Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
367 3822 12 None -1 8 Human 9.5 pAC50 = 9.5 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 392 4 1 6 2.3 O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3 10.1038/s41467-023-40064-9
5487427 3822 12 None -1 8 Human 9.5 pAC50 = 9.5 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 392 4 1 6 2.3 O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3 10.1038/s41467-023-40064-9
8592 3822 12 None -1 8 Human 9.5 pAC50 = 9.5 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 392 4 1 6 2.3 O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3 10.1038/s41467-023-40064-9
CHEMBL1900528 3822 12 None -1 8 Human 9.5 pAC50 = 9.5 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 392 4 1 6 2.3 O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3 10.1038/s41467-023-40064-9
CHEMBL3305968 3822 12 None -1 8 Human 9.5 pAC50 = 9.5 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 392 4 1 6 2.3 O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3 10.1038/s41467-023-40064-9
CHEMBL4650755 3822 12 None -1 8 Human 9.5 pAC50 = 9.5 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 392 4 1 6 2.3 O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3 10.1038/s41467-023-40064-9
DB01409 3822 12 None -1 8 Human 9.5 pAC50 = 9.5 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 392 4 1 6 2.3 O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3 10.1038/s41467-023-40064-9
CHEMBL5292015 194535 0 None 1 5 Human 9.3 pAC50 = 9.3 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 398 6 1 3 3.6 C[N@+]1(CCF)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2 10.1038/s41467-023-40064-9
367 3822 12 None -1 8 Human 9.1 pAC50 = 9.1 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 4 1 6 2.3 O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3 10.1038/s41467-023-40064-9
5487427 3822 12 None -1 8 Human 9.1 pAC50 = 9.1 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 4 1 6 2.3 O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3 10.1038/s41467-023-40064-9
8592 3822 12 None -1 8 Human 9.1 pAC50 = 9.1 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 4 1 6 2.3 O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3 10.1038/s41467-023-40064-9
CHEMBL1900528 3822 12 None -1 8 Human 9.1 pAC50 = 9.1 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 4 1 6 2.3 O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3 10.1038/s41467-023-40064-9
CHEMBL3305968 3822 12 None -1 8 Human 9.1 pAC50 = 9.1 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 4 1 6 2.3 O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3 10.1038/s41467-023-40064-9
CHEMBL4650755 3822 12 None -1 8 Human 9.1 pAC50 = 9.1 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 4 1 6 2.3 O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3 10.1038/s41467-023-40064-9
DB01409 3822 12 None -1 8 Human 9.1 pAC50 = 9.1 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 4 1 6 2.3 O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3 10.1038/s41467-023-40064-9
1201549 596 24 None -1 26 Human 9.0 pAC50 = 9.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
333 596 24 None -1 26 Human 9.0 pAC50 = 9.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
7601 596 24 None -1 26 Human 9.0 pAC50 = 9.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1201203 596 24 None -1 26 Human 9.0 pAC50 = 9.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL438151 596 24 None -1 26 Human 9.0 pAC50 = 9.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
DB00245 596 24 None -1 26 Human 9.0 pAC50 = 9.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
3000322 3560 38 None 1 3 Human 8.8 pAC50 = 8.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 303 4 1 5 0.9 OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C 10.1038/s41467-023-40064-9
330 3560 38 None 1 3 Human 8.8 pAC50 = 8.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 303 4 1 5 0.9 OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C 10.1038/s41467-023-40064-9
CHEMBL569713 3560 38 None 1 3 Human 8.8 pAC50 = 8.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 303 4 1 5 0.9 OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C 10.1038/s41467-023-40064-9
DB00747 3560 38 None 1 3 Human 8.8 pAC50 = 8.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 303 4 1 5 0.9 OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C 10.1038/s41467-023-40064-9
3000322 3560 38 None 1 3 Human 8.8 pAC50 = 8.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 303 4 1 5 0.9 OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C 10.1038/s41467-023-40064-9
330 3560 38 None 1 3 Human 8.8 pAC50 = 8.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 303 4 1 5 0.9 OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C 10.1038/s41467-023-40064-9
CHEMBL569713 3560 38 None 1 3 Human 8.8 pAC50 = 8.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 303 4 1 5 0.9 OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C 10.1038/s41467-023-40064-9
DB00747 3560 38 None 1 3 Human 8.8 pAC50 = 8.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 303 4 1 5 0.9 OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C 10.1038/s41467-023-40064-9
4167 14498 43 None -2 10 Human 8.0 pAC50 = 8.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 309 2 0 2 5.0 CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1 10.1038/s41467-023-40064-9
CHEMBL1201342 14498 43 None -2 10 Human 8.0 pAC50 = 8.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 309 2 0 2 5.0 CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1 10.1038/s41467-023-40064-9
5022 1649 76 None -229 9 Human 5.0 pAC50 = 5 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 390 4 1 4 3.2 O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2 10.1038/s41467-023-40064-9
6918248 1649 76 None -229 9 Human 5.0 pAC50 = 5 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 390 4 1 4 3.2 O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2 10.1038/s41467-023-40064-9
8182 1649 76 None -229 9 Human 5.0 pAC50 = 5 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 390 4 1 4 3.2 O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2 10.1038/s41467-023-40064-9
CHEMBL231068 1649 76 None -229 9 Human 5.0 pAC50 = 5 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 390 4 1 4 3.2 O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2 10.1038/s41467-023-40064-9
DB04908 1649 76 None -229 9 Human 5.0 pAC50 = 5 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 390 4 1 4 3.2 O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2 10.1038/s41467-023-40064-9
5330286 67569 104 None -1 8 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 447 5 2 9 3.0 CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O 10.1038/s41467-023-40064-9
CHEMBL189963 67569 104 None -1 8 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 447 5 2 9 3.0 CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O 10.1038/s41467-023-40064-9
37907 35396 88 None 1 3 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 292 4 0 4 3.7 CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n1ccnc1 10.1038/s41467-023-40064-9
CHEMBL1437764 35396 88 None 1 3 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 292 4 0 4 3.7 CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n1ccnc1 10.1038/s41467-023-40064-9
115368 3054 47 None -3388 9 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 426 6 0 6 3.4 O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2 10.1038/s41467-023-40064-9
2112 3054 47 None -3388 9 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 426 6 0 6 3.4 O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2 10.1038/s41467-023-40064-9
7556 3054 47 None -3388 9 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 426 6 0 6 3.4 O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2 10.1038/s41467-023-40064-9
CHEMBL1472975 3054 47 None -3388 9 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 426 6 0 6 3.4 O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2 10.1038/s41467-023-40064-9
DB08922 3054 47 None -3388 9 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 426 6 0 6 3.4 O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2 10.1038/s41467-023-40064-9
98941 46948 17 None -51 11 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 457 7 0 4 6.3 COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
CHEMBL154126 46948 17 None -51 11 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 457 7 0 4 6.3 COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
28061 36754 107 None - 1 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 219 4 1 5 0.7 Cc1ncc([N+](=O)[O-])n1CC(O)CCl 10.1038/s41467-023-40064-9
CHEMBL1449676 36754 107 None - 1 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 219 4 1 5 0.7 Cc1ncc([N+](=O)[O-])n1CC(O)CCl 10.1038/s41467-023-40064-9
456199 85558 76 None - 1 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 359 5 0 7 2.7 O=[N+]([O-])c1cn2c(n1)OC[C@@H](OCc1ccc(OC(F)(F)F)cc1)C2 10.1038/s41467-023-40064-9
CHEMBL227875 85558 76 None - 1 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 359 5 0 7 2.7 O=[N+]([O-])c1cn2c(n1)OC[C@@H](OCc1ccc(OC(F)(F)F)cc1)C2 10.1038/s41467-023-40064-9
54260 186837 46 None 1 3 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 317 6 0 2 4.7 CCC(C)(C)c1ccc(CC(C)CN2C[C@@H](C)O[C@@H](C)C2)cc1 10.1038/s41467-023-40064-9
CHEMBL489411 186837 46 None 1 3 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 317 6 0 2 4.7 CCC(C)(C)c1ccc(CC(C)CN2C[C@@H](C)O[C@@H](C)C2)cc1 10.1038/s41467-023-40064-9
12488 1655 56 None -144 28 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F 10.1038/s41467-023-40064-9
941361 1655 56 None -144 28 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F 10.1038/s41467-023-40064-9
CHEMBL30008 1655 56 None -144 28 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F 10.1038/s41467-023-40064-9
DB04841 1655 56 None -144 28 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F 10.1038/s41467-023-40064-9
54454 5256 88 None -4 14 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 418 6 1 5 4.6 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
CHEMBL1064 5256 88 None -4 14 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 418 6 1 5 4.6 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
5523 3849 25 None -7 3 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 4 1 3 2.6 COc1cccc(c1)C1(O)CCCCC1CN(C)C 10.1038/s41467-023-40064-9
8286 3849 25 None -7 3 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 4 1 3 2.6 COc1cccc(c1)C1(O)CCCCC1CN(C)C 10.1038/s41467-023-40064-9
CHEMBL1237044 3849 25 None -7 3 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 4 1 3 2.6 COc1cccc(c1)C1(O)CCCCC1CN(C)C 10.1038/s41467-023-40064-9
