Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL100147 acm1_human Human No 9.7 EC50 = 0.2 Funct
Effective concentration required for stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptorEffective concentration required for stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptor
341 4 0 5 3.7 C1CC2CN(C1)CC2C3=NSN=C3SCC#CC4=CC=CC=C4
CHEMBL1223754 acm1_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
404 5 1 4 4.1 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=C(C(=C4)C)F)NC3=O
CHEMBL1223804 acm1_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
371 4 0 3 3.6 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C(=O)CC4=C3C=C(C=C4)C
CHEMBL1223754 acm1_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
404 5 1 4 4.1 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=C(C(=C4)C)F)NC3=O
CHEMBL1223804 acm1_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
371 4 0 3 3.6 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C(=O)CC4=C3C=C(C=C4)C
CHEMBL98255 acm1_human Human No 9.3 EC50 = 0.5 Funct
Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptorStimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptor
325 4 0 5 3.2 C1CC2CN(C1)CC2C3=NSN=C3OCC#CC4=CC=CC=C4
CHEMBL1223803 acm1_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
385 5 0 3 4.2 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C(=O)CC4=C3C=C(C=C4)C
CHEMBL1223803 acm1_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
385 5 0 3 4.2 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C(=O)CC4=C3C=C(C=C4)C
CHEMBL3360954 acm1_human Human No 9.2 EC50 = 0.6 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
373 3 1 5 2.8 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C=C4C(=NNC4=O)C5=CC=CC=C53)F
CHEMBL3360954 acm1_human Human No 9.2 EC50 = 0.6 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
373 3 1 5 2.8 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C=C4C(=NNC4=O)C5=CC=CC=C53)F
CHEMBL490797 acm1_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
423 4 1 4 3.9 CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C=CC(=C5)F)NC4=O
CHEMBL490797 acm1_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
423 4 1 4 3.9 CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C=CC(=C5)F)NC4=O
CHEMBL1083925 acm1_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
361 4 2 3 4.3 CC1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL1083925 acm1_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
361 4 2 3 4.3 CC1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL522451 acm1_human Human No 9.1 EC50 = 0.9 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
423 4 1 4 3.9 CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C=C(C=C5)F)NC4=O
CHEMBL522451 acm1_human Human No 9.1 EC50 = 0.9 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
423 4 1 4 3.9 CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C=C(C=C5)F)NC4=O
CHEMBL327269 acm1_human Human No 9.0 EC50 = 1.0 Funct
Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptorStimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptor
311 4 0 5 2.8 C1CN2CC1C(C2)C3=NSN=C3OCC#CC4=CC=CC=C4
CHEMBL1084850 acm1_human Human No 9.0 EC50 = 1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
330 5 2 2 4.4 C1CNCCC1CCC(C2=CC=CC=C2C3=CC(=CC=C3)Cl)O
CHEMBL1223860 acm1_human Human No 9.0 EC50 = 1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
390 4 0 5 4.1 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=C(C(=C4)C)F)OC3=O
CHEMBL1084850 acm1_human Human No 9.0 EC50 = 1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
330 5 2 2 4.4 C1CNCCC1CCC(C2=CC=CC=C2C3=CC(=CC=C3)Cl)O
CHEMBL1223860 acm1_human Human No 9.0 EC50 = 1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
390 4 0 5 4.1 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=C(C(=C4)C)F)OC3=O
CHEMBL340435 acm1_human Human No 9.0 EC50 = 1 Funct
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
285 5 0 6 3.0 CCCSC1=NSN=C1OC2CN3CCCC2C3
CHEMBL316625 acm1_human Human No 9.0 EC50 = 1 Funct
Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptorStimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptor
341 4 0 5 3.7 C1CC2CN(C1)CC2C3=NSN=C3SCC#CC4=CC=CC=C4
CHEMBL489576 acm1_human Human No 9.0 EC50 = 1.0 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
477 4 1 7 4.4 C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)F)NC3=O)CC5=CC=CC=C5C(F)(F)F
CHEMBL489576 acm1_human Human No 9.0 EC50 = 1.0 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
477 4 1 7 4.4 C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)F)NC3=O)CC5=CC=CC=C5C(F)(F)F
CHEMBL490598 acm1_human Human No 9.0 EC50 = 1.1 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
423 4 1 4 3.9 CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C(=CC=C5)F)NC4=O
CHEMBL490598 acm1_human Human No 9.0 EC50 = 1.1 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
423 4 1 4 3.9 CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C(=CC=C5)F)NC4=O
CHEMBL3360955 acm1_human Human No 8.9 EC50 = 1.2 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
341 3 1 4 2.7 C1=CC=C2C(=C1)C3=NNC(=O)C3=CN2CC4=CC=C(C=C4)N5C=CC=N5
CHEMBL3360955 acm1_human Human No 8.9 EC50 = 1.2 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
341 3 1 4 2.7 C1=CC=C2C(=C1)C3=NNC(=O)C3=CN2CC4=CC=C(C=C4)N5C=CC=N5
CHEMBL1223861 acm1_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
390 4 0 5 4.1 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C(=CC(=C4)C)F)OC3=O
CHEMBL1223861 acm1_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
390 4 0 5 4.1 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C(=CC(=C4)C)F)OC3=O
CHEMBL521914 acm1_human Human No 8.8 EC50 = 1.7 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
477 4 1 7 4.4 C1CN(CCC1N2CCC(CC2)N3C4=C(C(=CC=C4)F)NC3=O)CC5=CC=CC=C5C(F)(F)F
CHEMBL521914 acm1_human Human No 8.8 EC50 = 1.7 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
477 4 1 7 4.4 C1CN(CCC1N2CCC(CC2)N3C4=C(C(=CC=C4)F)NC3=O)CC5=CC=CC=C5C(F)(F)F
CHEMBL594432 acm1_human Human No 8.8 EC50 = 1.8 Funct
Agonist activity at human muscarinic M1 acetylcholine receptor expressed CHO cells assessed as intracellular calcium mobilization after 1 hr by Fluo-4-AM based fluorescence assayAgonist activity at human muscarinic M1 acetylcholine receptor expressed CHO cells assessed as intracellular calcium mobilization after 1 hr by Fluo-4-AM based fluorescence assay
345 4 1 7 3.6 COC1=CC=C(C=C1)CN2C=C(C(=O)C3=C(C=CC(=C32)F)F)C(=O)O
CHEMBL126846 acm1_human Human No 8.7 EC50 = 1.9 Funct
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
271 5 0 6 2.7 CCCSC1=NSN=C1OC2CN3CCC2C3
CHEMBL335542 acm1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human M1 receptor E170K mutant expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor E170K mutant expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
553 16 0 13 1.2 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOC3=NSN=C3C4=CCCN(C4)C
CHEMBL1083108 acm1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
347 4 2 3 3.9 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=C(C=CC(=C3)Cl)F
CHEMBL1082365 acm1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
379 4 2 4 4.3 CC1CNCCC1(CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl)F
CHEMBL1223941 acm1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
414 6 0 6 2.9 CC1(CCC(CC1)OCCOC)N2CCC(CC2)N3C4=C(C=CC(=C4)C#N)OC3=O
CHEMBL1242925 acm1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
381 6 1 6 2.0 CCC(=O)NC1CCN(CC1)CCCN2C(=O)COC3=CC(=C(C=C32)F)F
CHEMBL115581 acm1_human Human Yes 8.0 EC50 = 10 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
237 2 0 2 2.1 C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=O)C2=O
CHEMBL3360956 acm1_human Human No 8.0 EC50 = 10 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
303 3 0 3 2.4 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)N4C=CC=N4
CHEMBL335542 acm1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human M1 receptor E170K mutant expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor E170K mutant expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
553 16 0 13 1.2 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOC3=NSN=C3C4=CCCN(C4)C
CHEMBL1083108 acm1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
347 4 2 3 3.9 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=C(C=CC(=C3)Cl)F
CHEMBL1082365 acm1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
379 4 2 4 4.3 CC1CNCCC1(CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl)F
CHEMBL1223941 acm1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
414 6 0 6 2.9 CC1(CCC(CC1)OCCOC)N2CCC(CC2)N3C4=C(C=CC(=C4)C#N)OC3=O
CHEMBL1242925 acm1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
381 6 1 6 2.0 CCC(=O)NC1CCN(CC1)CCCN2C(=O)COC3=CC(=C(C=C32)F)F
CHEMBL115581 acm1_human Human Yes 8.0 EC50 = 10 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
237 2 0 2 2.1 C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=O)C2=O
CHEMBL3360956 acm1_human Human No 8.0 EC50 = 10 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
303 3 0 3 2.4 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)N4C=CC=N4
CHEMBL60833 acm1_human Human No 8.0 EC50 = 10.5 Funct
Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.
344 4 0 5 3.2 C1C2C3C2(CN1C3)C4=NSN=C4OCC#CC5=CC(=CC=C5)Cl
CHEMBL3354074 acm1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assay
387 11 1 3 4.6 C1CN(CCC1CCCCCCCO)CCCN2C(=O)CCC3=CC=CC=C32
CHEMBL1083277 acm1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
363 4 2 2 4.4 C1CNCCC1CNC(=O)C2=C(C=CC(=C2)Cl)C3=CC(=CC=C3)Cl
CHEMBL1082316 acm1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
363 4 2 2 4.4 C1CNCCC1CNC(=O)C2=C(C=C(C=C2)Cl)C3=CC(=CC=C3)Cl
CHEMBL1243138 acm1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
424 7 1 4 3.5 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C(=O)CSC4=CC=CC=C43
CHEMBL3354074 acm1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assay
387 11 1 3 4.6 C1CN(CCC1CCCCCCCO)CCCN2C(=O)CCC3=CC=CC=C32
CHEMBL1083277 acm1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
363 4 2 2 4.4 C1CNCCC1CNC(=O)C2=C(C=CC(=C2)Cl)C3=CC(=CC=C3)Cl
CHEMBL1082316 acm1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
363 4 2 2 4.4 C1CNCCC1CNC(=O)C2=C(C=C(C=C2)Cl)C3=CC(=CC=C3)Cl
CHEMBL1243138 acm1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
424 7 1 4 3.5 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C(=O)CSC4=CC=CC=C43
CHEMBL373888 acm1_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
399 10 0 11 1.5 CN1CCC=C(C1)C2=NSN=C2OCCOCCOC3=NSN=C3OC
CHEMBL2022948 acm1_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
351 7 2 5 2.2 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CS3
CHEMBL3084452 acm1_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
351 7 2 4 2.3 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3CCCCC3
CHEMBL1084851 acm1_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
312 4 1 1 5.4 C1CNCCC1CC=CC2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL1084572 acm1_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
347 4 2 3 3.9 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=C(C(=CC=C3)Cl)F
CHEMBL1083718 acm1_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
343 4 2 2 4.1 CC1=CC(=C(C=C1)C2=CC(=CC=C2)Cl)C(=O)NCC3CCNCC3
CHEMBL3360928 acm1_human Human Yes 6.0 EC50 = 1000 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
383 4 0 4 4.5 C1=CC=C(C=C1)CN2C=C3C(=NN(C3=O)CC4=CC=CC=C4F)C5=CC=CC=C52
CHEMBL373888 acm1_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
399 10 0 11 1.5 CN1CCC=C(C1)C2=NSN=C2OCCOCCOC3=NSN=C3OC
CHEMBL2022948 acm1_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
351 7 2 5 2.2 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CS3
CHEMBL3084452 acm1_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
351 7 2 4 2.3 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3CCCCC3
CHEMBL1084851 acm1_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
312 4 1 1 5.4 C1CNCCC1CC=CC2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL1084572 acm1_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
347 4 2 3 3.9 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=C(C(=CC=C3)Cl)F
CHEMBL1083718 acm1_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
343 4 2 2 4.1 CC1=CC(=C(C=C1)C2=CC(=CC=C2)Cl)C(=O)NCC3CCNCC3
CHEMBL3360928 acm1_human Human Yes 6.0 EC50 = 1000 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
383 4 0 4 4.5 C1=CC=C(C=C1)CN2C=C3C(=NN(C3=O)CC4=CC=CC=C4F)C5=CC=CC=C52
CHEMBL314737 acm1_human Human Yes 4.0 EC50 = 100000 Funct
Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholine receptor M1Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholine receptor M1
180 1 1 5 0.1 C1CN2CC1C(C2)C3=NC(=NO3)N
CHEMBL3745973 acm1_human Human No 7.0 EC50 = 101 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
415 5 2 4 2.5 C1CCC(C(C1)NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)N5C=CC=N5)O
CHEMBL3745973 acm1_human Human No 7.0 EC50 = 101 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
415 5 2 4 2.5 C1CCC(C(C1)NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)N5C=CC=N5)O
CHEMBL3360928 acm1_human Human Yes 6.0 EC50 = 1010 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
383 4 0 4 4.5 C1=CC=C(C=C1)CN2C=C3C(=NN(C3=O)CC4=CC=CC=C4F)C5=CC=CC=C52
CHEMBL341242 acm1_human Human No 7.0 EC50 = 102 Funct
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
283 6 0 6 2.8 CCCCOC1=NSN=C1OC2CN3CCC2CC3
CHEMBL523657 acm1_human Human No 6.0 EC50 = 1030 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
439 4 1 3 4.4 CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C=C(C=C5)Cl)NC4=O
CHEMBL1085686 acm1_rat Rat No 6.0 EC50 = 1030 Funct
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]
371 3 0 6 2.6 CN1C=C(C=N1)C2=CC(=C(C(=C2)F)CN3C4=C(C=CC=C4F)C(=O)C3=O)F
CHEMBL523657 acm1_human Human No 6.0 EC50 = 1030 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
439 4 1 3 4.4 CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C=C(C=C5)Cl)NC4=O
CHEMBL1085686 acm1_rat Rat No 6.0 EC50 = 1030 Funct
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]
371 3 0 6 2.6 CN1C=C(C=N1)C2=CC(=C(C(=C2)F)CN3C4=C(C=CC=C4F)C(=O)C3=O)F
CHEMBL3618439 acm1_human Human No 7.0 EC50 = 105 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
494 6 3 4 3.8 CC(=NC1=CC=C(C=C1)OC)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3618439 acm1_human Human No 7.0 EC50 = 105 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
494 6 3 4 3.8 CC(=NC1=CC=C(C=C1)OC)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3745973 acm1_human Human No 7.0 EC50 = 106 Funct
Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as increase in ACh-induced intracellular calcium level preincubated for 10 mins followed by ACh addition measured every 2 secs for 80 secs by Fluo-4 dye-based FLIPR assayPositive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as increase in ACh-induced intracellular calcium level preincubated for 10 mins followed by ACh addition measured every 2 secs for 80 secs by Fluo-4 dye-based FLIPR assay
415 5 2 4 2.5 C1CCC(C(C1)NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)N5C=CC=N5)O
CHEMBL60374 acm1_human Human No 7.0 EC50 = 107 Funct
Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.
360 4 0 5 3.7 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC=C(C=C5)Cl
CHEMBL3608419 acm1_human Human No 8.0 EC50 = 11.1 Funct
Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
431 5 2 5 1.3 CN1C=C(C=N1)C2=CC=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5COCCC5O
CHEMBL3608419 acm1_human Human No 8.0 EC50 = 11.1 Funct
Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
431 5 2 5 1.3 CN1C=C(C=N1)C2=CC=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5COCCC5O
CHEMBL2059306 acm1_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
405 5 1 3 3.8 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL2059324 acm1_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
424 5 1 5 2.6 C1CN(CCC1N2C3=C(C(=CC=C3)F)NC2=O)CCCN4C(=O)COC5=CC=CC=C54
CHEMBL2024407 acm1_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
345 7 2 4 2.2 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3
CHEMBL2024408 acm1_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
345 7 2 4 2.2 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3
CHEMBL1243267 acm1_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
357 6 1 4 1.8 C1CC1C(=O)NC2CCN(CC2)CCCN3C(=O)COC4=CC=CC=C43
CHEMBL1916224 acm1_rat Rat No 7.0 EC50 = 110 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
374 5 1 4 3.0 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC=CC=C3C
CHEMBL2059306 acm1_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
405 5 1 3 3.8 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL2059324 acm1_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
424 5 1 5 2.6 C1CN(CCC1N2C3=C(C(=CC=C3)F)NC2=O)CCCN4C(=O)COC5=CC=CC=C54
CHEMBL1243267 acm1_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
357 6 1 4 1.8 C1CC1C(=O)NC2CCN(CC2)CCCN3C(=O)COC4=CC=CC=C43
CHEMBL1916224 acm1_rat Rat No 7.0 EC50 = 110 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
374 5 1 4 3.0 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC=CC=C3C
CHEMBL171721 acm1_rat Rat No 7.0 EC50 = 110 Funct
Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion (mediated by muscarinic acetylcholine receptor M1)Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion (mediated by muscarinic acetylcholine receptor M1)
193 1 0 4 1.4 CC1=NOC(=N1)C2(CN3CCC2C3)C
CHEMBL1916226 acm1_rat Rat No 7.0 EC50 = 110 Funct
Partial agonist activity at rat muscarinic M1 receptor expressed in CHO cells calcium responsePartial agonist activity at rat muscarinic M1 receptor expressed in CHO cells calcium response
359 5 1 4 2.6 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC=CC=C3
CHEMBL291351 acm1_human Human No 7.0 EC50 = 110 Funct
Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptorStimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptor
311 4 0 5 2.8 CN1CCC=C(C1)C2=NSN=C2OCC#CC3=CC=CC=C3
CHEMBL60777 acm1_human Human No 7.0 EC50 = 110 Funct
Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.
362 4 0 6 3.3 C1C2C3C2(CN1C3)C4=NSN=C4OCC#CC5=CC(=CC(=C5)Cl)F
CHEMBL291351 acm1_human Human No 7.0 EC50 = 110.9 Funct
Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.
