Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 1481 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4 | 4.0 | -109647 | 6 | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 3749 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4 | 4.0 | -109647 | 6 | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 3749.0 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4 | 4.0 | -109647 | 6 | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 589 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4 | 4.0 | -109647 | 6 | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 6908 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4 | 4.0 | -109647 | 6 | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1513 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4 | 4.0 | -109647 | 6 | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| DB01029 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4 | 4.0 | -109647 | 6 | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 40466887 | 208333 | None | 47 | Human | Functional | pAC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 424 | 9 | 2 | 5 | 2.6 | CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O | 10.1038/s41467-023-40064-9 | |||
| 5362124 | 208333 | None | 47 | Human | Functional | pAC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 424 | 9 | 2 | 5 | 2.6 | CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL838 | 208333 | None | 47 | Human | Functional | pAC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 424 | 9 | 2 | 5 | 2.6 | CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O | 10.1038/s41467-023-40064-9 | |||
| 1610 | 2347 | None | 64 | Human | Functional | pAC50 | = | 6.3 | 6.3 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3941 | 2347 | None | 64 | Human | Functional | pAC50 | = | 6.3 | 6.3 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3961 | 2347 | None | 64 | Human | Functional | pAC50 | = | 6.3 | 6.3 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3961.0 | 2347 | None | 64 | Human | Functional | pAC50 | = | 6.3 | 6.3 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 590 | 2347 | None | 64 | Human | Functional | pAC50 | = | 6.3 | 6.3 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL191 | 2347 | None | 64 | Human | Functional | pAC50 | = | 6.3 | 6.3 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| DB00678 | 2347 | None | 64 | Human | Functional | pAC50 | = | 6.3 | 6.3 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 158781 | 44180 | None | 60 | Human | Functional | pAC50 | = | 4.3 | 4.3 | -95499 | 3 | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1516 | 44180 | None | 60 | Human | Functional | pAC50 | = | 4.3 | 4.3 | -95499 | 3 | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 1610 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.2 | 4.2 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3941 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.2 | 4.2 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3961 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.2 | 4.2 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3961.0 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.2 | 4.2 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 590 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.2 | 4.2 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL191 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.2 | 4.2 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| DB00678 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.2 | 4.2 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 1610 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3941 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3961 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3961.0 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 590 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL191 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| DB00678 | 2347 | None | 64 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 130881 | 2921 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -23442 | 3 | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 130881.0 | 2921 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -23442 | 3 | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 