Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL1310437 5ht1e_human Human Yes 5.0 IC50 = 11190 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
405 6 1 6 5.7 C1CCC(CC1)C(=O)OC(C2=CC=CC=C2)C(=O)NC3=CC=CC(=C3)C(F)(F)F
CHEMBL1310437 5ht1e_human Human Yes 5.0 IC50 = 11190 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
405 6 1 6 5.7 C1CCC(CC1)C(=O)OC(C2=CC=CC=C2)C(=O)NC3=CC=CC(=C3)C(F)(F)F
CHEMBL1404080 5ht1e_human Human Yes 4.9 IC50 = 12070 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
279 4 1 1 4.9 C1CCC(C1)C(C2=CC=CC=C2)C(=O)NC3=CC=CC=C3
CHEMBL1404080 5ht1e_human Human Yes 4.9 IC50 = 12070 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
279 4 1 1 4.9 C1CCC(C1)C(C2=CC=CC=C2)C(=O)NC3=CC=CC=C3
CHEMBL1380914 5ht1e_human Human Yes 5.9 IC50 = 1253 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
388 6 1 4 6.3 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)OC(F)F)Cl
CHEMBL1380914 5ht1e_human Human Yes 5.9 IC50 = 1253 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
388 6 1 4 6.3 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)OC(F)F)Cl
CHEMBL1424117 5ht1e_human Human Yes 4.9 IC50 = 13370 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
398 6 1 4 5.2 CC1=C(C=C(C=C1)NC(=O)C(C2=CC=CC=C2)OC(=O)C3=C(OC(=C3)C)C)Cl
CHEMBL1424117 5ht1e_human Human Yes 4.9 IC50 = 13370 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
398 6 1 4 5.2 CC1=C(C=C(C=C1)NC(=O)C(C2=CC=CC=C2)OC(=O)C3=C(OC(=C3)C)C)Cl
CHEMBL1534431 5ht1e_human Human Yes 4.9 IC50 = 13380 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
319 3 1 3 4.4 CC1=C(C=C(C=C1)NC(=O)C(C)C2=CC=C(C=C2)[N+](=O)[O-])Cl
CHEMBL1534431 5ht1e_human Human Yes 4.9 IC50 = 13380 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
319 3 1 3 4.4 CC1=C(C=C(C=C1)NC(=O)C(C)C2=CC=C(C=C2)[N+](=O)[O-])Cl
CHEMBL1548000 5ht1e_human Human Yes 4.9 IC50 = 13740 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
444 4 1 5 4.0 CC1=CC=CC=C1C(=O)N2CCN(CC2)C3=CC=C(C=C3)NC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL1548000 5ht1e_human Human Yes 4.9 IC50 = 13740 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
444 4 1 5 4.0 CC1=CC=CC=C1C(=O)N2CCN(CC2)C3=CC=C(C=C3)NC(=O)C4=CC5=C(C=C4)OCO5
CHEMBL1362304 5ht1e_human Human Yes 4.8 IC50 = 15650 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
332 5 1 3 4.2 CCC1=CC=CC=C1NC2C3=CC=CC=C3C(=O)N2CC4=CC=CO4
CHEMBL1533427 5ht1e_human Human Yes 4.8 IC50 = 15650 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
398 6 1 4 5.5 CC1=C(C=C(C=C1)NC(=O)C(C2=CC=CC=C2)OC(=O)C3=CC=C(C=C3)F)Cl
CHEMBL1362304 5ht1e_human Human Yes 4.8 IC50 = 15650 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
332 5 1 3 4.2 CCC1=CC=CC=C1NC2C3=CC=CC=C3C(=O)N2CC4=CC=CO4
CHEMBL1533427 5ht1e_human Human Yes 4.8 IC50 = 15650 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
398 6 1 4 5.5 CC1=C(C=C(C=C1)NC(=O)C(C2=CC=CC=C2)OC(=O)C3=CC=C(C=C3)F)Cl
CHEMBL1467999 5ht1e_human Human Yes 5.8 IC50 = 1755 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
429 7 1 6 4.2 CC1=CC=CC(=C1)C2=NN=C(O2)C3=CC(=CC=C3)NC(=O)CC4=CC(=C(C=C4)OC)OC
CHEMBL1467999 5ht1e_human Human Yes 5.8 IC50 = 1755 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
429 7 1 6 4.2 CC1=CC=CC(=C1)C2=NN=C(O2)C3=CC(=CC=C3)NC(=O)CC4=CC(=C(C=C4)OC)OC
CHEMBL1419954 5ht1e_human Human Yes 5.7 IC50 = 1852 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
