Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL102250 5ht1f_human Human No 8.0 EC50 = 11 Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
324 3 2 4 1.9 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=COC=C4
CHEMBL105091 5ht1f_human Human No 8.0 EC50 = 11 Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
324 3 2 4 2.2 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=CO4
CHEMBL105958 5ht1f_human Human No 8.0 EC50 = 11 Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
335 3 2 4 1.7 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=NC=C4
CHEMBL3617557 5ht1f_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay
341 4 1 5 2.6 CN1CCC(CC1)C(=O)C2=NC(=CC=C2)NC(=O)C3=CC=C(C=C3)F
CHEMBL3617557 5ht1f_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay
341 4 1 5 2.6 CN1CCC(CC1)C(=O)C2=NC(=CC=C2)NC(=O)C3=CC=C(C=C3)F
CHEMBL105955 5ht1f_human Human No 7.9 EC50 = 13 Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
300 4 2 3 2.0 CCCC(=O)NC1=NC2=C(C=C1)NC=C2C3CCN(CC3)C
CHEMBL187308 5ht1f_human Human No 6.9 EC50 = 140 Funct
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
388 3 1 5 3.9 CN1CCC(CC1)C2=NOC3=C2C=C(C=C3)NC(=O)C4=C(C=C(C=C4)F)Cl
CHEMBL187308 5ht1f_human Human No 6.9 EC50 = 140 Funct
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
388 3 1 5 3.9 CN1CCC(CC1)C2=NOC3=C2C=C(C=C3)NC(=O)C4=C(C=C(C=C4)F)Cl
CHEMBL321080 5ht1f_human Human No 7.8 EC50 = 15 Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
340 3 2 4 2.8 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=CS4
CHEMBL420475 5ht1f_human Human No 7.7 EC50 = 21 Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
312 3 2 3 2.2 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4CCC4
CHEMBL105722 5ht1f_human Human No 7.6 EC50 = 25 Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
335 3 2 4 2.1 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=CC=N4
CHEMBL177238 5ht1f_human Human No 6.6 EC50 = 277 Funct
Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorConcentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor
388 3 1 5 3.8 CN1CCC(CC1)C2=COC3=C2N=C(C=C3)NC(=O)C4=C(C=C(C=C4)F)Cl
CHEMBL105261 5ht1f_human Human No 7.5 EC50 = 32 Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
286 3 2 3 1.6 CCC(=O)NC1=NC2=C(C=C1)NC=C2C3CCN(CC3)C
CHEMBL104720 5ht1f_human Human No 7.5 EC50 = 34 Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
298 3 2 3 1.6 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4CC4
CHEMBL128 5ht1f_human Human Yes 7.5 EC50 = 35 Funct
In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL431041 5ht1f_human Human Yes 7.4 EC50 = 36 Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-HT1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-HT1F receptor
272 2 2 3 1.2 CC(=O)NC1=NC2=C(C=C1)NC=C2C3CCN(CC3)C
CHEMBL186662 5ht1f_human Human No 6.3 EC50 = 470 Funct
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
371 3 1 6 3.4 CN1CCC(CC1)C2=NOC3=C2C=C(C=C3)NC(=O)C4=C(C=C(C=C4)F)F
CHEMBL186662 5ht1f_human Human No 6.3 EC50 = 470 Funct
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
371 3 1 6 3.4 CN1CCC(CC1)C2=NOC3=C2C=C(C=C3)NC(=O)C4=C(C=C(C=C4)F)F
CHEMBL187581 5ht1f_human Human No 7.3 EC50 = 50 Funct
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
390 3 2 7 3.6 CN1CCC(CC1)N2CNC3=C2C=C(C=C3)NC(=O)C4=C(C=C(C=C4F)F)F
CHEMBL187581 5ht1f_human Human No 7.3 EC50 = 50 Funct
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
390 3 2 7 3.6 CN1CCC(CC1)N2CNC3=C2C=C(C=C3)NC(=O)C4=C(C=C(C=C4F)F)F
CHEMBL3617550 5ht1f_human Human No 7.3 EC50 = 55 Funct
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay
358 4 1 5 3.1 CN1CCC(CC1)C(=O)C2=C(C(=CC=C2)NC(=O)C3=CC=C(C=C3)F)F
CHEMBL3617550 5ht1f_human Human No 7.3 EC50 = 55 Funct
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay
358 4 1 5 3.1 CN1CCC(CC1)C(=O)C2=C(C(=CC=C2)NC(=O)C3=CC=C(C=C3)F)F
CHEMBL339980 5ht1f_human Human No 8.2 EC50 = 6 Funct
In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor
339 5 2 3 3.7 CC1=C(C2=C(N1)C=CC=C2NC(=O)C3=CC=C(C=C3)F)CCN(C)C
CHEMBL186951 5ht1f_human Human No 7.2 EC50 = 63 Funct
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
389 3 2 5 4.1 CN1CCC(CC1)N2CNC3=C2C=C(C=C3)NC(=O)C4=C(C=C(C=C4)F)Cl
CHEMBL186951 5ht1f_human Human No 7.2 EC50 = 63 Funct
