Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL414185 ada1d_human Human No 9.3 EC50 = 0.5 Funct
Effective concentration showing agonistic activity towards Human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells was determinedEffective concentration showing agonistic activity towards Human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells was determined
233 5 2 4 1.3 COC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL414185 ada1d_human Human No 9.3 EC50 = 0.5 Funct
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
233 5 2 4 1.3 COC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL414185 ada1d_human Human No 9.3 EC50 = 0.5 Funct
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
233 5 2 4 1.3 COC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL72441 ada1d_human Human No 9.0 EC50 = 0.9 Funct
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
235 4 2 3 1.8 CC1=CC(=C(C=C1)SC)NCC2=NCCN2
CHEMBL95523 ada1d_human Human No 8.0 EC50 = 10 Funct
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
232 4 3 3 0.8 CNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL327005 ada1d_human Human No 7.0 EC50 = 100 Funct
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
243 4 1 4 1.0 C1CN=C(N1)COC2=CC=CC=C2C3=CC=NO3
CHEMBL188760 ada1d_rat Rat Yes 6.0 EC50 = 1000 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
197 4 1 4 2.5 C1=CC(=CC=C1CCCO[N+](=O)[O-])O
CHEMBL188760 ada1d_rat Rat Yes 6.0 EC50 = 1000 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
197 4 1 4 2.5 C1=CC(=CC=C1CCCO[N+](=O)[O-])O
CHEMBL188200 ada1d_rat Rat No 5.0 EC50 = 10000 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
339 6 1 6 3.8 CC1=C(C(=C2CCC(OC2=C1C)(C)COCCCO[N+](=O)[O-])C)O
CHEMBL207846 ada1d_rat Rat No 5.0 EC50 = 10000 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
352 5 0 4 3.7 CC(C)(C)N1C(=O)C2=CC=CC=C2C(=N1)CC3=CC(=C(C=C3)OC)OC
CHEMBL188200 ada1d_rat Rat No 5.0 EC50 = 10000 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
339 6 1 6 3.8 CC1=C(C(=C2CCC(OC2=C1C)(C)COCCCO[N+](=O)[O-])C)O
CHEMBL207846 ada1d_rat Rat No 5.0 EC50 = 10000 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
352 5 0 4 3.7 CC(C)(C)N1C(=O)C2=CC=CC=C2C(=N1)CC3=CC(=C(C=C3)OC)OC
CHEMBL336161 ada1d_rat Rat No 6.0 EC50 = 1023.3 Funct
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
309 3 3 5 0.4 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NCCN3)O
CHEMBL187824 ada1d_rat Rat No 7.0 EC50 = 110 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
489 9 1 7 6.7 CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CCCOC2=NO[N+](=C2S(=O)(=O)C3=CC=CC=C3)[O-]
CHEMBL187824 ada1d_rat Rat No 7.0 EC50 = 110 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
489 9 1 7 6.7 CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CCCOC2=NO[N+](=C2S(=O)(=O)C3=CC=CC=C3)[O-]
CHEMBL468711 ada1d_human Human No 6.9 EC50 = 119 Funct
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
261 2 0 2 2.3 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=CN=CC=C4
CHEMBL468711 ada1d_human Human No 6.9 EC50 = 119 Funct
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
261 2 0 2 2.3 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=CN=CC=C4
CHEMBL363325 ada1d_rat Rat No 7.9 EC50 = 12 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
270 4 0 6 1.8 CCOC1=NO[N+](=C1S(=O)(=O)C2=CC=CC=C2)[O-]
CHEMBL189804 ada1d_rat Rat No 7.9 EC50 = 12 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
376 7 1 7 3.4 C1=CC=C(C=C1)S(=O)(=O)C2=[N+](ON=C2OCCCC3=CC=C(C=C3)O)[O-]
CHEMBL363325 ada1d_rat Rat No 7.9 EC50 = 12 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
270 4 0 6 1.8 CCOC1=NO[N+](=C1S(=O)(=O)C2=CC=CC=C2)[O-]
CHEMBL189804 ada1d_rat Rat No 7.9 EC50 = 12 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
376 7 1 7 3.4 C1=CC=C(C=C1)S(=O)(=O)C2=[N+](ON=C2OCCCC3=CC=C(C=C3)O)[O-]
CHEMBL422477 ada1d_human Human No 7.9 EC50 = 12.6 Funct
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
258 4 1 3 2.2 C1CN=C(N1)COC2=CC=CC=C2C3=CSC=C3
CHEMBL188200 ada1d_rat Rat No 5.9 EC50 = 1200 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
339 6 1 6 3.8 CC1=C(C(=C2CCC(OC2=C1C)(C)COCCCO[N+](=O)[O-])C)O
CHEMBL207779 ada1d_rat Rat No 5.9 EC50 = 1200 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
319 2 0 2 4.1 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=C(C=C(C=C3)Cl)Cl
CHEMBL188200 ada1d_rat Rat No 5.9 EC50 = 1200 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
339 6 1 6 3.8 CC1=C(C(=C2CCC(OC2=C1C)(C)COCCCO[N+](=O)[O-])C)O
CHEMBL207779 ada1d_rat Rat No 5.9 EC50 = 1200 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
319 2 0 2 4.1 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=C(C=C(C=C3)Cl)Cl
CHEMBL1945039 ada1d_human Human No 6.9 EC50 = 125.9 Funct
Binding affinity to Alpha-1D adrenoceptor expressed in HEK cells by calcium flux assayBinding affinity to Alpha-1D adrenoceptor expressed in HEK cells by calcium flux assay
480 11 5 7 2.8 COC1=CC=CC=C1CNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL13852 ada1d_human Human Yes 6.9 EC50 = 125.9 Funct
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
216 4 1 2 1.8 C1CC1C2=CC=CC=C2OCC3=NCCN3
CHEMBL13852 ada1d_human Human Yes 6.9 EC50 = 125.9 Funct
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
216 4 1 2 1.8 C1CC1C2=CC=CC=C2OCC3=NCCN3
CHEMBL273316 ada1d_human Human No 6.9 EC50 = 125.9 Funct
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
270 5 2 4 1.0 CCN1C(=NC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL1945039 ada1d_human Human No 6.9 EC50 = 125.9 Funct
Binding affinity to Alpha-1D adrenoceptor expressed in HEK cells by calcium flux assayBinding affinity to Alpha-1D adrenoceptor expressed in HEK cells by calcium flux assay
480 11 5 7 2.8 COC1=CC=CC=C1CNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL13852 ada1d_human Human Yes 6.9 EC50 = 125.9 Funct
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
216 4 1 2 1.8 C1CC1C2=CC=CC=C2OCC3=NCCN3
CHEMBL13852 ada1d_human Human Yes 6.9 EC50 = 125.9 Funct
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
216 4 1 2 1.8 C1CC1C2=CC=CC=C2OCC3=NCCN3
CHEMBL207967 ada1d_rat Rat No 6.9 EC50 = 130 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
242 4 1 6 1.9 C1=CC(=CC=C1CC(CO[N+](=O)[O-])[N+](=O)[O-])O
CHEMBL207967 ada1d_rat Rat No 6.9 EC50 = 130 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
242 4 1 6 1.9 C1=CC(=CC=C1CC(CO[N+](=O)[O-])[N+](=O)[O-])O
CHEMBL209043 ada1d_rat Rat No 5.9 EC50 = 1300 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
299 3 0 2 3.8 CCN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=C(C=C3)Cl
CHEMBL209043 ada1d_rat Rat No 5.9 EC50 = 1300 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
299 3 0 2 3.8 CCN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=C(C=C3)Cl
CHEMBL407308 ada1d_human Human No 5.9 EC50 = 1390 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
251 2 1 3 2.3 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=NC=CO4
CHEMBL407308 ada1d_human Human No 5.9 EC50 = 1390 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
251 2 1 3 2.3 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=NC=CO4
CHEMBL207120 ada1d_rat Rat Yes 5.9 EC50 = 1400 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
285 2 0 2 3.4 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=CC=C3Cl
CHEMBL207120 ada1d_rat Rat Yes 5.9 EC50 = 1400 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
285 2 0 2 3.4 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=CC=C3Cl
CHEMBL377068 ada1d_rat Rat Yes 4.9 EC50 = 14000 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
300 2 0 2 4.0 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=CC4=CC=CC=C43
CHEMBL377068 ada1d_rat Rat Yes 4.9 EC50 = 14000 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
300 2 0 2 4.0 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=CC4=CC=CC=C43
CHEMBL448802 ada1d_human Human No 6.8 EC50 = 146 Funct
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
251 2 0 3 1.8 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=NC=CO4
CHEMBL448802 ada1d_human Human No 6.8 EC50 = 146 Funct
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
251 2 0 3 1.8 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=NC=CO4
CHEMBL143801 ada1d_human Human No 7.8 EC50 = 15.9 Funct
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
258 4 1 3 2.3 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CS3
CHEMBL17856 ada1d_human Human No 7.8 EC50 = 15.9 Funct
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
255 4 2 3 0.9 CN1C=CC(=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL95565 ada1d_human Human No 7.8 EC50 = 15.9 Funct
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
274 6 3 3 2.1 CC(C)CNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL99559 ada1d_human Human No 7.8 EC50 = 15.9 Funct
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
275 8 2 4 2.6 CCCCOC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL380475 ada1d_rat Rat No 5.8 EC50 = 1500 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
390 5 2 7 2.7 CC1=C(C(=C2CCC(OC2=C1C)(C)CN(C)CC3=NO[N+](=C3C(=O)N)[O-])C)O
CHEMBL380475 ada1d_rat Rat No 5.8 EC50 = 1500 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
390 5 2 7 2.7 CC1=C(C(=C2CCC(OC2=C1C)(C)CN(C)CC3=NO[N+](=C3C(=O)N)[O-])C)O
CHEMBL318544 ada1d_human Human No 6.8 EC50 = 158.5 Funct
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
260 6 3 3 1.7 CCCNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL356605 ada1d_human Human No 6.8 EC50 = 158.5 Funct
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
253 4 1 3 1.5 C1CN=C(N1)COC2=CC=CC=C2C3=CN=CC=C3
CHEMBL318544 ada1d_human Human No 6.8 EC50 = 158.5 Funct
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
260 6 3 3 1.7 CCCNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL152155 ada1d_human Human No 7.8 EC50 = 16.2 Funct
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
241 4 2 3 1.7 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=CO3
CHEMBL346380 ada1d_human Human No 7.7 EC50 = 18.2 Funct
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
257 4 2 3 2.3 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=CS3
CHEMBL349082 ada1d_human Human No 6.7 EC50 = 182.0 Funct
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
253 4 2 4 0.5 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=CN=C3
CHEMBL1076 ada1d_rat Rat Yes 5.7 EC50 = 1862.1 Funct
Agonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aortaAgonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta
197 4 2 4 0.1 COC1=CC(=C(C=C1)OC)C(CN)O
CHEMBL118055 ada1d_human Human Yes 7.7 EC50 = 20.0 Funct
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
219 4 2 3 2.1 CSC1=CC=CC=C1NCC2=CN=CN2
CHEMBL275844 ada1d_human Human No 7.7 EC50 = 20.0 Funct
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
241 4 3 3 0.9 C1CN=C(N1)CNC2=CC=CC=C2C3=CNN=C3
CHEMBL277375 ada1d_human Human No 7.7 EC50 = 20.0 Funct
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
241 4 3 3 0.9 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=NN3
CHEMBL378274 ada1d_rat Rat Yes 5.7 EC50 = 1900 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
271 2 1 2 3.2 C1=CC=C(C(=C1)CC2=NNC(=O)C3=CC=CC=C32)Cl
CHEMBL1076 ada1d_rat Rat Yes 5.7 EC50 = 1900 Funct
Effective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uMEffective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uM
197 4 2 4 0.1 COC1=CC(=C(C=C1)OC)C(CN)O
CHEMBL378274 ada1d_rat Rat Yes 5.7 EC50 = 1900 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
271 2 1 2 3.2 C1=CC=C(C(=C1)CC2=NNC(=O)C3=CC=CC=C32)Cl
CHEMBL380475 ada1d_rat Rat No 4.7 EC50 = 19000 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
390 5 2 7 2.7 CC1=C(C(=C2CCC(OC2=C1C)(C)CN(C)CC3=NO[N+](=C3C(=O)N)[O-])C)O
CHEMBL380475 ada1d_rat Rat No 4.7 EC50 = 19000 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
390 5 2 7 2.7 CC1=C(C(=C2CCC(OC2=C1C)(C)CN(C)CC3=NO[N+](=C3C(=O)N)[O-])C)O
CHEMBL18256 ada1d_human Human No 6.7 EC50 = 199.5 Funct
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
255 4 2 3 0.7 CN1C=CN=C1C2=CC=CC=C2NCC3=NCCN3
CHEMBL100198 ada1d_human Human No 6.7 EC50 = 199.5 Funct
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
246 4 2 3 0.9 CN(C)C(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL70751 ada1d_human Human No 8.6 EC50 = 2.7 Funct
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
256 4 2 3 2.1 CSC1=C(C=C(C=C1)Cl)NCC2=NCCN2
CHEMBL155327 ada1d_human Human No 8.5 EC50 = 2.9 Funct
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
242 4 2 4 1.0 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=NO3
CHEMBL72768 ada1d_human Human No 7.7 EC50 = 21.9 Funct
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
239 4 2 4 1.5 CSC1=C(C=C(C=C1)F)NCC2=NCCN2
CHEMBL208390 ada1d_rat Rat No 7.7 EC50 = 22 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
436 9 1 9 3.3 COC1=CC(=CC(=C1O)OC)CCCOC2=NO[N+](=C2S(=O)(=O)C3=CC=CC=C3)[O-]
CHEMBL208390 ada1d_rat Rat No 7.7 EC50 = 22 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
436 9 1 9 3.3 COC1=CC(=CC(=C1O)OC)CCCOC2=NO[N+](=C2S(=O)(=O)C3=CC=CC=C3)[O-]
CHEMBL67126 ada1d_rat Rat Yes 5.7 EC50 = 2200 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
310 4 0 4 2.7 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC(=C(C=C3)OC)OC
CHEMBL67126 ada1d_rat Rat Yes 5.7 EC50 = 2200 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
310 4 0 4 2.7 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC(=C(C=C3)OC)OC
CHEMBL206527 ada1d_rat Rat Yes 6.6 EC50 = 240 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
166 3 0 6 1.2 CC(CO[N+](=O)[O-])O[N+](=O)[O-]
CHEMBL206527 ada1d_rat Rat Yes 6.6 EC50 = 240 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
166 3 0 6 1.2 CC(CO[N+](=O)[O-])O[N+](=O)[O-]
CHEMBL142387 ada1d_human Human No 7.6 EC50 = 25.1 Funct
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
259 4 1 4 1.6 C1CN=C(N1)COC2=CC=CC=C2C3=CC=NS3
CHEMBL17492 ada1d_human Human No 6.6 EC50 = 251.2 Funct
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
254 4 2 2 1.3 CN1C=CC=C1C2=CC=CC=C2NCC3=NCCN3
CHEMBL17776 ada1d_human Human No 6.6 EC50 = 251.2 Funct
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
284 6 2 4 1.5 CCCN1C(=NC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL95398 ada1d_human Human No 6.6 EC50 = 251.2 Funct
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
275 7 2 4 2.7 CC(C)COC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL109783 ada1d_rat Rat Yes 5.6 EC50 = 2570.4 Funct
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
309 3 3 5 0.4 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NCCN3)O
CHEMBL207277 ada1d_rat Rat Yes 5.6 EC50 = 2600 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
311 4 0 2 4.1 C=CCN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=C(C=C3)Cl
CHEMBL109783 ada1d_rat Rat Yes 5.6 EC50 = 2600 Funct
Effective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uMEffective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uM
309 3 3 5 0.4 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NCCN3)O
CHEMBL207277 ada1d_rat Rat Yes 5.6 EC50 = 2600 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
311 4 0 2 4.1 C=CCN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=C(C=C3)Cl
CHEMBL466634 ada1d_human Human No 6.6 EC50 = 276 Funct
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
269 2 0 4 1.9 C1C(CN2C1=NC=C2)C3=C(C=CC(=C3)F)C4=NC=CO4
CHEMBL511211 ada1d_human Human No 6.6 EC50 = 276 Funct
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
268 2 1 3 1.8 C1C(CN2C1=NC=C2)C3=C(C=C(C=C3)F)C4=CC=NN4
CHEMBL466634 ada1d_human Human No 6.6 EC50 = 276 Funct
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
269 2 0 4 1.9 C1C(CN2C1=NC=C2)C3=C(C=CC(=C3)F)C4=NC=CO4
CHEMBL511211 ada1d_human Human No 6.6 EC50 = 276 Funct
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
268 2 1 3 1.8 C1C(CN2C1=NC=C2)C3=C(C=C(C=C3)F)C4=CC=NN4
CHEMBL156893 ada1d_human Human No 7.5 EC50 = 28.8 Funct
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
268 4 3 5 0.5 C1CN=C(N1)CNC2=CC=CC=C2C3=NC(=NC=C3)N
CHEMBL66433 ada1d_rat Rat Yes 5.5 EC50 = 2900 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
280 2 1 4 2.4 C1OC2=C(O1)C=C(C=C2)CC3=NNC(=O)C4=CC=CC=C43
CHEMBL66433 ada1d_rat Rat Yes 5.5 EC50 = 2900 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
280 2 1 4 2.4 C1OC2=C(O1)C=C(C=C2)CC3=NNC(=O)C4=CC=CC=C43
CHEMBL208355 ada1d_rat Rat Yes 4.5 EC50 = 29000 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
392 3 0 4 4.8 C1=CC=C2C(=C1)C(=NN(C2=O)C3=CC=C(C=C3)[N+](=O)[O-])CC4=CC=C(C=C4)Cl
CHEMBL208355 ada1d_rat Rat Yes 4.5 EC50 = 29000 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
392 3 0 4 4.8 C1=CC=C2C(=C1)C(=NN(C2=O)C3=CC=C(C=C3)[N+](=O)[O-])CC4=CC=C(C=C4)Cl
CHEMBL17491 ada1d_human Human No 8.4 EC50 = 4.0 Funct
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
242 4 3 4 0.7 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=NN3
CHEMBL511411 ada1d_human Human No 6.5 EC50 = 301 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
202 1 0 2 1.9 C1C(CN2C1=NC=C2)C3=CC=CC=C3F
CHEMBL511411 ada1d_human Human No 6.5 EC50 = 301 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
202 1 0 2 1.9 C1C(CN2C1=NC=C2)C3=CC=CC=C3F
CHEMBL114669 ada1d_human Human No 7.5 EC50 = 31.6 Funct
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
241 3 3 3 1.8 C1CN=C(N1)CNC2=CC=CC3=C2C=C(C=C3)O
CHEMBL142871 ada1d_human Human No 7.5 EC50 = 31.6 Funct
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
259 4 1 4 1.6 C1CN=C(N1)COC2=CC=CC=C2C3=NC=CS3
CHEMBL207437 ada1d_rat Rat No 5.5 EC50 = 3100 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
186 3 1 5 -0.2 CN(C)CC1=NO[N+](=C1C(=O)N)[O-]
CHEMBL207437 ada1d_rat Rat No 5.5 EC50 = 3100 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
186 3 1 5 -0.2 CN(C)CC1=NO[N+](=C1C(=O)N)[O-]
CHEMBL98016 ada1d_human Human No 6.5 EC50 = 316.2 Funct
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
260 5 3 3 1.6 CC(C)NC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL17151 ada1d_human Human No 5.5 EC50 = 3162.3 Funct
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
284 5 2 4 1.4 CC(C)N1C(=NC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL406316 ada1d_human Human No 6.5 EC50 = 319 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