1985 | 2921 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -23442 | 3 | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 591 | 2921 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -23442 | 3 | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1200692 | 2921 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -23442 | 3 | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| DB00275 | 2921 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -23442 | 3 | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 40466887 | 208333 | None | 47 | Human | Functional | pAC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 424 | 9 | 2 | 5 | 2.6 | CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O | 10.1038/s41467-023-40064-9 | |||
| 5362124 | 208333 | None | 47 | Human | Functional | pAC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 424 | 9 | 2 | 5 | 2.6 | CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL838 | 208333 | None | 47 | Human | Functional | pAC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 424 | 9 | 2 | 5 | 2.6 | CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O | 10.1038/s41467-023-40064-9 | |||
| 2541 | 786 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -45708 | 10 | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 2541.0 | 786 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -45708 | 10 | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 587 | 786 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -45708 | 10 | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 6907 | 786 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -45708 | 10 | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1016 | 786 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -45708 | 10 | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| DB00796 | 786 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -45708 | 10 | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| DB13919 | 786 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -45708 | 10 | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 3033 | 30160 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -8709 | 4 | ChEMBL | 295 | 4 | 2 | 2 | 4.4 | O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1034 | 30160 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -8709 | 4 | ChEMBL | 295 | 4 | 2 | 2 | 4.4 | O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL139 | 30160 | None | 65 | Human | Functional | pAC50 | = | 4.1 | 4.1 | -8709 | 4 | ChEMBL | 295 | 4 | 2 | 2 | 4.4 | O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl | 10.1038/s41467-023-40064-9 | |||
| 2540 | 4402 | None | 68 | Human | Functional | pAC50 | = | 5.0 | 5.0 | -1380 | 28 | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1014 | 4402 | None | 68 | Human | Functional | pAC50 | = | 5.0 | 5.0 | -1380 | 28 | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 1481 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4.0 | 4.0 | -109647 | 6 | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 3749 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4.0 | 4.0 | -109647 | 6 | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 3749.0 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4.0 | 4.0 | -109647 | 6 | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 589 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4.0 | 4.0 | -109647 | 6 | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 6908 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4.0 | 4.0 | -109647 | 6 | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1513 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4.0 | 4.0 | -109647 | 6 | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| DB01029 | 2066 | None | 66 | Human | Functional | pAC50 | = | 4.0 | 4.0 | -109647 | 6 | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 44377942 | 57471 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 530 | 6 | 2 | 5 | 5.9 | O=S(=O)(Nc1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1)C(F)(F)F | 10.1021/jm1013693 | |||
| CHEMBL165572 | 57471 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 530 | 6 | 2 | 5 | 5.9 | O=S(=O)(Nc1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1)C(F)(F)F | 10.1021/jm1013693 | |||