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
389 3 2 5 4.1 CN1CCC(CC1)N2CNC3=C2C=C(C=C3)NC(=O)C4=C(C=C(C=C4)F)Cl
CHEMBL177258 5ht1f_human Human No 7.2 EC50 = 66 Funct
Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorConcentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor
353 3 1 5 3.2 CN1CCC(CC1)C2=COC3=C2N=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL369705 5ht1f_human Human No 7.2 EC50 = 68.7 Funct
Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorConcentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor
388 3 1 5 3.8 CN1CCC(CC1)C2=COC3=C2N=C(C=C3)NC(=O)C4=C(C=CC=C4Cl)F
CHEMBL3617549 5ht1f_human Human No 7.1 EC50 = 87 Funct
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay
340 4 1 4 3.0 CN1CCC(CC1)C(=O)C2=CC(=CC=C2)NC(=O)C3=CC=C(C=C3)F
CHEMBL3617549 5ht1f_human Human No 7.1 EC50 = 87 Funct
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay
340 4 1 4 3.0 CN1CCC(CC1)C(=O)C2=CC(=CC=C2)NC(=O)C3=CC=C(C=C3)F
CHEMBL104753 5ht1f_human Human No 8.0 EC50 = 9.4 Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
340 3 2 4 2.5 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CSC=C4
CHEMBL173949 5ht1f_human Human No 7.0 EC50 = 91.7 Funct
Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorConcentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor
389 3 1 7 3.4 CN1CCC(CC1)C2=COC3=C2N=C(C=C3)NC(=O)C4=C(C=C(C=C4F)F)F
CHEMBL2110300 5ht1f_human Human No 6.4 IC50 = 363.1 Funct
Binding affinity towards human recombinant 5-hydroxytryptamine 1F receptorBinding affinity towards human recombinant 5-hydroxytryptamine 1F receptor
313 4 2 3 2.5 CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)CC4COC(=O)N4
CHEMBL292779 5ht1f_human Human No 5.4 IC50 = 3800 Funct
Compound was evaluated for the affinity at 5-hydroxytryptamine 1F receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1F receptor
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F
CHEMBL101690 5ht1f_human Human Yes 8.8 Ki = 1.6 Funct
Binding affinity at human 5HT1F receptorBinding affinity at human 5HT1F receptor
351 3 2 3 3.6 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL101690 5ht1f_human Human Yes 8.8 Ki = 1.6 Funct
Binding affinity at human 5HT1F receptorBinding affinity at human 5HT1F receptor
351 3 2 3 3.6 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL128636 5ht1f_human Human No 8.8 Ki = 1.6 Funct
Binding affinity towards human 5-hydroxytryptamine 1F receptorBinding affinity towards human 5-hydroxytryptamine 1F receptor
351 3 2 3 3.6 CN1CCC(CC1)C2=CNC3=C2C(=CC=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL101690 5ht1f_human Human Yes 8.8 Ki = 1.6 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
351 3 2 3 3.6 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL318105 5ht1f_human Human No 7.0 Ki = 100 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
230 1 2 3 1.3 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)N
CHEMBL318110 5ht1f_human Human No 7.0 Ki = 100 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
231 1 2 2 0.7 CN1CCC(CC1)C2=CNC3=C2NC(=O)C=C3
CHEMBL522708 5ht1f_human Human No 6.0 Ki = 1000 Funct
Displacement of radioligand from human cloned 5HT1F receptorDisplacement of radioligand from human cloned 5HT1F receptor
480 7 0 6 4.6 CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCC(CC3)CC4=CC(=CC=C4)N5CCCS5(=O)=O
CHEMBL522708 5ht1f_human Human No 6.0 Ki = 1000 Funct
Displacement of radioligand from human cloned 5HT1F receptorDisplacement of radioligand from human cloned 5HT1F receptor
480 7 0 6 4.6 CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCC(CC3)CC4=CC(=CC=C4)N5CCCS5(=O)=O
CHEMBL103550 5ht1f_human Human No 8.0 Ki = 11 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
352 3 2 4 2.9 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC(=CC=C4)F
CHEMBL105369 5ht1f_human Human No 8.0 Ki = 11 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
367 3 3 4 2.6 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)NC4=CC=C(C=C4)F
CHEMBL321967 5ht1f_human Human No 8.0 Ki = 11 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
326 3 2 3 2.7 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4CCCC4
CHEMBL419547 5ht1f_human Human No 8.0 Ki = 11 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