250 2 2 2 2.1 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=CNN=C4
CHEMBL406316 ada1d_human Human No 6.5 EC50 = 319 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
250 2 2 2 2.1 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=CNN=C4
CHEMBL260116 ada1d_human Human No 5.5 EC50 = 3190 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
267 2 1 3 2.9 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=NC=CS4
CHEMBL260116 ada1d_human Human No 5.5 EC50 = 3190 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
267 2 1 3 2.9 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=NC=CS4
CHEMBL70692 ada1d_human Human No 7.5 EC50 = 33.9 Funct
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
239 4 2 4 1.5 CSC1=C(C=CC=C1F)NCC2=NCCN2
CHEMBL381519 ada1d_rat Rat No 5.5 EC50 = 3300 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
354 6 1 6 5.3 CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CC(CO[N+](=O)[O-])[N+](=O)[O-]
CHEMBL381519 ada1d_rat Rat No 5.5 EC50 = 3300 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
354 6 1 6 5.3 CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CC(CO[N+](=O)[O-])[N+](=O)[O-]
CHEMBL256983 ada1d_human Human No 6.5 EC50 = 336 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
250 2 2 2 2.2 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=CC=NN4
CHEMBL256983 ada1d_human Human No 6.5 EC50 = 336 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
250 2 2 2 2.2 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=CC=NN4
CHEMBL466869 ada1d_human Human No 5.5 EC50 = 3500 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
228 2 1 2 2.5 COC1=CC=CC=C1C2CCC3=C(C2)NC=N3
CHEMBL466869 ada1d_human Human No 5.5 EC50 = 3500 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
228 2 1 2 2.5 COC1=CC=CC=C1C2CCC3=C(C2)NC=N3
CHEMBL189804 ada1d_rat Rat No 6.4 EC50 = 360 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
376 7 1 7 3.4 C1=CC=C(C=C1)S(=O)(=O)C2=[N+](ON=C2OCCCC3=CC=C(C=C3)O)[O-]
CHEMBL189804 ada1d_rat Rat No 6.4 EC50 = 360 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
376 7 1 7 3.4 C1=CC=C(C=C1)S(=O)(=O)C2=[N+](ON=C2OCCCC3=CC=C(C=C3)O)[O-]
CHEMBL258007 ada1d_human Human No 6.4 EC50 = 364 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
198 1 1 1 2.7 C1CC(C2=CC=CC=C2C1)C3=NC=CN3
CHEMBL449284 ada1d_human Human No 6.4 EC50 = 364 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
219 1 0 1 2.4 C1C(CN2C1=NC=C2)C3=CC=CC=C3Cl
CHEMBL258007 ada1d_human Human No 6.4 EC50 = 364 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
198 1 1 1 2.7 C1CC(C2=CC=CC=C2C1)C3=NC=CN3
CHEMBL449284 ada1d_human Human No 6.4 EC50 = 364 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
219 1 0 1 2.4 C1C(CN2C1=NC=C2)C3=CC=CC=C3Cl
CHEMBL68230 ada1d_rat Rat Yes 5.4 EC50 = 3700 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
296 4 1 4 2.6 COC1=C(C=C(C=C1)CC2=NNC(=O)C3=CC=CC=C32)OC
CHEMBL68230 ada1d_rat Rat Yes 5.4 EC50 = 3700 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
296 4 1 4 2.6 COC1=C(C=C(C=C1)CC2=NNC(=O)C3=CC=CC=C32)OC
CHEMBL513691 ada1d_human Human No 6.4 EC50 = 391 Funct
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
262 2 0 3 1.7 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=CN=CN=C4
CHEMBL513691 ada1d_human Human No 6.4 EC50 = 391 Funct
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
262 2 0 3 1.7 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=CN=CN=C4
CHEMBL18436 ada1d_human Human No 6.4 EC50 = 398.1 Funct
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
298 7 2 4 1.9 CCCCN1C(=NC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL95333 ada1d_human Human No 6.4 EC50 = 398.1 Funct
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
286 4 2 3 1.8 C1CCN(CC1)C(=O)C2=CC=CC=C2NCC3=NCCN3
CHEMBL187933 ada1d_rat Rat No 4.4 EC50 = 40000 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
309 6 1 4 5.8 CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CCCO[N+](=O)[O-]
CHEMBL187933 ada1d_rat Rat No 4.4 EC50 = 40000 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
309 6 1 4 5.8 CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CCCO[N+](=O)[O-]
CHEMBL154298 ada1d_human Human No 7.4 EC50 = 41.7 Funct
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
252 4 2 3 1.5 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=CC=N3
CHEMBL207448 ada1d_rat Rat No 6.4 EC50 = 410 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
419 9 2 6 4.9 CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CCCN(C)CC2=NO[N+](=C2C(=O)N)[O-]
CHEMBL207448 ada1d_rat Rat No 6.4 EC50 = 410 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
419 9 2 6 4.9 CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CCCN(C)CC2=NO[N+](=C2C(=O)N)[O-]
CHEMBL188554 ada1d_rat Rat Yes 4.4 EC50 = 41000 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
105 2 0 3 1.4 CCCO[N+](=O)[O-]
CHEMBL188554 ada1d_rat Rat Yes 4.4 EC50 = 41000 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
105 2 0 3 1.4 CCCO[N+](=O)[O-]
CHEMBL72724 ada1d_human Human No 7.4 EC50 = 43.7 Funct
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
289 4 2 6 2.3 CSC1=C(C=C(C=C1)C(F)(F)F)NCC2=NCCN2
CHEMBL67457 ada1d_rat Rat Yes 6.4 EC50 = 430 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
285 2 0 2 3.4 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=C(C=C3)Cl
CHEMBL67457 ada1d_rat Rat Yes 6.4 EC50 = 430 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
285 2 0 2 3.4 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=C(C=C3)Cl
CHEMBL207183 ada1d_rat Rat No 5.4 EC50 = 4300 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
257 6 1 6 2.4 COC1=CC(=CC(=C1O)OC)CCCO[N+](=O)[O-]
CHEMBL207183 ada1d_rat Rat No 5.4 EC50 = 4300 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
257 6 1 6 2.4 COC1=CC(=CC(=C1O)OC)CCCO[N+](=O)[O-]
CHEMBL360593 ada1d_rat Rat No 7.4 EC50 = 44 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
461 5 1 8 4.5 CC1=C(C(=C2CCC(OC2=C1C)(C)COC3=NO[N+](=C3S(=O)(=O)C4=CC=CC=C4)[O-])C)O
CHEMBL360593 ada1d_rat Rat No 7.4 EC50 = 44 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
461 5 1 8 4.5 CC1=C(C(=C2CCC(OC2=C1C)(C)COC3=NO[N+](=C3S(=O)(=O)C4=CC=CC=C4)[O-])C)O
CHEMBL207189 ada1d_rat Rat Yes 5.4 EC50 = 4400 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
286 2 1 2 3.9 C1=CC=C2C(=C1)C=CC=C2CC3=NNC(=O)C4=CC=CC=C43
CHEMBL207189 ada1d_rat Rat Yes 5.4 EC50 = 4400 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
286 2 1 2 3.9 C1=CC=C2C(=C1)C=CC=C2CC3=NNC(=O)C4=CC=CC=C43
CHEMBL152693 ada1d_human Human No 7.3 EC50 = 49.0 Funct
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
271 4 2 3 2.6 CC1=C(SC=C1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL187824 ada1d_rat Rat No 5.3 EC50 = 4800 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
489 9 1 7 6.7 CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CCCOC2=NO[N+](=C2S(=O)(=O)C3=CC=CC=C3)[O-]
CHEMBL187824 ada1d_rat Rat No 5.3 EC50 = 4800 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
489 9 1 7 6.7 CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CCCOC2=NO[N+](=C2S(=O)(=O)C3=CC=CC=C3)[O-]
CHEMBL204632 ada1d_rat Rat Yes 5.3 EC50 = 4900 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
319 2 0 2 4.1 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC(=C(C=C3)Cl)Cl
CHEMBL204632 ada1d_rat Rat Yes 5.3 EC50 = 4900 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
319 2 0 2 4.1 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC(=C(C=C3)Cl)Cl
CHEMBL381054 ada1d_rat Rat No 4.3 EC50 = 49000 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
302 6 1 8 1.9 COC1=CC(=CC(=C1O)OC)CC(CO[N+](=O)[O-])[N+](=O)[O-]
CHEMBL381054 ada1d_rat Rat No 4.3 EC50 = 49000 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
302 6 1 8 1.9 COC1=CC(=CC(=C1O)OC)CC(CO[N+](=O)[O-])[N+](=O)[O-]
CHEMBL142784 ada1d_human Human No 8.3 EC50 = 5.0 Funct
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
242 4 1 3 1.6 C1CN=C(N1)COC2=CC=CC=C2C3=COC=C3
CHEMBL70691 ada1d_human Human No 8.3 EC50 = 5.0 Funct
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
251 5 2 4 1.4 COC1=CC(=C(C=C1)SC)NCC2=NCCN2
CHEMBL155326 ada1d_human Human No 8.3 EC50 = 5.0 Funct
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
242 4 2 4 1.0 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=CO3
CHEMBL208390 ada1d_rat Rat No 6.3 EC50 = 500 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
436 9 1 9 3.3 COC1=CC(=CC(=C1O)OC)CCCOC2=NO[N+](=C2S(=O)(=O)C3=CC=CC=C3)[O-]
CHEMBL208390 ada1d_rat Rat No 6.3 EC50 = 500 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
436 9 1 9 3.3 COC1=CC(=CC(=C1O)OC)CCCOC2=NO[N+](=C2S(=O)(=O)C3=CC=CC=C3)[O-]
CHEMBL207325 ada1d_rat Rat Yes 5.3 EC50 = 5300 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
324 5 0 4 3.1 CCN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC(=C(C=C3)OC)OC
CHEMBL207325 ada1d_rat Rat Yes 5.3 EC50 = 5300 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
324 5 0 4 3.1 CCN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC(=C(C=C3)OC)OC
CHEMBL379270 ada1d_rat Rat Yes 5.3 EC50 = 5400 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
352 7 0 4 4.0 CCCCN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC(=C(C=C3)OC)OC
CHEMBL379270 ada1d_rat Rat Yes 5.3 EC50 = 5400 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
352 7 0 4 4.0 CCCCN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC(=C(C=C3)OC)OC
CHEMBL376932 ada1d_rat Rat Yes 5.3 EC50 = 5500 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
282 3 1 3 3.1 CSC1=CC=C(C=C1)CC2=NNC(=O)C3=CC=CC=C32
CHEMBL376932 ada1d_rat Rat Yes 5.3 EC50 = 5500 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
282 3 1 3 3.1 CSC1=CC=C(C=C1)CC2=NNC(=O)C3=CC=CC=C32
CHEMBL136560 ada1d_rat Rat Yes 4.2 EC50 = 58000 Funct
Effective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uMEffective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uM
151 2 2 2 0.8 CC(C(C1=CC=CC=C1)O)N
CHEMBL357129 ada1d_human Human No 8.2 EC50 = 6.3 Funct
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
241 4 2 2 1.4 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CN3
CHEMBL18069 ada1d_human Human No 7.2 EC50 = 63.1 Funct
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
256 4 2 4 0.7 CN1C(=NC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL329928 ada1d_human Human No 7.2 EC50 = 63.1 Funct
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
247 6 2 4 1.7 CCOC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL450018 ada1d_human Human No 6.2 EC50 = 631.0 Funct
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
260 5 2 3 1.3 CCN(C)C(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL206100 ada1d_rat Rat Yes 5.2 EC50 = 6300 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
159 2 2 5 -0.9 C(C1=NO[N+](=C1C(=O)N)[O-])O
CHEMBL206100 ada1d_rat Rat Yes 5.2 EC50 = 6300 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
159 2 2 5 -0.9 C(C1=NO[N+](=C1C(=O)N)[O-])O
CHEMBL260720 ada1d_human Human No 6.2 EC50 = 634 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
264 2 2 2 2.5 CC1=C(C=NN1)C2=C3CCC(C3=CC=C2)C4=NC=CN4
CHEMBL260720 ada1d_human Human No 6.2 EC50 = 634 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
264 2 2 2 2.5 CC1=C(C=NN1)C2=C3CCC(C3=CC=C2)C4=NC=CN4
CHEMBL381054 ada1d_rat Rat No 6.2 EC50 = 640 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
302 6 1 8 1.9 COC1=CC(=CC(=C1O)OC)CC(CO[N+](=O)[O-])[N+](=O)[O-]
CHEMBL381054 ada1d_rat Rat No 6.2 EC50 = 640 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
302 6 1 8 1.9 COC1=CC(=CC(=C1O)OC)CC(CO[N+](=O)[O-])[N+](=O)[O-]
CHEMBL207967 ada1d_rat Rat No 4.2 EC50 = 65000 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
242 4 1 6 1.9 C1=CC(=CC=C1CC(CO[N+](=O)[O-])[N+](=O)[O-])O
CHEMBL207967 ada1d_rat Rat No 4.2 EC50 = 65000 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
242 4 1 6 1.9 C1=CC(=CC=C1CC(CO[N+](=O)[O-])[N+](=O)[O-])O
CHEMBL512289 ada1d_human Human No 6.2 EC50 = 656 Funct
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
261 2 0 2 2.3 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=CC=NC=C4
CHEMBL512289 ada1d_human Human No 6.2 EC50 = 656 Funct
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
261 2 0 2 2.3 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=CC=NC=C4
CHEMBL360593 ada1d_rat Rat No 6.2 EC50 = 670 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
461 5 1 8 4.5 CC1=C(C(=C2CCC(OC2=C1C)(C)COC3=NO[N+](=C3S(=O)(=O)C4=CC=CC=C4)[O-])C)O
CHEMBL360593 ada1d_rat Rat No 6.2 EC50 = 670 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
461 5 1 8 4.5 CC1=C(C(=C2CCC(OC2=C1C)(C)COC3=NO[N+](=C3S(=O)(=O)C4=CC=CC=C4)[O-])C)O
CHEMBL117248 ada1d_human Human No 8.1 EC50 = 7.9 Funct
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
221 4 2 3 1.4 CSC1=CC=CC=C1NCC2=NCCN2
CHEMBL512062 ada1d_human Human No 6.1 EC50 = 729 Funct
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
260 2 0 1 3.4 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL512062 ada1d_human Human No 6.1 EC50 = 729 Funct
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
260 2 0 1 3.4 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL465963 ada1d_human Human No 5.1 EC50 = 7360 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
184 1 0 1 1.8 C1C(CN2C1=NC=C2)C3=CC=CC=C3
CHEMBL465963 ada1d_human Human No 5.1 EC50 = 7360 Funct
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
184 1 0 1 1.8 C1C(CN2C1=NC=C2)C3=CC=CC=C3
CHEMBL207448 ada1d_rat Rat No 5.1 EC50 = 7400 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
419 9 2 6 4.9 CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CCCN(C)CC2=NO[N+](=C2C(=O)N)[O-]
CHEMBL207448 ada1d_rat Rat No 5.1 EC50 = 7400 Funct
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
419 9 2 6 4.9 CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CCCN(C)CC2=NO[N+](=C2C(=O)N)[O-]
CHEMBL61006 ada1d_rat Rat Yes 4.1 EC50 = 75857.8 Funct
Agonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aortaAgonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta
151 2 2 2 0.8 CC(C(C1=CC=CC=C1)O)N
CHEMBL325745 ada1d_human Human No 7.1 EC50 = 79.4 Funct
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
258 6 3 3 2.3 CCCNC(=O)C1=CC=CC=C1NCC2=CN=CN2
CHEMBL99362 ada1d_human Human Yes 7.1 EC50 = 79.4 Funct
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
246 5 3 3 1.1 CCNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL63976 ada1d_rat Rat Yes 6.1 EC50 = 790 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
271 2 1 2 3.2 C1=CC=C2C(=C1)C(=NNC2=O)CC3=CC=C(C=C3)Cl
CHEMBL63976 ada1d_rat Rat Yes 6.1 EC50 = 790 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
271 2 1 2 3.2 C1=CC=C2C(=C1)C(=NNC2=O)CC3=CC=C(C=C3)Cl
CHEMBL337862 ada1d_human Human No 6.1 EC50 = 794.3 Funct
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
251 4 2 2 2.6 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=CC=C3
CHEMBL156661 ada1d_human Human No 7.1 EC50 = 81.3 Funct
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
253 4 2 4 0.9 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=CC=N3
CHEMBL306792 ada1d_human Human No 8.0 EC50 = 9.1 Funct
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
239 4 2 4 1.5 CSC1=C(C=CC(=C1)F)NCC2=NCCN2
CHEMBL68362 ada1d_rat Rat Yes 6.0 EC50 = 930 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
294 2 0 4 2.6 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC4=C(C=C3)OCO4
CHEMBL206101 ada1d_rat Rat No 6.0 EC50 = 930 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
296 3 0 3 3.3 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=C(C=C3)SC
CHEMBL68362 ada1d_rat Rat Yes 6.0 EC50 = 930 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
294 2 0 4 2.6 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC4=C(C=C3)OCO4
CHEMBL206101 ada1d_rat Rat No 6.0 EC50 = 930 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
296 3 0 3 3.3 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=C(C=C3)SC
CHEMBL207170 ada1d_rat Rat Yes 5.0 EC50 = 9800 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
336 6 0 4 3.4 COC1=C(C=C(C=C1)CC2=NN(C(=O)C3=CC=CC=C32)CC=C)OC
CHEMBL207170 ada1d_rat Rat Yes 5.0 EC50 = 9800 Funct
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
336 6 0 4 3.4 COC1=C(C=C(C=C1)CC2=NN(C(=O)C3=CC=CC=C32)CC=C)OC
CHEMBL3809093 ada1d_human Human No 10.0 IC50 = 0.1 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
502 14 3 5 3.9 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=CC=CC=C3OCC4=CC=CC=C4
CHEMBL3809093 ada1d_human Human No 10.0 IC50 = 0.1 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
502 14 3 5 3.9 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=CC=CC=C3OCC4=CC=CC=C4
CHEMBL3808726 ada1d_human Human No 9.5 IC50 = 0.3 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
574 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Br)OCC(F)(F)F
CHEMBL3808726 ada1d_human Human No 9.5 IC50 = 0.3 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
574 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Br)OCC(F)(F)F
CHEMBL3810110 ada1d_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
444 12 3 6 2.5 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=CC(=C3)F)OC
CHEMBL3808896 ada1d_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
446 12 3 7 2.6 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)F)OC
CHEMBL3809319 ada1d_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
426 12 3 5 2.4 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=CC=CC=C3OC
CHEMBL3808999 ada1d_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
424 12 3 4 3.2 CCC1=CC=CC=C1OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3810110 ada1d_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
444 12 3 6 2.5 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=CC(=C3)F)OC
CHEMBL3808896 ada1d_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
446 12 3 7 2.6 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)F)OC
CHEMBL3809319 ada1d_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
426 12 3 5 2.4 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=CC=CC=C3OC
CHEMBL3808999 ada1d_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
