Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL75642 5ht1d_cavpo Guinea pig No 10.4 EC50 = 0.0 nM Bind
Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigraCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigra
355 3 1 4 4.0 CN1CCC[C@@H]1Cc1c[nH]c2ccc(-n3cnc4cc(C#N)ccc43)cc12
CHEMBL65367 5ht1d_human Human No 10.0 EC50 = 0.1 nM Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
400 7 1 5 3.5 c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL65367 5ht1d_human Human No 10.0 EC50 = 0.1 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
400 7 1 5 3.5 c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL63167 5ht1d_human Human No 9.7 EC50 = 0.2 nM Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
485 7 1 4 5.7 FC1(Cc2ccccc2C(F)(F)F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL161176 5ht1d_human Human No 9.7 EC50 = 0.2 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
457 8 2 6 3.5 CC(=O)Nc1cccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL163462 5ht1d_human Human No 9.7 EC50 = 0.2 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
443 8 2 6 2.5 NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL65367 5ht1d_human Human No 9.7 EC50 = 0.2 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
400 7 1 5 3.5 c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL357034 5ht1d_human Human Yes 9.7 EC50 = 0.2 nM Funct
Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor
230 3 2 1 3.2 CNCCc1c[nH]c2ccc(C(C)(C)C)cc12
CHEMBL352234 5ht1d_human Human No 9.6 EC50 = 0.2 nM Funct
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.24-0.55Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.24-0.55
408 7 2 5 2.4 COc1cccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)c1
CHEMBL138872 5ht1d_human Human No 9.5 EC50 = 0.3 nM Funct
Ability to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptor
304 4 1 4 2.9 CN(C)CCn1ccc2ccc(C3(O)CCSCC3)cc21
CHEMBL164046 5ht1d_human Human No 9.5 EC50 = 0.3 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
428 8 2 5 4.1 CC(C)(NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1
CHEMBL161723 5ht1d_human Human No 9.5 EC50 = 0.3 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
418 7 1 5 3.6 Fc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL162722 5ht1d_human Human No 9.5 EC50 = 0.3 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
428 8 1 5 4.1 CC(CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL163386 5ht1d_human Human No 9.5 EC50 = 0.3 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
430 8 2 6 3.0 OCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL163573 5ht1d_human Human No 9.5 EC50 = 0.3 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
401 7 1 6 2.9 c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1
CHEMBL164111 5ht1d_human Human No 9.5 EC50 = 0.3 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
390 7 1 6 3.1 c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1
CHEMBL422366 5ht1d_human Human No 9.5 EC50 = 0.3 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
401 7 1 6 2.9 c1cncc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL294732 5ht1d_human Human No 9.4 EC50 = 0.4 nM Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
417 7 1 4 4.7 FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL296161 5ht1d_human Human No 9.4 EC50 = 0.4 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
255 4 1 4 1.9 CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12
CHEMBL421064 5ht1d_human Human No 9.4 EC50 = 0.5 nM Funct
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1D-beta receptor in CHO-K1 cellsCompound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1D-beta receptor in CHO-K1 cells
378 6 2 4 2.4 NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4)CC3)cc12
CHEMBL296161 5ht1d_human Human No 9.4 EC50 = 0.5 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
255 4 1 4 1.9 CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12
CHEMBL294732 5ht1d_human Human No 9.3 EC50 = 0.5 nM Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
417 7 1 4 4.7 FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL146285 5ht1d_human Human No 9.3 EC50 = 0.5 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
446 8 2 5 4.6 CC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1
CHEMBL83426 5ht1d_human Human No 9.3 EC50 = 0.5 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
412 5 1 5 3.5 CN1[C@@H](Cc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]2CN(Cc3ccccc3)C[C@@H]21
CHEMBL160070 5ht1d_human Human No 9.3 EC50 = 0.5 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
446 9 3 4 4.0 C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1)c1ccccc1
CHEMBL162805 5ht1d_human Human No 9.3 EC50 = 0.5 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
390 7 1 6 3.1 c1coc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL490417 5ht1d_human Human No 9.3 EC50 = 0.5 nM Funct
Agonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assayAgonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay
402 4 1 5 3.2 Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1
CHEMBL294547 5ht1d_human Human No 9.2 EC50 = 0.6 nM Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
399 7 1 4 4.6 c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL294547 5ht1d_human Human No 9.2 EC50 = 0.6 nM Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
399 7 1 4 4.6 c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL120055 5ht1d_human Human No 9.2 EC50 = 0.6 nM Funct
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.6-2.0Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.6-2.0
392 6 2 4 2.7 Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1
CHEMBL321818 5ht1d_human Human No 9.2 EC50 = 0.6 nM Funct
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.6-2.0Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.6-2.0
392 6 2 4 2.7 Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1
CHEMBL116153 5ht1d_human Human No 9.2 EC50 = 0.6 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
450 8 1 5 3.8 Fc1cc(F)cc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL159396 5ht1d_human Human No 9.2 EC50 = 0.6 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
388 6 1 7 2.3 c1cnc(N2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1
CHEMBL159759 5ht1d_human Human No 9.2 EC50 = 0.6 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
414 8 2 5 4.0 C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1
CHEMBL119668 5ht1d_human Human Yes 9.2 EC50 = 0.7 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
450 8 1 5 3.8 Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F
CHEMBL313714 5ht1d_human Human Yes 9.1 EC50 = 0.8 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
462 9 3 6 3.6 OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1
CHEMBL434125 5ht1d_human Human No 9.1 EC50 = 0.8 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
443 9 3 5 4.1 OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1
CHEMBL420965 5ht1d_human Human No 9.1 EC50 = 0.8 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
400 8 2 5 3.4 c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL420965 5ht1d_human Human No 9.1 EC50 = 0.8 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
400 8 2 5 3.4 c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL164035 5ht1d_human Human No 9.1 EC50 = 0.8 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
471 8 1 6 3.1 CN(C)C(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL145815 5ht1d_human Human No 9.1 EC50 = 0.9 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
458 10 2 6 4.1 COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL333341 5ht1d_human Human No 9.1 EC50 = 0.9 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
442 9 1 5 4.5 CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL432332 5ht1d_human Human No 9.1 EC50 = 0.9 nM Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
417 7 1 4 4.6 FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1
CHEMBL333341 5ht1d_human Human No 9.1 EC50 = 0.9 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
442 9 1 5 4.5 CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL117633 5ht1d_human Human No 9.1 EC50 = 0.9 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
414 8 1 5 3.5 c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL420965 5ht1d_human Human No 9.0 EC50 = 0.9 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
400 8 2 5 3.4 c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL1290716 5ht1d_human Human No 9.0 EC50 = 1 nM Funct
Agonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
412 4 0 5 3.8 Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)CC3)cccc2n1
CHEMBL143947 5ht1d_human Human No 9.0 EC50 = 1 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
458 9 3 6 3.9 C[C@@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL292779 5ht1d_human Human Yes 9.0 EC50 = 1 nM Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
432 8 1 5 3.7 Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1
CHEMBL292779 5ht1d_human Human Yes 9.0 EC50 = 1 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
432 8 1 5 3.7 Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1
CHEMBL162858 5ht1d_human Human No 9.0 EC50 = 1 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
401 7 1 6 2.9 c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1
CHEMBL313714 5ht1d_human Human Yes 9.0 EC50 = 1.1 nM Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
462 9 3 6 3.6 OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1
CHEMBL313714 5ht1d_human Human Yes 9.0 EC50 = 1.1 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
462 9 3 6 3.6 OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1
CHEMBL347665 5ht1d_human Human No 9.0 EC50 = 1.1 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
425 7 1 6 3.4 N#Cc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL292779 5ht1d_human Human Yes 8.9 EC50 = 1.2 nM Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
432 8 1 5 3.7 Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1
CHEMBL292779 5ht1d_human Human Yes 8.9 EC50 = 1.2 nM Funct
Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.
432 8 1 5 3.7 Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1
CHEMBL85668 5ht1d_human Human No 8.9 EC50 = 1.2 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
411 5 1 4 4.1 CN1[C@@H](Cc2c[nH]c3ccc(-n4ccnc4)cc23)C[C@@H]2CN(Cc3ccccc3)C[C@@H]21
CHEMBL161696 5ht1d_human Human No 8.9 EC50 = 1.2 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
434 7 1 5 4.2 Clc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL356808 5ht1d_human Human No 8.9 EC50 = 1.3 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
454 8 2 5 4.7 c1ccc2c(c1)CCC2NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL83597 5ht1d_rat Rat Yes 8.9 EC50 = 1.3 nM Funct
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor
351 5 2 5 3.9 CN1CCC[C@@H]1Cc1c[nH]c2ccc(Nc3ncccc3[N+](=O)[O-])cc12
CHEMBL84107 5ht1d_rat Rat No 8.9 EC50 = 1.3 nM Funct
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor
337 5 3 5 3.5 O=[N+]([O-])c1cccnc1Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1
CHEMBL349185 5ht1d_human Human No 8.9 EC50 = 1.3 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
390 8 2 6 3.0 c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)co1
CHEMBL116031 5ht1d_human Human No 8.9 EC50 = 1.4 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
432 8 1 5 3.7 Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL304857 5ht1d_human Human No 8.8 EC50 = 1.5 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
428 8 1 5 4.3 CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL304857 5ht1d_human Human No 8.8 EC50 = 1.5 nM Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
428 8 1 5 4.3 CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL331970 5ht1d_human Human No 8.8 EC50 = 1.5 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
428 8 2 5 4.5 C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL115750 5ht1d_human Human No 8.8 EC50 = 1.5 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
432 8 1 5 3.7 Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL116031 5ht1d_human Human No 8.8 EC50 = 1.5 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
432 8 1 5 3.7 Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL117579 5ht1d_human Human No 8.8 EC50 = 1.5 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
414 8 1 5 3.7 CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1
CHEMBL115750 5ht1d_human Human No 8.8 EC50 = 1.5 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
432 8 1 5 3.7 Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL1278 5ht1d_human Human Yes 8.8 EC50 = 1.6 nM Funct
Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor
335 5 2 3 2.1 CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C
CHEMBL304857 5ht1d_human Human No 8.8 EC50 = 1.6 nM Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
428 8 1 5 4.3 CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL64004 5ht1d_human Human No 8.8 EC50 = 1.6 nM Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
464 8 1 5 4.2 CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1
CHEMBL117579 5ht1d_human Human No 8.8 EC50 = 1.6 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
414 8 1 5 3.7 CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1
CHEMBL304857 5ht1d_human Human No 8.8 EC50 = 1.6 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
428 8 1 5 4.3 CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL333089 5ht1d_human Human No 8.8 EC50 = 1.6 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
471 9 2 6 3.5 CC(=O)Nc1cccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL88893 5ht1d_human Human No 8.8 EC50 = 1.7 nM Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
480 9 3 6 3.6 OC[C@H](NC1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1
CHEMBL118012 5ht1d_human Human No 8.8 EC50 = 1.7 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
444 9 3 6 3.5 OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL159483 5ht1d_human Human No 8.8 EC50 = 1.7 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
432 9 3 4 3.5 O=C1N[C@@H](Cc2ccc3[nH]cc(CCN4CC[C@@H](CNCc5ccccc5)C4)c3c2)CO1
CHEMBL117633 5ht1d_human Human No 8.8 EC50 = 1.7 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
414 8 1 5 3.5 c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL348962 5ht1d_human Human No 8.8 EC50 = 1.7 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
443 9 2 6 3.3 CNCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL148233 5ht1d_human Human No 8.7 EC50 = 1.8 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
406 8 1 5 4.0 CC(C)=CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL118012 5ht1d_human Human No 8.7 EC50 = 1.8 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
444 9 3 6 3.5 OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL351303 5ht1d_human Human No 8.7 EC50 = 1.8 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
430 9 3 6 2.9 OC[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1
CHEMBL119785 5ht1d_human Human No 8.7 EC50 = 1.8 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
471 9 2 6 3.5 CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL65321 5ht1d_human Human No 8.7 EC50 = 1.9 nM Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
464 8 1 5 4.2 CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1cccc(F)c1
CHEMBL84712 5ht1d_human Human No 8.7 EC50 = 1.9 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
444 6 1 5 3.7 CN1[C@@H](Cc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]2CN(CCc3cccc(F)c3)C[C@@H]21
CHEMBL119668 5ht1d_human Human Yes 8.7 EC50 = 1.9 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
450 8 1 5 3.8 Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F
CHEMBL119785 5ht1d_human Human No 8.7 EC50 = 1.9 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
471 9 2 6 3.5 CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL423749 5ht1d_human Human No 8.0 EC50 = 10 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
458 9 2 6 3.8 CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](CO)c1ccccc1
CHEMBL349390 5ht1d_human Human No 8.0 EC50 = 10 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
457 9 3 6 3.4 CC(=O)Nc1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL324931 5ht1d_human Human No 7.0 EC50 = 105 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
310 4 1 5 1.5 CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL432332 5ht1d_human Human No 8.0 EC50 = 11 nM Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
417 7 1 4 4.6 FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1
CHEMBL159733 5ht1d_human Human No 8.0 EC50 = 11 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
428 9 1 5 3.8 CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1
CHEMBL163376 5ht1d_human Human No 8.0 EC50 = 11 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
468 7 1 5 4.5 FC(F)(F)c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL128 5ht1d_human Human Yes 7.9 EC50 = 12 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL143952 5ht1d_human Human No 7.9 EC50 = 12 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
478 9 2 6 3.4 O=S(=O)(NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL148087 5ht1d_human Human No 7.9 EC50 = 12 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
428 8 2 5 4.5 C[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL146729 5ht1d_human Human No 7.9 EC50 = 13 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
415 8 2 6 3.3 c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1
CHEMBL2112862 5ht1d_human Human No 7.9 EC50 = 13 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
456 7 3 6 3.4 O[C@@H]1Cc2ccccc2[C@H]1NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL331970 5ht1d_human Human No 7.9 EC50 = 13 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
428 8 2 5 4.5 C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL762 5ht1d_human Human Yes 6.9 EC50 = 137 nM Funct
Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)
260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C
CHEMBL308042 5ht1d_human Human No 6.9 EC50 = 138 nM Funct
Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)
230 3 1 2 3.0 Cc1cc(C(C)C)cc(C)c1CC1=NCCN1
CHEMBL147853 5ht1d_human Human No 7.9 EC50 = 14 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
458 10 3 6 3.3 OC[C@@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL80189 5ht1d_cavpo Guinea pig No 7.9 EC50 = 14 nM Bind
Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigraCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigra
305 4 1 4 3.0 CN(C)CCc1c[nH]c2ccc(-n3cnc4cccnc43)cc12
CHEMBL128 5ht1d_human Human Yes 7.9 EC50 = 14 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL148110 5ht1d_human Human No 7.8 EC50 = 15 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
471 9 3 6 3.8 C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)C(=O)Nc1ccccc1
CHEMBL423022 5ht1d_human Human No 7.8 EC50 = 15 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
458 9 3 6 3.9 C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@H](O)c1ccccc1
CHEMBL420874 5ht1d_human Human No 7.8 EC50 = 15 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
387 7 1 5 3.6 c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL420874 5ht1d_human Human No 7.8 EC50 = 15 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