| 44355628 | 24914 | None | 0 | Rat | Functional | pIC50 | = | 6 | 6.0 | -5 | 2 | ChEMBL | 508 | 6 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O | 10.1021/jm00078a013 | |||
| CHEMBL134567 | 24914 | None | 0 | Rat | Functional | pIC50 | = | 6 | 6.0 | -5 | 2 | ChEMBL | 508 | 6 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O | 10.1021/jm00078a013 | |||
| 10411653 | 24432 | None | 0 | Rat | Functional | pIC50 | = | 5 | 5.0 | -208 | 2 | ChEMBL | 454 | 5 | 1 | 5 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O | 10.1021/jm00078a013 | |||
| CHEMBL134151 | 24432 | None | 0 | Rat | Functional | pIC50 | = | 5 | 5.0 | -208 | 2 | ChEMBL | 454 | 5 | 1 | 5 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O | 10.1021/jm00078a013 | |||
| 10410730 | 24626 | None | 0 | Rat | Functional | pIC50 | = | 5.0 | 5.0 | -6 | 2 | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 | 10.1021/jm00078a013 | |||
| CHEMBL134307 | 24626 | None | 0 | Rat | Functional | pIC50 | = | 5.0 | 5.0 | -6 | 2 | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 | 10.1021/jm00078a013 | |||
| 10048220 | 26197 | None | 0 | Rat | Functional | pIC50 | = | 5.0 | 5.0 | -109 | 2 | ChEMBL | 428 | 7 | 2 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | |||
| CHEMBL135704 | 26197 | None | 0 | Rat | Functional | pIC50 | = | 5.0 | 5.0 | -109 | 2 | ChEMBL | 428 | 7 | 2 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | |||
| 10322995 | 115327 | None | 0 | Rat | Functional | pIC50 | = | 5.0 | 5.0 | -134 | 2 | ChEMBL | 482 | 9 | 1 | 5 | 6.1 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C | 10.1021/jm00078a014 | |||
| CHEMBL334832 | 115327 | None | 0 | Rat | Functional | pIC50 | = | 5.0 | 5.0 | -134 | 2 | ChEMBL | 482 | 9 | 1 | 5 | 6.1 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C | 10.1021/jm00078a014 | |||
| 10003482 | 165838 | None | 0 | Rat | Functional | pIC50 | = | 5.0 | 5.0 | -158 | 2 | ChEMBL | 442 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | |||
| CHEMBL424643 | 165838 | None | 0 | Rat | Functional | pIC50 | = | 5.0 | 5.0 | -158 | 2 | ChEMBL | 442 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | |||
| 10364891 | 26253 | None | 0 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | -33 | 2 | ChEMBL | 421 | 5 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 | 10.1021/jm00078a013 | |||
| CHEMBL135792 | 26253 | None | 0 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | -33 | 2 | ChEMBL | 421 | 5 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 | 10.1021/jm00078a013 | |||
| 192345 | 26244 | None | 3 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | -12022 | 2 | ChEMBL | 496 | 6 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | |||
| CHEMBL135775 | 26244 | None | 3 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | -12022 | 2 | ChEMBL | 496 | 6 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | |||
| 10393397 | 22807 | None | 0 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | -6 | 2 | ChEMBL | 578 | 8 | 1 | 5 | 7.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | |||
| CHEMBL132807 | 22807 | None | 0 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | -6 | 2 | ChEMBL | 578 | 8 | 1 | 5 | 7.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | |||
| 10367704 | 22350 | None | 0 | Rat | Functional | pIC50 | = | 6.9 | 6.9 | -25 | 2 | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | |||
| CHEMBL132408 | 22350 | None | 0 | Rat | Functional | pIC50 | = | 6.9 | 6.9 | -25 | 2 | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | |||
| 10094520 | 24766 | None | 0 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | -11 | 2 | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C | 10.1021/jm00078a013 | |||
| CHEMBL134433 | 24766 | None | 0 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | -11 | 2 | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C | 10.1021/jm00078a013 | |||
| 15698118 | 208601 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 537 | 10 | 2 | 6 | 5.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)NS(=O)(=O)c2ccccc2)cc1 | 10.1021/jm1013693 | |||
| CHEMBL86067 | 208601 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 537 | 10 | 2 | 6 | 5.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)NS(=O)(=O)c2ccccc2)cc1 | 10.1021/jm1013693 | |||