DB00193 3849 25 None -7 3 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 4 1 3 2.6 COc1cccc(c1)C1(O)CCCCC1CN(C)C 10.1038/s41467-023-40064-9
11511120 78392 86 None -1 5 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 469 7 2 6 5.2 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN1CCCCC1 10.1038/s41467-023-40064-9
CHEMBL2110732 78392 86 None -1 5 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 469 7 2 6 5.2 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN1CCCCC1 10.1038/s41467-023-40064-9
3081361 93932 123 None -17 14 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 474 5 1 5 4.4 COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 10.1038/s41467-023-40064-9
CHEMBL24828 93932 123 None -17 14 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 474 5 1 5 4.4 COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 10.1038/s41467-023-40064-9
20628 96546 28 None -28 13 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 324 6 1 5 3.7 CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12 10.1038/s41467-023-40064-9
CHEMBL26291 96546 28 None -28 13 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 324 6 1 5 3.7 CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12 10.1038/s41467-023-40064-9
216416 111579 48 None -128 23 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 413 6 1 3 5.7 Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
CHEMBL328190 111579 48 None -128 23 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 413 6 1 3 5.7 Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
2165 203781 71 None -7 8 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 355 6 2 4 5.2 CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O 10.1038/s41467-023-40064-9
3647519 203781 71 None -7 8 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 355 6 2 4 5.2 CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O 10.1038/s41467-023-40064-9
CHEMBL682 203781 71 None -7 8 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 355 6 2 4 5.2 CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O 10.1038/s41467-023-40064-9
10102 2544 88 None 4 4 Human 8.0 pAC50 = 8.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 432 5 1 6 3.4 Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C 10.1038/s41467-023-40064-9
1824 2544 88 None 4 4 Human 8.0 pAC50 = 8.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 432 5 1 6 3.4 Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C 10.1038/s41467-023-40064-9
65906 2544 88 None 4 4 Human 8.0 pAC50 = 8.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 432 5 1 6 3.4 Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C 10.1038/s41467-023-40064-9
CHEMBL94454 2544 88 None 4 4 Human 8.0 pAC50 = 8.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 432 5 1 6 3.4 Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C 10.1038/s41467-023-40064-9
DB12523 2544 88 None 4 4 Human 8.0 pAC50 = 8.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 432 5 1 6 3.4 Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C 10.1038/s41467-023-40064-9
19861 207521 50 None -5 10 Human 7.0 pAC50 = 7.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 290 0 0 2 3.7 CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1 10.1038/s41467-023-40064-9
CHEMBL946 207521 50 None -5 10 Human 7.0 pAC50 = 7.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 290 0 0 2 3.7 CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1 10.1038/s41467-023-40064-9
4031 99311 28 None -1 12 Human 6.0 pAC50 = 6.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 429 13 0 6 4.6 CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1 10.1038/s41467-023-40064-9
CHEMBL282121 99311 28 None -1 12 Human 6.0 pAC50 = 6.0 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 429 13 0 6 4.6 CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1 10.1038/s41467-023-40064-9
9822750 78407 65 None -2 8 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 408 8 2 7 2.3 CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl 10.1038/s41467-023-40064-9
CHEMBL2111097 78407 65 None -2 8 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 408 8 2 7 2.3 CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl 10.1038/s41467-023-40064-9
216237 3841 89 None -1000 7 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1038/s41467-023-40064-9
2226 3841 89 None -1000 7 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1038/s41467-023-40064-9
4110 3841 89 None -1000 7 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1038/s41467-023-40064-9
CHEMBL344159 3841 89 None -1000 7 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1038/s41467-023-40064-9
6324616 168822 25 None -1 3 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 697 2 6 12 4.8 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(cc(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL437765 168822 25 None -1 3 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 697 2 6 12 4.8 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(cc(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
119607 206201 113 None -1 6 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 314 3 1 4 3.0 Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 10.1038/s41467-023-40064-9
CHEMBL865 206201 113 None -1 6 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 314 3 1 4 3.0 Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 10.1038/s41467-023-40064-9
1209 1656 75 None -51 20 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
203 1656 75 None -51 20 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
3386 1656 75 None -51 20 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL41 1656 75 None -51 20 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
DB00472 1656 75 None -51 20 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
3627 44127 18 None -1 9 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 314 3 0 2 4.1 CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1038/s41467-023-40064-9
CHEMBL1515447 44127 18 None -1 9 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 314 3 0 2 4.1 CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1038/s41467-023-40064-9
3000322 3560 38 None 1 3 Human 7.9 pAC50 = 7.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 4 1 5 0.9 OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C 10.1038/s41467-023-40064-9
330 3560 38 None 1 3 Human 7.9 pAC50 = 7.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 4 1 5 0.9 OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C 10.1038/s41467-023-40064-9
CHEMBL569713 3560 38 None 1 3 Human 7.9 pAC50 = 7.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 4 1 5 0.9 OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C 10.1038/s41467-023-40064-9
DB00747 3560 38 None 1 3 Human 7.9 pAC50 = 7.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 4 1 5 0.9 OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C 10.1038/s41467-023-40064-9
11976 919 59 None -39 16 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
667467 919 59 None -39 16 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
CHEMBL908 919 59 None -39 16 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
DB01239 919 59 None -39 16 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
6127 14497 8 None -1 6 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 278 2 0 0 4.4 C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
CHEMBL1201340 14497 8 None -1 6 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 278 2 0 0 4.4 C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
4940 14468 35 None -4 15 Human 6.9 pAC50 = 6.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 340 5 0 4 4.8 CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2 10.1038/s41467-023-40064-9
CHEMBL1201210 14468 35 None -4 15 Human 6.9 pAC50 = 6.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 340 5 0 4 4.8 CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2 10.1038/s41467-023-40064-9
1224 1431 83 None -416 22 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 0 2 3.4 CN(CCOC(c1ccccc1)c1ccccc1)C 10.1038/s41467-023-40064-9
3100 1431 83 None -416 22 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 0 2 3.4 CN(CCOC(c1ccccc1)c1ccccc1)C 10.1038/s41467-023-40064-9
8980 1431 83 None -416 22 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 0 2 3.4 CN(CCOC(c1ccccc1)c1ccccc1)C 10.1038/s41467-023-40064-9
916 1431 83 None -416 22 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 0 2 3.4 CN(CCOC(c1ccccc1)c1ccccc1)C 10.1038/s41467-023-40064-9
CHEMBL657 1431 83 None -416 22 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 0 2 3.4 CN(CCOC(c1ccccc1)c1ccccc1)C 10.1038/s41467-023-40064-9
DB01075 1431 83 None -416 22 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 255 6 0 2 3.4 CN(CCOC(c1ccccc1)c1ccccc1)C 10.1038/s41467-023-40064-9
2284 3180 33 None -93 34 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
4926 3180 33 None -93 34 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
7281 3180 33 None -93 34 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
CHEMBL564 3180 33 None -93 34 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
DB00420 3180 33 None -93 34 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
16722836 18983 99 None 2 13 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 524 10 3 8 4.8 Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 10.1038/s41467-023-40064-9
CHEMBL1287853 18983 99 None 2 13 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 524 10 3 8 4.8 Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 10.1038/s41467-023-40064-9
16351 102728 47 None -114 17 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 343 0 0 4 4.1 CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1 10.1038/s41467-023-40064-9
CHEMBL304902 102728 47 None -114 17 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 343 0 0 4 4.1 CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1 10.1038/s41467-023-40064-9
260 3867 54 None -12 9 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 2 1 3 3.0 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 10.1038/s41467-023-40064-9
2775 3867 54 None -12 9 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 2 1 3 3.0 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 10.1038/s41467-023-40064-9
656665 3867 54 None -12 9 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 2 1 3 3.0 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL56564 3867 54 None -12 9 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 2 1 3 3.0 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB11699 3867 54 None -12 9 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 2 1 3 3.0 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2 10.1038/s41467-023-40064-9