329 4 1 1 6.2 C1CCC(C1)C(C2=CC=CC=C2)C(=O)NC3=CC4=CC=CC=C4C=C3
CHEMBL1419954 5ht1e_human Human Yes 5.7 IC50 = 1852 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
329 4 1 1 6.2 C1CCC(C1)C(C2=CC=CC=C2)C(=O)NC3=CC4=CC=CC=C4C=C3
CHEMBL2003667 5ht1e_human Human Yes 5.7 IC50 = 1963 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
375 5 1 5 3.9 C1C(C1C(=O)NN=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])C4=CC=CC=C4
CHEMBL2003667 5ht1e_human Human Yes 5.7 IC50 = 1963 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
375 5 1 5 3.9 C1C(C1C(=O)NN=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])C4=CC=CC=C4
CHEMBL1533923 5ht1e_human Human No 5.6 IC50 = 2468 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
348 7 1 2 6.2 CCCCC1CC1C(C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CS3
CHEMBL1533923 5ht1e_human Human No 5.6 IC50 = 2468 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
348 7 1 2 6.2 CCCCC1CC1C(C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CS3
CHEMBL1526126 5ht1e_human Human Yes 5.6 IC50 = 2488 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
333 3 0 5 4.0 C1C(N(N=C1C2=CC=C(C=C2)[N+](=O)[O-])C3=CC=CC=C3)C4=CC=CO4
CHEMBL1526126 5ht1e_human Human Yes 5.6 IC50 = 2488 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
333 3 0 5 4.0 C1C(N(N=C1C2=CC=C(C=C2)[N+](=O)[O-])C3=CC=CC=C3)C4=CC=CO4
CHEMBL1385499 5ht1e_human Human Yes 5.4 IC50 = 3864 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
365 5 1 3 5.2 CC1=CC(=CC=C1)CN2C(=CC(=N2)C(C)(C)C)C(=O)NC3=CC=C(C=C3)F
CHEMBL1385499 5ht1e_human Human Yes 5.4 IC50 = 3864 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
365 5 1 3 5.2 CC1=CC(=CC=C1)CN2C(=CC(=N2)C(C)(C)C)C(=O)NC3=CC=C(C=C3)F
CHEMBL22961 5ht1e_human Human No 6.4 IC50 = 392 Funct
Inhibitory activity against 5-hydroxytryptamine 1E receptor subtypeInhibitory activity against 5-hydroxytryptamine 1E receptor subtype
621 15 6 4 5.4 C1CC(=CCC1NCCCCCCCCNC2CCC(=CC2)C3=CNC4=C3C=C(C=C4)C(=O)N)C5=CNC6=C5C=C(C=C6)C(=O)N
CHEMBL1330917 5ht1e_human Human Yes 5.3 IC50 = 5284 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
414 6 1 3 6.0 CC1=C(C=C(C=C1)NC(=O)C(C2=CC=CC=C2)OC(=O)C3=CC=CC=C3Cl)Cl
CHEMBL1330917 5ht1e_human Human Yes 5.3 IC50 = 5284 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
414 6 1 3 6.0 CC1=C(C=C(C=C1)NC(=O)C(C2=CC=CC=C2)OC(=O)C3=CC=CC=C3Cl)Cl
CHEMBL1466117 5ht1e_human Human Yes 5.3 IC50 = 5463 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
402 4 2 4 4.8 CC1=CC=CC(=C1)C2(CC2C(=O)NC3=C(C=C(C=C3)[N+](=O)[O-])O)C4=CC(=CC=C4)C
CHEMBL1466117 5ht1e_human Human Yes 5.3 IC50 = 5463 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
402 4 2 4 4.8 CC1=CC=CC(=C1)C2(CC2C(=O)NC3=C(C=C(C=C3)[N+](=O)[O-])O)C4=CC(=CC=C4)C
CHEMBL128 5ht1e_human Human Yes 5.3 IC50 = 5500 Funct
Compound was evaluated for the affinity at 5-hydroxytryptamine 1E receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1E receptor
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL1503503 5ht1e_human Human Yes 5.2 IC50 = 7062 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
293 4 1 1 5.3 CC1=CC=C(C=C1)NC(=O)C(C2CCCC2)C3=CC=CC=C3
CHEMBL1503503 5ht1e_human Human Yes 5.2 IC50 = 7062 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
293 4 1 1 5.3 CC1=CC=C(C=C1)NC(=O)C(C2CCCC2)C3=CC=CC=C3
CHEMBL604664 5ht1e_human Human Yes 5.0 IC50 = 9477 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
