = 32.4 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL221131 5ht1a_human Human No 7.5 EC50 = 32.4 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
378 8 1 3 5.3 CCC1(CC2=C(O1)C(=CC=C2)OCCNCC3=CC=CC(=C3)C4=CCCC4)C
CHEMBL56 5ht1a_human Human Yes 7.5 EC50 = 32.4 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL221131 5ht1a_human Human No 7.5 EC50 = 32.4 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
378 8 1 3 5.3 CCC1(CC2=C(O1)C(=CC=C2)OCCNCC3=CC=CC(=C3)C4=CCCC4)C
CHEMBL478413 5ht1a_rat Rat No 6.5 EC50 = 323 Funct
Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS binding
371 6 0 6 4.5 C1CN(CCN1CCCSC2=NC3=CC=CC=C3S2)C4=CC=CC=N4
CHEMBL478413 5ht1a_rat Rat No 6.5 EC50 = 323 Funct
Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS binding
371 6 0 6 4.5 C1CN(CCN1CCCSC2=NC3=CC=CC=C3S2)C4=CC=CC=N4
CHEMBL204331 5ht1a_human Human No 6.5 EC50 = 329 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
364 7 2 3 4.7 CC(C)N1CC(OC2=CC=CC=C21)CNCCCC3=CNC4=CC=CC=C43
CHEMBL203282 5ht1a_human Human No 6.5 EC50 = 329 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
381 7 2 4 4.9 CC(C)CN1CC(OC2=CC=CC=C21)CNCCC3=CNC4=C3C=C(C=C4)F
CHEMBL204331 5ht1a_human Human No 6.5 EC50 = 329 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
364 7 2 3 4.7 CC(C)N1CC(OC2=CC=CC=C21)CNCCCC3=CNC4=CC=CC=C43
CHEMBL203282 5ht1a_human Human No 6.5 EC50 = 329 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
381 7 2 4 4.9 CC(C)CN1CC(OC2=CC=CC=C21)CNCCC3=CNC4=C3C=C(C=C4)F
CHEMBL296289 5ht1a_human Human No 7.5 EC50 = 33.1 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
437 6 1 6 3.7 CC1=CC(=NC(=C1)N(C)C)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL203067 5ht1a_human Human No 7.5 EC50 = 33.6 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
321 5 2 3 3.5 CN1CC(OC2=CC=CC=C21)CNCCC3=CNC4=CC=CC=C43
CHEMBL203067 5ht1a_human Human No 7.5 EC50 = 33.6 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
321 5 2 3 3.5 CN1CC(OC2=CC=CC=C21)CNCCC3=CNC4=CC=CC=C43
CHEMBL218313 5ht1a_human Human No 7.5 EC50 = 33.9 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
361 7 1 3 4.5 C1CC=C(C1)C2=CC(=CC=C2)CNCCOC3=CC=CC4=C3OC5(C4)CC5
CHEMBL218313 5ht1a_human Human No 7.5 EC50 = 33.9 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
361 7 1 3 4.5 C1CC=C(C1)C2=CC(=CC=C2)CNCCOC3=CC=CC4=C3OC5(C4)CC5
CHEMBL574700 5ht1a_human Human No 6.5 EC50 = 330 Funct
Agonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assay
611 11 2 8 5.4 CC1=CC=CC=C1C2CN(CCC3=CC(=C(C=C23)O)O)CCCN4C=C(N=N4)CCCN5CCN(CC5)C6=CC=CC=C6OC
CHEMBL574700 5ht1a_human Human No 6.5 EC50 = 330 Funct
Agonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assay
611 11 2 8 5.4 CC1=CC=CC=C1C2CN(CCC3=CC(=C(C=C23)O)O)CCCN4C=C(N=N4)CCCN5CCN(CC5)C6=CC=CC=C6OC
CHEMBL391531 5ht1a_human Human No 6.5 EC50 = 332.4 Funct
Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding
375 5 2 4 4.4 C1C(COC2=C1C=CC3=C2C=CC=N3)NCCCC4=CNC5=C4C=C(C=C5)F
CHEMBL382857 5ht1a_human Human No 6.5 EC50 = 336 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
374 5 2 4 4.2 CN1CC(OC2=C1C=CC(=C2)Cl)CNCCC3=CNC4=C3C=C(C=C4)F
CHEMBL382857 5ht1a_human Human No 6.5 EC50 = 336 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
374 5 2 4 4.2 CN1CC(OC2=C1C=CC(=C2)Cl)CNCCC3=CNC4=C3C=C(C=C4)F
CHEMBL140406 5ht1a_human Human No 5.5 EC50 = 3388.4 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayAgonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assay
364 5 0 4 4.2 COC1=CC=CC2=C1CCCC2=CCCN3CCN(CC3)C4=CC=CC=N4
CHEMBL140406 5ht1a_human Human No 5.5 EC50 = 3388.4 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayAgonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assay
364 5 0 4 4.2 COC1=CC=CC2=C1CCCC2=CCCN3CCN(CC3)C4=CC=CC=N4
CHEMBL592953 5ht1a_human Human No 7.5 EC50 = 34 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
436 7 2 4 4.8 CCCN(CCCC1=CNC2=C1C=C(C=C2)F)C3CC4=C(C=CC5=C4C(=O)NCC5)OC3
CHEMBL1259016 5ht1a_human Human No 7.5 EC50 = 34 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
381 5 1 5 3.2 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC4=CC=CC=C4O3)F
CHEMBL592953 5ht1a_human Human No 7.5 EC50 = 34 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
436 7 2 4 4.8 CCCN(CCCC1=CNC2=C1C=C(C=C2)F)C3CC4=C(C=CC5=C4C(=O)NCC5)OC3
CHEMBL1259016 5ht1a_human Human No 7.5 EC50 = 34 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
381 5 1 5 3.2 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC4=CC=CC=C4O3)F
CHEMBL3806224 5ht1a_human Human No 7.5 EC50 = 34.4 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
471 8 1 4 5.4 CNC(=O)C1=C(C=CC(=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl)Cl
CHEMBL3806224 5ht1a_human Human No 7.5 EC50 = 34.4 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
471 8 1 4 5.4 CNC(=O)C1=C(C=CC(=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl)Cl
CHEMBL3597649 5ht1a_human Human No 6.5 EC50 = 340 Funct
Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay
435 8 2 6 2.8 COC1=CC=CC=C1N2CCN(CC2)CC(CCNC(=O)C3=CC4=CC=CC=C4N=C3)O
CHEMBL3597649 5ht1a_human Human No 6.5 EC50 = 340 Funct
Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay
435 8 2 6 2.8 COC1=CC=CC=C1N2CCN(CC2)CC(CCNC(=O)C3=CC4=CC=CC=C4N=C3)O
CHEMBL598346 5ht1a_human Human Yes 6.5 EC50 = 341 Funct
Agonist activity at 5HT1A receptor by GTPgammaS assayAgonist activity at 5HT1A receptor by GTPgammaS assay
289 3 1 4 3.8 C1CNCCC1C2=C(C=CC=C2F)OC3=CC=CC=C3F
CHEMBL598346 5ht1a_human Human Yes 6.5 EC50 = 341 Funct
Agonist activity at 5HT1A receptor by GTPgammaS binding assayAgonist activity at 5HT1A receptor by GTPgammaS binding assay
289 3 1 4 3.8 C1CNCCC1C2=C(C=CC=C2F)OC3=CC=CC=C3F
CHEMBL598346 5ht1a_human Human Yes 6.5 EC50 = 341 Funct
Agonist activity at 5HT1A receptor by GTPgammaS assayAgonist activity at 5HT1A receptor by GTPgammaS assay
289 3 1 4 3.8 C1CNCCC1C2=C(C=CC=C2F)OC3=CC=CC=C3F
CHEMBL598346 5ht1a_human Human Yes 6.5 EC50 = 341 Funct
Agonist activity at 5HT1A receptor by GTPgammaS binding assayAgonist activity at 5HT1A receptor by GTPgammaS binding assay
289 3 1 4 3.8 C1CNCCC1C2=C(C=CC=C2F)OC3=CC=CC=C3F
CHEMBL1523325 5ht1a_human Human Yes 4.5 EC50 = 34800 Funct
PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]
314 5 3 3 2.9 C1CCC(C(C1)C(=O)NCCC2=CNC3=CC=CC=C32)C(=O)O
CHEMBL1523325 5ht1a_human Human Yes 4.5 EC50 = 34800 Funct
PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]
314 5 3 3 2.9 C1CCC(C(C1)C(=O)NCCC2=CNC3=CC=CC=C32)C(=O)O
CHEMBL1259122 5ht1a_human Human No 7.5 EC50 = 35 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
361 5 1 5 2.9 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=C(C=CS3)C)F
CHEMBL137485 5ht1a_human Human No 7.5 EC50 = 35 Funct
Effect on forskolin stimulated adenylate cyclase activity at 5-hydroxytryptamine 1A receptor of guinea pig hippocampus.Effect on forskolin stimulated adenylate cyclase activity at 5-hydroxytryptamine 1A receptor of guinea pig hippocampus.