359 3 2 4 2.5 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=CC(=C4)C#N
CHEMBL3617556 5ht1f_human Human No 6.0 Ki = 1100 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
356 4 2 5 3.2 CN1CCC(CC1)C(=O)C2=C(C(=CC=C2)NC(=O)C3=CC=C(C=C3)F)O
CHEMBL3617556 5ht1f_human Human No 6.0 Ki = 1100 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
356 4 2 5 3.2 CN1CCC(CC1)C(=O)C2=C(C(=CC=C2)NC(=O)C3=CC=C(C=C3)F)O
CHEMBL186662 5ht1f_human Human No 7.9 Ki = 12 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
371 3 1 6 3.4 CN1CCC(CC1)C2=NOC3=C2C=C(C=C3)NC(=O)C4=C(C=C(C=C4)F)F
CHEMBL186662 5ht1f_human Human No 7.9 Ki = 12 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
371 3 1 6 3.4 CN1CCC(CC1)C2=NOC3=C2C=C(C=C3)NC(=O)C4=C(C=C(C=C4)F)F
CHEMBL105025 5ht1f_human Human No 7.9 Ki = 12 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
348 3 2 3 3.2 CC1=CC=CC=C1C(=O)NC2=NC3=C(C=C2)NC=C3C4CCN(CC4)C
CHEMBL420101 5ht1f_human Human No 7.9 Ki = 12 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
348 3 2 3 3.2 CC1=CC=C(C=C1)C(=O)NC2=NC3=C(C=C2)NC=C3C4CCN(CC4)C
CHEMBL609742 5ht1f_human Human No 7.9 Ki = 12.3 Funct
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
390 5 3 4 3.6 C1CC(NC1)CC2=CNC3=C2C=C(C=C3)NS(=O)(=O)C4=CC=CC=C4Cl
CHEMBL609742 5ht1f_human Human No 7.9 Ki = 12.3 Funct
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
390 5 3 4 3.6 C1CC(NC1)CC2=CNC3=C2C=C(C=C3)NS(=O)(=O)C4=CC=CC=C4Cl
CHEMBL186951 5ht1f_human Human No 7.9 Ki = 13 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
389 3 2 5 4.1 CN1CCC(CC1)N2CNC3=C2C=C(C=C3)NC(=O)C4=C(C=C(C=C4)F)Cl
CHEMBL186951 5ht1f_human Human No 7.9 Ki = 13 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
389 3 2 5 4.1 CN1CCC(CC1)N2CNC3=C2C=C(C=C3)NC(=O)C4=C(C=C(C=C4)F)Cl
CHEMBL103503 5ht1f_human Human No 7.9 Ki = 13 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
352 3 2 4 2.8 CN1CCC(CC1)C2=CNC3=CN=C(C=C23)NC(=O)C4=CC=C(C=C4)F
CHEMBL102344 5ht1f_human Human No 7.9 Ki = 13 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
328 6 2 3 3.1 CCCCCC(=O)NC1=NC2=C(C=C1)NC=C2C3CCN(CC3)C
CHEMBL105091 5ht1f_human Human No 7.9 Ki = 13 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
324 3 2 4 2.2 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=CO4
CHEMBL369391 5ht1f_human Human No 7.9 Ki = 13.5 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
341 5 1 5 3.3 CC1=C(C2=C(O1)C=CC(=N2)NC(=O)C3=CC=C(C=C3)F)CCN(C)C
CHEMBL3617551 5ht1f_human Human No 5.9 Ki = 1300 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
358 4 1 5 3.1 CN1CCC(CC1)C(=O)C2=C(C=CC(=C2)NC(=O)C3=CC=C(C=C3)F)F
CHEMBL3617551 5ht1f_human Human No 5.9 Ki = 1300 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
358 4 1 5 3.1 CN1CCC(CC1)C(=O)C2=C(C=CC(=C2)NC(=O)C3=CC=C(C=C3)F)F
CHEMBL105850 5ht1f_human Human No 7.9 Ki = 14 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
394 6 2 4 4.2 CCCCN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL319857 5ht1f_human Human No 7.9 Ki = 14 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
314 5 2 3 2.5 CCCCC(=O)NC1=NC2=C(C=C1)NC=C2C3CCN(CC3)C
CHEMBL606547 5ht1f_human Human No 7.8 Ki = 16 Funct
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
404 5 2 4 4.1 CN1CCCC1CC2=CNC3=C2C=C(C=C3)NS(=O)(=O)C4=CC=CC=C4Cl
CHEMBL321133 5ht1f_human Human No 7.8 Ki = 16 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
364 4 2 4 2.8 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC(=CC=C4)OC
CHEMBL606547 5ht1f_human Human No 7.8 Ki = 16 Funct
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
404 5 2 4 4.1 CN1CCCC1CC2=CNC3=C2C=C(C=C3)NS(=O)(=O)C4=CC=CC=C4Cl
CHEMBL187581 5ht1f_human Human No 7.8 Ki = 17 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
390 3 2 7 3.6 CN1CCC(CC1)N2CNC3=C2C=C(C=C3)NC(=O)C4=C(C=C(C=C4F)F)F
CHEMBL445651 5ht1f_human Human No 7.8 Ki = 17 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
353 3 1 5 3.3 CN1CCC(CC1)C2=NOC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL187581 5ht1f_human Human No 7.8 Ki = 17 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
390 3 2 7 3.6 CN1CCC(CC1)N2CNC3=C2C=C(C=C3)NC(=O)C4=C(C=C(C=C4F)F)F
CHEMBL445651 5ht1f_human Human No 7.8 Ki = 17 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