387 7 1 5 3.6 c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL72178 5ht1d_human Human Yes 6.8 EC50 = 150 nM Funct
Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)
202 2 1 2 2.2 Cc1cc(C)c(CC2=NCCN2)c(C)c1
CHEMBL433108 5ht1d_human Human No 7.8 EC50 = 16 nM Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
464 8 1 5 4.3 CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL128 5ht1d_human Human Yes 7.8 EC50 = 16 nM Funct
Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL39 5ht1d_cavpo Guinea pig Yes 7.8 EC50 = 16 nM Bind
Inhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1D receptor of guinea pig substantia nigraInhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1D receptor of guinea pig substantia nigra
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL128 5ht1d_human Human Yes 7.8 EC50 = 16 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL70409 5ht1d_human Human No 5.8 EC50 = 1670 nM Funct
Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)
230 2 1 2 2.8 Cc1cc(C(C)(C)C)ccc1CC1=NCCN1
CHEMBL416688 5ht1d_human Human No 7.8 EC50 = 18 nM Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
446 8 1 5 4.2 CN(Cc1ccccc1)C1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL144002 5ht1d_human Human No 7.8 EC50 = 18 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
428 8 2 5 4.5 C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1
CHEMBL416688 5ht1d_human Human No 7.8 EC50 = 18 nM Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
446 8 1 5 4.2 CN(Cc1ccccc1)C1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL314213 5ht1d_rat Rat No 8.7 EC50 = 2 nM Funct
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor
325 6 2 5 3.3 CN(C)CCc1c[nH]c2ccc(Nc3ncccc3[N+](=O)[O-])cc12
CHEMBL84942 5ht1d_rat Rat Yes 8.7 EC50 = 2 nM Funct
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor
337 4 2 5 3.6 CN1CCC(c2c[nH]c3ccc(Nc4ncccc4[N+](=O)[O-])cc23)C1
CHEMBL164413 5ht1d_human Human No 8.7 EC50 = 2 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
390 7 2 6 2.2 c1c[nH]c(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)n1
CHEMBL326371 5ht1d_human Human No 8.7 EC50 = 2.1 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
401 8 1 5 3.8 c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL161410 5ht1d_human Human No 8.7 EC50 = 2.1 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
414 8 2 5 4.0 C[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1
CHEMBL326371 5ht1d_human Human No 8.7 EC50 = 2.1 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
401 8 1 5 3.8 c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL146991 5ht1d_human Human No 8.7 EC50 = 2.2 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
441 6 2 7 4.1 Oc1nc2ccccc2n1C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL116092 5ht1d_human Human No 8.6 EC50 = 2.3 nM Bind
Compound was tested for measuring agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorCompound was tested for measuring agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
281 4 1 4 2.4 c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1
CHEMBL116092 5ht1d_human Human No 8.6 EC50 = 2.3 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
281 4 1 4 2.4 c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1
CHEMBL352159 5ht1d_human Human No 8.6 EC50 = 2.3 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
430 7 1 5 3.8 S=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1
CHEMBL146132 5ht1d_human Human No 8.6 EC50 = 2.6 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
444 9 3 6 3.5 OC[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL67684 5ht1d_human Human No 8.6 EC50 = 2.6 nM Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
445 8 1 4 5.7 CC(CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL116092 5ht1d_human Human No 8.6 EC50 = 2.6 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
281 4 1 4 2.4 c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1
CHEMBL116092 5ht1d_human Human No 8.6 EC50 = 2.6 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
281 4 1 4 2.4 c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1
CHEMBL147660 5ht1d_human Human No 8.6 EC50 = 2.8 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
499 10 2 6 4.5 CC(=O)Nc1ccc(CN(C)CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL160581 5ht1d_human Human No 8.6 EC50 = 2.8 nM Funct
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 2.8-6.5Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 2.8-6.5
428 6 2 4 3.6 NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4cccc5ccccc45)CC3)cc12
CHEMBL349041 5ht1d_human Human No 8.6 EC50 = 2.8 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
390 8 2 6 3.0 c1coc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)c1
CHEMBL82204 5ht1d_human Human No 8.5 EC50 = 2.9 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
430 5 1 5 3.6 CN1[C@@H](Cc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]2CN(Cc3ccc(F)cc3)C[C@@H]21
CHEMBL128 5ht1d_human Human Yes 6.7 EC50 = 220 nM Bind
Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL148095 5ht1d_human Human No 7.6 EC50 = 25 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
440 7 2 5 4.4 c1ccc2c(c1)CCC2NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL905 5ht1d_human Human Yes 8.5 EC50 = 3 nM Funct
Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor
269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C
CHEMBL146483 5ht1d_human Human No 8.5 EC50 = 3 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
499 10 3 6 4.7 CC(=O)Nc1ccc([C@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL159683 5ht1d_human Human No 8.5 EC50 = 3 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
414 8 1 5 3.9 CN(Cc1ccccc1)C[C@@H]1CCCN1CCc1c[nH]c2ccc(-n3cnnc3)cc12
CHEMBL424154 5ht1d_human Human No 8.5 EC50 = 3 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
428 9 2 5 4.0 C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1)c1ccccc1
CHEMBL350153 5ht1d_human Human No 8.5 EC50 = 3.2 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
460 9 1 4 4.2 CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4C)cc23)C1
CHEMBL148194 5ht1d_human Human No 8.5 EC50 = 3.4 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
458 9 3 6 3.6 CC(CO)(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL423212 5ht1d_human Human No 8.5 EC50 = 3.5 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
434 8 1 6 4.3 CN(Cc1cccs1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL161780 5ht1d_human Human No 8.5 EC50 = 3.5 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
440 10 3 4 2.9 CNS(=O)(=O)Cc1ccc2[nH]cc(CCN3CC[C@@H](CNCc4ccccc4)C3)c2c1
CHEMBL146131 5ht1d_human Human No 8.4 EC50 = 3.6 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
458 10 3 6 3.3 OC[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL63432 5ht1d_human Human No 8.4 EC50 = 3.8 nM Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
450 8 1 5 3.6 Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL163462 5ht1d_human Human No 8.4 EC50 = 3.8 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
443 8 2 6 2.5 NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL356315 5ht1d_human Human No 7.5 EC50 = 30 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
458 9 3 6 3.9 C[C@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL128 5ht1d_human Human Yes 7.5 EC50 = 30 nM Funct
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 30-70Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 30-70
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL435060 5ht1d_human Human No 7.5 EC50 = 31 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
387 7 1 5 3.6 c1ccc(CO[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL1084132 5ht1d_human Human No 5.5 EC50 = 3162.3 nM Bind
Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor
245 3 1 3 1.9 c1ccc(N2CCN(CC3CCCCN3)C2)cc1
CHEMBL341854 5ht1d_human Human No 7.5 EC50 = 32 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
458 10 3 6 3.5 OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccccc1
CHEMBL420874 5ht1d_human Human No 7.5 EC50 = 33 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
387 7 1 5 3.6 c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL63258 5ht1d_human Human No 7.5 EC50 = 34 nM Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
451 8 1 5 4.6 FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1
CHEMBL305301 5ht1d_human Human No 7.5 EC50 = 35 nM Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
468 8 1 5 3.9 Fc1cccc(CCN2CCN(CC(F)(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL312448 5ht1d_human Human Yes 6.4 EC50 = 369 nM Funct
Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)
244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C
CHEMBL352123 5ht1d_human Human No 8.4 EC50 = 4 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
428 9 1 5 3.9 c1ccc(CCCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL159819 5ht1d_human Human No 8.4 EC50 = 4.1 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
400 8 2 5 3.4 c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL159819 5ht1d_human Human No 8.4 EC50 = 4.1 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
400 8 2 5 3.4 c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL146024 5ht1d_human Human No 8.4 EC50 = 4.2 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
434 8 1 6 4.3 CN(Cc1ccsc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL128 5ht1d_human Human Yes 8.4 EC50 = 4.3 nM Funct
Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL63432 5ht1d_human Human No 8.4 EC50 = 4.4 nM Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
450 8 1 5 3.6 Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL348864 5ht1d_human Human No 8.4 EC50 = 4.5 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
442 9 1 5 4.4 C[C@@H](c1ccccc1)N(C)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1
CHEMBL147838 5ht1d_human Human No 8.3 EC50 = 4.7 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
468 7 1 5 5.4 c1ccc(C2CCCCN2C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL161192 5ht1d_human Human No 8.3 EC50 = 4.9 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
414 9 2 5 3.5 c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(Cn5cncn5)cc34)C2)cc1
CHEMBL137485 5ht1d_cavpo Guinea pig No 7.4 EC50 = 43 nM Funct
Effect on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.Effect on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.
244 3 1 2 2.8 COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1
CHEMBL146335 5ht1d_human Human No 8.3 EC50 = 5 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
471 9 3 6 3.9 CC(=O)Nc1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL63799 5ht1d_human Human No 8.3 EC50 = 5 nM Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
449 8 1 4 5.3 Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL1290596 5ht1d_human Human No 8.3 EC50 = 5.0 nM Funct
Agonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
414 4 1 4 4.1 Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4CCC(=O)N5)CC3)cccc2n1
CHEMBL63799 5ht1d_human Human No 8.3 EC50 = 5.1 nM Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
449 8 1 4 5.3 Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL146628 5ht1d_human Human No 8.3 EC50 = 5.1 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
458 10 3 6 3.9 OCCC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL39 5ht1d_cavpo Guinea pig Yes 8.3 EC50 = 5.2 nM Funct
Effect on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.Effect on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht1d_rat Rat Yes 8.3 EC50 = 5.2 nM Funct
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL128 5ht1d_human Human Yes 8.3 EC50 = 5.3 nM Funct
Ability to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptor
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL143893 5ht1d_human Human No 8.3 EC50 = 5.6 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
428 9 2 5 4.2 c1ccc(CNCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL1085672 5ht1d_human Human No 6.3 EC50 = 501.2 nM Bind
Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor
293 3 1 2 2.7 O=C1N(CC2CCCCN2)CCN1c1cccc(Cl)c1
CHEMBL117249 5ht1d_human Human No 7.3 EC50 = 53 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
324 5 1 5 1.9 CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL117249 5ht1d_human Human No 7.3 EC50 = 54 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
324 5 1 5 1.9 CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL146129 5ht1d_human Human No 8.2 EC50 = 6 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
476 10 4 5 3.5 O=C1N[C@@H](Cc2ccc3[nH]cc(CCCN4CCC(N[C@@H](CO)c5ccccc5)CC4)c3c2)CO1
CHEMBL163127 5ht1d_human Human No 8.2 EC50 = 6.1 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
457 8 2 6 3.5 CC(=O)Nc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL147907 5ht1d_human Human No 8.2 EC50 = 6.2 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
427 8 2 4 5.1 C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1
CHEMBL348815 5ht1d_human Human No 8.2 EC50 = 6.2 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
414 9 2 5 3.4 c1ccc(CCNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL146502 5ht1d_human Human No 8.2 EC50 = 6.8 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
442 9 2 5 4.4 C[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL97450 5ht1d_human Human Yes 7.2 EC50 = 68 nM Funct
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1D-beta receptor in CHO-K1 cellsCompound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1D-beta receptor in CHO-K1 cells
302 11 2 2 4.8 CCCCCCCCCOc1ccc2c(c1)c(CCN)c[nH]2
CHEMBL357408 5ht1d_human Human No 8.2 EC50 = 7.1 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
404 8 2 6 3.5 c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1
CHEMBL147961 5ht1d_human Human No 8.1 EC50 = 7.4 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
444 9 3 6 3.5 OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1
CHEMBL162899 5ht1d_human Human No 8.1 EC50 = 7.5 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
414 7 1 5 3.0 O=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1
CHEMBL117046 5ht1d_human Human No 8.1 EC50 = 7.6 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
414 8 2 5 3.9 c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL349528 5ht1d_human Human No 8.1 EC50 = 7.8 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
297 4 2 5 1.4 O[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1
CHEMBL351311 5ht1d_human Human No 8.1 EC50 = 7.8 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
415 8 1 6 2.9 c1cncc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL117046 5ht1d_human Human No 8.1 EC50 = 8 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
414 8 2 5 3.9 c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL905 5ht1d_human Human Yes 8.1 EC50 = 8.4 nM Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C
CHEMBL39 5ht1d_cavpo Guinea pig Yes 8.1 EC50 = 8.5 nM Bind
Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigraCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigra
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL441296 5ht1d_human Human No 8.1 EC50 = 8.7 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
430 9 3 6 2.9 OC[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1
CHEMBL148085 5ht1d_human Human No 8.1 EC50 = 8.9 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
418 8 1 6 3.9 CN(Cc1ccoc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL344537 5ht1d_human Human No 8.1 EC50 = 8.9 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
490 11 2 6 4.3 COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccc(F)cc1
CHEMBL324931 5ht1d_human Human No 7.1 EC50 = 80 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
310 4 1 5 1.5 CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL342805 5ht1d_human Human No 8.0 EC50 = 9.3 nM Bind
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
487 10 3 7 3.6 NC(=O)OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL161066 5ht1d_human Human No 8.0 EC50 = 9.5 nM Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
401 8 2 6 2.8 c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)ccn1
CHEMBL128 5ht1d_rat Rat Yes 7.0 EC50 = 97 nM Funct
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL22744 5ht1d_human Human No 10.3 IC50 = 0.1 nM Bind
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting
606 14 6 4 6.5 NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1
CHEMBL22744 5ht1d_human Human No 10.3 IC50 = 0.1 nM Bind
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
606 14 6 4 6.5 NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1
CHEMBL112507 5ht1d_human Human No 10.0 IC50 = 0.1 nM Bind
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
415 7 2 5 3.8 OC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL161723 5ht1d_human Human No 10.0 IC50 = 0.1 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
418 7 1 5 3.6 Fc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL65367 5ht1d_human Human No 10.0 IC50 = 0.1 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
400 7 1 5 3.5 c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL65824 5ht1d_human Human No 10.0 IC50 = 0.1 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
435 7 1 4 4.9 Fc1ccccc1CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL22961 5ht1d_human Human No 10.0 IC50 = 0.1 nM Bind
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
620 15 6 4 6.9 NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1
CHEMBL65367 5ht1d_human Human No 9.9 IC50 = 0.1 nM Bind
Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cells
400 7 1 5 3.5 c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL65367 5ht1d_human Human No 9.9 IC50 = 0.1 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
400 7 1 5 3.5 c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL65367 5ht1d_human Human No 9.9 IC50 = 0.1 nM Funct
Inhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assayInhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assay
400 7 1 5 3.5 c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL161176 5ht1d_human Human No 9.7 IC50 = 0.2 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
457 8 2 6 3.5 CC(=O)Nc1cccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL163462 5ht1d_human Human No 9.7 IC50 = 0.2 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
443 8 2 6 2.5 NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL65367 5ht1d_human Human No 9.7 IC50 = 0.2 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
400 7 1 5 3.5 c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL160070 5ht1d_human Human No 9.5 IC50 = 0.3 nM Bind
Affinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding technique
446 9 3 4 4.0 C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1)c1ccccc1
CHEMBL296161 5ht1d_human Human No 9.5 IC50 = 0.3 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
255 4 1 4 1.9 CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12
CHEMBL294547 5ht1d_human Human No 9.5 IC50 = 0.3 nM Bind
Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cells
399 7 1 4 4.6 c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL296161 5ht1d_human Human No 9.5 IC50 = 0.3 nM Bind
Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
255 4 1 4 1.9 CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12