244 3 1 2 2.9 CN1CCCC1CC2=CNC3=C2C=C(C=C3)OC
CHEMBL126536 5ht1a_human Human No 7.5 EC50 = 35 Funct
Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
363 8 2 4 4.3 C1=CC2=C(C=CC=N2)C(=C1)OCCNCCCC3=CNC4=C3C=C(C=C4)F
CHEMBL1259122 5ht1a_human Human No 7.5 EC50 = 35 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
361 5 1 5 2.9 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=C(C=CS3)C)F
CHEMBL591561 5ht1a_human Human No 6.5 EC50 = 350 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
434 6 2 4 4.3 C1CC(C1)N(CCCC2=CNC3=C2C=C(C=C3)F)C4CC5=C(C=CC6=C5C(=O)NC6)OC4
CHEMBL591561 5ht1a_human Human No 6.5 EC50 = 350 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
434 6 2 4 4.3 C1CC(C1)N(CCCC2=CNC3=C2C=C(C=C3)F)C4CC5=C(C=CC6=C5C(=O)NC6)OC4
CHEMBL593865 5ht1a_human Human No 7.4 EC50 = 36 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
448 7 2 4 4.6 C1CC1CN(CCCC2=CNC3=C2C=C(C=C3)F)C4CC5=C(C=CC6=C5C(=O)NCC6)OC4
CHEMBL593865 5ht1a_human Human No 7.4 EC50 = 36 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
448 7 2 4 4.6 C1CC1CN(CCCC2=CNC3=C2C=C(C=C3)F)C4CC5=C(C=CC6=C5C(=O)NCC6)OC4
CHEMBL3805262 5ht1a_human Human No 6.4 EC50 = 361 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
454 8 1 5 4.9 CNC(=O)C1=CC(=CC(=C1)F)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
CHEMBL3805262 5ht1a_human Human No 6.4 EC50 = 361 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
454 8 1 5 4.9 CNC(=O)C1=CC(=CC(=C1)F)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
CHEMBL231272 5ht1a_human Human No 5.4 EC50 = 3630.8 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
431 6 1 8 2.8 C1CN(CCC1(CNCC2=NC=C(C=N2)C(F)F)F)C(=O)C3=CC(=C(C=C3)F)Cl
CHEMBL231272 5ht1a_human Human No 5.4 EC50 = 3630.8 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
431 6 1 8 2.8 C1CN(CCC1(CNCC2=NC=C(C=N2)C(F)F)F)C(=O)C3=CC(=C(C=C3)F)Cl
CHEMBL114453 5ht1a_human Human No 7.4 EC50 = 37 Funct
Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsStimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells
388 5 1 3 4.5 C1CN(CCC12C3=C(CO2)C4=CC=CC=C4C=C3)CC(CCC5=CC=CC=C5)O
CHEMBL444612 5ht1a_human Human Yes 5.4 EC50 = 3700 Funct
EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor
234 5 1 2 3.6 CCN(CC)CCC1=CNC2=C1C=CC(=C2)F
CHEMBL383688 5ht1a_human Human No 6.4 EC50 = 386 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
393 4 2 5 3.8 COC1=CC=CC2=C1OC(CN2)CN3CCC(=CC3)C4=CNC5=C4C=C(C=C5)F
CHEMBL383688 5ht1a_human Human No 6.4 EC50 = 386 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
393 4 2 5 3.8 COC1=CC=CC2=C1OC(CN2)CN3CCC(=CC3)C4=CNC5=C4C=C(C=C5)F
CHEMBL230963 5ht1a_human Human Yes 6.4 EC50 = 389.1 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
395 5 1 6 2.6 CC1=CN=C(N=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL230963 5ht1a_human Human Yes 6.4 EC50 = 389.1 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
395 5 1 6 2.6 CC1=CN=C(N=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL1259109 5ht1a_human Human No 7.4 EC50 = 39 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
404 5 1 6 3.9 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC4=C(S3)SC=C4)F
CHEMBL1259109 5ht1a_human Human No 7.4 EC50 = 39 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
404 5 1 6 3.9 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC4=C(S3)SC=C4)F
CHEMBL44841 5ht1a_human Human No 7.4 EC50 = 39.8 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
460 6 2 5 2.7 C1CN(CCC1(CNCC2=NC(=CC=C2)N3C=CC=N3)O)C(=O)C4=CC(=C(C=C4)Cl)Cl
CHEMBL236518 5ht1a_human Human No 6.4 EC50 = 394 Funct
Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as 5-HT-stimulated [35S]GTPgammaS bindingAntagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as 5-HT-stimulated [35S]GTPgammaS binding
302 7 3 3 3.7 C1CCC(CC1)NCCC(COC2=CC=CC3=C2C=CN3)O
CHEMBL236518 5ht1a_human Human No 6.4 EC50 = 394 Funct
Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as 5-HT-stimulated [35S]GTPgammaS bindingAntagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as 5-HT-stimulated [35S]GTPgammaS binding
302 7 3 3 3.7 C1CCC(CC1)NCCC(COC2=CC=CC3=C2C=CN3)O
CHEMBL595744 5ht1a_human Human No 8.4 EC50 = 4 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
411 5 3 5 3.5 C1CNC(=O)C2=C3CC(COC3=C(C=C21)F)NCCCC4=CNC5=C4C=C(C=C5)F
CHEMBL595744 5ht1a_human Human No 8.4 EC50 = 4 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
411 5 3 5 3.5 C1CNC(=O)C2=C3CC(COC3=C(C=C21)F)NCCCC4=CNC5=C4C=C(C=C5)F
CHEMBL340301 5ht1a_human Human No 8.4 EC50 = 4 Funct
Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
333 8 3 2 4.0 C1=CC=C2C(=C1)C(=CN2)CCCNCCOC3=CC=CC4=C3C=CN4
CHEMBL3805860 5ht1a_human Human No 8.4 EC50 = 4.3 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
425 8 1 6 4.2 CNC(=O)C1=CC(=CC=C1)OCCCCN2CCN(CC2)C3=NSC4=CC=CC=C43
CHEMBL3805860 5ht1a_human Human No 8.4 EC50 = 4.3 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
425 8 1 6 4.2 CNC(=O)C1=CC(=CC=C1)OCCCCN2CCN(CC2)C3=NSC4=CC=CC=C43
CHEMBL126484 5ht1a_human Human No 8.4 EC50 = 4.3 Funct
Effective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cellsEffective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cells
342 9 2 4 4.0 COC1=CC=CC=C1OCCNCCCC2=CNC3=C2C=C(C=C3)F
CHEMBL338982 5ht1a_human Human No 8.3 EC50 = 4.7 Funct
Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
354 8 2 4 4.0 C1COC2=C1C=CC=C2OCCNCCCC3=CNC4=C3C=C(C=C4)F
CHEMBL127171 5ht1a_human Human No 8.3 EC50 = 4.7 Funct
Effective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cellsEffective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cells
360 9 2 5 4.1 COC1=C(C=C(C=C1)F)OCCNCCCC2=CNC3=C2C=C(C=C3)F
CHEMBL515573 5ht1a_human Human No 7.4 EC50 = 40.7 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
380 8 2 5 3.1 COCCNC1=NC=CC(=N1)C2CCCN(C2)CCC3=CNC4=CC=CC=C43
CHEMBL515573 5ht1a_human Human No 7.4 EC50 = 40.7 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
380 8 2 5 3.1 COCCNC1=NC=CC(=N1)C2CCCN(C2)CCC3=CNC4=CC=CC=C43
CHEMBL431332 5ht1a_human Human No 6.4 EC50 = 407.4 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
408 6 1 5 3.7 CCC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL49 5ht1a_human Human Yes 7.4 EC50 = 41 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
386 6 0 6 2.6 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4
CHEMBL49 5ht1a_human Human Yes 7.4 EC50 = 41 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
386 6 0 6 2.6 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4
CHEMBL126484 5ht1a_human Human No 7.4 EC50 = 41.6 Funct
Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
342 9 2 4 4.0 COC1=CC=CC=C1OCCNCCCC2=CNC3=C2C=C(C=C3)F
CHEMBL203726 5ht1a_human Human No 6.4 EC50 = 418 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
422 5 1 5 4.3 CCN1CC(OC2=C1C=CC=C2OC)CN3CCC(=CC3)C4=CNC5=C4C=C(C=C5)F
CHEMBL203726 5ht1a_human Human No 6.4 EC50 = 418 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
422 5 1 5 4.3 CCN1CC(OC2=C1C=CC=C2OC)CN3CCC(=CC3)C4=CNC5=C4C=C(C=C5)F
CHEMBL1259121 5ht1a_human Human No 7.4 EC50 = 42 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
361 5 1 5 2.9 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC=C(S3)C)F
CHEMBL1259121 5ht1a_human Human No 7.4 EC50 = 42 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
361 5 1 5 2.9 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC=C(S3)C)F
CHEMBL396062 5ht1a_human Human No 7.4 EC50 = 42.7 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
444 6 2 7 3.2 CNC1=NC(=NC=C1Cl)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL396062 5ht1a_human Human No 7.4 EC50 = 42.7 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
444 6 2 7 3.2 CNC1=NC(=NC=C1Cl)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL3597637 5ht1a_human Human No 7.4 EC50 = 43 Funct
Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay
453 8 1 5 4.4 COC1=C(C=CC=C1Cl)N2CCN(CC2)CCCCNC(=O)C3=CC4=CC=CC=C4N=C3
CHEMBL3597637 5ht1a_human Human No 7.4 EC50 = 43 Funct
Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay
453 8 1 5 4.4 COC1=C(C=CC=C1Cl)N2CCN(CC2)CCCCNC(=O)C3=CC4=CC=CC=C4N=C3
CHEMBL593281 5ht1a_human Human No 6.4 EC50 = 436 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
484 6 2 4 4.5 C1C(COC2=C1C3=C(CNC3=O)C=C2)N(CCCC4=CNC5=C4C=C(C=C5)F)C(=O)C6=CC=CC=C6
CHEMBL593281 5ht1a_human Human No 6.4 EC50 = 436 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
484 6 2 4 4.5 C1C(COC2=C1C3=C(CNC3=O)C=C2)N(CCCC4=CNC5=C4C=C(C=C5)F)C(=O)C6=CC=CC=C6
CHEMBL124818 5ht1a_human Human No 7.4 EC50 = 44 Funct
Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
338 10 2 3 4.2 COC1=CC=CC=C1OCCNCCCCC2=CNC3=CC=CC=C32
CHEMBL1774538 5ht1a_human Human No 6.4 EC50 = 440 Funct
Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding
442 8 1 6 4.9 COC1=CC=CC=C1N2CCN(CC2)CC(CCNC(=O)C3=CC4=CC=CC=C4S3)F
CHEMBL1774538 5ht1a_human Human No 6.4 EC50 = 440 Funct
Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding
442 8 1 6 4.9 COC1=CC=CC=C1N2CCN(CC2)CC(CCNC(=O)C3=CC4=CC=CC=C4S3)F
CHEMBL231372 5ht1a_human Human No 6.4 EC50 = 446.7 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
411 6 1 7 2.5 COC1=NC(=NC=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL231372 5ht1a_human Human No 6.4 EC50 = 446.7 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
411 6 1 7 2.5 COC1=NC(=NC=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL1259138 5ht1a_human Human No 7.3 EC50 = 46 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
382 5 1 5 3.5 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC=C(S3)Cl)F
CHEMBL125902 5ht1a_human Human No 7.3 EC50 = 46 Funct
Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
364 8 2 5 3.3 C1=CC2=NC=CN=C2C(=C1)OCCNCCCC3=CNC4=C3C=C(C=C4)F
CHEMBL1259138 5ht1a_human Human No 7.3 EC50 = 46 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
382 5 1 5 3.5 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC=C(S3)Cl)F
CHEMBL221743 5ht1a_human Human No 7.3 EC50 = 46.8 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
366 9 1 3 5.4 CC(C)OC1=CC=CC=C1OCCNCC2=CC=CC(=C2)C3=CCCCC3
CHEMBL221743 5ht1a_human Human No 7.3 EC50 = 46.8 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
366 9 1 3 5.4 CC(C)OC1=CC=CC=C1OCCNCC2=CC=CC(=C2)C3=CCCCC3
CHEMBL80189 5ht1a_human Human No 6.3 EC50 = 460 Funct
Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pigCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pig
305 4 1 3 2.8 CN(C)CCC1=CNC2=C1C=C(C=C2)N3C=NC4=C3N=CC=C4
CHEMBL3805826 5ht1a_human Human No 6.3 EC50 = 464 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
492 12 1 4 6.6 CCCCCNC(=O)C1=CC(=CC=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
CHEMBL3805826 5ht1a_human Human No 6.3 EC50 = 464 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
492 12 1 4 6.6 CCCCCNC(=O)C1=CC(=CC=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
CHEMBL1259223 5ht1a_human Human No 7.3 EC50 = 47 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
386 5 1 4 3.1 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C34CC5CC(C3)CC4C5)F
CHEMBL83597 5ht1a_rat Rat Yes 7.3 EC50 = 47 Funct
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor
351 4 2 5 4.1 CN1CCCC1CC2=CNC3=C2C=C(C=C3)NC4=C(C=CC=N4)[N+](=O)[O-]