353 3 1 5 3.3 CN1CCC(CC1)C2=NOC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL2113386 5ht1f_human Human No 7.8 Ki = 17.8 Funct
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
495 6 3 4 3.5 C1CC(NC1)CC2=CNC3=C2C=C(C=C3)NS(=O)(=O)CC4=CC=CC=C4I
CHEMBL2113386 5ht1f_human Human No 7.8 Ki = 17.8 Funct
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
495 6 3 4 3.5 C1CC(NC1)CC2=CNC3=C2C=C(C=C3)NS(=O)(=O)CC4=CC=CC=C4I
CHEMBL104953 5ht1f_human Human No 6.8 Ki = 170 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
366 4 2 4 3.3 CCN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL3617554 5ht1f_human Human No 5.8 Ki = 1700 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
375 4 1 4 3.7 CN1CCC(CC1)C(=O)C2=C(C(=CC=C2)NC(=O)C3=CC=C(C=C3)F)Cl
CHEMBL3617554 5ht1f_human Human No 5.8 Ki = 1700 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
375 4 1 4 3.7 CN1CCC(CC1)C(=O)C2=C(C(=CC=C2)NC(=O)C3=CC=C(C=C3)F)Cl
CHEMBL105478 5ht1f_human Human No 7.8 Ki = 18 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
380 5 2 4 3.8 CCCN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL321343 5ht1f_human Human No 7.7 Ki = 19 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
379 3 2 5 2.6 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=CC=C4[N+](=O)[O-]
CHEMBL105327 5ht1f_human Human No 7.7 Ki = 19 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
308 3 2 5 0.9 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NS(=O)(=O)C
CHEMBL104384 5ht1f_human Human No 7.7 Ki = 19 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
352 3 2 4 2.9 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=CC=C4F
CHEMBL282971 5ht1f_human Human No 6.7 Ki = 199.5 Funct
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligand
492 5 1 7 5.2 CC1=C(SC2=C1C=C(C=C2)Cl)S(=O)(=O)NC3=CC(=C(C=C3)OC)N4CCN5CCCC5C4
CHEMBL425190 5ht1f_human Human Yes 5.7 Ki = 1995.3 Funct
Binding affinity for human 5-hydroxytryptamine 1F receptor Binding affinity for human 5-hydroxytryptamine 1F receptor
413 6 0 5 4.2 CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCN(CC3)CC4=CC=CC5=C4N=CC=C5
CHEMBL425190 5ht1f_human Human Yes 5.7 Ki = 1995.3 Funct
Binding affinity for human 5-hydroxytryptamine 1F receptor Binding affinity for human 5-hydroxytryptamine 1F receptor
413 6 0 5 4.2 CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCN(CC3)CC4=CC=CC5=C4N=CC=C5
CHEMBL101690 5ht1f_human Human Yes 8.7 Ki = 2.1 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
351 3 2 3 3.6 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL101690 5ht1f_human Human Yes 8.7 Ki = 2.1 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
351 3 2 3 3.6 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL101690 5ht1f_human Human Yes 8.7 Ki = 2.1 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
351 3 2 3 3.6 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL101690 5ht1f_human Human Yes 8.7 Ki = 2.1 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
351 3 2 3 3.6 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL101690 5ht1f_human Human Yes 8.7 Ki = 2.1 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
351 3 2 3 3.6 CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL361303 5ht1f_human Human Yes 8.7 Ki = 2.2 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
351 3 1 3 3.4 CN1CCC(CC1)N2C=CC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL361303 5ht1f_human Human Yes 8.7 Ki = 2.2 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
351 3 1 3 3.4 CN1CCC(CC1)N2C=CC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL173949 5ht1f_human Human No 8.6 Ki = 2.3 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
389 3 1 7 3.4 CN1CCC(CC1)C2=COC3=C2N=C(C=C3)NC(=O)C4=C(C=C(C=C4F)F)F
CHEMBL323264 5ht1f_human Human No 8.6 Ki = 2.5 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
287 2 3 3 1.0 CNC(=O)NC1=NC2=C(C=C1)NC=C2C3CCN(CC3)C
CHEMBL606556 5ht1f_human Human No 8.6 Ki = 2.7 Funct
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
404 5 2 4 4.1 CN1CCCC1CC2=CNC3=C2C=C(C=C3)NS(=O)(=O)C4=CC(=CC=C4)Cl
CHEMBL606556 5ht1f_human Human No 8.6 Ki = 2.7 Funct
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
404 5 2 4 4.1 CN1CCCC1CC2=CNC3=C2C=C(C=C3)NS(=O)(=O)C4=CC(=CC=C4)Cl
CHEMBL369705 5ht1f_human Human No 8.5 Ki = 2.9 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