CHEMBL160070 5ht1d_human Human No 9.5 IC50 = 0.3 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
446 9 3 4 4.0 C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1)c1ccccc1
CHEMBL296161 5ht1d_human Human No 9.5 IC50 = 0.3 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
255 4 1 4 1.9 CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12
CHEMBL422366 5ht1d_human Human No 9.5 IC50 = 0.3 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
401 7 1 6 2.9 c1cncc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL294547 5ht1d_human Human No 9.5 IC50 = 0.3 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
399 7 1 4 4.6 c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL63167 5ht1d_human Human No 9.5 IC50 = 0.3 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
485 7 1 4 5.7 FC1(Cc2ccccc2C(F)(F)F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL294547 5ht1d_human Human No 9.5 IC50 = 0.3 nM Funct
Inhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assayInhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assay
399 7 1 4 4.6 c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL89878 5ht1d_human Human No 9.5 IC50 = 0.3 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
330 7 3 5 1.9 CCc1ccc2c(c1)OC(CNCCCNC1=NCCCN1)CC2
CHEMBL22960 5ht1d_human Human No 9.5 IC50 = 0.3 nM Bind
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
676 19 6 4 8.5 NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1
CHEMBL159483 5ht1d_human Human No 9.5 IC50 = 0.4 nM Bind
Affinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding technique
432 9 3 4 3.5 O=C1N[C@@H](Cc2ccc3[nH]cc(CCN4CC[C@@H](CNCc5ccccc5)C4)c3c2)CO1
CHEMBL331970 5ht1d_human Human No 9.5 IC50 = 0.4 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
428 8 2 5 4.5 C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL159483 5ht1d_human Human No 9.5 IC50 = 0.4 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
432 9 3 4 3.5 O=C1N[C@@H](Cc2ccc3[nH]cc(CCN4CC[C@@H](CNCc5ccccc5)C4)c3c2)CO1
CHEMBL294547 5ht1d_human Human No 9.5 IC50 = 0.4 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
399 7 1 4 4.6 c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL331970 5ht1d_human Human No 9.4 IC50 = 0.4 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
428 8 2 5 4.5 C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL162805 5ht1d_human Human No 9.4 IC50 = 0.4 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
390 7 1 6 3.1 c1coc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL163573 5ht1d_human Human No 9.4 IC50 = 0.4 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
401 7 1 6 2.9 c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1
CHEMBL65765 5ht1d_human Human No 9.4 IC50 = 0.4 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
435 7 1 4 4.9 Fc1cccc(CC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL326125 5ht1d_human Human No 9.4 IC50 = 0.5 nM Bind
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
444 9 3 6 3.3 OC1(CNCc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL159759 5ht1d_human Human No 9.4 IC50 = 0.5 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
414 8 2 5 4.0 C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1
CHEMBL349185 5ht1d_human Human No 9.4 IC50 = 0.5 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
390 8 2 6 3.0 c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)co1
CHEMBL420965 5ht1d_human Human No 9.3 IC50 = 0.5 nM Bind
Affinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding technique
400 8 2 5 3.4 c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL420965 5ht1d_human Human No 9.3 IC50 = 0.5 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
400 8 2 5 3.4 c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL420965 5ht1d_human Human No 9.3 IC50 = 0.5 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
400 8 2 5 3.4 c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL148233 5ht1d_human Human No 9.3 IC50 = 0.5 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
406 8 1 5 4.0 CC(C)=CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL292779 5ht1d_human Human Yes 9.3 IC50 = 0.5 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
432 8 1 5 3.7 Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1
CHEMBL116031 5ht1d_human Human No 9.3 IC50 = 0.5 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
432 8 1 5 3.7 Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL161696 5ht1d_human Human No 9.3 IC50 = 0.5 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
434 7 1 5 4.2 Clc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL292779 5ht1d_human Human Yes 9.3 IC50 = 0.5 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
432 8 1 5 3.7 Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1
CHEMBL420965 5ht1d_human Human No 9.2 IC50 = 0.6 nM Bind
Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)
400 8 2 5 3.4 c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL148087 5ht1d_human Human No 9.2 IC50 = 0.6 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
428 8 2 5 4.5 C[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL292779 5ht1d_human Human Yes 9.2 IC50 = 0.6 nM Bind
Compound was evaluated for the affinity at 5-hydroxytryptamine 1D receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1D receptor
432 8 1 5 3.7 Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1
CHEMBL420965 5ht1d_human Human No 9.2 IC50 = 0.6 nM Bind
Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
400 8 2 5 3.4 c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL146483 5ht1d_human Human No 9.2 IC50 = 0.6 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
499 10 3 6 4.7 CC(=O)Nc1ccc([C@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL147660 5ht1d_human Human No 9.2 IC50 = 0.6 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
499 10 2 6 4.5 CC(=O)Nc1ccc(CN(C)CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL159396 5ht1d_human Human No 9.2 IC50 = 0.6 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
388 6 1 7 2.3 c1cnc(N2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1
CHEMBL162858 5ht1d_human Human No 9.2 IC50 = 0.6 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
401 7 1 6 2.9 c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1
CHEMBL292779 5ht1d_human Human Yes 9.2 IC50 = 0.6 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
432 8 1 5 3.7 Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1
CHEMBL116031 5ht1d_human Human No 9.2 IC50 = 0.6 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
432 8 1 5 3.7 Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL292779 5ht1d_human Human Yes 9.2 IC50 = 0.6 nM Bind
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting
432 8 1 5 3.7 Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1
CHEMBL67684 5ht1d_human Human No 9.2 IC50 = 0.6 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
445 8 1 4 5.7 CC(CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL116161 5ht1d_human Human No 9.2 IC50 = 0.7 nM Bind
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
450 7 2 6 3.6 CC1(C)CCCN(CC2(O)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)C1
CHEMBL331819 5ht1d_human Human No 9.2 IC50 = 0.7 nM Bind
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
424 9 2 6 3.1 CC(C)CN(C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL85668 5ht1d_human Human No 9.2 IC50 = 0.7 nM Bind
Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)
411 5 1 4 4.1 CN1[C@@H](Cc2c[nH]c3ccc(-n4ccnc4)cc23)C[C@@H]2CN(Cc3ccccc3)C[C@@H]21
CHEMBL117579 5ht1d_human Human No 9.2 IC50 = 0.7 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
414 8 1 5 3.7 CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1
CHEMBL117579 5ht1d_human Human No 9.2 IC50 = 0.7 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
414 8 1 5 3.7 CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1
CHEMBL348864 5ht1d_human Human No 9.2 IC50 = 0.7 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
442 9 1 5 4.4 C[C@@H](c1ccccc1)N(C)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1
CHEMBL434125 5ht1d_human Human No 9.2 IC50 = 0.7 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
443 9 3 5 4.1 OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1
CHEMBL163386 5ht1d_human Human No 9.2 IC50 = 0.7 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
430 8 2 6 3.0 OCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL347665 5ht1d_human Human No 9.2 IC50 = 0.7 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
425 7 1 6 3.4 N#Cc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL116153 5ht1d_human Human No 9.2 IC50 = 0.7 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
450 8 1 5 3.8 Fc1cc(F)cc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL63799 5ht1d_human Human No 9.2 IC50 = 0.7 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
449 8 1 4 5.3 Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL161410 5ht1d_human Human No 9.1 IC50 = 0.7 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
414 8 2 5 4.0 C[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1
CHEMBL63799 5ht1d_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
449 8 1 4 5.3 Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL88283 5ht1d_human Human No 9.1 IC50 = 0.8 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
332 7 3 6 1.3 COc1cccc2c1OC(CNCCCNC1=NCCCN1)CC2
CHEMBL82204 5ht1d_human Human No 9.1 IC50 = 0.8 nM Bind
Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)
430 5 1 5 3.6 CN1[C@@H](Cc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]2CN(Cc3ccc(F)cc3)C[C@@H]21
CHEMBL159683 5ht1d_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
414 8 1 5 3.9 CN(Cc1ccccc1)C[C@@H]1CCCN1CCc1c[nH]c2ccc(-n3cnnc3)cc12
CHEMBL115750 5ht1d_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
432 8 1 5 3.7 Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL162722 5ht1d_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
428 8 1 5 4.1 CC(CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL352159 5ht1d_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
430 7 1 5 3.8 S=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1
CHEMBL115750 5ht1d_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
432 8 1 5 3.7 Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL67460 5ht1d_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
449 8 1 4 5.3 Fc1ccccc1CCC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL348304 5ht1d_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
401 8 1 5 4.0 c1ccc(COC[C@@H]2CCCN2CCc2c[nH]c3ccc(-n4cnnc4)cc23)cc1
CHEMBL21862 5ht1d_human Human No 9.1 IC50 = 0.8 nM Bind
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
592 13 6 4 6.2 NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1
CHEMBL83426 5ht1d_human Human No 9.1 IC50 = 0.9 nM Bind
Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)
412 5 1 5 3.5 CN1[C@@H](Cc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]2CN(Cc3ccccc3)C[C@@H]21
CHEMBL84070 5ht1d_human Human No 9.1 IC50 = 0.9 nM Bind
Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)
413 7 1 4 4.3 CN(Cc1ccccc1)C[C@H]1C[C@H](Cc2c[nH]c3ccc(-n4ccnc4)cc23)N(C)C1
CHEMBL313714 5ht1d_human Human Yes 9.1 IC50 = 0.9 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
462 9 3 6 3.6 OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1
CHEMBL294732 5ht1d_human Human No 9.1 IC50 = 0.9 nM Bind
Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cells
417 7 1 4 4.7 FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL313714 5ht1d_human Human Yes 9.1 IC50 = 0.9 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
462 9 3 6 3.6 OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1
CHEMBL143947 5ht1d_human Human No 9.1 IC50 = 0.9 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
458 9 3 6 3.9 C[C@@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL333341 5ht1d_human Human No 9.1 IC50 = 0.9 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
442 9 1 5 4.5 CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL119668 5ht1d_human Human Yes 9.1 IC50 = 0.9 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
450 8 1 5 3.8 Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F
CHEMBL348962 5ht1d_human Human No 9.1 IC50 = 0.9 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
443 9 2 6 3.3 CNCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL313714 5ht1d_human Human Yes 9.1 IC50 = 0.9 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
462 9 3 6 3.6 OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1
CHEMBL294732 5ht1d_human Human No 9.1 IC50 = 0.9 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
417 7 1 4 4.7 FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL432332 5ht1d_human Human No 9.1 IC50 = 0.9 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
417 7 1 4 4.6 FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1
CHEMBL65321 5ht1d_human Human No 9.1 IC50 = 0.9 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
464 8 1 5 4.2 CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1cccc(F)c1
CHEMBL294732 5ht1d_human Human No 9.1 IC50 = 0.9 nM Funct
Inhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assayInhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assay
417 7 1 4 4.7 FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL333341 5ht1d_human Human No 9.0 IC50 = 1.0 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
442 9 1 5 4.5 CN(Cc1ccccc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL432332 5ht1d_human Human No 9.0 IC50 = 1.0 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
417 7 1 4 4.6 FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1
CHEMBL164046 5ht1d_human Human No 9.0 IC50 = 1 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
428 8 2 5 4.1 CC(C)(NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1
CHEMBL164035 5ht1d_human Human No 9.0 IC50 = 1 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
471 8 1 6 3.1 CN(C)C(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL351346 5ht1d_human Human No 9.0 IC50 = 1 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
414 7 1 5 4.1 CC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL119668 5ht1d_human Human Yes 9.0 IC50 = 1 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
450 8 1 5 3.8 Fc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1F
CHEMBL294732 5ht1d_human Human No 9.0 IC50 = 1 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
417 7 1 4 4.7 FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL293614 5ht1d_human Human No 9.0 IC50 = 1 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
449 8 1 4 5.3 Fc1ccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL304833 5ht1d_human Human No 9.0 IC50 = 1 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
464 8 1 5 4.2 CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1F
CHEMBL64004 5ht1d_human Human No 9.0 IC50 = 1 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
464 8 1 5 4.2 CC(CN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1
CHEMBL161780 5ht1d_human Human No 9.0 IC50 = 1.1 nM Bind
Affinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding technique
440 10 3 4 2.9 CNS(=O)(=O)Cc1ccc2[nH]cc(CCN3CC[C@@H](CNCc4ccccc4)C3)c2c1
CHEMBL161045 5ht1d_human Human No 9.0 IC50 = 1.1 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
267 4 1 4 2.0 c1cc2[nH]cc(CCN3CCC3)c2cc1-n1cnnc1
CHEMBL161780 5ht1d_human Human No 9.0 IC50 = 1.1 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
440 10 3 4 2.9 CNS(=O)(=O)Cc1ccc2[nH]cc(CCN3CC[C@@H](CNCc4ccccc4)C3)c2c1
CHEMBL423599 5ht1d_human Human No 9.0 IC50 = 1.1 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
442 8 1 5 3.7 CC(=O)N(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1
CHEMBL356808 5ht1d_human Human No 9.0 IC50 = 1.1 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
454 8 2 5 4.7 c1ccc2c(c1)CCC2NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL164111 5ht1d_human Human No 9.0 IC50 = 1.1 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
390 7 1 6 3.1 c1cc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1
CHEMBL84712 5ht1d_human Human No 8.9 IC50 = 1.2 nM Bind
Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)
444 6 1 5 3.7 CN1[C@@H](Cc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]2CN(CCc3cccc(F)c3)C[C@@H]21
CHEMBL111899 5ht1d_human Human No 8.9 IC50 = 1.2 nM Bind
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
464 9 2 6 4.0 CN(CC1CCCCC1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL114877 5ht1d_human Human No 8.9 IC50 = 1.2 nM Bind
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
458 9 2 6 3.6 CN(Cc1ccccc1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL146991 5ht1d_human Human No 8.9 IC50 = 1.2 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
441 6 2 7 4.1 Oc1nc2ccccc2n1C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL114303 5ht1d_human Human No 8.9 IC50 = 1.3 nM Bind
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
472 9 2 6 3.9 Cc1ccccc1CN(C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL118012 5ht1d_human Human No 8.9 IC50 = 1.3 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
444 9 3 6 3.5 OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL118012 5ht1d_human Human No 8.9 IC50 = 1.3 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
444 9 3 6 3.5 OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL119785 5ht1d_human Human No 8.9 IC50 = 1.3 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
471 9 2 6 3.5 CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL119785 5ht1d_human Human No 8.9 IC50 = 1.3 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
471 9 2 6 3.5 CC(=O)Nc1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL75642 5ht1d_human Human No 8.9 IC50 = 1.3 nM Bind
Tested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligandTested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligand
355 3 1 4 4.0 CN1CCC[C@@H]1Cc1c[nH]c2ccc(-n3cnc4cc(C#N)ccc43)cc12
CHEMBL115989 5ht1d_human Human No 8.9 IC50 = 1.4 nM Bind
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
422 9 2 6 2.9 CN(CC1CC1)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL351303 5ht1d_human Human No 8.9 IC50 = 1.4 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
430 9 3 6 2.9 OC[C@@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1
CHEMBL343217 5ht1d_human Human No 8.9 IC50 = 1.4 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
476 10 2 6 4.3 COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1
CHEMBL343648 5ht1d_human Human No 8.9 IC50 = 1.4 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
442 9 2 5 4.7 C[C@@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL117633 5ht1d_human Human No 8.9 IC50 = 1.4 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
414 8 1 5 3.5 c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL162463 5ht1d_human Human No 8.9 IC50 = 1.4 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
386 6 1 5 3.5 c1ccc(N2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL117633 5ht1d_human Human No 8.9 IC50 = 1.4 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
414 8 1 5 3.5 c1ccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL88893 5ht1d_human Human No 8.9 IC50 = 1.4 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
480 9 3 6 3.6 OC[C@H](NC1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1
CHEMBL349041 5ht1d_human Human No 8.8 IC50 = 1.5 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
390 8 2 6 3.0 c1coc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)c1