CHEMBL1259223 5ht1a_human Human No 7.3 EC50 = 47 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
386 5 1 4 3.1 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C34CC5CC(C3)CC4C5)F
CHEMBL46379 5ht1a_human Human No 7.3 EC50 = 47.9 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
437 6 1 6 3.7 CC1=C(N=C(C=C1)N(C)C)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL1259224 5ht1a_human Human No 7.3 EC50 = 48 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
434 5 1 4 3.3 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C34CC5CC(C3)CC(C5)(C4)Cl)F
CHEMBL1259224 5ht1a_human Human No 7.3 EC50 = 48 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
434 5 1 4 3.3 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C34CC5CC(C3)CC(C5)(C4)Cl)F
CHEMBL589141 5ht1a_human Human No 7.3 EC50 = 49 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
448 8 2 4 4.5 C1CC1CN(CCCCC2=CNC3=C2C=C(C=C3)F)C4CC5=C(C=CC6=C5C(=O)NC6)OC4
CHEMBL589141 5ht1a_human Human No 7.3 EC50 = 49 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
448 8 2 4 4.5 C1CC1CN(CCCCC2=CNC3=C2C=C(C=C3)F)C4CC5=C(C=CC6=C5C(=O)NC6)OC4
CHEMBL46467 5ht1a_human Human No 8.3 EC50 = 5.0 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
461 6 1 5 4.1 C1CN(CCC1CNCC2=CC=CC(=N2)C3=NC=CS3)C(=O)C4=CC(=C(C=C4)Cl)Cl
CHEMBL3805704 5ht1a_human Human No 8.3 EC50 = 5.1 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
424 8 1 5 4.5 CNC(=O)C1=CC(=CC=C1)OCCCCN2CCN(CC2)C3=C4C=CSC4=CC=C3
CHEMBL3805704 5ht1a_human Human No 8.3 EC50 = 5.1 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
424 8 1 5 4.5 CNC(=O)C1=CC(=CC=C1)OCCCCN2CCN(CC2)C3=C4C=CSC4=CC=C3
CHEMBL42294 5ht1a_human Human No 8.3 EC50 = 5.2 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
444 6 1 4 4.2 C1CN(CCC1CNCC2=CC=CC(=N2)C3=CC=CO3)C(=O)C4=CC(=C(C=C4)Cl)Cl
CHEMBL543377 5ht1a_human Human No 8.3 EC50 = 5.2 Funct
Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)
384 6 0 6 3.3 C1CN(CCN1CCCC(=O)C2=CC=C(C=C2)F)C3=C4C(=CC=C3)OCCO4
CHEMBL81118 5ht1a_human Human No 8.3 EC50 = 5.2 Funct
Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)
384 6 0 6 3.3 C1CN(CCN1CCCC(=O)C2=CC=C(C=C2)F)C3=C4C(=CC=C3)OCCO4
CHEMBL311015 5ht1a_human Human No 8.2 EC50 = 5.8 Funct
Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)
421 6 0 6 3.0 C1CN(CCN1CCCCN2C(=O)C3=CC=CC=C3C2=O)C4=C5C(=CC=C4)OCCO5
CHEMBL295662 5ht1a_human Human No 8.2 EC50 = 5.8 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
419 6 1 5 3.6 CC1=C(C=C(C=C1)C(=O)N2CCC(CC2)(CNCC3=NC(=CC=C3)N(C)C)F)Cl
CHEMBL42618 5ht1a_human Human No 8.2 EC50 = 5.8 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
460 6 1 4 4.8 C1CN(CCC1CNCC2=CC=CC(=N2)C3=CC=CS3)C(=O)C4=CC(=C(C=C4)Cl)Cl
CHEMBL56 5ht1a_human Human Yes 8.2 EC50 = 5.8 Funct
EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL221692 5ht1a_human Human Yes 8.2 EC50 = 5.9 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
405 4 0 6 3.7 C1CN(CCN1CC2=CN=CC(=C2)C3=CC=C(C=C3)F)C4=C5C(=CC=C4)OCCO5
CHEMBL221692 5ht1a_human Human Yes 8.2 EC50 = 5.9 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
405 4 0 6 3.7 C1CN(CCN1CC2=CN=CC(=C2)C3=CC=C(C=C3)F)C4=C5C(=CC=C4)OCCO5
CHEMBL1259198 5ht1a_human Human No 7.3 EC50 = 50 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
412 6 1 6 3.1 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CSC(=C3OC)Cl)F
CHEMBL421064 5ht1a_human Human No 7.3 EC50 = 50 Funct
Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 50-550Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 50-550
378 6 2 4 2.5 C1CN(CCN1C2=CC=CC=C2)C(=O)COC3=CC4=C(C=C3)NC=C4CCN
CHEMBL1259198 5ht1a_human Human No 7.3 EC50 = 50 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
412 6 1 6 3.1 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CSC(=C3OC)Cl)F
CHEMBL1802360 5ht1a_human Human Yes 7.3 EC50 = 50.1 Funct
Activity at 5HT1A receptorActivity at 5HT1A receptor
369 6 1 4 4.1 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCOC4=CC=C(C=C4)F
CHEMBL1802360 5ht1a_human Human Yes 7.3 EC50 = 50.1 Funct
Activity at 5HT1A receptorActivity at 5HT1A receptor
369 6 1 4 4.1 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCOC4=CC=C(C=C4)F
CHEMBL56 5ht1a_human Human Yes 7.3 EC50 = 51.3 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayAgonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assay
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL56 5ht1a_human Human Yes 7.3 EC50 = 51.3 Funct
Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayAgonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assay
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL475502 5ht1a_human Human No 7.3 EC50 = 51.4 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
380 8 3 5 3.4 C1CC(CN(C1)CCC2=CNC3=CC=CC=C32)C4=NC(=NC=C4)NCCCO
CHEMBL475502 5ht1a_human Human No 7.3 EC50 = 51.4 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
380 8 3 5 3.4 C1CC(CN(C1)CCC2=CNC3=CC=CC=C32)C4=NC(=NC=C4)NCCCO
CHEMBL348588 5ht1a_human Human Yes 5.3 EC50 = 5100 Funct
PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]
174 3 2 1 2.1 CNCCC1=CNC2=CC=CC=C21
CHEMBL348588 5ht1a_human Human Yes 5.3 EC50 = 5100 Funct
PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]
174 3 2 1 2.1 CNCCC1=CNC2=CC=CC=C21
CHEMBL1259181 5ht1a_human Human No 7.3 EC50 = 52 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
391 5 1 4 3.7 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC4=CC=CC=C4C=C3)F
CHEMBL1259181 5ht1a_human Human No 7.3 EC50 = 52 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
391 5 1 4 3.7 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC4=CC=CC=C4C=C3)F
CHEMBL206130 5ht1a_human Human No 7.3 EC50 = 52.2 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
355 6 3 5 3.4 COC1=CC=CC2=C1OC(CN2)CNCCC3=CNC4=C3C=C(C=C4)F
CHEMBL206130 5ht1a_human Human No 7.3 EC50 = 52.2 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
355 6 3 5 3.4 COC1=CC=CC2=C1OC(CN2)CNCCC3=CNC4=C3C=C(C=C4)F
CHEMBL119455 5ht1a_rat Rat No 5.3 EC50 = 5200 Funct
Ability to inhibit 5-HT sensitive,forskolin-stimulated adenylyl cyclase(FSC) activity in rat hippocampal membranes mediated through 5-hydroxytryptamine 1A receptorAbility to inhibit 5-HT sensitive,forskolin-stimulated adenylyl cyclase(FSC) activity in rat hippocampal membranes mediated through 5-hydroxytryptamine 1A receptor
251 0 1 2 2.7 CN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)O
CHEMBL594357 5ht1a_human Human No 7.3 EC50 = 54 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
448 6 2 4 4.8 C1CC(C1)N(CCCC2=CNC3=C2C=C(C=C3)F)C4CC5=C(C=CC6=C5C(=O)NCC6)OC4
CHEMBL1259153 5ht1a_human Human No 7.3 EC50 = 54 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
394 6 1 6 3.4 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC=C(S3)SC)F
CHEMBL594357 5ht1a_human Human No 7.3 EC50 = 54 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
448 6 2 4 4.8 C1CC(C1)N(CCCC2=CNC3=C2C=C(C=C3)F)C4CC5=C(C=CC6=C5C(=O)NCC6)OC4
CHEMBL1259153 5ht1a_human Human No 7.3 EC50 = 54 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
394 6 1 6 3.4 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC=C(S3)SC)F
CHEMBL53510 5ht1a_rat Rat Yes 7.3 EC50 = 55 Funct
Ability to inhibit 5-HT sensitive,forskolin-stimulated adenylyl cyclase(FSC) activity in rat hippocampal membranes mediated through 5-hydroxytryptamine 1A receptorAbility to inhibit 5-HT sensitive,forskolin-stimulated adenylyl cyclase(FSC) activity in rat hippocampal membranes mediated through 5-hydroxytryptamine 1A receptor
265 0 1 2 3.0 CC1=C(C2=C(CC3C4=C2C=CC=C4CCN3C)C=C1)O
CHEMBL608728 5ht1a_human Human No 7.3 EC50 = 56 Funct
Agonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding
291 3 0 2 3.6 CN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC=C
CHEMBL608728 5ht1a_human Human No 7.3 EC50 = 56 Funct
Agonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding
291 3 0 2 3.6 CN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC=C
CHEMBL340895 5ht1a_human Human No 7.3 EC50 = 56 Funct
Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
370 8 2 5 4.5 C1=CC2=C(C=C1F)C(=CN2)CCCNCCOC3=C4C(=CC(=C3)F)C=CO4
CHEMBL31115 5ht1a_human Human Yes 6.3 EC50 = 564 Funct
Tested for functional response on CHO cells expressing cloned human 5-hydroxytryptamine 1A receptorTested for functional response on CHO cells expressing cloned human 5-hydroxytryptamine 1A receptor
204 3 2 2 1.0 CC(CC1=CNC2=C1C=C(C=C2)OC)N
CHEMBL1259123 5ht1a_human Human No 7.2 EC50 = 59 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
438 5 1 6 4.5 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=C(C4=C(S3)SC=C4)Cl)F
CHEMBL1259123 5ht1a_human Human No 7.2 EC50 = 59 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
438 5 1 6 4.5 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=C(C4=C(S3)SC=C4)Cl)F
CHEMBL3344459 5ht1a_human Human No 6.2 EC50 = 590 Funct
Agonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assay
343 3 1 4 4.3 CC(C)CC1=CC2=C(S1)CC3C4=CC(=C(C=C4CCN3C2)OC)O
CHEMBL3344459 5ht1a_human Human No 6.2 EC50 = 590 Funct
Agonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assay
343 3 1 4 4.3 CC(C)CC1=CC2=C(S1)CC3C4=CC(=C(C=C4CCN3C2)OC)O
CHEMBL3805649 5ht1a_human Human No 8.2 EC50 = 6 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
442 8 1 6 4.6 CNC(=O)C1=C(C=CC(=C1)OCCCCN2CCN(CC2)C3=C4C=CSC4=CC=C3)F
CHEMBL3805649 5ht1a_human Human No 8.2 EC50 = 6 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
442 8 1 6 4.6 CNC(=O)C1=C(C=CC(=C1)OCCCCN2CCN(CC2)C3=C4C=CSC4=CC=C3)F
CHEMBL311275 5ht1a_human Human No 8.2 EC50 = 6.0 Funct
Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)
352 6 0 4 4.2 C1CN(CCN1CCCCC2=CC=CC=C2)C3=C4C(=CC=C3)OCCO4
CHEMBL375297 5ht1a_human Human No 8.2 EC50 = 6.5 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
351 7 1 4 3.9 C1CC=C(C1)C2=CC(=CC=C2)CNCCOC3=CC=CC4=C3OCCO4
CHEMBL375297 5ht1a_human Human No 8.2 EC50 = 6.5 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
351 7 1 4 3.9 C1CC=C(C1)C2=CC(=CC=C2)CNCCOC3=CC=CC4=C3OCCO4
CHEMBL1259155 5ht1a_human Human No 8.2 EC50 = 6.6 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
392 5 2 5 2.2 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)O
CHEMBL1259155 5ht1a_human Human No 8.2 EC50 = 6.6 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
392 5 2 5 2.2 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)O
CHEMBL1742477 5ht1a_human Human Yes 8.2 EC50 = 6.6 Funct
Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cellsCompound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells
415 6 2 7 2.0 C1CN(CCN1CCNC(=O)C2=CC=C(C=C2)F)C3=C4C(=CC=C3)OC(CO4)CO
CHEMBL69326 5ht1a_human Human Yes 8.2 EC50 = 6.6 Funct
Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cellsCompound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells
415 6 2 7 2.0 C1CN(CCN1CCNC(=O)C2=CC=C(C=C2)F)C3=C4C(=CC=C3)OC(CO4)CO
CHEMBL44118 5ht1a_human Human No 8.2 EC50 = 6.6 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
425 6 2 5 3.7 CNC1=CC=CC(=N1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)Cl)Cl)F
CHEMBL311275 5ht1a_human Human No 8.2 EC50 = 6.8 Funct
Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)
352 6 0 4 4.2 C1CN(CCN1CCCCC2=CC=CC=C2)C3=C4C(=CC=C3)OCCO4
CHEMBL379984 5ht1a_human Human No 7.2 EC50 = 60 Funct
Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay
411 10 2 6 2.2 CC(C)CS(=O)(=O)NCCCCN1CCN(CC1)C2=CC(=CC=C2)NC(=O)C
CHEMBL379984 5ht1a_human Human No 7.2 EC50 = 60 Funct
Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay
411 10 2 6 2.2 CC(C)CS(=O)(=O)NCCCCN1CCN(CC1)C2=CC(=CC=C2)NC(=O)C
CHEMBL126253 5ht1a_human Human No 7.2 EC50 = 60.8 Funct
Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
344 8 2 2 5.2 C1=CC=C2C(=C1)C=CC=C2OCCNCCCC3=CNC4=CC=CC=C43
CHEMBL1774532 5ht1a_human Human No 6.2 EC50 = 600 Funct
Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding
456 9 1 7 4.3 COC1=CC2=C(C=C1)OC(=C2)C(=O)NCCC(CN3CCN(CC3)C4=CC=CC=C4OC)F
CHEMBL1258996 5ht1a_human Human No 6.2 EC50 = 600 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
416 5 2 5 2.0 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C34CC5CC(C3)CC(C5)(C4)O)F
CHEMBL1774532 5ht1a_human Human No 6.2 EC50 = 600 Funct
Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding
456 9 1 7 4.3 COC1=CC2=C(C=C1)OC(=C2)C(=O)NCCC(CN3CCN(CC3)C4=CC=CC=C4OC)F
CHEMBL1258996 5ht1a_human Human No 6.2 EC50 = 600 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
416 5 2 5 2.0 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C34CC5CC(C3)CC(C5)(C4)O)F
CHEMBL594829 5ht1a_human Human No 7.2 EC50 = 62 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
379 5 3 4 3.0 C1C(COC2=C1C3=C(CNC3=O)C=C2)NCCCC4=CNC5=C4C=C(C=C5)F
CHEMBL1255610 5ht1a_human Human No 7.2 EC50 = 62 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
456 6 1 6 3.2 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CSC(=C3OC)Br)F
CHEMBL594829 5ht1a_human Human No 7.2 EC50 = 62 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
379 5 3 4 3.0 C1C(COC2=C1C3=C(CNC3=O)C=C2)NCCCC4=CNC5=C4C=C(C=C5)F
CHEMBL1255610 5ht1a_human Human No 7.2 EC50 = 62 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
456 6 1 6 3.2 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CSC(=C3OC)Br)F
CHEMBL233591 5ht1a_human Human No 6.2 EC50 = 628.6 Funct
Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding
418 7 1 4 5.7 CCCN(CCCC1=CNC2=C1C=C(C=C2)F)C3CC4=C(C=CC5=C4C=CC=N5)OC3
CHEMBL233591 5ht1a_human Human No 6.2 EC50 = 628.6 Funct
Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding
418 7 1 4 5.7 CCCN(CCCC1=CNC2=C1C=C(C=C2)F)C3CC4=C(C=CC5=C4C=CC=N5)OC3
CHEMBL1259090 5ht1a_human Human No 7.2 EC50 = 63 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
484 5 1 7 3.2 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=C4C(=C(S3)Br)OCCO4)F
CHEMBL1259090 5ht1a_human Human No 7.2 EC50 = 63 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
484 5 1 7 3.2 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=C4C(=C(S3)Br)OCCO4)F
CHEMBL231068 5ht1a_human Human Yes 6.2 EC50 = 631.0 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
390 4 1 6 3.3 C1CN(CCN1CCN2C3=CC=CC=C3NC2=O)C4=CC=CC(=C4)C(F)(F)F
CHEMBL231068 5ht1a_human Human Yes 6.2 EC50 = 631.0 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
390 4 1 6 3.3 C1CN(CCN1CCN2C3=CC=CC=C3NC2=O)C4=CC=CC(=C4)C(F)(F)F
CHEMBL311976 5ht1a_human Human No 6.2 EC50 = 631.0 Funct
Compound was tested for its potency against 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)
429 4 0 7 1.9 C1CN(CCN1CCN2C(=O)C3=CC=CC=C3S2(=O)=O)C4=C5C(=CC=C4)OCCO5
CHEMBL474090 5ht1a_human Human No 7.2 EC50 = 65 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
394 9 2 5 3.4 COCCCNC1=NC=CC(=N1)C2CCCN(C2)CCC3=CNC4=CC=CC=C43
CHEMBL474090 5ht1a_human Human No 7.2 EC50 = 65 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
394 9 2 5 3.4 COCCCNC1=NC=CC(=N1)C2CCCN(C2)CCC3=CNC4=CC=CC=C43
CHEMBL386988 5ht1a_human Human No 7.2 EC50 = 67.6 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
368 9 1 4 5.0 CC(C)OC1=CC=CC=C1OCCNCC2=CC=CC(=C2)C3=CSC=C3
CHEMBL386988 5ht1a_human Human No 7.2 EC50 = 67.6 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
368 9 1 4 5.0 CC(C)OC1=CC=CC=C1OCCNCC2=CC=CC(=C2)C3=CSC=C3
CHEMBL8412 5ht1a_human Human Yes 7.2 EC50 = 67.6 Funct
Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cellsCompound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells
401 6 0 7 1.5 C1CN(CCN1CCCCN2C(=O)C3=CC=CC=C3S2(=O)=O)C4=NC=CC=N4
CHEMBL142936 5ht1a_human Human Yes 6.2 EC50 = 680 Funct
EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor
216 5 1 1 3.3 CCN(CC)CCC1=CNC2=CC=CC=C21
CHEMBL425833 5ht1a_human Human No 7.2 EC50 = 69.2 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
414 5 1 5 3.5 C1CN(CCC1(CNCC2=NC=C(C=C2)Cl)F)C(=O)C3=CC(=C(C=C3)F)Cl
CHEMBL220809 5ht1a_human Human No 7.2 EC50 = 69.2 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
351 9 1 3 4.9 CC(C)OC1=CC=CC=C1OCCNCC2=CC=CC(=C2)C3=CCCC3
CHEMBL425833 5ht1a_human Human No 7.2 EC50 = 69.2 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
414 5 1 5 3.5 C1CN(CCC1(CNCC2=NC=C(C=C2)Cl)F)C(=O)C3=CC(=C(C=C3)F)Cl
CHEMBL220809 5ht1a_human Human No 7.2 EC50 = 69.2 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
351 9 1 3 4.9 CC(C)OC1=CC=CC=C1OCCNCC2=CC=CC(=C2)C3=CCCC3
CHEMBL298260 5ht1a_human Human No 8.2 EC50 = 7.1 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
433 6 1 4 4.0 C1CN(C1)C2=CC=CC(=N2)CNCC3CCN(CC3)C(=O)C4=CC(=C(C=C4)Cl)Cl
CHEMBL3805884 5ht1a_human Human No 8.1 EC50 = 7.2 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
454 8 1 5 4.9 CNC(=O)C1=C(C=CC(=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl)F
CHEMBL3805884 5ht1a_human Human No 8.1 EC50 = 7.2 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
454 8 1 5 4.9 CNC(=O)C1=C(C=CC(=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl)F
CHEMBL543377 5ht1a_human Human No 8.1 EC50 = 7.4 Funct
Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)
384 6 0 6 3.3 C1CN(CCN1CCCC(=O)C2=CC=C(C=C2)F)C3=C4C(=CC=C3)OCCO4
CHEMBL81118 5ht1a_human Human No 8.1 EC50 = 7.4 Funct
Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)
384 6 0 6 3.3 C1CN(CCN1CCCC(=O)C2=CC=C(C=C2)F)C3=C4C(=CC=C3)OCCO4
CHEMBL1774383 5ht1a_human Human No 7.1 EC50 = 71.6 Funct
Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding
463 9 1 6 4.2 COC1=CC=CC=C1N2CCN(CC2)CC(CCNC(=O)C3=CC=C(C=C3)C4=CC=CC=N4)F
CHEMBL1774383 5ht1a_human Human No 7.2 EC50 = 71.6 Funct
Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding
463 9 1 6 4.2 COC1=CC=CC=C1N2CCN(CC2)CC(CCNC(=O)C3=CC=C(C=C3)C4=CC=CC=N4)F
CHEMBL3805120 5ht1a_human Human No 7.1 EC50 = 74 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
450 8 1 4 5.1 CC1=C(C=C(C=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl)C(=O)NC
CHEMBL3805120 5ht1a_human Human No 7.1 EC50 = 74 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
450 8 1 4 5.1 CC1=C(C=C(C=C1)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl)C(=O)NC
CHEMBL2312934 5ht1a_human Human No 5.1 EC50 = 7400 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation
479 7 1 6 4.4 C1CN(CCN1CCCNS(=O)(=O)C2=CC3=C(C=CC=N3)C=C2)C4=C(C(=CC=C4)Cl)Cl
CHEMBL592028 5ht1a_human Human No 7.1 EC50 = 75 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
393 5 2 4 3.4 CN(CCCC1=CNC2=C1C=C(C=C2)F)C3CC4=C(C=CC5=C4C(=O)NC5)OC3
CHEMBL592028 5ht1a_human Human No 7.1 EC50 = 75 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
393 5 2 4 3.4 CN(CCCC1=CNC2=C1C=C(C=C2)F)C3CC4=C(C=CC5=C4C(=O)NC5)OC3
CHEMBL1645617 5ht1a_human Human No 7.1 EC50 = 77 Funct
Agonist activity at 5HT1A receptor by GTPgammaS binding assayAgonist activity at 5HT1A receptor by GTPgammaS binding assay
326 4 1 5 4.0 C1CNCC1OC2=C(C=CC=C2F)OC3=C(C=CC=C3Cl)F
CHEMBL1645617 5ht1a_human Human No 7.1 EC50 = 77 Funct
Agonist activity at 5HT1A receptor by GTPgammaS binding assayAgonist activity at 5HT1A receptor by GTPgammaS binding assay
326 4 1 5 4.0 C1CNCC1OC2=C(C=CC=C2F)OC3=C(C=CC=C3Cl)F
CHEMBL220808 5ht1a_human Human Yes 7.1 EC50 = 77.6 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
348 5 1 4 4.1 C1CC2=CC=CC=C2OC1CNCC3=CN=CC(=C3)C4=CC=C(C=C4)F
CHEMBL220808 5ht1a_human Human Yes 7.1 EC50 = 77.6 Funct
Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding
348 5 1 4 4.1 C1CC2=CC=CC=C2OC1CNCC3=CN=CC(=C3)C4=CC=C(C=C4)F
CHEMBL473902 5ht1a_human Human No 7.1 EC50 = 78 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR
364 7 2 4 4.1 CCCNC1=NC=CC(=N1)C2CCCN(C2)CCC3=CNC4=CC=CC=C43
CHEMBL1085672 5ht1a_human Human No 6.1 EC50 = 794.3 Funct
Binding affinity to 5HT1A receptorBinding affinity to 5HT1A receptor
294 3 1 2 2.2 C1CCNC(C1)CN2CCN(C2=O)C3=CC(=CC=C3)Cl
CHEMBL1085672 5ht1a_human Human No 6.1 EC50 = 794.3 Funct
Binding affinity to 5HT1A receptorBinding affinity to 5HT1A receptor
294 3 1 2 2.2 C1CCNC(C1)CN2CCN(C2=O)C3=CC(=CC=C3)Cl
CHEMBL230961 5ht1a_human Human No 5.1 EC50 = 7943.3 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
395 5 1 6 2.3 CC1=NN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL230961 5ht1a_human Human No 5.1 EC50 = 7943.3 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
395 5 1 6 2.3 CC1=NN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL56 5ht1a_human Human Yes 8.1 EC50 = 8 Funct
Agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAAgonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL3804965 5ht1a_human Human No 8.1 EC50 = 8.2 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
465 8 1 9 4.2 CNC(=O)C1=C(C=CC(=C1)OCCCCN2CCN(CC2)C3=C4C(=CC=C3)OC(O4)(F)F)F
CHEMBL3804965 5ht1a_human Human No 8.1 EC50 = 8.2 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
465 8 1 9 4.2 CNC(=O)C1=C(C=CC(=C1)OCCCCN2CCN(CC2)C3=C4C(=CC=C3)OC(O4)(F)F)F
CHEMBL46984 5ht1a_human Human No 8.1 EC50 = 8.3 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
437 7 2 6 3.9 CCNC1=C(C=CC(=N1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F)C
CHEMBL1259124 5ht1a_human Human No 8.1 EC50 = 8.6 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
408 5 0 5 3.7 CC1=CN=C(C=C1)CN(C)CC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL1259124 5ht1a_human Human No 8.1 EC50 = 8.6 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
408 5 0 5 3.7 CC1=CN=C(C=C1)CN(C)CC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL331609 5ht1a_human Human No 8.1 EC50 = 8.7 Funct
Effective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cellsEffective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cells
334 8 3 3 3.5 C1=CC=C2C(=C1)C(=CN2)CCCNCCOC3=CC=CC4=C3N=CN4
CHEMBL44659 5ht1a_human Human No 8.1 EC50 = 8.9 Funct
In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor
463 6 1 6 3.5 C1CN(CCC1(CNCC2=CC=CC(=N2)C3=CN=CO3)F)C(=O)C4=CC(=C(C=C4)Cl)Cl
CHEMBL49 5ht1a_human Human Yes 7.1 EC50 = 80 Funct
Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay
386 6 0 6 2.6 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4
CHEMBL49 5ht1a_human Human Yes 7.1 EC50 = 80 Funct
Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay
386 6 0 6 2.6 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4
CHEMBL352234 5ht1a_human Human No 7.1 EC50 = 85 Funct
Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 85-370Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 85-370
409 7 2 5 2.4 COC1=CC=CC(=C1)N2CCN(CC2)C(=O)COC3=CC4=C(C=C3)NC=C4CCN
CHEMBL394606 5ht1a_human Human No 7.1 EC50 = 85.1 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
424 6 2 7 2.9 CC1=CN=C(N=C1NC)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL394606 5ht1a_human Human No 7.1 EC50 = 85.1 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