311 4 0 5 2.8 CN1CCC=C(C1)C2=NSN=C2OCC#CC3=CC=CC=C3
CHEMBL2024418 acm1_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
359 7 2 4 2.6 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3C
CHEMBL1243139 acm1_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
393 7 1 4 3.2 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C4=CC=CC=C4OC3=O
CHEMBL514689 acm1_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
470 4 1 5 3.9 C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5[N+](=O)[O-]
CHEMBL1085686 acm1_human Human No 6.0 EC50 = 1100 Funct
Potentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPotentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
371 3 0 6 2.6 CN1C=C(C=N1)C2=CC(=C(C(=C2)F)CN3C4=C(C=CC=C4F)C(=O)C3=O)F
CHEMBL2024418 acm1_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
359 7 2 4 2.6 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3C
CHEMBL1243139 acm1_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
393 7 1 4 3.2 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C4=CC=CC=C4OC3=O
CHEMBL514689 acm1_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
470 4 1 5 3.9 C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5[N+](=O)[O-]
CHEMBL1085686 acm1_human Human No 6.0 EC50 = 1100 Funct
Potentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPotentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
371 3 0 6 2.6 CN1C=C(C=N1)C2=CC(=C(C(=C2)F)CN3C4=C(C=CC=C4F)C(=O)C3=O)F
CHEMBL521388 acm1_human Human No 5.0 EC50 = 11100 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
507 3 1 6 4.6 C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)C4CCN(CC4)C(=O)C5=CC=CC=C5C(F)(F)F
CHEMBL521388 acm1_human Human No 5.0 EC50 = 11100 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
507 3 1 6 4.6 C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)C4CCN(CC4)C(=O)C5=CC=CC=C5C(F)(F)F
CHEMBL3746514 acm1_human Human No 7.0 EC50 = 112 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
402 6 1 4 1.4 CN(C)C(=O)CNC(=O)C1=CN(C2=C1N=CC=C2)CC3=CC=C(C=C3)N4C=CC=N4
CHEMBL3746514 acm1_human Human No 7.0 EC50 = 112 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
402 6 1 4 1.4 CN(C)C(=O)CNC(=O)C1=CN(C2=C1N=CC=C2)CC3=CC=C(C=C3)N4C=CC=N4
CHEMBL3354073 acm1_human Human No 7.0 EC50 = 112.2 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assay
359 9 1 3 3.5 C1CN(CCC1CCCCCO)CCCN2C(=O)CCC3=CC=CC=C32
CHEMBL3354073 acm1_human Human No 7.0 EC50 = 112.2 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assay
359 9 1 3 3.5 C1CN(CCC1CCCCCO)CCCN2C(=O)CCC3=CC=CC=C32
CHEMBL3360950 acm1_human Human No 5.9 EC50 = 1148.2 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
460 5 0 4 5.1 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC=C(C=C5)N6C=CC=N6)C
CHEMBL3360950 acm1_human Human No 5.9 EC50 = 1148.2 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
460 5 0 4 5.1 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC=C(C=C5)N6C=CC=N6)C
CHEMBL3360950 acm1_human Human No 5.9 EC50 = 1150 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
460 5 0 4 5.1 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC=C(C=C5)N6C=CC=N6)C
CHEMBL3618437 acm1_human Human No 6.9 EC50 = 118 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
496 5 2 4 4.1 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)Br)O)C=C1)N(C)C4=CC=C(C=C4)F
CHEMBL3618437 acm1_human Human No 6.9 EC50 = 118 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
496 5 2 4 4.1 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)Br)O)C=C1)N(C)C4=CC=C(C=C4)F
CHEMBL2059307 acm1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
406 5 1 4 2.7 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCN4C(=O)CCC5=C4C=CC=N5
CHEMBL2059307 acm1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
406 5 1 4 2.7 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCN4C(=O)CCC5=C4C=CC=N5
CHEMBL2336059 acm1_human Human No 7.9 EC50 = 12 Funct
Partial agonist activity at human M1 receptor in CHO cells assessed as calcium mobilization after 60 mins by FLIPR assayPartial agonist activity at human M1 receptor in CHO cells assessed as calcium mobilization after 60 mins by FLIPR assay
398 5 0 4 2.8 CCOC(=O)N1C2CCC1CC(C2)CN3CCC(C3)N4C(=O)CC5=CC=CC=C54
CHEMBL1083723 acm1_human Human No 7.9 EC50 = 12.6 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
343 4 2 2 4.1 CC1=C(C=C(C=C1)C2=CC=CC=C2C(=O)NCC3CCNCC3)Cl
CHEMBL1223864 acm1_human Human No 7.9 EC50 = 12.6 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
437 5 0 6 2.9 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)C)OC3=O
CHEMBL1083723 acm1_human Human No 7.9 EC50 = 12.6 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
343 4 2 2 4.1 CC1=C(C=C(C=C1)C2=CC=CC=C2C(=O)NCC3CCNCC3)Cl
CHEMBL1223864 acm1_human Human No 7.9 EC50 = 12.6 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
437 5 0 6 2.9 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)C)OC3=O
CHEMBL1243109 acm1_human Human No 6.9 EC50 = 120 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
436 8 1 4 3.1 COC1=CC2=C(CCC(=O)N2CCCN3CCC(CC3)NC(=O)CC4=CC=CC=C4)C=C1
CHEMBL478034 acm1_human Human No 6.9 EC50 = 120 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
436 4 1 5 3.3 C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5[N+](=O)[O-]
CHEMBL1243109 acm1_human Human No 6.9 EC50 = 120 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
436 8 1 4 3.1 COC1=CC2=C(CCC(=O)N2CCCN3CCC(CC3)NC(=O)CC4=CC=CC=C4)C=C1
CHEMBL478034 acm1_human Human No 6.9 EC50 = 120 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
436 4 1 5 3.3 C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5[N+](=O)[O-]
CHEMBL336933 acm1_human Human No 6.9 EC50 = 120 Funct
Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.
551 14 0 10 5.7 CN1CCC=C(C1)C2=NSN=C2SCCCCCCCCCSC3=NSN=C3C4=CCCN(C4)C
CHEMBL2059314 acm1_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
407 5 1 5 1.5 C1CN(CCC1N2C3=C(C=CN=C3)NC2=O)CCCN4C(=O)COC5=CC=CC=C54
CHEMBL2024404 acm1_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
386 5 1 4 3.2 CCOC(=O)N1C2CCC1CC(C2)N3CCC(C3)NC(=O)C4=CC=CC=C4C
CHEMBL2024403 acm1_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
371 5 1 4 2.9 CCOC(=O)N1C2CCC1CC(C2)N3CCC(C3)NC(=O)C4=CC=CC=C4
CHEMBL2024407 acm1_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human muscarinic M1 receptor by calcium mobilization assayAgonist activity at human muscarinic M1 receptor by calcium mobilization assay
345 7 2 4 2.2 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3
CHEMBL2024408 acm1_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human muscarinic M1 receptor by calcium mobilization assayAgonist activity at human muscarinic M1 receptor by calcium mobilization assay
345 7 2 4 2.2 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3
CHEMBL1084940 acm1_human Human No 5.9 EC50 = 1200 Funct
Potentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPotentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
371 3 0 6 2.6 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=C(C=CC(=C4C(=O)C3=O)F)F)F
CHEMBL2059314 acm1_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
407 5 1 5 1.5 C1CN(CCC1N2C3=C(C=CN=C3)NC2=O)CCCN4C(=O)COC5=CC=CC=C54
CHEMBL2024404 acm1_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
386 5 1 4 3.2 CCOC(=O)N1C2CCC1CC(C2)N3CCC(C3)NC(=O)C4=CC=CC=C4C
CHEMBL2024403 acm1_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
371 5 1 4 2.9 CCOC(=O)N1C2CCC1CC(C2)N3CCC(C3)NC(=O)C4=CC=CC=C4
CHEMBL2024407 acm1_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human muscarinic M1 receptor by calcium mobilization assayAgonist activity at human muscarinic M1 receptor by calcium mobilization assay
345 7 2 4 2.2 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3
CHEMBL2024408 acm1_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human muscarinic M1 receptor by calcium mobilization assayAgonist activity at human muscarinic M1 receptor by calcium mobilization assay
345 7 2 4 2.2 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3
CHEMBL1084940 acm1_human Human No 5.9 EC50 = 1200 Funct
Potentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPotentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
371 3 0 6 2.6 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=C(C=CC(=C4C(=O)C3=O)F)F)F
CHEMBL59862 acm1_human Human No 5.9 EC50 = 1200 Funct
Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.
377 4 0 4 5.4 C1C2CC3C1C3(C2)C4=NSN=C4OCC#CC5=CC(=CC(=C5)Cl)Cl
CHEMBL12378 acm1_mouse Mouse Yes 4.9 EC50 = 12000 Funct
Tested against Muscarinic acetylcholine receptor M1 expressed in A9 L cell lineTested against Muscarinic acetylcholine receptor M1 expressed in A9 L cell line
179 1 0 4 0.8 CC1=NOC(=N1)C2=CCCN(C2)C
CHEMBL1084940 acm1_rat Rat No 5.9 EC50 = 1230 Funct
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]
371 3 0 6 2.6 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=C(C=CC(=C4C(=O)C3=O)F)F)F
CHEMBL1084940 acm1_rat Rat No 5.9 EC50 = 1230 Funct
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]
371 3 0 6 2.6 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=C(C=CC(=C4C(=O)C3=O)F)F)F
CHEMBL1242979 acm1_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
502 9 1 7 3.3 COC1=C(C=C(C=C1)CC(=O)NC2CCN(CC2)CCCN3C(=O)CCC4=CC(=C(C=C43)F)F)OC
CHEMBL1242979 acm1_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
502 9 1 7 3.3 COC1=C(C=C(C=C1)CC(=O)NC2CCN(CC2)CCCN3C(=O)CCC4=CC(=C(C=C43)F)F)OC
CHEMBL3608419 acm1_rat Rat No 7.9 EC50 = 13.8 Funct
Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
431 5 2 5 1.3 CN1C=C(C=N1)C2=CC=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5COCCC5O
CHEMBL3608419 acm1_rat Rat No 7.9 EC50 = 13.8 Funct
Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
431 5 2 5 1.3 CN1C=C(C=N1)C2=CC=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5COCCC5O
CHEMBL1243010 acm1_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
438 8 1 5 2.9 COC1=CC=CC(=C1)CC(=O)NC2CCN(CC2)CCCN3C(=O)COC4=CC=CC=C43
CHEMBL1916226 acm1_rat Rat No 6.9 EC50 = 130 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
359 5 1 4 2.6 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC=CC=C3
CHEMBL1243010 acm1_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
438 8 1 5 2.9 COC1=CC=CC(=C1)CC(=O)NC2CCN(CC2)CCCN3C(=O)COC4=CC=CC=C43
CHEMBL1916226 acm1_rat Rat No 6.9 EC50 = 130 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
359 5 1 4 2.6 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC=CC=C3
CHEMBL1916224 acm1_human Human No 5.9 EC50 = 1300 Funct
Agonist activity at human recombinant muscarinic M1 receptor by HTS cell based assayAgonist activity at human recombinant muscarinic M1 receptor by HTS cell based assay
374 5 1 4 3.0 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC=CC=C3C
CHEMBL1916232 acm1_rat Rat No 5.9 EC50 = 1300 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
365 5 1 5 2.6 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC=CS3
CHEMBL1916224 acm1_rat Rat No 5.9 EC50 = 1300 Funct
Agonist activity at rat recombinant muscarinic M1 receptor by HTS cell based assayAgonist activity at rat recombinant muscarinic M1 receptor by HTS cell based assay
374 5 1 4 3.0 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC=CC=C3C
CHEMBL1916224 acm1_human Human No 5.9 EC50 = 1300 Funct
Agonist activity at human recombinant muscarinic M1 receptor by HTS cell based assayAgonist activity at human recombinant muscarinic M1 receptor by HTS cell based assay
374 5 1 4 3.0 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC=CC=C3C
CHEMBL1916232 acm1_rat Rat No 5.9 EC50 = 1300 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
365 5 1 5 2.6 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC=CS3
CHEMBL1916224 acm1_rat Rat No 5.9 EC50 = 1300 Funct
Agonist activity at rat recombinant muscarinic M1 receptor by HTS cell based assayAgonist activity at rat recombinant muscarinic M1 receptor by HTS cell based assay
374 5 1 4 3.0 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC=CC=C3C
CHEMBL2313530 acm1_human Human No 5.9 EC50 = 1300 Funct
Positive allosteric modulator activity at human muscarinic M1 receptor by calcium mobilization assayPositive allosteric modulator activity at human muscarinic M1 receptor by calcium mobilization assay
336 3 1 4 1.7 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=CC=CC=C4C(C3=O)N)F
CHEMBL139603 acm1_human Human No 4.9 EC50 = 13000 Funct
Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.
593 17 0 10 7.4 CN1CCC=C(C1)C2=NSN=C2SCCCCCCCCCCCCSC3=NSN=C3C4=CCCN(C4)C
CHEMBL125732 acm1_human Human Yes 6.9 EC50 = 135.8 Funct
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
313 7 0 6 3.9 CCCCCSC1=NSN=C1OC2CN3CCC2CC3
CHEMBL1357815 acm1_rat Rat Yes 5.9 EC50 = 1380 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
506 6 1 6 4.3 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=C(C=CC(=C4)Br)F
CHEMBL1357815 acm1_rat Rat Yes 5.9 EC50 = 1380 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
506 6 1 6 4.3 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=C(C=CC(=C4)Br)F
CHEMBL3633184 acm1_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human muscarinic M1 acetylcholine receptor expressed in CHO cells assessed as calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 acetylcholine receptor expressed in CHO cells assessed as calcium mobilization by FLIPR assay
413 5 1 4 2.6 CCOC(=O)N1C2CCC1CC(C2)CN3CCC(C3)N4CC5=CC=CC=C5NC4=O
CHEMBL3633184 acm1_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human muscarinic M1 acetylcholine receptor expressed in CHO cells assessed as calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 acetylcholine receptor expressed in CHO cells assessed as calcium mobilization by FLIPR assay
413 5 1 4 2.6 CCOC(=O)N1C2CCC1CC(C2)CN3CCC(C3)N4CC5=CC=CC=C5NC4=O
CHEMBL1916227 acm1_rat Rat No 6.9 EC50 = 140 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
377 5 1 5 2.7 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC(=CC=C3)F
CHEMBL1916227 acm1_rat Rat No 6.9 EC50 = 140 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
377 5 1 5 2.7 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC(=CC=C3)F
CHEMBL69306 acm1_human Human No 6.9 EC50 = 140 Funct
In Vitro evaluation activity at the cloned Human Muscarinic acetylcholine receptor M1 determined by receptor selection and amplification technology (R-SAT)In Vitro evaluation activity at the cloned Human Muscarinic acetylcholine receptor M1 determined by receptor selection and amplification technology (R-SAT)
192 2 1 4 0.4 C#CCOC1=NOC2=C1CNCCC2
CHEMBL487762 acm1_human Human No 5.9 EC50 = 1400 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
441 4 1 5 3.4 C1CN(CCC1N2C3=CC=CC=C3NC2=O)C4CCN(CC4)S(=O)(=O)C5=CC=CC=C5
CHEMBL487762 acm1_human Human No 5.9 EC50 = 1400 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
441 4 1 5 3.4 C1CN(CCC1N2C3=CC=CC=C3NC2=O)C4CCN(CC4)S(=O)(=O)C5=CC=CC=C5
CHEMBL3360939 acm1_human Human No 5.9 EC50 = 1412.5 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
411 4 0 4 5.2 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC(=CC=C5)F)C
CHEMBL3360939 acm1_human Human No 5.9 EC50 = 1412.5 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
411 4 0 4 5.2 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC(=CC=C5)F)C
CHEMBL3360939 acm1_human Human No 5.9 EC50 = 1420 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
411 4 0 4 5.2 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC(=CC=C5)F)C
CHEMBL1357815 acm1_rat Rat Yes 5.9 EC50 = 1424 Funct
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]
506 6 1 6 4.3 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=C(C=CC(=C4)Br)F
CHEMBL1357815 acm1_rat Rat Yes 5.9 EC50 = 1424 Funct
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]
506 6 1 6 4.3 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=C(C=CC(=C4)Br)F
CHEMBL1242951 acm1_human Human No 7.8 EC50 = 15 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
442 7 1 5 3.3 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C(=O)CCC4=CC(=C(C=C43)F)F
CHEMBL1242951 acm1_human Human No 7.8 EC50 = 15 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
442 7 1 5 3.3 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C(=O)CCC4=CC(=C(C=C43)F)F
CHEMBL3608421 acm1_human Human No 7.8 EC50 = 15.5 Funct
Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
449 5 2 6 1.4 CN1C=C(C=N1)C2=C(C=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5COCCC5O)F
CHEMBL3608421 acm1_human Human No 7.8 EC50 = 15.5 Funct
Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
449 5 2 6 1.4 CN1C=C(C=N1)C2=C(C=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5COCCC5O)F
CHEMBL99521 acm1_human Human Yes 7.8 EC50 = 15.7 Funct
Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptorStimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptor
325 4 0 5 3.2 C1CN2CCC1C(C2)C3=NSN=C3OCC#CC4=CC=CC=C4
CHEMBL1082680 acm1_human Human No 7.8 EC50 = 15.9 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
347 4 2 3 3.9 C1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL1082680 acm1_human Human No 7.8 EC50 = 15.9 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
347 4 2 3 3.9 C1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL1243011 acm1_human Human No 6.8 EC50 = 150 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
424 7 1 4 3.2 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C(=O)CCC4=C3C=CC=C4F
CHEMBL1243011 acm1_human Human No 6.8 EC50 = 150 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
424 7 1 4 3.2 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C(=O)CCC4=C3C=CC=C4F
CHEMBL2024426 acm1_human Human No 5.8 EC50 = 1500 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
351 7 2 4 2.6 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3CCCCC3
CHEMBL518747 acm1_human Human No 5.8 EC50 = 1500 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
493 4 1 6 4.9 C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5C(F)(F)F
CHEMBL2024426 acm1_human Human No 5.8 EC50 = 1500 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
351 7 2 4 2.6 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3CCCCC3
CHEMBL518747 acm1_human Human No 5.8 EC50 = 1500 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
493 4 1 6 4.9 C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5C(F)(F)F
CHEMBL143466 acm1_human Human No 5.8 EC50 = 1500 Funct
Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.