1549120 196484 85 None -7 19 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 319 4 1 4 2.9 CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL56337 196484 85 None -7 19 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 319 4 1 4 2.9 CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 10.1038/s41467-023-40064-9
9429 202131 58 None -645 18 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 446 6 0 6 3.2 CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1 10.1038/s41467-023-40064-9
CHEMBL609109 202131 58 None -645 18 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 446 6 0 6 3.2 CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1 10.1038/s41467-023-40064-9
24821094 67092 93 None -1 8 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 440 5 1 7 4.2 C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 10.1038/s41467-023-40064-9
CHEMBL1873475 67092 93 None -1 8 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 440 5 1 7 4.2 C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 10.1038/s41467-023-40064-9
1712095 195390 30 None -2 4 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 397 9 1 5 4.9 CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC 10.1038/s41467-023-40064-9
CHEMBL551978 195390 30 None -2 4 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 397 9 1 5 4.9 CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC 10.1038/s41467-023-40064-9
5583 13042 51 None -10 6 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 369 6 3 8 2.7 COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC 10.1038/s41467-023-40064-9
CHEMBL119 13042 51 None -10 6 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 369 6 3 8 2.7 COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC 10.1038/s41467-023-40064-9
1909 2820 64 None -2 11 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 479 9 1 8 3.7 COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C 10.1038/s41467-023-40064-9
2559 2820 64 None -2 11 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 479 9 1 8 3.7 COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C 10.1038/s41467-023-40064-9
4474 2820 64 None -2 11 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 479 9 1 8 3.7 COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C 10.1038/s41467-023-40064-9
CHEMBL1484 2820 64 None -2 11 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 479 9 1 8 3.7 COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C 10.1038/s41467-023-40064-9
CHEMBL3302409 2820 64 None -2 11 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 479 9 1 8 3.7 COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C 10.1038/s41467-023-40064-9
DB00622 2820 64 None -2 11 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 479 9 1 8 3.7 COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C 10.1038/s41467-023-40064-9
25382 9155 37 None -3 21 Human 6.9 pAC50 = 6.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 291 3 0 1 4.7 CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL110094 9155 37 None -3 21 Human 6.9 pAC50 = 6.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 291 3 0 1 4.7 CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21 10.1038/s41467-023-40064-9
92727 204550 77 None -2 6 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 628 15 4 5 4.3 Cc1cccc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N1CCCNC1=O 10.1038/s41467-023-40064-9
CHEMBL729 204550 77 None -2 6 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 628 15 4 5 4.3 Cc1cccc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N1CCCNC1=O 10.1038/s41467-023-40064-9
2865 4141 73 None -6760 20 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
59 4141 73 None -6760 20 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
60854 4141 73 None -6760 20 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL708 4141 73 None -6760 20 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
DB00246 4141 73 None -6760 20 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL4743867 214031 14 None -2137 15 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL None None None OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1 10.1038/s41467-023-40064-9
2794 19378 85 None -14 7 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 472 4 1 4 7.5 CC(C)/N=c1\cc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2cc1Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1292 19378 85 None -14 7 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 472 4 1 4 7.5 CC(C)/N=c1\cc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2cc1Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
4746 204889 31 None -5 19 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 4 1 1 5.3 C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1 10.1038/s41467-023-40064-9
CHEMBL1334033 204889 31 None -5 19 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 4 1 1 5.3 C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1 10.1038/s41467-023-40064-9
CHEMBL75880 204889 31 None -5 19 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 4 1 1 5.3 C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1 10.1038/s41467-023-40064-9
16363 595 53 None -2454 21 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
312 595 53 None -2454 21 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
9215 595 53 None -2454 21 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL297302 595 53 None -2454 21 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB12867 595 53 None -2454 21 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
2771 195015 74 None -173 16 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 10.1038/s41467-023-40064-9
CHEMBL1200781 195015 74 None -173 16 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 10.1038/s41467-023-40064-9
CHEMBL549 195015 74 None -173 16 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 10.1038/s41467-023-40064-9
3775 14473 26 None -2 3 Human 7.9 pAC50 = 7.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 353 8 1 1 4.1 CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
CHEMBL1201232 14473 26 None -2 3 Human 7.9 pAC50 = 7.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 353 8 1 1 4.1 CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
72093 35059 9 None -1 28 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL1433361 35059 9 None -1 28 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL2103773 35059 9 None -1 28 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
9846332 52057 37 None 1 3 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 444 2 3 5 2.4 C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C(Cl)=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO 10.1038/s41467-023-40064-9
CHEMBL1587228 52057 37 None 1 3 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 444 2 3 5 2.4 C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C(Cl)=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO 10.1038/s41467-023-40064-9
1054 2915 85 None -43 5 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 282 15 1 1 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)O 10.1038/s41467-023-40064-9
3400 2915 85 None -43 5 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 282 15 1 1 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)O 10.1038/s41467-023-40064-9
445639 2915 85 None -43 5 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 282 15 1 1 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)O 10.1038/s41467-023-40064-9
CHEMBL8659 2915 85 None -43 5 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 282 15 1 1 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)O 10.1038/s41467-023-40064-9
392622 56310 95 None -11 20 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
CHEMBL163 56310 95 None -11 20 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
37464 19219 26 None -3715 8 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 291 6 2 3 3.5 CC(C)(C)NC[C@H](O)COc1ccccc1C1CCCC1 10.1038/s41467-023-40064-9
CHEMBL1290 19219 26 None -3715 8 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 291 6 2 3 3.5 CC(C)(C)NC[C@H](O)COc1ccccc1C1CCCC1 10.1038/s41467-023-40064-9
3952 1886 38 None -1548 21 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 10.1038/s41467-023-40064-9
5353646 1886 38 None -1548 21 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 10.1038/s41467-023-40064-9
5443 1886 38 None -1548 21 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 10.1038/s41467-023-40064-9
5702063 1886 38 None -1548 21 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 10.1038/s41467-023-40064-9
CHEMBL1331786 1886 38 None -1548 21 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 10.1038/s41467-023-40064-9
CHEMBL420 1886 38 None -1548 21 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N 10.1038/s41467-023-40064-9
44591583 184534 96 None -3 2 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 251 2 1 4 1.6 N#Cc1ccc(Oc2ccc3c(c2)COB3O)cc1 10.1038/s41467-023-40064-9
CHEMBL484785 184534 96 None -3 2 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 251 2 1 4 1.6 N#Cc1ccc(Oc2ccc3c(c2)COB3O)cc1 10.1038/s41467-023-40064-9
6989 100950 115 None -1 3 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 150 1 1 1 2.8 Cc1ccc(C(C)C)c(O)c1 10.1038/s41467-023-40064-9
CHEMBL29411 100950 115 None -1 3 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 150 1 1 1 2.8 Cc1ccc(C(C)C)c(O)c1 10.1038/s41467-023-40064-9
5354 155654 21 None -66 10 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 337 12 2 3 5.6 CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1 10.1038/s41467-023-40064-9
CHEMBL404849 155654 21 None -66 10 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 337 12 2 3 5.6 CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1 10.1038/s41467-023-40064-9
11693 1825 16 None -4 7 Human 7.8 pAC50 = 7.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 1 3 2.5 O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C 10.1038/s41467-023-40064-9
3494 1825 16 None -4 7 Human 7.8 pAC50 = 7.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 1 3 2.5 O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C 10.1038/s41467-023-40064-9
4302 1825 16 None -4 7 Human 7.8 pAC50 = 7.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 1 3 2.5 O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C 10.1038/s41467-023-40064-9
7459 1825 16 None -4 7 Human 7.8 pAC50 = 7.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 1 3 2.5 O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C 10.1038/s41467-023-40064-9