424 6 2 7 2.9 CC1=CN=C(N=C1NC)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL3344458 5ht1a_human Human No 6.1 EC50 = 850 Funct
Agonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assay
343 4 1 4 4.4 CCCCC1=CC2=C(S1)CC3C4=CC(=C(C=C4CCN3C2)OC)O
CHEMBL3344458 5ht1a_human Human No 6.1 EC50 = 850 Funct
Agonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assay
343 4 1 4 4.4 CCCCC1=CC2=C(S1)CC3C4=CC(=C(C=C4CCN3C2)OC)O
CHEMBL391230 5ht1a_human Human No 6.1 EC50 = 854 Funct
Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as 5-HT-stimulated [35S]GTPgammaS bindingAntagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as 5-HT-stimulated [35S]GTPgammaS binding
354 7 3 3 4.5 C1C2CC3CC1CC(C2)(C3)NCCC(COC4=CC=CC5=C4C=CN5)O
CHEMBL391230 5ht1a_human Human No 6.1 EC50 = 854 Funct
Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as 5-HT-stimulated [35S]GTPgammaS bindingAntagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as 5-HT-stimulated [35S]GTPgammaS binding
354 7 3 3 4.5 C1C2CC3CC1CC(C2)(C3)NCCC(COC4=CC=CC5=C4C=CN5)O
CHEMBL597094 5ht1a_human Human No 7.1 EC50 = 86 Funct
Agonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding
291 0 0 2 3.9 CC1CC2=C(O1)C3=C(CC4C5=C3C=CC=C5CCN4C)C=C2
CHEMBL1259089 5ht1a_human Human No 7.1 EC50 = 86 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
402 5 1 5 3.9 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=C4CCCCC4=CS3)F
CHEMBL597094 5ht1a_human Human No 7.1 EC50 = 86 Funct
Agonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding
291 0 0 2 3.9 CC1CC2=C(O1)C3=C(CC4C5=C3C=CC=C5CCN4C)C=C2
CHEMBL1259089 5ht1a_human Human No 7.1 EC50 = 86 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
402 5 1 5 3.9 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=C4CCCCC4=CS3)F
CHEMBL2312637 5ht1a_human Human No 6.1 EC50 = 865 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation
493 8 1 6 4.8 C1CN(CCN1CCCCNS(=O)(=O)C2=CC3=C(C=CC=N3)C=C2)C4=C(C(=CC=C4)Cl)Cl
CHEMBL583751 5ht1a_human Human Yes 6.1 EC50 = 877 Funct
Partial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assayPartial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assay
271 3 1 3 3.7 C1CNCCC1C2=C(C(=CC=C2)F)OC3=CC=CC=C3
CHEMBL583751 5ht1a_human Human Yes 6.1 EC50 = 877 Funct
Partial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assayPartial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assay
271 3 1 3 3.7 C1CNCCC1C2=C(C(=CC=C2)F)OC3=CC=CC=C3
CHEMBL84942 5ht1a_rat Rat No 6.1 EC50 = 885 Funct
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor
337 3 2 5 3.5 CN1CCC(C1)C2=CNC3=C2C=C(C=C3)NC4=C(C=CC=N4)[N+](=O)[O-]
CHEMBL597134 5ht1a_human Human No 7.1 EC50 = 89 Funct
Agonist activity at 5HT1A receptor by GTPgammaS assayAgonist activity at 5HT1A receptor by GTPgammaS assay
307 3 1 4 3.6 C1CNCCC1C2=C(N=CC=C2)OC3=C(C=CC=C3Cl)F
CHEMBL597134 5ht1a_human Human No 7.1 EC50 = 89 Funct
Agonist activity at 5HT1A receptor by GTPgammaS assayAgonist activity at 5HT1A receptor by GTPgammaS assay
307 3 1 4 3.6 C1CNCCC1C2=C(N=CC=C2)OC3=C(C=CC=C3Cl)F
CHEMBL394778 5ht1a_human Human No 7.1 EC50 = 89.1 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
424 6 1 7 2.7 CN(C)C1=NC(=NC=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL394778 5ht1a_human Human No 7.1 EC50 = 89.1 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
424 6 1 7 2.7 CN(C)C1=NC(=NC=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F
CHEMBL3597635 5ht1a_human Human No 8.1 EC50 = 9 Funct
Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay
439 7 1 4 5.1 C1CN(CCN1CCCCNC(=O)C2=CC3=CC=CC=C3N=C2)C4=CC=CC5=CC=CC=C54
CHEMBL594788 5ht1a_human Human No 8.1 EC50 = 9 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
422 6 2 4 4.2 CCN(CCCC1=CNC2=C1C=C(C=C2)F)C3CC4=C(C=CC5=C4C(=O)NCC5)OC3
CHEMBL3597635 5ht1a_human Human No 8.1 EC50 = 9 Funct
Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay
439 7 1 4 5.1 C1CN(CCN1CCCCNC(=O)C2=CC3=CC=CC=C3N=C2)C4=CC=CC5=CC=CC=C54
CHEMBL594788 5ht1a_human Human No 8.1 EC50 = 9 Funct
Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity
422 6 2 4 4.2 CCN(CCCC1=CNC2=C1C=C(C=C2)F)C3CC4=C(C=CC5=C4C(=O)NCC5)OC3
CHEMBL126536 5ht1a_human Human No 8.0 EC50 = 9.1 Funct
Effective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cellsEffective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cells
363 8 2 4 4.3 C1=CC2=C(C=CC=N2)C(=C1)OCCNCCCC3=CNC4=C3C=C(C=C4)F
CHEMBL206644 5ht1a_human Human No 7.1 EC50 = 90 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
353 6 2 4 4.0 CCN1CC(OC2=CC=CC=C21)CNCCC3=CNC4=C3C=C(C=C4)F
CHEMBL206644 5ht1a_human Human No 7.1 EC50 = 90 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
353 6 2 4 4.0 CCN1CC(OC2=CC=CC=C21)CNCCC3=CNC4=C3C=C(C=C4)F
CHEMBL480663 5ht1a_human Human No 5.1 EC50 = 9000 Funct
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cellsDisplacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells
325 1 1 5 2.8 CN1C2CC3=CC4=C(C=C3C1CC5=CC(=C(C=C25)O)OC)OCO4
CHEMBL480663 5ht1a_human Human No 5.1 EC50 = 9000 Funct
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cellsDisplacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells
325 1 1 5 2.8 CN1C2CC3=CC4=C(C=C3C1CC5=CC(=C(C=C25)O)OC)OCO4
CHEMBL1259035 5ht1a_human Human No 7.0 EC50 = 93 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
381 5 1 5 2.0 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=NN4C=CC=CC4=C3)F
CHEMBL1259035 5ht1a_human Human No 7.0 EC50 = 93 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
381 5 1 5 2.0 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=NN4C=CC=CC4=C3)F
CHEMBL209821 5ht1a_human Human Yes 7.0 EC50 = 93.3 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
451 10 2 6 3.2 CC(=O)NC1=CC=CC(=C1)N2CCN(CC2)CCCCNS(=O)(=O)CC3CCCCC3
CHEMBL209821 5ht1a_human Human Yes 7.0 EC50 = 93.3 Funct
Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
451 10 2 6 3.2 CC(=O)NC1=CC=CC(=C1)N2CCN(CC2)CCCCNS(=O)(=O)CC3CCCCC3
CHEMBL380342 5ht1a_human Human No 7.0 EC50 = 93.5 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
307 5 3 3 3.4 C1C(OC2=CC=CC=C2N1)CNCCC3=CNC4=CC=CC=C43
CHEMBL380342 5ht1a_human Human No 7.0 EC50 = 93.5 Funct
Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor
307 5 3 3 3.4 C1C(OC2=CC=CC=C2N1)CNCCC3=CNC4=CC=CC=C43
CHEMBL160581 5ht1a_human Human No 7.0 EC50 = 95 Funct
Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1A receptor in HeLa cells; value ranges from 95-320Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1A receptor in HeLa cells; value ranges from 95-320
429 6 2 4 3.7 C1CN(CCN1C2=CC=CC3=CC=CC=C32)C(=O)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL3806047 5ht1a_human Human No 7.0 EC50 = 97.2 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
450 8 1 4 5.1 CC1=CC(=CC(=C1)C(=O)NC)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
CHEMBL3806047 5ht1a_human Human No 7.0 EC50 = 97.2 Funct
Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay
450 8 1 4 5.1 CC1=CC(=CC(=C1)C(=O)NC)OCCCCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
CHEMBL2112644 5ht1a_human Human No 7.0 EC50 = 97.4 Funct
Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor
312 8 2 3 4.0 C1=CC=C(C=C1)OCCNCCCC2=CNC3=C2C=C(C=C3)F
CHEMBL1259165 5ht1a_human Human No 7.0 EC50 = 99 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
377 6 1 6 2.1 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CSC=C3OC)F
CHEMBL1259165 5ht1a_human Human No 7.0 EC50 = 99 Funct
Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding
377 6 1 6 2.1 CC1=CN=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CSC=C3OC)F
CHEMBL186423 5ht1a_rat Rat No 11.0 IC50 = 0.0 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
420 7 2 5 3.3 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C(=O)N)C4=C(C(=CC=C4)F)C#N
CHEMBL186423 5ht1a_rat Rat No 11.0 IC50 = 0.0 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
420 7 2 5 3.3 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C(=O)N)C4=C(C(=CC=C4)F)C#N
CHEMBL364181 5ht1a_rat Rat No 10.2 IC50 = 0.1 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
437 9 2 5 3.5 COC1=CC(=C(C=C1)N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)C(=O)N)OC
CHEMBL364181 5ht1a_rat Rat No 10.2 IC50 = 0.1 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
437 9 2 5 3.5 COC1=CC(=C(C=C1)N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)C(=O)N)OC
CHEMBL360419 5ht1a_rat Rat No 10.1 IC50 = 0.1 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
407 8 2 4 3.5 COC1=CC=C(C=C1)N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)C(=O)N
CHEMBL286725 5ht1a_rat Rat Yes 10.1 IC50 = 0.1 Funct
Binding affinity was measured at the serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand in rat hippocampal membrane.Binding affinity was measured at the serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand in rat hippocampal membrane.
369 7 1 5 2.8 COC1=CC=CC(=C1)C(=O)NCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL360419 5ht1a_rat Rat No 10.1 IC50 = 0.1 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
407 8 2 4 3.5 COC1=CC=C(C=C1)N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)C(=O)N
CHEMBL365716 5ht1a_rat Rat No 10.0 IC50 = 0.1 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
377 7 2 3 3.5 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C(=O)N)C4=CC=CC=C4
CHEMBL185860 5ht1a_rat Rat No 10.0 IC50 = 0.1 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
407 8 2 4 3.5 COC1=CC=CC=C1N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)C(=O)N
CHEMBL189708 5ht1a_rat Rat No 10.0 IC50 = 0.1 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
434 8 3 4 2.7 CC(=O)NC1=CC=C(C=C1)N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)C(=O)N
CHEMBL188625 5ht1a_rat Rat No 10.0 IC50 = 0.1 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
376 7 2 2 4.2 C1CN(CCC1C2=CC=CC=C2)CCCCC3=CNC4=C3C=C(C=C4)C(=O)N
CHEMBL189704 5ht1a_rat Rat No 10.0 IC50 = 0.1 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
427 6 1 5 4.4 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=O)C=C5
CHEMBL365716 5ht1a_rat Rat No 10.0 IC50 = 0.1 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
377 7 2 3 3.5 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C(=O)N)C4=CC=CC=C4
CHEMBL185860 5ht1a_rat Rat No 10.0 IC50 = 0.1 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
407 8 2 4 3.5 COC1=CC=CC=C1N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)C(=O)N
CHEMBL189708 5ht1a_rat Rat No 10.0 IC50 = 0.1 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
434 8 3 4 2.7 CC(=O)NC1=CC=C(C=C1)N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)C(=O)N
CHEMBL188625 5ht1a_rat Rat No 10.0 IC50 = 0.1 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
376 7 2 2 4.2 C1CN(CCC1C2=CC=CC=C2)CCCCC3=CNC4=C3C=C(C=C4)C(=O)N
CHEMBL189704 5ht1a_rat Rat No 10.0 IC50 = 0.1 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
427 6 1 5 4.4 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=O)C=C5
CHEMBL416523 5ht1a_human Human No 9.9 IC50 = 0.1 Funct
Binding affinity towards 5-hydroxytryptamine 1A receptor by displacement of [3H]8-OH-DPAT.Binding affinity towards 5-hydroxytryptamine 1A receptor by displacement of [3H]8-OH-DPAT.