| 44355660 | 21564 | None | 0 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | -89 | 2 | ChEMBL | 483 | 7 | 1 | 7 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 | 10.1021/jm00078a013 | |||
| CHEMBL131676 | 21564 | None | 0 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | -89 | 2 | ChEMBL | 483 | 7 | 1 | 7 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 | 10.1021/jm00078a013 | |||
| 11743704 | 115562 | None | 0 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | -3 | 2 | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 | 10.1021/jm00078a013 | |||
| CHEMBL335179 | 115562 | None | 0 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | -3 | 2 | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 | 10.1021/jm00078a013 | |||
| 10026268 | 116994 | None | 0 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | -173 | 2 | ChEMBL | 440 | 6 | 1 | 5 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 | 10.1021/jm00078a013 | |||
| CHEMBL338505 | 116994 | None | 0 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | -173 | 2 | ChEMBL | 440 | 6 | 1 | 5 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 | 10.1021/jm00078a013 | |||
| 10322504 | 26391 | None | 0 | Rat | Functional | pIC50 | = | 5.8 | 5.8 | -19 | 2 | ChEMBL | 470 | 9 | 1 | 5 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | |||
| CHEMBL135929 | 26391 | None | 0 | Rat | Functional | pIC50 | = | 5.8 | 5.8 | -19 | 2 | ChEMBL | 470 | 9 | 1 | 5 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | |||
| 10095493 | 26056 | None | 0 | Rat | Functional | pIC50 | = | 4.8 | 4.8 | -93 | 2 | ChEMBL | 454 | 6 | 0 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 | 10.1021/jm00078a013 | |||
| CHEMBL135521 | 26056 | None | 0 | Rat | Functional | pIC50 | = | 4.8 | 4.8 | -93 | 2 | ChEMBL | 454 | 6 | 0 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 | 10.1021/jm00078a013 | |||
| 11754335 | 25311 | None | 0 | Rat | Functional | pIC50 | = | 4.8 | 4.8 | -186 | 2 | ChEMBL | 467 | 5 | 2 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 | 10.1021/jm00078a013 | |||
| CHEMBL134901 | 25311 | None | 0 | Rat | Functional | pIC50 | = | 4.8 | 4.8 | -186 | 2 | ChEMBL | 467 | 5 | 2 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 | 10.1021/jm00078a013 | |||
| 1610 | 2347 | None | 64 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm1013693 | |||
| 3941 | 2347 | None | 64 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm1013693 | |||
| 3961 | 2347 | None | 64 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm1013693 | |||
| 3961.0 | 2347 | None | 64 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm1013693 | |||
| 590 | 2347 | None | 64 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm1013693 | |||
| CHEMBL191 | 2347 | None | 64 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm1013693 | |||
| DB00678 | 2347 | None | 64 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -954 | 11 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm1013693 | |||
| 44355662 | 26470 | None | 0 | Rat | Functional | pIC50 | = | 5.7 | 5.7 | -125 | 2 | ChEMBL | 506 | 6 | 1 | 5 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 | 10.1021/jm00078a013 | |||
| CHEMBL135999 | 26470 | None | 0 | Rat | Functional | pIC50 | = | 5.7 | 5.7 | -125 | 2 | ChEMBL | 506 | 6 | 1 | 5 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 | 10.1021/jm00078a013 | |||
| 10411101 | 165760 | None | 0 | Rat | Functional | pIC50 | = | 4.7 | 4.7 | -676 | 2 | ChEMBL | 442 | 7 | 2 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 | 10.1021/jm00078a014 | |||
| CHEMBL424465 | 165760 | None | 0 | Rat | Functional | pIC50 | = | 4.7 | 4.7 | -676 | 2 | ChEMBL | 442 | 7 | 2 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 | 10.1021/jm00078a014 | |||
| 19742811 | 57438 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 1 | 3 | ChEMBL | 551 | 10 | 2 | 6 | 5.4 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm1013693 | |||
| CHEMBL165354 | 57438 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 1 | 3 | ChEMBL | 551 | 10 | 2 | 6 | 5.4 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm1013693 | |||
| 130762 | 98300 | None | 4 | Human | Functional | pIC50 | = | 6.7 | 6.7 | 1 | 6 | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm1013693 | |||