CHEMBL1201335 1825 16 None -4 7 Human 7.8 pAC50 = 7.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 1 3 2.5 O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C 10.1038/s41467-023-40064-9
DB00986 1825 16 None -4 7 Human 7.8 pAC50 = 7.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 1 3 2.5 O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C 10.1038/s41467-023-40064-9
2774 3866 95 None -25 5 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 6 1 3 2.2 CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1 10.1038/s41467-023-40064-9
5593 3866 95 None -25 5 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 6 1 3 2.2 CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1 10.1038/s41467-023-40064-9
7319 3866 95 None -25 5 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 6 1 3 2.2 CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1 10.1038/s41467-023-40064-9
CHEMBL1200604 3866 95 None -25 5 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 6 1 3 2.2 CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1 10.1038/s41467-023-40064-9
DB00809 3866 95 None -25 5 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 6 1 3 2.2 CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1 10.1038/s41467-023-40064-9
DB01199 3866 95 None -25 5 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 284 6 1 3 2.2 CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1 10.1038/s41467-023-40064-9
4011 82406 49 None -109 26 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 10.1038/s41467-023-40064-9
CHEMBL21731 82406 49 None -109 26 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 10.1038/s41467-023-40064-9
23480 124088 23 None -1 7 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 5 1 1 5.0 CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C 10.1038/s41467-023-40064-9
CHEMBL363295 124088 23 None -1 7 Human 5.9 pAC50 = 5.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 5 1 1 5.0 CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C 10.1038/s41467-023-40064-9
2267 559 71 None -32 14 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
271 559 71 None -32 14 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
7121 559 71 None -32 14 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
CHEMBL639 559 71 None -32 14 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
DB00972 559 71 None -32 14 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
68867 78171 38 None -676 13 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 402 7 2 6 3.1 CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1 10.1038/s41467-023-40064-9
CHEMBL2104523 78171 38 None -676 13 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 402 7 2 6 3.1 CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1 10.1038/s41467-023-40064-9
55483 205095 40 None -89 11 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 356 13 4 4 3.6 Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O 10.1038/s41467-023-40064-9
CHEMBL77622 205095 40 None -89 11 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 356 13 4 4 3.6 Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O 10.1038/s41467-023-40064-9
CHEMBL4743867 214031 14 None -2137 15 Human 4.9 pAC50 = 4.9 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1 10.1038/s41467-023-40064-9
64143 198862 62 None -2 10 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 567 9 4 6 4.7 Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C 10.1038/s41467-023-40064-9
CHEMBL584 198862 62 None -2 10 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 567 9 4 6 4.7 Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C 10.1038/s41467-023-40064-9
30323 62483 57 None -7 21 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 527 4 5 11 1.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
CHEMBL1563 62483 57 None -7 21 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 527 4 5 11 1.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
CHEMBL178 62483 57 None -7 21 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 527 4 5 11 1.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
3658 4105 53 None -1513 18 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
517 4105 53 None -1513 18 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
5709 4105 53 None -1513 18 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
CHEMBL312448 4105 53 None -1513 18 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
DB06694 4105 53 None -1513 18 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
1613 2346 53 None -52 34 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
205 2346 53 None -52 34 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
3964 2346 53 None -52 34 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
CHEMBL831 2346 53 None -52 34 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
DB00408 2346 53 None -52 34 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
2218 15281 23 None -18 12 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 322 8 0 2 4.4 CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1 10.1038/s41467-023-40064-9
CHEMBL1213033 15281 23 None -18 12 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 322 8 0 2 4.4 CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1 10.1038/s41467-023-40064-9
3735 206229 76 None 1 3 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 571 4 2 2 3.7 CCC(Cc1c(I)cc(I)c(N)c1I)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL867 206229 76 None 1 3 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 571 4 2 2 3.7 CCC(Cc1c(I)cc(I)c(N)c1I)C(=O)O 10.1038/s41467-023-40064-9
2398 953 62 None -151 36 Human 6.8 pAC50 = 6.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
2801 953 62 None -151 36 Human 6.8 pAC50 = 6.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
701 953 62 None -151 36 Human 6.8 pAC50 = 6.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
CHEMBL415 953 62 None -151 36 Human 6.8 pAC50 = 6.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
DB01242 953 62 None -151 36 Human 6.8 pAC50 = 6.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
1570 57297 97 None -2 3 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 127 0 1 3 1.5 On1ccccc1=S 10.1038/s41467-023-40064-9
CHEMBL1650619 57297 97 None -2 3 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 127 0 1 3 1.5 On1ccccc1=S 10.1038/s41467-023-40064-9
444795 139997 105 None -41 6 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 300 5 1 1 5.6 CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 10.1038/s41467-023-40064-9
CHEMBL38 139997 105 None -41 6 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 300 5 1 1 5.6 CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 10.1038/s41467-023-40064-9
2444 14476 26 None -1 8 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 333 6 0 2 4.1 CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1 10.1038/s41467-023-40064-9
CHEMBL1201245 14476 26 None -1 8 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 333 6 0 2 4.1 CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1 10.1038/s41467-023-40064-9
6918178 14443 44 None -1 3 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 484 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL1200908 14443 44 None -1 3 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 484 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 10.1038/s41467-023-40064-9
4919 206232 23 None 1 5 Human 6.8 pAC50 = 6.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 287 5 1 2 3.9 OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1 10.1038/s41467-023-40064-9
CHEMBL86715 206232 23 None 1 5 Human 6.8 pAC50 = 6.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 287 5 1 2 3.9 OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1 10.1038/s41467-023-40064-9
2166 3121 49 None -3 10 Human 5.8 pAC50 = 5.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (NIBR assay) measured by Hamamatsu Functional Drug Screening SystemAgonist activity at human CHRM1 in an in vitro cell-based assay (NIBR assay) measured by Hamamatsu Functional Drug Screening System
ChEMBL 208 3 0 4 1.2 CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C 10.1038/s41467-023-40064-9
305 3121 49 None -3 10 Human 5.8 pAC50 = 5.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (NIBR assay) measured by Hamamatsu Functional Drug Screening SystemAgonist activity at human CHRM1 in an in vitro cell-based assay (NIBR assay) measured by Hamamatsu Functional Drug Screening System
ChEMBL 208 3 0 4 1.2 CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C 10.1038/s41467-023-40064-9
5910 3121 49 None -3 10 Human 5.8 pAC50 = 5.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (NIBR assay) measured by Hamamatsu Functional Drug Screening SystemAgonist activity at human CHRM1 in an in vitro cell-based assay (NIBR assay) measured by Hamamatsu Functional Drug Screening System
ChEMBL 208 3 0 4 1.2 CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C 10.1038/s41467-023-40064-9
CHEMBL550 3121 49 None -3 10 Human 5.8 pAC50 = 5.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (NIBR assay) measured by Hamamatsu Functional Drug Screening SystemAgonist activity at human CHRM1 in an in vitro cell-based assay (NIBR assay) measured by Hamamatsu Functional Drug Screening System
ChEMBL 208 3 0 4 1.2 CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C 10.1038/s41467-023-40064-9
DB01085 3121 49 None -3 10 Human 5.8 pAC50 = 5.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (NIBR assay) measured by Hamamatsu Functional Drug Screening SystemAgonist activity at human CHRM1 in an in vitro cell-based assay (NIBR assay) measured by Hamamatsu Functional Drug Screening System
ChEMBL 208 3 0 4 1.2 CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C 10.1038/s41467-023-40064-9
43815 186918 64 None -4 20 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1038/s41467-023-40064-9
CHEMBL1708 186918 64 None -4 20 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1038/s41467-023-40064-9
CHEMBL490 186918 64 None -4 20 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1038/s41467-023-40064-9
115163 57301 44 None -4 2 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 439 5 0 7 2.4 CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2C(=O)[C@@H](/N=C/N3CCCCCC3)[C@H]2SC1(C)C 10.1038/s41467-023-40064-9
CHEMBL1650818 57301 44 None -4 2 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 439 5 0 7 2.4 CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2C(=O)[C@@H](/N=C/N3CCCCCC3)[C@H]2SC1(C)C 10.1038/s41467-023-40064-9