424 12 3 4 3.2 CCC1=CC=CC=C1OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3808632 ada1d_human Human No 8.8 IC50 = 1.7 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
504 14 3 6 4.0 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC4=CC=CC=C4
CHEMBL3808632 ada1d_human Human No 8.8 IC50 = 1.7 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
504 14 3 6 4.0 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC4=CC=CC=C4
CHEMBL1909072 ada1d_human Human Yes 8.7 IC50 = 1.9 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
402 5 1 4 4.4 C1CN(CCC1C(=O)N)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL3742276 ada1d_human Human No 8.0 IC50 = 10.1 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
504 7 0 6 3.5 CS(=O)(=O)C1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3742276 ada1d_human Human No 8.0 IC50 = 10.1 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
504 7 0 6 3.5 CS(=O)(=O)C1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3809676 ada1d_human Human No 8.0 IC50 = 10.6 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
444 12 3 6 2.5 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)F)OC
CHEMBL3809676 ada1d_human Human No 8.0 IC50 = 10.6 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
444 12 3 6 2.5 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)F)OC
CHEMBL1945040 ada1d_human Human No 7.0 IC50 = 100 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
480 11 5 7 2.8 COC1=CC=CC=C1CNCC2=CC=C(C=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945032 ada1d_human Human No 7.0 IC50 = 100 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
517 11 6 6 3.8 CC1=CC=CC2=C1NC=C2CCNCC3=CC=C(C=C3)CCNCC(C4=C5C(=C(C=C4)O)NC(=O)S5)O
CHEMBL1945044 ada1d_human Human No 7.0 IC50 = 100 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
480 11 5 7 2.8 COC1=CC=CC(=C1)CNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945040 ada1d_human Human No 7.0 IC50 = 100 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
480 11 5 7 2.8 COC1=CC=CC=C1CNCC2=CC=C(C=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945032 ada1d_human Human No 7.0 IC50 = 100 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
517 11 6 6 3.8 CC1=CC=CC2=C1NC=C2CCNCC3=CC=C(C=C3)CCNCC(C4=C5C(=C(C=C4)O)NC(=O)S5)O
CHEMBL1945044 ada1d_human Human No 7.0 IC50 = 100 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
480 11 5 7 2.8 COC1=CC=CC(=C1)CNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945294 ada1d_human Human No 6.0 IC50 = 1000 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
414 8 4 6 2.3 C1CCN(C1)CC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945294 ada1d_human Human No 6.0 IC50 = 1000 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
414 8 4 6 2.3 C1CCN(C1)CC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL199397 ada1d_rat Rat Yes 5.0 IC50 = 10550 Funct
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
270 1 3 5 2.5 C1=CC2=C(C=C1O)C=C(C(=O)O2)C3=CC(=CC(=C3)O)O
CHEMBL199397 ada1d_rat Rat Yes 5.0 IC50 = 10550 Funct
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
270 1 3 5 2.5 C1=CC2=C(C=C1O)C=C(C(=O)O2)C3=CC(=CC(=C3)O)O
CHEMBL3739505 ada1d_human Human No 5.0 IC50 = 10630 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
444 6 0 5 4.4 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5F
CHEMBL3739505 ada1d_human Human No 5.0 IC50 = 10630 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
444 6 0 5 4.4 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5F
CHEMBL219916 ada1d_human Human Yes 6.0 IC50 = 1065 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
426 5 2 3 3.9 C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O
CHEMBL49 ada1d_human Human Yes 6.0 IC50 = 1077 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
386 6 0 6 2.6 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4
CHEMBL411 ada1d_human Human Yes 5.0 IC50 = 10826 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
268 4 2 2 5.1 CCC(=C(CC)C1=CC=C(C=C1)O)C2=CC=C(C=C2)O
CHEMBL411 ada1d_human Human Yes 5.0 IC50 = 10826 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
268 4 2 2 5.1 CCC(=C(CC)C1=CC=C(C=C1)O)C2=CC=C(C=C2)O
CHEMBL30008 ada1d_human Human Yes 6.0 IC50 = 1085 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
405 6 0 4 6.0 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
CHEMBL30008 ada1d_human Human Yes 6.0 IC50 = 1085 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
405 6 0 4 6.0 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
CHEMBL3739533 ada1d_human Human No 8.0 IC50 = 11.3 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
427 6 0 5 3.5 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=N5
CHEMBL3739533 ada1d_human Human No 8.0 IC50 = 11.3 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
427 6 0 5 3.5 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=N5
CHEMBL3810346 ada1d_human Human No 6.0 IC50 = 1107 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
530 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL3810346 ada1d_human Human No 6.0 IC50 = 1107 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
530 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL420683 ada1d_human Human No 6.0 IC50 = 1122.0 Funct
Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesBinding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranes
253 4 1 3 1.5 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CC=N3
CHEMBL1909065 ada1d_human Human No 6.0 IC50 = 1128 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
917 13 4 17 3.9 CC1CC(C(OC1C2CC(C(O2)C3(CCC(O3)C4(CCC5(O4)CC(C(C(O5)C(C)C6C(C(C(C(O6)(CC(=O)O)O)C)OC)OC)C)O)C)C)OC7CC(C(C(O7)C)OC)OC)(C)O)C
CHEMBL3739900 ada1d_human Human No 6.9 IC50 = 115.5 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
440 7 0 4 4.0 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)CC5=CC=CC=C5
CHEMBL3739900 ada1d_human Human No 6.9 IC50 = 115.5 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
440 7 0 4 4.0 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)CC5=CC=CC=C5
CHEMBL43064 ada1d_human Human Yes 5.9 IC50 = 1167 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
369 6 0 2 5.8 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL154298 ada1d_human Human No 6.9 IC50 = 117.5 Funct
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
252 4 2 3 1.5 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=CC=N3
CHEMBL1944695 ada1d_human Human No 7.9 IC50 = 12.6 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
464 11 5 6 3.3 C1=CC=C(C=C1)CCNCC2=CC=C(C=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1944695 ada1d_human Human No 7.9 IC50 = 12.6 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
464 11 5 6 3.3 C1=CC=C(C=C1)CCNCC2=CC=C(C=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL3742253 ada1d_human Human No 7.9 IC50 = 12.9 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
494 6 0 7 5.2 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)C(F)(F)F
CHEMBL3742253 ada1d_human Human No 7.9 IC50 = 12.9 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
494 6 0 7 5.2 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)C(F)(F)F
CHEMBL648 ada1d_human Human Yes 5.9 IC50 = 1215 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
266 3 0 2 3.6 CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL3740847 ada1d_human Human No 6.9 IC50 = 122 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
444 6 0 5 4.4 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)F
CHEMBL3740847 ada1d_human Human No 6.9 IC50 = 122 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
444 6 0 5 4.4 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)F
CHEMBL3741318 ada1d_human Human No 5.9 IC50 = 1235 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
456 7 0 5 4.3 COC1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3741318 ada1d_human Human No 5.9 IC50 = 1235 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
456 7 0 5 4.3 COC1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL1944691 ada1d_human Human No 6.9 IC50 = 125.9 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
482 11 5 7 3.4 C1=CC=C(C(=C1)CCNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O)F
CHEMBL1944691 ada1d_human Human No 6.9 IC50 = 125.9 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
482 11 5 7 3.4 C1=CC=C(C(=C1)CCNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O)F
CHEMBL564 ada1d_human Human Yes 7.9 IC50 = 13 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
284 4 0 3 4.5 CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31
CHEMBL564 ada1d_human Human Yes 7.9 IC50 = 13 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
284 4 0 3 4.5 CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31
CHEMBL3187195 ada1d_human Human Yes 7.9 IC50 = 13.4 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
496 13 3 9 3.6 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC(F)(F)F
CHEMBL3187195 ada1d_human Human Yes 7.9 IC50 = 13.4 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
496 13 3 9 3.6 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC(F)(F)F
CHEMBL3809840 ada1d_human Human No 5.9 IC50 = 1345 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
508 13 3 8 3.9 CC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3809840 ada1d_human Human No 5.9 IC50 = 1345 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
508 13 3 8 3.9 CC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL395110 ada1d_human Human Yes 6.9 IC50 = 137 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
310 2 0 3 5.6 CN1CCCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42
CHEMBL395110 ada1d_human Human Yes 6.9 IC50 = 137 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
310 2 0 3 5.6 CN1CCCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42
CHEMBL515170 ada1d_human Human No 4.9 IC50 = 13800 Funct
Inhibition of adrenergic Alpha-1D receptorInhibition of adrenergic Alpha-1D receptor
361 3 1 7 4.2 CCC1C(=O)NC2=C(C(=C(C=C2)F)F)C(O1)(C=CC3CC3)C(F)(F)F
CHEMBL515170 ada1d_human Human No 4.9 IC50 = 13800 Funct
Inhibition of adrenergic Alpha-1D receptorInhibition of adrenergic Alpha-1D receptor
361 3 1 7 4.2 CCC1C(=O)NC2=C(C(=C(C=C2)F)F)C(O1)(C=CC3CC3)C(F)(F)F
CHEMBL344294 ada1d_human Human No 5.9 IC50 = 1412.5 Funct
Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesBinding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranes
267 4 1 3 1.9 CC1=CC(=NC=C1)C2=CC=CC=C2OCC3=NCCN3
CHEMBL3809630 ada1d_human Human No 6.8 IC50 = 143.9 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
514 13 3 10 3.7 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)F)OCC(F)(F)F
CHEMBL3809630 ada1d_human Human No 6.8 IC50 = 143.9 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
514 13 3 10 3.7 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)F)OCC(F)(F)F
CHEMBL1306 ada1d_human Human Yes 4.8 IC50 = 14385 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
532 8 0 7 4.8 CC(C)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=NC=N4)C5=C(C=C(C=C5)Cl)Cl
CHEMBL1306 ada1d_human Human Yes 4.8 IC50 = 14385 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
532 8 0 7 4.8 CC(C)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=NC=N4)C5=C(C=C(C=C5)Cl)Cl
CHEMBL320419 ada1d_human Human No 5.8 IC50 = 1479.1 Funct
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
274 7 3 3 2.0 CCCCNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL3808408 ada1d_human Human No 7.8 IC50 = 15.8 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
428 12 3 6 2.5 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OC
CHEMBL3808408 ada1d_human Human No 7.8 IC50 = 15.8 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
428 12 3 6 2.5 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OC
CHEMBL3808572 ada1d_human Human No 7.8 IC50 = 15.9 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
494 13 3 8 3.5 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=CC=CC=C3OCC(F)(F)F
CHEMBL3808572 ada1d_human Human No 7.8 IC50 = 15.9 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
494 13 3 8 3.5 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=CC=CC=C3OCC(F)(F)F
CHEMBL104 ada1d_human Human Yes 4.8 IC50 = 15012 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
345 4 0 1 5.0 C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
CHEMBL104 ada1d_human Human Yes 4.8 IC50 = 15012 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
345 4 0 1 5.0 C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
CHEMBL24619 ada1d_rat Rat No 5.8 IC50 = 1550 Funct
Binding affinity was tested on cloned rat Alpha-1D adrenergic receptorBinding affinity was tested on cloned rat Alpha-1D adrenergic receptor
547 9 1 10 5.0 COC1=C(C=C(C=C1)CC2C3=CC(=C(C=C3CCN2C4=NC5=CC(=C(C=C5C(=N4)N)OC)OC)OC)OC)OC
CHEMBL3809500 ada1d_human Human No 5.8 IC50 = 1554 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
440 11 3 5 3.7 CC1=CC(=C(C(=C1)C)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)C
CHEMBL3809500 ada1d_human Human No 5.8 IC50 = 1554 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
440 11 3 5 3.7 CC1=CC(=C(C(=C1)C)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)C
CHEMBL1945037 ada1d_human Human No 6.8 IC50 = 158.5 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
478 12 5 6 3.7 C1=CC=C(C=C1)CCCNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945041 ada1d_human Human No 6.8 IC50 = 158.5 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
484 10 5 6 3.5 C1=CC=C(C(=C1)CNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O)Cl
CHEMBL1945289 ada1d_human Human No 6.8 IC50 = 158.5 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
480 11 5 7 2.8 COC1=CC=C(C=C1)CNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945037 ada1d_human Human No 6.8 IC50 = 158.5 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
478 12 5 6 3.7 C1=CC=C(C=C1)CCCNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945041 ada1d_human Human No 6.8 IC50 = 158.5 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
484 10 5 6 3.5 C1=CC=C(C(=C1)CNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O)Cl
CHEMBL1945289 ada1d_human Human No 6.8 IC50 = 158.5 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
480 11 5 7 2.8 COC1=CC=C(C=C1)CNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL3739762 ada1d_human Human No 7.8 IC50 = 16.7 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
451 6 0 5 4.0 [C-]#[N+]C1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3739762 ada1d_human Human No 7.8 IC50 = 16.7 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
451 6 0 5 4.0 [C-]#[N+]C1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3809794 ada1d_human Human No 6.8 IC50 = 162.2 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
504 12 3 5 3.1 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)Br)OC
CHEMBL3809794 ada1d_human Human No 6.8 IC50 = 162.2 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
504 12 3 5 3.1 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)Br)OC
CHEMBL3809532 ada1d_human Human No 5.8 IC50 = 1621 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
426 11 3 5 3.3 CC1=C(C(=CC=C1)C)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL3809532 ada1d_human Human No 5.8 IC50 = 1621 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
426 11 3 5 3.3 CC1=C(C(=CC=C1)C)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL3739542 ada1d_human Human No 6.8 IC50 = 163.7 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
494 6 0 7 5.2 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5C(F)(F)F
CHEMBL3739542 ada1d_human Human No 6.8 IC50 = 163.7 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
494 6 0 7 5.2 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5C(F)(F)F
CHEMBL97044 ada1d_human Human No 5.8 IC50 = 1698.2 Funct
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
258 5 3 3 1.3 C1CC1NC(=O)C2=CC=CC=C2NCC3=NCCN3
CHEMBL611 ada1d_human Human Yes 7.8 IC50 = 17 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL611 ada1d_human Human Yes 7.8 IC50 = 17 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL844 ada1d_human Human Yes 5.8 IC50 = 1720 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
292 2 2 3 0.6 C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br
CHEMBL844 ada1d_human Human Yes 5.8 IC50 = 1720 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
292 2 2 3 0.6 C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br
CHEMBL3741658 ada1d_human Human No 5.8 IC50 = 1758 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
426 6 0 4 4.3 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5
CHEMBL3741658 ada1d_human Human No 5.8 IC50 = 1758 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
426 6 0 4 4.3 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5
CHEMBL305660 ada1d_human Human Yes 5.8 IC50 = 1771.2 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
470 10 0 3 7.2 CC(C)(C)C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL305660 ada1d_human Human Yes 5.8 IC50 = 1771.2 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
470 10 0 3 7.2 CC(C)(C)C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL415 ada1d_human Human Yes 6.8 IC50 = 180 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
315 4 0 2 5.2 CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl
CHEMBL643 ada1d_human Human Yes 6.7 IC50 = 183 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
284 3 0 3 4.8 CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C
CHEMBL643 ada1d_human Human Yes 6.7 IC50 = 183 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
284 3 0 3 4.8 CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C
CHEMBL3739513 ada1d_human Human No 5.7 IC50 = 1862 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
456 7 0 5 4.3 COC1=CC=C(C=C1)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3739513 ada1d_human Human No 5.7 IC50 = 1862 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