CHEMBL146024 5ht1d_human Human No 8.8 IC50 = 1.5 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
434 8 1 6 4.3 CN(Cc1ccsc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL146338 5ht1d_human Human No 8.8 IC50 = 1.5 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
499 10 3 6 4.7 CC(=O)Nc1ccc([C@@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL147818 5ht1d_human Human No 8.8 IC50 = 1.5 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
471 10 2 6 4.0 CN(C)C[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL357634 5ht1d_human Human No 8.8 IC50 = 1.5 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
478 8 1 6 3.5 CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)S(=O)(=O)c1ccccc1
CHEMBL422243 5ht1d_human Human No 8.8 IC50 = 1.6 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
298 7 2 5 2.3 c1cnc(NCCCNCC2CCc3ccccc3O2)nc1
CHEMBL159819 5ht1d_human Human No 8.8 IC50 = 1.6 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
400 8 2 5 3.4 c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL159819 5ht1d_human Human No 8.8 IC50 = 1.6 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
400 8 2 5 3.4 c1ccc(CNC[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL143893 5ht1d_human Human No 8.8 IC50 = 1.6 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
428 9 2 5 4.2 c1ccc(CNCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL145982 5ht1d_human Human No 8.8 IC50 = 1.6 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
492 9 1 6 3.7 CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)S(=O)(=O)c1ccccc1
CHEMBL164413 5ht1d_human Human No 8.8 IC50 = 1.6 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
390 7 2 6 2.2 c1c[nH]c(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)n1
CHEMBL350153 5ht1d_human Human No 8.8 IC50 = 1.7 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
460 9 1 4 4.2 CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4C)cc23)C1
CHEMBL358072 5ht1d_human Human No 8.8 IC50 = 1.7 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
415 8 2 6 3.9 c1ccc(NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1
CHEMBL115352 5ht1d_human Human No 8.7 IC50 = 1.8 nM Bind
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
438 8 2 6 3.5 CN(CC(C)(C)C)CC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL333089 5ht1d_human Human No 8.7 IC50 = 1.8 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
471 9 2 6 3.5 CC(=O)Nc1cccc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL304197 5ht1d_human Human No 8.7 IC50 = 1.8 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
416 7 2 6 2.5 OC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCN(Cc2ccccc2)CC1
CHEMBL65215 5ht1d_human Human No 8.7 IC50 = 1.8 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
482 8 1 5 4.5 CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1
CHEMBL146285 5ht1d_human Human No 8.7 IC50 = 1.9 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
446 8 2 5 4.6 CC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccc(F)cc1
CHEMBL147838 5ht1d_human Human No 8.7 IC50 = 1.9 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
468 7 1 5 5.4 c1ccc(C2CCCCN2C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL417650 5ht1d_human Human No 8.7 IC50 = 2.0 nM Bind
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
353 9 3 2 4.8 CCCCCCCNC1CC=C(c2c[nH]c3ccc(C(N)=O)cc23)CC1
CHEMBL89007 5ht1d_human Human No 8.7 IC50 = 2.0 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
332 7 2 5 2.9 Clc1ccc(NCCCNCC2CCc3ccccc3O2)nn1
CHEMBL329207 5ht1d_human Human No 8.0 IC50 = 10 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
298 7 2 5 2.3 c1ccc2c(c1)CCC(CNCCCNc1ccncn1)O2
CHEMBL88152 5ht1d_human Human No 8.0 IC50 = 10 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
298 7 2 5 2.3 c1ccc2c(c1)CCC(CNCCCNc1cnccn1)O2
CHEMBL88784 5ht1d_human Human No 8.0 IC50 = 10 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
330 8 3 5 2.1 c1ccc2c(c1)CCC(CNCCCCCNC1=NCCCN1)O2
CHEMBL314213 5ht1d_rat Rat No 8.0 IC50 = 10 nM Bind
Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor
325 6 2 5 3.3 CN(C)CCc1c[nH]c2ccc(Nc3ncccc3[N+](=O)[O-])cc12
CHEMBL147071 5ht1d_human Human Yes 8.0 IC50 = 10 nM Bind
Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay
458 6 2 5 3.8 COc1ccc(NC(=O)c2ccc(-c3ccc(C(N)=O)cc3C)cc2)cc1N1CCN(C)CC1
CHEMBL128 5ht1d_human Human Yes 7.0 IC50 = 100 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL2110300 5ht1d_human Human No 7.0 IC50 = 100 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
313 4 2 3 2.6 CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1
CHEMBL2368257 5ht1d_human Human No 7.0 IC50 = 100 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
327 4 1 3 3.0 CN1C(=O)OCC1Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1
CHEMBL274922 5ht1d_rat Rat No 7.0 IC50 = 100 nM Bind
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
490 5 3 5 3.4 COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(C(N)=O)cc34)CC2)cc1N1CCN(C)CC1
CHEMBL326723 5ht1d_human Human No 8.0 IC50 = 11 nM Bind
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
501 10 4 7 3.3 CC(=O)Nc1ccc(CNCC2(O)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL423022 5ht1d_human Human No 8.0 IC50 = 11 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
458 9 3 6 3.9 C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@H](O)c1ccccc1
CHEMBL905 5ht1d_human Human Yes 8.0 IC50 = 11 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C
CHEMBL80189 5ht1d_human Human No 8.0 IC50 = 11 nM Bind
Tested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligandTested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligand
305 4 1 4 3.0 CN(C)CCc1c[nH]c2ccc(-n3cnc4cccnc43)cc12
CHEMBL27173 5ht1d_human Human No 7.0 IC50 = 110 nM Bind
Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand
216 2 2 2 2.0 NCCc1c[nH]c2ccc3c(c12)CCCO3
CHEMBL143723 5ht1d_human Human No 7.0 IC50 = 110 nM Bind
Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.
322 8 1 2 4.6 CCN(CC)CCc1c[nH]c2ccc(OCc3ccccc3)cc12
CHEMBL143723 5ht1d_human Human No 7.0 IC50 = 110 nM Bind
Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells
322 8 1 2 4.6 CCN(CC)CCc1c[nH]c2ccc(OCc3ccccc3)cc12
CHEMBL143890 5ht1d_human Human No 7.9 IC50 = 12 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
458 9 3 6 3.9 C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](O)c1ccccc1
CHEMBL349390 5ht1d_human Human No 7.9 IC50 = 12 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
457 9 3 6 3.4 CC(=O)Nc1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL143951 5ht1d_human Human No 7.9 IC50 = 12 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
324 5 2 5 2.1 NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL146023 5ht1d_human Human No 7.9 IC50 = 12 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
485 10 3 6 3.9 CC(=O)Nc1ccc(CCNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL91534 5ht1d_human Human No 7.9 IC50 = 12 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
446 8 1 5 4.2 CN(Cc1ccccc1)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@H]1F
CHEMBL431211 5ht1d_human Human No 7.9 IC50 = 12.6 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
316 7 3 5 1.7 c1ccc2c(c1)CCC(CNCCCCNC1=NCCCN1)O2
CHEMBL122860 5ht1d_human Human No 5.9 IC50 = 1200 nM Bind
Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand
244 3 1 2 2.6 CN(C)CCc1c[nH]c2cc3c(cc12)OCCC3
CHEMBL91154 5ht1d_human Human No 6.9 IC50 = 125.9 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
288 6 3 5 0.9 c1ccc2c(c1)CC(CNCCCNC1=NCCCN1)O2
CHEMBL92207 5ht1d_human Human No 7.9 IC50 = 13 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
446 8 1 5 4.2 CN(Cc1ccccc1)[C@@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]1F
CHEMBL2114039 5ht1d_human Human No 7.9 IC50 = 13 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
514 8 1 5 5.2 CN(Cc1ccccc1C(F)(F)F)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]1F
CHEMBL2115111 5ht1d_human Human No 7.9 IC50 = 13 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
500 8 2 5 4.9 F[C@@H]1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC[C@@H]1NCc1ccccc1C(F)(F)F
CHEMBL100875 5ht1d_human Human No 4.9 IC50 = 13000 nM Bind
Inhibitory concentration required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HTInhibitory concentration required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT
394 4 1 5 3.4 OC1(c2ccc3c(c2)OCO3)CCC(N2CCN(Cc3ccccc3)CC2)CC1
CHEMBL324931 5ht1d_human Human No 6.9 IC50 = 134 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
310 4 1 5 1.5 CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL315772 5ht1d_human Human No 6.9 IC50 = 134.9 nM Bind
Binding affinity against 5-HT1D receptorBinding affinity against 5-HT1D receptor
328 2 0 3 4.1 CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1
CHEMBL315772 5ht1d_human Human No 6.9 IC50 = 134.9 nM Bind
Binding affinity for human cloned 5-hydroxytryptamine 1D receptorBinding affinity for human cloned 5-hydroxytryptamine 1D receptor
328 2 0 3 4.1 CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1
CHEMBL145997 5ht1d_human Human No 7.9 IC50 = 14 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
415 8 2 6 3.3 c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1
CHEMBL2368254 5ht1d_human Human No 7.8 IC50 = 14.5 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
278 3 2 2 4.2 N[C@H]1C[C@H](c2c[nH]c3ccc(Oc4ccccc4)cc32)C1
CHEMBL158638 5ht1d_human Human No 7.8 IC50 = 14.8 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
257 3 2 2 2.1 CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(C(N)=O)cc32)C1
CHEMBL324931 5ht1d_human Human No 6.9 IC50 = 140 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
310 4 1 5 1.5 CN1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL267615 5ht1d_human Human Yes 5.9 IC50 = 1400 nM Bind
Inhibitory activity against 5-hydroxytryptamine 1D receptor in calfInhibitory activity against 5-hydroxytryptamine 1D receptor in calf
246 5 1 2 2.8 CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC
CHEMBL159470 5ht1d_human Human No 6.9 IC50 = 141.3 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
347 5 2 2 3.9 CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(C(=O)NCc4ccccc4)cc32)C1
CHEMBL2368262 5ht1d_human Human No 5.8 IC50 = 1479.1 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
368 5 2 3 2.8 CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CCN4C(=O)NC(C)(C)C4=O)cc32)C1
CHEMBL148071 5ht1d_human Human No 7.8 IC50 = 15 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
521 11 3 7 3.0 CS(=O)(=O)NC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL84942 5ht1d_rat Rat Yes 7.8 IC50 = 15 nM Bind
Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor
337 4 2 5 3.6 CN1CCC(c2c[nH]c3ccc(Nc4ncccc4[N+](=O)[O-])cc23)C1
CHEMBL305301 5ht1d_human Human No 7.8 IC50 = 15 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
468 8 1 5 3.9 Fc1cccc(CCN2CCN(CC(F)(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL88212 5ht1d_human Human No 7.8 IC50 = 15.9 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
302 6 3 5 1.3 c1ccc2c(c1)CC[C@@H](CNCCCNC1=NCCCN1)O2
CHEMBL2110300 5ht1d_human Human No 7.8 IC50 = 15.9 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
313 4 2 3 2.6 CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1
CHEMBL18710 5ht1d_human Human No 6.8 IC50 = 151.4 nM Bind
In Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudateIn Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudate
232 4 1 3 1.6 CN(C)CCc1coc2ccc(C(N)=O)cc12
CHEMBL90981 5ht1d_human Human No 6.8 IC50 = 158.5 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
330 6 3 5 1.2 O=C1CCCN=C(NCCCNCC2CCc3ccccc3O2)N1
CHEMBL16035 5ht1d_rat Rat No 6.8 IC50 = 167 nM Bind
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
425 6 3 4 3.4 COc1ccc(NC(=O)NCCc2c[nH]c3ccc(F)cc23)cc1N1CCN(C)CC1
CHEMBL2110300 5ht1d_human Human No 6.8 IC50 = 169.8 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
313 4 2 3 2.6 CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1
CHEMBL162296 5ht1d_human Human No 7.8 IC50 = 17 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
350 8 2 5 2.4 C=CCNC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1
CHEMBL347570 5ht1d_human Human No 7.8 IC50 = 17 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
513 9 2 6 4.1 CC(=O)Nc1ccc(C(=O)N(C)CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL143967 5ht1d_human Human No 6.8 IC50 = 170 nM Bind
Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.
392 9 1 4 4.1 CCCN(CCC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12
CHEMBL161969 5ht1d_human Human No 6.8 IC50 = 173 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
414 7 1 5 3.0 O=C1CN(Cc2ccccc2)CCN1CCCc1c[nH]c2ccc(-n3cnnc3)cc12
CHEMBL144002 5ht1d_human Human No 7.8 IC50 = 18 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
428 8 2 5 4.5 C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1
CHEMBL147555 5ht1d_human Human No 7.8 IC50 = 18 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
506 9 1 7 3.7 CN(Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL148325 5ht1d_human Human No 7.8 IC50 = 18 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
457 7 2 5 4.3 CN(C(=O)Nc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL149488 5ht1d_human Human No 7.7 IC50 = 19 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
485 9 2 6 4.2 CC(=O)Nc1ccc(CN(C)C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL28178 5ht1d_human Human No 6.7 IC50 = 190 nM Bind
Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand
320 1 1 4 2.9 FC(F)(F)c1ccc2c(c1)nc(N1CCNCC1)c1cccn12
CHEMBL2368259 5ht1d_human Human No 6.7 IC50 = 190.6 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
321 5 2 3 2.0 CNS(=O)(=O)Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1
CHEMBL2368261 5ht1d_human Human No 6.7 IC50 = 195.0 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
387 5 1 3 3.8 CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CCN4C(=O)c5ccccc5C4=O)cc32)C1
CHEMBL293678 5ht1d_human Human No 8.7 IC50 = 2 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
431 8 1 4 5.1 FC1(CCc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL146131 5ht1d_human Human No 8.7 IC50 = 2.1 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
458 10 3 6 3.3 OC[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL161735 5ht1d_human Human No 8.7 IC50 = 2.1 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
415 9 1 5 4.2 c1ccc(COC[C@@H]2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL304857 5ht1d_human Human No 8.7 IC50 = 2.1 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
428 8 1 5 4.3 CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL2114040 5ht1d_human Human No 8.7 IC50 = 2.1 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
446 8 1 5 4.2 CN(Cc1ccccc1)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@@H]1F
CHEMBL304857 5ht1d_human Human No 8.7 IC50 = 2.1 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
428 8 1 5 4.3 CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL304857 5ht1d_human Human No 8.7 IC50 = 2.2 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
428 8 1 5 4.3 CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL304857 5ht1d_human Human No 8.7 IC50 = 2.2 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
428 8 1 5 4.3 CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL91534 5ht1d_human Human No 8.7 IC50 = 2.2 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
446 8 1 5 4.2 CN(Cc1ccccc1)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@H]1F
CHEMBL326371 5ht1d_human Human No 8.6 IC50 = 2.3 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
401 8 1 5 3.8 c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL163462 5ht1d_human Human No 8.6 IC50 = 2.3 nM Bind
Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
443 8 2 6 2.5 NC(=O)C(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL326371 5ht1d_human Human No 8.6 IC50 = 2.3 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
401 8 1 5 3.8 c1ccc(COC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL424154 5ht1d_human Human No 8.6 IC50 = 2.5 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
428 9 2 5 4.0 C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1)c1ccccc1
CHEMBL163127 5ht1d_human Human No 8.6 IC50 = 2.5 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
457 8 2 6 3.5 CC(=O)Nc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL88240 5ht1d_human Human Yes 8.6 IC50 = 2.5 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
302 6 3 5 1.3 C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1
CHEMBL348815 5ht1d_human Human No 8.6 IC50 = 2.6 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
414 9 2 5 3.4 c1ccc(CCNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL357007 5ht1d_human Human No 8.6 IC50 = 2.6 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
420 9 1 5 4.4 CC(C)=CCCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL281575 5ht1d_human Human No 8.6 IC50 = 2.6 nM Bind
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
648 17 6 4 7.7 NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1
CHEMBL1185 5ht1d_human Human Yes 8.6 IC50 = 2.8 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C
CHEMBL128 5ht1d_human Human Yes 8.5 IC50 = 3.0 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL435060 5ht1d_human Human No 7.7 IC50 = 20 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
387 7 1 5 3.6 c1ccc(CO[C@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL148286 5ht1d_human Human No 7.7 IC50 = 20 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
378 8 1 5 3.3 C=CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL277452 5ht1d_human Human No 7.7 IC50 = 20.3 nM Bind
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
564 11 6 4 5.4 NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1
CHEMBL330803 5ht1d_human Human No 6.7 IC50 = 200 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
295 4 1 4 2.8 c1cc2[nH]cc(CCN3CCCCC3)c2cc1-n1cnnc1
CHEMBL15139 5ht1d_rat Rat No 6.7 IC50 = 200 nM Bind
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
423 6 4 5 3.0 COc1ccc(NC(=O)NCCc2c[nH]c3ccc(O)cc23)cc1N1CCN(C)CC1
CHEMBL15965 5ht1d_rat Rat No 6.7 IC50 = 200 nM Bind
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
508 7 3 5 4.1 COc1ccc(NC(=O)NCCN2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1N1CCN(C)CC1
CHEMBL278917 5ht1d_rat Rat No 6.7 IC50 = 200 nM Bind
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
465 4 2 4 4.5 COc1ccc(NC(=O)N2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1N1CCN(C)CC1
CHEMBL280000 5ht1d_rat Rat No 6.7 IC50 = 200 nM Bind
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
475 6 2 4 4.8 COc1ccc(NC(=O)N2CCC(CCc3c[nH]c4ccccc34)CC2)cc1N1CCN(C)CC1
CHEMBL330803 5ht1d_human Human No 6.7 IC50 = 200 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
295 4 1 4 2.8 c1cc2[nH]cc(CCN3CCCCC3)c2cc1-n1cnnc1
CHEMBL159536 5ht1d_human Human No 5.7 IC50 = 2041.7 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
309 4 2 3 3.0 Cc1nc(Cc2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n[nH]1
CHEMBL115496 5ht1d_human Human Yes 7.7 IC50 = 21 nM Bind
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
454 7 3 7 3.0 CC(C)(C)OC(=O)NCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL143510 5ht1d_human Human No 7.7 IC50 = 21 nM Bind
Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.