70695647 78211 0 None -30 3 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 300 2 1 1 5.3 C=CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCCC4[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL2105618 78211 0 None -30 3 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 300 2 1 1 5.3 C=CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCCC4[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
31101 728 40 None -5370 29 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
35 728 40 None -5370 29 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
403 728 40 None -5370 29 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
CHEMBL493 728 40 None -5370 29 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
DB01200 728 40 None -5370 29 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
6077 150696 31 None -50 11 Human 6.8 pAC50 = 6.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 326 5 0 4 4.4 CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2 10.1038/s41467-023-40064-9
CHEMBL39560 150696 31 None -50 11 Human 6.8 pAC50 = 6.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 326 5 0 4 4.4 CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2 10.1038/s41467-023-40064-9
CHEMBL4743867 214031 14 None -2137 15 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL None None None OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1 10.1038/s41467-023-40064-9
19090 156816 46 None - 1 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 342 1 1 3 4.0 CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL4071215 156816 46 None - 1 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 342 1 1 3 4.0 CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
71743 78265 62 None 1 4 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 353 3 0 4 3.6 O=C(Oc1ccc2c(c1)CCCN2C(=O)C(Cl)Cl)c1ccco1 10.1038/s41467-023-40064-9
CHEMBL2107014 78265 62 None 1 4 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 353 3 0 4 3.6 O=C(Oc1ccc2c(c1)CCCN2C(=O)C(Cl)Cl)c1ccco1 10.1038/s41467-023-40064-9
18609376 204357 63 None -6 4 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 386 2 0 4 4.7 CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
6279 204357 63 None -6 4 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 386 2 0 4 4.7 CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL717 204357 63 None -6 4 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 386 2 0 4 4.7 CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
151537 162662 49 None -1 5 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 543 5 6 12 0.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
41867 162662 49 None -1 5 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 543 5 6 12 0.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
CHEMBL417 162662 49 None -1 5 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 543 5 6 12 0.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
CHEMBL1630575 56341 0 None -3 6 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 1093 23 16 18 -3.3 CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O 10.1038/s41467-023-40064-9
1440 2025 119 None -40 7 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 357 4 1 4 3.9 COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
1909 2025 119 None -40 7 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 357 4 1 4 3.9 COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
3715 2025 119 None -40 7 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 357 4 1 4 3.9 COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
CHEMBL6 2025 119 None -40 7 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 357 4 1 4 3.9 COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
DB00328 2025 119 None -40 7 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 357 4 1 4 3.9 COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
135398737 957 93 None -6 43 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
38 957 93 None -6 43 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
722 957 93 None -6 43 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL42 957 93 None -6 43 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
DB00363 957 93 None -6 43 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
1371 1921 11 None 4 2 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 317 4 1 2 2.8 C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O 10.1038/s41467-023-40064-9
24199 1921 11 None 4 2 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 317 4 1 2 2.8 C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O 10.1038/s41467-023-40064-9
323 1921 11 None 4 2 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 317 4 1 2 2.8 C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O 10.1038/s41467-023-40064-9
CHEMBL1201325 1921 11 None 4 2 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 317 4 1 2 2.8 C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O 10.1038/s41467-023-40064-9
DB06787 1921 11 None 4 2 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 317 4 1 2 2.8 C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O 10.1038/s41467-023-40064-9
2131 57405 25 None -2 7 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 536 14 2 2 4.6 CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)Cc1ccccc1Cl)Cc1ccccc1Cl 10.1038/s41467-023-40064-9
CHEMBL1652 57405 25 None -2 7 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 536 14 2 2 4.6 CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)Cc1ccccc1Cl)Cc1ccccc1Cl 10.1038/s41467-023-40064-9
5440 28722 37 None -6918 16 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 399 6 0 5 5.0 CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2 10.1038/s41467-023-40064-9
CHEMBL1378 28722 37 None -6918 16 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 399 6 0 5 5.0 CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2 10.1038/s41467-023-40064-9
134018 10468 122 None - 1 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 316 5 1 5 3.7 Cc1nc(-c2ccc(OCC(C)C)c(C#N)c2)sc1C(=O)O 10.1038/s41467-023-40064-9
CHEMBL1164729 10468 122 None - 1 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 316 5 1 5 3.7 Cc1nc(-c2ccc(OCC(C)C)c(C#N)c2)sc1C(=O)O 10.1038/s41467-023-40064-9
49843517 78292 41 None -48 8 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 590 13 2 6 8.5 CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC 10.1038/s41467-023-40064-9
CHEMBL2107831 78292 41 None -48 8 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 590 13 2 6 8.5 CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC 10.1038/s41467-023-40064-9
176870 195483 106 None 5 6 Human 5.8 pAC50 = 5.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 393 10 1 7 3.4 C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 10.1038/s41467-023-40064-9
CHEMBL553 195483 106 None 5 6 Human 5.8 pAC50 = 5.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 393 10 1 7 3.4 C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 10.1038/s41467-023-40064-9
5625 199666 72 None -1 5 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 456 6 3 6 2.7 CC(C)Nc1cccnc1N1CCN(C(=O)c2cc3cc(NS(C)(=O)=O)ccc3[nH]2)CC1 10.1038/s41467-023-40064-9
CHEMBL593 199666 72 None -1 5 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 456 6 3 6 2.7 CC(C)Nc1cccnc1N1CCN(C(=O)c2cc3cc(NS(C)(=O)=O)ccc3[nH]2)CC1 10.1038/s41467-023-40064-9
3280 48447 28 None 1 8 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 395 10 0 5 5.4 CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC 10.1038/s41467-023-40064-9
CHEMBL1555736 48447 28 None 1 8 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 395 10 0 5 5.4 CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC 10.1038/s41467-023-40064-9
6314185 191404 20 None -7 3 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 353 7 1 2 5.2 CCNC(=O)/C=C(C)/C=C/C=C(C)/C=C/c1c(C)cc(OC)c(C)c1C 10.1038/s41467-023-40064-9
CHEMBL519260 191404 20 None -7 3 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 353 7 1 2 5.2 CCNC(=O)/C=C(C)/C=C/C=C(C)/C=C/c1c(C)cc(OC)c(C)c1C 10.1038/s41467-023-40064-9
3463 175144 107 None -3 4 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 250 6 1 2 3.6 Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1 10.1038/s41467-023-40064-9
CHEMBL457 175144 107 None -3 4 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 250 6 1 2 3.6 Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1 10.1038/s41467-023-40064-9
1353 1909 93 None -2187 39 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
3559 1909 93 None -2187 39 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
86 1909 93 None -2187 39 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
CHEMBL54 1909 93 None -2187 39 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
DB00502 1909 93 None -2187 39 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
2726 918 68 None -177 42 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
621 918 68 None -177 42 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
83 918 68 None -177 42 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
CHEMBL71 918 68 None -177 42 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
DB00477 918 68 None -177 42 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
4037 189014 60 None -1 4 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 295 3 2 2 4.7 Cc1ccc(Cl)c(Nc2ccccc2C(=O)O)c1Cl 10.1038/s41467-023-40064-9
CHEMBL509 189014 60 None -1 4 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 295 3 2 2 4.7 Cc1ccc(Cl)c(Nc2ccccc2C(=O)O)c1Cl 10.1038/s41467-023-40064-9
CHEMBL876 189014 60 None -1 4 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 295 3 2 2 4.7 Cc1ccc(Cl)c(Nc2ccccc2C(=O)O)c1Cl 10.1038/s41467-023-40064-9
3042 1413 35 None -5 17 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 309 7 0 3 4.4 CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC 10.1038/s41467-023-40064-9
355 1413 35 None -5 17 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 309 7 0 3 4.4 CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC 10.1038/s41467-023-40064-9
868 1413 35 None -5 17 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 309 7 0 3 4.4 CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC 10.1038/s41467-023-40064-9
CHEMBL1123 1413 35 None -5 17 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 309 7 0 3 4.4 CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC 10.1038/s41467-023-40064-9
DB00804 1413 35 None -5 17 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 309 7 0 3 4.4 CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC 10.1038/s41467-023-40064-9
277 1300 62 None -16 29 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1038/s41467-023-40064-9
2913 1300 62 None -16 29 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1038/s41467-023-40064-9