388 3 1 5 3.8 CN1CCC(CC1)C2=COC3=C2N=C(C=C3)NC(=O)C4=C(C=CC=C4Cl)F
CHEMBL101686 5ht1f_human Human No 7.7 Ki = 20 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
357 8 2 3 4.1 CCCCCCCC(=O)NC1=NC2=C(C=C1)NC=C2C3CCN(CC3)C
CHEMBL418806 5ht1f_human Human No 7.7 Ki = 20 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
340 3 2 3 3.2 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4CCCCC4
CHEMBL321562 5ht1f_human Human No 7.7 Ki = 20 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
364 4 2 4 2.8 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=CC=C4OC
CHEMBL317535 5ht1f_human Human No 5.7 Ki = 2000 Funct
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
260 6 1 3 2.9 CCOC(=O)C1=C(C2=CC=CC=C2N1)CCN(C)C
CHEMBL103058 5ht1f_human Human No 7.7 Ki = 21 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
284 3 2 3 1.2 CCN1CCC(=CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C
CHEMBL104026 5ht1f_human Human No 6.7 Ki = 210 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
272 2 2 3 1.1 CC(=O)NC1=NC=C2C(=C1)C(=CN2)C3CCN(CC3)C
CHEMBL104158 5ht1f_human Human No 6.7 Ki = 220 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
273 2 2 4 0.5 CC(=O)NC1=NC=C2C(=N1)C(=CN2)C3CCN(CC3)C
CHEMBL104374 5ht1f_human Human No 7.6 Ki = 23 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
245 2 1 3 1.9 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)OC
CHEMBL3617560 5ht1f_human Human No 5.6 Ki = 2400 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
341 4 1 5 2.3 CN1CCC(CC1)C(=O)C2=CC(=NC=C2)NC(=O)C3=CC=C(C=C3)F
CHEMBL3617560 5ht1f_human Human No 5.6 Ki = 2400 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
341 4 1 5 2.3 CN1CCC(CC1)C(=O)C2=CC(=NC=C2)NC(=O)C3=CC=C(C=C3)F
CHEMBL316979 5ht1f_human Human No 7.6 Ki = 25 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
364 4 2 4 2.9 CCN1CCC(=CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL128 5ht1f_human Human Yes 7.6 Ki = 25.7 Funct
Binding affinity towards human 5-hydroxytryptamine 1F receptor was determinedBinding affinity towards human 5-hydroxytryptamine 1F receptor was determined
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL76237 5ht1f_human Human Yes 5.6 Ki = 2500 Funct
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
358 6 0 4 3.5 CN(C)CCC1=CN(C2=C1C=C(C=C2)OC)S(=O)(=O)C3=CC=CC=C3
CHEMBL104968 5ht1f_human Human No 7.6 Ki = 27 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
388 4 2 6 2.6 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NS(=O)(=O)C4=CC=C(C=C4)F
CHEMBL263700 5ht1f_human Human No 7.5 Ki = 29 Funct
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO using [3H]5-HT radioligand
308 4 1 3 3.5 CN(C)CCC1=CN(C2=C1C=C(C=C2)O)C(=O)C3=CC=CC=C3
CHEMBL177238 5ht1f_human Human No 8.5 Ki = 3 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
388 3 1 5 3.8 CN1CCC(CC1)C2=COC3=C2N=C(C=C3)NC(=O)C4=C(C=C(C=C4)F)Cl
CHEMBL177258 5ht1f_human Human No 8.5 Ki = 3.1 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
353 3 1 5 3.2 CN1CCC(CC1)C2=COC3=C2N=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL432713 5ht1f_human Human Yes 8.5 Ki = 3.2 Funct
Binding affinity for 5-hydroxytryptamine 1F receptor was determinedBinding affinity for 5-hydroxytryptamine 1F receptor was determined
500 9 3 3 6.0 C1CN(CCC1C2=CNC3=C2C=C(C=C3)O)CCCCCNC(=O)C=CC4=CC(=C(C=C4)Cl)Cl
CHEMBL187308 5ht1f_human Human No 8.4 Ki = 3.6 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
388 3 1 5 3.9 CN1CCC(CC1)C2=NOC3=C2C=C(C=C3)NC(=O)C4=C(C=C(C=C4)F)Cl
CHEMBL187308 5ht1f_human Human No 8.4 Ki = 3.6 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
388 3 1 5 3.9 CN1CCC(CC1)C2=NOC3=C2C=C(C=C3)NC(=O)C4=C(C=C(C=C4)F)Cl
CHEMBL421287 5ht1f_human Human No 8.4 Ki = 3.8 Funct
Binding affinity towards human 5-hydroxytryptamine 1F receptorBinding affinity towards human 5-hydroxytryptamine 1F receptor
325 5 2 3 3.3 CN(C)CCC1=CNC2=C1C(=CC=C2)NC(=O)C3=CC=C(C=C3)F
CHEMBL102292 5ht1f_human Human No 8.4 Ki = 3.8 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
301 3 3 3 1.4 CCNC(=O)NC1=NC2=C(C=C1)NC=C2C3CCN(CC3)C
CHEMBL184597 5ht1f_human Human No 8.4 Ki = 3.9 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
352 3 2 4 3.1 CN1CCC(CC1)C2=C3C=C(C=CC3=NN2)NC(=O)C4=CC=C(C=C4)F