364 7 1 4 3.3 CCN(CC)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12
CHEMBL422191 5ht1d_human Human No 6.7 IC50 = 210 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
338 6 1 5 2.3 CN1CCN(CCCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL147786 5ht1d_human Human No 7.7 IC50 = 22 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
392 8 1 5 3.5 CN(CC1CC1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL412876 5ht1d_human Human Yes 6.7 IC50 = 220 nM Bind
Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand
244 3 1 2 2.6 CN(C)CCc1c[nH]c2ccc3c(c12)CCCO3
CHEMBL304008 5ht1d_human Human Yes 5.7 IC50 = 2200 nM Bind
Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand
215 1 3 2 1.2 O=c1ccc2c([nH]1)c(c[nH]2)C1=CCNCC1
CHEMBL420874 5ht1d_human Human No 7.6 IC50 = 23 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
387 7 1 5 3.6 c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL341854 5ht1d_human Human No 7.6 IC50 = 23 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
458 10 3 6 3.5 OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccccc1
CHEMBL15855 5ht1d_rat Rat No 6.6 IC50 = 233 nM Bind
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
447 4 2 4 4.3 COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccccc34)CC2)cc1N1CCN(C)CC1
CHEMBL2079627 5ht1d_rat Rat No 6.6 IC50 = 233 nM Bind
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
465 4 2 4 4.5 COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(F)cc34)CC2)cc1N1CCN(C)CC1
CHEMBL279646 5ht1d_rat Rat No 6.6 IC50 = 233 nM Bind
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
451 4 2 4 4.1 COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(F)cc34)C2)cc1N1CCN(C)CC1
CHEMBL137485 5ht1d_cavpo Guinea pig No 7.6 IC50 = 24 nM Bind
Binding affinity against 5-hydroxytryptamine 1D receptorBinding affinity against 5-hydroxytryptamine 1D receptor
244 3 1 2 2.8 COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1
CHEMBL331612 5ht1d_human Human No 7.6 IC50 = 24 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
309 5 1 4 3.2 c1cc2[nH]cc(CCCN3CCCCC3)c2cc1-n1cnnc1
CHEMBL146729 5ht1d_human Human No 7.6 IC50 = 24 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
415 8 2 6 3.3 c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)ccn1
CHEMBL331612 5ht1d_human Human No 7.6 IC50 = 24 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
309 5 1 4 3.2 c1cc2[nH]cc(CCCN3CCCCC3)c2cc1-n1cnnc1
CHEMBL128 5ht1d_human Human Yes 5.6 IC50 = 2400 nM Bind
Compound was evaluated for the affinity at 5-hydroxytryptamine 1D receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1D receptor
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL2368258 5ht1d_human Human No 5.6 IC50 = 2454.7 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
326 4 2 3 2.0 CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CN4C(=O)CNC4=O)cc32)C1
CHEMBL357130 5ht1d_human Human Yes 7.6 IC50 = 25 nM Bind
Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells
294 6 1 2 3.9 CN(C)CCc1c[nH]c2ccc(OCc3ccccc3)cc12
CHEMBL89448 5ht1d_human Human No 7.6 IC50 = 25.1 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
304 6 3 6 0.7 c1ccc2c(c1)OCC(CNCCCNC1=NCCCN1)O2
CHEMBL159627 5ht1d_human Human No 7.6 IC50 = 26 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
311 5 2 5 1.6 OC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1
CHEMBL51 5ht1d_human Human Yes 6.6 IC50 = 260 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2
CHEMBL278610 5ht1d_human Human No 7.6 IC50 = 27.3 nM Bind
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
550 10 6 4 5.0 NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1
CHEMBL51 5ht1d_human Human Yes 6.6 IC50 = 270 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2
CHEMBL3084967 5ht1d_human Human No 7.5 IC50 = 28.8 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
327 5 2 3 2.7 CN(C)[C@H]1C[C@H](Cc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1
CHEMBL303997 5ht1d_human Human No 6.6 IC50 = 280 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
451 8 1 5 4.7 FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(COc2ccccc2)CC1
CHEMBL146150 5ht1d_human Human No 7.5 IC50 = 29 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
485 9 3 6 4.5 CC(=O)Nc1ccc([C@@H](C)NC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL39 5ht1d_cavpo Guinea pig Yes 8.5 IC50 = 3 nM Bind
Binding affinity against 5-hydroxytryptamine 1D receptorBinding affinity against 5-hydroxytryptamine 1D receptor
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL145815 5ht1d_human Human No 8.5 IC50 = 3 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
458 10 2 6 4.1 COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL39 5ht1d_rat Rat Yes 8.5 IC50 = 3 nM Bind
Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL146335 5ht1d_human Human No 8.5 IC50 = 3 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
471 9 3 6 3.9 CC(=O)Nc1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL147503 5ht1d_human Human Yes 8.5 IC50 = 3 nM Bind
Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay
457 6 3 5 4.0 COc1ccc(NC(=O)c2ccc(-c3ccc(C(=N)N)cc3C)cc2)cc1N1CCN(C)CC1
CHEMBL39 5ht1d_human Human Yes 8.5 IC50 = 3 nM Bind
Inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandInhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht1d_human Human Yes 8.5 IC50 = 3 nM Bind
Tested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligandTested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligand
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL83597 5ht1d_rat Rat Yes 8.5 IC50 = 3.1 nM Bind
Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor
351 5 2 5 3.9 CN1CCC[C@@H]1Cc1c[nH]c2ccc(Nc3ncccc3[N+](=O)[O-])cc12
CHEMBL116092 5ht1d_human Human No 8.5 IC50 = 3.1 nM Bind
Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
281 4 1 4 2.4 c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1
CHEMBL116092 5ht1d_human Human No 8.5 IC50 = 3.1 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
281 4 1 4 2.4 c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1
CHEMBL116092 5ht1d_human Human No 8.5 IC50 = 3.1 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
281 4 1 4 2.4 c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1
CHEMBL88676 5ht1d_human Human Yes 8.5 IC50 = 3.2 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
302 6 3 5 1.3 c1ccc2c(c1)CCC(CNCCCNC1=NCCCN1)O2
CHEMBL90443 5ht1d_human Human No 8.5 IC50 = 3.2 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
319 8 4 4 1.2 CC(C)/N=C(\N)NNCCCNCC1CCc2ccccc2O1
CHEMBL91596 5ht1d_human Human No 8.5 IC50 = 3.2 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
332 7 3 6 1.3 COc1ccc2c(c1)OC(CNCCCNC1=NCCCN1)CC2
CHEMBL112558 5ht1d_human Human No 8.5 IC50 = 3.2 nM Bind
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
445 9 3 7 2.7 OC1(CNCc2ccccn2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL161192 5ht1d_human Human No 8.5 IC50 = 3.2 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
414 9 2 5 3.5 c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(Cn5cncn5)cc34)C2)cc1
CHEMBL310061 5ht1d_human Human No 8.5 IC50 = 3.3 nM Bind
Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)
424 7 1 5 4.2 CN1C[C@@H](CN(C#N)Cc2ccccc2)C[C@@H]1Cc1c[nH]c2ccc(-n3ccnc3)cc12
CHEMBL17828 5ht1d_human Human No 8.5 IC50 = 3.4 nM Bind
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
578 12 6 4 5.8 NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1
CHEMBL18840 5ht1d_human Human Yes 8.5 IC50 = 3.4 nM Bind
In Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudateIn Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudate
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL116092 5ht1d_human Human No 8.5 IC50 = 3.4 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
281 4 1 4 2.4 c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1
CHEMBL146265 5ht1d_human Human No 8.5 IC50 = 3.4 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
458 10 3 6 3.7 OC[C@@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL116092 5ht1d_human Human No 8.5 IC50 = 3.4 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
281 4 1 4 2.4 c1cc2[nH]cc(CCN3CCCC3)c2cc1-n1cnnc1
CHEMBL146132 5ht1d_human Human No 8.5 IC50 = 3.5 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
444 9 3 6 3.5 OC[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL63432 5ht1d_human Human No 8.5 IC50 = 3.5 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
450 8 1 5 3.6 Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL349893 5ht1d_human Human No 8.4 IC50 = 3.6 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
401 8 2 6 2.8 c1ccc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)nc1
CHEMBL2110299 5ht1d_human Human No 8.4 IC50 = 3.6 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
285 3 3 3 2.0 N[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1
CHEMBL63432 5ht1d_human Human No 8.4 IC50 = 3.7 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
450 8 1 5 3.6 Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL345657 5ht1d_human Human No 8.4 IC50 = 3.8 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
401 8 2 6 2.8 c1cncc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)c1
CHEMBL91123 5ht1d_human Human No 8.4 IC50 = 4.0 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
301 6 2 4 2.5 c1ccc2c(c1)CCC(CNCCCNC1=NCCCC1)O2
CHEMBL305062 5ht1d_human Human No 7.5 IC50 = 30 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
433 8 1 5 4.3 FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1
CHEMBL15961 5ht1d_rat Rat No 6.5 IC50 = 300 nM Bind
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
465 4 2 4 4.5 COc1ccc(NC(=O)N2CCC(c3c[nH]c4cccc(F)c34)CC2)cc1N1CCN(C)CC1
CHEMBL84931 5ht1d_human Human No 6.5 IC50 = 302 nM Bind
Binding affinity for human cloned 5-hydroxytryptamine 1D receptorBinding affinity for human cloned 5-hydroxytryptamine 1D receptor
312 2 0 3 3.5 CN(C)CC1CC2c3ccccc3Cc3ccc(F)cc3N2O1
CHEMBL2368260 5ht1d_human Human No 5.5 IC50 = 3090.3 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
354 4 2 3 2.8 CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CN4C(=O)NC(C)(C)C4=O)cc32)C1
CHEMBL274001 5ht1d_human Human No 7.5 IC50 = 31 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
310 5 2 5 1.6 c1cc2[nH]cc(CCCN3CCNCC3)c2cc1-n1cnnc1
CHEMBL313490 5ht1d_human Human No 7.5 IC50 = 31.6 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
284 6 2 5 1.9 c1cnc(NCCNCC2CCc3ccccc3O2)nc1
CHEMBL117249 5ht1d_human Human No 7.5 IC50 = 33 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
324 5 1 5 1.9 CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL350277 5ht1d_human Human No 6.5 IC50 = 338.8 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
361 6 2 2 3.8 CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC(=O)NCc4ccccc4)cc32)C1
CHEMBL27403 5ht1d_human Human Yes 7.5 IC50 = 35 nM Bind
Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand
334 1 0 4 3.3 CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F
CHEMBL146891 5ht1d_human Human No 7.5 IC50 = 35 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
415 8 2 6 3.3 c1cncc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL117249 5ht1d_human Human No 7.5 IC50 = 35 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
324 5 1 5 1.9 CN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL67367 5ht1d_human Human No 7.5 IC50 = 35 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
464 8 1 5 4.5 CN(Cc1ccccc1)C1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL15837 5ht1d_rat Rat No 6.4 IC50 = 367 nM Bind
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
522 8 2 5 4.2 COc1ccc(NC(=O)N2CCN(CCCCc3c[nH]c4ccc(F)cc34)CC2)cc1N1CCN(C)CC1
CHEMBL324287 5ht1d_human Human No 7.4 IC50 = 37 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
400 7 1 5 3.5 CN(Cc1ccccc1)[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1
CHEMBL143894 5ht1d_human Human No 7.4 IC50 = 37 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
456 7 3 6 3.4 O[C@H]1Cc2ccccc2C1NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL146735 5ht1d_human Human Yes 7.4 IC50 = 37 nM Bind
Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay
497 6 1 7 5.0 COc1ccc(NC(=O)c2ccc(-c3ccc(-c4nnc(C)o4)cc3C)cc2)cc1N1CCN(C)CC1
CHEMBL324287 5ht1d_human Human No 7.4 IC50 = 38 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
400 7 1 5 3.5 CN(Cc1ccccc1)[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1
CHEMBL6437 5ht1d_human Human Yes 6.4 IC50 = 380.2 nM Bind
Binding affinity for human cloned 5-hydroxytryptamine 1D receptorBinding affinity for human cloned 5-hydroxytryptamine 1D receptor
264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1
CHEMBL18785 5ht1d_human Human Yes 7.4 IC50 = 39 nM Bind
Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand
228 2 2 2 2.6 COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1
CHEMBL314738 5ht1d_human Human No 7.4 IC50 = 39.8 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
300 6 3 4 1.7 c1ccc2c(c1)CCC(CNCCCNC1=NCCCN1)C2
CHEMBL128 5ht1d_human Human Yes 7.4 IC50 = 39.8 nM Bind
Binding activity radioligand.Binding activity radioligand.