765 1300 62 None -16 29 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1038/s41467-023-40064-9
CHEMBL516 1300 62 None -16 29 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1038/s41467-023-40064-9
DB00434 1300 62 None -16 29 Human 7.8 pAC50 = 7.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 10.1038/s41467-023-40064-9
657202 12528 6 None -4 4 Human 6.8 pAC50 = 6.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 282 6 0 2 3.5 CCCC(CCC)C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C 10.1038/s41467-023-40064-9
CHEMBL1186610 12528 6 None -4 4 Human 6.8 pAC50 = 6.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 282 6 0 2 3.5 CCCC(CCC)C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C 10.1038/s41467-023-40064-9
191 403 98 None -239 36 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
201 403 98 None -239 36 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
2170 403 98 None -239 36 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
CHEMBL1113 403 98 None -239 36 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
DB00543 403 98 None -239 36 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
1530 2180 50 None -100 25 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.1038/s41467-023-40064-9
3827 2180 50 None -100 25 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.1038/s41467-023-40064-9
7206 2180 50 None -100 25 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.1038/s41467-023-40064-9
CHEMBL534 2180 50 None -100 25 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.1038/s41467-023-40064-9
DB00920 2180 50 None -100 25 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.1038/s41467-023-40064-9
4942 5716 50 None -1 11 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 367 7 0 4 4.0 CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1078261 5716 50 None -1 11 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 367 7 0 4 4.0 CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
156419 937 74 None -269 15 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
3308 937 74 None -269 15 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
647 937 74 None -269 15 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL1201284 937 74 None -269 15 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
DB01012 937 74 None -269 15 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
3157 1469 71 None -16982 22 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
7170 1469 71 None -16982 22 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
954 1469 71 None -16982 22 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
CHEMBL707 1469 71 None -16982 22 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
DB00590 1469 71 None -16982 22 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
8609 14442 66 None 1 4 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 229 2 2 4 2.2 Nc1ccc(C(=O)Oc2ccccc2)c(O)c1 10.1038/s41467-023-40064-9
CHEMBL1200868 14442 66 None 1 4 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 229 2 2 4 2.2 Nc1ccc(C(=O)Oc2ccccc2)c(O)c1 10.1038/s41467-023-40064-9
4886 14108 28 None -7 5 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 293 9 0 4 3.0 CCCCOc1ccc(OCCCN2CCOCC2)cc1 10.1038/s41467-023-40064-9
CHEMBL1198 14108 28 None -7 5 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 293 9 0 4 3.0 CCCCOc1ccc(OCCCN2CCOCC2)cc1 10.1038/s41467-023-40064-9
16222096 80481 67 None -64 7 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 531 4 3 4 3.8 O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1 10.1038/s41467-023-40064-9
CHEMBL2146883 80481 67 None -64 7 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 531 4 3 4 3.8 O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1 10.1038/s41467-023-40064-9
3634 84106 51 None -12 9 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 356 7 2 5 3.7 CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12 10.1038/s41467-023-40064-9
CHEMBL22077 84106 51 None -12 9 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 356 7 2 5 3.7 CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12 10.1038/s41467-023-40064-9
2910 202684 57 None - 1 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 389 2 3 5 1.2 NS(=O)(=O)c1cc2c(cc1Cl)NC(C1CC3C=CC1C3)NS2(=O)=O 10.1038/s41467-023-40064-9
CHEMBL61593 202684 57 None - 1 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 389 2 3 5 1.2 NS(=O)(=O)c1cc2c(cc1Cl)NC(C1CC3C=CC1C3)NS2(=O)=O 10.1038/s41467-023-40064-9
2898 32649 73 None -7 3 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 364 4 0 4 5.3 CC(=O)Oc1ccc(C(=C2CCCCC2)c2ccc(OC(C)=O)cc2)cc1 10.1038/s41467-023-40064-9
CHEMBL141305 32649 73 None -7 3 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 364 4 0 4 5.3 CC(=O)Oc1ccc(C(=C2CCCCC2)c2ccc(OC(C)=O)cc2)cc1 10.1038/s41467-023-40064-9
2583 3774 118 None -10000 16 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
592 3774 118 None -10000 16 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
65999 3774 118 None -10000 16 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
CHEMBL1017 3774 118 None -10000 16 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
DB00966 3774 118 None -10000 16 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
5744 8048 69 None - 1 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 404 3 2 6 2.4 CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL1091 8048 69 None - 1 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 404 3 2 6 2.4 CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C 10.1038/s41467-023-40064-9
60663 175667 42 None -23 12 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 495 11 1 5 5.3 COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C 10.1038/s41467-023-40064-9
CHEMBL1421212 175667 42 None -23 12 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 495 11 1 5 5.3 COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C 10.1038/s41467-023-40064-9
CHEMBL1534525 175667 42 None -23 12 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 495 11 1 5 5.3 COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C 10.1038/s41467-023-40064-9
CHEMBL45816 175667 42 None -23 12 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 495 11 1 5 5.3 COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C 10.1038/s41467-023-40064-9
2683 102886 25 None -75 24 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 10.1038/s41467-023-40064-9
CHEMBL305906 102886 25 None -75 24 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 10.1038/s41467-023-40064-9
CHEMBL334255 102886 25 None -75 24 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 10.1038/s41467-023-40064-9
131411 15390 70 None -6 10 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 476 7 1 6 5.2 CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12 10.1038/s41467-023-40064-9
28446253 15390 70 None -6 10 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 476 7 1 6 5.2 CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12 10.1038/s41467-023-40064-9
CHEMBL1214598 15390 70 None -6 10 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 476 7 1 6 5.2 CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12 10.1038/s41467-023-40064-9
5318 15574 49 None -4 18 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1200348 15574 49 None -4 18 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1221 15574 49 None -4 18 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 10.1038/s41467-023-40064-9
60065 84367 6 None -11 11 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 505 7 1 8 4.2 COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@@H]2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
CHEMBL2218858 84367 6 None -11 11 Human 4.8 pAC50 = 4.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 505 7 1 8 4.2 COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@@H]2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
11434515 261 6 None -1 11 Human 7.8 pAC50 = 7.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
11519741 261 6 None -1 11 Human 7.8 pAC50 = 7.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
4484 261 6 None -1 11 Human 7.8 pAC50 = 7.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
7449 261 6 None -1 11 Human 7.8 pAC50 = 7.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
CHEMBL1194325 261 6 None -1 11 Human 7.8 pAC50 = 7.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
DB08897 261 6 None -1 11 Human 7.8 pAC50 = 7.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
2895 203590 41 None -1 15 Human 6.8 pAC50 = 6.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 275 3 0 1 4.6 CN(C)CCC=C1c2ccccc2C=Cc2ccccc21 10.1038/s41467-023-40064-9
CHEMBL669 203590 41 None -1 15 Human 6.8 pAC50 = 6.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 275 3 0 1 4.6 CN(C)CCC=C1c2ccccc2C=Cc2ccccc21 10.1038/s41467-023-40064-9
242 470 124 None -741 33 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
34 470 124 None -741 33 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
60795 470 124 None -741 33 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
CHEMBL1112 470 124 None -741 33 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
DB01238 470 124 None -741 33 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
1228 3864 34 None -100 6 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 278 4 0 2 3.9 Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 10.1038/s41467-023-40064-9
2763 3864 34 None -100 6 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 278 4 0 2 3.9 Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 10.1038/s41467-023-40064-9
5282443 3864 34 None -100 6 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 278 4 0 2 3.9 Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 10.1038/s41467-023-40064-9
CHEMBL855 3864 34 None -100 6 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 278 4 0 2 3.9 Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 10.1038/s41467-023-40064-9
DB00427 3864 34 None -100 6 Human 5.8 pAC50 = 5.8 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 278 4 0 2 3.9 Cc1ccc(cc1)/C(=C\CN1CCCC1)/c1ccccn1 10.1038/s41467-023-40064-9
2335 11846 22 None -14 34 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
8478 11846 22 None -14 34 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL1182210 11846 22 None -14 34 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL221753 11846 22 None -14 34 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
3035016 12592 50 None -1 3 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 483 3 5 10 0.6 CC(=O)[C@]1(N)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](O)[C@H](O)CO2)C1)C(=O)c1ccccc1C3=O 10.1038/s41467-023-40064-9