579 16 0 10 6.8 CN1CCC=C(C1)C2=NSN=C2SCCCCCCCCCCCSC3=NSN=C3C4=CCCN(C4)C
CHEMBL3618447 acm1_human Human No 6.8 EC50 = 154 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
510 6 2 4 4.1 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)Br)O)C=C1)N(C)CC4=CC=C(C=C4)F
CHEMBL3618447 acm1_human Human No 6.8 EC50 = 154 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
510 6 2 4 4.1 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)Br)O)C=C1)N(C)CC4=CC=C(C=C4)F
CHEMBL3360946 acm1_human Human No 5.8 EC50 = 1548.8 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
394 4 0 4 4.1 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC=NC=C5)C
CHEMBL3360946 acm1_human Human No 5.8 EC50 = 1548.8 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
394 4 0 4 4.1 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC=NC=C5)C
CHEMBL3360946 acm1_human Human No 5.8 EC50 = 1550 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
394 4 0 4 4.1 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC=NC=C5)C
CHEMBL1083927 acm1_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
393 4 2 3 4.1 CC1CNCC=C1CNC(=O)C2=C(C=CC(=C2F)Cl)C3=CC(=CC=C3)Cl
CHEMBL1083003 acm1_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
365 4 2 4 3.9 C1CNCC(C1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl)F
CHEMBL1083717 acm1_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
343 4 2 2 4.1 CC1=CC(=C(C=C1)C(=O)NCC2CCNCC2)C3=CC(=CC=C3)Cl
CHEMBL1084804 acm1_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
329 4 2 2 3.5 C1CNCCC1NC(=O)CC2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL1083419 acm1_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
343 4 2 2 4.1 CC1=C(C=C(C=C1)Cl)C2=CC=CC=C2C(=O)NCC3CCNCC3
CHEMBL1083317 acm1_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
397 4 2 4 3.6 C1CNCC(=C1CNC(=O)C2=C(C=CC(=C2F)Cl)C3=CC(=CC=C3)Cl)F
CHEMBL1083927 acm1_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
393 4 2 3 4.1 CC1CNCC=C1CNC(=O)C2=C(C=CC(=C2F)Cl)C3=CC(=CC=C3)Cl
CHEMBL1083003 acm1_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
365 4 2 4 3.9 C1CNCC(C1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl)F
CHEMBL1083717 acm1_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
343 4 2 2 4.1 CC1=CC(=C(C=C1)C(=O)NCC2CCNCC2)C3=CC(=CC=C3)Cl
CHEMBL1084804 acm1_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
329 4 2 2 3.5 C1CNCCC1NC(=O)CC2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL1083419 acm1_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
343 4 2 2 4.1 CC1=C(C=C(C=C1)Cl)C2=CC=CC=C2C(=O)NCC3CCNCC3
CHEMBL1083317 acm1_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
397 4 2 4 3.6 C1CNCC(=C1CNC(=O)C2=C(C=CC(=C2F)Cl)C3=CC(=CC=C3)Cl)F
CHEMBL3290086 acm1_human Human No 5.8 EC50 = 1584.9 Funct
Activation of human M1 mAChR expressed in FlpIn-CHO cells assessed as FBS-induced ERK1/2 phosphorylation incubated for 5 mins by Alphascreen assayActivation of human M1 mAChR expressed in FlpIn-CHO cells assessed as FBS-induced ERK1/2 phosphorylation incubated for 5 mins by Alphascreen assay
415 5 2 5 3.4 C1=CC=C2C(=C1)C(=O)C(=CN2CC3=CC=C(C=C3)NC(=O)CBr)C(=O)O
CHEMBL965 acm1_human Human Yes 5.8 EC50 = 1584.9 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assay
147 4 1 2 -0.4 C[N+](C)(C)CCOC(=O)N
CHEMBL1083107 acm1_human Human No 5.8 EC50 = 1584.9 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
343 4 2 2 4.1 CC1=CC(=CC(=C1)C2=CC=CC=C2C(=O)NCC3CCNCC3)Cl
CHEMBL1083401 acm1_human Human No 5.8 EC50 = 1584.9 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
411 6 1 5 3.7 CS(=O)(=O)N(CC1CCNCC1)CC2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL3290086 acm1_human Human No 5.8 EC50 = 1584.9 Funct
Activation of human M1 mAChR expressed in FlpIn-CHO cells assessed as FBS-induced ERK1/2 phosphorylation incubated for 5 mins by Alphascreen assayActivation of human M1 mAChR expressed in FlpIn-CHO cells assessed as FBS-induced ERK1/2 phosphorylation incubated for 5 mins by Alphascreen assay
415 5 2 5 3.4 C1=CC=C2C(=C1)C(=O)C(=CN2CC3=CC=C(C=C3)NC(=O)CBr)C(=O)O
CHEMBL965 acm1_human Human Yes 5.8 EC50 = 1584.9 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assay
147 4 1 2 -0.4 C[N+](C)(C)CCOC(=O)N
CHEMBL1083107 acm1_human Human No 5.8 EC50 = 1584.9 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
343 4 2 2 4.1 CC1=CC(=CC(=C1)C2=CC=CC=C2C(=O)NCC3CCNCC3)Cl
CHEMBL1083401 acm1_human Human No 5.8 EC50 = 1584.9 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
411 6 1 5 3.7 CS(=O)(=O)N(CC1CCNCC1)CC2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL1169506 acm1_human Human No 6.8 EC50 = 159 Funct
Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptorStimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptor
311 4 0 5 2.8 C1CN2CC1C(C2)C3=NSN=C3OCC#CC4=CC=CC=C4
CHEMBL2059305 acm1_human Human No 6.8 EC50 = 160 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
388 5 1 2 4.0 C1CN(CCC1C2=CC3=C(C=C2)NC=C3)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL1243295 acm1_human Human No 6.8 EC50 = 160 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
371 6 1 4 2.3 C1CC(C1)C(=O)NC2CCN(CC2)CCCN3C(=O)COC4=CC=CC=C43
CHEMBL2059305 acm1_human Human No 6.8 EC50 = 160 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
388 5 1 2 4.0 C1CN(CCC1C2=CC3=C(C=C2)NC=C3)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL1243295 acm1_human Human No 6.8 EC50 = 160 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
371 6 1 4 2.3 C1CC(C1)C(=O)NC2CCN(CC2)CCCN3C(=O)COC4=CC=CC=C43
CHEMBL491208 acm1_human Human No 5.8 EC50 = 1600 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
450 4 1 4 3.8 C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5C#N
CHEMBL491208 acm1_human Human No 5.8 EC50 = 1600 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
450 4 1 4 3.8 C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5C#N
CHEMBL3608418 acm1_rat Rat No 6.8 EC50 = 162.5 Funct
Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
405 4 2 5 1.0 CN1C2=C(C=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5COCCC5O)C=N1
CHEMBL3608418 acm1_rat Rat No 6.8 EC50 = 162.5 Funct
Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
405 4 2 5 1.0 CN1C2=C(C=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5COCCC5O)C=N1
CHEMBL3746599 acm1_human Human No 6.8 EC50 = 163 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
415 5 2 3 3.5 C1CCC(C(C1)NC(=O)C2=CN(C3=CC=CC=C32)CC4=CC=C(C=C4)N5C=CC=N5)O
CHEMBL3746599 acm1_human Human No 6.8 EC50 = 163 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
415 5 2 3 3.5 C1CCC(C(C1)NC(=O)C2=CN(C3=CC=CC=C32)CC4=CC=C(C=C4)N5C=CC=N5)O
CHEMBL129764 acm1_human Human No 6.8 EC50 = 164.8 Funct
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
297 7 0 6 3.4 CCCCCOC1=NSN=C1OC2CN3CCC2CC3
CHEMBL3354068 acm1_human Human No 6.8 EC50 = 166.0 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assay
566 14 0 7 6.0 CN1CCC=C(C1)C2=NSN=C2OCCCCCCCC3CCN(CC3)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL3354068 acm1_human Human No 6.8 EC50 = 166.0 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assay
566 14 0 7 6.0 CN1CCC=C(C1)C2=NSN=C2OCCCCCCCC3CCN(CC3)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL3616498 acm1_human Human No 6.8 EC50 = 166 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
462 7 2 5 3.3 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)OC)O)C=C1)N(C)CC4=CC=C(C=C4)F
CHEMBL3616498 acm1_human Human No 6.8 EC50 = 166 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
462 7 2 5 3.3 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)OC)O)C=C1)N(C)CC4=CC=C(C=C4)F
CHEMBL3823999 acm1_rat Rat No 5.8 EC50 = 1698.2 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
393 3 0 5 2.0 CN1C=C2C(=N1)C=CC=C2C3=CC(=C(C(=C3)F)CN4C=CC5=NCCN5C4=O)F
CHEMBL2024331 acm1_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human muscarinic M1 receptor by calcium mobilization assayAgonist activity at human muscarinic M1 receptor by calcium mobilization assay
400 5 1 4 3.6 CCOC(=O)N1C2CCC1CC(C2)N3CCCC(C3)NC(=O)C4=CC=CC=C4C
CHEMBL2024331 acm1_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human muscarinic M1 receptor by calcium mobilization assayAgonist activity at human muscarinic M1 receptor by calcium mobilization assay
400 5 1 4 3.6 CCOC(=O)N1C2CCC1CC(C2)N3CCCC(C3)NC(=O)C4=CC=CC=C4C
CHEMBL3084456 acm1_human Human No 6.8 EC50 = 170 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
351 7 2 5 1.9 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3=CC=CS3
CHEMBL3084448 acm1_human Human No 6.8 EC50 = 170 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
359 7 2 4 2.2 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3=CC=CC=C3C
CHEMBL3084456 acm1_human Human No 6.8 EC50 = 170 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
351 7 2 5 1.9 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3=CC=CS3
CHEMBL3084448 acm1_human Human No 6.8 EC50 = 170 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
359 7 2 4 2.2 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3=CC=CC=C3C
CHEMBL305264 acm1_human Human No 6.8 EC50 = 170 Funct
In Vitro evaluation activity at the cloned Human Muscarinic acetylcholine receptor M1 determined by receptor selection and amplification technology (R-SAT)In Vitro evaluation activity at the cloned Human Muscarinic acetylcholine receptor M1 determined by receptor selection and amplification technology (R-SAT)
196 2 1 4 1.1 CC(C)OC1=NOC2=C1CNCCC2
CHEMBL2059313 acm1_human Human No 5.8 EC50 = 1700 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
407 5 1 5 1.8 C1CN(CCC1N2C3=C(C=CC=N3)NC2=O)CCCN4C(=O)COC5=CC=CC=C54
CHEMBL3823999 acm1_rat Rat No 5.8 EC50 = 1700 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
393 3 0 5 2.0 CN1C=C2C(=N1)C=CC=C2C3=CC(=C(C(=C3)F)CN4C=CC5=NCCN5C4=O)F
CHEMBL3823424 acm1_rat Rat No 5.8 EC50 = 1700 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
393 3 0 5 2.7 CN1C=C2C=C(C=CC2=N1)C3=CC(=C(C(=C3)F)CN4CCN5C(=CC=N5)C4=O)F
CHEMBL2059313 acm1_human Human No 5.8 EC50 = 1700 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
407 5 1 5 1.8 C1CN(CCC1N2C3=C(C=CC=N3)NC2=O)CCCN4C(=O)COC5=CC=CC=C54
CHEMBL3823999 acm1_rat Rat No 5.8 EC50 = 1700 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
393 3 0 5 2.0 CN1C=C2C(=N1)C=CC=C2C3=CC(=C(C(=C3)F)CN4C=CC5=NCCN5C4=O)F
CHEMBL3823424 acm1_rat Rat No 5.8 EC50 = 1700 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
393 3 0 5 2.7 CN1C=C2C=C(C=CC2=N1)C3=CC(=C(C(=C3)F)CN4CCN5C(=CC=N5)C4=O)F
CHEMBL3354068 acm1_human Human No 6.8 EC50 = 173.8 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based beta-arrestin engagement assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based beta-arrestin engagement assay
566 14 0 7 6.0 CN1CCC=C(C1)C2=NSN=C2OCCCCCCCC3CCN(CC3)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL3354068 acm1_human Human No 6.8 EC50 = 173.8 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based beta-arrestin engagement assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based beta-arrestin engagement assay
566 14 0 7 6.0 CN1CCC=C(C1)C2=NSN=C2OCCCCCCCC3CCN(CC3)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL3747254 acm1_human Human No 6.8 EC50 = 175 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
401 6 1 4 2.3 C1CC(OC1)CNC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)N5C=CC=N5
CHEMBL3747254 acm1_human Human No 6.8 EC50 = 175 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
401 6 1 4 2.3 C1CC(OC1)CNC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)N5C=CC=N5
CHEMBL3084447 acm1_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human muscarinic M1 receptor by calcium mobilization assayAgonist activity at human muscarinic M1 receptor by calcium mobilization assay
345 7 2 4 1.9 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3=CC=CC=C3
CHEMBL3608421 acm1_rat Rat No 7.8 EC50 = 18 Funct
Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
449 5 2 6 1.4 CN1C=C(C=N1)C2=C(C=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5COCCC5O)F
CHEMBL3608422 acm1_rat Rat No 7.8 EC50 = 18 Funct
Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
408 5 3 5 0.6 CNC(=O)C1=CC=C(C=C1)CN2C=C(C3=C2C=CC=N3)C(=O)NC4COCCC4O
CHEMBL3084447 acm1_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human muscarinic M1 receptor by calcium mobilization assayAgonist activity at human muscarinic M1 receptor by calcium mobilization assay
345 7 2 4 1.9 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3=CC=CC=C3
CHEMBL3608421 acm1_rat Rat No 7.8 EC50 = 18 Funct
Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
449 5 2 6 1.4 CN1C=C(C=N1)C2=C(C=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5COCCC5O)F
CHEMBL3608422 acm1_rat Rat No 7.8 EC50 = 18 Funct
Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
408 5 3 5 0.6 CNC(=O)C1=CC=C(C=C1)CN2C=C(C3=C2C=CC=N3)C(=O)NC4COCCC4O
CHEMBL1243202 acm1_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
331 5 1 4 1.3 CC(=O)NC1CCN(CC1)CCCN2C(=O)COC3=CC=CC=C32
CHEMBL1492697 acm1_human Human Yes 6.8 EC50 = 180 Funct
Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayPositive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assay
287 1 1 2 3.5 C1C(=S)NC2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3
CHEMBL1243202 acm1_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
331 5 1 4 1.3 CC(=O)NC1CCN(CC1)CCCN2C(=O)COC3=CC=CC=C32
CHEMBL140985 acm1_human Human No 6.8 EC50 = 180 Funct
Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.
523 12 0 10 4.7 CN1CCC=C(C1)C2=NSN=C2SCCCCCCCSC3=NSN=C3C4=CCCN(C4)C
CHEMBL515489 acm1_human Human No 5.8 EC50 = 1800 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
459 4 1 3 4.7 C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5Cl
CHEMBL515489 acm1_human Human No 5.8 EC50 = 1800 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
459 4 1 3 4.7 C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5Cl
CHEMBL60479 acm1_human Human No 5.7 EC50 = 1810 Funct
Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.
394 4 0 5 4.3 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC(=CC(=C5)Cl)Cl
CHEMBL2333481 acm1_human Human No 5.7 EC50 = 1819.7 Funct
Positive allosteric modulation of human muscarinic M1 receptorPositive allosteric modulation of human muscarinic M1 receptor
427 4 0 3 3.7 CN1C=C(C=N1)C2=CC=C(C=C2)CN3C4=CC=CC=C4C5(C3=O)CCN(C5)C6CCCC6
CHEMBL3618446 acm1_human Human No 6.7 EC50 = 183 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
510 7 3 4 4.2 CC(=NCCC1=CC=C(C=C1)F)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3618446 acm1_human Human No 6.7 EC50 = 183 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
510 7 3 4 4.2 CC(=NCCC1=CC=C(C=C1)F)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3746904 acm1_human Human No 6.7 EC50 = 185 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
400 4 2 4 2.8 C1CCC(C(C1)NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC5=C(C=C4)N=CC=C5)O
CHEMBL3746904 acm1_human Human No 6.7 EC50 = 185 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
400 4 2 4 2.8 C1CCC(C(C1)NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC5=C(C=C4)N=CC=C5)O
CHEMBL1773111 acm1_rat Rat No 5.7 EC50 = 1850 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
512 7 2 8 3.6 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC(=CC(=C32)F)F)CC4=CC=CC(=C4)C5=CNN=C5
CHEMBL1773111 acm1_rat Rat No 5.7 EC50 = 1850 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
512 7 2 8 3.6 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC(=CC(=C32)F)F)CC4=CC=CC(=C4)C5=CNN=C5
CHEMBL965 acm1_human Human Yes 4.7 EC50 = 18620.9 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based beta-arrestin engagement assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based beta-arrestin engagement assay
147 4 1 2 -0.4 C[N+](C)(C)CCOC(=O)N
CHEMBL965 acm1_human Human Yes 4.7 EC50 = 18620.9 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based beta-arrestin engagement assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based beta-arrestin engagement assay
147 4 1 2 -0.4 C[N+](C)(C)CCOC(=O)N
CHEMBL1243328 acm1_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
361 6 1 4 2.1 CCC(=O)NC1CCN(CC1)CCCN2C(=O)CCC3=C2C=CC=C3F
CHEMBL1243328 acm1_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
361 6 1 4 2.1 CCC(=O)NC1CCN(CC1)CCCN2C(=O)CCC3=C2C=CC=C3F
CHEMBL1084993 acm1_human Human No 7.7 EC50 = 20.0 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
343 4 2 2 4.2 CC1CNCCC1CNC(=O)C2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL1083926 acm1_human Human No 7.7 EC50 = 20.0 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
361 4 2 3 4.3 CC1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL1084993 acm1_human Human No 7.7 EC50 = 20.0 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
343 4 2 2 4.2 CC1CNCCC1CNC(=O)C2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL1083926 acm1_human Human No 7.7 EC50 = 20.0 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
361 4 2 3 4.3 CC1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL2024423 acm1_human Human No 5.7 EC50 = 1900 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
381 7 2 6 2.4 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC(=CC(=C3)F)F
CHEMBL3823130 acm1_human Human No 5.7 EC50 = 1900 Funct
Positive allosteric modulation at human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
322 3 0 4 1.5 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3CC4=C(C3=O)C=CC=N4)F
CHEMBL2024423 acm1_human Human No 5.7 EC50 = 1900 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
381 7 2 6 2.4 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC(=CC(=C3)F)F
CHEMBL354738 acm1_human Human No 5.7 EC50 = 1900 Funct
Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholine receptor M1Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholine receptor M1
178 2 0 3 1.2 CC#CCON=C1CN2CCC1C2
CHEMBL3823130 acm1_human Human No 5.7 EC50 = 1900 Funct
Positive allosteric modulation at human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
322 3 0 4 1.5 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3CC4=C(C3=O)C=CC=N4)F
CHEMBL3360949 acm1_human Human No 5.7 EC50 = 1940 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
492 5 0 5 5.2 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=C(C=C(C=C5)C6=CN(N=C6)C)F)C
CHEMBL3360949 acm1_human Human No 5.7 EC50 = 1949.8 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
492 5 0 5 5.2 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=C(C=C(C=C5)C6=CN(N=C6)C)F)C
CHEMBL3360949 acm1_human Human No 5.7 EC50 = 1949.8 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
492 5 0 5 5.2 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=C(C=C(C=C5)C6=CN(N=C6)C)F)C
CHEMBL3618441 acm1_human Human No 6.7 EC50 = 198 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
508 7 3 4 3.8 CC(=NCC1=CC(=CC=C1)OC)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3618441 acm1_human Human No 6.7 EC50 = 198 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
508 7 3 4 3.8 CC(=NCC1=CC(=CC=C1)OC)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL1223938 acm1_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
451 6 0 6 3.3 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)CC)OC3=O
CHEMBL1223938 acm1_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
451 6 0 6 3.3 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)CC)OC3=O
CHEMBL216927 acm1_human Human Yes 5.7 EC50 = 1995.3 Funct
Agonist activity at human M1 receptor E170K mutant expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor E170K mutant expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
488 16 0 13 1.2 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOC3=NSN=C3OC
CHEMBL216927 acm1_human Human Yes 5.7 EC50 = 1995.3 Funct
Agonist activity at human M1 receptor E170K mutant expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor E170K mutant expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
488 16 0 13 1.2 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOC3=NSN=C3OC
CHEMBL2333477 acm1_human Human No 5.7 EC50 = 1995.3 Funct
Positive allosteric modulation of human muscarinic M1 receptorPositive allosteric modulation of human muscarinic M1 receptor
445 4 0 4 3.8 CN1C=C(C=N1)C2=C(C=C(C=C2)CN3C4=CC=CC=C4C5(C3=O)CCN(C5)C6CCCC6)F
CHEMBL491209 acm1_human Human No 8.7 EC50 = 2.1 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
372 4 1 4 2.8 CCOC(=O)N1CCC(CC1)N2CCC(CC2)N3C4=CC=CC=C4NC3=O
CHEMBL491209 acm1_human Human No 8.7 EC50 = 2.1 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
372 4 1 4 2.8 CCOC(=O)N1CCC(CC1)N2CCC(CC2)N3C4=CC=CC=C4NC3=O
CHEMBL293982 acm1_human Human No 8.6 EC50 = 2.5 Funct
Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.
343 4 0 6 3.2 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC(=CC=C5)F
CHEMBL1223862 acm1_human Human No 8.6 EC50 = 2.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
389 5 0 5 3.6 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)OC)OC3=O
CHEMBL1223939 acm1_human Human No 8.6 EC50 = 2.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
451 6 0 6 3.4 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)C)OC3=O
CHEMBL1223940 acm1_human Human No 8.6 EC50 = 2.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
403 6 0 5 3.5 CC1=CC2=C(C=C1)OC(=O)N2C3CCN(CC3)C4(CCC(CC4)OCCOC)C
CHEMBL1223862 acm1_human Human No 8.6 EC50 = 2.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
389 5 0 5 3.6 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)OC)OC3=O
CHEMBL1223939 acm1_human Human No 8.6 EC50 = 2.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
451 6 0 6 3.4 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)C)OC3=O
CHEMBL1223940 acm1_human Human No 8.6 EC50 = 2.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
403 6 0 5 3.5 CC1=CC2=C(C=C1)OC(=O)N2C3CCN(CC3)C4(CCC(CC4)OCCOC)C
CHEMBL2059310 acm1_human Human No 7.7 EC50 = 20 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
406 5 1 4 2.0 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCN4C(=O)CCC5=C4N=CC=C5
CHEMBL1243387 acm1_human Human No 7.7 EC50 = 20 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
379 6 1 5 2.2 CCC(=O)NC1CCN(CC1)CCCN2C(=O)CCC3=CC(=C(C=C32)F)F
CHEMBL1243358 acm1_human Human No 7.7 EC50 = 20 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
361 6 1 4 2.1 CCC(=O)NC1CCN(CC1)CCCN2C(=O)CCC3=C2C=C(C=C3)F
CHEMBL2059310 acm1_human Human No 7.7 EC50 = 20 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
406 5 1 4 2.0 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCN4C(=O)CCC5=C4N=CC=C5
CHEMBL1243387 acm1_human Human No 7.7 EC50 = 20 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
379 6 1 5 2.2 CCC(=O)NC1CCN(CC1)CCCN2C(=O)CCC3=CC(=C(C=C32)F)F
CHEMBL1243358 acm1_human Human No 7.7 EC50 = 20 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
361 6 1 4 2.1 CCC(=O)NC1CCN(CC1)CCCN2C(=O)CCC3=C2C=C(C=C3)F
CHEMBL291872 acm1_human Human No 7.7 EC50 = 20.2 Funct
Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.