| CHEMBL274447 | 98300 | None | 4 | Human | Functional | pIC50 | = | 6.7 | 6.7 | 1 | 6 | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm1013693 | |||
| 192567 | 116716 | None | 4 | Rat | Functional | pIC50 | = | 6.7 | 6.7 | -223 | 2 | ChEMBL | 581 | 10 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00078a014 | |||
| CHEMBL337007 | 116716 | None | 4 | Rat | Functional | pIC50 | = | 6.7 | 6.7 | -223 | 2 | ChEMBL | 581 | 10 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00078a014 | |||
| 10366811 | 24834 | None | 0 | Rat | Functional | pIC50 | = | 5.7 | 5.7 | -31 | 2 | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 | 10.1021/jm00078a014 | |||
| CHEMBL134491 | 24834 | None | 0 | Rat | Functional | pIC50 | = | 5.7 | 5.7 | -31 | 2 | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 | 10.1021/jm00078a014 | |||
| 11744592 | 115567 | None | 0 | Rat | Functional | pIC50 | = | 4.7 | 4.7 | -33 | 2 | ChEMBL | 452 | 6 | 0 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 | 10.1021/jm00078a013 | |||
| CHEMBL335228 | 115567 | None | 0 | Rat | Functional | pIC50 | = | 4.7 | 4.7 | -33 | 2 | ChEMBL | 452 | 6 | 0 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 | 10.1021/jm00078a013 | |||
| 10409549 | 116042 | None | 0 | Rat | Functional | pIC50 | = | 4.7 | 4.7 | -104 | 2 | ChEMBL | 414 | 7 | 2 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | |||
| CHEMBL335514 | 116042 | None | 0 | Rat | Functional | pIC50 | = | 4.7 | 4.7 | -104 | 2 | ChEMBL | 414 | 7 | 2 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | |||
| 10027636 | 24602 | None | 0 | Rat | Functional | pIC50 | = | 5.7 | 5.7 | -70 | 2 | ChEMBL | 468 | 9 | 1 | 5 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | |||
| CHEMBL134286 | 24602 | None | 0 | Rat | Functional | pIC50 | = | 5.7 | 5.7 | -70 | 2 | ChEMBL | 468 | 9 | 1 | 5 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | |||
| 71455883 | 83797 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 495 | 6 | 2 | 7 | 4.7 | O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O | 10.1021/jm1013693 | |||
| CHEMBL2205685 | 83797 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 495 | 6 | 2 | 7 | 4.7 | O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O | 10.1021/jm1013693 | |||
| 10048602 | 26058 | None | 0 | Rat | Functional | pIC50 | = | 4.6 | 4.6 | -37 | 2 | ChEMBL | 435 | 4 | 0 | 5 | 4.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N | 10.1021/jm00078a013 | |||
| CHEMBL135522 | 26058 | None | 0 | Rat | Functional | pIC50 | = | 4.6 | 4.6 | -37 | 2 | ChEMBL | 435 | 4 | 0 | 5 | 4.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N | 10.1021/jm00078a013 | |||
| 9914666 | 116734 | None | 0 | Rat | Functional | pIC50 | = | 5.6 | 5.6 | -3388 | 2 | ChEMBL | 520 | 5 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 | 10.1021/jm00078a013 | |||
| CHEMBL337086 | 116734 | None | 0 | Rat | Functional | pIC50 | = | 5.6 | 5.6 | -3388 | 2 | ChEMBL | 520 | 5 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 | 10.1021/jm00078a013 | |||
| 9846535 | 57532 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 427 | 5 | 2 | 4 | 5.4 | O=C(O)c1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1 | 10.1021/jm1013693 | |||
| CHEMBL166143 | 57532 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 427 | 5 | 2 | 4 | 5.4 | O=C(O)c1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1 | 10.1021/jm1013693 | |||
| 10326140 | 116715 | None | 0 | Rat | Functional | pIC50 | = | 5.5 | 5.5 | -2884 | 2 | ChEMBL | 593 | 11 | 1 | 7 | 5.9 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | |||
| CHEMBL337006 | 116715 | None | 0 | Rat | Functional | pIC50 | = | 5.5 | 5.5 | -2884 | 2 | ChEMBL | 593 | 11 | 1 | 7 | 5.9 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | |||
| 10365283 | 25861 | None | 0 | Rat | Functional | pIC50 | = | 5.5 | 5.5 | -416 | 2 | ChEMBL | 428 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | |||
| CHEMBL135345 | 25861 | None | 0 | Rat | Functional | pIC50 | = | 5.5 | 5.5 | -416 | 2 | ChEMBL | 428 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | |||
| 10393717 | 116163 | None | 0 | Rat | Functional | pIC50 | = | 6.4 | 6.4 | -524 | 2 | ChEMBL | 595 | 11 | 1 | 7 | 6.1 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | |||