CHEMBL1186894 12592 50 None -1 3 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 483 3 5 10 0.6 CC(=O)[C@]1(N)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](O)[C@H](O)CO2)C1)C(=O)c1ccccc1C3=O 10.1038/s41467-023-40064-9
34040 28083 72 None -616 11 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 483 4 0 6 3.9 CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13 10.1038/s41467-023-40064-9
CHEMBL1372950 28083 72 None -616 11 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 483 4 0 6 3.9 CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13 10.1038/s41467-023-40064-9
60151560 167440 39 None -1 5 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 439 11 1 5 5.3 CCO[C@@H](Cc1ccc(OCCn2c(C)ccc2-c2ccc(SC)cc2)cc1)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL4297530 167440 39 None -1 5 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 439 11 1 5 5.3 CCO[C@@H](Cc1ccc(OCCn2c(C)ccc2-c2ccc(SC)cc2)cc1)C(=O)O 10.1038/s41467-023-40064-9
2247 505 81 None -338 42 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
249 505 81 None -338 42 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
2603 505 81 None -338 42 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
CHEMBL296419 505 81 None -338 42 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
DB00637 505 81 None -338 42 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
123603 882 29 None -64 5 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 199 0 0 3 1.6 CC1SCC2(O1)CN1CCC2CC1 10.1038/s41467-023-40064-9
2684 882 29 None -64 5 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 199 0 0 3 1.6 CC1SCC2(O1)CN1CCC2CC1 10.1038/s41467-023-40064-9
584 882 29 None -64 5 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 199 0 0 3 1.6 CC1SCC2(O1)CN1CCC2CC1 10.1038/s41467-023-40064-9
9658 882 29 None -64 5 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 199 0 0 3 1.6 CC1SCC2(O1)CN1CCC2CC1 10.1038/s41467-023-40064-9
CHEMBL168815 882 29 None -64 5 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 199 0 0 3 1.6 CC1SCC2(O1)CN1CCC2CC1 10.1038/s41467-023-40064-9
118422671 2755 65 None -6309 23 Human 4.7 pAC50 = 4.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
1887 2755 65 None -6309 23 Human 4.7 pAC50 = 4.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
71301 2755 65 None -6309 23 Human 4.7 pAC50 = 4.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
7246 2755 65 None -6309 23 Human 4.7 pAC50 = 4.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
CHEMBL434394 2755 65 None -6309 23 Human 4.7 pAC50 = 4.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
DB04861 2755 65 None -6309 23 Human 4.7 pAC50 = 4.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
26248 161537 102 None -1 11 Human 4.7 pAC50 = 4.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 368 3 1 7 2.0 CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O 10.1038/s41467-023-40064-9
CHEMBL41286 161537 102 None -1 11 Human 4.7 pAC50 = 4.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 368 3 1 7 2.0 CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O 10.1038/s41467-023-40064-9
4642 41984 28 None 2 3 Human 7.7 pAC50 = 7.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 344 5 1 5 2.7 CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1 10.1038/s41467-023-40064-9
CHEMBL1495 41984 28 None 2 3 Human 7.7 pAC50 = 7.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 344 5 1 5 2.7 CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1 10.1038/s41467-023-40064-9
2337 3254 77 None -162 29 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
50 3254 77 None -162 29 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
5002 3254 77 None -162 29 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL716 3254 77 None -162 29 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
DB01224 3254 77 None -162 29 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
3117 207839 103 None -26 24 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 296 4 0 4 3.6 CCN(CC)C(=S)SSC(=S)N(CC)CC 10.1038/s41467-023-40064-9
CHEMBL964 207839 103 None -26 24 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 296 4 0 4 3.6 CCN(CC)C(=S)SSC(=S)N(CC)CC 10.1038/s41467-023-40064-9
5568 197498 29 None -63 13 Human 6.7 pAC50 = 6.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 352 4 0 3 5.3 CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21 10.1038/s41467-023-40064-9
66069 197498 29 None -63 13 Human 6.7 pAC50 = 6.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 352 4 0 3 5.3 CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21 10.1038/s41467-023-40064-9
CHEMBL1201102 197498 29 None -63 13 Human 6.7 pAC50 = 6.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 352 4 0 3 5.3 CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21 10.1038/s41467-023-40064-9
CHEMBL570 197498 29 None -63 13 Human 6.7 pAC50 = 6.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 352 4 0 3 5.3 CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21 10.1038/s41467-023-40064-9
16362 3123 71 None -208 35 Human 5.7 pAC50 = 5.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
2172 3123 71 None -208 35 Human 5.7 pAC50 = 5.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
90 3123 71 None -208 35 Human 5.7 pAC50 = 5.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL1423 3123 71 None -208 35 Human 5.7 pAC50 = 5.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB01100 3123 71 None -208 35 Human 5.7 pAC50 = 5.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
4034 55820 55 None -45 18 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 390 5 0 2 5.6 Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1 10.1038/s41467-023-40064-9
CHEMBL1623 55820 55 None -45 18 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 390 5 0 2 5.6 Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1 10.1038/s41467-023-40064-9
68921 78240 33 None - 1 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 460 5 1 7 3.3 CCC(=O)O[C@]1(C(=O)COC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL2106309 78240 33 None - 1 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 460 5 1 7 3.3 CCC(=O)O[C@]1(C(=O)COC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C 10.1038/s41467-023-40064-9
22530 56128 58 None -7 9 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 276 2 0 2 3.7 CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1 10.1038/s41467-023-40064-9
CHEMBL1600878 56128 58 None -7 9 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 276 2 0 2 3.7 CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1 10.1038/s41467-023-40064-9
CHEMBL1625607 56128 58 None -7 9 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 276 2 0 2 3.7 CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1 10.1038/s41467-023-40064-9
3678 94790 57 None -6 8 Human 6.7 pAC50 = 6.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 281 9 0 1 4.6 CCN(CCCc1ccccc1)CCCc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL253371 94790 57 None -6 8 Human 6.7 pAC50 = 6.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 281 9 0 1 4.6 CCN(CCCc1ccccc1)CCCc1ccccc1 10.1038/s41467-023-40064-9
21700 592 53 None -3801 5 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 520 6 1 7 4.1 CCC(=O)O[C@@]1([C@@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)Cl)C(=O)COC(=O)CC 10.1038/s41467-023-40064-9
294 592 53 None -3801 5 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 520 6 1 7 4.1 CCC(=O)O[C@@]1([C@@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)Cl)C(=O)COC(=O)CC 10.1038/s41467-023-40064-9
5894 592 53 None -3801 5 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 520 6 1 7 4.1 CCC(=O)O[C@@]1([C@@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)Cl)C(=O)COC(=O)CC 10.1038/s41467-023-40064-9
CHEMBL1200500 592 53 None -3801 5 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 520 6 1 7 4.1 CCC(=O)O[C@@]1([C@@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)Cl)C(=O)COC(=O)CC 10.1038/s41467-023-40064-9
DB00394 592 53 None -3801 5 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 520 6 1 7 4.1 CCC(=O)O[C@@]1([C@@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)Cl)C(=O)COC(=O)CC 10.1038/s41467-023-40064-9
6834 205550 45 None -380 6 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 318 5 0 2 3.9 CN(C)CCC(c1ccc(Br)cc1)c1ccccn1 10.1038/s41467-023-40064-9
CHEMBL811 205550 45 None -380 6 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 318 5 0 2 3.9 CN(C)CCC(c1ccc(Br)cc1)c1ccccn1 10.1038/s41467-023-40064-9
10453870 73660 62 None 1 2 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 404 4 4 6 2.1 OC[C@H]1O[C@@H](c2ccc(F)c(Cc3cc4ccccc4s3)c2)[C@H](O)[C@@H](O)[C@@H]1O 10.1038/s41467-023-40064-9
CHEMBL2018096 73660 62 None 1 2 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 404 4 4 6 2.1 OC[C@H]1O[C@@H](c2ccc(F)c(Cc3cc4ccccc4s3)c2)[C@H](O)[C@@H](O)[C@@H]1O 10.1038/s41467-023-40064-9
15942715 78191 19 None -2 3 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 446 5 1 5 4.0 CCCCOC(=O)C(=O)[C@H]1[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL2105087 78191 19 None -2 3 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 446 5 1 5 4.0 CCCCOC(=O)C(=O)[C@H]1[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C 10.1038/s41467-023-40064-9
11693 1825 16 None -4 7 Human 8.6 pAC50 = 8.6 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 318 4 1 3 2.5 O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C 10.1038/s41467-023-40064-9
3494 1825 16 None -4 7 Human 8.6 pAC50 = 8.6 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 318 4 1 3 2.5 O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C 10.1038/s41467-023-40064-9
4302 1825 16 None -4 7 Human 8.6 pAC50 = 8.6 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 318 4 1 3 2.5 O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C 10.1038/s41467-023-40064-9
7459 1825 16 None -4 7 Human 8.6 pAC50 = 8.6 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 318 4 1 3 2.5 O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C 10.1038/s41467-023-40064-9
CHEMBL1201335 1825 16 None -4 7 Human 8.6 pAC50 = 8.6 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 318 4 1 3 2.5 O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C 10.1038/s41467-023-40064-9
DB00986 1825 16 None -4 7 Human 8.6 pAC50 = 8.6 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 318 4 1 3 2.5 O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C 10.1038/s41467-023-40064-9
5284632 67400 13 None 1 4 Human 8.6 pAC50 = 8.6 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 392 4 1 3 3.8 O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1888176 67400 13 None 1 4 Human 8.6 pAC50 = 8.6 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 392 4 1 3 3.8 O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL3084748 67400 13 None 1 4 Human 8.6 pAC50 = 8.6 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 392 4 1 3 3.8 O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