456 7 0 5 4.3 COC1=CC=C(C=C1)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL1358628 ada1d_human Human Yes 6.7 IC50 = 189 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL1729 ada1d_human Human Yes 6.7 IC50 = 189 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL74656 ada1d_human Human Yes 6.7 IC50 = 189 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL1358628 ada1d_human Human Yes 6.7 IC50 = 189 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL1729 ada1d_human Human Yes 6.7 IC50 = 189 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL74656 ada1d_human Human Yes 6.7 IC50 = 189 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL117248 ada1d_human Human No 7.7 IC50 = 19.5 Funct
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
221 4 2 3 1.4 CSC1=CC=CC=C1NCC2=NCCN2
CHEMBL3808417 ada1d_human Human No 6.7 IC50 = 196.8 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
462 12 3 6 3.2 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)Cl)OC
CHEMBL3808417 ada1d_human Human No 6.7 IC50 = 196.8 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
462 12 3 6 3.2 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)Cl)OC
CHEMBL1945039 ada1d_human Human No 6.7 IC50 = 199.5 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
480 11 5 7 2.8 COC1=CC=CC=C1CNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945033 ada1d_human Human No 6.7 IC50 = 199.5 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
465 11 5 7 2.3 C1=CC=NC(=C1)CCNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945035 ada1d_human Human No 6.7 IC50 = 199.5 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
482 11 5 7 3.4 C1=CC=C(C(=C1)CCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O)CNCCC4=CC=CC=C4F
CHEMBL1945039 ada1d_human Human No 6.7 IC50 = 199.5 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
480 11 5 7 2.8 COC1=CC=CC=C1CNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945033 ada1d_human Human No 6.7 IC50 = 199.5 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
465 11 5 7 2.3 C1=CC=NC(=C1)CCNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945035 ada1d_human Human No 6.7 IC50 = 199.5 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
482 11 5 7 3.4 C1=CC=C(C(=C1)CCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O)CNCCC4=CC=CC=C4F
CHEMBL319553 ada1d_human Human No 5.7 IC50 = 1995.3 Funct
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
261 6 2 4 2.1 CC(C)OC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL165 ada1d_rat Rat Yes 4.7 IC50 = 19950 Funct
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
228 2 3 3 3.1 C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O
CHEMBL165 ada1d_rat Rat Yes 4.7 IC50 = 19950 Funct
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
228 2 3 3 3.1 C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O
CHEMBL3582270 ada1d_human Human No 8.7 IC50 = 2.2 Funct
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
600 8 1 12 3.3 CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)N3C=C(N=N3)C(=O)N4CCN(CC4)C5=NC6=CC(=C(C=C6C(=N5)N)OC)OC
CHEMBL3582270 ada1d_human Human No 8.7 IC50 = 2.2 Funct
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
600 8 1 12 3.3 CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)N3C=C(N=N3)C(=O)N4CCN(CC4)C5=NC6=CC(=C(C=C6C(=N5)N)OC)OC
CHEMBL3809248 ada1d_human Human No 8.6 IC50 = 2.6 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
440 13 3 5 2.8 CCOC1=CC=CC=C1OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3809248 ada1d_human Human No 8.6 IC50 = 2.6 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
440 13 3 5 2.8 CCOC1=CC=CC=C1OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL470432 ada1d_human Human No 6.7 IC50 = 204.2 Funct
Displacement of [3H]prazosin form human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]prazosin form human recombinant Alpha-1D adrenergic receptor
343 5 0 4 5.2 CCCN1CCC(CC1)COC2=NC3=C(C(=CS3)C)N4C2=CC=C4
CHEMBL470432 ada1d_human Human No 6.7 IC50 = 204.2 Funct
Displacement of [3H]prazosin form human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]prazosin form human recombinant Alpha-1D adrenergic receptor
343 5 0 4 5.2 CCCN1CCC(CC1)COC2=NC3=C(C(=CS3)C)N4C2=CC=C4
CHEMBL7568 ada1d_human Human Yes 5.7 IC50 = 2065 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
400 9 1 4 6.0 CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC
CHEMBL7568 ada1d_human Human Yes 5.7 IC50 = 2065 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
400 9 1 4 6.0 CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC
CHEMBL3808511 ada1d_human Human No 7.7 IC50 = 21.7 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
492 11 3 5 3.2 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)F)Br
CHEMBL3808511 ada1d_human Human No 7.7 IC50 = 21.7 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
492 11 3 5 3.2 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)F)Br
CHEMBL430717 ada1d_rat Rat No 7.6 IC50 = 22.9 Funct
Binding affinity was tested on cloned rat Alpha-1D adrenergic receptorBinding affinity was tested on cloned rat Alpha-1D adrenergic receptor
496 8 1 9 3.8 CC(C)C1=C(C(=CC=C1)OC)OCC(=O)N2CCN(CC2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL2203713 ada1d_human Human No 5.7 IC50 = 2200 Funct
Inhibition of alpha1D adrenergic receptorInhibition of alpha1D adrenergic receptor
326 3 2 4 2.9 C1CNCCC1N2CCC3=C2C=CC(=C3)N=C(C4=CC=CS4)N
CHEMBL3740351 ada1d_human Human No 6.6 IC50 = 239.9 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
470 8 0 5 4.6 CCOC1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3740351 ada1d_human Human No 6.6 IC50 = 239.9 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
470 8 0 5 4.6 CCOC1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL384790 ada1d_rat Rat No 7.6 IC50 = 24.6 Funct
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
1162 33 6 20 6.2 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=C(C=C4)CNCCCCCCNCCSSCCNCCCCCCNCC5=CC=C(C=C5)C(=O)N6CCN(CC6)C7=NC8=CC(=C(C=C8C(=N7)N)OC)OC)N)OC
CHEMBL1945299 ada1d_human Human No 7.6 IC50 = 25.1 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
494 12 5 7 3.3 COC1=CC=CC=C1CNCCC2=CC(=CC=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945298 ada1d_human Human No 7.6 IC50 = 25.1 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
498 12 5 8 3.1 C1=CC=C(C(=C1)CCNCC2=CC(=CC=C2)OCCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O)F
CHEMBL1945034 ada1d_human Human No 7.6 IC50 = 25.1 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
465 11 5 7 2.3 C1=CC=NC(=C1)CCNCC2=CC=C(C=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945299 ada1d_human Human No 7.6 IC50 = 25.1 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
494 12 5 7 3.3 COC1=CC=CC=C1CNCCC2=CC(=CC=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945298 ada1d_human Human No 7.6 IC50 = 25.1 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
498 12 5 8 3.1 C1=CC=C(C(=C1)CCNCC2=CC(=CC=C2)OCCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O)F
CHEMBL1945034 ada1d_human Human No 7.6 IC50 = 25.1 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
465 11 5 7 2.3 C1=CC=NC(=C1)CCNCC2=CC=C(C=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945038 ada1d_human Human No 6.6 IC50 = 251.2 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
479 12 5 7 2.6 C1=CC=NC(=C1)CCCNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945291 ada1d_human Human No 6.6 IC50 = 251.2 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
494 11 4 7 3.3 CN(CC1=CC=CC(=C1)CCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O)CC4=CC=CC=C4OC
CHEMBL1945038 ada1d_human Human No 6.6 IC50 = 251.2 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
479 12 5 7 2.6 C1=CC=NC(=C1)CCCNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945291 ada1d_human Human No 6.6 IC50 = 251.2 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
494 11 4 7 3.3 CN(CC1=CC=CC(=C1)CCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O)CC4=CC=CC=C4OC
CHEMBL356605 ada1d_human Human No 6.6 IC50 = 257.0 Funct
Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesBinding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranes
253 4 1 3 1.5 C1CN=C(N1)COC2=CC=CC=C2C3=CN=CC=C3
CHEMBL263289 ada1d_rat Rat No 7.6 IC50 = 26.9 Funct
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
1162 33 6 20 6.2 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CC=C4CNCCCCCCNCCSSCCNCCCCCCNCC5=CC=CC=C5C(=O)N6CCN(CC6)C7=NC8=CC(=C(C=C8C(=N7)N)OC)OC)N)OC
CHEMBL1282 ada1d_human Human Yes 5.6 IC50 = 2621 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
240 2 1 3 2.6 CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N
CHEMBL1282 ada1d_human Human Yes 5.6 IC50 = 2621 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
240 2 1 3 2.6 CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N
CHEMBL621 ada1d_human Human Yes 6.6 IC50 = 265 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
372 5 0 4 2.8 C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl
CHEMBL141343 ada1d_human Human Yes 4.6 IC50 = 26710 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
521 5 1 8 5.4 CC1=C(C(=C2CCC(OC2=C1C)(C)CN3CCN(CC3)C4=NC(=NC(=C4)N5CCCC5)N6CCCC6)C)O
CHEMBL445 ada1d_human Human Yes 6.6 IC50 = 273 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
263 3 1 1 4.5 CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL445 ada1d_human Human Yes 6.6 IC50 = 273 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
263 3 1 1 4.5 CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL3809175 ada1d_human Human No 6.6 IC50 = 274 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
506 12 3 6 3.2 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)Br)OC
CHEMBL3809175 ada1d_human Human No 6.6 IC50 = 274 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
506 12 3 6 3.2 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)Br)OC
CHEMBL117381 ada1d_human Human No 6.5 IC50 = 295.1 Funct
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
242 4 2 4 1.0 C1CN=C(N1)CNC2=CC=CC=C2C3=CN=CO3
CHEMBL707 ada1d_human Human Yes 8.5 IC50 = 3.4 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL707 ada1d_human Human Yes 8.5 IC50 = 3.4 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL71 ada1d_human Human Yes 8.4 IC50 = 4.0 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
319 4 0 3 5.2 CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
CHEMBL71 ada1d_human Human Yes 8.4 IC50 = 4.0 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
319 4 0 3 5.2 CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
CHEMBL91 ada1d_human Human Yes 5.5 IC50 = 3046 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
416 6 0 2 5.3 C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
CHEMBL1113 ada1d_human Human Yes 6.5 IC50 = 306 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
314 1 1 3 2.6 C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
CHEMBL3742103 ada1d_human Human No 7.5 IC50 = 31.3 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
474 6 0 4 5.3 CC1=C(C=C(C=C1)Cl)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3742103 ada1d_human Human No 7.5 IC50 = 31.3 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
474 6 0 4 5.3 CC1=C(C=C(C=C1)Cl)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3810401 ada1d_human Human No 7.5 IC50 = 31.6 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
460 12 3 5 3.0 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)Cl)OC
CHEMBL3810401 ada1d_human Human No 7.5 IC50 = 31.6 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
460 12 3 5 3.0 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)Cl)OC
CHEMBL1945036 ada1d_human Human No 7.5 IC50 = 31.6 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
478 11 5 6 3.7 CC(CNCC1=CC=C(C=C1)CCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O)C4=CC=CC=C4
CHEMBL1945290 ada1d_human Human No 7.5 IC50 = 31.6 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
494 12 5 7 3.2 CCOC1=CC=CC=C1CNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945036 ada1d_human Human No 7.5 IC50 = 31.6 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
478 11 5 6 3.7 CC(CNCC1=CC=C(C=C1)CCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O)C4=CC=CC=C4
CHEMBL1945290 ada1d_human Human No 7.5 IC50 = 31.6 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
494 12 5 7 3.2 CCOC1=CC=CC=C1CNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945043 ada1d_human Human No 6.5 IC50 = 316.2 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
451 10 5 7 1.8 C1=CC=NC(=C1)CNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945043 ada1d_human Human No 6.5 IC50 = 316.2 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
451 10 5 7 1.8 C1=CC=NC(=C1)CNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1626 ada1d_human Human Yes 7.5 IC50 = 32 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
344 6 0 2 5.0 CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C
CHEMBL1626 ada1d_human Human Yes 7.5 IC50 = 32 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
344 6 0 2 5.0 CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C
CHEMBL13789 ada1d_human Human No 6.5 IC50 = 323.6 Funct
Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesBinding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranes
252 4 1 2 2.5 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CC=C3
CHEMBL549 ada1d_human Human Yes 5.5 IC50 = 3289 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
324 5 0 4 3.2 CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F
CHEMBL728 ada1d_human Human Yes 7.5 IC50 = 34 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
374 4 0 4 4.9 CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL3582271 ada1d_human Human No 7.5 IC50 = 34 Funct
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
679 6 4 12 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=S)NC4=CC(=C(C=C4)C5=C6C=CC(=O)C=C6OC7=C5C=CC(=C7)O)C(=O)O)N)OC
CHEMBL728 ada1d_human Human Yes 7.5 IC50 = 34 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
374 4 0 4 4.9 CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL3740019 ada1d_human Human No 6.5 IC50 = 343.6 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
440 6 0 4 4.6 CC1=CC=C(C=C1)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3740019 ada1d_human Human No 6.5 IC50 = 343.6 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
440 6 0 4 4.6 CC1=CC=C(C=C1)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL154023 ada1d_human Human No 6.5 IC50 = 346.7 Funct
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
256 4 2 4 1.4 CC1=C(OC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL3810187 ada1d_human Human No 5.5 IC50 = 3464 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
524 14 3 9 4.4 CCC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL3810187 ada1d_human Human No 5.5 IC50 = 3464 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
524 14 3 9 4.4 CCC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL42 ada1d_human Human Yes 7.5 IC50 = 35 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL3741483 ada1d_human Human No 7.5 IC50 = 35.2 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
460 6 0 4 4.9 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL3741483 ada1d_human Human No 7.5 IC50 = 35.2 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
460 6 0 4 4.9 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL3742198 ada1d_human Human No 7.4 IC50 = 36.6 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
460 6 0 4 4.9 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5Cl
CHEMBL3742198 ada1d_human Human No 7.4 IC50 = 36.6 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
460 6 0 4 4.9 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5Cl
CHEMBL3808878 ada1d_human Human No 7.4 IC50 = 37.4 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
412 11 3 5 2.9 CC1=CC=CC=C1OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL3808878 ada1d_human Human No 7.4 IC50 = 37.4 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
412 11 3 5 2.9 CC1=CC=CC=C1OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL3809314 ada1d_human Human No 5.4 IC50 = 3717 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
508 13 3 8 3.9 CC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3809314 ada1d_human Human No 5.4 IC50 = 3717 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
508 13 3 8 3.9 CC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3808717 ada1d_human Human No 5.4 IC50 = 3794 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
522 14 3 8 4.3 CCC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3808717 ada1d_human Human No 5.4 IC50 = 3794 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
522 14 3 8 4.3 CCC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL155327 ada1d_human Human No 7.4 IC50 = 38.0 Funct
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
242 4 2 4 1.0 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=NO3
CHEMBL200198 ada1d_rat Rat No 4.4 IC50 = 38920 Funct
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
270 1 3 5 2.5 C1=CC2=C(C=C1O)OC(=O)C(=C2)C3=CC(=CC(=C3)O)O
CHEMBL200198 ada1d_rat Rat No 4.4 IC50 = 38920 Funct
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
270 1 3 5 2.5 C1=CC2=C(C=C1O)OC(=O)C(=C2)C3=CC(=CC(=C3)O)O
CHEMBL1945297 ada1d_human Human No 7.4 IC50 = 39.8 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
547 11 5 6 5.0 CC(CC1=CC(=CC=C1)CNCCC2=C(C=CC=C2Cl)Cl)NCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945296 ada1d_human Human No 7.4 IC50 = 39.8 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
547 12 5 6 4.9 C1=CC(=CC(=C1)CNCCC2=C(C=CC=C2Cl)Cl)CCCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945297 ada1d_human Human No 7.4 IC50 = 39.8 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
547 11 5 6 5.0 CC(CC1=CC(=CC=C1)CNCCC2=C(C=CC=C2Cl)Cl)NCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945296 ada1d_human Human No 7.4 IC50 = 39.8 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
547 12 5 6 4.9 C1=CC(=CC(=C1)CNCCC2=C(C=CC=C2Cl)Cl)CCCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL277375 ada1d_human Human No 7.4 IC50 = 39.8 Funct
Inhibitory concentration against radioligand binding to human aAlpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsInhibitory concentration against radioligand binding to human aAlpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
241 4 3 3 0.9 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=NN3