| CHEMBL335722 | 116163 | None | 0 | Rat | Functional | pIC50 | = | 6.4 | 6.4 | -524 | 2 | ChEMBL | 595 | 11 | 1 | 7 | 6.1 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | |||
| 10344571 | 116678 | None | 0 | Rat | Functional | pIC50 | = | 5.4 | 5.4 | -125 | 2 | ChEMBL | 468 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | |||
| CHEMBL336773 | 116678 | None | 0 | Rat | Functional | pIC50 | = | 5.4 | 5.4 | -125 | 2 | ChEMBL | 468 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | |||
| 10027714 | 115501 | None | 0 | Rat | Functional | pIC50 | = | 5.3 | 5.3 | -398 | 2 | ChEMBL | 470 | 9 | 1 | 5 | 6.0 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | |||
| CHEMBL335066 | 115501 | None | 0 | Rat | Functional | pIC50 | = | 5.3 | 5.3 | -398 | 2 | ChEMBL | 470 | 9 | 1 | 5 | 6.0 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | |||
| 10004112 | 25538 | None | 0 | Rat | Functional | pIC50 | = | 6.3 | 6.3 | -93 | 2 | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | |||
| CHEMBL135089 | 25538 | None | 0 | Rat | Functional | pIC50 | = | 6.3 | 6.3 | -93 | 2 | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | |||
| 10344052 | 116671 | None | 0 | Rat | Functional | pIC50 | = | 6.3 | 6.3 | -107 | 2 | ChEMBL | 456 | 9 | 1 | 5 | 5.7 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | |||
| CHEMBL336738 | 116671 | None | 0 | Rat | Functional | pIC50 | = | 6.3 | 6.3 | -107 | 2 | ChEMBL | 456 | 9 | 1 | 5 | 5.7 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | |||
| 10437543 | 26275 | None | 0 | Rat | Functional | pIC50 | = | 5.2 | 5.2 | -7 | 2 | ChEMBL | 550 | 7 | 2 | 5 | 6.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | |||
| CHEMBL135819 | 26275 | None | 0 | Rat | Functional | pIC50 | = | 5.2 | 5.2 | -7 | 2 | ChEMBL | 550 | 7 | 2 | 5 | 6.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | |||
| 10414429 | 116061 | None | 0 | Rat | Functional | pIC50 | = | 5.2 | 5.2 | -363 | 2 | ChEMBL | 522 | 5 | 1 | 5 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O | 10.1021/jm00078a013 | |||
| CHEMBL335535 | 116061 | None | 0 | Rat | Functional | pIC50 | = | 5.2 | 5.2 | -363 | 2 | ChEMBL | 522 | 5 | 1 | 5 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O | 10.1021/jm00078a013 | |||
| 10434876 | 116682 | None | 0 | Rat | Functional | pIC50 | = | 6.2 | 6.2 | -7 | 2 | ChEMBL | 470 | 10 | 1 | 5 | 6.1 | CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | |||
| CHEMBL336808 | 116682 | None | 0 | Rat | Functional | pIC50 | = | 6.2 | 6.2 | -7 | 2 | ChEMBL | 470 | 10 | 1 | 5 | 6.1 | CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | |||
| 10026868 | 23867 | None | 0 | Rat | Functional | pIC50 | = | 5.2 | 5.2 | -331 | 2 | ChEMBL | 452 | 5 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 | 10.1021/jm00078a013 | |||
| CHEMBL133653 | 23867 | None | 0 | Rat | Functional | pIC50 | = | 5.2 | 5.2 | -331 | 2 | ChEMBL | 452 | 5 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 | 10.1021/jm00078a013 | |||
| 10456041 | 25863 | None | 0 | Rat | Functional | pIC50 | = | 6.1 | 6.1 | -186 | 2 | ChEMBL | 442 | 8 | 1 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | |||
| CHEMBL135346 | 25863 | None | 0 | Rat | Functional | pIC50 | = | 6.1 | 6.1 | -186 | 2 | ChEMBL | 442 | 8 | 1 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | |||
| 10095589 | 115583 | None | 0 | Rat | Functional | pIC50 | = | 5.1 | 5.1 | -851 | 2 | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | |||
| CHEMBL335289 | 115583 | None | 0 | Rat | Functional | pIC50 | = | 5.1 | 5.1 | -851 | 2 | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | |||
| 10345459 | 116834 | None | 0 | Rat | Functional | pIC50 | = | 5.1 | 5.1 | -43 | 2 | ChEMBL | 490 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F | 10.1021/jm00078a014 | |||
| CHEMBL337663 | 116834 | None | 0 | Rat | Functional | pIC50 | = | 5.1 | 5.1 | -43 | 2 | ChEMBL | 490 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F | 10.1021/jm00078a014 | |||
| 10250898 | 118552 | None | 0 | Rat | Functional | pIC50 | = | 5.1 | 5.1 | -37 | 2 | ChEMBL | 408 | 4 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 | 10.1021/jm00078a013 | |||
| CHEMBL341407 | 118552 | None | 0 | Rat | Functional | pIC50 | = | 5.1 | 5.1 | -37 | 2 | ChEMBL | 408 | 4 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 | 10.1021/jm00078a013 | |||