345 4 0 7 2.7 C1C2C3C2(CN1C3)C4=NSN=C4OCC#CC5=CC(=CC(=C5)F)F
CHEMBL3354067 acm1_human Human No 7.7 EC50 = 20.4 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assay
538 12 0 7 4.9 CN1CCC=C(C1)C2=NSN=C2OCCCCCC3CCN(CC3)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL3354067 acm1_human Human No 7.7 EC50 = 20.4 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assay
538 12 0 7 4.9 CN1CCC=C(C1)C2=NSN=C2OCCCCCC3CCN(CC3)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL3618440 acm1_human Human No 7.7 EC50 = 20.9 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
496 6 3 4 3.9 CC(=NCC1=CC=C(C=C1)F)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3618440 acm1_human Human No 7.7 EC50 = 20.9 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
496 6 3 4 3.9 CC(=NCC1=CC=C(C=C1)F)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3084451 acm1_human Human No 6.7 EC50 = 200 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
381 7 2 6 2.1 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3=CC(=CC(=C3)F)F
CHEMBL1624037 acm1_rat Rat No 6.7 EC50 = 200 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
333 7 2 4 2.0 CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C
CHEMBL3084451 acm1_human Human No 6.7 EC50 = 200 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
381 7 2 6 2.1 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3=CC(=CC(=C3)F)F
CHEMBL1624037 acm1_rat Rat No 6.7 EC50 = 200 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
333 7 2 4 2.0 CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C
CHEMBL1609153 acm1_rat Rat Yes 6.7 EC50 = 200 Funct
Partial agonist activity at rat muscarinic M1 receptor expressed in CHO cells calcium responsePartial agonist activity at rat muscarinic M1 receptor expressed in CHO cells calcium response
319 7 2 4 1.6 CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2
CHEMBL3329755 acm1_rat Rat Yes 5.7 EC50 = 2000 Funct
Activity at rat muscarinic acetylcholine receptor subtype 1 expressed in CHO cells by calcium mobilization assayActivity at rat muscarinic acetylcholine receptor subtype 1 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL2022944 acm1_human Human No 5.7 EC50 = 2000 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
354 6 2 5 0.2 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)N3CCOCC3
CHEMBL2024410 acm1_human Human No 5.7 EC50 = 2000 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
357 8 2 4 2.5 C=CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3
CHEMBL3329755 acm1_rat Rat Yes 5.7 EC50 = 2000 Funct
Activity at rat muscarinic acetylcholine receptor subtype 1 expressed in CHO cells by calcium mobilization assayActivity at rat muscarinic acetylcholine receptor subtype 1 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL2022944 acm1_human Human No 5.7 EC50 = 2000 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
354 6 2 5 0.2 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)N3CCOCC3
CHEMBL2024410 acm1_human Human No 5.7 EC50 = 2000 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
357 8 2 4 2.5 C=CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3
CHEMBL2333875 acm1_human Human Yes 5.7 EC50 = 2000 Funct
Positive allosteric modulation of human muscarinic M1 receptorPositive allosteric modulation of human muscarinic M1 receptor
379 3 0 5 2.0 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=CC=CC=C4C5(C3=O)OCCO5)F
CHEMBL3360940 acm1_human Human No 5.7 EC50 = 2020 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
411 4 0 4 5.2 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC=C(C=C5)F)C
CHEMBL3354073 acm1_human Human No 6.7 EC50 = 204.2 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assay
359 9 1 3 3.5 C1CN(CCC1CCCCCO)CCCN2C(=O)CCC3=CC=CC=C32
CHEMBL3354073 acm1_human Human No 6.7 EC50 = 204.2 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assay
359 9 1 3 3.5 C1CN(CCC1CCCCCO)CCCN2C(=O)CCC3=CC=CC=C32
CHEMBL3360940 acm1_human Human No 5.7 EC50 = 2041.7 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
411 4 0 4 5.2 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC=C(C=C5)F)C
CHEMBL2315678 acm1_rat Rat No 5.7 EC50 = 2041.7 Funct
Partial agonist activity at rat muscarinic M1 receptor expressed in CHO cells calcium responsePartial agonist activity at rat muscarinic M1 receptor expressed in CHO cells calcium response
438 5 1 4 3.3 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC(=CC=C3)Br
CHEMBL3360940 acm1_human Human No 5.7 EC50 = 2041.7 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
411 4 0 4 5.2 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC=C(C=C5)F)C
CHEMBL151938 acm1_human Human Yes 7.7 EC50 = 21 Funct
Agonist activity at human m1 muscarinic acetylcholine receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human m1 muscarinic acetylcholine receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
154 2 0 3 0.7 CN1CCC=C(C1)C=NOC
CHEMBL151938 acm1_human Human Yes 7.7 EC50 = 21 Funct
Agonist activity at human m1 muscarinic acetylcholine receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human m1 muscarinic acetylcholine receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
154 2 0 3 0.7 CN1CCC=C(C1)C=NOC
CHEMBL2024407 acm1_human Human No 6.7 EC50 = 210 Funct
Agonist activity at human muscarinic M1 receptor by calcium mobilization assayAgonist activity at human muscarinic M1 receptor by calcium mobilization assay
345 7 2 4 2.2 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3
CHEMBL2024408 acm1_human Human No 6.7 EC50 = 210 Funct
Agonist activity at human muscarinic M1 receptor by calcium mobilization assayAgonist activity at human muscarinic M1 receptor by calcium mobilization assay
345 7 2 4 2.2 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3
CHEMBL2024329 acm1_human Human No 5.7 EC50 = 2100 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
400 5 1 4 3.6 CCOC(=O)N1C2CCC1CC(C2)N3CCCC(C3)NC(=O)C4=CC=CC=C4C
CHEMBL485913 acm1_human Human No 5.7 EC50 = 2100 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
387 6 2 5 1.9 C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CCOC(=O)N
CHEMBL2024329 acm1_human Human No 5.7 EC50 = 2100 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
400 5 1 4 3.6 CCOC(=O)N1C2CCC1CC(C2)N3CCCC(C3)NC(=O)C4=CC=CC=C4C
CHEMBL485913 acm1_human Human No 5.7 EC50 = 2100 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
387 6 2 5 1.9 C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CCOC(=O)N
CHEMBL143434 acm1_human Human No 5.7 EC50 = 2100 Funct
Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.
565 15 0 10 6.3 CN1CCC=C(C1)C2=NSN=C2SCCCCCCCCCCSC3=NSN=C3C4=CCCN(C4)C
CHEMBL3747004 acm1_human Human No 6.7 EC50 = 211 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
446 5 2 5 1.7 CC1=CC2=C(C(=CN2CC3=CC=C(C=C3)C4=NN(C=C4)C)C(=O)NC5CCOCC5O)N=C1
CHEMBL3747004 acm1_human Human No 6.7 EC50 = 211 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
446 5 2 5 1.7 CC1=CC2=C(C(=CN2CC3=CC=C(C=C3)C4=NN(C=C4)C)C(=O)NC5CCOCC5O)N=C1
CHEMBL471636 acm1_human Human No 5.7 EC50 = 2110 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
453 3 1 3 4.0 CC1=CC=CC(=C1)C(=O)N2CCC(CC2)N3CCC(CC3)N4C5=C(C=C(C=C5)Cl)NC4=O
CHEMBL471636 acm1_human Human No 5.7 EC50 = 2110 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
453 3 1 3 4.0 CC1=CC=CC(=C1)C(=O)N2CCC(CC2)N3CCC(CC3)N4C5=C(C=C(C=C5)Cl)NC4=O
CHEMBL3746104 acm1_human Human No 6.7 EC50 = 215 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
416 5 2 5 2.4 C1CCC(C(C1)NC(=O)C2=NN(C3=C2N=CC=C3)CC4=CC=C(C=C4)N5C=CC=N5)O
CHEMBL3746104 acm1_human Human No 6.7 EC50 = 215 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
416 5 2 5 2.4 C1CCC(C(C1)NC(=O)C2=NN(C3=C2N=CC=C3)CC4=CC=C(C=C4)N5C=CC=N5)O
CHEMBL12587 acm1_rat Rat Yes 6.7 EC50 = 219 Funct
Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M1Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M1
174 2 1 2 0.1 CC1C(CC(O1)C[N+](C)(C)C)O
CHEMBL1773100 acm1_rat Rat No 5.7 EC50 = 2190 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
476 7 2 6 3.4 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC=CC(=C4)C5=CNN=C5
CHEMBL1773100 acm1_rat Rat No 5.7 EC50 = 2190 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
476 7 2 6 3.4 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC=CC(=C4)C5=CNN=C5
CHEMBL433867 acm1_human Human No 7.7 EC50 = 22.3 Funct
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
299 6 0 6 3.4 CCCCSC1=NSN=C1OC2CN3CCC2CC3
CHEMBL3616501 acm1_human Human Yes 7.6 EC50 = 22.8 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
508 7 2 4 5.0 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)C4=CC=CC=C4)O)C=C1)N(C)CC5=CC=C(C=C5)F
CHEMBL3616501 acm1_human Human Yes 7.6 EC50 = 22.8 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
508 7 2 4 5.0 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)C4=CC=CC=C4)O)C=C1)N(C)CC5=CC=C(C=C5)F
CHEMBL2024406 acm1_human Human No 5.7 EC50 = 2200 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
357 5 1 4 2.5 CCOC(=O)N1C2CCC1CC(C2)N3CC(C3)NC(=O)C4=CC=CC=C4
CHEMBL2024406 acm1_human Human No 5.7 EC50 = 2200 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
357 5 1 4 2.5 CCOC(=O)N1C2CCC1CC(C2)N3CC(C3)NC(=O)C4=CC=CC=C4
CHEMBL126237 acm1_human Human No 6.7 EC50 = 225 Funct
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
328 8 0 6 4.5 CCCCCCSC1=NSN=C1OC2CN3CCC2CC3
CHEMBL3354074 acm1_human Human No 6.6 EC50 = 229.1 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assay
387 11 1 3 4.6 C1CN(CCC1CCCCCCCO)CCCN2C(=O)CCC3=CC=CC=C32
CHEMBL3354074 acm1_human Human No 6.6 EC50 = 229.1 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assay
387 11 1 3 4.6 C1CN(CCC1CCCCCCCO)CCCN2C(=O)CCC3=CC=CC=C32
CHEMBL64000 acm1_rat Rat No 7.6 EC50 = 23 Funct
Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M1Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M1
169 2 1 3 0.9 CC(=O)OC1CC2CCCC1N2
CHEMBL2024419 acm1_human Human No 5.6 EC50 = 2300 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
380 7 2 4 2.8 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3Cl
CHEMBL1624037 acm1_human Human No 5.6 EC50 = 2300 Funct
Agonist activity at human recombinant muscarinic M1 receptor by HTS cell based assayAgonist activity at human recombinant muscarinic M1 receptor by HTS cell based assay
333 7 2 4 2.0 CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C
CHEMBL485755 acm1_human Human No 5.6 EC50 = 2300 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
459 4 1 6 2.8 C1CN(CCC1N2C3=C(C=C(C=C3)F)NC2=O)C4CCN(CC4)S(=O)(=O)C5=CC=CC=C5
CHEMBL1624037 acm1_rat Rat No 5.6 EC50 = 2300 Funct
Agonist activity at rat recombinant muscarinic M1 receptor by HTS cell based assayAgonist activity at rat recombinant muscarinic M1 receptor by HTS cell based assay
333 7 2 4 2.0 CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C
CHEMBL1084941 acm1_human Human No 5.6 EC50 = 2300 Funct
Potentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPotentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
317 3 0 3 2.3 CN1C=C(C=N1)C2=CC=C(C=C2)CN3C4=CC=CC=C4C(=O)C3=O
CHEMBL1083205 acm1_human Human No 5.6 EC50 = 2300 Funct
Potentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPotentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
353 3 0 5 2.5 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=C(C=CC=C4F)C(=O)C3=O)F
CHEMBL2024419 acm1_human Human No 5.6 EC50 = 2300 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
380 7 2 4 2.8 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3Cl
CHEMBL1624037 acm1_human Human No 5.6 EC50 = 2300 Funct
Agonist activity at human recombinant muscarinic M1 receptor by HTS cell based assayAgonist activity at human recombinant muscarinic M1 receptor by HTS cell based assay
333 7 2 4 2.0 CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C
CHEMBL485755 acm1_human Human No 5.6 EC50 = 2300 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
459 4 1 6 2.8 C1CN(CCC1N2C3=C(C=C(C=C3)F)NC2=O)C4CCN(CC4)S(=O)(=O)C5=CC=CC=C5
CHEMBL1624037 acm1_rat Rat No 5.6 EC50 = 2300 Funct
Agonist activity at rat recombinant muscarinic M1 receptor by HTS cell based assayAgonist activity at rat recombinant muscarinic M1 receptor by HTS cell based assay
333 7 2 4 2.0 CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C
CHEMBL1084941 acm1_human Human No 5.6 EC50 = 2300 Funct
Potentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPotentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
317 3 0 3 2.3 CN1C=C(C=N1)C2=CC=C(C=C2)CN3C4=CC=CC=C4C(=O)C3=O
CHEMBL1083205 acm1_human Human No 5.6 EC50 = 2300 Funct
Potentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPotentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
353 3 0 5 2.5 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=C(C=CC=C4F)C(=O)C3=O)F
CHEMBL1083205 acm1_rat Rat No 5.6 EC50 = 2320 Funct
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]
353 3 0 5 2.5 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=C(C=CC=C4F)C(=O)C3=O)F
CHEMBL1083205 acm1_rat Rat No 5.6 EC50 = 2320 Funct
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]
353 3 0 5 2.5 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=C(C=CC=C4F)C(=O)C3=O)F
CHEMBL3084450 acm1_human Human No 6.6 EC50 = 240 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
375 8 2 5 1.9 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3=CC(=CC=C3)OC
CHEMBL3084450 acm1_human Human No 6.6 EC50 = 240 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
375 8 2 5 1.9 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3=CC(=CC=C3)OC
CHEMBL2313520 acm1_human Human No 5.6 EC50 = 2400 Funct
Positive allosteric modulator activity at human muscarinic M1 receptor by calcium mobilization assayPositive allosteric modulator activity at human muscarinic M1 receptor by calcium mobilization assay
321 3 0 3 2.5 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C(=O)CC4=CC=CC=C43)F
CHEMBL1084941 acm1_rat Rat No 5.6 EC50 = 2420 Funct
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]
317 3 0 3 2.3 CN1C=C(C=N1)C2=CC=C(C=C2)CN3C4=CC=CC=C4C(=O)C3=O
CHEMBL1084941 acm1_rat Rat No 5.6 EC50 = 2420 Funct
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]
317 3 0 3 2.3 CN1C=C(C=N1)C2=CC=C(C=C2)CN3C4=CC=CC=C4C(=O)C3=O
CHEMBL3360958 acm1_human Human No 5.6 EC50 = 2430 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
355 3 0 4 2.9 CN1C(=O)C2=CN(C3=CC=CC=C3C2=N1)CC4=CC=C(C=C4)N5C=CC=N5
CHEMBL3360958 acm1_human Human No 5.6 EC50 = 2430 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
355 3 0 4 2.9 CN1C(=O)C2=CN(C3=CC=CC=C3C2=N1)CC4=CC=C(C=C4)N5C=CC=N5
CHEMBL2333472 acm1_human Human No 5.6 EC50 = 2454.7 Funct
Positive allosteric modulation of human muscarinic M1 receptorPositive allosteric modulation of human muscarinic M1 receptor
455 4 0 6 2.9 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=CC=CC=C4C5(C3=O)CCN(C5)C6=NC=CC=N6)F
CHEMBL3745855 acm1_human Human No 6.6 EC50 = 248 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
430 6 2 4 2.7 C1CC(CCC1CO)NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)N5C=CC=N5
CHEMBL3745855 acm1_human Human No 6.6 EC50 = 248 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
430 6 2 4 2.7 C1CC(CCC1CO)NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)N5C=CC=N5
CHEMBL1083621 acm1_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
381 4 2 3 4.5 C1CNCCC1CNC(=O)C2=C(C=CC(=C2F)Cl)C3=CC(=CC=C3)Cl
CHEMBL1084818 acm1_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
347 4 2 3 3.9 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=CC(=C(C=C3)F)Cl
CHEMBL1223807 acm1_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
358 4 0 4 3.7 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=CC=CC=C4OC3=O
CHEMBL1083621 acm1_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
381 4 2 3 4.5 C1CNCCC1CNC(=O)C2=C(C=CC(=C2F)Cl)C3=CC(=CC=C3)Cl
CHEMBL1084818 acm1_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
347 4 2 3 3.9 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=CC(=C(C=C3)F)Cl
CHEMBL1223807 acm1_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
358 4 0 4 3.7 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=CC=CC=C4OC3=O
CHEMBL3608415 acm1_human Human No 7.6 EC50 = 25.3 Funct
Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
449 5 2 6 2.5 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=C(C(=N3)C(=O)NC5CCCCC5O)N=CC=C4)F
CHEMBL3608415 acm1_human Human No 7.6 EC50 = 25.3 Funct
Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
449 5 2 6 2.5 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=C(C(=N3)C(=O)NC5CCCCC5O)N=CC=C4)F
CHEMBL1916228 acm1_rat Rat No 6.6 EC50 = 250 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
389 6 1 5 2.6 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC(=CC=C3)OC
CHEMBL1916228 acm1_rat Rat No 6.6 EC50 = 250 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
389 6 1 5 2.6 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC(=CC=C3)OC
CHEMBL2024427 acm1_human Human No 5.6 EC50 = 2500 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
381 6 2 4 2.3 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)N3C(CCCC3C)C
CHEMBL2024427 acm1_human Human No 5.6 EC50 = 2500 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
381 6 2 4 2.3 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)N3C(CCCC3C)C
CHEMBL216927 acm1_human Human Yes 6.6 EC50 = 251.2 Funct
Agonist activity at human M1 receptor Q185E mutant expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor Q185E mutant expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
488 16 0 13 1.2 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOC3=NSN=C3OC
CHEMBL216928 acm1_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
488 16 0 13 2.1 CN1CCC=CC1C2=NSN=C2OCCOCCOCCOCCOC3=NC(=NS3)OC
CHEMBL386983 acm1_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
532 19 0 14 1.1 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOCCOC3=NSN=C3OC
CHEMBL1083911 acm1_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
336 4 2 4 3.2 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=NC(=CS3)Cl
CHEMBL1082341 acm1_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
362 4 1 4 3.6 C1CN2CCC1(CC2)CNC(=O)C3=CC=CC=C3C4=NC(=CS4)Cl
CHEMBL216927 acm1_human Human Yes 6.6 EC50 = 251.2 Funct
Agonist activity at human M1 receptor Q185E mutant expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor Q185E mutant expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
488 16 0 13 1.2 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOC3=NSN=C3OC
CHEMBL216928 acm1_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
488 16 0 13 2.1 CN1CCC=CC1C2=NSN=C2OCCOCCOCCOCCOC3=NC(=NS3)OC
CHEMBL386983 acm1_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
532 19 0 14 1.1 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOCCOC3=NSN=C3OC
CHEMBL1083911 acm1_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
336 4 2 4 3.2 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=NC(=CS3)Cl
CHEMBL1082341 acm1_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
362 4 1 4 3.6 C1CN2CCC1(CC2)CNC(=O)C3=CC=CC=C3C4=NC(=CS4)Cl
CHEMBL2206333 acm1_human Human No 4.6 EC50 = 25118.9 Funct
Displacement of [3H]NMS from EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells assessed as reduction of [3H]NMS dissociation rate after 22 hrs by liquid scintillation countingDisplacement of [3H]NMS from EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells assessed as reduction of [3H]NMS dissociation rate after 22 hrs by liquid scintillation counting
871 19 1 10 4.8 CCN(CC)C1=CC2=C(C=C1)C(=C3C=CC(=[N+](CC)CC)C=C3O2)C4=C(C=C(C=C4)S(=O)(=O)NCCCCCC5CCN(CC5)CCCC(=O)C6=CC=CC=C6C)S(=O)(=O)[O-]
CHEMBL3745724 acm1_human Human No 6.6 EC50 = 255 Funct
Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as increase in ACh-induced intracellular calcium level preincubated for 10 mins followed by ACh addition measured every 2 secs for 80 secs by Fluo-4 dye-based FLIPR assayPositive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as increase in ACh-induced intracellular calcium level preincubated for 10 mins followed by ACh addition measured every 2 secs for 80 secs by Fluo-4 dye-based FLIPR assay
446 5 2 5 1.7 CC1=NC2=C(C=C1)N(C=C2C(=O)NC3CCOCC3O)CC4=CC=C(C=C4)C5=NN(C=C5)C
CHEMBL3747724 acm1_human Human No 6.6 EC50 = 258 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
397 5 1 4 2.1 CN1C=CC(=N1)NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)N5C=CC=N5
CHEMBL3747724 acm1_human Human No 6.6 EC50 = 258 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
397 5 1 4 2.1 CN1C=CC(=N1)NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)N5C=CC=N5