324 3 1 3 4.3 CC1=CC=C(C=C1)NC(=O)C2(CCCC2)C3=CC=C(C=C3)[N+](=O)[O-]
CHEMBL604664 5ht1e_human Human Yes 5.0 IC50 = 9477 Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
324 3 1 3 4.3 CC1=CC=C(C=C1)NC(=O)C2(CCCC2)C3=CC=C(C=C3)[N+](=O)[O-]
CHEMBL22744 5ht1e_human Human No 7.0 IC50 = 99 Funct
Binding affinity to 5HT1E receptorBinding affinity to 5HT1E receptor
607 14 6 4 4.9 C1CC(=CCC1NCCCCCCCNC2CCC(=CC2)C3=CNC4=C3C=C(C=C4)C(=O)N)C5=CNC6=C5C=C(C=C6)C(=O)N
CHEMBL22744 5ht1e_human Human No 7.0 IC50 = 99 Funct
Binding affinity to 5HT1E receptorBinding affinity to 5HT1E receptor
607 14 6 4 4.9 C1CC(=CCC1NCCCCCCCNC2CCC(=CC2)C3=CNC4=C3C=C(C=C4)C(=O)N)C5=CNC6=C5C=C(C=C6)C(=O)N
CHEMBL22744 5ht1e_human Human No 7.0 IC50 = 99 Funct
Inhibitory activity against 5-hydroxytryptamine 1E receptor subtypeInhibitory activity against 5-hydroxytryptamine 1E receptor subtype
607 14 6 4 4.9 C1CC(=CCC1NCCCCCCCNC2CCC(=CC2)C3=CNC4=C3C=C(C=C4)C(=O)N)C5=CNC6=C5C=C(C=C6)C(=O)N
CHEMBL42 5ht1e_human Human Yes 6.0 Ki = 1000 Funct
Binding affinity to serotonin 5-HT1E receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT1E receptor (unknown origin) by PDSP assay
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL282971 5ht1e_human Human No 6.0 Ki = 1000 Funct
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1E receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1E receptor in CHO cells, using [3H]5-HT as radioligand
492 5 1 7 5.2 CC1=C(SC2=C1C=C(C=C2)Cl)S(=O)(=O)NC3=CC(=C(C=C3)OC)N4CCN5CCCC5C4
CHEMBL1258223 5ht1e_human Human No 5.0 Ki = 10000 Funct
Binding affinity to human 5-HT1E receptorBinding affinity to human 5-HT1E receptor
397 8 1 6 4.1 CCCCN1CCC(CC1)COC(=O)C2=CC(=C(C3=C2OCCO3)NC)Cl
CHEMBL1258223 5ht1e_human Human No 5.0 Ki = 10000 Funct
Binding affinity to human 5-HT1E receptorBinding affinity to human 5-HT1E receptor
397 8 1 6 4.1 CCCCN1CCC(CC1)COC(=O)C2=CC(=C(C3=C2OCCO3)NC)Cl
CHEMBL138989 5ht1e_human Human No 6.9 Ki = 140 Funct
Binding affinity towards 5-hydroxytryptamine 1E receptorBinding affinity towards 5-hydroxytryptamine 1E receptor
335 1 1 2 3.2 CC1CC(N1C(=O)C2CN(C3CC4=CNC5=CC=CC(=C45)C3=C2)C)C
CHEMBL292759 5ht1e_human Human Yes 5.8 Ki = 1584.9 Funct
Compound was tested for its binding affinity against cloned human 5-hydroxytryptamine 1E receptor in CHO cells using [3H]-5-HTCompound was tested for its binding affinity against cloned human 5-hydroxytryptamine 1E receptor in CHO cells using [3H]-5-HT
440 5 1 6 3.0 CN1CCN(CC1)C2=C(C=CC(=C2)NS(=O)(=O)C3=CC=C(C=C3)Br)OC
CHEMBL292759 5ht1e_human Human Yes 5.8 Ki = 1584.9 Funct
Compound was tested for its binding affinity against cloned human 5-hydroxytryptamine 1E receptor in CHO cells using [3H]-5-HTCompound was tested for its binding affinity against cloned human 5-hydroxytryptamine 1E receptor in CHO cells using [3H]-5-HT
440 5 1 6 3.0 CN1CCN(CC1)C2=C(C=CC(=C2)NS(=O)(=O)C3=CC=C(C=C3)Br)OC
CHEMBL29433 5ht1e_human Human No 5.8 Ki = 1584.9 Funct
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1E receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1E receptor in CHO cells, using [3H]5-HT as radioligand
492 5 1 7 5.2 CC1=C(SC2=C1C=C(C=C2)Cl)S(=O)(=O)NC3=CC(=C(C=C3)OC)N4CCN5CCCC5C4
CHEMBL7143 5ht1e_human Human Yes 5.8 Ki = 1800 Funct
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1E receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1E receptor