| 10071193 | 206782 | None | 0 | Rat | Functional | pKd | = | 8.7 | 8.7 | - | 0 | ChEMBL | 427 | 7 | 1 | 4 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc([C@H](c2ccccc2)[C@H](C)C(=O)O)cc1 | 10.1021/jm9508853 | |||
| CHEMBL71485 | 206782 | None | 0 | Rat | Functional | pKd | = | 8.7 | 8.7 | - | 0 | ChEMBL | 427 | 7 | 1 | 4 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc([C@H](c2ccccc2)[C@H](C)C(=O)O)cc1 | 10.1021/jm9508853 | |||
| 6918 | 1028 | None | 34 | Human | Functional | pKi | = | 8.7 | 8.7 | -7 | 2 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| 9804984 | 1028 | None | 34 | Human | Functional | pKi | = | 8.7 | 8.7 | -7 | 2 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL189568 | 1028 | None | 34 | Human | Functional | pKi | = | 8.7 | 8.7 | -7 | 2 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| 6918 | 1028 | None | 34 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -7 | 2 | Guide to Pharmacology | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 22802221 | |||
| 9804984 | 1028 | None | 34 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -7 | 2 | Guide to Pharmacology | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 22802221 | |||
| CHEMBL189568 | 1028 | None | 34 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -7 | 2 | Guide to Pharmacology | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 22802221 | |||
| 6918 | 1028 | None | 34 | Rat | Functional | pEC50 | = | 5.7 | 5.7 | 7 | 2 | Guide to Pharmacology | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 22802221 | |||
| 9804984 | 1028 | None | 34 | Rat | Functional | pEC50 | = | 5.7 | 5.7 | 7 | 2 | Guide to Pharmacology | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 22802221 | |||
| CHEMBL189568 | 1028 | None | 34 | Rat | Functional | pEC50 | = | 5.7 | 5.7 | 7 | 2 | Guide to Pharmacology | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 22802221 | |||
| 1610 | 2347 | None | 64 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -2884 | 11 | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3941 | 2347 | None | 64 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -2884 | 11 | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961 | 2347 | None | 64 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -2884 | 11 | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961.0 | 2347 | None | 64 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -2884 | 11 | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 590 | 2347 | None | 64 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -2884 | 11 | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| CHEMBL191 | 2347 | None | 64 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -2884 | 11 | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| DB00678 | 2347 | None | 64 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -2884 | 11 | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 36736 | 3474 | None | 0 | Rat | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 2 | Drug Central | None | None | None | None | None | |||||
| 598 | 3474 | None | 0 | Rat | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 2 | Drug Central | None | None | None | None | None | |||||
| 6324663 | 3474 | None | 0 | Rat | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 2 | Drug Central | None | None | None | None | None | |||||
| CHEMBL356431 | 3474 | None | 0 | Rat | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 2 | Drug Central | None | None | None | None | None | |||||
| 123805 | 417 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | -35 | 2 | Guide to Pharmacology | None | None | None | None | 21542804 | |||||
| 123805.0 | 417 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | -35 | 2 | Guide to Pharmacology | None | None | None | None | 21542804 | |||||
| 46878481 | 417 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | -35 | 2 | Guide to Pharmacology | None | None | None | None | 21542804 | |||||
| 5578 | 417 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | -35 | 2 | Guide to Pharmacology | None | None | None | None | 21542804 | |||||
| 582 | 417 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | -35 | 2 | Guide to Pharmacology | None | None | None | None | 21542804 | |||||