415 8 1 5 3.4 COC1=CC=CC2=C1CC(CO2)CNCCCCN3C(=O)CC4(CCCC4)CC3=O
CHEMBL22960 5ht1a_rat Rat No 9.9 IC50 = 0.1 Funct
Inhibitory activity against 5-hydroxytryptamine 1A receptor subtypeInhibitory activity against 5-hydroxytryptamine 1A receptor subtype
677 19 6 4 7.6 C1CC(=CCC1NCCCCCCCCCCCCNC2CCC(=CC2)C3=CNC4=C3C=C(C=C4)C(=O)N)C5=CNC6=C5C=C(C=C6)C(=O)N
CHEMBL290937 5ht1a_rat Rat No 9.7 IC50 = 0.2 Funct
Inhibition of [3H]8-OH-DPAT binding at serotonin 5-hydroxytryptamine 1A receptor from rat hippocampus tissue.Inhibition of [3H]8-OH-DPAT binding at serotonin 5-hydroxytryptamine 1A receptor from rat hippocampus tissue.
421 6 0 6 4.0 C1CN(CCN1CCCCN2C(=O)C3=CC=CC=C3C2=O)C4=NSC5=CC=CC=C54
CHEMBL290937 5ht1a_rat Rat No 9.7 IC50 = 0.2 Funct
In vitro binding affinity was measured on serotonergic 5-hydroxytryptamine 1A receptor by displacement of [3H]- tetralinIn vitro binding affinity was measured on serotonergic 5-hydroxytryptamine 1A receptor by displacement of [3H]- tetralin
421 6 0 6 4.0 C1CN(CCN1CCCCN2C(=O)C3=CC=CC=C3C2=O)C4=NSC5=CC=CC=C54
CHEMBL290937 5ht1a_rat Rat No 9.7 IC50 = 0.2 Funct
Inhibition of [3H]8-OH-DPAT binding at serotonin 5-hydroxytryptamine 1A receptor from rat hippocampus tissue.Inhibition of [3H]8-OH-DPAT binding at serotonin 5-hydroxytryptamine 1A receptor from rat hippocampus tissue.
421 6 0 6 4.0 C1CN(CCN1CCCCN2C(=O)C3=CC=CC=C3C2=O)C4=NSC5=CC=CC=C54
CHEMBL189450 5ht1a_rat Rat No 9.7 IC50 = 0.2 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
402 7 2 4 3.2 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C(=O)N)C4=CC=CC=C4C#N
CHEMBL364592 5ht1a_rat Rat No 9.7 IC50 = 0.2 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
435 7 2 5 3.2 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C(=O)N)C4=CC5=C(C=C4)OCCO5
CHEMBL439664 5ht1a_rat Rat No 9.7 IC50 = 0.2 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
393 7 3 4 3.2 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C(=O)N)C4=CC=C(C=C4)O
CHEMBL363055 5ht1a_rat Rat No 9.7 IC50 = 0.2 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
408 6 2 5 4.0 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)O)C4=CC5=C(C=C4)OCCO5
CHEMBL364592 5ht1a_rat Rat No 9.7 IC50 = 0.2 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
435 7 2 5 3.2 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C(=O)N)C4=CC5=C(C=C4)OCCO5
CHEMBL304438 5ht1a_human Human No 9.7 IC50 = 0.2 Funct
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPATAffinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPAT
381 5 0 5 2.9 CN1C(=O)COC2=C1C=CC(=C2)CCN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL64878 5ht1a_human Human No 9.7 IC50 = 0.2 Funct
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPATAffinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPAT
398 7 1 5 4.3 COC1=CC=CC=C1N2CCN(CC2)CCCCC3=CC4=C(C=C3)NC(=O)S4
CHEMBL60447 5ht1a_human Human No 9.7 IC50 = 0.2 Funct
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPATAffinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPAT
369 4 1 5 3.4 CN1C2=C(C=C(C=C2)CCN3CCN(CC3)C4=CC=CC=C4O)SC1=O
CHEMBL11592 5ht1a_human Human Yes 9.7 IC50 = 0.2 Funct
Binding affinity towards 5-hydroxytryptamine 1A receptor by displacement of [3H]8-OH-DPAT.Binding affinity towards 5-hydroxytryptamine 1A receptor by displacement of [3H]8-OH-DPAT.
443 9 0 5 4.6 CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL189450 5ht1a_rat Rat No 9.7 IC50 = 0.2 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
402 7 2 4 3.2 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C(=O)N)C4=CC=CC=C4C#N
CHEMBL364592 5ht1a_rat Rat No 9.7 IC50 = 0.2 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
435 7 2 5 3.2 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C(=O)N)C4=CC5=C(C=C4)OCCO5
CHEMBL439664 5ht1a_rat Rat No 9.7 IC50 = 0.2 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
393 7 3 4 3.2 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C(=O)N)C4=CC=C(C=C4)O
CHEMBL363055 5ht1a_rat Rat No 9.7 IC50 = 0.2 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
408 6 2 5 4.0 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)O)C4=CC5=C(C=C4)OCCO5
CHEMBL364592 5ht1a_rat Rat No 9.7 IC50 = 0.2 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
435 7 2 5 3.2 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C(=O)N)C4=CC5=C(C=C4)OCCO5
CHEMBL281575 5ht1a_rat Rat No 9.7 IC50 = 0.2 Funct
Inhibitory activity against 5-hydroxytryptamine 1A receptor subtypeInhibitory activity against 5-hydroxytryptamine 1A receptor subtype
649 17 6 4 6.5 C1CC(=CCC1NCCCCCCCCCCNC2CCC(=CC2)C3=CNC4=C3C=C(C=C4)C(=O)N)C5=CNC6=C5C=C(C=C6)C(=O)N
CHEMBL186608 5ht1a_rat Rat No 9.5 IC50 = 0.3 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
420 8 3 4 2.4 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C(=O)N)C4=CC=CC=C4C(=O)N
CHEMBL439849 5ht1a_rat Rat Yes 9.5 IC50 = 0.3 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
442 7 2 5 4.0 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
CHEMBL60885 5ht1a_human Human No 9.5 IC50 = 0.3 Funct
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPATAffinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPAT
369 5 1 5 3.5 COC1=CC=CC=C1N2CCN(CC2)CCC3=CC4=C(C=C3)NC(=O)S4
CHEMBL12028 5ht1a_rat Rat No 9.5 IC50 = 0.3 Funct
In vitro inhibitory concentration against radioligand [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat hippocampal membrane.In vitro inhibitory concentration against radioligand [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat hippocampal membrane.
460 7 1 8 3.8 CC1=C(SC2=C1C(=O)N(C(=N2)SCCCN3CCN(CC3)C4=CC=CC=C4OC)N)C
CHEMBL186608 5ht1a_rat Rat No 9.5 IC50 = 0.3 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
420 8 3 4 2.4 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C(=O)N)C4=CC=CC=C4C(=O)N
CHEMBL439849 5ht1a_rat Rat Yes 9.5 IC50 = 0.3 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
442 7 2 5 4.0 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
CHEMBL26929 5ht1a_rat Rat No 9.5 IC50 = 0.3 Funct
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.
395 7 0 4 5.4 COC1=CC=CC=C1N2CCN(CC2)CCCC3CCCC4=C3C=CC=C4OC
CHEMBL140406 5ht1a_rat Rat No 9.5 IC50 = 0.4 Funct
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.
364 5 0 4 4.2 COC1=CC=CC2=C1CCCC2=CCCN3CCN(CC3)C4=CC=CC=N4
CHEMBL322275 5ht1a_rat Rat No 9.4 IC50 = 0.4 Funct
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.
365 6 0 3 5.4 COC1=CC=CC2=C1CCCC2CCCN3CCN(CC3)C4=CC=CC=C4
CHEMBL368477 5ht1a_rat Rat No 9.4 IC50 = 0.4 Funct
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.
365 6 0 3 5.4 COC1=CC=CC=C1N2CCN(CC2)CCCC3CCCC4=CC=CC=C34
CHEMBL89007 5ht1a_human Human No 9.4 IC50 = 0.4 Funct
Ability to bind to 5-hydroxytryptamine 1A receptor from cloned human expressed in Ha7 cellsAbility to bind to 5-hydroxytryptamine 1A receptor from cloned human expressed in Ha7 cells
333 7 2 5 3.7 C1CC2=CC=CC=C2OC1CNCCCNC3=NN=C(C=C3)Cl
CHEMBL189454 5ht1a_rat Rat No 9.4 IC50 = 0.4 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
406 7 1 4 4.6 COC1=CC2=C(C=C1)NC=C2CCCCN3CCN(CC3)C4=CC5=C(C=C4)OCC5
CHEMBL186405 5ht1a_rat Rat No 9.4 IC50 = 0.4 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
377 7 2 3 4.5 COC1=CC2=C(C=C1)NC=C2CCCCN3CCC(=CC3)C4=CC=C(C=C4)O
CHEMBL186814 5ht1a_rat Rat No 9.4 IC50 = 0.4 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
405 7 1 4 4.7 COC1=CC2=C(C=C1)NC=C2CCCCN3CCC(=CC3)C4=CC5=C(C=C4)OCO5
CHEMBL363537 5ht1a_rat Rat No 9.4 IC50 = 0.4 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
421 7 2 5 3.3 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C(=O)N)C4=CC5=C(C=C4)OCO5
CHEMBL184556 5ht1a_rat Rat No 9.4 IC50 = 0.4 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
424 6 1 5 4.8 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C#N
CHEMBL185730 5ht1a_rat Rat No 9.4 IC50 = 0.4 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
435 7 2 6 4.1 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C=NO)C4=CC5=C(C=C4)OCCO5
CHEMBL27991 5ht1a_rat Rat No 9.4 IC50 = 0.4 Funct
Binding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranesBinding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranes
415 10 1 5 4.7 CCCN(CCCCNC(=O)C1=CC=C(C=C1)F)C2CC3=C(C=CC=C3OC)OC2
CHEMBL298534 5ht1a_rat Rat No 9.4 IC50 = 0.4 Funct
Binding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranesBinding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranes
415 10 1 5 4.7 CCCN(CCCCNC(=O)C1=CC=C(C=C1)F)C2CC3=C(C=CC=C3OC)OC2
CHEMBL87294 5ht1a_rat Rat No 9.4 IC50 = 0.4 Funct
In vitro binding affinity was measured on serotonergic 5-hydroxytryptamine 1A receptor by displacement of [3H]- tetralinIn vitro binding affinity was measured on serotonergic 5-hydroxytryptamine 1A receptor by displacement of [3H]- tetralin
457 6 0 7 3.7 C1CN(CCN1CCCCN2C(=O)C3=CC=CC=C3S2(=O)=O)C4=NSC5=CC=CC=C54
CHEMBL189454 5ht1a_rat Rat No 9.4 IC50 = 0.4 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
406 7 1 4 4.6 COC1=CC2=C(C=C1)NC=C2CCCCN3CCN(CC3)C4=CC5=C(C=C4)OCC5
CHEMBL186405 5ht1a_rat Rat No 9.4 IC50 = 0.4 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
377 7 2 3 4.5 COC1=CC2=C(C=C1)NC=C2CCCCN3CCC(=CC3)C4=CC=C(C=C4)O
CHEMBL186814 5ht1a_rat Rat No 9.4 IC50 = 0.4 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
405 7 1 4 4.7 COC1=CC2=C(C=C1)NC=C2CCCCN3CCC(=CC3)C4=CC5=C(C=C4)OCO5
CHEMBL363537 5ht1a_rat Rat No 9.4 IC50 = 0.4 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
421 7 2 5 3.3 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C(=O)N)C4=CC5=C(C=C4)OCO5
CHEMBL184556 5ht1a_rat Rat No 9.4 IC50 = 0.4 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
424 6 1 5 4.8 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C#N
CHEMBL185730 5ht1a_rat Rat No 9.4 IC50 = 0.4 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
435 7 2 6 4.1 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C=NO)C4=CC5=C(C=C4)OCCO5
CHEMBL345237 5ht1a_rat Rat Yes 9.3 IC50 = 0.5 Funct
Binding affinity to 5-hydroxytryptamine 1A receptor of rat hippocampus with [3H]8-OH-DPAT as radioligandBinding affinity to 5-hydroxytryptamine 1A receptor of rat hippocampus with [3H]8-OH-DPAT as radioligand
410 6 0 4 3.6 C1CN(CC=C1C2=CC=CC=N2)CCCCN3C(=COC4=CC=CC=C4C3=O)Cl
CHEMBL186115 5ht1a_rat Rat No 9.3 IC50 = 0.5 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
422 9 1 5 4.4 CC(=O)OC1=CC2=C(C=C1)NC=C2CCCCN3CCN(CC3)C4=CC=C(C=C4)OC
CHEMBL188296 5ht1a_rat Rat No 9.3 IC50 = 0.5 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
422 7 1 5 4.3 COC1=CC2=C(C=C1)NC=C2CCCCN3CCN(CC3)C4=CC5=C(C=C4)OCCO5
CHEMBL185915 5ht1a_rat Rat No 9.3 IC50 = 0.5 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
433 7 2 4 3.9 C1CC2=C(C=CC(=C2)N3CCN(CC3)CCCCC4=CNC5=C4C=C(C=C5)C(=O)N)OC1
CHEMBL363292 5ht1a_rat Rat Yes 9.3 IC50 = 0.5 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
419 7 2 4 3.5 C1COC2=C1C=C(C=C2)N3CCN(CC3)CCCCC4=CNC5=C4C=C(C=C5)C(=O)N
CHEMBL188296 5ht1a_rat Rat No 9.3 IC50 = 0.5 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
422 7 1 5 4.3 COC1=CC2=C(C=C1)NC=C2CCCCN3CCN(CC3)C4=CC5=C(C=C4)OCCO5
CHEMBL322275 5ht1a_rat Rat No 9.3 IC50 = 0.5 Funct
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligandBinding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand
365 6 0 3 5.4 COC1=CC=CC2=C1CCCC2CCCN3CCN(CC3)C4=CC=CC=C4
CHEMBL322275 5ht1a_rat Rat No 9.3 IC50 = 0.5 Funct
Binding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligandBinding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligand
365 6 0 3 5.4 COC1=CC=CC2=C1CCCC2CCCN3CCN(CC3)C4=CC=CC=C4
CHEMBL322275 5ht1a_rat Rat No 9.3 IC50 = 0.5 Funct
In vitro inhibition of [3H]8-OH-DPAT binding to rat 5-HT 1a receptors.In vitro inhibition of [3H]8-OH-DPAT binding to rat 5-HT 1a receptors.