232 4 1 2 2.7 CC1=C(C2=C(N1)C=CC(=C2)OC)CCN(C)C
CHEMBL30713 5ht1e_human Human Yes 5.7 Ki = 1919 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1E receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]5-HT from human recombinant 5-HT1E receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis
174 2 2 1 2.0 CC(CC1=CNC2=CC=CC=C21)N
CHEMBL137781 5ht1e_human Human No 6.7 Ki = 200 Funct
Binding affinity towards 5-hydroxytryptamine 1E receptorBinding affinity towards 5-hydroxytryptamine 1E receptor
335 1 1 2 3.2 CC1CC(N1C(=O)C2CN(C3CC4=CNC5=CC=CC(=C45)C3=C2)C)C
CHEMBL497963 5ht1e_human Human No 5.6 Ki = 2511.9 Funct
Displacement of radioligand from human cloned 5HT1E receptorDisplacement of radioligand from human cloned 5HT1E receptor
454 8 1 6 4.3 CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCC(CC3)CC4=CC(=CC=C4)NS(=O)(=O)C
CHEMBL3217984 5ht1e_human Human No 5.6 Ki = 2511.9 Funct
Binding affinity to serotonin 5-HT1E receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT1E receptor (unknown origin) by PDSP assay
308 0 0 3 3.7 CN1CCC2C(C1)C3=C4N2C5=CC=CC=C5CSC4=CC=C3
CHEMBL333784 5ht1e_human Human No 5.6 Ki = 2511.9 Funct
Binding affinity towards human cloned 5-hydroxytryptamine 1E receptor in CHO cells using [3H]5-HT as radioligand.Binding affinity towards human cloned 5-hydroxytryptamine 1E receptor in CHO cells using [3H]5-HT as radioligand.
405 5 0 4 4.6 CC1CCN(CC1)CCC2CCCN2S(=O)(=O)C3=CC(=C(C=C3)Cl)Cl
CHEMBL497963 5ht1e_human Human No 5.6 Ki = 2511.9 Funct
Displacement of radioligand from human cloned 5HT1E receptorDisplacement of radioligand from human cloned 5HT1E receptor
454 8 1 6 4.3 CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCC(CC3)CC4=CC(=CC=C4)NS(=O)(=O)C
CHEMBL343755 5ht1e_human Human No 6.6 Ki = 280 Funct
Binding affinity towards 5-hydroxytryptamine 1E receptorBinding affinity towards 5-hydroxytryptamine 1E receptor
335 1 1 2 3.2 CC1CC(N1C(=O)C2CN(C3CC4=CNC5=CC=CC(=C45)C3=C2)C)C
CHEMBL3752900 5ht1e_human Human No 6.5 Ki = 354.8 Funct
Binding affinity to 5-HT 1E (unknown origin) by competition binding assayBinding affinity to 5-HT 1E (unknown origin) by competition binding assay
275 7 1 1 3.5 C=CCN(CCC1=CNC2=C1C=C(C=C2)Cl)CC=C
CHEMBL3752900 5ht1e_human Human No 6.5 Ki = 354.8 Funct
Binding affinity to 5-HT 1E (unknown origin) by competition binding assayBinding affinity to 5-HT 1E (unknown origin) by competition binding assay
275 7 1 1 3.5 C=CCN(CCC1=CNC2=C1C=C(C=C2)Cl)CC=C
CHEMBL3752576 5ht1e_human Human Yes 6.4 Ki = 380.2 Funct
Binding affinity to 5-HT 1E (unknown origin) by competition binding assayBinding affinity to 5-HT 1E (unknown origin) by competition binding assay
240 7 1 1 3.8 C=CCN(CCC1=CNC2=CC=CC=C21)CC=C
CHEMBL3752576 5ht1e_human Human Yes 6.4 Ki = 380.2 Funct
Binding affinity to 5-HT 1E (unknown origin) by competition binding assayBinding affinity to 5-HT 1E (unknown origin) by competition binding assay
240 7 1 1 3.8 C=CCN(CCC1=CNC2=CC=CC=C21)CC=C
CHEMBL3104091 5ht1e_human Human No 5.4 Ki = 4045 Funct
Displacement of [3H]5HT from 5-HT1E receptor (unknown origin)Displacement of [3H]5HT from 5-HT1E receptor (unknown origin)
288 0 0 1 3.9 CN1CCC2=C(C1)C3=C4N2C5=CC=CC=C5CCC4=CC=C3
CHEMBL2391541 5ht1e_human Human Yes 6.4 Ki = 413 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1E receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]5-HT from human recombinant 5-HT1E receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis
270 8 1 2 2.8 COC1=CC2=C(C=C1)NC=C2CCN(CC=C)CC=C
CHEMBL76237 5ht1e_human Human Yes 5.4 Ki = 4220 Funct
Compound was evaluated for its binding affinity for human 5-hydroxytryptamine 1E receptorCompound was evaluated for its binding affinity for human 5-hydroxytryptamine 1E receptor
358 6 0 4 3.5 CN(C)CCC1=CN(C2=C1C=C(C=C2)OC)S(=O)(=O)C3=CC=CC=C3
CHEMBL3754496 5ht1e_human Human No 6.3 Ki = 478.6 Funct
Binding affinity to 5-HT 1E (unknown origin) by competition binding assayBinding affinity to 5-HT 1E (unknown origin) by competition binding assay
258 7 1 2 2.9 C=CCN(CCC1=CNC2=C1C=C(C=C2)F)CC=C
CHEMBL3754496 5ht1e_human Human No 6.3 Ki = 478.6 Funct
Binding affinity to 5-HT 1E (unknown origin) by competition binding assayBinding affinity to 5-HT 1E (unknown origin) by competition binding assay
258 7 1 2 2.9 C=CCN(CCC1=CNC2=C1C=C(C=C2)F)CC=C
CHEMBL3753318 5ht1e_human Human No 6.3 Ki = 489.8 Funct
Binding affinity to 5-HT 1E (unknown origin) by competition binding assayBinding affinity to 5-HT 1E (unknown origin) by competition binding assay
254 7 1 1 3.7 CC1=CC2=C(C=C1)NC=C2CCN(CC=C)CC=C
CHEMBL3753318 5ht1e_human Human No 6.3 Ki = 489.8 Funct
Binding affinity to 5-HT 1E (unknown origin) by competition binding assayBinding affinity to 5-HT 1E (unknown origin) by competition binding assay
254 7 1 1 3.7 CC1=CC2=C(C=C1)NC=C2CCN(CC=C)CC=C
CHEMBL2391541 5ht1e_human Human Yes 6.3 Ki = 501.2 Funct
Binding affinity to 5-HT 1E (unknown origin) by competition binding assayBinding affinity to 5-HT 1E (unknown origin) by competition binding assay
270 8 1 2 2.8 COC1=CC2=C(C=C1)NC=C2CCN(CC=C)CC=C
CHEMBL2391541 5ht1e_human Human Yes 6.3 Ki = 501.2 Funct
Binding affinity to 5-HT 1E (unknown origin) by competition binding assayBinding affinity to 5-HT 1E (unknown origin) by competition binding assay
270 8 1 2 2.8 COC1=CC2=C(C=C1)NC=C2CCN(CC=C)CC=C
CHEMBL3754166 5ht1e_human Human No 6.3 Ki = 512.9 Funct
Binding affinity to 5-HT 1E (unknown origin) by competition binding assayBinding affinity to 5-HT 1E (unknown origin) by competition binding assay
319 7 1 1 3.5 C=CCN(CCC1=CNC2=C1C=C(C=C2)Br)CC=C
CHEMBL3754166 5ht1e_human Human No 6.3 Ki = 512.9 Funct
Binding affinity to 5-HT 1E (unknown origin) by competition binding assayBinding affinity to 5-HT 1E (unknown origin) by competition binding assay
319 7 1 1 3.5 C=CCN(CCC1=CNC2=C1C=C(C=C2)Br)CC=C
CHEMBL267615 5ht1e_human Human Yes 6.3 Ki = 520 Funct
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1E receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1E receptor
246 5 1 2 3.2 CCC1=C(C2=C(N1)C=CC(=C2)OC)CCN(C)C
CHEMBL432713 5ht1e_human Human Yes 8.2 Ki = 6.3 Funct
Binding affinity for 5-hydroxytryptamine 1E receptor was determinedBinding affinity for 5-hydroxytryptamine 1E receptor was determined
500 9 3 3 6.0 C1CN(CCC1C2=CNC3=C2C=C(C=C3)O)CCCCCNC(=O)C=CC4=CC(=C(C=C4)Cl)Cl
CHEMBL103479 5ht1e_human Human No 6.2 Ki = 660 Funct
In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1E receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1E receptor
352 3 2 4 2.9 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL105261 5ht1e_human Human No 6.1 Ki = 770 Funct
In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1E receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1E receptor
286 3 2 3 1.6 CCC(=O)NC1=NC2=C(C=C1)NC=C2C3CCN(CC3)C