CHEMBL126332 acm1_human Human No 6.6 EC50 = 258.9 Funct
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
311 8 0 6 3.9 CCCCCCOC1=NSN=C1OC2CN3CCC2CC3
CHEMBL477821 acm1_human Human No 6.6 EC50 = 260 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
425 4 1 3 4.1 C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5Cl
CHEMBL477821 acm1_human Human No 6.6 EC50 = 260 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
425 4 1 3 4.1 C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5Cl
CHEMBL1624037 acm1_human Human No 5.6 EC50 = 2600 Funct
Agonist activity at human muscarinic M1 receptor by calcium mobilization assayAgonist activity at human muscarinic M1 receptor by calcium mobilization assay
333 7 2 4 2.0 CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C
CHEMBL486758 acm1_human Human No 5.6 EC50 = 2600 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
459 4 1 6 2.8 C1CN(CCC1N2C3=C(C(=CC=C3)F)NC2=O)C4CCN(CC4)S(=O)(=O)C5=CC=CC=C5
CHEMBL1916234 acm1_rat Rat No 5.6 EC50 = 2600 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
394 5 1 4 3.2 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC=CC=C3Cl
CHEMBL3823130 acm1_human Human No 5.6 EC50 = 2600 Funct
Positive allosteric modulation at human muscarinic acetylcholine receptor M1 assessed as effect on beta-arrestin recruitmentPositive allosteric modulation at human muscarinic acetylcholine receptor M1 assessed as effect on beta-arrestin recruitment
322 3 0 4 1.5 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3CC4=C(C3=O)C=CC=N4)F
CHEMBL1624037 acm1_human Human No 5.6 EC50 = 2600 Funct
Agonist activity at human muscarinic M1 receptor by calcium mobilization assayAgonist activity at human muscarinic M1 receptor by calcium mobilization assay
333 7 2 4 2.0 CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C
CHEMBL486758 acm1_human Human No 5.6 EC50 = 2600 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
459 4 1 6 2.8 C1CN(CCC1N2C3=C(C(=CC=C3)F)NC2=O)C4CCN(CC4)S(=O)(=O)C5=CC=CC=C5
CHEMBL1916234 acm1_rat Rat No 5.6 EC50 = 2600 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
394 5 1 4 3.2 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC=CC=C3Cl
CHEMBL3823130 acm1_human Human No 5.6 EC50 = 2600 Funct
Positive allosteric modulation at human muscarinic acetylcholine receptor M1 assessed as effect on beta-arrestin recruitmentPositive allosteric modulation at human muscarinic acetylcholine receptor M1 assessed as effect on beta-arrestin recruitment
322 3 0 4 1.5 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3CC4=C(C3=O)C=CC=N4)F
CHEMBL2333478 acm1_human Human No 5.6 EC50 = 2630.3 Funct
Positive allosteric modulation of human muscarinic M1 receptorPositive allosteric modulation of human muscarinic M1 receptor
463 4 0 5 3.9 CN1C=C(C=N1)C2=CC(=C(C(=C2)F)CN3C4=CC=CC=C4C5(C3=O)CCN(C5)C6CCCC6)F
CHEMBL1243232 acm1_human Human No 7.6 EC50 = 27 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
345 6 1 4 1.8 CCC(=O)NC1CCN(CC1)CCCN2C(=O)COC3=CC=CC=C32
CHEMBL1243232 acm1_human Human No 7.6 EC50 = 27 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
345 6 1 4 1.8 CCC(=O)NC1CCN(CC1)CCCN2C(=O)COC3=CC=CC=C32
CHEMBL596508 acm1_human Human No 6.6 EC50 = 270 Funct
Positive allosteric modulation activity at muscarinic M1 receptorPositive allosteric modulation activity at muscarinic M1 receptor
391 4 1 6 5.3 C1=CC=C(C=C1)C2=CC=C(C=C2)CN3C=C(C(=O)C4=C(C=CC(=C43)F)F)C(=O)O
CHEMBL596508 acm1_human Human No 6.6 EC50 = 270 Funct
Positive allosteric modulation activity at muscarinic M1 receptorPositive allosteric modulation activity at muscarinic M1 receptor
391 4 1 6 5.3 C1=CC=C(C=C1)C2=CC=C(C=C2)CN3C=C(C(=O)C4=C(C=CC(=C43)F)F)C(=O)O
CHEMBL167438 acm1_human Human No 4.6 EC50 = 27000 Funct
Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholine receptor M1Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholine receptor M1
168 3 0 3 1.5 CCCON=C1CN2CCC1C2
CHEMBL7303 acm1_mouse Mouse Yes 4.6 EC50 = 27000 Funct
Tested against Muscarinic acetylcholine receptor M1 expressed in A9 L cell lineTested against Muscarinic acetylcholine receptor M1 expressed in A9 L cell line
155 2 0 3 0.3 CN1CCC=C(C1)C(=O)OC
CHEMBL471635 acm1_human Human No 5.6 EC50 = 2710 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
453 3 1 3 4.0 CC1=CC=CC=C1C(=O)N2CCC(CC2)N3CCC(CC3)N4C5=C(C=C(C=C5)Cl)NC4=O
CHEMBL471635 acm1_human Human No 5.6 EC50 = 2710 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
453 3 1 3 4.0 CC1=CC=CC=C1C(=O)N2CCC(CC2)N3CCC(CC3)N4C5=C(C=C(C=C5)Cl)NC4=O
CHEMBL3747037 acm1_human Human No 6.6 EC50 = 273 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
493 6 2 5 3.1 C1CCC(C(C1)NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)N5C=C(C=N5)C6=CC=NC=C6)O
CHEMBL3747037 acm1_human Human No 6.6 EC50 = 273 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
493 6 2 5 3.1 C1CCC(C(C1)NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)N5C=C(C=N5)C6=CC=NC=C6)O
CHEMBL3824114 acm1_rat Rat No 5.6 EC50 = 2754.2 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
403 3 0 6 3.1 CN1C=C2C=C(C=CC2=N1)C3=CC(=C(C(=C3)F)CN4C5=C(N=CC=C5)N=CC4=O)F
CHEMBL319109 acm1_human Human No 7.6 EC50 = 28.3 Funct
Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptorStimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptor
325 4 0 5 3.2 C1CC2CN(C1)CC2C3=NSN=C3OCC#CC4=CC=CC=C4
CHEMBL3608414 acm1_human Human No 7.5 EC50 = 28.5 Funct
Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
449 5 2 6 1.4 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5CCOCC5O)F
CHEMBL3608414 acm1_human Human No 7.6 EC50 = 28.5 Funct
Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
449 5 2 6 1.4 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5CCOCC5O)F
CHEMBL3824114 acm1_rat Rat No 5.6 EC50 = 2800 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
403 3 0 6 3.1 CN1C=C2C=C(C=CC2=N1)C3=CC(=C(C(=C3)F)CN4C5=C(N=CC=C5)N=CC4=O)F
CHEMBL3824114 acm1_rat Rat No 5.6 EC50 = 2800 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
403 3 0 6 3.1 CN1C=C2C=C(C=CC2=N1)C3=CC(=C(C(=C3)F)CN4C5=C(N=CC=C5)N=CC4=O)F
CHEMBL1243074 acm1_human Human No 6.5 EC50 = 290 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
424 7 1 4 3.2 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C(=O)CCC4=C3C(=CC=C4)F
CHEMBL1243074 acm1_human Human No 6.5 EC50 = 290 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
424 7 1 4 3.2 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C(=O)CCC4=C3C(=CC=C4)F
CHEMBL335542 acm1_human Human No 6.5 EC50 = 290 Funct
Agonistic activity against M1 muscarinic receptor expressed in NIH 3T3 cellsAgonistic activity against M1 muscarinic receptor expressed in NIH 3T3 cells
553 16 0 13 1.2 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOC3=NSN=C3C4=CCCN(C4)C
CHEMBL3745724 acm1_human Human No 6.5 EC50 = 293 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
446 5 2 5 1.7 CC1=NC2=C(C=C1)N(C=C2C(=O)NC3CCOCC3O)CC4=CC=C(C=C4)C5=NN(C=C5)C
CHEMBL3745724 acm1_human Human No 6.5 EC50 = 293 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
446 5 2 5 1.7 CC1=NC2=C(C=C1)N(C=C2C(=O)NC3CCOCC3O)CC4=CC=C(C=C4)C5=NN(C=C5)C
CHEMBL3354075 acm1_human Human No 6.5 EC50 = 295.1 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assay
415 13 1 3 5.7 C1CN(CCC1CCCCCCCCCO)CCCN2C(=O)CCC3=CC=CC=C32
CHEMBL3354075 acm1_human Human No 6.5 EC50 = 295.1 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assay
415 13 1 3 5.7 C1CN(CCC1CCCCCCCCCO)CCCN2C(=O)CCC3=CC=CC=C32
CHEMBL1083618 acm1_human Human No 8.5 EC50 = 3.2 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
345 4 2 3 3.2 C1CNCC=C1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL1083618 acm1_human Human No 8.5 EC50 = 3.2 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
345 4 2 3 3.2 C1CNCC=C1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL1223863 acm1_human Human No 8.5 EC50 = 3.2 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
383 4 0 5 3.4 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)C#N)OC3=O
CHEMBL1223805 acm1_human Human No 8.5 EC50 = 3.2 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
357 3 0 3 3.3 CC1=CC2=C(CC(=O)N2C3CCN(CC3)C4(CCC(CC4)OC)C)C=C1
CHEMBL1223863 acm1_human Human No 8.5 EC50 = 3.2 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
383 4 0 5 3.4 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)C#N)OC3=O
CHEMBL1223805 acm1_human Human No 8.5 EC50 = 3.2 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
357 3 0 3 3.3 CC1=CC2=C(CC(=O)N2C3CCN(CC3)C4(CCC(CC4)OC)C)C=C1
CHEMBL3608417 acm1_human Human No 7.5 EC50 = 30.3 Funct
Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
449 5 2 6 1.4 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5COCCC5O)F
CHEMBL3608417 acm1_human Human No 7.5 EC50 = 30.3 Funct
Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
449 5 2 6 1.4 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5COCCC5O)F
CHEMBL2059320 acm1_human Human No 6.5 EC50 = 300 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
423 5 1 4 2.8 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCN4C(=O)CCC5=C4C(=CC=C5)F
CHEMBL2059320 acm1_human Human No 6.5 EC50 = 300 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
423 5 1 4 2.8 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCN4C(=O)CCC5=C4C(=CC=C5)F
CHEMBL2333473 acm1_human Human No 5.5 EC50 = 3020.0 Funct
Positive allosteric modulation of human muscarinic M1 receptorPositive allosteric modulation of human muscarinic M1 receptor
459 4 0 4 4.2 CC1=NN(C=C1C2=CC(=C(C=C2)CN3C4=CC=CC=C4C5(C3=O)CCN(C5)C6CCCC6)F)C
CHEMBL1773115 acm1_rat Rat No 5.5 EC50 = 3070 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
494 7 2 7 3.5 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=C(C=CC(=C4)C5=CNN=C5)F
CHEMBL1773115 acm1_rat Rat No 5.5 EC50 = 3070 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
494 7 2 7 3.5 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=C(C=CC(=C4)C5=CNN=C5)F
CHEMBL2333871 acm1_human Human No 5.5 EC50 = 3090.3 Funct
Positive allosteric modulation of human muscarinic M1 receptorPositive allosteric modulation of human muscarinic M1 receptor
445 4 0 4 3.8 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=CC=CC=C4C5(C3=O)CCN(C5)C6CCCC6)F
CHEMBL3402921 acm1_human Human No 7.5 EC50 = 31 Funct
Agonist activity at human m1 muscarinic acetylcholine receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human m1 muscarinic acetylcholine receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
249 2 0 4 0.3 CN1CCC=C(C1)C2=NOC(C2)N3CCCC3=O
CHEMBL3618450 acm1_human Human No 7.5 EC50 = 31 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
466 6 2 4 4.0 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)Cl)O)C=C1)N(C)CC4=CC=C(C=C4)F
CHEMBL3402921 acm1_human Human No 7.5 EC50 = 31 Funct
Agonist activity at human m1 muscarinic acetylcholine receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human m1 muscarinic acetylcholine receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
249 2 0 4 0.3 CN1CCC=C(C1)C2=NOC(C2)N3CCCC3=O
CHEMBL3618450 acm1_human Human No 7.5 EC50 = 31 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
466 6 2 4 4.0 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)Cl)O)C=C1)N(C)CC4=CC=C(C=C4)F
CHEMBL1083404 acm1_human Human No 7.5 EC50 = 31.6 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
381 4 2 3 4.5 C1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=C(C=CC(=C3)Cl)Cl
CHEMBL1083404 acm1_human Human No 7.5 EC50 = 31.6 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
381 4 2 3 4.5 C1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=C(C=CC(=C3)Cl)Cl
CHEMBL594432 acm1_human Human No 7.5 EC50 = 31.6 Funct
Allosteric modulation of human muscarinic M1 acetylcholine receptor expressed CHO cells assessed as intracellular calcium mobilization after 1 hr by Fluo-4-AM based fluorescence assayAllosteric modulation of human muscarinic M1 acetylcholine receptor expressed CHO cells assessed as intracellular calcium mobilization after 1 hr by Fluo-4-AM based fluorescence assay
345 4 1 7 3.6 COC1=CC=C(C=C1)CN2C=C(C(=O)C3=C(C=CC(=C32)F)F)C(=O)O
CHEMBL1243386 acm1_human Human No 6.5 EC50 = 310 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
361 6 1 4 2.1 CCC(=O)NC1CCN(CC1)CCCN2C(=O)CCC3=C2C(=CC=C3)F
CHEMBL1916229 acm1_rat Rat No 6.5 EC50 = 310 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
395 5 1 6 2.8 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC(=C(C=C3)F)F
CHEMBL1243386 acm1_human Human No 6.5 EC50 = 310 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
361 6 1 4 2.1 CCC(=O)NC1CCN(CC1)CCCN2C(=O)CCC3=C2C(=CC=C3)F
CHEMBL1916229 acm1_rat Rat No 6.5 EC50 = 310 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
395 5 1 6 2.8 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CC(=C(C=C3)F)F
CHEMBL3290084 acm1_human Human No 6.5 EC50 = 316.2 Funct
Activation of human M1 mAChR expressed in FlpIn-CHO cells assessed as FBS-induced ERK1/2 phosphorylation incubated for 5 mins by Alphascreen assayActivation of human M1 mAChR expressed in FlpIn-CHO cells assessed as FBS-induced ERK1/2 phosphorylation incubated for 5 mins by Alphascreen assay
361 4 1 7 3.3 C1=CC=C2C(=C1)C(=O)C(=CN2CC3=CC=C(C=C3)S(=O)(=O)F)C(=O)O
CHEMBL3290084 acm1_human Human No 6.5 EC50 = 316.2 Funct
Activation of human M1 mAChR expressed in FlpIn-CHO cells assessed as FBS-induced ERK1/2 phosphorylation incubated for 5 mins by Alphascreen assayActivation of human M1 mAChR expressed in FlpIn-CHO cells assessed as FBS-induced ERK1/2 phosphorylation incubated for 5 mins by Alphascreen assay
361 4 1 7 3.3 C1=CC=C2C(=C1)C(=O)C(=CN2CC3=CC=C(C=C3)S(=O)(=O)F)C(=O)O
CHEMBL376295 acm1_human Human No 5.5 EC50 = 3162.3 Funct
Agonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
468 16 0 12 2.8 COC1=NSN=C1OCCCOCCCOCCCOC2=NSN=C2C3=CN=CC=C3
CHEMBL1086298 acm1_human Human No 5.5 EC50 = 3162.3 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
343 5 2 2 4.1 C1CNCCC1CCNC(=O)C2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL376295 acm1_human Human No 5.5 EC50 = 3162.3 Funct
Agonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
468 16 0 12 2.8 COC1=NSN=C1OCCCOCCCOCCCOC2=NSN=C2C3=CN=CC=C3
CHEMBL1086298 acm1_human Human No 5.5 EC50 = 3162.3 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
343 5 2 2 4.1 C1CNCCC1CCNC(=O)C2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL2024405 acm1_human Human No 6.5 EC50 = 320 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
371 5 1 4 2.9 CCOC(=O)N1C2CCC1CC(C2)N3CCC(C3)NC(=O)C4=CC=CC=C4
CHEMBL2024405 acm1_human Human No 6.5 EC50 = 320 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
371 5 1 4 2.9 CCOC(=O)N1C2CCC1CC(C2)N3CCC(C3)NC(=O)C4=CC=CC=C4
CHEMBL503735 acm1_rat Rat Yes 5.5 EC50 = 3200 Funct
Activation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
340 2 0 5 3.9 C1=CC2=C(C(=C1)Cl)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL503735 acm1_rat Rat Yes 5.5 EC50 = 3200 Funct
Agonist activity at rat muscarinic M1 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at rat muscarinic M1 expressed in CHO cells assessed as stimulation of calcium mobilization
340 2 0 5 3.9 C1=CC2=C(C(=C1)Cl)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL3823130 acm1_rat Rat No 5.5 EC50 = 3200 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
322 3 0 4 1.5 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3CC4=C(C3=O)C=CC=N4)F
CHEMBL503735 acm1_rat Rat Yes 5.5 EC50 = 3200 Funct
Activation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
340 2 0 5 3.9 C1=CC2=C(C(=C1)Cl)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL503735 acm1_rat Rat Yes 5.5 EC50 = 3200 Funct
Agonist activity at rat muscarinic M1 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at rat muscarinic M1 expressed in CHO cells assessed as stimulation of calcium mobilization
340 2 0 5 3.9 C1=CC2=C(C(=C1)Cl)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL7303 acm1_human Human Yes 5.5 EC50 = 3200 Funct
In Vitro evaluation activity at the cloned Human Muscarinic acetylcholine receptor M1 determined by receptor selection and amplification technology (R-SAT)In Vitro evaluation activity at the cloned Human Muscarinic acetylcholine receptor M1 determined by receptor selection and amplification technology (R-SAT)
155 2 0 3 0.3 CN1CCC=C(C1)C(=O)OC
CHEMBL2333875 acm1_human Human Yes 5.5 EC50 = 3200 Funct
Positive allosteric modulation at muscarinic acetylcholine receptor M1(unknown origin)Positive allosteric modulation at muscarinic acetylcholine receptor M1(unknown origin)
379 3 0 5 2.0 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=CC=CC=C4C5(C3=O)OCCO5)F
CHEMBL3823130 acm1_rat Rat No 5.5 EC50 = 3200 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
322 3 0 4 1.5 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3CC4=C(C3=O)C=CC=N4)F
CHEMBL2333865 acm1_human Human Yes 5.5 EC50 = 3200 Funct
Positive allosteric modulation of human muscarinic M1 receptorPositive allosteric modulation of human muscarinic M1 receptor
390 3 0 4 2.5 CN1CCC2(C1)C3=CC=CC=C3N(C2=O)CC4=C(C=C(C=C4)C5=CN(N=C5)C)F
CHEMBL2313515 acm1_human Human No 5.5 EC50 = 3200 Funct
Positive allosteric modulator activity at human muscarinic M1 receptor by calcium mobilization assayPositive allosteric modulator activity at human muscarinic M1 receptor by calcium mobilization assay
353 3 0 4 3.1 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C(=O)CSC4=CC=CC=C43)F
CHEMBL1773099 acm1_rat Rat No 5.5 EC50 = 3210 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
490 7 1 6 3.4 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC=CC(=C4)C5=CN(N=C5)C
CHEMBL1773099 acm1_rat Rat No 5.5 EC50 = 3210 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
490 7 1 6 3.4 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC=CC(=C4)C5=CN(N=C5)C
CHEMBL2333482 acm1_human Human No 5.5 EC50 = 3235.9 Funct
Positive allosteric modulation of human muscarinic M1 receptorPositive allosteric modulation of human muscarinic M1 receptor
404 4 0 4 2.9 CCN1CCC2(C1)C3=CC=CC=C3N(C2=O)CC4=C(C=C(C=C4)C5=CN(N=C5)C)F
CHEMBL485953 acm1_human Human No 5.5 EC50 = 3300 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
459 4 1 6 2.8 C1CN(CCC1N2C3=C(C=CC(=C3)F)NC2=O)C4CCN(CC4)S(=O)(=O)C5=CC=CC=C5
CHEMBL485953 acm1_human Human No 5.5 EC50 = 3300 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
459 4 1 6 2.8 C1CN(CCC1N2C3=C(C=CC(=C3)F)NC2=O)C4CCN(CC4)S(=O)(=O)C5=CC=CC=C5
CHEMBL84893 acm1_human Human No 5.5 EC50 = 3300 Funct
Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholine receptor M1Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholine receptor M1
240 3 0 3 2.5 C1CN2CC1C(=NOCC#CC3=CC=CC=C3)C2
CHEMBL2313499 acm1_human Human No 5.5 EC50 = 3300 Funct
Positive allosteric modulator activity at human muscarinic M1 receptor by calcium mobilization assayPositive allosteric modulator activity at human muscarinic M1 receptor by calcium mobilization assay
419 4 1 7 3.2 CCN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=CC=CC=C4C(C3=O)(C(F)(F)F)O)F
CHEMBL2313498 acm1_human Human No 5.5 EC50 = 3300 Funct
Positive allosteric modulator activity at human muscarinic M1 receptor by calcium mobilization assayPositive allosteric modulator activity at human muscarinic M1 receptor by calcium mobilization assay
405 3 1 7 2.9 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=CC=CC=C4C(C3=O)(C(F)(F)F)O)F
CHEMBL478662 acm1_human Human No 6.5 EC50 = 334 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
459 4 1 6 4.3 C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5C(F)(F)F
CHEMBL478662 acm1_human Human No 6.5 EC50 = 334 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
459 4 1 6 4.3 C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5C(F)(F)F
CHEMBL3608413 acm1_rat Rat No 7.5 EC50 = 34.6 Funct
Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
448 5 2 5 2.6 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5CCCCC5O)F
CHEMBL3608413 acm1_rat Rat No 7.5 EC50 = 34.6 Funct
Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
448 5 2 5 2.6 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5CCCCC5O)F
CHEMBL3608420 acm1_human Human No 7.5 EC50 = 34.8 Funct
Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
432 5 2 6 0.2 CN1C=C(C=N1)C2=NC=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5COCCC5O
CHEMBL3608420 acm1_human Human No 7.5 EC50 = 34.8 Funct
Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
432 5 2 6 0.2 CN1C=C(C=N1)C2=NC=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5COCCC5O
CHEMBL142538 acm1_human Human No 6.5 EC50 = 340 Funct
Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.