CHEMBL92139 5ht1f_human Human No 8.4 Ki = 3.9 Funct
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
328 5 0 3 3.5 CN(C)CCC1=C2C=CN(C2=CC=C1)S(=O)(=O)C3=CC=CC=C3
CHEMBL184597 5ht1f_human Human No 8.4 Ki = 3.9 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
352 3 2 4 3.1 CN1CCC(CC1)C2=C3C=C(C=CC3=NN2)NC(=O)C4=CC=C(C=C4)F
CHEMBL105240 5ht1f_human Human No 7.5 Ki = 30 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
380 4 2 4 3.7 CC(C)N1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL292759 5ht1f_human Human Yes 6.5 Ki = 316.2 Funct
Compound was tested for its binding affinity against 5-hydroxytryptamine 1F receptor in human cloned receptors in CHO cells using [3H]5-HTCompound was tested for its binding affinity against 5-hydroxytryptamine 1F receptor in human cloned receptors in CHO cells using [3H]5-HT
440 5 1 6 3.0 CN1CCN(CC1)C2=C(C=CC(=C2)NS(=O)(=O)C3=CC=C(C=C3)Br)OC
CHEMBL292759 5ht1f_human Human Yes 6.5 Ki = 316.2 Funct
Compound was tested for its binding affinity against 5-hydroxytryptamine 1F receptor in human cloned receptors in CHO cells using [3H]5-HTCompound was tested for its binding affinity against 5-hydroxytryptamine 1F receptor in human cloned receptors in CHO cells using [3H]5-HT
440 5 1 6 3.0 CN1CCN(CC1)C2=C(C=CC(=C2)NS(=O)(=O)C3=CC=C(C=C3)Br)OC
CHEMBL29433 5ht1f_human Human No 6.5 Ki = 316.2 Funct
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligand
492 5 1 7 5.2 CC1=C(SC2=C1C=C(C=C2)Cl)S(=O)(=O)NC3=CC(=C(C=C3)OC)N4CCN5CCCC5C4
CHEMBL3617559 5ht1f_human Human No 5.5 Ki = 3200 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
341 4 1 5 2.0 CN1CCC(CC1)C(=O)C2=CC(=CN=C2)NC(=O)C3=CC=C(C=C3)F
CHEMBL3617559 5ht1f_human Human No 5.5 Ki = 3200 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
341 4 1 5 2.0 CN1CCC(CC1)C(=O)C2=CC(=CN=C2)NC(=O)C3=CC=C(C=C3)F
CHEMBL40650 5ht1f_rat Rat Yes 5.5 Ki = 3380 Funct
Binding affinity against 5-hydroxytryptamine 1 receptor using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1 receptor using [3H]5-HT as radioligand
449 4 1 6 3.2 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=C(C6=C(S5)C=CC=N6)NC4=O
CHEMBL104946 5ht1f_human Human No 7.5 Ki = 35 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
272 3 3 3 1.2 CCC(=O)NC1=NC2=C(C=C1)NC=C2C3CCNCC3
CHEMBL365405 5ht1f_human Human Yes 8.4 Ki = 4.1 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
352 3 1 4 3.0 CN1CCC(CC1)N2C3=C(C=CC(=C3)NC(=O)C4=CC=C(C=C4)F)C=N2
CHEMBL365405 5ht1f_human Human Yes 8.4 Ki = 4.1 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
352 3 1 4 3.0 CN1CCC(CC1)N2C3=C(C=CC(=C3)NC(=O)C4=CC=C(C=C4)F)C=N2
CHEMBL104496 5ht1f_human Human No 8.4 Ki = 4.1 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
403 3 2 3 4.1 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=C(C=C(C=C4)Cl)Cl
CHEMBL102250 5ht1f_human Human No 8.3 Ki = 4.6 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
324 3 2 4 1.9 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=COC=C4
CHEMBL105556 5ht1f_human Human No 8.3 Ki = 4.7 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
309 3 1 5 1.5 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)OS(=O)(=O)C
CHEMBL361061 5ht1f_human Human No 8.3 Ki = 4.8 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
353 3 1 4 3.6 CN1CCC(CC1)N2CCC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL361061 5ht1f_human Human No 8.3 Ki = 4.8 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
353 3 1 4 3.6 CN1CCC(CC1)N2CCC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL3617552 5ht1f_human Human No 7.4 Ki = 41 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
358 4 1 5 3.1 CN1CCC(CC1)C(=O)C2=CC(=CC(=C2)F)NC(=O)C3=CC=C(C=C3)F
CHEMBL3617552 5ht1f_human Human No 7.4 Ki = 41 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
358 4 1 5 3.1 CN1CCC(CC1)C(=O)C2=CC(=CC(=C2)F)NC(=O)C3=CC=C(C=C3)F
CHEMBL105118 5ht1f_human Human No 7.4 Ki = 42 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
379 3 2 5 2.6 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC(=CC=C4)[N+](=O)[O-]
CHEMBL322018 5ht1f_human Human No 7.4 Ki = 45 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
258 2 3 3 0.7 CC(=O)NC1=NC2=C(C=C1)NC=C2C3CCNCC3
CHEMBL125745 5ht1f_human Human No 7.3 Ki = 47 Funct
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