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL324751 5ht1d_human Human No 8.4 IC50 = 4 nM Bind
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
458 9 3 6 3.6 Cc1ccccc1CNCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL147961 5ht1d_human Human No 8.4 IC50 = 4.1 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
444 9 3 6 3.5 OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cncn4)cc23)CC1)c1ccccc1
CHEMBL159650 5ht1d_human Human No 8.4 IC50 = 4.2 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
428 9 1 5 4.1 CN(Cc1ccccc1)C[C@@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C1
CHEMBL147907 5ht1d_human Human No 8.4 IC50 = 4.2 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
427 8 2 4 5.1 C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4ccnc4)cc23)CC1)c1ccccc1
CHEMBL147940 5ht1d_human Human No 8.4 IC50 = 4.2 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
485 10 3 6 4.1 CC(=O)Nc1ccc(CNCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL342330 5ht1d_human Human No 8.4 IC50 = 4.3 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
458 9 2 6 3.8 CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@H](CO)c1ccccc1
CHEMBL423212 5ht1d_human Human No 8.4 IC50 = 4.3 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
434 8 1 6 4.3 CN(Cc1cccs1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL146391 5ht1d_human Human No 8.4 IC50 = 4.4 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
442 9 2 5 4.7 C[C@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL331143 5ht1d_human Human No 8.4 IC50 = 4.5 nM Bind
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
408 9 3 6 2.5 OC1(CNCC2CC2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL423749 5ht1d_human Human No 8.4 IC50 = 4.5 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
458 9 2 6 3.8 CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](CO)c1ccccc1
CHEMBL357408 5ht1d_human Human No 8.4 IC50 = 4.5 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
404 8 2 6 3.5 c1cc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)co1
CHEMBL117046 5ht1d_human Human No 8.3 IC50 = 4.6 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
414 8 2 5 3.9 c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL342805 5ht1d_human Human No 8.3 IC50 = 4.7 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
487 10 3 7 3.6 NC(=O)OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL292262 5ht1d_human Human No 8.3 IC50 = 4.7 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
450 8 1 5 3.6 Fc1ccccc1CCN1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL117046 5ht1d_human Human No 8.3 IC50 = 4.8 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
414 8 2 5 3.9 c1ccc(CNC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL351311 5ht1d_human Human No 8.3 IC50 = 4.9 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
415 8 1 6 2.9 c1cncc(CCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL352123 5ht1d_human Human No 8.3 IC50 = 4.9 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
428 9 1 5 3.9 c1ccc(CCCN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL430122 5ht1d_rat Rat No 6.4 IC50 = 400 nM Bind
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
472 4 2 5 4.2 COc1ccc(NC(=O)N2CCC(c3c[nH]c4ccc(C#N)cc34)CC2)cc1N1CCN(C)CC1
CHEMBL359447 5ht1d_human Human Yes 6.4 IC50 = 400 nM Bind
Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay
483 5 2 7 4.7 Cc1nnc(-c2ccc(-c3ccc(C(=O)Nc4ccc(O)c(N5CCN(C)CC5)c4)cc3)c(C)c2)o1
CHEMBL439849 5ht1d_rat Rat Yes 5.4 IC50 = 4000 nM Bind
Inhibition of rat hydroxytryptamine 1D receptorInhibition of rat hydroxytryptamine 1D receptor
441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2
CHEMBL19114 5ht1d_human Human No 7.4 IC50 = 42.7 nM Bind
In Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudateIn Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudate
204 3 2 3 1.0 NCCc1coc2ccc(C(N)=O)cc12
CHEMBL133939 5ht1d_cavpo Guinea pig No 6.4 IC50 = 420 nM Bind
Binding affinity against 5-hydroxytryptamine 1D receptorBinding affinity against 5-hydroxytryptamine 1D receptor
244 3 1 2 2.8 COc1ccc2[nH]cc(C[C@@H]3CCCN3C)c2c1
CHEMBL25800 5ht1d_human Human Yes 5.4 IC50 = 4200 nM Bind
Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand
230 2 1 3 2.0 Cn1cc(CCN)c2c3c(ccc21)OCCC3
CHEMBL341897 5ht1d_human Human No 7.4 IC50 = 43 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
468 10 3 4 4.0 CNS(=O)(=O)Cc1ccc2[nH]cc(CCCN3CCC(N[C@H](C)c4ccccc4)CC3)c2c1
CHEMBL279320 5ht1d_rat Rat No 6.4 IC50 = 433 nM Bind
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
497 10 3 5 4.3 COc1ccc(NC(=O)NCCN2CCC(c3c[nH]c4cc(F)ccc34)CC2)cc1OCCN(C)C
CHEMBL470432 5ht1d_rat Rat No 5.3 IC50 = 4570.9 nM Bind
Displacement of [3H]5OH-tryptamine rat recombinant 5HT1D receptorDisplacement of [3H]5OH-tryptamine rat recombinant 5HT1D receptor
343 5 0 5 4.4 CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1
CHEMBL422504 5ht1d_human Human No 6.3 IC50 = 467 nM Bind
Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay
483 5 2 7 4.7 Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc(O)c(N5CCN(C)CC5)c4)cc3)c(C)c2)no1
CHEMBL143745 5ht1d_human Human No 6.3 IC50 = 470 nM Bind
Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.
350 10 1 2 5.4 CCCN(CCC)CCc1c[nH]c2ccc(OCc3ccccc3)cc12
CHEMBL143745 5ht1d_human Human No 6.3 IC50 = 470 nM Bind
Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells
350 10 1 2 5.4 CCCN(CCC)CCc1c[nH]c2ccc(OCc3ccccc3)cc12
CHEMBL334923 5ht1d_human Human No 6.3 IC50 = 478.6 nM Bind
Compound was tested for binding affinity against 5-hydroxytryptamine 1D receptorCompound was tested for binding affinity against 5-hydroxytryptamine 1D receptor
275 4 0 5 2.5 Cc1csc2c1-n1cccc1/C2=N/OCCN(C)C
CHEMBL7257 5ht1d_cavpo Guinea pig Yes 7.3 IC50 = 49 nM Bind
Binding affinity against 5-hydroxytryptamine 1D receptorBinding affinity against 5-hydroxytryptamine 1D receptor
218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL7257 5ht1d_human Human Yes 7.3 IC50 = 49 nM Bind
Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand
218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL128 5ht1d_human Human Yes 8.3 IC50 = 5 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL344537 5ht1d_human Human No 8.3 IC50 = 5 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
490 11 2 6 4.3 COC[C@H](NC1CCN(CCCc2c[nH]c3ccc(Cn4cncn4)cc23)CC1)c1ccc(F)cc1
CHEMBL128 5ht1d_human Human Yes 8.3 IC50 = 5 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL2114038 5ht1d_human Human No 8.3 IC50 = 5 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
500 8 2 5 4.9 F[C@H]1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC[C@@H]1NCc1ccccc1C(F)(F)F
CHEMBL88207 5ht1d_human Human No 8.3 IC50 = 5.0 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
297 7 2 4 2.9 c1ccc(NCCCNCC2CCc3ccccc3O2)nc1
CHEMBL63432 5ht1d_human Human No 8.3 IC50 = 5.1 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
450 8 1 5 3.6 Fc1cccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL148194 5ht1d_human Human No 8.3 IC50 = 5.2 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
458 9 3 6 3.6 CC(CO)(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL163376 5ht1d_human Human No 8.3 IC50 = 5.2 nM Bind
Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
468 7 1 5 4.5 FC(F)(F)c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL161970 5ht1d_human Human No 8.3 IC50 = 5.2 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
428 8 1 5 3.1 O=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1CCc1ccccc1
CHEMBL416688 5ht1d_human Human No 8.3 IC50 = 5.4 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
446 8 1 5 4.2 CN(Cc1ccccc1)C1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL416688 5ht1d_human Human No 8.3 IC50 = 5.4 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
446 8 1 5 4.2 CN(Cc1ccccc1)C1CCN(CC(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL146502 5ht1d_human Human No 8.3 IC50 = 5.5 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
442 9 2 5 4.4 C[C@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL146628 5ht1d_human Human No 8.3 IC50 = 5.5 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
458 10 3 6 3.9 OCCC(NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL303514 5ht1d_human Human No 8.3 IC50 = 5.5 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
450 8 1 5 3.6 Fc1ccc(CCN2CCN(CC(F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL147546 5ht1d_human Human No 8.2 IC50 = 5.7 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
499 10 2 6 4.3 CC(=O)Nc1ccc(CCN(C)C2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1
CHEMBL2114036 5ht1d_human Human No 8.2 IC50 = 5.8 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
450 8 1 5 3.6 Fc1cccc(CCN2CCN(C[C@@H](F)Cc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1
CHEMBL147148 5ht1d_human Human No 8.2 IC50 = 5.9 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
471 8 2 5 4.6 CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)C(=O)Nc1ccccc1
CHEMBL147979 5ht1d_human Human No 8.2 IC50 = 5.9 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
458 10 3 6 3.7 OC[C@H](NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL312845 5ht1d_human Human No 7.3 IC50 = 50.1 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
329 7 3 4 1.8 CC(C)/N=C(\NC#N)NCCCNCC1CCc2ccccc2O1
CHEMBL2368255 5ht1d_human Human No 6.3 IC50 = 501.2 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
340 4 3 3 2.2 CC1(C)NC(=O)N(CCc2ccc3[nH]cc([C@H]4C[C@H](N)C4)c3c2)C1=O
CHEMBL15928 5ht1d_human Human Yes 7.3 IC50 = 52 nM Bind
Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay
497 6 1 7 5.0 COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C
CHEMBL15928 5ht1d_rat Rat Yes 7.3 IC50 = 53 nM Bind
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
497 6 1 7 5.0 COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C
CHEMBL68019 5ht1d_human Human No 7.3 IC50 = 56 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
449 8 1 4 5.3 FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(CCc2ccccc2)CC1
CHEMBL350637 5ht1d_human Human No 6.3 IC50 = 562.3 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
296 3 1 4 3.3 Cc1noc(-c2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n1
CHEMBL2368257 5ht1d_human Human No 7.2 IC50 = 57.5 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
327 4 1 3 3.0 CN1C(=O)OCC1Cc1ccc2[nH]cc([C@H]3C[C@H](N(C)C)C3)c2c1
CHEMBL145849 5ht1d_human Human No 8.2 IC50 = 6 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
472 10 2 6 4.1 CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)[C@@H](CO)c1ccccc1
CHEMBL84107 5ht1d_rat Rat No 8.2 IC50 = 6.2 nM Bind
Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor
337 5 3 5 3.5 O=[N+]([O-])c1cccnc1Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1
CHEMBL143952 5ht1d_human Human No 8.2 IC50 = 6.2 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
478 9 2 6 3.4 O=S(=O)(NCC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL433108 5ht1d_human Human No 8.2 IC50 = 6.2 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
464 8 1 5 4.3 CC(CN1CCN(CC(F)(F)Cc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL420874 5ht1d_human Human No 8.2 IC50 = 6.3 nM Bind
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
387 7 1 5 3.6 c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL420874 5ht1d_human Human No 8.2 IC50 = 6.3 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
387 7 1 5 3.6 c1ccc(CO[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL146129 5ht1d_human Human No 8.2 IC50 = 6.3 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
476 10 4 5 3.5 O=C1N[C@@H](Cc2ccc3[nH]cc(CCCN4CCC(N[C@@H](CO)c5ccccc5)CC4)c3c2)CO1
CHEMBL88208 5ht1d_human Human No 8.2 IC50 = 6.3 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
288 6 3 5 0.9 c1ccc2c(c1)CCC(CNCCCNC1=NCCN1)O2
CHEMBL2112862 5ht1d_human Human No 8.2 IC50 = 6.6 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
456 7 3 6 3.4 O[C@@H]1Cc2ccccc2[C@H]1NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL162899 5ht1d_human Human No 8.2 IC50 = 6.6 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
414 7 1 5 3.0 O=C1CN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CCN1Cc1ccccc1
CHEMBL128 5ht1d_human Human Yes 8.2 IC50 = 6.7 nM Bind
Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL128 5ht1d_human Human Yes 8.2 IC50 = 6.7 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL128 5ht1d_human Human Yes 8.2 IC50 = 6.8 nM Bind
Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells.Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells.
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL304993 5ht1d_human Human No 8.2 IC50 = 6.8 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
432 8 1 5 3.5 FC(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCN(CCc2ccccc2)CC1
CHEMBL163114 5ht1d_human Human No 8.2 IC50 = 6.9 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
496 9 1 8 3.9 Cc1noc(-c2ccc(CCN3CCN(CCCc4c[nH]c5ccc(-n6cnnc6)cc45)CC3)cc2)n1
CHEMBL159174 5ht1d_cavpo Guinea pig Yes 7.2 IC50 = 60 nM Bind
Binding affinity towards guinea pig 5-hydroxytryptamine 1D receptor was determinedBinding affinity towards guinea pig 5-hydroxytryptamine 1D receptor was determined
453 11 6 6 0.1 NCCc1c[nH]c2ccc(OCC(=O)NCC(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)cc12
CHEMBL151420 5ht1d_human Human No 6.2 IC50 = 600 nM Bind
Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay
529 8 1 7 5.4 Cc1nc(-c2ccc(-c3ccc(C(=O)Nc4ccc(OCCF)c(N5CCN(C)CC5)c4)cc3)c(C)c2)no1
CHEMBL128 5ht1d_rat Rat Yes 7.2 IC50 = 61 nM Bind
Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL274866 5ht1d_human Human Yes 6.2 IC50 = 610 nM Bind
Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand
230 1 1 2 2.1 FC(c1cccc(c1)N1CCNCC1)(F)F
CHEMBL88783 5ht1d_human Human No 7.2 IC50 = 63.1 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
288 5 3 5 0.9 c1ccc2c(c1)CCC(CNCCNC1=NCCCN1)O2
CHEMBL2368253 5ht1d_human Human No 7.2 IC50 = 64.6 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
306 4 1 2 4.8 CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(Oc4ccccc4)cc32)C1
CHEMBL83658 5ht1d_human Human No 6.2 IC50 = 660.7 nM Bind
Binding affinity against 5-HT1D receptorBinding affinity against 5-HT1D receptor
294 2 0 3 3.4 CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1
CHEMBL83658 5ht1d_human Human No 6.2 IC50 = 660.7 nM Bind
Binding affinity for human cloned 5-hydroxytryptamine 1D receptorBinding affinity for human cloned 5-hydroxytryptamine 1D receptor
294 2 0 3 3.4 CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1
CHEMBL15808 5ht1d_rat Rat No 6.2 IC50 = 667 nM Bind
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
437 3 2 4 3.7 COc1ccc(NC(=O)N2CCc3[nH]c4ccc(F)cc4c3C2)cc1N1CCN(C)CC1
CHEMBL2368256 5ht1d_human Human No 8.2 IC50 = 7.1 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
299 4 3 3 2.3 CN[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1
CHEMBL159332 5ht1d_human Human Yes 8.1 IC50 = 7.2 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
321 5 2 3 1.9 CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C
CHEMBL113831 5ht1d_human Human No 8.1 IC50 = 7.3 nM Bind
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
424 8 3 6 3.1 CC(C)(C)CNCC1(O)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL148110 5ht1d_human Human No 8.1 IC50 = 7.6 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
471 9 3 6 3.8 C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)C(=O)Nc1ccccc1
CHEMBL356315 5ht1d_human Human No 8.1 IC50 = 7.6 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
458 9 3 6 3.9 C[C@H](O)[C@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1
CHEMBL159733 5ht1d_human Human No 8.1 IC50 = 7.7 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
428 9 1 5 3.8 CN(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(Cn4cncn4)cc23)C1
CHEMBL89427 5ht1d_human Human No 8.1 IC50 = 7.9 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
303 7 2 5 2.9 c1ccc2c(c1)CCC(CNCCCNc1nccs1)O2
CHEMBL90405 5ht1d_human Human No 8.1 IC50 = 7.9 nM Bind
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
320 6 3 5 1.4 Fc1ccc2c(c1)CCC(CNCCCNC1=NCCCN1)O2
CHEMBL151894 5ht1d_human Human No 6.2 IC50 = 700 nM Bind
Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay
533 7 1 8 4.6 COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(-c4nnc(C)o4)cc3C)cc2)cc1N1CCN(C)CC1
CHEMBL100086 5ht1d_human Human No 6.2 IC50 = 700 nM Bind
Inhibitory concentration required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HTInhibitory concentration required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT
424 5 1 6 3.4 COc1cccc(CN2CCN(C3CCC(O)(c4ccc5c(c4)OCO5)CC3)CC2)c1
CHEMBL348811 5ht1d_human Human No 6.1 IC50 = 724.4 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
271 4 2 2 2.0 CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC(N)=O)cc32)C1
CHEMBL357130 5ht1d_human Human Yes 7.1 IC50 = 76 nM Bind
Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.