3000322 3560 38 None 1 3 Human 8.6 pAC50 = 8.6 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 4 1 5 0.9 OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C 10.1038/s41467-023-40064-9
330 3560 38 None 1 3 Human 8.6 pAC50 = 8.6 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 4 1 5 0.9 OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C 10.1038/s41467-023-40064-9
CHEMBL569713 3560 38 None 1 3 Human 8.6 pAC50 = 8.6 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 4 1 5 0.9 OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C 10.1038/s41467-023-40064-9
DB00747 3560 38 None 1 3 Human 8.6 pAC50 = 8.6 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 4 1 5 0.9 OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C 10.1038/s41467-023-40064-9
25897919 55650 14 None -2 5 Human 8.6 pAC50 = 8.6 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 332 5 1 3 2.9 CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2 10.1038/s41467-023-40064-9
657309 55650 14 None -2 5 Human 8.6 pAC50 = 8.6 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 332 5 1 3 2.9 CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2 10.1038/s41467-023-40064-9
CHEMBL1464005 55650 14 None -2 5 Human 8.6 pAC50 = 8.6 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 332 5 1 3 2.9 CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2 10.1038/s41467-023-40064-9
CHEMBL1621597 55650 14 None -2 5 Human 8.6 pAC50 = 8.6 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 332 5 1 3 2.9 CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2 10.1038/s41467-023-40064-9
2705 3840 64 None -1 9 Human 7.7 pAC50 = 7.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 325 7 1 2 5.3 Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O 10.1038/s41467-023-40064-9
360 3840 64 None -1 9 Human 7.7 pAC50 = 7.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 325 7 1 2 5.3 Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O 10.1038/s41467-023-40064-9
443879 3840 64 None -1 9 Human 7.7 pAC50 = 7.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 325 7 1 2 5.3 Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O 10.1038/s41467-023-40064-9
CHEMBL1382 3840 64 None -1 9 Human 7.7 pAC50 = 7.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 325 7 1 2 5.3 Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O 10.1038/s41467-023-40064-9
DB01036 3840 64 None -1 9 Human 7.7 pAC50 = 7.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 325 7 1 2 5.3 Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O 10.1038/s41467-023-40064-9
2865 4141 73 None -6760 20 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
59 4141 73 None -6760 20 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
60854 4141 73 None -6760 20 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL708 4141 73 None -6760 20 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
DB00246 4141 73 None -6760 20 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
2448 99321 70 None -912 15 Human 4.7 pAC50 = 4.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 419 6 1 3 4.5 O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1 10.1038/s41467-023-40064-9
CHEMBL28218 99321 70 None -912 15 Human 4.7 pAC50 = 4.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 419 6 1 3 4.5 O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1 10.1038/s41467-023-40064-9
68704 100731 34 None - 1 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 221 4 2 2 2.5 CC(C)Cc1ccc(C(C)C(=O)NO)cc1 10.1038/s41467-023-40064-9
CHEMBL292707 100731 34 None - 1 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 221 4 2 2 2.5 CC(C)Cc1ccc(C(C)C(=O)NO)cc1 10.1038/s41467-023-40064-9
7019 167974 106 None -4 8 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 194 0 1 2 3.0 Nc1c2ccccc2nc2ccccc12 10.1038/s41467-023-40064-9
CHEMBL1308088 167974 106 None -4 8 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 194 0 1 2 3.0 Nc1c2ccccc2nc2ccccc12 10.1038/s41467-023-40064-9
CHEMBL43184 167974 106 None -4 8 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 194 0 1 2 3.0 Nc1c2ccccc2nc2ccccc12 10.1038/s41467-023-40064-9
5329102 194724 86 None -18 37 Human 5.7 pAC50 = 5.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
CHEMBL535 194724 86 None -18 37 Human 5.7 pAC50 = 5.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
4044 203846 111 None - 1 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 241 3 2 2 3.7 Cc1cccc(Nc2ccccc2C(=O)O)c1C 10.1038/s41467-023-40064-9
CHEMBL686 203846 111 None - 1 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 241 3 2 2 3.7 Cc1cccc(Nc2ccccc2C(=O)O)c1C 10.1038/s41467-023-40064-9
4822 45030 47 None -3 10 Human 7.7 pAC50 = 7.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 293 0 0 2 4.7 CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1 10.1038/s41467-023-40064-9
CHEMBL152408 45030 47 None -3 10 Human 7.7 pAC50 = 7.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 293 0 0 2 4.7 CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1 10.1038/s41467-023-40064-9
5732 206933 59 None 32 4 Human 6.7 pAC50 = 6.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 3 0 3 3.2 Cc1ccc(-c2nc3ccc(C)cn3c2CC(=O)N(C)C)cc1 10.1038/s41467-023-40064-9
CHEMBL911 206933 59 None 32 4 Human 6.7 pAC50 = 6.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 3 0 3 3.2 Cc1ccc(-c2nc3ccc(C)cn3c2CC(=O)N(C)C)cc1 10.1038/s41467-023-40064-9
6075 150106 42 None -28 20 Human 6.7 pAC50 = 6.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 310 2 0 3 4.6 CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 10.1038/s41467-023-40064-9
CHEMBL395110 150106 42 None -28 20 Human 6.7 pAC50 = 6.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 310 2 0 3 4.6 CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 10.1038/s41467-023-40064-9
4121 50833 62 None 1 2 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 359 2 2 5 0.6 CN1C(CCl)Nc2cc(Cl)c(S(N)(=O)=O)cc2S1(=O)=O 10.1038/s41467-023-40064-9
CHEMBL1577 50833 62 None 1 2 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 359 2 2 5 0.6 CN1C(CCl)Nc2cc(Cl)c(S(N)(=O)=O)cc2S1(=O)=O 10.1038/s41467-023-40064-9
5284616 161625 55 None -138 8 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 914 6 3 13 6.2 CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C 10.1038/s41467-023-40064-9
CHEMBL413 161625 55 None -138 8 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 914 6 3 13 6.2 CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C 10.1038/s41467-023-40064-9
460612 206042 66 None -1 5 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 304 8 2 3 1.9 N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O 10.1038/s41467-023-40064-9
6918992 206042 66 None -1 5 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 304 8 2 3 1.9 N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL852 206042 66 None -1 5 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 304 8 2 3 1.9 N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O 10.1038/s41467-023-40064-9
34633 5462 64 None -1 2 Human 4.7 pAC50 = 4.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 427 5 1 6 4.1 CCOC(=O)Nc1ccc2c(c1)N(C(=O)CCN1CCOCC1)c1ccccc1S2 10.1038/s41467-023-40064-9
CHEMBL1075 5462 64 None -1 2 Human 4.7 pAC50 = 4.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 427 5 1 6 4.1 CCOC(=O)Nc1ccc2c(c1)N(C(=O)CCN1CCOCC1)c1ccccc1S2 10.1038/s41467-023-40064-9
154257 178617 67 None -97 19 Human 4.7 pAC50 = 4.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 470 7 2 5 6.3 Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12 10.1038/s41467-023-40064-9
CHEMBL46740 178617 67 None -97 19 Human 4.7 pAC50 = 4.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 470 7 2 5 6.3 Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12 10.1038/s41467-023-40064-9
5282592 14474 2 None -1 2 Human 6.7 pAC50 = 6.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 290 3 1 3 2.0 C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2 10.1038/s41467-023-40064-9
CHEMBL1201235 14474 2 None -1 2 Human 6.7 pAC50 = 6.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 290 3 1 3 2.0 C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2 10.1038/s41467-023-40064-9
124087 1388 114 None -12 27 Human 5.7 pAC50 = 5.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 10.1038/s41467-023-40064-9
7157 1388 114 None -12 27 Human 5.7 pAC50 = 5.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 10.1038/s41467-023-40064-9
814 1388 114 None -12 27 Human 5.7 pAC50 = 5.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 10.1038/s41467-023-40064-9
CHEMBL1172 1388 114 None -12 27 Human 5.7 pAC50 = 5.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 10.1038/s41467-023-40064-9
DB00967 1388 114 None -12 27 Human 5.7 pAC50 = 5.7 Functional
Compound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assayCompound was evaluated for inhibition of human CHRM1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 10.1038/s41467-023-40064-9
2580 78393 18 None -1047 10 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 446 6 1 4 4.1 NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1 10.1038/s41467-023-40064-9
CHEMBL2110775 78393 18 None -1047 10 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 446 6 1 4 4.1 NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1 10.1038/s41467-023-40064-9
23497 22890 38 None -4 3 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 211 3 3 5 0.1 COC(=O)[C@@H](N)Cc1ccc(O)c(O)c1 10.1038/s41467-023-40064-9
CHEMBL1328898 22890 38 None -4 3 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 211 3 3 5 0.1 COC(=O)[C@@H](N)Cc1ccc(O)c(O)c1 10.1038/s41467-023-40064-9
1599 2339 50 None -12022 21 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
3955 2339 50 None -12022 21 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
7215 2339 50 None -12022 21 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL841 2339 50 None -12022 21 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
DB00836 2339 50 None -12022 21 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human CHRM1 in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
10311 57498 27 None -11 2 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 398 4 4 9 0.3 Nc1nc(N)nc(Nc2ccc([As]3SCC(CO)S3)cc2)n1 10.1038/s41467-023-40064-9
CHEMBL166 57498 27 None -11 2 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
ChEMBL 398 4 4 9 0.3 Nc1nc(N)nc(Nc2ccc([As]3SCC(CO)S3)cc2)n1 10.1038/s41467-023-40064-9
25295