561 17 0 10 6.3 CN1CCC=C(C1)C2=NSN=C2OCCCCCCCCCCCCOC3=NSN=C3C4=CCCN(C4)C
CHEMBL1565295 acm1_rat Rat No 5.5 EC50 = 3449 Funct
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]
490 7 1 6 3.4 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC=CC(=C4)C5=NN(C=C5)C
CHEMBL1565295 acm1_rat Rat No 5.5 EC50 = 3449 Funct
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]
490 7 1 6 3.4 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC=CC(=C4)C5=NN(C=C5)C
CHEMBL2024332 acm1_human Human No 6.5 EC50 = 350 Funct
Agonist activity at human muscarinic M1 receptor by calcium mobilization assayAgonist activity at human muscarinic M1 receptor by calcium mobilization assay
386 5 1 4 3.2 CCOC(=O)N1C2CCC1CC(C2)N3CCCC(C3)NC(=O)C4=CC=CC=C4
CHEMBL1243296 acm1_human Human No 6.5 EC50 = 350 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
386 6 1 4 2.9 C1CCC(C1)C(=O)NC2CCN(CC2)CCCN3C(=O)COC4=CC=CC=C43
CHEMBL2024332 acm1_human Human No 6.5 EC50 = 350 Funct
Agonist activity at human muscarinic M1 receptor by calcium mobilization assayAgonist activity at human muscarinic M1 receptor by calcium mobilization assay
386 5 1 4 3.2 CCOC(=O)N1C2CCC1CC(C2)N3CCCC(C3)NC(=O)C4=CC=CC=C4
CHEMBL1243296 acm1_human Human No 6.5 EC50 = 350 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
386 6 1 4 2.9 C1CCC(C1)C(=O)NC2CCN(CC2)CCCN3C(=O)COC4=CC=CC=C43
CHEMBL337131 acm1_human Human No 6.5 EC50 = 350 Funct
Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.
467 8 0 10 3.0 CN1CCC=C(C1)C2=NSN=C2SCCCSC3=NSN=C3C4=CCCN(C4)C
CHEMBL3289440 acm1_human Human No 6.5 EC50 = 352 Funct
Agonist activity at human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as calcium mobilization by FLIPR assayAgonist activity at human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as calcium mobilization by FLIPR assay
437 5 0 7 1.7 CCOC(=O)N1CCC(CC1)CN2CCC3(CC2)CN(C4=C3C=CC=N4)S(=O)(=O)C
CHEMBL3289440 acm1_human Human No 6.5 EC50 = 352 Funct
Agonist activity at human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as calcium mobilization by FLIPR assayAgonist activity at human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as calcium mobilization by FLIPR assay
437 5 0 7 1.7 CCOC(=O)N1CCC(CC1)CN2CCC3(CC2)CN(C4=C3C=CC=N4)S(=O)(=O)C
CHEMBL490597 acm1_human Human No 6.5 EC50 = 356 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
425 4 1 3 4.1 C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5
CHEMBL490597 acm1_human Human No 6.5 EC50 = 356 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
425 4 1 3 4.1 C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5
CHEMBL3616500 acm1_human Human No 7.4 EC50 = 36 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
500 6 2 7 4.3 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)C(F)(F)F)O)C=C1)N(C)CC4=CC=C(C=C4)F
CHEMBL3616500 acm1_human Human No 7.4 EC50 = 36 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
500 6 2 7 4.3 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)C(F)(F)F)O)C=C1)N(C)CC4=CC=C(C=C4)F
CHEMBL2024422 acm1_human Human No 5.4 EC50 = 3600 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
375 8 2 5 2.2 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC(=CC=C3)OC
CHEMBL3084454 acm1_human Human No 5.4 EC50 = 3600 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
337 7 2 4 1.8 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3CCCC3
CHEMBL487986 acm1_human Human No 5.4 EC50 = 3600 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
554 4 2 7 5.1 C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)C4CCN(CC4)C(=O)NC5=CC(=CC=C5)SC(F)(F)F
CHEMBL2024422 acm1_human Human No 5.4 EC50 = 3600 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
375 8 2 5 2.2 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC(=CC=C3)OC
CHEMBL3084454 acm1_human Human No 5.4 EC50 = 3600 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
337 7 2 4 1.8 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3CCCC3
CHEMBL487986 acm1_human Human No 5.4 EC50 = 3600 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
554 4 2 7 5.1 C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)C4CCN(CC4)C(=O)NC5=CC(=CC=C5)SC(F)(F)F
CHEMBL3360945 acm1_human Human No 5.4 EC50 = 3630.8 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
394 4 0 4 4.1 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CN=CC=C5)C
CHEMBL3360945 acm1_human Human No 5.4 EC50 = 3630.8 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
394 4 0 4 4.1 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CN=CC=C5)C
CHEMBL3360945 acm1_human Human No 5.4 EC50 = 3660 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
394 4 0 4 4.1 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CN=CC=C5)C
CHEMBL3745962 acm1_human Human No 6.4 EC50 = 371 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
428 5 2 5 2.4 C1CCC(C(C1)NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)C5=CN=CN=C5)O
CHEMBL3745962 acm1_human Human No 6.4 EC50 = 371 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
428 5 2 5 2.4 C1CCC(C(C1)NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)C5=CN=CN=C5)O
CHEMBL1773272 acm1_rat Rat Yes 5.4 EC50 = 3790 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
488 6 1 5 4.2 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC(=CC=C4)Br
CHEMBL3360944 acm1_human Human No 5.4 EC50 = 3790 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
394 4 0 4 4.1 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC=CC=N5)C
CHEMBL1773272 acm1_rat Rat Yes 5.4 EC50 = 3790 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
488 6 1 5 4.2 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC(=CC=C4)Br
CHEMBL596506 acm1_human Human No 6.4 EC50 = 380 Funct
Positive allosteric modulation activity at muscarinic M1 receptorPositive allosteric modulation activity at muscarinic M1 receptor
373 4 1 5 5.2 C1=CC=C(C=C1)C2=CC=C(C=C2)CN3C=C(C(=O)C4=C3C(=CC=C4)F)C(=O)O
CHEMBL596506 acm1_human Human No 6.4 EC50 = 380 Funct
Positive allosteric modulation activity at muscarinic M1 receptorPositive allosteric modulation activity at muscarinic M1 receptor
373 4 1 5 5.2 C1=CC=C(C=C1)C2=CC=C(C=C2)CN3C=C(C(=O)C4=C3C(=CC=C4)F)C(=O)O
CHEMBL2333865 acm1_human Human Yes 5.4 EC50 = 3800 Funct
Positive allosteric modulation at muscarinic acetylcholine receptor M1(unknown origin)Positive allosteric modulation at muscarinic acetylcholine receptor M1(unknown origin)
390 3 0 4 2.5 CN1CCC2(C1)C3=CC=CC=C3N(C2=O)CC4=C(C=C(C=C4)C5=CN(N=C5)C)F
CHEMBL2333868 acm1_human Human No 5.4 EC50 = 3800 Funct
Positive allosteric modulation of human muscarinic M1 receptorPositive allosteric modulation of human muscarinic M1 receptor
404 3 0 4 2.9 CN1CCC2(CC1)C3=CC=CC=C3N(C2=O)CC4=C(C=C(C=C4)C5=CN(N=C5)C)F
CHEMBL3360944 acm1_human Human No 5.4 EC50 = 3801.9 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
394 4 0 4 4.1 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC=CC=N5)C
CHEMBL3360944 acm1_human Human No 5.4 EC50 = 3801.9 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
394 4 0 4 4.1 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC=CC=N5)C
CHEMBL3290087 acm1_human Human No 6.4 EC50 = 389.1 Funct
Activation of human M1 mAChR expressed in FlpIn-CHO cells assessed as FBS-induced ERK1/2 phosphorylation incubated for 5 mins by Alphascreen assayActivation of human M1 mAChR expressed in FlpIn-CHO cells assessed as FBS-induced ERK1/2 phosphorylation incubated for 5 mins by Alphascreen assay
336 4 1 6 4.9 C1=CC=C2C(=C1)C(=O)C(=CN2CC3=CC=C(C=C3)N=C=S)C(=O)O
CHEMBL3290087 acm1_human Human No 6.4 EC50 = 389.1 Funct
Activation of human M1 mAChR expressed in FlpIn-CHO cells assessed as FBS-induced ERK1/2 phosphorylation incubated for 5 mins by Alphascreen assayActivation of human M1 mAChR expressed in FlpIn-CHO cells assessed as FBS-induced ERK1/2 phosphorylation incubated for 5 mins by Alphascreen assay
336 4 1 6 4.9 C1=CC=C2C(=C1)C(=O)C(=CN2CC3=CC=C(C=C3)N=C=S)C(=O)O
CHEMBL1083002 acm1_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
375 5 2 3 4.7 CCC1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL1083109 acm1_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
363 4 2 2 4.6 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=C(C=CC(=C3)Cl)Cl
CHEMBL1083002 acm1_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
375 5 2 3 4.7 CCC1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL1083109 acm1_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
363 4 2 2 4.6 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=C(C=CC(=C3)Cl)Cl
CHEMBL3618449 acm1_human Human No 6.4 EC50 = 392 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
450 6 2 5 3.5 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)F)O)C=C1)N(C)CC4=CC=C(C=C4)F
CHEMBL3618449 acm1_human Human No 6.4 EC50 = 392 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
450 6 2 5 3.5 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)F)O)C=C1)N(C)CC4=CC=C(C=C4)F
CHEMBL1086479 acm1_human Human No 6.4 EC50 = 398.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
357 5 1 2 3.8 CC(=O)N(CC1CCNCC1)CC2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL1802360 acm1_human Human Yes 6.4 EC50 = 398.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
369 6 1 4 4.1 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCOC4=CC=C(C=C4)F
CHEMBL1086479 acm1_human Human No 6.4 EC50 = 398.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
357 5 1 2 3.8 CC(=O)N(CC1CCNCC1)CC2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL1802360 acm1_human Human Yes 6.4 EC50 = 398.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
369 6 1 4 4.1 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCOC4=CC=C(C=C4)F
CHEMBL136027 acm1_human Human No 6.4 EC50 = 398.1 Funct
Effective concentration was evaluated against Muscarinic acetylcholine receptor M1 expressed in A9 L cellsEffective concentration was evaluated against Muscarinic acetylcholine receptor M1 expressed in A9 L cells
496 17 0 10 6.3 CN1CCC=C(C1)C2=NSN=C2OCCCCCCCCCCCCOC3=NSN=C3OC
CHEMBL468925 acm1_rat Rat Yes 5.4 EC50 = 3990 Funct
Activation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
334 2 0 3 3.2 C1=CC2=C(C(=C1)F)N(C(=O)C2=O)CC3=CC=C(C=C3)Br
CHEMBL468925 acm1_rat Rat Yes 5.4 EC50 = 3990 Funct
Activation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
334 2 0 3 3.2 C1=CC2=C(C(=C1)F)N(C(=O)C2=O)CC3=CC=C(C=C3)Br
CHEMBL418491 acm1_human Human No 8.4 EC50 = 4.5 Funct
Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.
343 4 0 6 3.2 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC=C(C=C5)F
CHEMBL304247 acm1_human Human No 8.3 EC50 = 4.9 Funct
Compound was tested for its ability to stimulate phosphoinositol (PI) hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1 (100 uM concentration)Compound was tested for its ability to stimulate phosphoinositol (PI) hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1 (100 uM concentration)
327 4 0 6 2.6 C1C2C3C2(CN1C3)C4=NSN=C4OCC#CC5=CC(=CC=C5)F
CHEMBL1802360 acm1_human Human Yes 6.4 EC50 = 400 Funct
Agonist activity at human M1 muscarinic receptor expressed in CHO cells assessed as inhibition of carbachol-stimulated phosphatidyl-inositol hydrolysis by cell-based functional assayAgonist activity at human M1 muscarinic receptor expressed in CHO cells assessed as inhibition of carbachol-stimulated phosphatidyl-inositol hydrolysis by cell-based functional assay
369 6 1 4 4.1 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCOC4=CC=C(C=C4)F
CHEMBL2059304 acm1_human Human Yes 6.4 EC50 = 400 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
337 5 1 3 3.6 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCOC4=CC=CC=C4
CHEMBL1802360 acm1_human Human Yes 6.4 EC50 = 400 Funct
Agonist activity at human M1 muscarinic receptor expressed in CHO cells assessed as inhibition of carbachol-stimulated phosphatidyl-inositol hydrolysis by cell-based functional assayAgonist activity at human M1 muscarinic receptor expressed in CHO cells assessed as inhibition of carbachol-stimulated phosphatidyl-inositol hydrolysis by cell-based functional assay
369 6 1 4 4.1 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCOC4=CC=C(C=C4)F
CHEMBL2059304 acm1_human Human Yes 6.4 EC50 = 400 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
337 5 1 3 3.6 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCOC4=CC=CC=C4
CHEMBL978 acm1_rat Rat Yes 6.4 EC50 = 400 Funct
Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M1Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M1
160 4 0 2 0.6 CC(C[N+](C)(C)C)OC(=O)C
CHEMBL2313507 acm1_human Human No 5.4 EC50 = 4000 Funct
Positive allosteric modulator activity at human muscarinic M1 receptor by calcium mobilization assayPositive allosteric modulator activity at human muscarinic M1 receptor by calcium mobilization assay
387 3 1 6 2.8 CN1C=C(C=N1)C2=CC=C(C=C2)CN3C4=CC=CC=C4C(C3=O)(C(F)(F)F)O
CHEMBL2333483 acm1_human Human No 5.4 EC50 = 4073.8 Funct
Positive allosteric modulation of human muscarinic M1 receptorPositive allosteric modulation of human muscarinic M1 receptor
422 5 0 5 2.9 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=CC=CC=C4C5(C3=O)CCN(C5)CCF)F
CHEMBL2333480 acm1_human Human No 5.4 EC50 = 4073.8 Funct
Positive allosteric modulation of human muscarinic M1 receptorPositive allosteric modulation of human muscarinic M1 receptor
463 4 0 5 3.9 CN1C=C(C=N1)C2=CC(=C(C=C2F)CN3C4=CC=CC=C4C5(C3=O)CCN(C5)C6CCCC6)F
CHEMBL2022960 acm1_human Human Yes 7.4 EC50 = 41 Funct
Agonist activity at human muscarinic M1 receptor by calcium mobilization assayAgonist activity at human muscarinic M1 receptor by calcium mobilization assay
348 7 0 4 4.5 CCCCC1CCN(CC1)CCCN2C(=O)COC3=C2C=CC(=C3)F
CHEMBL2063422 acm1_human Human No 7.4 EC50 = 41 Funct
Positive allosteric modulation activity at muscarinic M1 receptorPositive allosteric modulation activity at muscarinic M1 receptor
395 4 1 7 3.6 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C=C(C(=O)C4=C3C=CC=C4F)C(=O)O)F
CHEMBL2022960 acm1_human Human Yes 7.4 EC50 = 41 Funct
Agonist activity at human muscarinic M1 receptor by calcium mobilization assayAgonist activity at human muscarinic M1 receptor by calcium mobilization assay
348 7 0 4 4.5 CCCCC1CCN(CC1)CCCN2C(=O)COC3=C2C=CC(=C3)F
CHEMBL2063422 acm1_human Human No 7.4 EC50 = 41 Funct
Positive allosteric modulation activity at muscarinic M1 receptorPositive allosteric modulation activity at muscarinic M1 receptor
395 4 1 7 3.6 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C=C(C(=O)C4=C3C=CC=C4F)C(=O)O)F
CHEMBL3354068 acm1_human Human No 7.4 EC50 = 41.7 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assay
566 14 0 7 6.0 CN1CCC=C(C1)C2=NSN=C2OCCCCCCCC3CCN(CC3)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL3354068 acm1_human Human No 7.4 EC50 = 41.7 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assay
566 14 0 7 6.0 CN1CCC=C(C1)C2=NSN=C2OCCCCCCCC3CCN(CC3)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL478662 acm1_human Human No 6.4 EC50 = 410 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
459 4 1 6 4.3 C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5C(F)(F)F
CHEMBL478662 acm1_human Human No 6.4 EC50 = 410 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
459 4 1 6 4.3 C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5C(F)(F)F
CHEMBL521030 acm1_human Human No 5.4 EC50 = 4100 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
475 4 1 5 3.4 C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)C4CCN(CC4)S(=O)(=O)C5=CC=CC=C5
CHEMBL521030 acm1_human Human No 5.4 EC50 = 4100 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
475 4 1 5 3.4 C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)C4CCN(CC4)S(=O)(=O)C5=CC=CC=C5
CHEMBL3290085 acm1_human Human No 6.4 EC50 = 416.9 Funct
Activation of human M1 mAChR expressed in FlpIn-CHO cells assessed as FBS-induced ERK1/2 phosphorylation incubated for 5 mins by Alphascreen assayActivation of human M1 mAChR expressed in FlpIn-CHO cells assessed as FBS-induced ERK1/2 phosphorylation incubated for 5 mins by Alphascreen assay
374 4 1 6 2.6 C1=CC=C2C(=C1)C(=O)C(=CN2CC3=CC=C(C=C3)N4C(=O)C=CC4=O)C(=O)O
CHEMBL3290085 acm1_human Human No 6.4 EC50 = 416.9 Funct
Activation of human M1 mAChR expressed in FlpIn-CHO cells assessed as FBS-induced ERK1/2 phosphorylation incubated for 5 mins by Alphascreen assayActivation of human M1 mAChR expressed in FlpIn-CHO cells assessed as FBS-induced ERK1/2 phosphorylation incubated for 5 mins by Alphascreen assay
374 4 1 6 2.6 C1=CC=C2C(=C1)C(=O)C(=CN2CC3=CC=C(C=C3)N4C(=O)C=CC4=O)C(=O)O
CHEMBL3616497 acm1_human Human No 6.4 EC50 = 426 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
522 8 3 4 4.1 CC(=NCCC1=CC=C(C=C1)OC)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3616497 acm1_human Human No 6.4 EC50 = 426 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
522 8 3 4 4.1 CC(=NCCC1=CC=C(C=C1)OC)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3823474 acm1_rat Rat No 5.4 EC50 = 4265.8 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
404 3 0 5 3.4 CN1C=C2C(=N1)C=CC=C2C3=CC(=C(C(=C3)F)CN4CCC5=C(C4=O)C=CC=N5)F
CHEMBL337925 acm1_human Human No 6.4 EC50 = 430.9 Funct
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
285 5 0 6 3.0 CCCSC1=NSN=C1OC2CN3CCC2CC3
CHEMBL3823474 acm1_rat Rat No 5.4 EC50 = 4300 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
404 3 0 5 3.4 CN1C=C2C(=N1)C=CC=C2C3=CC(=C(C(=C3)F)CN4CCC5=C(C4=O)C=CC=N5)F
CHEMBL3823474 acm1_rat Rat No 5.4 EC50 = 4300 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
404 3 0 5 3.4 CN1C=C2C(=N1)C=CC=C2C3=CC(=C(C(=C3)F)CN4CCC5=C(C4=O)C=CC=N5)F
CHEMBL2059322 acm1_human Human No 7.4 EC50 = 44 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
424 5 1 5 3.7 C1CN(CCC1N2C3=C(C=CC(=C3)F)NC2=O)CCCN4C(=O)COC5=CC=CC=C54
CHEMBL2059322 acm1_human Human No 7.4 EC50 = 44 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
424 5 1 5 3.7 C1CN(CCC1N2C3=C(C=CC(=C3)F)NC2=O)CCCN4C(=O)COC5=CC=CC=C54
CHEMBL2024421 acm1_human Human No 6.4 EC50 = 440 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
380 7 2 4 2.8 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC(=CC=C3)Cl
CHEMBL2024421 acm1_human Human No 6.4 EC50 = 440 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
380 7 2 4 2.8 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC(=CC=C3)Cl
CHEMBL343055 acm1_human Human No 6.4 EC50 = 440 Funct
Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.