365 6 0 3 5.4 COC1=CC=CC2=C1CCCC2CCCN3CCN(CC3)C4=CC=CC=C4
CHEMBL347623 5ht1a_rat Rat No 9.3 IC50 = 0.5 Funct
In vitro inhibitory concentration against radioligand [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat hippocampal membrane.In vitro inhibitory concentration against radioligand [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat hippocampal membrane.
426 7 1 7 3.0 COC1=CC=CC=C1N2CCN(CC2)CCCSC3=NC4=CC=CC=C4C(=O)N3N
CHEMBL186115 5ht1a_rat Rat No 9.3 IC50 = 0.5 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
422 9 1 5 4.4 CC(=O)OC1=CC2=C(C=C1)NC=C2CCCCN3CCN(CC3)C4=CC=C(C=C4)OC
CHEMBL188296 5ht1a_rat Rat No 9.3 IC50 = 0.5 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
422 7 1 5 4.3 COC1=CC2=C(C=C1)NC=C2CCCCN3CCN(CC3)C4=CC5=C(C=C4)OCCO5
CHEMBL185915 5ht1a_rat Rat No 9.3 IC50 = 0.5 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
433 7 2 4 3.9 C1CC2=C(C=CC(=C2)N3CCN(CC3)CCCCC4=CNC5=C4C=C(C=C5)C(=O)N)OC1
CHEMBL363292 5ht1a_rat Rat Yes 9.3 IC50 = 0.5 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
419 7 2 4 3.5 C1COC2=C1C=C(C=C2)N3CCN(CC3)CCCCC4=CNC5=C4C=C(C=C5)C(=O)N
CHEMBL188296 5ht1a_rat Rat No 9.3 IC50 = 0.5 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
422 7 1 5 4.3 COC1=CC2=C(C=C1)NC=C2CCCCN3CCN(CC3)C4=CC5=C(C=C4)OCCO5
CHEMBL56 5ht1a_human Human Yes 9.3 IC50 = 0.5 Funct
Binding affinity to human 5-HT1A receptor by radioligand displacement assayBinding affinity to human 5-HT1A receptor by radioligand displacement assay
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL173190 5ht1a_rat Rat No 9.3 IC50 = 0.5 Funct
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.
393 6 0 4 4.9 COC1=CC=CC=C1N2CCN(CC2)CCC=C3CCCC4=C3C=CC=C4OC
CHEMBL56 5ht1a_human Human Yes 9.3 IC50 = 0.5 Funct
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL56 5ht1a_human Human Yes 9.3 IC50 = 0.5 Funct
Displacement of [3H]8-OHDPAT from human recombinant 5-HT1A receptor expressed in HEK293 cellsDisplacement of [3H]8-OHDPAT from human recombinant 5-HT1A receptor expressed in HEK293 cells
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL56 5ht1a_human Human Yes 9.3 IC50 = 0.5 Funct
Displacement of [3H]8-OHDPAT from human recombinant 5-HT1A receptor expressed in HEK293 cellsDisplacement of [3H]8-OHDPAT from human recombinant 5-HT1A receptor expressed in HEK293 cells
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL444590 5ht1a_rat Rat No 9.3 IC50 = 0.5 Funct
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligandBinding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand
366 6 0 4 4.7 COC1=CC=CC2=C1CCCC2CCCN3CCN(CC3)C4=CC=CC=N4
CHEMBL444590 5ht1a_rat Rat No 9.3 IC50 = 0.5 Funct
Binding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligandBinding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligand
366 6 0 4 4.7 COC1=CC=CC2=C1CCCC2CCCN3CCN(CC3)C4=CC=CC=N4
CHEMBL444590 5ht1a_rat Rat No 9.3 IC50 = 0.5 Funct
In vitro inhibition of [3H]8-OH-DPAT binding to rat 5-HT 1a receptors.In vitro inhibition of [3H]8-OH-DPAT binding to rat 5-HT 1a receptors.
366 6 0 4 4.7 COC1=CC=CC2=C1CCCC2CCCN3CCN(CC3)C4=CC=CC=N4
CHEMBL444590 5ht1a_rat Rat No 9.2 IC50 = 0.6 Funct
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.
366 6 0 4 4.7 COC1=CC=CC2=C1CCCC2CCCN3CCN(CC3)C4=CC=CC=N4
CHEMBL56 5ht1a_human Human Yes 9.2 IC50 = 0.6 Funct
Inhibition of human 5HT1A receptorInhibition of human 5HT1A receptor
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL314370 5ht1a_rat Rat No 9.2 IC50 = 0.6 Funct
In vitro binding affinity was measured on serotonergic 5-hydroxytryptamine 1A receptor by displacement of [3H]- tetralinIn vitro binding affinity was measured on serotonergic 5-hydroxytryptamine 1A receptor by displacement of [3H]- tetralin
420 6 0 6 4.0 C1CN(CCN1CCCCN2C=NC3=CC=CC=C3C2=O)C4=NSC5=CC=CC=C54
CHEMBL56 5ht1a_human Human Yes 9.2 IC50 = 0.6 Funct
Inhibition of human 5HT1A receptorInhibition of human 5HT1A receptor
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL366104 5ht1a_rat Rat No 9.2 IC50 = 0.6 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
391 8 1 3 4.9 COC1=CC=C(C=C1)C2=CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)OC
CHEMBL188848 5ht1a_rat Rat No 9.2 IC50 = 0.6 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
450 8 1 6 4.2 COC(=O)C1=CC2=C(C=C1)NC=C2CCCCN3CCN(CC3)C4=CC5=C(C=C4)OCCO5
CHEMBL64610 5ht1a_human Human No 9.2 IC50 = 0.6 Funct
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPATAffinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPAT
448 6 0 7 4.5 CN1C(=O)COC2=C1C=CC(=C2)CCCCN3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F
CHEMBL366104 5ht1a_rat Rat No 9.2 IC50 = 0.6 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
391 8 1 3 4.9 COC1=CC=C(C=C1)C2=CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)OC
CHEMBL188848 5ht1a_rat Rat No 9.2 IC50 = 0.6 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
450 8 1 6 4.2 COC(=O)C1=CC2=C(C=C1)NC=C2CCCCN3CCN(CC3)C4=CC5=C(C=C4)OCCO5
CHEMBL12129 5ht1a_rat Rat Yes 9.2 IC50 = 0.6 Funct
Binding affinity towards 5-hydroxytryptamine 1A receptor in rat frontal cortex using [3H]8-OH-DPAT as a radioligandBinding affinity towards 5-hydroxytryptamine 1A receptor in rat frontal cortex using [3H]8-OH-DPAT as a radioligand
386 7 1 5 3.0 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCNCC3COC4=CC=CC=C4O3
CHEMBL86013 5ht1a_rat Rat No 9.2 IC50 = 0.6 Funct
In vitro binding affinity was measured on serotonergic 5-hydroxytryptamine 1A receptor by displacement of [3H]- tetralinIn vitro binding affinity was measured on serotonergic 5-hydroxytryptamine 1A receptor by displacement of [3H]- tetralin
421 6 0 5 4.5 C1CN(C(=O)C2=CC=CC=C21)CCCCN3CCN(CC3)C4=NSC5=CC=CC=C54
CHEMBL56 5ht1a_human Human Yes 9.2 IC50 = 0.7 Funct
Percent inhibition against 5-hydroxytryptamine 1A receptor at 1 uMPercent inhibition against 5-hydroxytryptamine 1A receptor at 1 uM
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL366269 5ht1a_rat Rat No 9.2 IC50 = 0.7 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
475 8 2 4 4.8 COC1=C(C=C(C=C1Cl)N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)C(=O)N)Cl
CHEMBL188799 5ht1a_rat Rat No 9.2 IC50 = 0.7 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
402 6 1 5 4.2 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OCO5
CHEMBL278471 5ht1a_rat Rat No 9.2 IC50 = 0.7 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
420 6 1 5 4.7 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)F)C4=CC5=C(C=C4)OC(=O)C=C5
CHEMBL185768 5ht1a_rat Rat No 9.2 IC50 = 0.7 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
420 7 1 5 3.8 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C=O)C4=CC5=C(C=C4)OCCO5
CHEMBL60047 5ht1a_human Human No 9.2 IC50 = 0.7 Funct
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPATAffinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPAT
419 4 0 7 3.8 CN1C(=O)COC2=C1C=CC(=C2)CCN3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F
CHEMBL64167 5ht1a_human Human No 9.2 IC50 = 0.7 Funct
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPATAffinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPAT
353 4 0 4 3.8 CN1C2=C(C=C(C=C2)CCN3CCN(CC3)C4=CC=CC=C4)SC1=O
CHEMBL61869 5ht1a_human Human No 9.2 IC50 = 0.7 Funct
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPATAffinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPAT
355 4 2 5 3.2 C1CN(CCN1CCC2=CC3=C(C=C2)NC(=O)S3)C4=CC=CC=C4O
CHEMBL366269 5ht1a_rat Rat No 9.2 IC50 = 0.7 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
475 8 2 4 4.8 COC1=C(C=C(C=C1Cl)N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)C(=O)N)Cl
CHEMBL188799 5ht1a_rat Rat No 9.2 IC50 = 0.7 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
402 6 1 5 4.2 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OCO5
CHEMBL278471 5ht1a_rat Rat No 9.2 IC50 = 0.7 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
420 6 1 5 4.7 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)F)C4=CC5=C(C=C4)OC(=O)C=C5
CHEMBL185768 5ht1a_rat Rat No 9.2 IC50 = 0.7 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
420 7 1 5 3.8 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C=O)C4=CC5=C(C=C4)OCCO5
CHEMBL319132 5ht1a_rat Rat No 9.1 IC50 = 0.8 Funct
Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheInhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal raphe
443 5 1 7 3.4 COC1=CC(=C(C=C1)F)CN2CCN(CC2)C3CCC(CC3)(C4=CC5=C(C=C4)OCO5)O
CHEMBL38409 5ht1a_rat Rat No 9.1 IC50 = 0.8 Funct
Inhibition of [3H]8-OH-DPAT binding at serotonin 5-hydroxytryptamine 1A receptor from rat hippocampus tissue.Inhibition of [3H]8-OH-DPAT binding at serotonin 5-hydroxytryptamine 1A receptor from rat hippocampus tissue.
449 8 0 6 4.7 C1CN(CCN1CCCCCCN2C(=O)C3=CC=CC=C3C2=O)C4=NSC5=CC=CC=C54
CHEMBL38409 5ht1a_rat Rat No 9.1 IC50 = 0.8 Funct
Inhibition of [3H]8-OH-DPAT binding at serotonin 5-hydroxytryptamine 1A receptor from rat hippocampus tissue.Inhibition of [3H]8-OH-DPAT binding at serotonin 5-hydroxytryptamine 1A receptor from rat hippocampus tissue.