300 4 1 3 2.5 C1=CC=C(C=C1)S(=O)(=O)N2C=CC3=C(C=CC=C32)CCN
CHEMBL431041 5ht1f_human Human Yes 8.3 Ki = 5 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
272 2 2 3 1.2 CC(=O)NC1=NC2=C(C=C1)NC=C2C3CCN(CC3)C
CHEMBL3617549 5ht1f_human Human No 8.3 Ki = 5.1 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
340 4 1 4 3.0 CN1CCC(CC1)C(=O)C2=CC(=CC=C2)NC(=O)C3=CC=C(C=C3)F
CHEMBL3617549 5ht1f_human Human No 8.3 Ki = 5.1 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
340 4 1 4 3.0 CN1CCC(CC1)C(=O)C2=CC(=CC=C2)NC(=O)C3=CC=C(C=C3)F
CHEMBL105261 5ht1f_human Human No 8.3 Ki = 5.5 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
286 3 2 3 1.6 CCC(=O)NC1=NC2=C(C=C1)NC=C2C3CCN(CC3)C
CHEMBL449406 5ht1f_human Human No 8.2 Ki = 5.8 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
348 3 2 3 3.2 CC1=CC=CC(=C1)C(=O)NC2=NC3=C(C=C2)NC=C3C4CCN(CC4)C
CHEMBL497963 5ht1f_human Human No 6.3 Ki = 501.2 Funct
Displacement of radioligand from human cloned 5HT1F receptorDisplacement of radioligand from human cloned 5HT1F receptor
454 8 1 6 4.3 CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCC(CC3)CC4=CC(=CC=C4)NS(=O)(=O)C
CHEMBL497963 5ht1f_human Human No 6.3 Ki = 501.2 Funct
Displacement of radioligand from human cloned 5HT1F receptorDisplacement of radioligand from human cloned 5HT1F receptor
454 8 1 6 4.3 CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCC(CC3)CC4=CC(=CC=C4)NS(=O)(=O)C
CHEMBL184994 5ht1f_human Human No 6.3 Ki = 520 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
369 3 1 5 3.3 CN1CCC(CC1)N2CCOC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL184994 5ht1f_human Human No 6.3 Ki = 520 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
369 3 1 5 3.3 CN1CCC(CC1)N2CCOC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL3617553 5ht1f_human Human No 6.3 Ki = 530 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
358 4 1 5 3.1 CN1CCC(CC1)C(=O)C2=CC(=C(C=C2)F)NC(=O)C3=CC=C(C=C3)F
CHEMBL3617553 5ht1f_human Human No 6.3 Ki = 530 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
358 4 1 5 3.1 CN1CCC(CC1)C(=O)C2=CC(=C(C=C2)F)NC(=O)C3=CC=C(C=C3)F
CHEMBL126340 5ht1f_human Human No 6.2 Ki = 570 Funct
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
433 7 0 4 5.2 CN(C)CCC1=C2C=C(N(C2=CC=C1)S(=O)(=O)C3=CC=CC=C3)C(=O)C4=CC=CC=C4
CHEMBL105722 5ht1f_human Human No 8.2 Ki = 6.3 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
335 3 2 4 2.1 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=CC=N4
CHEMBL105955 5ht1f_human Human No 8.2 Ki = 6.9 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
300 4 2 3 2.0 CCCC(=O)NC1=NC2=C(C=C1)NC=C2C3CCN(CC3)C
CHEMBL3616488 5ht1f_human Human No 6.2 Ki = 610 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
370 5 1 5 3.0 CN1CCC(CC1)C(=O)C2=C(C(=CC=C2)NC(=O)C3=CC=C(C=C3)F)OC
CHEMBL3616488 5ht1f_human Human No 6.2 Ki = 610 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
370 5 1 5 3.0 CN1CCC(CC1)C(=O)C2=C(C(=CC=C2)NC(=O)C3=CC=C(C=C3)F)OC
CHEMBL321578 5ht1f_human Human No 7.2 Ki = 62 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
314 3 2 3 2.6 CC(C)(C)C(=O)NC1=NC2=C(C=C1)NC=C2C3CCN(CC3)C
CHEMBL320198 5ht1f_human Human No 7.2 Ki = 67 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
353 3 2 5 2.3 CN1CCC(CC1)C2=CNC3=CN=C(N=C23)NC(=O)C4=CC=C(C=C4)F
CHEMBL321080 5ht1f_human Human No 8.2 Ki = 7.1 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
340 3 2 4 2.8 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=CS4
CHEMBL104484 5ht1f_human Human No 8.1 Ki = 7.2 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
359 3 2 4 2.5 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=C(C=C4)C#N
CHEMBL105743 5ht1f_human Human No 8.1 Ki = 7.3 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
334 3 2 3 2.8 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=CC=C4
CHEMBL104753 5ht1f_human Human No 8.1 Ki = 7.4 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
340 3 2 4 2.5 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CSC=C4
CHEMBL319920 5ht1f_human Human No 8.1 Ki = 7.5 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
389 4 1 6 3.2 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)OS(=O)(=O)C4=CC=C(C=C4)F
CHEMBL103479 5ht1f_human Human No 8.1 Ki = 7.6 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