453 7 0 10 2.7 CN1CCC=C(C1)C2=NSN=C2SCCSC3=NSN=C3C4=CCCN(C4)C
CHEMBL487984 acm1_human Human No 5.4 EC50 = 4400 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
519 4 1 5 3.4 C1CN(CCC1N2C3=C(C=C(C=C3)Br)NC2=O)C4CCN(CC4)S(=O)(=O)C5=CC=CC=C5
CHEMBL1773114 acm1_rat Rat No 5.4 EC50 = 4400 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
494 7 2 7 3.5 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC=CC(=C4F)C5=CNN=C5
CHEMBL487984 acm1_human Human No 5.4 EC50 = 4400 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
519 4 1 5 3.4 C1CN(CCC1N2C3=C(C=C(C=C3)Br)NC2=O)C4CCN(CC4)S(=O)(=O)C5=CC=CC=C5
CHEMBL1773114 acm1_rat Rat No 5.4 EC50 = 4400 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
494 7 2 7 3.5 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC=CC(=C4F)C5=CNN=C5
CHEMBL20835 acm1_human Human Yes 5.4 EC50 = 4466 Funct
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
169 2 0 3 0.7 CC(=O)OC1CN2CCC1CC2
CHEMBL3746322 acm1_human Human No 5.4 EC50 = 4500 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
415 5 2 4 3.4 C1CCC(C(C1)NC(=O)C2=NN(C3=CC=CC=C32)CC4=CC=C(C=C4)N5C=CC=N5)O
CHEMBL3746322 acm1_human Human No 5.4 EC50 = 4500 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
415 5 2 4 3.4 C1CCC(C(C1)NC(=O)C2=NN(C3=CC=CC=C32)CC4=CC=C(C=C4)N5C=CC=N5)O
CHEMBL1243233 acm1_human Human No 7.3 EC50 = 46 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
359 6 1 4 2.4 CC(C)C(=O)NC1CCN(CC1)CCCN2C(=O)COC3=CC=CC=C32
CHEMBL1243233 acm1_human Human No 7.3 EC50 = 46 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
359 6 1 4 2.4 CC(C)C(=O)NC1CCN(CC1)CCCN2C(=O)COC3=CC=CC=C32
CHEMBL60331 acm1_human Human No 7.3 EC50 = 46 Funct
Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.
378 4 0 6 3.8 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC(=CC(=C5)Cl)F
CHEMBL304142 acm1_human Human Yes 6.3 EC50 = 460 Funct
In Vitro evaluation activity at the cloned Human Muscarinic acetylcholine receptor M1 determined by receptor selection and amplification technology (R-SAT)In Vitro evaluation activity at the cloned Human Muscarinic acetylcholine receptor M1 determined by receptor selection and amplification technology (R-SAT)
168 1 1 4 0.3 COC1=NOC2=C1CNCCC2
CHEMBL3084449 acm1_human Human No 7.3 EC50 = 47 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
380 7 2 4 2.5 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3=CC(=CC=C3)Cl
CHEMBL3084449 acm1_human Human No 7.3 EC50 = 47 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
380 7 2 4 2.5 CCOC(=O)N1CC2CCC(C1)C2NCCNC(=O)C3=CC(=CC=C3)Cl
CHEMBL3608416 acm1_human Human No 7.3 EC50 = 47.9 Funct
Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
464 5 2 6 1.5 CC1(COCCC1NC(=O)C2=CN(C3=C2N=CC=C3)CC4=C(C=C(C=C4)C5=CN(N=C5)C)F)O
CHEMBL3608416 acm1_human Human No 7.3 EC50 = 47.9 Funct
Positive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
464 5 2 6 1.5 CC1(COCCC1NC(=O)C2=CN(C3=C2N=CC=C3)CC4=C(C=C(C=C4)C5=CN(N=C5)C)F)O
CHEMBL3822763 acm1_rat Rat No 5.3 EC50 = 4700 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
402 3 0 5 3.9 CN1C=C2C(=N1)C=CC=C2C3=CC(=C(C(=C3)F)CN4C=NC5=CC=CC=C5C4=O)F
CHEMBL3823885 acm1_rat Rat No 5.3 EC50 = 4700 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
403 3 0 6 2.8 CN1C=C2C(=N1)C=CC=C2C3=CC(=C(C(=C3)F)CN4C=NC5=C(C4=O)C=CN=C5)F
CHEMBL313918 acm1_human Human No 5.3 EC50 = 4700 Funct
Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholine receptor M1Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholine receptor M1
202 2 0 3 1.4 C#CCC#CCON=C1CN2CCC1C2
CHEMBL1556989 acm1_human Human Yes 6.3 EC50 = 473 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
393 4 0 3 5.1 CC1=CC(=C(C=C1)C)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC=CC=C5
CHEMBL1556989 acm1_human Human Yes 6.3 EC50 = 473 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
393 4 0 3 5.1 CC1=CC(=C(C=C1)C)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC=CC=C5
CHEMBL3745995 acm1_human Human No 6.3 EC50 = 478 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
374 4 2 4 2.3 C1CCC(C(C1)NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)C#N)O
CHEMBL3745995 acm1_human Human No 6.3 EC50 = 478 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
374 4 2 4 2.3 C1CCC(C(C1)NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)C#N)O
CHEMBL3822763 acm1_rat Rat No 5.3 EC50 = 4786.3 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
402 3 0 5 3.9 CN1C=C2C(=N1)C=CC=C2C3=CC(=C(C(=C3)F)CN4C=NC5=CC=CC=C5C4=O)F
CHEMBL3823885 acm1_rat Rat No 5.3 EC50 = 4786.3 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
403 3 0 6 2.8 CN1C=C2C(=N1)C=CC=C2C3=CC(=C(C(=C3)F)CN4C=NC5=C(C4=O)C=CN=C5)F
CHEMBL3822763 acm1_rat Rat No 5.3 EC50 = 4786.3 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
402 3 0 5 3.9 CN1C=C2C(=N1)C=CC=C2C3=CC(=C(C(=C3)F)CN4C=NC5=CC=CC=C5C4=O)F
CHEMBL3823885 acm1_rat Rat No 5.3 EC50 = 4786.3 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
403 3 0 6 2.8 CN1C=C2C(=N1)C=CC=C2C3=CC(=C(C(=C3)F)CN4C=NC5=C(C4=O)C=CN=C5)F
CHEMBL1243110 acm1_human Human No 7.3 EC50 = 48 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
406 7 1 3 3.1 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C(=O)CCC4=CC=CC=C43
CHEMBL1243110 acm1_human Human No 7.3 EC50 = 48 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
406 7 1 3 3.1 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C(=O)CCC4=CC=CC=C43
CHEMBL3618444 acm1_human Human No 7.3 EC50 = 48.4 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
496 6 3 4 3.9 CC(=NCC1=CC(=CC=C1)F)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3618444 acm1_human Human No 7.3 EC50 = 48.4 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
496 6 3 4 3.9 CC(=NCC1=CC(=CC=C1)F)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL129474 acm1_human Human No 5.3 EC50 = 4867 Funct
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
243 6 1 6 2.0 CCCCOC1=NSN=C1OC2CCNC2
CHEMBL3823059 acm1_rat Rat No 5.3 EC50 = 4897.8 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
402 3 0 5 3.9 CN1C=C2C(=N1)C=CC=C2C3=CC(=C(C(=C3)F)CN4C5=CC=CC=C5N=CC4=O)F
CHEMBL3823059 acm1_rat Rat No 5.3 EC50 = 4897.8 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
402 3 0 5 3.9 CN1C=C2C(=N1)C=CC=C2C3=CC(=C(C(=C3)F)CN4C5=CC=CC=C5N=CC4=O)F
CHEMBL1243043 acm1_human Human No 7.3 EC50 = 49 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
424 7 1 4 3.2 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C(=O)CCC4=C3C=CC(=C4)F
CHEMBL1243043 acm1_human Human No 7.3 EC50 = 49 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
424 7 1 4 3.2 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C(=O)CCC4=C3C=CC(=C4)F
CHEMBL3616499 acm1_human Human No 7.3 EC50 = 49.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
446 6 2 4 3.7 CC1=CC=C(C=C1)C(=O)NC2C(CC3=C2C=C(C=C3)N=C(C)N(C)CC4=CC=C(C=C4)F)O
CHEMBL3616499 acm1_human Human No 7.3 EC50 = 49.5 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
446 6 2 4 3.7 CC1=CC=C(C=C1)C(=O)NC2C(CC3=C2C=C(C=C3)N=C(C)N(C)CC4=CC=C(C=C4)F)O
CHEMBL476990 acm1_human Human No 6.3 EC50 = 490 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
416 4 1 4 3.1 C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5C#N
CHEMBL476990 acm1_human Human No 6.3 EC50 = 490 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
416 4 1 4 3.1 C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5C#N
CHEMBL3823059 acm1_rat Rat No 5.3 EC50 = 4900 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
402 3 0 5 3.9 CN1C=C2C(=N1)C=CC=C2C3=CC(=C(C(=C3)F)CN4C5=CC=CC=C5N=CC4=O)F
CHEMBL1223753 acm1_human Human Yes 8.3 EC50 = 5.0 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
333 2 1 4 2.2 CC1=CC2=C(C=C1F)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL1223753 acm1_human Human Yes 8.3 EC50 = 5.0 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay
333 2 1 4 2.2 CC1=CC2=C(C=C1F)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL2146599 acm1_human Human Yes 8.3 EC50 = 5.0 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
315 2 1 3 2.7 CC1=CC2=C(C=C1)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL2146599 acm1_human Human Yes 8.3 EC50 = 5.0 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
315 2 1 3 2.7 CC1=CC2=C(C=C1)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL335542 acm1_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human M1 receptor Q185E mutant expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor Q185E mutant expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
553 16 0 13 1.2 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOC3=NSN=C3C4=CCCN(C4)C
CHEMBL1084819 acm1_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
363 4 2 2 4.8 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=CC(=C(C=C3)Cl)Cl
CHEMBL1082679 acm1_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
347 4 2 3 3.9 C1CNCCC1CNC(=O)C2=C(C=CC(=C2)F)C3=CC(=CC=C3)Cl
CHEMBL1084805 acm1_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
343 4 1 2 3.7 CN(C1CCNCC1)C(=O)CC2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL335542 acm1_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human M1 receptor Q185E mutant expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor Q185E mutant expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
553 16 0 13 1.2 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOC3=NSN=C3C4=CCCN(C4)C
CHEMBL1084819 acm1_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
363 4 2 2 4.8 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=CC(=C(C=C3)Cl)Cl
CHEMBL1082679 acm1_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
347 4 2 3 3.9 C1CNCCC1CNC(=O)C2=C(C=CC(=C2)F)C3=CC(=CC=C3)Cl
CHEMBL1084805 acm1_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
343 4 1 2 3.7 CN(C1CCNCC1)C(=O)CC2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL3747287 acm1_human Human No 6.3 EC50 = 500 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
401 6 2 4 1.9 C1CC(C1)(CNC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)N5C=CC=N5)O
CHEMBL3747287 acm1_human Human No 6.3 EC50 = 500 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
401 6 2 4 1.9 C1CC(C1)(CNC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)N5C=CC=N5)O
CHEMBL1916235 acm1_rat Rat No 5.3 EC50 = 5000 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
351 5 1 4 2.5 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3CCCC3
CHEMBL1916235 acm1_rat Rat No 5.3 EC50 = 5000 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
351 5 1 4 2.5 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3CCCC3
CHEMBL219118 acm1_human Human No 6.3 EC50 = 501.2 Funct
Agonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
468 16 0 12 3.2 COC1=NSC(=N1)OCCCOCCCOCCCOC2=NSN=C2C3=CN=CC=C3
CHEMBL1085556 acm1_human Human No 6.3 EC50 = 501.2 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
329 4 2 2 3.3 C1CNCCC1C(=O)NCC2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL1083403 acm1_human Human No 6.3 EC50 = 501.2 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
392 3 1 5 4.9 C1CNCCC1C2=NOC(=N2)C3=C(C=CC=C3F)C4=C(C=CC(=C4)Cl)Cl
CHEMBL219118 acm1_human Human No 6.3 EC50 = 501.2 Funct
Agonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
468 16 0 12 3.2 COC1=NSC(=N1)OCCCOCCCOCCCOC2=NSN=C2C3=CN=CC=C3
CHEMBL1085556 acm1_human Human No 6.3 EC50 = 501.2 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
329 4 2 2 3.3 C1CNCCC1C(=O)NCC2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL1083403 acm1_human Human No 6.3 EC50 = 501.2 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
392 3 1 5 4.9 C1CNCCC1C2=NOC(=N2)C3=C(C=CC=C3F)C4=C(C=CC(=C4)Cl)Cl
CHEMBL1082362 acm1_human Human No 5.3 EC50 = 5011.9 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
347 4 2 3 3.9 C1CNCCC1CNC(=O)C2=C(C(=CC=C2)F)C3=CC(=CC=C3)Cl
CHEMBL1082362 acm1_human Human No 5.3 EC50 = 5011.9 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
347 4 2 3 3.9 C1CNCCC1CNC(=O)C2=C(C(=CC=C2)F)C3=CC(=CC=C3)Cl
CHEMBL2333863 acm1_human Human No 5.3 EC50 = 5011.9 Funct
Positive allosteric modulation of human muscarinic M1 receptorPositive allosteric modulation of human muscarinic M1 receptor
487 4 0 4 4.1 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=CC=CC=C4C5(C3=O)CCN(C5)C(=O)C6CCCCC6)F
CHEMBL168561 acm1_human Human No 5.3 EC50 = 5050 Funct
Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholine receptor M1Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholine receptor M1
216 2 0 3 1.9 CC#CCC#CCON=C1CN2CCC1C2
CHEMBL3618436 acm1_human Human No 7.3 EC50 = 51 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
482 5 3 4 4.0 CC(=NC1=CC=C(C=C1)F)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL1243044 acm1_human Human No 7.3 EC50 = 51 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
424 7 1 4 3.2 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C(=O)CCC4=C3C=C(C=C4)F
CHEMBL3608417 acm1_rat Rat No 7.3 EC50 = 51 Funct
Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
449 5 2 6 1.4 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5COCCC5O)F
CHEMBL3618436 acm1_human Human No 7.3 EC50 = 51 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
482 5 3 4 4.0 CC(=NC1=CC=C(C=C1)F)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL1243044 acm1_human Human No 7.3 EC50 = 51 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
424 7 1 4 3.2 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C(=O)CCC4=C3C=C(C=C4)F
CHEMBL3608417 acm1_rat Rat No 7.3 EC50 = 51 Funct
Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
449 5 2 6 1.4 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5COCCC5O)F
CHEMBL513765 acm1_human Human No 6.3 EC50 = 510 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
419 3 1 3 4.1 CC1=CC=CC(=C1)C(=O)N2CCC(CC2)N3CCC(CC3)N4C5=CC=CC=C5NC4=O
CHEMBL513765 acm1_human Human No 6.3 EC50 = 510 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
419 3 1 3 4.1 CC1=CC=CC(=C1)C(=O)N2CCC(CC2)N3CCC(CC3)N4C5=CC=CC=C5NC4=O
CHEMBL1773112 acm1_rat Rat No 5.3 EC50 = 5100 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
462 6 1 6 4.2 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=C(C(=CC=C4)Cl)F
CHEMBL1773112 acm1_rat Rat No 5.3 EC50 = 5100 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
462 6 1 6 4.2 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=C(C(=CC=C4)Cl)F
CHEMBL83074 acm1_human Human No 5.3 EC50 = 5100 Funct
Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholine receptor M1Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholine receptor M1
240 2 0 3 2.1 C#CCC#CCC#CCON=C1CN2CCC1C2
CHEMBL2333872 acm1_human Human No 5.3 EC50 = 5128.6 Funct
Positive allosteric modulation of human muscarinic M1 receptorPositive allosteric modulation of human muscarinic M1 receptor
459 4 0 4 4.3 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=CC=CC=C4C5(C3=O)CCN(C5)C6CCCCC6)F
CHEMBL468290 acm1_rat Rat No 5.3 EC50 = 5180 Funct
Activation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
323 2 0 6 3.4 C1=CC2=C(C(=C1)F)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL468290 acm1_rat Rat No 5.3 EC50 = 5180 Funct
Activation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
323 2 0 6 3.4 C1=CC2=C(C(=C1)F)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL2313512 acm1_human Human No 5.3 EC50 = 5200 Funct
Positive allosteric modulator activity at human muscarinic M1 receptor by calcium mobilization assayPositive allosteric modulator activity at human muscarinic M1 receptor by calcium mobilization assay
337 3 0 4 2.6 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C(=O)COC4=CC=CC=C43)F
CHEMBL1300017 acm1_rat Rat No 5.3 EC50 = 5220 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
427 6 1 6 3.6 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC(=CC=C4)F
CHEMBL1300017 acm1_rat Rat No 5.3 EC50 = 5220 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
427 6 1 6 3.6 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC(=CC=C4)F
CHEMBL3824092 acm1_rat Rat No 5.3 EC50 = 5248.1 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
403 3 0 6 2.7 CN1C=NC2=C1C=C(C=C2)C3=CC(=C(C(=C3)F)CN4C=NC5=C(C4=O)C=CN=C5)F
CHEMBL3824092 acm1_rat Rat No 5.3 EC50 = 5248.1 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
403 3 0 6 2.7 CN1C=NC2=C1C=C(C=C2)C3=CC(=C(C(=C3)F)CN4C=NC5=C(C4=O)C=CN=C5)F
CHEMBL3823885 acm1_human Human No 5.3 EC50 = 5300 Funct
Positive allosteric modulation at human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
403 3 0 6 2.8 CN1C=C2C(=N1)C=CC=C2C3=CC(=C(C(=C3)F)CN4C=NC5=C(C4=O)C=CN=C5)F
CHEMBL3824092 acm1_rat Rat No 5.3 EC50 = 5300 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
403 3 0 6 2.7 CN1C=NC2=C1C=C(C=C2)C3=CC(=C(C(=C3)F)CN4C=NC5=C(C4=O)C=CN=C5)F
CHEMBL3823885 acm1_human Human No 5.3 EC50 = 5300 Funct
Positive allosteric modulation at human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
403 3 0 6 2.8 CN1C=C2C(=N1)C=CC=C2C3=CC(=C(C(=C3)F)CN4C=NC5=C(C4=O)C=CN=C5)F
CHEMBL1300017 acm1_rat Rat No 5.3 EC50 = 5324 Funct
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]
427 6 1 6 3.6 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC(=CC=C4)F
CHEMBL1300017 acm1_rat Rat No 5.3 EC50 = 5324 Funct
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]
427 6 1 6 3.6 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC(=CC=C4)F
CHEMBL3414845 acm1_human Human No 6.3 EC50 = 537.0 Funct
Partial agonist activity at human muscarinic M1 acetylcholine receptor expressed in CHO cells assessed as increase in IP1 accumulation incubated for 30 mins by FRET based HTRF assayPartial agonist activity at human muscarinic M1 acetylcholine receptor expressed in CHO cells assessed as increase in IP1 accumulation incubated for 30 mins by FRET based HTRF assay
329 8 1 2 5.4 CCCCCCCCN1CCC(CC1)N2C3=CC=CC=C3NC2=O
CHEMBL3414845 acm1_human Human No 6.3 EC50 = 537.0 Funct
Partial agonist activity at human muscarinic M1 acetylcholine receptor expressed in CHO cells assessed as increase in IP1 accumulation incubated for 30 mins by FRET based HTRF assayPartial agonist activity at human muscarinic M1 acetylcholine receptor expressed in CHO cells assessed as increase in IP1 accumulation incubated for 30 mins by FRET based HTRF assay
329 8 1 2 5.4 CCCCCCCCN1CCC(CC1)N2C3=CC=CC=C3NC2=O
CHEMBL1773110 acm1_rat Rat No 5.3 EC50 = 5370 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
524 6 1 7 4.4 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC(=CC(=C32)F)F)CC4=CC(=CC=C4)Br
CHEMBL1773110 acm1_rat Rat No 5.3 EC50 = 5370 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
524 6 1 7 4.4 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC(=CC(=C32)F)F)CC4=CC(=CC=C4)Br
CHEMBL511254 acm1_rat Rat Yes 5.3 EC50 = 5380 Funct
Activation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
302 3 0 3 3.0 COC1=CC=C(C=C1)CN2C3=C(C=CC=C3Cl)C(=O)C2=O
CHEMBL511254 acm1_rat Rat Yes 5.3 EC50 = 5380 Funct
Activation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
302 3 0 3 3.0 COC1=CC=C(C=C1)CN2C3=C(C=CC=C3Cl)C(=O)C2=O
CHEMBL3329755 acm1_human Human Yes 5.3 EC50 = 5400 Funct
Activity at human muscarinic acetylcholine receptor subtype 1 expressed in CHO cells by calcium mobilization assayActivity at human muscarinic acetylcholine receptor subtype 1 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL2024412 acm1_human Human No 5.3 EC50 = 5400 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
343 6 2 3 2.5 CC(C)C(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3
CHEMBL3329755 acm1_human Human Yes 5.3 EC50 = 5400 Funct
Activity at human muscarinic acetylcholine receptor subtype 1 expressed in CHO cells by calcium mobilization assayActivity at human muscarinic acetylcholine receptor subtype 1 expressed in CHO cells by calcium mobilization assay
495 6 1 8 3.4 CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4
CHEMBL2024412 acm1_human Human No 5.3 EC50 = 5400 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
343 6 2 3 2.5 CC(C)C(=O)N1C2CCC1CC(C2)NCCNC(=O)C3=CC=CC=C3
CHEMBL1243075 acm1_human Human No 6.3 EC50 = 560 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
436 8 1 4 3.1 COC1=CC2=C(C=C1)N(C(=O)CC2)CCCN3CCC(CC3)NC(=O)CC4=CC=CC=C4
CHEMBL1243075 acm1_human Human No 6.3 EC50 = 560 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
436 8 1 4 3.1 COC1=CC2=C(C=C1)N(C(=O)CC2)CCCN3CCC(CC3)NC(=O)CC4=CC=CC=C4
CHEMBL7303 acm1_human Human Yes 5.3 EC50 = 5603 Funct
Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptorStimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptor
155 2 0 3 0.3 CN1CCC=C(C1)C(=O)OC
CHEMBL2313508 acm1_human Human No 5.3 EC50 = 5623.4 Funct
Positive allosteric modulator activity at human muscarinic M1 receptor by calcium mobilization assayPositive allosteric modulator activity at human muscarinic M1 receptor by calcium mobilization assay
335 3 0 3 2.8 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C(=O)CCC4=CC=CC=C43)F
CHEMBL3402918 acm1_human Human No 5.3 EC50 = 5680 Funct
Agonist activity at human m1 muscarinic acetylcholine receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human m1 muscarinic acetylcholine receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
226 3 0 4 1.3 CN1CCC=C(C1)C2=NOC(C2)CSC
CHEMBL3402918 acm1_human Human No 5.3 EC50 = 5680 Funct
Agonist activity at human m1 muscarinic acetylcholine receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human m1 muscarinic acetylcholine receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
226 3 0 4 1.3 CN1CCC=C(C1)C2=NOC(C2)CSC
CHEMBL2022942 acm1_human Human No 6.2 EC50 = 570 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
352 6 2 4 1.4 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)N3CCCCC3
CHEMBL2022942 acm1_human Human No 6.2 EC50 = 570 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
352 6 2 4 1.4 CCOC(=O)N1C2CCC1CC(C2)NCCNC(=O)N3CCCCC3
CHEMBL142184 acm1_human Human No 6.2 EC50 = 570 Funct
Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.