294 6 1 2 3.9 CN(C)CCc1c[nH]c2ccc(OCc3ccccc3)cc12
CHEMBL142629 5ht1d_human Human Yes 7.1 IC50 = 77 nM Bind
Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.
232 5 2 2 2.8 CCN(CC)CCc1c[nH]c2ccc(O)cc12
CHEMBL142629 5ht1d_human Human Yes 7.1 IC50 = 77 nM Bind
Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells
232 5 2 2 2.8 CCN(CC)CCc1c[nH]c2ccc(O)cc12
CHEMBL18928 5ht1d_human Human No 6.1 IC50 = 776.3 nM Bind
In Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudateIn Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudate
206 3 2 3 0.6 NCCC1COc2ccc(C(N)=O)cc21
CHEMBL64003 5ht1d_human Human No 7.1 IC50 = 78 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
435 7 1 4 4.9 FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(Cc2ccccc2)CC1
CHEMBL905 5ht1d_human Human Yes 7.1 IC50 = 79.4 nM Bind
Binding activity against 5-hydroxytryptamine 3 receptor from rat cortex homogenate using [3H]-Q-ICS 205-930 as radioligand.Binding activity against 5-hydroxytryptamine 3 receptor from rat cortex homogenate using [3H]-Q-ICS 205-930 as radioligand.
269 5 1 4 1.9 CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C
CHEMBL22553 5ht1d_human Human No 8.1 IC50 = 8 nM Bind
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
536 9 6 4 4.6 NC(=O)c1ccc2[nH]cc(C3=CCC(NCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1
CHEMBL148085 5ht1d_human Human No 8.1 IC50 = 8.1 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
418 8 1 6 3.9 CN(Cc1ccoc1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL343667 5ht1d_human Human No 8.1 IC50 = 8.1 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
520 10 1 7 3.9 CN(Cc1ccc(S(C)(=O)=O)cc1)CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL147853 5ht1d_human Human No 8.1 IC50 = 8.3 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
458 10 3 6 3.3 OC[C@@H](Cc1ccccc1)NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL441296 5ht1d_human Human No 8.1 IC50 = 8.3 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
430 9 3 6 2.9 OC[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1
CHEMBL143767 5ht1d_human Human No 8.1 IC50 = 8.4 nM Bind
Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.
336 5 1 4 2.5 CN(C)CCc1c[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc12
CHEMBL161066 5ht1d_human Human No 8.1 IC50 = 8.5 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
401 8 2 6 2.8 c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)ccn1
CHEMBL63258 5ht1d_human Human No 8.1 IC50 = 8.5 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
451 8 1 5 4.6 FC(F)(Cc1c[nH]c2ccc(-n3cnnc3)cc12)CN1CCC(OCc2ccccc2)CC1
CHEMBL162930 5ht1d_human Human No 8.1 IC50 = 8.8 nM Bind
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
311 5 1 5 2.0 c1cc2[nH]cc(CCCN3CCOCC3)c2cc1-n1cnnc1
CHEMBL148095 5ht1d_human Human No 8.1 IC50 = 8.9 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
440 7 2 5 4.4 c1ccc2c(c1)CCC2NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL141706 5ht1d_human Human Yes 6.1 IC50 = 820 nM Bind
Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.
260 7 2 2 3.5 CCCN(CCC)CCc1c[nH]c2ccc(O)cc12
CHEMBL141706 5ht1d_human Human Yes 6.1 IC50 = 820 nM Bind
Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells
260 7 2 2 3.5 CCCN(CCC)CCc1c[nH]c2ccc(O)cc12
CHEMBL2110300 5ht1d_human Human No 7.1 IC50 = 89.1 nM Bind
Binding affinity against calf caudate 5-hydroxytryptamine 1D receptorBinding affinity against calf caudate 5-hydroxytryptamine 1D receptor
313 4 2 3 2.6 CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1
CHEMBL349528 5ht1d_human Human No 8.1 IC50 = 9 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
297 4 2 5 1.4 O[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1
CHEMBL159493 5ht1d_human Human No 8.0 IC50 = 9.1 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
386 7 2 5 3.7 c1ccc(NC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)cc1
CHEMBL434315 5ht1d_human Human No 8.0 IC50 = 9.3 nM Bind
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
418 8 1 6 3.9 CN(Cc1ccco1)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL2115112 5ht1d_human Human No 8.0 IC50 = 9.3 nM Bind
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
514 8 1 5 5.2 CN(Cc1ccccc1C(F)(F)F)[C@H]1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)C[C@H]1F
CHEMBL146396 5ht1d_human Human No 8.0 IC50 = 9.8 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
390 7 1 5 3.1 CC#CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1
CHEMBL15909 5ht1d_rat Rat No 6.1 IC50 = 900 nM Bind
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
505 5 3 4 4.7 CN1CCC2(CC1)COc1ccc(NC(=O)NCCN3CCC(c4c[nH]c5cc(F)ccc45)CC3)cc12
CHEMBL276928 5ht1d_rat Rat No 6.1 IC50 = 900 nM Bind
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
462 2 2 3 5.1 CN1CCC2(CC1)COc1ccc(NC(=O)N3CCC(c4c[nH]c5ccc(F)cc45)CC3)cc12
CHEMBL26427 5ht1d_human Human No 5.0 IC50 = 9300 nM Bind
Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand
258 3 0 3 2.6 CN(C)CCc1cn(C)c2ccc3c(c12)CCCO3
CHEMBL161694 5ht1d_human Human No 6.0 IC50 = 933.3 nM Bind
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
310 4 1 4 3.3 Cc1noc(Cc2ccc3[nH]cc([C@H]4C[C@H](N(C)C)C4)c3c2)n1
CHEMBL159381 5ht1d_human Human No 7.0 IC50 = 95 nM Bind
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
401 8 1 5 4.0 c1ccc(COC[C@H]2CCCN2CCc2c[nH]c3ccc(-n4cnnc4)cc23)cc1
CHEMBL1241913 5ht1d_human Human Yes 9.8 Kd = 0.2 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
468 5 1 7 3.1 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1
CHEMBL1185 5ht1d_human Human Yes 8.8 Kd = 1.5 nM Bind
Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay.Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay.
287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C
CHEMBL251541 5ht1d_human Human Yes 7.0 Kd = 112.2 nM Bind
Binding affinity to human 5HT1D receptorBinding affinity to human 5HT1D receptor
464 4 0 6 3.0 COc1cccc2c1C[C@H]1C[C@H](CN([C@@H]1C2)C)C(=O)N1CCN(CC1)c1ccc(cc1)[N+](=O)[O-]
CHEMBL1242345 5ht1d_human Human No 10.7 Ki = 0.0 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
522 7 1 7 4.1 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NCC6CC6)ncn4-5)CC3)cccc2n1
CHEMBL1242081 5ht1d_human Human No 10.4 Ki = 0.0 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
508 6 1 7 3.9 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CC6)ncn4-5)CC3)cccc2n1
CHEMBL513715 5ht1d_human Human No 10.3 Ki = 0.1 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
402 4 1 5 3.2 Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1
CHEMBL513715 5ht1d_human Human No 10.3 Ki = 0.1 nM Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
402 4 1 5 3.2 Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1
CHEMBL513715 5ht1d_human Human No 10.3 Ki = 0.1 nM Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
402 4 1 5 3.2 Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1
CHEMBL1290487 5ht1d_human Human No 10.1 Ki = 0.1 nM Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
414 4 0 4 3.8 Cc1ccc2c(N3CCN(CCc4cccc5c4CCC(=O)N5C)CC3)cccc2n1
CHEMBL469374 5ht1d_human Human No 10.1 Ki = 0.1 nM Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
434 4 0 5 3.4 Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cc(F)cc2n1
CHEMBL357478 5ht1d_human Human No 10.1 Ki = 0.1 nM Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells
609 12 5 7 3.4 NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(N4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)cc3)cc12
CHEMBL1241736 5ht1d_human Human No 10.0 Ki = 0.1 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
467 5 0 7 4.2 CC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2
CHEMBL1242167 5ht1d_human Human No 10.0 Ki = 0.1 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
522 6 1 7 4.3 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CCC6)ncn4-5)CC3)cccc2n1
CHEMBL1242904 5ht1d_human Human No 10.0 Ki = 0.1 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
425 4 0 6 4.0 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nccn4-5)CC3)cccc2n1
CHEMBL522257 5ht1d_human Human No 10.0 Ki = 0.1 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
416 4 0 5 3.3 Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1
CHEMBL1290486 5ht1d_human Human No 10.0 Ki = 0.1 nM Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
400 4 1 4 3.8 Cc1ccc2c(N3CCN(CCc4cccc5c4CCC(=O)N5)CC3)cccc2n1
CHEMBL469345 5ht1d_human Human No 10.0 Ki = 0.1 nM Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
416 4 0 5 3.3 Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1
CHEMBL522257 5ht1d_human Human No 10.0 Ki = 0.1 nM Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
416 4 0 5 3.3 Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1
CHEMBL1241913 5ht1d_human Human Yes 10.0 Ki = 0.1 nM Bind
Displacement of [3H]-5-HT from human recombinant 5HT1D receptor expressed in CHO cells after 45 mins by scintillation countingDisplacement of [3H]-5-HT from human recombinant 5HT1D receptor expressed in CHO cells after 45 mins by scintillation counting
468 5 1 7 3.1 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1
CHEMBL144030 5ht1d_human Human No 10.0 Ki = 0.1 nM Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells
454 10 4 4 4.8 NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12
CHEMBL356277 5ht1d_human Human No 10.0 Ki = 0.1 nM Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells
540 12 6 6 3.7 NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(NC(=O)COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12
CHEMBL144030 5ht1d_human Human No 10.0 Ki = 0.1 nM Bind
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting
454 10 4 4 4.8 NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12
CHEMBL1241546 5ht1d_human Human No 9.9 Ki = 0.1 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
440 4 0 7 3.7 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C)nnn4-5)CC3)cccc2n1
CHEMBL1241547 5ht1d_human Human No 9.9 Ki = 0.1 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
439 4 0 6 4.3 Cc1cn2c(n1)COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2
CHEMBL1241639 5ht1d_human Human No 9.9 Ki = 0.1 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
427 4 0 8 2.8 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nnnn4-5)CC3)cccc2n1
CHEMBL1241641 5ht1d_human Human No 9.9 Ki = 0.1 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
493 4 0 6 5.0 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nc(C(F)(F)F)cn4-5)CC3)cccc2n1
CHEMBL1241642 5ht1d_human Human No 9.9 Ki = 0.1 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
425 4 0 6 4.0 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4cncn4-5)CC3)cccc2n1
CHEMBL1241912 5ht1d_human Human No 9.9 Ki = 0.1 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
482 5 1 7 3.3 CNC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2
CHEMBL1289394 5ht1d_human Human No 9.9 Ki = 0.1 nM Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
444 4 0 5 4.3 Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@H](C)C3)cc(F)cc2n1
CHEMBL1290715 5ht1d_human Human No 9.9 Ki = 0.1 nM Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
398 4 1 4 3.7 Cc1ccc2c(N3CCN(CCc4cccc5[nH]c(=O)ccc45)CC3)cccc2n1
CHEMBL15928 5ht1d_human Human Yes 9.9 Ki = 0.1 nM Bind
Binding affinity against 5-hydroxytryptamine 1D receptor betaBinding affinity against 5-hydroxytryptamine 1D receptor beta
497 6 1 7 5.0 COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C
CHEMBL1631535 5ht1d_human Human No 9.9 Ki = 0.1 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
424 6 1 5 3.3 Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1
CHEMBL1631538 5ht1d_human Human No 9.9 Ki = 0.1 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
418 6 1 5 4.5 CCOC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
CHEMBL1241548 5ht1d_human Human No 9.8 Ki = 0.2 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
453 4 0 6 4.6 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nc(C)c(C)n4-5)CC3)cccc2n1
CHEMBL1241738 5ht1d_human Human No 9.8 Ki = 0.2 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
440 4 0 7 3.7 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nnc(C)n4-5)CC3)cccc2n1
CHEMBL1241824 5ht1d_human Human No 9.8 Ki = 0.2 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
496 5 0 7 3.7 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N(C)C)ncn4-5)CC3)cccc2n1
CHEMBL1241913 5ht1d_human Human Yes 9.8 Ki = 0.2 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
468 5 1 7 3.1 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1
CHEMBL1241998 5ht1d_human Human No 9.8 Ki = 0.2 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
510 6 1 7 4.1 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC(C)C)ncn4-5)CC3)cccc2n1
CHEMBL1242257 5ht1d_human Human No 9.8 Ki = 0.2 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
536 6 1 7 4.7 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CCCC6)ncn4-5)CC3)cccc2n1
CHEMBL1242533 5ht1d_human Human No 9.8 Ki = 0.2 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
522 5 0 7 4.2 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCCC6)ncn4-5)CC3)cccc2n1
CHEMBL1242623 5ht1d_human Human No 9.8 Ki = 0.2 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
536 5 0 7 4.6 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCCCC6)ncn4-5)CC3)cccc2n1
CHEMBL1242717 5ht1d_human Human No 9.8 Ki = 0.2 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
538 5 0 8 3.5 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCOCC6)ncn4-5)CC3)cccc2n1
CHEMBL469568 5ht1d_human Human No 9.8 Ki = 0.2 nM Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
442 5 0 5 3.8 Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C4CC4)CC3)cccc2n1
CHEMBL1631542 5ht1d_human Human No 9.8 Ki = 0.2 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
416 5 0 5 3.9 Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1
CHEMBL1631545 5ht1d_human Human No 9.8 Ki = 0.2 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
397 5 0 5 4.1 Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1
CHEMBL1632208 5ht1d_human Human No 9.8 Ki = 0.2 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
416 6 1 4 4.5 Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C(C)C)c4)CC3)cccc2n1
CHEMBL1632215 5ht1d_human Human No 9.8 Ki = 0.2 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
480 7 1 5 5.2 COc1cccc(C(=O)Nc2cccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)c2)c1
CHEMBL1632220 5ht1d_human Human No 9.8 Ki = 0.2 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
417 6 2 4 4.0 CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
CHEMBL1632221 5ht1d_human Human No 9.8 Ki = 0.2 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
431 7 2 4 4.4 CCCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
CHEMBL490417 5ht1d_human Human No 9.8 Ki = 0.2 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
402 4 1 5 3.2 Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1
CHEMBL490417 5ht1d_human Human No 9.8 Ki = 0.2 nM Bind
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
402 4 1 5 3.2 Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1
CHEMBL491839 5ht1d_human Human No 9.8 Ki = 0.2 nM Bind
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
407 4 1 5 3.1 CC1(C)Cc2cccc(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)c2O1
CHEMBL521506 5ht1d_human Human No 9.8 Ki = 0.2 nM Bind
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
436 4 1 5 3.9 Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1
CHEMBL147851 5ht1d_human Human No 9.8 Ki = 0.2 nM Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells
504 11 4 6 2.3 NCCc1c[nH]c2ccc(OCCN3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12
CHEMBL147901 5ht1d_human Human No 9.7 Ki = 0.2 nM Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells
435 11 5 5 2.2 NCCc1c[nH]c2ccc(OCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
CHEMBL1242436 5ht1d_human Human No 9.7 Ki = 0.2 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
508 5 0 7 3.8 Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCC6)ncn4-5)CC3)cccc2n1
CHEMBL472290 5ht1d_human Human No 9.7 Ki = 0.2 nM Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
430 5 0 5 3.7 CCN1C(=O)COc2c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc21
CHEMBL459282 5ht1d_human Human No 9.7 Ki = 0.2 nM Bind
Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells
457 7 0 4 5.7 Cc1ccc2c(OCCN3CCC(Cc4cccc(C5CCN(C)CC5)c4)CC3)cccc2n1
CHEMBL1631533 5ht1d_human Human No 9.7 Ki = 0.2 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
483 6 2 4 5.7 Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5F)c4)CC3)cccc2n1
CHEMBL1631540 5ht1d_human Human Yes 9.7 Ki = 0.2 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
415 5 1 4 3.4 Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1
CHEMBL1632207 5ht1d_human Human No 9.7 Ki = 0.2 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
402 6 1 4 4.3 CCC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
CHEMBL1632217 5ht1d_human Human No 9.7 Ki = 0.2 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
452 6 1 6 4.0 Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1
CHEMBL444398 5ht1d_human Human No 9.7 Ki = 0.2 nM Bind
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
390 4 2 4 3.2 Cc1cc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2[nH]1
CHEMBL485491 5ht1d_human Human No 9.7 Ki = 0.2 nM Bind
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
420 4 1 5 3.4 Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1
CHEMBL489394 5ht1d_human Human No 9.7 Ki = 0.2 nM Bind
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
420 4 1 5 3.4 Cc1ccc2c(N3CCN(CCc4cc(F)c5c(c4)NC(=O)CO5)CC3)cccc2n1
CHEMBL497980 5ht1d_human Human No 9.7 Ki = 0.2 nM Bind
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
436 4 1 5 3.9 Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)ccc(Cl)c2n1
CHEMBL490417 5ht1d_human Human No 9.7 Ki = 0.2 nM Bind
Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells
402 4 1 5 3.2 Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1
CHEMBL49826 5ht1d_human Human No 9.6 Ki = 0.3 nM Bind
Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor
270 2 1 1 4.1 CN1CCC[C@@H]1Cc1c[nH]c2ccc(C(C)(C)C)cc12
CHEMBL469567 5ht1d_human Human No 9.6 Ki = 0.3 nM Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
444 5 0 5 4.0 Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C(C)C)CC3)cccc2n1
CHEMBL190298 5ht1d_human Human No 9.6 Ki = 0.3 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
401 6 1 5 3.6 Cc1ccc2c(OCCN3CCN(Cc4cccc5[nH]cnc45)CC3)cccc2n1
CHEMBL1631532 5ht1d_human Human No 9.6 Ki = 0.3 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
404 5 1 5 4.1 COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
CHEMBL1631543 5ht1d_human Human No 9.6 Ki = 0.3 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
430 5 0 5 4.3 Cc1ccc2c(N3CCN(CCc4cccc(N5CCCOC5=O)c4)CC3)cccc2n1
CHEMBL1632206 5ht1d_human Human No 9.6 Ki = 0.3 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
388 5 1 4 3.9 CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
CHEMBL1632211 5ht1d_human Human No 9.6 Ki = 0.3 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
468 6 1 4 5.3 Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5F)c4)CC3)cccc2n1
CHEMBL1632219 5ht1d_human Human No 9.6 Ki = 0.3 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
471 6 1 6 4.9 Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5scnc5C)c4)CC3)cccc2n1
CHEMBL1632222 5ht1d_human Human No 9.6 Ki = 0.3 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
445 5 2 4 4.8 Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)NC(C)(C)C)c4)CC3)cccc2n1
CHEMBL490211 5ht1d_human Human No 9.6 Ki = 0.3 nM Bind
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
388 4 1 5 2.9 O=C1COc2ccc(CCN3CCN(c4nccc5ccccc45)CC3)cc2N1
CHEMBL496317 5ht1d_human Human No 9.6 Ki = 0.3 nM Bind
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
420 4 1 5 3.4 Cc1ccc2c(N3CCN(CCc4cc5c(cc4F)OCC(=O)N5)CC3)cccc2n1
CHEMBL523095 5ht1d_human Human No 9.6 Ki = 0.3 nM Bind
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
388 4 1 5 2.9 O=C1COc2ccc(CCN3CCN(c4cccc5cccnc45)CC3)cc2N1
CHEMBL525362 5ht1d_human Human No 9.6 Ki = 0.3 nM Bind
Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor
446 8 2 4 5.0 CCNC(=O)Nc1cccc(CC2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1
CHEMBL118563 5ht1d_human Human No 9.6 Ki = 0.3 nM Bind
Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha
500 9 3 6 1.6 CN(C)S(=O)(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1
CHEMBL1203216 5ht1d_human Human No 9.6 Ki = 0.3 nM Bind
Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha
500 9 3 6 1.6 CN(C)S(=O)(=O)Nc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1
CHEMBL357830 5ht1d_human Human No 9.6 Ki = 0.3 nM Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells
600 11 4 6 3.6 NCCc1c[nH]c2ccc(OCC(=O)N3CCC(C4CCN(C(=O)COc5ccc6[nH]cc(CCN)c6c5)CC4)CC3)cc12
CHEMBL44054 5ht1d_human Human No 9.5 Ki = 0.3 nM Bind
Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor
256 3 1 1 3.9 CC(C)c1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1
CHEMBL144397 5ht1d_human Human No 9.5 Ki = 0.3 nM Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells
506 14 6 6 1.7 NCCc1c[nH]c2ccc(OCC(=O)NCCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
CHEMBL332142 5ht1d_human Human No 9.5 Ki = 0.3 nM Bind
Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta
423 7 2 6 2.3 NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4[N+](=O)[O-])CC3)cc12
CHEMBL366322 5ht1d_human Human No 9.5 Ki = 0.3 nM Bind
Binding affinity towards human 5-hydroxytryptamine 1D receptorBinding affinity towards human 5-hydroxytryptamine 1D receptor
245 1 2 3 3.0 Cc1cc(C(C)(C)C)cc(C)c1NC1=NCCN1
CHEMBL344127 5ht1d_human Human Yes 9.5 Ki = 0.3 nM Bind
Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.
377 8 2 3 3.6 COc1ccc(CNC(=O)/C=C/c2ccc3[nH]cc(CCN(C)C)c3c2)cc1
CHEMBL503468 5ht1d_human Human No 9.5 Ki = 0.3 nM Bind
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting
770 14 4 4 10.4 O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1
CHEMBL120514 5ht1d_human Human No 9.5 Ki = 0.3 nM Bind
Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta
449 10 3 5 3.5 NCCc1c[nH]c2ccc(OCCCCCC(=O)N3CCN(c4ccc(N)cc4)CC3)cc12
CHEMBL114571 5ht1d_human Human No 9.5 Ki = 0.3 nM Bind
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor
428 4 2 2 5.4 Cc1ccc(NC(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1
CHEMBL1241640 5ht1d_human Human No 9.5 Ki = 0.3 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
497 6 0 8 4.2 CCOC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2
CHEMBL1241737 5ht1d_human Human No 9.5 Ki = 0.3 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
496 6 0 8 4.4 CO/N=C(\C)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2
CHEMBL469345 5ht1d_human Human No 9.5 Ki = 0.3 nM Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
416 4 0 5 3.3 Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1
CHEMBL469345 5ht1d_human Human No 9.5 Ki = 0.3 nM Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
416 4 0 5 3.3 Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1
CHEMBL469995 5ht1d_human Human No 9.5 Ki = 0.3 nM Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
456 6 0 5 4.0 Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5CC4CC4)CC3)cccc2n1
CHEMBL513875 5ht1d_human Human No 9.5 Ki = 0.3 nM Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
448 4 0 5 3.8 Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cc(F)cc2n1
CHEMBL1631539 5ht1d_human Human No 9.5 Ki = 0.3 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
402 5 0 4 3.9 CC(=O)N(C)c1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1
CHEMBL1631541 5ht1d_human Human No 9.5 Ki = 0.3 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
429 5 1 4 3.8 Cc1ccc2c(N3CCN(CCc4cccc(N5CCCNC5=O)c4)CC3)cccc2n1
CHEMBL1632209 5ht1d_human Human No 9.5 Ki = 0.3 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
430 5 1 4 4.9 Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)C(C)(C)C)c4)CC3)cccc2n1
CHEMBL1632210 5ht1d_human Human No 9.5 Ki = 0.3 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
450 6 1 4 5.2 Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1
CHEMBL1632212 5ht1d_human Human No 9.5 Ki = 0.3 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
468 6 1 4 5.3 Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cccc(F)c5)c4)CC3)cccc2n1
CHEMBL1632223 5ht1d_human Human No 9.5 Ki = 0.3 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
465 6 2 4 5.6 Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5)c4)CC3)cccc2n1
CHEMBL489195 5ht1d_human Human No 9.5 Ki = 0.3 nM Bind
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
403 4 1 6 2.6 Cc1ncc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1
CHEMBL495705 5ht1d_human Human No 9.5 Ki = 0.3 nM Bind
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
416 4 1 5 3.6 Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3C)cccc2n1
CHEMBL497979 5ht1d_human Human No 9.5 Ki = 0.3 nM Bind
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
420 4 1 5 3.4 Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)ccc(F)c2n1
CHEMBL522257 5ht1d_human Human No 9.5 Ki = 0.3 nM Bind
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
416 4 0 5 3.3 Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1
CHEMBL506942 5ht1d_human Human No 9.5 Ki = 0.3 nM Bind
Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor
432 7 0 5 3.7 CC(=O)N(C)c1cccc(CN2CCN(CCOc3cccc4nc(C)ccc34)CC2)c1
CHEMBL2 5ht1d_human Human Yes 9.5 Ki = 0.3 nM Bind
Binding affinity was determined for the alpha-1D adrenergic receptorBinding affinity was determined for the alpha-1D adrenergic receptor
383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1
CHEMBL121207 5ht1d_human Human No 9.5 Ki = 0.3 nM Bind
Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha
479 11 2 6 3.9 NCCc1c[nH]c2ccc(OCCCCCC(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)cc12
CHEMBL31354 5ht1d_mouse Mouse Yes 9.5 Ki = 0.3 nM Funct
Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 2)Receptor-linked G protein activation at 5-hydroxytryptamine receptor was determined by measuring the stimulation of [35S]GTP-gamma-S, binding (Experiment 2)
422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1
CHEMBL144128 5ht1d_human Human No 9.5 Ki = 0.4 nM Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells
490 12 4 6 2.7 NCCc1c[nH]c2ccc(OCCN3CCN(CCOc4ccc5[nH]cc(CCN)c5c4)CC3)cc12
CHEMBL148022 5ht1d_human Human No 9.5 Ki = 0.4 nM Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells
454 10 4 4 4.8 NCCc1c[nH]c2ccc(OCc3cccc(COc4ccc5[nH]cc(CCN)c5c4)c3)cc12
CHEMBL120514 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha
449 10 3 5 3.5 NCCc1c[nH]c2ccc(OCCCCCC(=O)N3CCN(c4ccc(N)cc4)CC3)cc12
CHEMBL113950 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor
444 4 2 2 5.8 Cc1ccc(/N=C(\S)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1
CHEMBL114780 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor
448 4 2 2 5.8 CN1CCC[C@@H]1Cc1c[nH]c2ccc(C3=CCN(C(=O)Nc4ccc(Cl)cc4)CC3)cc12
CHEMBL119927 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta
403 6 2 5 2.3 N#Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1
CHEMBL1289163 5ht1d_human Human No 9.4 Ki = 0.4 nM Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
430 4 0 5 3.9 Cc1ccc2c(N3CCN(CCc4c(F)ccc5c4ccc(=O)n5C)CC3)cccc2n1
CHEMBL470849 5ht1d_human Human No 9.4 Ki = 0.4 nM Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
416 5 1 5 3.6 Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5)CC3)cccc2n1
CHEMBL511279 5ht1d_human Human No 9.4 Ki = 0.4 nM Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
466 6 0 5 3.9 Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5CC(F)F)CC3)cccc2n1
CHEMBL511815 5ht1d_human Human No 9.4 Ki = 0.4 nM Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
430 4 0 5 3.7 Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cccc2n1
CHEMBL241463 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cells
449 6 1 5 4.3 Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cccc2n1
CHEMBL1632213 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
468 6 1 4 5.3 Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccc(F)cc5)c4)CC3)cccc2n1
CHEMBL1632218 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
471 6 1 6 4.9 Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5csc(C)n5)c4)CC3)cccc2n1
CHEMBL247428 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5HT1D receptor expressed in CHO cells
464 6 0 6 3.2 Cc1ccc2c(OCCN3CCN(Cc4cc(F)c5c(c4)N(C)C(=O)CO5)CC3)cccc2n1
CHEMBL484260 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
416 4 1 5 3.5 Cc1cc(N2CCN(CCc3ccc4c(c3)NC(=O)CO4)CC2)c2ccc(C)nc2c1
CHEMBL489393 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
430 5 0 5 3.7 CCN1C(=O)COc2ccc(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cc21
CHEMBL496520 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
420 4 1 5 3.4 Cc1ccc2c(N3CCN(CCc4ccc5c(c4F)NC(=O)CO5)CC3)cccc2n1
CHEMBL495213 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor
481 9 1 5 5.0 Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(=O)(=O)C(C)C)c4)CC3)cccc2n1
CHEMBL147677 5ht1d_human Human No 9.4 Ki = 0.4 nM Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells
464 12 6 5 2.4 NCCc1c[nH]c2ccc(OCCNC(=O)NCCOc3ccc4[nH]cc(CCN)c4c3)cc12
CHEMBL421064 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaBinding affinity for cloned human 5-hydroxytryptamine 1D receptor beta
378 6 2 4 2.4 NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4)CC3)cc12
CHEMBL300519 5ht1d_human Human Yes 9.4 Ki = 0.4 nM Bind
Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor
230 4 1 1 3.4 CC(C)c1ccc2[nH]cc(CCN(C)C)c2c1
CHEMBL352234 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determinedBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determined
408 7 2 5 2.4 COc1cccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)c1
CHEMBL762 5ht1d_human Human Yes 9.4 Ki = 0.4 nM Bind
Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligandBinding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand
260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C
CHEMBL31217 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
Binding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandBinding affinity was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand
444 8 2 5 4.0 CN1CCN(c2cccc3ccc(OCCOc4ccc5[nH]cc(CCN)c5c4)cc23)CC1
CHEMBL31217 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting
444 8 2 5 4.0 CN1CCN(c2cccc3ccc(OCCOc4ccc5[nH]cc(CCN)c5c4)cc23)CC1
CHEMBL146720 5ht1d_human Human No 9.4 Ki = 0.4 nM Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells
518 10 4 6 1.8 NCCc1c[nH]c2ccc(OCC(=O)N3CCN(C(=O)COc4ccc5[nH]cc(CCN)c5c4)CC3)cc12
CHEMBL334323 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaBinding affinity to recombinant human 5-hydroxytryptamine 1D receptor alpha
423 7 2 6 2.3 NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccc([N+](=O)[O-])cc4)CC3)cc12
CHEMBL431866 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorBinding affinity towards cloned human 5-hydroxytryptamine 1D receptor
444 5 2 3 5.1 COc1ccc(NC(=O)N2CC=C(c3ccc4[nH]cc(C[C@H]5CCCN5C)c4c3)CC2)cc1
CHEMBL423029 5ht1d_human Human No 9.4 Ki = 0.4 nM Bind
In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptorIn vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor
244 3 1 1 3.6 CN(C)CCc1c[nH]c2ccc(C(C)(C)C)cc12