CHEMBL21731 ada1d_human Human Yes 6.4 IC50 = 397 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
277 4 1 1 4.6 CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24
CHEMBL1945503 ada1d_human Human No 6.4 IC50 = 398.1 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
459 11 5 6 1.9 C1=CC=NC(=C1)CCNCC2=CC=CC(=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O
CHEMBL1945031 ada1d_human Human No 6.4 IC50 = 398.1 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
517 11 6 6 3.8 CC1=CC=CC2=C1NC=C2CCNCC3=CC=CC(=C3)CCNCC(C4=C5C(=C(C=C4)O)NC(=O)S5)O
CHEMBL1945503 ada1d_human Human No 6.4 IC50 = 398.1 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
459 11 5 6 1.9 C1=CC=NC(=C1)CCNCC2=CC=CC(=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O
CHEMBL1945031 ada1d_human Human No 6.4 IC50 = 398.1 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
517 11 6 6 3.8 CC1=CC=CC2=C1NC=C2CCNCC3=CC=CC(=C3)CCNCC(C4=C5C(=C(C=C4)O)NC(=O)S5)O
CHEMBL199788 ada1d_rat Rat Yes 4.4 IC50 = 39800 Funct
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
298 3 1 5 3.1 COC1=CC(=CC(=C1)C2=CC3=C(C=C(C=C3)O)OC2=O)OC
CHEMBL199788 ada1d_rat Rat Yes 4.4 IC50 = 39800 Funct
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
298 3 1 5 3.1 COC1=CC(=CC(=C1)C2=CC3=C(C=C(C=C3)O)OC2=O)OC
CHEMBL155326 ada1d_human Human No 7.4 IC50 = 40.7 Funct
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
242 4 2 4 1.0 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=CO3
CHEMBL3810005 ada1d_human Human No 6.4 IC50 = 410.2 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
530 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL3810005 ada1d_human Human No 6.4 IC50 = 410.2 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
530 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL143562 ada1d_human Human No 6.4 IC50 = 416.9 Funct
Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesBinding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranes
256 4 1 3 2.0 CC1=C(OC=C1)C2=CC=CC=C2OCC3=NCCN3
CHEMBL156661 ada1d_human Human No 6.4 IC50 = 416.9 Funct
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
253 4 2 4 0.9 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=CC=N3
CHEMBL351542 ada1d_human Human No 7.4 IC50 = 42.7 Funct
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
232 5 2 4 1.0 CON=CC1=CC=CC=C1NCC2=NCCN2
CHEMBL199904 ada1d_rat Rat No 4.4 IC50 = 42650 Funct
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
312 4 0 5 3.5 COC1=CC2=C(C=C1)OC(=O)C(=C2)C3=CC(=CC(=C3)OC)OC
CHEMBL199904 ada1d_rat Rat No 4.4 IC50 = 42650 Funct
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
312 4 0 5 3.5 COC1=CC2=C(C=C1)OC(=O)C(=C2)C3=CC(=CC(=C3)OC)OC
CHEMBL3808595 ada1d_human Human No 6.4 IC50 = 436.2 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
494 11 3 6 3.4 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)F)Br
CHEMBL3808595 ada1d_human Human No 6.4 IC50 = 436.2 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
494 11 3 6 3.4 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)F)Br
CHEMBL3582272 ada1d_human Human No 7.3 IC50 = 45.2 Funct
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
586 9 1 12 3.4 CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)N3C=C(N=N3)CN4CCN(CC4)C5=NC6=CC(=C(C=C6C(=N5)N)OC)OC
CHEMBL3808981 ada1d_human Human No 6.3 IC50 = 457.1 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
530 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL3808981 ada1d_human Human No 6.3 IC50 = 457.1 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
530 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL3810198 ada1d_human Human No 6.3 IC50 = 457.5 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
426 12 3 5 3.4 CCC1=CC=CC=C1OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL3810198 ada1d_human Human No 6.3 IC50 = 457.5 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
426 12 3 5 3.4 CCC1=CC=CC=C1OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL3809490 ada1d_human Human No 6.3 IC50 = 474.3 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
508 13 3 8 3.9 CC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3809490 ada1d_human Human No 6.3 IC50 = 474.3 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
508 13 3 8 3.9 CC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL1535 ada1d_human Human Yes 5.3 IC50 = 4772 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
336 9 2 4 3.6 CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO
CHEMBL1535 ada1d_human Human Yes 5.3 IC50 = 4772 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
336 9 2 4 3.6 CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO
CHEMBL1403281 ada1d_human Human Yes 7.3 IC50 = 48 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
576 5 3 6 2.7 CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=CNC7=CC=CC(=C67)C5=C4)C)O
CHEMBL1403281 ada1d_human Human Yes 7.3 IC50 = 48 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
576 5 3 6 2.7 CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=CNC7=CC=CC(=C67)C5=C4)C)O
CHEMBL3809600 ada1d_human Human No 7.3 IC50 = 49.6 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
446 12 3 7 2.6 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)F)OC
CHEMBL3809600 ada1d_human Human No 7.3 IC50 = 49.6 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
446 12 3 7 2.6 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)F)OC
CHEMBL3741161 ada1d_human Human No 6.3 IC50 = 493.3 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
462 6 0 6 4.5 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=C(C=C(C=C5)F)F
CHEMBL3741161 ada1d_human Human No 6.3 IC50 = 493.3 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
462 6 0 6 4.5 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=C(C=C(C=C5)F)F
CHEMBL83 ada1d_human Human Yes 5.3 IC50 = 4982 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
372 8 0 2 7.1 CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
CHEMBL83 ada1d_human Human Yes 5.3 IC50 = 4982 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
372 8 0 2 7.1 CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
CHEMBL479 ada1d_human Human Yes 8.2 IC50 = 5.9 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
371 4 0 4 5.9 CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC
CHEMBL479 ada1d_human Human Yes 8.2 IC50 = 5.9 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
371 4 0 4 5.9 CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC
CHEMBL1944690 ada1d_human Human No 7.3 IC50 = 50.1 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
498 11 5 6 4.0 C1=CC=C(C(=C1)CCNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O)Cl
CHEMBL1944692 ada1d_human Human No 7.3 IC50 = 50.1 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
482 11 5 7 3.4 C1=CC=C(C(=C1)CCNCC2=CC=C(C=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O)F
CHEMBL1944690 ada1d_human Human No 7.3 IC50 = 50.1 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
498 11 5 6 4.0 C1=CC=C(C(=C1)CCNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O)Cl
CHEMBL1944692 ada1d_human Human No 7.3 IC50 = 50.1 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
482 11 5 7 3.4 C1=CC=C(C(=C1)CCNCC2=CC=C(C=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O)F
CHEMBL1945292 ada1d_human Human No 6.3 IC50 = 501.2 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
418 11 5 7 1.2 COCCNCC1=CC=CC(=C1)CCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1945300 ada1d_human Human No 6.3 IC50 = 501.2 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
421 12 5 5 3.2 C1=CC=C(C=C1)CCNCC2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)CO)O
CHEMBL1945292 ada1d_human Human No 6.3 IC50 = 501.2 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
418 11 5 7 1.2 COCCNCC1=CC=CC(=C1)CCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1945300 ada1d_human Human No 6.3 IC50 = 501.2 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
421 12 5 5 3.2 C1=CC=C(C=C1)CCNCC2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)CO)O
CHEMBL17851 ada1d_human Human No 6.3 IC50 = 501.2 Funct
Inhibitory concentration against radioligand binding to human Alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsInhibitory concentration against radioligand binding to human Alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
255 4 2 3 0.9 CN1C(=CC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL122621 ada1d_rat Rat No 5.3 IC50 = 5011.9 Funct
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
591 27 4 8 5.0 COC1=CC=CC(=C1)CNCCCCCCNCCSSCCNCCCCCCNCC2=CC=CC=C2OC
CHEMBL318544 ada1d_human Human No 6.3 IC50 = 512.9 Funct
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
260 6 3 3 1.7 CCCNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL3809781 ada1d_human Human No 5.3 IC50 = 5208 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
442 11 3 7 2.4 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC4=C(C=C3)OCO4
CHEMBL3809781 ada1d_human Human No 5.3 IC50 = 5208 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
442 11 3 7 2.4 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC4=C(C=C3)OCO4
CHEMBL199527 ada1d_rat Rat No 4.3 IC50 = 52480 Funct
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
312 4 0 5 3.5 COC1=CC2=C(C=C1)C=C(C(=O)O2)C3=CC(=CC(=C3)OC)OC
CHEMBL199527 ada1d_rat Rat No 4.3 IC50 = 52480 Funct
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
312 4 0 5 3.5 COC1=CC2=C(C=C1)C=C(C(=O)O2)C3=CC(=CC(=C3)OC)OC
CHEMBL357129 ada1d_human Human No 7.3 IC50 = 53.7 Funct
Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesBinding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranes
241 4 2 2 1.4 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CN3
CHEMBL13789 ada1d_human Human No 6.3 IC50 = 549.5 Funct
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
252 4 1 2 2.5 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CC=C3
CHEMBL142635 ada1d_human Human Yes 7.3 IC50 = 55.2 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
392 7 1 5 4.1 COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
CHEMBL142635 ada1d_human Human Yes 7.3 IC50 = 55.2 Funct
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
392 7 1 5 4.1 COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
CHEMBL142635 ada1d_human Human Yes 7.3 IC50 = 55.2 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
392 7 1 5 4.1 COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
CHEMBL493091 ada1d_human Human No 6.3 IC50 = 560 Funct
Inhibition of cloned adrenergic Alpha-1D receptorInhibition of cloned adrenergic Alpha-1D receptor
473 9 2 3 4.0 CN(C)CCCOC1=C(C=C(C=C1)CCNC(=O)C2=CC(=CN2)Br)Br
CHEMBL493091 ada1d_human Human No 6.3 IC50 = 560 Funct
Inhibition of cloned adrenergic Alpha-1D receptorInhibition of cloned adrenergic Alpha-1D receptor
473 9 2 3 4.0 CN(C)CCCOC1=C(C=C(C=C1)CCNC(=O)C2=CC(=CN2)Br)Br
CHEMBL118055 ada1d_human Human Yes 7.2 IC50 = 57.5 Funct
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
219 4 2 3 2.1 CSC1=CC=CC=C1NCC2=CN=CN2
CHEMBL3810220 ada1d_human Human No 7.2 IC50 = 60.6 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
442 12 3 6 2.9 CC1=CC(=C(C=C1)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)OC
CHEMBL3810220 ada1d_human Human No 7.2 IC50 = 60.6 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
442 12 3 6 2.9 CC1=CC(=C(C=C1)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)OC
CHEMBL1947157 ada1d_human Human No 7.2 IC50 = 63.1 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
532 11 5 6 4.6 C1=CC(=CC(=C1)CNCCC2=C(C=CC=C2Cl)Cl)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1947157 ada1d_human Human No 7.2 IC50 = 63.1 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
532 11 5 6 4.6 C1=CC(=CC(=C1)CNCCC2=C(C=CC=C2Cl)Cl)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL3741260 ada1d_human Human No 7.2 IC50 = 63.5 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
451 6 0 5 4.0 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)C#N
CHEMBL3741260 ada1d_human Human No 7.2 IC50 = 63.5 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
451 6 0 5 4.0 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)C#N
CHEMBL1945293 ada1d_human Human No 6.2 IC50 = 631.0 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
418 11 5 7 1.2 COCCNCC1=CC=C(C=C1)CCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1945293 ada1d_human Human No 6.2 IC50 = 631.0 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
418 11 5 7 1.2 COCCNCC1=CC=C(C=C1)CCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL421011 ada1d_human Human No 5.2 IC50 = 6606.9 Funct
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
274 6 2 3 1.7 CCN(CC)C(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL450018 ada1d_human Human No 5.2 IC50 = 6760.8 Funct
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
260 5 2 3 1.3 CCN(C)C(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL1944694 ada1d_human Human No 8.1 IC50 = 7.9 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
494 12 5 7 3.3 COC1=CC=CC=C1CCNCC2=CC=C(C=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1944694 ada1d_human Human No 8.1 IC50 = 7.9 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
494 12 5 7 3.3 COC1=CC=CC=C1CCNCC2=CC=C(C=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL3741079 ada1d_human Human No 5.1 IC50 = 7426 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
504 6 0 4 5.0 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Br
CHEMBL3741079 ada1d_human Human No 5.1 IC50 = 7426 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
504 6 0 4 5.0 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Br
CHEMBL296419 ada1d_human Human Yes 6.1 IC50 = 769 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
459 8 1 5 6.0 COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
CHEMBL296419 ada1d_human Human Yes 6.1 IC50 = 769 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
459 8 1 5 6.0 COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
CHEMBL1944689 ada1d_human Human No 7.1 IC50 = 79.4 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
532 11 5 6 4.6 C1=CC(=C(C(=C1)Cl)CCNCC2=CC=C(C=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O)Cl
CHEMBL1945504 ada1d_human Human No 7.1 IC50 = 79.4 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
480 11 5 7 2.8 COC1=CC=CC=C1CNCC2=CC=C(C=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945042 ada1d_human Human No 7.1 IC50 = 79.4 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
468 10 5 7 3.0 C1=CC=C(C(=C1)CNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O)F
CHEMBL1944693 ada1d_human Human No 7.1 IC50 = 79.4 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
494 12 5 7 3.3 COC1=CC=CC=C1CCNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1944689 ada1d_human Human No 7.1 IC50 = 79.4 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
532 11 5 6 4.6 C1=CC(=C(C(=C1)Cl)CCNCC2=CC=C(C=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O)Cl
CHEMBL1945504 ada1d_human Human No 7.1 IC50 = 79.4 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
480 11 5 7 2.8 COC1=CC=CC=C1CNCC2=CC=C(C=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1945042 ada1d_human Human No 7.1 IC50 = 79.4 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
468 10 5 7 3.0 C1=CC=C(C(=C1)CNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O)F
CHEMBL1944693 ada1d_human Human No 7.1 IC50 = 79.4 Funct
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
494 12 5 7 3.3 COC1=CC=CC=C1CCNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1201216 ada1d_human Human Yes 8.1 IC50 = 8.3 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
325 4 0 4 2.4 CC1=CC=CC=C1N2CCN(CC2)CCC3=NN=C4N3CCCC4
CHEMBL1201216 ada1d_human Human Yes 8.1 IC50 = 8.3 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
325 4 0 4 2.4 CC1=CC=CC=C1N2CCN(CC2)CCC3=NN=C4N3CCCC4
CHEMBL3740042 ada1d_human Human No 4.1 IC50 = 80550 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
440 6 0 4 4.6 CC1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3740042 ada1d_human Human No 4.1 IC50 = 80550 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
440 6 0 4 4.6 CC1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL216443 ada1d_rat Rat No 7.1 IC50 = 81.3 Funct
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
1162 33 6 20 6.2 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC(=CC=C4)CNCCCCCCNCCSSCCNCCCCCCNCC5=CC=CC(=C5)C(=O)N6CCN(CC6)C7=NC8=CC(=C(C=C8C(=N7)N)OC)OC)N)OC
CHEMBL1108 ada1d_human Human Yes 7.1 IC50 = 83 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
379 6 1 4 3.5 C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
CHEMBL54 ada1d_human Human Yes 7.1 IC50 = 84 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
376 6 1 4 3.2 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
CHEMBL54 ada1d_human Human Yes 7.1 IC50 = 84 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
376 6 1 4 3.2 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
CHEMBL3740558 ada1d_human Human No 6.1 IC50 = 866.4 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
468 7 0 5 4.0 CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3740558 ada1d_human Human No 6.1 IC50 = 866.4 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
468 7 0 5 4.0 CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL325745 ada1d_human Human No 6.1 IC50 = 871.0 Funct
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
258 6 3 3 2.3 CCCNC(=O)C1=CC=CC=C1NCC2=CN=CN2
CHEMBL3809032 ada1d_human Human No 6.1 IC50 = 883.2 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
456 13 3 6 3.3 CCC1=CC(=C(C=C1)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)OC
CHEMBL3809032 ada1d_human Human No 6.1 IC50 = 883.2 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
456 13 3 6 3.3 CCC1=CC(=C(C=C1)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)OC
CHEMBL808 ada1d_human Human Yes 5.1 IC50 = 8897 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
382 6 0 2 5.3 C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
CHEMBL95523 ada1d_human Human No 7.1 IC50 = 89.1 Funct
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