352 3 2 4 2.9 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL103479 5ht1f_human Human No 8.1 Ki = 7.6 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
352 3 2 4 2.9 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL104692 5ht1f_human Human No 8.1 Ki = 7.7 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
379 3 2 5 2.6 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=C(C=C4)[N+](=O)[O-]
CHEMBL495075 5ht1f_human Human Yes 5.1 Ki = 7200 Funct
Binding affinity to 5HT1F receptorBinding affinity to 5HT1F receptor
527 6 2 4 5.0 C1CNCCC1OC2=C(C=C(C=C2)CN3CCC(C3)NC(=O)C4=CC(=C(C=C4)Cl)Cl)Br
CHEMBL495075 5ht1f_human Human Yes 5.1 Ki = 7200 Funct
Binding affinity to 5HT1F receptorBinding affinity to 5HT1F receptor
527 6 2 4 5.0 C1CNCCC1OC2=C(C=C(C=C2)CN3CCC(C3)NC(=O)C4=CC(=C(C=C4)Cl)Cl)Br
CHEMBL102182 5ht1f_human Human No 7.1 Ki = 75 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
443 6 2 4 4.9 C1CN(CCC1C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=C(C=C4)F)CCC5=CC=CC=C5
CHEMBL93868 5ht1f_human Human No 6.1 Ki = 770 Funct
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
328 5 0 3 3.5 CN(C)CCC1=CN(C2=CC=CC=C21)S(=O)(=O)C3=CC=CC=C3
CHEMBL339980 5ht1f_human Human No 8.1 Ki = 8.2 Funct
Binding affinity towards human 5-hydroxytryptamine 1F receptor using [3H]-5-HT radioligandBinding affinity towards human 5-hydroxytryptamine 1F receptor using [3H]-5-HT radioligand
339 5 2 3 3.7 CC1=C(C2=C(N1)C=CC=C2NC(=O)C3=CC=C(C=C3)F)CCN(C)C
CHEMBL178066 5ht1f_human Human Yes 8.1 Ki = 8.2 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
339 5 2 3 3.7 CC1=C(C2=C(N1)C=CC(=C2)NC(=O)C3=CC=C(C=C3)F)CCN(C)C
CHEMBL3617550 5ht1f_human Human No 8.1 Ki = 8.3 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
358 4 1 5 3.1 CN1CCC(CC1)C(=O)C2=C(C(=CC=C2)NC(=O)C3=CC=C(C=C3)F)F
CHEMBL3617550 5ht1f_human Human No 8.1 Ki = 8.3 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
358 4 1 5 3.1 CN1CCC(CC1)C(=O)C2=C(C(=CC=C2)NC(=O)C3=CC=C(C=C3)F)F
CHEMBL105958 5ht1f_human Human No 8.1 Ki = 8.4 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
335 3 2 4 1.7 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=NC=C4
CHEMBL187952 5ht1f_human Human No 8.1 Ki = 8.6 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
353 3 2 4 3.5 CN1CCC(CC1)C2CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL187952 5ht1f_human Human No 8.1 Ki = 8.6 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
353 3 2 4 3.5 CN1CCC(CC1)C2CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL420475 5ht1f_human Human No 8.1 Ki = 8.7 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
312 3 2 3 2.2 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4CCC4
CHEMBL3617555 5ht1f_human Human No 6.1 Ki = 870 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
354 4 1 4 3.4 CC1=C(C=CC=C1NC(=O)C2=CC=C(C=C2)F)C(=O)C3CCN(CC3)C
CHEMBL3617555 5ht1f_human Human No 6.1 Ki = 870 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
354 4 1 4 3.4 CC1=C(C=CC=C1NC(=O)C2=CC=C(C=C2)F)C(=O)C3CCN(CC3)C
CHEMBL187952 5ht1f_human Human No 8.1 Ki = 9 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
353 3 2 4 3.5 CN1CCC(CC1)C2CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL3617557 5ht1f_human Human No 8.0 Ki = 9.5 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
341 4 1 5 2.6 CN1CCC(CC1)C(=O)C2=NC(=CC=C2)NC(=O)C3=CC=C(C=C3)F
CHEMBL3617557 5ht1f_human Human No 8.0 Ki = 9.5 Funct
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
341 4 1 5 2.6 CN1CCC(CC1)C(=O)C2=NC(=CC=C2)NC(=O)C3=CC=C(C=C3)F
CHEMBL102335 5ht1f_human Human No 8.0 Ki = 9.5 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
338 3 3 4 2.4 C1CNCCC1C2=CNC3=C2N=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL187952 5ht1f_human Human No 8.0 Ki = 9.6 Funct
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
353 3 2 4 3.5 CN1CCC(CC1)C2CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
CHEMBL103424 5ht1f_human Human Yes 8.0 Ki = 9.7 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
271 2 2 2 1.8 CC(=O)NC1=CC2=C(C=C1)NC=C2C3CCN(CC3)C
CHEMBL104720 5ht1f_human Human No 8.0 Ki = 9.8 Funct
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
298 3 2 3 1.6 CN1CCC(CC1)C2=CNC3=C2N=C(C=C3)NC(=O)C4CC4