449 8 0 6 4.7 C1CN(CCN1CCCCCCN2C(=O)C3=CC=CC=C3C2=O)C4=NSC5=CC=CC=C54
CHEMBL423361 5ht1a_human Human Yes 9.1 IC50 = 0.8 Funct
Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HEK293 EBNA cells after 2 hrs by liquid scintillation countingDisplacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HEK293 EBNA cells after 2 hrs by liquid scintillation counting
409 6 1 5 3.9 C1CCC(CC1)C(=O)N(CCN2CCN(CC2)C3=CC=CC=C3O)C4=CC=CC=N4
CHEMBL423361 5ht1a_human Human Yes 9.1 IC50 = 0.8 Funct
Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in HEK293 EBNA cells after 1 hr by liquid scintillation countingDisplacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in HEK293 EBNA cells after 1 hr by liquid scintillation counting
409 6 1 5 3.9 C1CCC(CC1)C(=O)N(CCN2CCN(CC2)C3=CC=CC=C3O)C4=CC=CC=N4
CHEMBL357266 5ht1a_rat Rat No 9.1 IC50 = 0.8 Funct
Inhibitory concentration against 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]-8-OH-DPAT as radioligandInhibitory concentration against 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]-8-OH-DPAT as radioligand
413 6 0 5 3.6 C1CN(CCN1CCCCN2C(=COC3=CC=CC=C3C2=O)Cl)C4=CC=CC=N4
CHEMBL26929 5ht1a_rat Rat No 9.1 IC50 = 0.8 Funct
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligandBinding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand
395 7 0 4 5.4 COC1=CC=CC=C1N2CCN(CC2)CCCC3CCCC4=C3C=CC=C4OC
CHEMBL357266 5ht1a_rat Rat No 9.1 IC50 = 0.8 Funct
Binding affinity to 5-hydroxytryptamine 1A receptor of rat hippocampus with [3H]8-OH-DPAT as radioligandBinding affinity to 5-hydroxytryptamine 1A receptor of rat hippocampus with [3H]8-OH-DPAT as radioligand
413 6 0 5 3.6 C1CN(CCN1CCCCN2C(=COC3=CC=CC=C3C2=O)Cl)C4=CC=CC=N4
CHEMBL26929 5ht1a_rat Rat No 9.1 IC50 = 0.8 Funct
Binding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligandBinding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligand
395 7 0 4 5.4 COC1=CC=CC=C1N2CCN(CC2)CCCC3CCCC4=C3C=CC=C4OC
CHEMBL26929 5ht1a_rat Rat No 9.1 IC50 = 0.8 Funct
In vitro inhibition of [3H]8-OH-DPAT binding to rat 5-HT 1a receptors.In vitro inhibition of [3H]8-OH-DPAT binding to rat 5-HT 1a receptors.
395 7 0 4 5.4 COC1=CC=CC=C1N2CCN(CC2)CCCC3CCCC4=C3C=CC=C4OC
CHEMBL357266 5ht1a_rat Rat No 9.1 IC50 = 0.8 Funct
Inhibitory concentration against 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]-8-OH-DPAT as radioligandInhibitory concentration against 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]-8-OH-DPAT as radioligand
413 6 0 5 3.6 C1CN(CCN1CCCCN2C(=COC3=CC=CC=C3C2=O)Cl)C4=CC=CC=N4
CHEMBL12152 5ht1a_rat Rat Yes 9.1 IC50 = 0.8 Funct
Binding affinity towards 5-hydroxytryptamine 1A receptor in rat frontal cortex using [3H]8-OH-DPAT as a radioligandBinding affinity towards 5-hydroxytryptamine 1A receptor in rat frontal cortex using [3H]8-OH-DPAT as a radioligand
386 7 1 5 3.0 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCNCC3COC4=CC=CC=C4O3
CHEMBL431367 5ht1a_human Human Yes 9.1 IC50 = 0.8 Funct
Inhibition of 5HT1A receptorInhibition of 5HT1A receptor
346 6 2 2 4.6 C1CN(CC=C1C2=CC=CC=C2)CCCCC3=CNC4=C3C=C(C=C4)O
CHEMBL188471 5ht1a_rat Rat No 9.1 IC50 = 0.8 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
408 9 1 4 5.0 CCOC1=CC=C(C=C1)N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)OC
CHEMBL362771 5ht1a_rat Rat No 9.1 IC50 = 0.8 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
349 6 2 3 3.5 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)O)C4=CC=CC=C4
CHEMBL431367 5ht1a_rat Rat Yes 9.1 IC50 = 0.8 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
346 6 2 2 4.6 C1CN(CC=C1C2=CC=CC=C2)CCCCC3=CNC4=C3C=C(C=C4)O
CHEMBL59823 5ht1a_human Human No 9.1 IC50 = 0.8 Funct
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPATAffinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPAT
410 7 0 5 3.6 CN1C(=O)COC2=C1C=CC(=C2)CCCCN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL61819 5ht1a_human Human No 9.1 IC50 = 0.8 Funct
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPATAffinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPAT
412 7 0 5 4.4 CN1C2=C(C=C(C=C2)CCCCN3CCN(CC3)C4=CC=CC=C4OC)SC1=O
CHEMBL154787 5ht1a_rat Rat No 9.1 IC50 = 0.8 Funct
In vitro inhibitory concentration against radioligand [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat hippocampal membrane.In vitro inhibitory concentration against radioligand [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat hippocampal membrane.
459 7 1 7 4.5 CC1=C(SC2=C1C(=O)N(C(=N2)SCCCN3CCC(CC3)C4=CC=CC=C4OC)N)C
CHEMBL431367 5ht1a_human Human Yes 9.1 IC50 = 0.8 Funct
Inhibition of 5HT1A receptorInhibition of 5HT1A receptor
346 6 2 2 4.6 C1CN(CC=C1C2=CC=CC=C2)CCCCC3=CNC4=C3C=C(C=C4)O
CHEMBL188471 5ht1a_rat Rat No 9.1 IC50 = 0.8 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
408 9 1 4 5.0 CCOC1=CC=C(C=C1)N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)OC
CHEMBL362771 5ht1a_rat Rat No 9.1 IC50 = 0.8 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
349 6 2 3 3.5 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)O)C4=CC=CC=C4
CHEMBL431367 5ht1a_rat Rat Yes 9.1 IC50 = 0.8 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
346 6 2 2 4.6 C1CN(CC=C1C2=CC=CC=C2)CCCCC3=CNC4=C3C=C(C=C4)O
CHEMBL83625 5ht1a_rat Rat No 9.1 IC50 = 0.8 Funct
In vitro binding affinity was measured on serotonergic 5-hydroxytryptamine 1A receptor by displacement of [3H]- tetralinIn vitro binding affinity was measured on serotonergic 5-hydroxytryptamine 1A receptor by displacement of [3H]- tetralin
426 6 0 6 3.9 C1CCC2C(C1)C=NN(C2=O)CCCCN3CCN(CC3)C4=NSC5=CC=CC=C54
CHEMBL185938 5ht1a_rat Rat No 9.1 IC50 = 0.9 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
420 8 3 4 2.4 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C(=O)N)C4=CC=C(C=C4)C(=O)N
CHEMBL360179 5ht1a_rat Rat No 9.1 IC50 = 0.9 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
534 15 2 7 3.3 CCOCCOCCOC1=CC=CC(=C1C#N)N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)C(=O)N
CHEMBL185938 5ht1a_rat Rat No 9.1 IC50 = 0.9 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
420 8 3 4 2.4 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C(=O)N)C4=CC=C(C=C4)C(=O)N
CHEMBL360179 5ht1a_rat Rat No 9.1 IC50 = 0.9 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
534 15 2 7 3.3 CCOCCOCCOC1=CC=CC(=C1C#N)N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)C(=O)N
CHEMBL1210154 5ht1a_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293 cellsDisplacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293 cells
336 5 1 4 4.7 CC(=NOC(=O)NC1=CC=CC=C1)C2=CC=CC(=C2)C3=CC=CS3
CHEMBL185899 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
422 9 1 5 4.4 CC(=O)OC1=CC=C(C=C1)N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)OC
CHEMBL363932 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
348 6 2 2 4.1 C1CN(CCC1C2=CC=CC=C2)CCCCC3=CNC4=C3C=C(C=C4)O
CHEMBL359566 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
417 6 1 6 4.2 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC=CC5=NSN=C54
CHEMBL427523 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
389 7 1 4 4.3 COC1=CC=CC=C1N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)C#N
CHEMBL189758 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
389 7 1 4 4.3 COC1=CC=C(C=C1)N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)C#N
CHEMBL189709 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
417 6 1 5 4.1 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OCCO5
CHEMBL418499 5ht1a_human Human No 9.0 IC50 = 1 Funct
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPATAffinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPAT
421 4 0 7 4.6 CN1C2=C(C=C(C=C2)CCN3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F)SC1=O
CHEMBL27650 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Binding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranesBinding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranes
429 8 0 5 4.2 CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL50188 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Binding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranesBinding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranes
429 8 0 5 4.2 CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL27763 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Binding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranesBinding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranes
429 8 1 5 4.3 CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C3CC4=C(C=CC=C4O)OC3
CHEMBL28287 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Binding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranesBinding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranes
445 9 0 6 4.3 CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL50722 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Binding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranesBinding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranes
445 9 0 6 4.3 CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL28312 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Binding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranesBinding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranes
427 11 1 5 4.6 CCCN(CCCCNC(=O)C1=CC=CC=C1OC)C2CC3=C(C=CC=C3OC)OC2
CHEMBL48925 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Binding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranesBinding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranes
427 11 1 5 4.6 CCCN(CCCCNC(=O)C1=CC=CC=C1OC)C2CC3=C(C=CC=C3OC)OC2
CHEMBL1210154 5ht1a_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293 cellsDisplacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293 cells
336 5 1 4 4.7 CC(=NOC(=O)NC1=CC=CC=C1)C2=CC=CC(=C2)C3=CC=CS3
CHEMBL185899 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
422 9 1 5 4.4 CC(=O)OC1=CC=C(C=C1)N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)OC
CHEMBL363932 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Inhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT bindign to rat hydroxytryptamine 1A receptor expressed in CHO cells
348 6 2 2 4.1 C1CN(CCC1C2=CC=CC=C2)CCCCC3=CNC4=C3C=C(C=C4)O
CHEMBL359566 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
417 6 1 6 4.2 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC=CC5=NSN=C54
CHEMBL427523 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
389 7 1 4 4.3 COC1=CC=CC=C1N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)C#N
CHEMBL189758 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
389 7 1 4 4.3 COC1=CC=C(C=C1)N2CCN(CC2)CCCCC3=CNC4=C3C=C(C=C4)C#N
CHEMBL189709 5ht1a_rat Rat No 9.0 IC50 = 1 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
417 6 1 5 4.1 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OCCO5
CHEMBL174703 5ht1a_rat Rat No 9.0 IC50 = 1.1 Funct
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.
413 7 0 5 4.7 COC1=CC=CC=C1N2CCN(CC2)CCSC3CCCC4=C3C=CC=C4OC
CHEMBL56 5ht1a_human Human Yes 9.0 IC50 = 1.1 Funct
Displacement of radiolabeled 8OH-DPAT from human 5HT1A receptorDisplacement of radiolabeled 8OH-DPAT from human 5HT1A receptor
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL56 5ht1a_rat Rat Yes 9.0 IC50 = 1.1 Funct
In vitro ability to inhibit binding of radioligand [3H]8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortexIn vitro ability to inhibit binding of radioligand [3H]8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL186424 5ht1a_rat Rat No 9.0 IC50 = 1.1 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
383 6 1 4 4.1 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC=C(C=C4)C#N
CHEMBL56 5ht1a_rat Rat Yes 9.0 IC50 = 1.1 Funct
In vitro ability to inhibit binding of radioligand [3H]8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortexIn vitro ability to inhibit binding of radioligand [3H]8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL56 5ht1a_rat Rat Yes 9.0 IC50 = 1.1 Funct
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL186424 5ht1a_rat Rat No 9.0 IC50 = 1.1 Funct
Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsInhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cells
383 6 1 4 4.1 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC=C(C=C4)C#N
CHEMBL174083 5ht1a_rat Rat No 9.0 IC50 = 1.1 Funct
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.
371 6 0 4 4.9 COC1=CC=CC=C1N2CCN(CC2)CCCC3CCCC4=C3SC=C4
CHEMBL278876 5ht1a_rat Rat No 8.9 IC50 = 1.2 Funct