232 4 3 3 0.8 CNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL85 ada1d_human Human Yes 8.0 IC50 = 10.0 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL715 ada1d_human Human Yes 7.0 IC50 = 92 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
312 1 1 5 2.8 CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C
CHEMBL715 ada1d_human Human Yes 7.0 IC50 = 92 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
312 1 1 5 2.8 CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C
CHEMBL116700 ada1d_human Human No 6.0 IC50 = 933.3 Funct
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
250 4 1 2 3.2 C1=CC=C(C=C1)C2=CC=CC=C2OCC3=CN=CN3
CHEMBL3810145 ada1d_human Human No 7.0 IC50 = 94 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
528 13 3 8 4.1 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL3810145 ada1d_human Human No 7.0 IC50 = 94 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
528 13 3 8 4.1 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL199739 ada1d_rat Rat Yes 4.0 IC50 = 95500 Funct
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
286 1 4 6 2.1 C1=C(C=C(C=C1O)O)C2=CC3=CC(=CC(=C3OC2=O)O)O
CHEMBL199739 ada1d_rat Rat Yes 4.0 IC50 = 95500 Funct
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
286 1 4 6 2.1 C1=C(C=C(C=C1O)O)C2=CC3=CC(=CC(=C3OC2=O)O)O
CHEMBL3740874 ada1d_human Human No 6.0 IC50 = 957.2 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
469 6 0 6 4.1 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=C(C=C(C=C5)C#N)F
CHEMBL3740874 ada1d_human Human No 6.0 IC50 = 957.2 Funct
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
469 6 0 6 4.1 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=C(C=C(C=C5)C#N)F
CHEMBL81 ada1d_human Human Yes 6.0 IC50 = 973 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
474 7 2 6 6.1 C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
CHEMBL81 ada1d_human Human Yes 6.0 IC50 = 973 Funct
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
474 7 2 6 6.1 C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
CHEMBL3809543 ada1d_human Human No 6.0 IC50 = 996.1 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
440 11 3 5 3.7 CC1=C(C(=C(C=C1)C)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)C
CHEMBL3809543 ada1d_human Human No 6.0 IC50 = 996.1 Funct
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
440 11 3 5 3.7 CC1=C(C(=C(C=C1)C)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)C
CHEMBL13856 ada1d_rat Rat Yes 10.7 Kd = 0.0 Funct
In vitro functional activity at Alpha-1D receptor in rat aortaIn vitro functional activity at Alpha-1D receptor in rat aorta
477 6 1 6 4.2 CC1=CC=CC(=C1)C2=CSC3=C2C(=O)N(C(=O)N3)CCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL268758 ada1d_rat Rat Yes 10.6 Kd = 0.0 Funct
In vitro functional activity at Alpha-1D adrenergic receptor in rat aortaIn vitro functional activity at Alpha-1D adrenergic receptor in rat aorta
463 6 1 6 3.9 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(NC3=O)SC=C4C5=CC=CC=C5
CHEMBL342062 ada1d_rat Rat No 10.1 Kd = 0.1 Funct
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL42472 ada1d_rat Rat No 9.6 Kd = 0.3 Funct
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
420 9 1 5 5.0 COC1=C(C(=CC=C1)OC)OCCNCC2CC(C3=CC=CC=C3O2)C4=CC=CC=C4
CHEMBL144238 ada1d_rat Rat No 9.4 Kd = 0.4 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
490 12 1 8 4.0 CN(CCCCCCN(C)C(=O)C1=CC=C(O1)CCl)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL1630938 ada1d_rat Rat No 9.3 Kd = 0.5 Funct
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 mins
423 11 2 7 3.2 CC(C)OC1=CC=CC=C1OCCNC(C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N
CHEMBL1630938 ada1d_rat Rat No 9.3 Kd = 0.5 Funct
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 mins
423 11 2 7 3.2 CC(C)OC1=CC=CC=C1OCCNC(C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N
CHEMBL423294 ada1d_rat Rat Yes 9.2 Kd = 0.6 Funct
Antagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aortaAntagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aorta
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL423294 ada1d_rat Rat Yes 9.2 Kd = 0.6 Funct
Antagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aortaAntagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aorta
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL27013 ada1d_rat Rat No 9.2 Kd = 0.6 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
442 11 1 8 3.7 CN(CCCCCCN(C)C(=O)C1=CC=CO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL27013 ada1d_rat Rat No 9.2 Kd = 0.6 Funct
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
442 11 1 8 3.7 CN(CCCCCCN(C)C(=O)C1=CC=CO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL40650 ada1d_rat Rat Yes 9.1 Kd = 0.8 Funct
In vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aortaIn vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aorta
449 4 1 6 3.2 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=C(C6=C(S5)C=CC=N6)NC4=O
CHEMBL40650 ada1d_rat Rat Yes 9.1 Kd = 0.8 Funct
In vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aortaIn vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aorta
449 4 1 6 3.2 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=C(C6=C(S5)C=CC=N6)NC4=O
CHEMBL175934 ada1d_rat Rat No 9.1 Kd = 0.9 Funct
Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)
422 4 1 9 1.9 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCSS4)N)OC
CHEMBL179743 ada1d_rat Rat No 9.1 Kd = 0.9 Funct
Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)
445 4 1 9 2.9 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C4=CC(=O)C5=CC=CC=C5C4=O)N)OC
CHEMBL178673 ada1d_rat Rat No 9.0 Kd = 0.9 Funct
Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)
436 5 1 9 1.8 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)CC4CCSS4)N)OC
CHEMBL1630940 ada1d_rat Rat No 9.0 Kd = 1.0 Funct
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 mins
462 11 2 10 3.5 CC(CC1=CC(=C(C=C1)OC)S(=O)(=O)N)NCCOC2=CC=CC=C2OCC(F)(F)F
CHEMBL1630940 ada1d_rat Rat No 9.0 Kd = 1.0 Funct
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 mins
462 11 2 10 3.5 CC(CC1=CC(=C(C=C1)OC)S(=O)(=O)N)NCCOC2=CC=CC=C2OCC(F)(F)F
CHEMBL707 ada1d_rat Rat Yes 9.0 Kd = 1.1 Funct
Antagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aortaAntagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aorta
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL707 ada1d_rat Rat Yes 9.0 Kd = 1.1 Funct
Antagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aortaAntagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aorta
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL611 ada1d_rat Rat Yes 8.8 Kd = 1.5 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL611 ada1d_rat Rat Yes 8.8 Kd = 1.5 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL611 ada1d_rat Rat Yes 8.8 Kd = 1.5 Funct
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL44403 ada1d_rat Rat No 8.7 Kd = 2.0 Funct
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
432 9 1 5 5.2 COC1=C(C(=CC=C1)OC)OCCNCC2CC(C3=CC=CC=C3C2=O)C4=CC=CC=C4
CHEMBL327232 ada1d_rat Rat No 8.0 Kd = 10 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
414 8 2 7 2.8 CN(C)C(=O)C1=CC(=CN=C1NCCCN2CCN(CC2)C3=CC=CC=C3OC)O
CHEMBL88856 ada1d_rat Rat No 8.0 Kd = 10 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
393 7 1 6 2.9 CN(C)C(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=CC=CC=C3C#N
CHEMBL91278 ada1d_rat Rat No 8.0 Kd = 10 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
438 10 1 6 3.9 CN(C)C(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=CC=CC=C3OCC4CC4
CHEMBL90874 ada1d_rat Rat No 8.0 Kd = 10 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
426 9 2 6 3.9 CC(C)(C)NC(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL88435 ada1d_rat Rat No 8.0 Kd = 10 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
382 7 1 5 3.5 CC1=CC=CC=C1N2CCN(CC2)CCCNC3=C(C=CC=N3)C(=O)N(C)C
CHEMBL88512 ada1d_rat Rat No 8.0 Kd = 10 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
369 8 2 6 2.6 COC1=CC=CC=C1N2CCN(CC2)CCCNC3=C(C=CC=N3)C(=O)N
CHEMBL92259 ada1d_rat Rat No 8.0 Kd = 10 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
430 9 1 5 5.8 COC1=CC=CC=C1N2CCN(CC2)CCCNC3=CC=CC=C3C(=O)C4=CC=CC=C4
CHEMBL91547 ada1d_rat Rat No 7.0 Kd = 100 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
457 8 2 7 3.4 CN(C)C(=O)C1=CN=C2C=CN[N+]2=C1NCCCN3CCN(CC3)C4=C(C=C(C=C4)F)OC
CHEMBL91036 ada1d_rat Rat No 7.0 Kd = 100 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
451 8 1 9 4.3 CN(C)C(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=CC=CC=C3OC(F)(F)F
CHEMBL91989 ada1d_rat Rat No 7.0 Kd = 100 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
516 9 1 9 5.3 CN(C)C(=O)C1=C(C2=CC=CC=C2N=C1)NCCCN3CCN(CC3)C4=CC=CC=C4OCC(F)(F)F
CHEMBL91480 ada1d_rat Rat No 6.0 Kd = 1000 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
428 9 1 7 3.1 CN(C)C(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=C(C=C(C=C3)OC)OC
CHEMBL142635 ada1d_rat Rat Yes 7.9 Kd = 11.8 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
392 7 1 5 4.1 COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
CHEMBL3415011 ada1d_rat Rat No 7.9 Kd = 11.8 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
393 7 2 4 3.3 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(C=C3)NC=C4
CHEMBL142635 ada1d_rat Rat Yes 7.9 Kd = 11.8 Funct
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
392 7 1 5 4.1 COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
CHEMBL142635 ada1d_rat Rat Yes 7.9 Kd = 11.8 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
392 7 1 5 4.1 COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
CHEMBL3415011 ada1d_rat Rat No 7.9 Kd = 11.8 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
393 7 2 4 3.3 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(C=C3)NC=C4
CHEMBL1258345 ada1d_rat Rat No 7.0 Kd = 112.2 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
501 8 2 6 3.3 COC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)NC(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)O
CHEMBL1258345 ada1d_rat Rat No 7.0 Kd = 112.2 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
501 8 2 6 3.3 COC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)NC(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)O
CHEMBL178923 ada1d_rat Rat No 7.9 Kd = 12.0 Funct
Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)
478 8 1 9 2.9 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)CCCCC4CCSS4)N)OC
CHEMBL88181 ada1d_rat Rat No 7.9 Kd = 12.6 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
414 8 0 5 3.9 CN(C)C(=O)C1=CC=CC=C1SCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL314880 ada1d_rat Rat No 7.9 Kd = 12.6 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
447 8 1 5 3.9 CC1=CC(=C(C=C1)N2CCN(CC2)CCCNC3=C(C=CC=N3)C(=O)N(C)C)N4C=CC=C4
CHEMBL90878 ada1d_rat Rat No 6.9 Kd = 125.9 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
550 9 1 9 5.9 CN(C)C(=O)C1=CN=C2C(=C1NCCCN3CCN(CC3)C4=CC=CC=C4OCC(F)(F)F)C=CC=C2Cl
CHEMBL88160 ada1d_rat Rat No 6.9 Kd = 125.9 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
534 9 1 10 4.3 CC1=NN(C2=NC=C(C(=C12)NCCCN3CCN(CC3)C4=CC=CC=C4OCC(F)(F)F)C(=O)N(C)C)C
CHEMBL144263 ada1d_rat Rat No 7.9 Kd = 13.8 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
509 13 1 8 4.0 CN(C)CC1=CC=C(C=C1)C(=O)N(C)CCCCCCN(C)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL444648 ada1d_rat Rat No 5.9 Kd = 1349.0 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
587 12 1 8 3.8 CCOC(=O)CN1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3OC)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL444648 ada1d_rat Rat No 5.9 Kd = 1349.0 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
587 12 1 8 3.8 CCOC(=O)CN1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3OC)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL1258457 ada1d_rat Rat No 6.9 Kd = 138.0 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
515 9 2 6 3.7 CCOC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)NC(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)O
CHEMBL1258457 ada1d_rat Rat No 6.9 Kd = 138.0 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
515 9 2 6 3.7 CCOC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)NC(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)O
CHEMBL2261604 ada1d_rat Rat No 6.9 Kd = 138.0 Funct
Antagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) spleenAntagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) spleen
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL144000 ada1d_rat Rat No 7.8 Kd = 14.5 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
608 20 2 9 5.0 CNCCCCCCN(C)CC1=CC=CC(=C1)C(=O)N(C)CCCCCCN(C)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL484102 ada1d_rat Rat No 6.9 Kd = 141.3 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
515 8 1 6 3.5 CN1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3OC)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL484102 ada1d_rat Rat No 6.9 Kd = 141.3 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
515 8 1 6 3.5 CN1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3OC)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL1258344 ada1d_rat Rat No 5.8 Kd = 1445.4 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
471 7 2 5 3.3 C1CN(CCN1CC(CN2C(=O)NC(=O)C2(C3=CC=CC=C3)C4=CC=CC=C4)O)C5=CC=CC=C5
CHEMBL1258344 ada1d_rat Rat No 5.8 Kd = 1445.4 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
471 7 2 5 3.3 C1CN(CCN1CC(CN2C(=O)NC(=O)C2(C3=CC=CC=C3)C4=CC=CC=C4)O)C5=CC=CC=C5
CHEMBL3415017 ada1d_rat Rat No 7.8 Kd = 15.1 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
471 7 2 4 4.3 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(N3)C=C(C=C4)Br
CHEMBL3415017 ada1d_rat Rat No 7.8 Kd = 15.1 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
471 7 2 4 4.3 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(N3)C=C(C=C4)Br
CHEMBL312935 ada1d_rat Rat No 7.8 Kd = 15.9 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
413 9 1 6 2.9 CCOC1=CC=CC=C1OCCNC2CCN(CC2)C3=C(C=CC=N3)C(=O)N(C)C
CHEMBL330060 ada1d_rat Rat No 7.8 Kd = 15.9 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
397 8 1 5 3.9 CN(C)C(=O)C1=CC=CC=C1NCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL330579 ada1d_rat Rat No 7.8 Kd = 15.9 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
466 9 1 9 4.3 CN(C)C(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=CC=CC=C3OCC(F)(F)F
CHEMBL90287 ada1d_rat Rat No 7.8 Kd = 15.9 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
367 7 1 5 3.2 CN(C)C(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=CC=CC=C3
CHEMBL315496 ada1d_rat Rat No 6.8 Kd = 158.5 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
509 9 2 8 3.1 CN(C)C(=O)C1=CN=C2C(=C1NCCCN3CCN(CC3)C4=C(C=C(C=C4)F)OC)C=CC=C2C(=O)N
CHEMBL329773 ada1d_rat Rat No 6.8 Kd = 158.5 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
491 8 2 7 4.0 CN(C)C(=O)C1=CN=C2C(=CN[N+]2=C1NCCCN3CCN(CC3)C4=C(C=C(C=C4)F)OC)Cl
CHEMBL42558 ada1d_rat Rat No 7.8 Kd = 16.6 Funct
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
408 12 1 5 5.0 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2CC3=CC=CC=C3
CHEMBL43905 ada1d_rat Rat No 7.8 Kd = 17.4 Funct
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
436 9 1 5 5.5 COC1=C(C(=CC=C1)OC)OCCNCC2CC(C3=CC=CC=C3S2)C4=CC=CC=C4
CHEMBL3415018 ada1d_rat Rat No 7.7 Kd = 19.5 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
427 7 2 4 4.2 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(N3)C=CC(=C4)Cl
CHEMBL358060 ada1d_rat Rat No 7.7 Kd = 19.5 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
500 12 1 7 4.6 CN(CCCCCCN(C)C(=O)C1=CC=C(C=C1)CCl)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL3415018 ada1d_rat Rat No 7.7 Kd = 19.5 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
427 7 2 4 4.2 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(N3)C=CC(=C4)Cl
CHEMBL327872 ada1d_rat Rat No 7.7 Kd = 20.0 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
423 8 1 7 2.9 CN(C)C(=O)C1=C(N=CC(=C1)C#N)NCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL329160 ada1d_rat Rat No 7.7 Kd = 20.0 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
398 8 1 6 3.1 CN(C)C(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL89030 ada1d_rat Rat No 7.7 Kd = 20.0 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
411 8 1 5 4.2 CC1=CC(=C(C=C1)C(=O)N(C)C)NCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL91876 ada1d_rat Rat No 7.7 Kd = 20.0 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
424 8 1 6 3.6 COC1=CC=CC=C1N2CCN(CC2)CCCNC3=C(C=CC=N3)C(=O)N4CCCC4
CHEMBL490865 ada1d_rat Rat No 6.7 Kd = 195.0 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
529 9 1 6 3.8 CCOC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)N(C(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)C)O
CHEMBL490865 ada1d_rat Rat No 6.7 Kd = 195.0 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
529 9 1 6 3.8 CCOC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)N(C(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)C)O
CHEMBL327231 ada1d_rat Rat No 6.7 Kd = 199.5 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
521 8 1 9 3.4 CC1=NN(C2=NC=C(C(=C12)NCCCN3CCN(CC3)C4=C(C=C(C=C4)F)C5=NC=CO5)C(=O)N(C)C)C
CHEMBL357669 ada1d_rat Rat No 8.7 Kd = 2.0 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
481 12 2 8 3.0 CN(CCCCCCN(C)C(=O)C1=CC(=CC=C1)CN)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL611 ada1d_rat Rat Yes 8.7 Kd = 2.2 Funct
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of phenylephrine-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of phenylephrine-induced contractile response
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL611 ada1d_rat Rat Yes 8.7 Kd = 2.2 Funct
In vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aortaIn vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aorta
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL611 ada1d_rat Rat Yes 8.7 Kd = 2.2 Funct
In vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aortaIn vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aorta
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL3415020 ada1d_rat Rat No 8.6 Kd = 2.8 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