481 9 0 10 3.4 CN1CCC=C(C1)C2=NSN=C2SCCCCSC3=NSN=C3C4=CCCN(C4)C
CHEMBL3618442 acm1_human Human No 6.2 EC50 = 572 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
508 7 3 4 3.8 CC(=NCC1=CC=CC=C1OC)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3618442 acm1_human Human No 6.2 EC50 = 572 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
508 7 3 4 3.8 CC(=NCC1=CC=CC=C1OC)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3608414 acm1_rat Rat No 7.2 EC50 = 58.6 Funct
Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
449 5 2 6 1.4 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5CCOCC5O)F
CHEMBL3608414 acm1_rat Rat No 7.2 EC50 = 58.6 Funct
Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
449 5 2 6 1.4 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C=C(C4=C3C=CC=N4)C(=O)NC5CCOCC5O)F
CHEMBL1438248 acm1_rat Rat Yes 5.2 EC50 = 5820 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
444 6 1 5 4.1 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC(=CC=C4)Cl
CHEMBL1438248 acm1_rat Rat Yes 5.2 EC50 = 5820 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
444 6 1 5 4.1 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC(=CC=C4)Cl
CHEMBL1438248 acm1_rat Rat Yes 5.2 EC50 = 5857 Funct
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]
444 6 1 5 4.1 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC(=CC=C4)Cl
CHEMBL1438248 acm1_rat Rat Yes 5.2 EC50 = 5857 Funct
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: PAM Calcium Assay Dose-Response with M1. Measurement of intracellular Ca2+ using Fluo-4 dye in CHO-K1 cells stably transfected with rat M1 (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [Primary Screening])]
444 6 1 5 4.1 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC(=CC=C4)Cl
CHEMBL511206 acm1_rat Rat No 5.2 EC50 = 5880 Funct
Activation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
305 2 0 5 3.0 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)C(F)(F)F
CHEMBL511206 acm1_rat Rat No 5.2 EC50 = 5880 Funct
Activation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
305 2 0 5 3.0 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)C(F)(F)F
CHEMBL2024331 acm1_human Human No 7.2 EC50 = 59 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
400 5 1 4 3.6 CCOC(=O)N1C2CCC1CC(C2)N3CCCC(C3)NC(=O)C4=CC=CC=C4C
CHEMBL2024331 acm1_human Human No 7.2 EC50 = 59 Funct
Agonist activity at human muscarinic M1 receptorAgonist activity at human muscarinic M1 receptor
400 5 1 4 3.6 CCOC(=O)N1C2CCC1CC(C2)N3CCCC(C3)NC(=O)C4=CC=CC=C4C
CHEMBL341759 acm1_human Human No 6.2 EC50 = 590 Funct
Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.
509 11 0 10 4.1 CN1CCC=C(C1)C2=NSN=C2SCCCCCCSC3=NSN=C3C4=CCCN(C4)C
CHEMBL168545 acm1_human Human No 5.2 EC50 = 5900 Funct
Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholine receptor M1Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholine receptor M1
192 2 0 3 1.6 CCC#CCON=C1CN2CCC1C2
CHEMBL2059306 acm1_human Human No 8.2 EC50 = 6.3 Funct
Agonist activity at human muscarinic M1 receptor Y381A mutant expressed in BHK-21 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M1 receptor Y381A mutant expressed in BHK-21 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
405 5 1 3 3.8 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL1916225 acm1_rat Rat No 7.2 EC50 = 60 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
391 5 1 5 3.1 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=C(C=C(C=C3)F)C
CHEMBL1916225 acm1_rat Rat No 7.2 EC50 = 60 Funct
Agonist activity at rat muscarinic M1 receptor expressed in CHO cellsAgonist activity at rat muscarinic M1 receptor expressed in CHO cells
391 5 1 5 3.1 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=C(C=C(C=C3)F)C
CHEMBL3414847 acm1_human Human No 7.2 EC50 = 60.3 Funct
Partial agonist activity at human muscarinic M1 acetylcholine receptor expressed in CHO cells assessed as increase in IP1 accumulation incubated for 30 mins by FRET based HTRF assayPartial agonist activity at human muscarinic M1 acetylcholine receptor expressed in CHO cells assessed as increase in IP1 accumulation incubated for 30 mins by FRET based HTRF assay
674 14 2 9 6.0 CCC1C(=O)N(C2(S1)CCNCC2)CCCCCCCCOC3=CC4=C(C=C3)C=C(C=C4)CN5C=C(C(=O)C6=C5C(=CC=C6)F)C(=O)O
CHEMBL3414847 acm1_human Human No 7.2 EC50 = 60.3 Funct
Partial agonist activity at human muscarinic M1 acetylcholine receptor expressed in CHO cells assessed as increase in IP1 accumulation incubated for 30 mins by FRET based HTRF assayPartial agonist activity at human muscarinic M1 acetylcholine receptor expressed in CHO cells assessed as increase in IP1 accumulation incubated for 30 mins by FRET based HTRF assay
674 14 2 9 6.0 CCC1C(=O)N(C2(S1)CCNCC2)CCCCCCCCOC3=CC4=C(C=C3)C=C(C=C4)CN5C=C(C(=O)C6=C5C(=CC=C6)F)C(=O)O
CHEMBL1083203 acm1_human Human No 6.2 EC50 = 600 Funct
Positive allosteric modulation of human muscarinic M1 receptorPositive allosteric modulation of human muscarinic M1 receptor
335 3 0 4 2.4 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=CC=CC=C4C(=O)C3=O)F
CHEMBL523685 acm1_human Human Yes 5.2 EC50 = 6000 Funct
Positive allosteric modulation activity at muscarinic M1 receptorPositive allosteric modulation activity at muscarinic M1 receptor
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL523685 acm1_human Human Yes 5.2 EC50 = 6000 Funct
Positive allosteric modulation activity at muscarinic M1 receptorPositive allosteric modulation activity at muscarinic M1 receptor
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL1083203 acm1_human Human No 6.2 EC50 = 602.6 Funct
Positive allosteric modulator activity at human muscarinic M1 receptor by calcium mobilization assayPositive allosteric modulator activity at human muscarinic M1 receptor by calcium mobilization assay
335 3 0 4 2.4 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=CC=CC=C4C(=O)C3=O)F
CHEMBL523685 acm1_rat Rat Yes 5.2 EC50 = 6040 Funct
Activation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL523685 acm1_rat Rat Yes 5.2 EC50 = 6040 Funct
Activation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL1242923 acm1_human Human Yes 7.2 EC50 = 61 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
408 7 1 4 2.9 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C(=O)COC4=CC=CC=C43
CHEMBL1242923 acm1_human Human Yes 7.2 EC50 = 61 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
408 7 1 4 2.9 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C(=O)COC4=CC=CC=C43
CHEMBL1242923 acm1_human Human Yes 7.2 EC50 = 61 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
408 7 1 4 2.9 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C(=O)COC4=CC=CC=C43
CHEMBL1242923 acm1_human Human Yes 7.2 EC50 = 61 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
408 7 1 4 2.9 C1CN(CCC1NC(=O)CC2=CC=CC=C2)CCCN3C(=O)COC4=CC=CC=C43
CHEMBL417560 acm1_human Human No 7.2 EC50 = 61.9 Funct
Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.
325 4 0 5 3.1 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC=CC=C5
CHEMBL523685 acm1_rat Rat Yes 5.2 EC50 = 6100 Funct
Agonist activity at rat muscarinic M1 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at rat muscarinic M1 expressed in CHO cells assessed as stimulation of calcium mobilization
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL3823781 acm1_rat Rat No 5.2 EC50 = 6100 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
400 3 0 6 3.3 C1=CC2=C(C=CN=C2)C=C1C3=CC(=C(C(=C3)F)CN4C=NC5=C(C4=O)C=CN=C5)F
CHEMBL523685 acm1_human Human Yes 5.2 EC50 = 6100 Funct
Positive allosteric modulation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL523685 acm1_rat Rat Yes 5.2 EC50 = 6100 Funct
Agonist activity at rat muscarinic M1 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at rat muscarinic M1 expressed in CHO cells assessed as stimulation of calcium mobilization
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL3823781 acm1_rat Rat No 5.2 EC50 = 6100 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
400 3 0 6 3.3 C1=CC2=C(C=CN=C2)C=C1C3=CC(=C(C(=C3)F)CN4C=NC5=C(C4=O)C=CN=C5)F
CHEMBL523685 acm1_human Human Yes 5.2 EC50 = 6100 Funct
Positive allosteric modulation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assayPositive allosteric modulation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay
316 2 0 2 2.8 C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br
CHEMBL3823781 acm1_rat Rat No 5.2 EC50 = 6166.0 Funct
Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilizationPositive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
400 3 0 6 3.3 C1=CC2=C(C=CN=C2)C=C1C3=CC(=C(C(=C3)F)CN4C=NC5=C(C4=O)C=CN=C5)F
CHEMBL3354069 acm1_human Human No 4.2 EC50 = 61659.5 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based beta-arrestin engagement assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based beta-arrestin engagement assay
594 16 0 7 7.0 CN1CCC=C(C1)C2=NSN=C2OCCCCCCCCCC3CCN(CC3)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL3354069 acm1_human Human No 4.2 EC50 = 61659.5 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based beta-arrestin engagement assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based beta-arrestin engagement assay
594 16 0 7 7.0 CN1CCC=C(C1)C2=NSN=C2OCCCCCCCCCC3CCN(CC3)CCCN4C(=O)CCC5=CC=CC=C54
CHEMBL340021 acm1_human Human No 5.2 EC50 = 6202 Funct
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
229 6 1 6 1.6 CCCCOC1=NSN=C1OC2CNC2
CHEMBL467281 acm1_rat Rat No 5.2 EC50 = 6210 Funct
Activation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
323 2 0 6 3.4 C1=CC=C(C(=C1)CN2C3=C(C=C(C=C3)F)C(=O)C2=O)C(F)(F)F
CHEMBL467281 acm1_rat Rat No 5.2 EC50 = 6210 Funct
Activation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M1 receptor expressed in CHO cells co-expressing Gq protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
323 2 0 6 3.4 C1=CC=C(C(=C1)CN2C3=C(C=C(C=C3)F)C(=O)C2=O)C(F)(F)F
CHEMBL3747166 acm1_human Human No 7.2 EC50 = 63 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
417 5 2 5 1.3 C1COCC(C1NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)N5C=CC=N5)O
CHEMBL3747166 acm1_human Human No 7.2 EC50 = 63 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
417 5 2 5 1.3 C1COCC(C1NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)N5C=CC=N5)O
CHEMBL216927 acm1_human Human Yes 7.2 EC50 = 63.1 Funct
Agonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
488 16 0 13 1.2 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOC3=NSN=C3OC
CHEMBL1085985 acm1_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
365 4 2 4 3.8 C1CNCCC1(CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl)F
CHEMBL1085507 acm1_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
329 4 2 2 3.8 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL1083414 acm1_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
363 4 2 2 4.4 C1CNCCC1CNC(=O)C2=C(C=CC=C2Cl)C3=CC(=CC=C3)Cl
CHEMBL1083402 acm1_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
364 5 1 3 4.1 C1CNCCC1CCS(=O)(=O)C2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL2146598 acm1_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
301 2 1 3 2.4 C1CN(CCC1N2C3=CC=CC=C3NC2=O)C4CCOCC4
CHEMBL216927 acm1_human Human Yes 7.2 EC50 = 63.1 Funct
Agonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysisAgonist activity at human M1 receptor expressed in A9 L cells assessed as stimulation of phosphoinositide hydrolysis
488 16 0 13 1.2 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOC3=NSN=C3OC
CHEMBL1085985 acm1_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
365 4 2 4 3.8 C1CNCCC1(CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl)F
CHEMBL1085507 acm1_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
329 4 2 2 3.8 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL1083414 acm1_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
363 4 2 2 4.4 C1CNCCC1CNC(=O)C2=C(C=CC=C2Cl)C3=CC(=CC=C3)Cl
CHEMBL1083402 acm1_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay
364 5 1 3 4.1 C1CNCCC1CCS(=O)(=O)C2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL2146598 acm1_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
301 2 1 3 2.4 C1CN(CCC1N2C3=CC=CC=C3NC2=O)C4CCOCC4
CHEMBL3608416 acm1_rat Rat No 7.2 EC50 = 63.2 Funct
Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
464 5 2 6 1.5 CC1(COCCC1NC(=O)C2=CN(C3=C2N=CC=C3)CC4=C(C=C(C=C4)C5=CN(N=C5)C)F)O
CHEMBL3608416 acm1_rat Rat No 7.2 EC50 = 63.2 Funct
Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assayPositive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIPR assay
464 5 2 6 1.5 CC1(COCCC1NC(=O)C2=CN(C3=C2N=CC=C3)CC4=C(C=C(C=C4)C5=CN(N=C5)C)F)O
CHEMBL134641 acm1_human Human Yes 7.2 EC50 = 63.6 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
193 2 0 4 1.0 CON=C(C#N)C1CN2CCC1CC2
CHEMBL134641 acm1_human Human Yes 7.2 EC50 = 63.6 Funct
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
193 2 0 4 1.0 CON=C(C#N)C1CN2CCC1CC2
CHEMBL965 acm1_human Human Yes 6.2 EC50 = 631.0 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assay
147 4 1 2 -0.4 C[N+](C)(C)CCOC(=O)N
CHEMBL965 acm1_human Human Yes 6.2 EC50 = 631.0 Funct
Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assayAgonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assay
147 4 1 2 -0.4 C[N+](C)(C)CCOC(=O)N
CHEMBL3360935 acm1_human Human No 5.2 EC50 = 6309.6 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
366 4 0 4 3.3 C1=CC=C(C=C1)CN2C=C3C(=NN(C3=O)CC4=CN=CC=C4)C5=CC=CC=C52
CHEMBL2333862 acm1_human Human No 5.2 EC50 = 6309.6 Funct
Positive allosteric modulation of human muscarinic M1 receptorPositive allosteric modulation of human muscarinic M1 receptor
459 4 0 4 3.0 CN1C=C(C=N1)C2=CC(=C(C=C2)CN3C4=CC=CC=C4C5(C3=O)CCN(C5)C(=O)C6CCC6)F
CHEMBL3360935 acm1_human Human No 5.2 EC50 = 6309.6 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
366 4 0 4 3.3 C1=CC=C(C=C1)CN2C=C3C(=NN(C3=O)CC4=CN=CC=C4)C5=CC=CC=C52
CHEMBL3360935 acm1_human Human No 5.2 EC50 = 6310 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
366 4 0 4 3.3 C1=CC=C(C=C1)CN2C=C3C(=NN(C3=O)CC4=CN=CC=C4)C5=CC=CC=C52
CHEMBL3747781 acm1_human Human No 7.2 EC50 = 65 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
417 5 3 5 1.3 C1COCC(C1NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)C5=CC=NN5)O
CHEMBL3747781 acm1_human Human No 7.2 EC50 = 65 Funct
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayPositive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
417 5 3 5 1.3 C1COCC(C1NC(=O)C2=CN(C3=C2N=CC=C3)CC4=CC=C(C=C4)C5=CC=NN5)O
CHEMBL486331 acm1_human Human No 5.2 EC50 = 6500 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
520 4 2 7 4.5 C1CN(CCC1N2C3=CC=CC=C3NC2=O)C4CCN(CC4)C(=O)NC5=CC(=CC=C5)SC(F)(F)F
CHEMBL486331 acm1_human Human No 5.2 EC50 = 6500 Funct
Agonist activity at muscarinic M1 receptorAgonist activity at muscarinic M1 receptor
520 4 2 7 4.5 C1CN(CCC1N2C3=CC=CC=C3NC2=O)C4CCN(CC4)C(=O)NC5=CC(=CC=C5)SC(F)(F)F
CHEMBL1773270 acm1_rat Rat No 5.2 EC50 = 6540 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
439 7 1 6 3.4 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC(=CC=C4)OC
CHEMBL1773270 acm1_rat Rat No 5.2 EC50 = 6540 Funct
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assayAllosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
439 7 1 6 3.4 CC1=CC(=NO1)NC(=O)CS(=O)(=O)C2=CN(C3=CC=CC=C32)CC4=CC(=CC=C4)OC
CHEMBL3360938 acm1_human Human No 6.2 EC50 = 656 Funct
Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assayPositive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay
411 4 0 4 5.2 CC1=CC(=C(C=C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC=CC=C5F)C
CHEMBL2059323 acm1_human Human No 7.2 EC50 = 66 Funct
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 min