483 9 1 4 5.2 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=CC=CC=C4N3CC5=CC=CC=C5
CHEMBL3415020 ada1d_rat Rat No 8.6 Kd = 2.8 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
483 9 1 4 5.2 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=CC=CC=C4N3CC5=CC=CC=C5
CHEMBL144677 ada1d_rat Rat No 8.6 Kd = 2.8 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
500 12 1 7 4.6 CN(CCCCCCN(C)C(=O)C1=CC=CC=C1CCl)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL29591 ada1d_rat Rat Yes 8.5 Kd = 2.9 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
478 11 1 10 2.9 CN(CCSSCCN(C)C(=O)C1=CC=CO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL29591 ada1d_rat Rat Yes 8.5 Kd = 2.9 Funct
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
478 11 1 10 2.9 CN(CCSSCCN(C)C(=O)C1=CC=CO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL1630942 ada1d_rat Rat No 7.7 Kd = 21.4 Funct
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 mins
406 7 2 7 2.6 CC1C(OC2=CC=CC=C2O1)CNC(C)CC3=CC(=C(C=C3)OC)S(=O)(=O)N
CHEMBL1630942 ada1d_rat Rat No 7.7 Kd = 21.4 Funct
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 mins
406 7 2 7 2.6 CC1C(OC2=CC=CC=C2O1)CNC(C)CC3=CC(=C(C=C3)OC)S(=O)(=O)N
CHEMBL242723 ada1d_rat Rat No 6.7 Kd = 213.8 Funct
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
480 5 1 9 3.3 CC(=O)C1=CC=C(O1)C(=O)N2CCN(C3C2CCCC3)C4=NC5=CC(=C(C=C5C(=N4)N)OC)OC
CHEMBL242723 ada1d_rat Rat No 6.7 Kd = 213.8 Funct
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
480 5 1 9 3.3 CC(=O)C1=CC=C(O1)C(=O)N2CCN(C3C2CCCC3)C4=NC5=CC(=C(C=C5C(=N4)N)OC)OC
CHEMBL1257883 ada1d_rat Rat No 6.6 Kd = 245.5 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
503 7 1 6 3.6 CN1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3F)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL1257883 ada1d_rat Rat No 6.6 Kd = 245.5 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
503 7 1 6 3.6 CN1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3F)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL327168 ada1d_rat Rat No 7.6 Kd = 25.1 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
435 8 1 7 3.2 CN(C)C(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=CC=CC=C3C4=NC=CO4
CHEMBL89916 ada1d_rat Rat No 6.6 Kd = 251.2 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
454 10 1 6 4.4 CC(C)N(C(C)C)C(=O)C1=C(C=CN=C1)NCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL88109 ada1d_rat Rat No 5.6 Kd = 2511.9 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
447 8 1 7 2.5 CN(C)C(=O)C1=C(N=CC=C1)N2CCC(CC2)NCCOC3=CC=CC=C3C4=CN=CN=C4
CHEMBL3415015 ada1d_rat Rat No 7.6 Kd = 26.9 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
409 7 3 5 3.3 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(N3)C=CC(=C4)O
CHEMBL3415015 ada1d_rat Rat No 7.6 Kd = 26.9 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
409 7 3 5 3.3 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(N3)C=CC(=C4)O
CHEMBL423294 ada1d_rat Rat Yes 7.6 Kd = 26.9 Funct
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL448198 ada1d_rat Rat No 6.6 Kd = 269.2 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
601 12 1 8 4.2 CCOC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)N(C(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)C(C)C(=O)OC)O
CHEMBL448198 ada1d_rat Rat No 6.6 Kd = 269.2 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
601 12 1 8 4.2 CCOC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)N(C(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)C(C)C(=O)OC)O
CHEMBL321644 ada1d_rat Rat No 4.6 Kd = 27542.3 Funct
Antagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contractionAntagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contraction
359 4 2 7 2.8 C1CC(C2=C(C1)C(=CC=C2)NS(=O)(=O)CC(F)(F)F)C3=CN=CN3
CHEMBL3415016 ada1d_rat Rat No 7.6 Kd = 28.2 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
438 7 2 6 3.4 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(N3)C(=CC=C4)[N+](=O)[O-]
CHEMBL3415016 ada1d_rat Rat No 7.6 Kd = 28.2 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
438 7 2 6 3.4 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)C3=CC4=C(N3)C(=CC=C4)[N+](=O)[O-]
CHEMBL503007 ada1d_rat Rat No 6.5 Kd = 295.1 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
573 11 1 8 3.4 COC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)N(C(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)CC(=O)OC)O
CHEMBL503007 ada1d_rat Rat No 6.5 Kd = 295.1 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
573 11 1 8 3.4 COC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)N(C(=O)C3(C4=CC=CC=C4)C5=CC=CC=C5)CC(=O)OC)O
CHEMBL13647 ada1d_rat Rat Yes 8.5 Kd = 3.0 Funct
Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hrAntagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hr
386 5 0 5 2.8 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O
CHEMBL13647 ada1d_rat Rat Yes 8.5 Kd = 3.0 Funct
Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hrAntagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hr
386 5 0 5 2.8 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O
CHEMBL2419765 ada1d_rat Rat No 8.5 Kd = 3.0 Funct
Antagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysisAntagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysis
354 7 2 5 3.0 COC1=C(C2=C(C=C1)C=CN2)OCCNCC3COC4=CC=CC=C4O3
CHEMBL148061 ada1d_rat Rat No 8.5 Kd = 3.1 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
553 13 1 9 4.5 CN(CCCCCCN(C)C(=O)C1=CC(=CC=C1)CN2CCSC2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL144776 ada1d_rat Rat No 8.5 Kd = 3.2 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
580 19 3 9 4.0 CN(CCCCCCN(C)C(=O)C1=CC=CC=C1CNCCCCCCN)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL93054 ada1d_rat Rat No 8.5 Kd = 3.2 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
383 8 2 6 3.0 CNC(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL138681 ada1d_rat Rat No 8.5 Kd = 3.5 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
608 20 2 9 5.0 CNCCCCCCN(C)CC1=CC=C(C=C1)C(=O)N(C)CCCCCCN(C)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL313775 ada1d_rat Rat No 8.4 Kd = 4.0 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
520 9 2 10 4.1 CC1=NN(C2=NC=C(C(=C12)NCCCN3CCN(CC3)C4=CC=CC=C4OCC(F)(F)F)C(=O)NC)C
CHEMBL13647 ada1d_rat Rat Yes 8.4 Kd = 4.0 Funct
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
386 5 0 5 2.8 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O
CHEMBL329601 ada1d_rat Rat No 7.5 Kd = 31.6 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
414 8 1 6 3.7 CN(C)C(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=CC=CC=C3SC
CHEMBL90778 ada1d_rat Rat No 7.5 Kd = 31.6 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
398 8 1 6 2.6 CN(C)C(=O)C1=CN=C(C=C1)NCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL91400 ada1d_rat Rat No 7.5 Kd = 31.6 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
410 9 1 5 4.5 CCCC1=CC=CC=C1N2CCN(CC2)CCCNC3=C(C=CC=N3)C(=O)N(C)C
CHEMBL91338 ada1d_rat Rat No 7.5 Kd = 31.6 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
398 8 0 5 3.3 CN(C)C(=O)C1=CC=CC=C1OCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL314114 ada1d_rat Rat No 6.5 Kd = 316.2 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
435 7 1 8 4.1 CN(C)C(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=CC=CC=C3C(F)(F)F
CHEMBL419867 ada1d_rat Rat No 6.5 Kd = 316.2 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
480 8 1 7 4.6 CC1=CC=CC2=C(C(=CN=C12)C(=O)N(C)C)NCCCN3CCN(CC3)C4=C(C=C(C=C4)F)OC
CHEMBL91605 ada1d_rat Rat No 6.5 Kd = 316.2 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
484 8 1 8 3.3 CC1=NN(C2=NC=C(C(=C12)NCCCN3CCN(CC3)C4=C(C=C(C=C4)F)OC)C(=O)N(C)C)C
CHEMBL297106 ada1d_rat Rat No 7.5 Kd = 32.4 Funct
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
421 9 1 6 4.4 COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4
CHEMBL3415013 ada1d_rat Rat No 7.5 Kd = 34.7 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
421 9 2 4 3.5 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)CCC3=CNC4=CC=CC=C43
CHEMBL3415013 ada1d_rat Rat No 7.5 Kd = 34.7 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
421 9 2 4 3.5 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)CCC3=CNC4=CC=CC=C43
CHEMBL500266 ada1d_rat Rat No 6.5 Kd = 346.7 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
587 11 1 8 3.8 CC(C(=O)OC)N1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3OC)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL500266 ada1d_rat Rat No 6.5 Kd = 346.7 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
587 11 1 8 3.8 CC(C(=O)OC)N1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3OC)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL242724 ada1d_rat Rat No 7.5 Kd = 35.5 Funct
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
454 4 1 8 3.9 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CS5)N)OC
CHEMBL242724 ada1d_rat Rat No 7.5 Kd = 35.5 Funct
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
454 4 1 8 3.9 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CS5)N)OC
CHEMBL92901 ada1d_rat Rat No 7.4 Kd = 39.8 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
398 8 2 6 3.3 CC1=CC(=NC(=C1C(=O)N)NCCCN2CCN(CC2)C3=CC=CC=C3OC)C
CHEMBL91785 ada1d_rat Rat No 7.4 Kd = 39.8 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
412 8 1 6 3.5 CC1=CC(=C(C=C1)N2CCN(CC2)CCCNC3=C(C=CC=N3)C(=O)N(C)C)OC
CHEMBL89397 ada1d_rat Rat No 6.4 Kd = 398.1 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
491 8 1 8 4.0 CN(C)C(=O)C1=C(C2=CC=CC(=C2N=C1)C#N)NCCCN3CCN(CC3)C4=C(C=C(C=C4)F)OC
CHEMBL13647 ada1d_rat Rat Yes 8.3 Kd = 4.6 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
386 5 0 5 2.8 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O
CHEMBL564481 ada1d_rat Rat No 7.4 Kd = 40.7 Funct
Antagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aortaAntagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aorta
506 4 1 9 3.7 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5COC6=CC=CC=C6O5)N)OC
CHEMBL564481 ada1d_rat Rat No 7.4 Kd = 40.7 Funct
Antagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aortaAntagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aorta
506 4 1 9 3.7 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5COC6=CC=CC=C6O5)N)OC
CHEMBL1258228 ada1d_rat Rat No 5.4 Kd = 4365.2 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
543 10 1 7 3.4 COC(=O)CN1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL1258228 ada1d_rat Rat No 5.4 Kd = 4365.2 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
543 10 1 7 3.4 COC(=O)CN1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL29907 ada1d_rat Rat No 7.3 Kd = 45.7 Funct
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
450 11 3 10 2.6 COC1=C(C=C2C(=C1)C(=NC(=N2)NCCSSCCNC(=O)C3=CC=CO3)N)OC
CHEMBL3415014 ada1d_rat Rat No 8.3 Kd = 5.1 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
435 10 2 4 3.9 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)CCCC3=CNC4=CC=CC=C43
CHEMBL3415014 ada1d_rat Rat No 8.3 Kd = 5.1 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
435 10 2 4 3.9 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)CCCC3=CNC4=CC=CC=C43
CHEMBL3415012 ada1d_rat Rat No 8.3 Kd = 5.2 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
407 8 2 4 3.2 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)CC3=CNC4=CC=CC=C43
CHEMBL3415012 ada1d_rat Rat No 8.3 Kd = 5.2 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
407 8 2 4 3.2 COC1=CC=CC=C1N2CCN(CC2)CCCNC(=O)CC3=CNC4=CC=CC=C43
CHEMBL341665 ada1d_rat Rat No 8.3 Kd = 5.5 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
509 13 1 8 4.0 CN(C)CC1=CC=CC(=C1)C(=O)N(C)CCCCCCN(C)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL146724 ada1d_rat Rat No 8.3 Kd = 5.5 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
509 13 1 8 4.0 CN(C)CC1=CC=CC=C1C(=O)N(C)CCCCCCN(C)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL3415019 ada1d_rat Rat No 8.3 Kd = 5.5 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
407 7 1 4 3.2 CN1C=C(C2=CC=CC=C21)C(=O)NCCCN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL3415019 ada1d_rat Rat No 8.3 Kd = 5.5 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
407 7 1 4 3.2 CN1C=C(C2=CC=CC=C21)C(=O)NCCCN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL342997 ada1d_rat Rat No 8.2 Kd = 5.9 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
499 13 1 9 3.4 CN(C)CC1=CC=C(O1)C(=O)N(C)CCCCCCN(C)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL91093 ada1d_rat Rat No 7.3 Kd = 50.1 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
454 10 1 6 4.9 CC(C)(C)COC1=CC=CC=C1N2CCN(CC2)CCCNC3=C(C=CC=N3)C(=O)N(C)C
CHEMBL88633 ada1d_rat Rat No 7.3 Kd = 50.1 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
399 8 1 7 2.5 CN(C)C(=O)C1=NC=NC=C1NCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL93736 ada1d_rat Rat No 7.3 Kd = 50.1 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
398 8 1 6 2.8 CN(C)C(=O)C1=C(C=CN=C1)NCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL145384 ada1d_rat Rat No 7.3 Kd = 51.3 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
500 12 1 7 4.6 CN(CCCCCCN(C)C(=O)C1=CC(=CC=C1)CCl)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL423294 ada1d_rat Rat Yes 7.3 Kd = 53.7 Funct
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL423294 ada1d_rat Rat Yes 7.3 Kd = 53.7 Funct
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL423294 ada1d_rat Rat Yes 7.3 Kd = 53.7 Funct
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL2261604 ada1d_rat Rat No 7.3 Kd = 53.7 Funct
Competitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contractionCompetitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contraction
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL388884 ada1d_rat Rat No 7.2 Kd = 58.9 Funct
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
516 4 1 8 4.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=C(O5)Br)N)OC
CHEMBL3414578 ada1d_rat Rat No 7.2 Kd = 58.9 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
423 8 2 5 3.6 COC1=CC2=C(C=C1)NC(=C2)C(=O)NCCCN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL388884 ada1d_rat Rat No 7.2 Kd = 58.9 Funct
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
516 4 1 8 4.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=C(O5)Br)N)OC
CHEMBL3414578 ada1d_rat Rat No 7.2 Kd = 58.9 Funct
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
423 8 2 5 3.6 COC1=CC2=C(C=C1)NC(=C2)C(=O)NCCCN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL111734 ada1d_rat Rat Yes 5.2 Kd = 5888.4 Funct
Antagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contractionAntagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contraction
279 5 2 4 1.7 CCS(=O)(=O)NC1=CC=CC(=C1C)CC2=CN=CN2
CHEMBL146601 ada1d_rat Rat No 8.2 Kd = 6.0 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
535 13 1 11 2.7 CN(C)CC1=CC=C(O1)C(=O)N(C)CCSSCCN(C)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL13647 ada1d_rat Rat Yes 8.2 Kd = 6.0 Funct
In vitro functional activity at Alpha-1D adrenergic receptor in rat aortaIn vitro functional activity at Alpha-1D adrenergic receptor in rat aorta
386 5 0 5 2.8 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O
CHEMBL92261 ada1d_rat Rat No 8.2 Kd = 6.3 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
411 9 1 6 4.8 CC(C)(C)C(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL144768 ada1d_rat Rat No 8.2 Kd = 6.8 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
553 13 1 9 4.5 CN(CCCCCCN(C)C(=O)C1=CC=C(C=C1)CN2CCSC2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL144224 ada1d_rat Rat No 8.2 Kd = 6.9 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
452 11 1 7 4.2 CN(CCCCCCN(C)C(=O)C1=CC=CC=C1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL1630941 ada1d_rat Rat No 7.2 Kd = 60.3 Funct
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 mins
406 7 2 7 2.6 CC1C(OC2=CC=CC=C2O1)CNC(C)CC3=CC(=C(C=C3)OC)S(=O)(=O)N
CHEMBL1630941 ada1d_rat Rat No 7.2 Kd = 60.3 Funct
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 mins
406 7 2 7 2.6 CC1C(OC2=CC=CC=C2O1)CNC(C)CC3=CC(=C(C=C3)OC)S(=O)(=O)N
CHEMBL40325 ada1d_rat Rat No 7.2 Kd = 61.7 Funct
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
436 9 1 5 5.5 COC1=C(C(=CC=C1)OC)OCCNCC2CC(C3=CC=CC=C3S2)C4=CC=CC=C4
CHEMBL420620 ada1d_rat Rat No 7.2 Kd = 63.1 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
416 8 1 7 3.2 CN(C)C(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=C(C=C(C=C3)F)OC
CHEMBL90869 ada1d_rat Rat No 7.2 Kd = 63.1 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
467 9 1 9 3.6 CN(C)C(=O)C1=C(N=CC=C1)N2CCC(CC2)NCCOC3=CC=CC=C3OCC(F)(F)F
CHEMBL88664 ada1d_rat Rat No 7.2 Kd = 63.1 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
383 7 2 6 2.8 CN(C)C(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=CC=CC=C3O
CHEMBL88211 ada1d_rat Rat No 7.2 Kd = 63.1 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
410 8 1 5 4.3 CC(C)C1=CC=CC=C1N2CCN(CC2)CCCNC3=C(C=CC=N3)C(=O)N(C)C
CHEMBL90746 ada1d_rat Rat No 7.2 Kd = 63.1 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
444 8 1 5 4.8 CN(C)C(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL88820 ada1d_rat Rat No 7.2 Kd = 63.1 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
411 7 1 5 2.6 CN(C)C(=O)C1=CC=CC=C1NC(=O)CCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL91326 ada1d_rat Rat No 7.2 Kd = 63.1 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
411 8 1 5 4.2 CC1=CC=CC(=C1NCCCN2CCN(CC2)C3=CC=CC=C3OC)C(=O)N(C)C
CHEMBL89822 ada1d_rat Rat No 7.2 Kd = 63.1 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
576 10 1 10 5.6 CC(C)(C)C1=NN(C2=NC=C(C(=C12)NCCCN3CCN(CC3)C4=CC=CC=C4OCC(F)(F)F)C(=O)N(C)C)C
CHEMBL91951 ada1d_rat Rat No 7.2 Kd = 63.1 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
408 8 1 5 4.1 CN(C)C(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=CC=CC=C3C4CC4
CHEMBL326702 ada1d_rat Rat No 6.2 Kd = 631.0 Funct
Antagonistic activity against Alpha-1D adrenergic receptor determined using phenylephrine challenge in rat aorta isolated tissues.Antagonistic activity against Alpha-1D adrenergic receptor determined using phenylephrine challenge in rat aorta isolated tissues.
265 5 2 4 1.4 CCS(=O)(=O)NC1=CC=CC(=C1)CC2=CN=CN2
CHEMBL90810 ada1d_rat Rat No 6.2 Kd = 631.0 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
481 8 1 8 3.9 CC1=NC2=NC=C(C(=C2C=C1)NCCCN3CCN(CC3)C4=C(C=C(C=C4)F)OC)C(=O)N(C)C
CHEMBL326702 ada1d_rat Rat No 6.2 Kd = 660.7 Funct
Antagonist activity at rat aorta adrenergic Alpha-1D receptorAntagonist activity at rat aorta adrenergic Alpha-1D receptor
265 5 2 4 1.4 CCS(=O)(=O)NC1=CC=CC(=C1)CC2=CN=CN2
CHEMBL326702 ada1d_rat Rat No 6.2 Kd = 660.7 Funct
Antagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contractionAntagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contraction
265 5 2 4 1.4 CCS(=O)(=O)NC1=CC=CC(=C1)CC2=CN=CN2
CHEMBL326702 ada1d_rat Rat No 6.2 Kd = 660.7 Funct
Antagonist activity at rat aorta adrenergic Alpha-1D receptorAntagonist activity at rat aorta adrenergic Alpha-1D receptor
265 5 2 4 1.4 CCS(=O)(=O)NC1=CC=CC(=C1)CC2=CN=CN2
CHEMBL313157 ada1d_rat Rat No 8.1 Kd = 7.9 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
412 9 1 6 3.5 CCOC1=CC=CC=C1N2CCN(CC2)CCCNC3=C(C=CC=N3)C(=O)N(C)C
CHEMBL1256344 ada1d_rat Rat No 7.2 Kd = 70.8 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
601 12 1 8 4.2 CCOC(=O)C(C)N1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3OC)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL1256344 ada1d_rat Rat No 7.2 Kd = 70.8 Funct
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
601 12 1 8 4.2 CCOC(=O)C(C)N1C(=O)C(N(C1=O)CC(CN2CCN(CC2)C3=CC=CC=C3OC)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL2261355 ada1d_rat Rat No 5.1 Kd = 7244.4 Funct
Antagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contractionAntagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contraction
305 4 2 4 2.1 CCS(=O)(=O)NC1=CC=CC2=C1CCCC2C3=CN=CN3
CHEMBL11553 ada1d_rat Rat Yes 5.1 Kd = 7762.5 Funct
Compound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of ratCompound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of rat
333 8 1 2 4.5 CN(C)CCC1=CN=C(N1)CCC(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL315785 ada1d_rat Rat No 7.1 Kd = 79.4 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
484 8 1 8 3.2 CC1=NC2=C(C(=CN=C2N1C)C(=O)N(C)C)NCCCN3CCN(CC3)C4=C(C=C(C=C4)F)OC
CHEMBL327351 ada1d_rat Rat No 7.1 Kd = 79.4 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
414 8 2 7 2.8 CN(C)C(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=C(C=C(C=C3)O)OC
CHEMBL328545 ada1d_rat Rat No 7.1 Kd = 79.4 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
458 9 1 5 5.1 CN(C)C(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=CC=CC=C3CC4=CC=CC=C4
CHEMBL90022 ada1d_rat Rat No 7.1 Kd = 79.4 Funct
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
521 9 1 11 4.4 CC1=NOC2=NC=C(C(=C12)NCCCN3CCN(CC3)C4=CC=CC=C4OCC(F)(F)F)C(=O)N(C)C
CHEMBL242508 ada1d_rat Rat No 7.1 Kd = 89.1 Funct
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
468 5 1 9 3.6 COC1=CC=C(O1)C(=O)N2CCN(C3C2CCCC3)C4=NC5=CC(=C(C=C5C(=N4)N)OC)OC
CHEMBL242508 ada1d_rat Rat No 7.1 Kd = 89.1 Funct
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
468 5 1 9 3.6 COC1=CC=C(O1)C(=O)N2CCN(C3C2CCCC3)C4=NC5=CC(=C(C=C5C(=N4)N)OC)OC
CHEMBL145181 ada1d_rat Rat No 8.0 Kd = 9.3 Funct
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
526 12 1 10 3.3 CN(CCSSCCN(C)C(=O)C1=CC=C(O1)CCl)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL242507 ada1d_rat Rat No 7.0 Kd = 91.2 Funct
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
452 4 1 8 3.8 CC1=CC=C(O1)C(=O)N2CCN(C3C2CCCC3)C4=NC5=CC(=C(C=C5C(=N4)N)OC)OC
CHEMBL242507 ada1d_rat Rat No 7.0 Kd = 91.2 Funct
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
452 4 1 8 3.8 CC1=CC=C(O1)C(=O)N2CCN(C3C2CCCC3)C4=NC5=CC(=C(C=C5C(=N4)N)OC)OC
CHEMBL42231 ada1d_rat Rat No 7.0 Kd = 91.2 Funct
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
418 9 1 4 5.5 COC1=C(C(=CC=C1)OC)OCCNCC2CC(C3=CC=CC=C3C2)C4=CC=CC=C4
CHEMBL324090 ada1d_rat Rat Yes 10.5 Ki = 0.0 Funct
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
395 5 1 7 3.4 COC1=C(C=C2CN(CCC2=C1)C3=NC4=CC(=C(C=C4C(=C3)N)OC)OC)OC
CHEMBL200446 ada1d_human Human No 10.5 Ki = 0.0 Funct
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
458 13 1 6 5.2 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC=C(C=C3)Cl
CHEMBL200446 ada1d_human Human No 10.5 Ki = 0.0 Funct
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
458 13 1 6 5.2 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC=C(C=C3)Cl
CHEMBL324090 ada1d_human Human Yes 10.4 Ki = 0.0 Funct
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
395 5 1 7 3.4 COC1=C(C=C2CN(CCC2=C1)C3=NC4=CC(=C(C=C4C(=C3)N)OC)OC)OC
CHEMBL198860 ada1d_human Human No 10.3 Ki = 0.1 Funct
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
458 13 1 6 5.2 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC(=CC=C3)Cl
CHEMBL196817 ada1d_human Human No 10.3 Ki = 0.1 Funct
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
469 13 1 8 4.4 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC=C(C=C3)[N+](=O)[O-]
CHEMBL198860 ada1d_human Human No 10.3 Ki = 0.1 Funct
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
458 13 1 6 5.2 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC(=CC=C3)Cl
CHEMBL196817 ada1d_human Human No 10.3 Ki = 0.1 Funct
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
469 13 1 8 4.4 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC=C(C=C3)[N+](=O)[O-]
CHEMBL3297829 ada1d_human Human No 10.3 Ki = 0.1 Funct
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
669 12 2 8 4.0 CN(CC1=CC=CC=C1)C(=O)CCCC(=O)NC2=CC3=C(C=C2)SC4=C3NC(=O)N(C4=O)CCN5CCN(CC5)C6=CC=CC=C6OC
CHEMBL3297829 ada1d_human Human No 10.3 Ki = 0.1 Funct
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
669 12 2 8 4.0 CN(CC1=CC=CC=C1)C(=O)CCCC(=O)NC2=CC3=C(C=C2)SC4=C3NC(=O)N(C4=O)CCN5CCN(CC5)C6=CC=CC=C6OC
CHEMBL342062 ada1d_human Human No 10.2 Ki = 0.1 Funct
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL197442 ada1d_human Human No 10.2 Ki = 0.1 Funct
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
469 13 1 8 4.4 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL200366 ada1d_human Human No 10.2 Ki = 0.1 Funct
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
438 13 1 6 4.9 CC1=CC=C(C=C1)COC2=CC=CC=C2OCCNCCOC3=C(C=CC=C3OC)OC
CHEMBL197442 ada1d_human Human No 10.2 Ki = 0.1 Funct
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
469 13 1 8 4.4 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC(=CC=C3)[N+](=O)[O-]
CHEMBL200366 ada1d_human Human No 10.2 Ki = 0.1 Funct
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
438 13 1 6 4.9 CC1=CC=C(C=C1)COC2=CC=CC=C2OCCNCCOC3=C(C=CC=C3OC)OC
CHEMBL43116 ada1d_human Human No 10.2 Ki = 0.1 Funct
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
424 13 1 6 4.5 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC=CC=C3
CHEMBL43116 ada1d_human Human No 10.2 Ki = 0.1 Funct
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
424 13 1 6 4.5 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC=CC=C3
CHEMBL43116 ada1d_human Human No 10.2 Ki = 0.1 Funct
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
424 13 1 6 4.5 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC=CC=C3
CHEMBL43116 ada1d_human Human No 10.2 Ki = 0.1 Funct
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
424 13 1 6 4.5 COC1=C(C(=CC=C1)OC)OCCNCCOC2=CC=CC=C2OCC3=CC=CC=C3
CHEMBL303313 ada1d_rat Rat Yes 10.1 Ki = 0.1 Funct
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
345 1 0 3 4.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL303313 ada1d_rat Rat Yes 10.1 Ki = 0.1 Funct
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
345 1 0 3 4.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL1259112 ada1d_rat Rat Yes 10.1 Ki = 0.1 Funct
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
335 1 0 4 3.4 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C#N
CHEMBL1259112 ada1d_rat Rat Yes 10.1 Ki = 0.1 Funct
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
335 1 0 4 3.4 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C#N
CHEMBL42472 ada1d_human Human No 10.1 Ki = 0.1 Funct
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
420 9 1 5 5.0 COC1=C(C(=CC=C1)OC)OCCNCC2CC(C3=CC=CC=C3O2)C4=CC=CC=C4
CHEMBL243694 ada1d_human Human No 10.1 Ki = 0.1 Funct
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
466 5 0 6 4.7 CC(C)OC1=CC=CC=C1N2CCN(CC2)C3CCC(CC3)N4C(=O)C5=C(C4=O)C(=CC=C5)F
CHEMBL243694 ada1d_human Human No 10.1 Ki = 0.1 Funct
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
466 5 0 6 4.7 CC(C)OC1=CC=CC=C1N2CCN(CC2)C3CCC(CC3)N4C(=O)C5=C(C4=O)C(=CC=C5)F
CHEMBL200580 ada1d_human Human No 10.0 Ki = 0.1 Funct
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
454 14 1 7 4.5 COC1=CC=C(C=C1)COC2=CC=CC=C2OCCNCCOC3=C(C=CC=C3OC)OC
CHEMBL200580 ada1d_human Human No 10.0 Ki = 0.1 Funct
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
454 14 1 7 4.5 COC1=CC=C(C=C1)COC2=CC=CC=C2OCCNCCOC3=C(C=CC=C3OC)OC
CHEMBL301224 ada1d_rat Rat No 10.0 Ki = 0.1 Funct
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
410 4 0 3 4.7 C1CCC2(C1)CCN(C(=O)C2)CCN3CCN(CC3)C4=C(C=CC(=C4)Cl)Cl
CHEMBL382972 ada1d_human Human No 9.9 Ki = 0.1 Funct
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
438 13 1 6 4.9 CC1=CC=CC=C1COC2=CC=CC=C2OCCNCCOC3=C(C=CC=C3OC)OC
CHEMBL382972 ada1d_human Human No 9.9 Ki = 0.1 Funct
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
438 13 1 6 4.9 CC1=CC=CC=C1COC2=CC=CC=C2OCCNCCOC3=C(C=CC=C3OC)OC
CHEMBL56438 ada1d_human Human No 9.9 Ki = 0.1 Funct
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
424 4 0 4 4.1 C1CCC2(C1)CC(=O)N(C(=O)C2)CCN3CCN(CC3)C4=C(C=CC(=C4)Cl)Cl
CHEMBL56438 ada1d_human Human No 9.9 Ki = 0.1 Funct
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
424 4 0 4 4.1 C1CCC2(C1)CC(=O)N(C(=O)C2)CCN3CCN(CC3)C4=C(C=CC(=C4)Cl)Cl
CHEMBL56438 ada1d_rat Rat No 9.9 Ki = 0.1 Funct
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
424 4 0 4 4.1 C1CCC2(C1)CC(=O)N(C(=O)C2)CCN3CCN(CC3)C4=C(C=CC(=C4)Cl)Cl
CHEMBL80641 ada1d_human Human No 9.9 Ki = 0.1 Funct
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
462 8 1 7 3.7 CC(=O)C1=C(C(=O)N(N=C1C2=CC=CC=C2)C)NCCN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL232609 ada1d_human Human No 9.9 Ki = 0.1 Funct
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
572 7 1 7 5.2 CC(C)OC1=CC=CC=C1N2CCN(CC2)C3CCC(CC3)NS(=O)(=O)C4=CC(=C(N=C4)Cl)Br
CHEMBL233790 ada1d_human Human No 9.9 Ki = 0.1 Funct
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
572 7 1 7 5.2 CC(C)OC1=CC=CC=C1N2CCN(CC2)C3CCC(CC3)NS(=O)(=O)C4=CC(=C(N=C4)Cl)Br
CHEMBL1259144 ada1d_rat Rat No 9.9 Ki = 0.1 Funct
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
382 3 1 4 2.8 CC(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL556313 ada1d_rat Rat No 9.9 Ki = 0.1 Funct
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
391 4 0 6 3.0 C1CCC2(C1)CC(=O)N(C(=O)C2)CCN3CCN(CC3)C4=C(C=CC(=C4)F)F
CHEMBL1259144 ada1d_rat Rat No 9.9 Ki = 0.1 Funct
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
382 3 1 4 2.8 CC(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL3298750 ada1d_human Human No 9.9 Ki = 0.1 Funct
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
655 12 3 8 3.8 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(C5=C(S4)C=CC(=C5)NC(=O)CCCC(=O)NCC6=CC=CC=C6)NC3=O
CHEMBL3298750 ada1d_human Human No 9.9 Ki = 0.1 Funct
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
655 12 3 8 3.8 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(C5=C(S4)C=CC(=C5)NC(=O)CCCC(=O)NCC6=CC=CC=C6)NC3=O
CHEMBL1259113 ada1d_rat Rat No 9.8 Ki = 0.2 Funct
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
340 2 1 4 2.6 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)CN
CHEMBL303313 ada1d_rat Rat Yes 9.8 Ki = 0.2 Funct
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
345 1 0 3 4.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL1259113 ada1d_rat Rat No 9.8 Ki = 0.2 Funct
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
340 2 1 4 2.6 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)CN
CHEMBL220515 ada1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
452 5 1 5 3.6 CC1=NC2=C(C(=O)N1CCN3CCN(CC3)C4=C(C=CC(=C4)Cl)OC)NC5=CC=CC=C52
CHEMBL220515 ada1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
452 5 1 5 3.6 CC1=NC2=C(C(=O)N1CCN3CCN(CC3)C4=C(C=CC(=C4)Cl)OC)NC5=CC=CC=C52
CHEMBL423294 ada1d_human Human Yes 9.8 Ki = 0.2 Funct
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL564481 ada1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
506 4 1 9 3.7 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5COC6=CC=CC=C6O5)N)OC
CHEMBL1259145 ada1d_rat Rat No 9.8 Ki = 0.2 Funct
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
410 4 1 4 3.9 CC(C)C(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL13856 ada1d_rat Rat Yes 9.8 Ki = 0.2 Funct
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
477 6 1 6 4.2 CC1=CC=CC(=C1)C2=CSC3=C2C(=O)N(C(=O)N3)CCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL423294 ada1d_human Human Yes 9.8 Ki = 0.2 Funct
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
438 4 1 8 3.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC
CHEMBL564481 ada1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
506 4 1 9 3.7 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5COC6=CC=CC=C6O5)N)OC
CHEMBL1259145 ada1d_rat Rat No 9.8 Ki = 0.2 Funct
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
410 4 1 4 3.9 CC(C)C(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL1254582 ada1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
440 13 1 6 5.1 COC1=C(C(=CC=C1)OC)SCCNCCOC2=CC=CC=C2OCC3=CC=CC=C3
CHEMBL1254582 ada1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
440 13 1 6 5.1 COC1=C(C(=CC=C1)OC)SCCNCCOC2=CC=CC=C2OCC3=CC=CC=C3
CHEMBL293539 ada1d_rat Rat No 9.8 Ki = 0.2 Funct
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
408 4 0 5 3.6 C1CCC2(C1)CC(=O)N(C(=O)C2)CCN3CCN(CC3)C4=C(C=CC(=C4)F)Cl
CHEMBL355784 ada1d_human Human No 9.8 Ki = 0.2 Funct
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
257 2 1 2 2.8 CC(C1=CN=CN1)C2=C(C=CS2)Br
CHEMBL44403 ada1d_human Human No 9.7 Ki = 0.2 Funct
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
432 9 1 5 5.2 COC1=C(C(=CC=C1)OC)OCCNCC2CC(C3=CC=CC=C3C2=O)C4=CC=CC=C4
CHEMBL27013 ada1d_human Human No 9.7 Ki = 0.2 Funct
Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
442 11 1 8 3.7 CN(CCCCCCN(C)C(=O)C1=CC=CO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL199080 ada1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
438 13 1 6 4.9 CC1=CC(=CC=C1)COC2=CC=CC=C2OCCNCCOC3=C(C=CC=C3OC)OC
CHEMBL243864 ada1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
498 5 0 5 5.9 CC(C)OC1=CC=CC=C1N2CCN(CC2)C3CCC(CC3)N4C(=O)C5=C(C4=O)C6=CC=CC=C6C=C5
CHEMBL57868 ada1d_rat Rat No 9.7 Ki = 0.2 Funct
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
415 4 0 5 3.2 C1CCC2(C1)CC(=O)N(C(=O)C2)CCN3CCN(CC3)C4=C(C=CC(=C4)Cl)C#N
CHEMBL243864 ada1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
498 5 0 5 5.9 CC(C)OC1=CC=CC=C1N2CCN(CC2)C3CCC(CC3)N4C(=O)C5=C(C4=O)C6=CC=CC=C6C=C5
CHEMBL199080 ada1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
438 13 1 6 4.9 CC1=CC(=CC=C1)COC2=CC=CC=C2OCCNCCOC3=C(C=CC=C3OC)OC
CHEMBL1259190 ada1d_rat Rat No 9.7 Ki = 0.2 Funct
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
410 4 1 4 3.9 CC(C)C(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL58956 ada1d_rat Rat No 9.7 Ki = 0.2 Funct
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
421 5 1 5 2.8 COC1=CC2=C(C=C1)C(=O)N(C(=O)N2)CCN3CC4CCC5=C(C4C3)C=CC=C5OC
CHEMBL1259190 ada1d_rat Rat No 9.7 Ki = 0.2 Funct
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
410 4 1 4 3.9 CC(C)C(=O)NCC1=CC2=C(C=C1)SC3=CC=CC=C3CC2N4CCN(CC4)C
CHEMBL268758 ada1d_rat Rat Yes 9.7 Ki = 0.2 Funct
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
463 6 1 6 3.9 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(NC3=O)SC=C4C5=CC=CC=C5
CHEMBL13735 ada1d_rat Rat No 9.6 Ki = 0.2 Funct
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
386 5 1 6 2.2 COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(NC3=O)SC=C4
CHEMBL64875 ada1d_rat Rat No 9.6 Ki = 0.2 Funct
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
345 1 0 3 4.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL64875 ada1d_rat Rat No 9.6 Ki = 0.2 Funct
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
345 1 0 3 4.3 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL1259042 ada1d_rat Rat No 9.6 Ki = 0.2 Funct
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
389 2 0 5 3.6 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=CN=CN=C5
CHEMBL62028 ada1d_rat Rat No 9.6 Ki = 0.2 Funct
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
428 5 1 6 3.1 COC1=CC=CC2=C1CCC3C2CN(C3)CCN4C(=O)C5=C(C=C(S5)OC)NC4=O
CHEMBL1259042 ada1d_rat Rat No 9.6 Ki = 0.2 Funct
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
389 2 0 5 3.6 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)C5=CN=CN=C5
CHEMBL1630938 ada1d_human<