| CHEMBL3545347 | 417 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | -35 | 2 | Guide to Pharmacology | None | None | None | None | 21542804 | |||||
| DB11720 | 417 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | -35 | 2 | Guide to Pharmacology | None | None | None | None | 21542804 | |||||
| 8374 | 2922 | None | 43 | Rat | Functional | pIC50 | = | 7.5 | 7.5 | -38 | 3 | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 23489258 | |||
| 9937291 | 2922 | None | 43 | Rat | Functional | pIC50 | = | 7.5 | 7.5 | -38 | 3 | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 23489258 | |||
| CHEMBL34124 | 2922 | None | 43 | Rat | Functional | pIC50 | = | 7.5 | 7.5 | -38 | 3 | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 23489258 | |||
| DB16266 | 2922 | None | 43 | Rat | Functional | pIC50 | = | 7.5 | 7.5 | -38 | 3 | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 23489258 | |||
| 8374 | 2922 | None | 43 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 38 | 3 | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 23489258 | |||
| 8374 | 2922 | None | 43 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 38 | 3 | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 24507377 | |||
| 8374 | 2922 | None | 43 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 38 | 3 | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 24507378 | |||
| 9937291 | 2922 | None | 43 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 38 | 3 | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 23489258 | |||
| 9937291 | 2922 | None | 43 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 38 | 3 | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 24507377 | |||
| 9937291 | 2922 | None | 43 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 38 | 3 | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 24507378 | |||
| CHEMBL34124 | 2922 | None | 43 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 38 | 3 | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 23489258 | |||
| CHEMBL34124 | 2922 | None | 43 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 38 | 3 | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 24507377 | |||
| CHEMBL34124 | 2922 | None | 43 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 38 | 3 | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 24507378 | |||
| DB16266 | 2922 | None | 43 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 38 | 3 | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 23489258 | |||
| DB16266 | 2922 | None | 43 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 38 | 3 | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 24507377 | |||
| DB16266 | 2922 | None | 43 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 38 | 3 | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 24507378 | |||
| 114899 | 3020 | None | 15 | Rat | Functional | pIC50 | = | 9.0 | 9.0 | 64 | 2 | Guide to Pharmacology | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 2314387 | |||
| 114899 | 3020 | None | 15 | Rat | Functional | pIC50 | = | 9.0 | 9.0 | 64 | 2 | Guide to Pharmacology | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 2590220 | |||
| 114899 | 3020 | None | 15 | Rat | Functional | pIC50 | = | 9.0 | 9.0 | 64 | 2 | Guide to Pharmacology | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 8469774 | |||
| 596 | 3020 | None | 15 | Rat | Functional | pIC50 | = | 9.0 | 9.0 | 64 | 2 | Guide to Pharmacology | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 2314387 | |||
| 596 | 3020 | None | 15 | Rat | Functional | pIC50 | = | 9.0 | 9.0 | 64 | 2 | Guide to Pharmacology | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 2590220 | |||
| 596 | 3020 | None | 15 | Rat | Functional | pIC50 | = | 9.0 | 9.0 | 64 | 2 | Guide to Pharmacology | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 8469774 | |||
| CHEMBL1188080 | 3020 | None | 15 | Rat | Functional | pIC50 | = | 9.0 | 9.0 | 64 | 2 | Guide to Pharmacology | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 2314387 | |||
| CHEMBL1188080 | 3020 | None | 15 | Rat | Functional | pIC50 | = | 9.0 | 9.0 | 64 | 2 | Guide to Pharmacology | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 2590220 | |||
| CHEMBL1188080 | 3020 | None | 15 | Rat | Functional | pIC50 | = | 9.0 | 9.0 | 64 | 2 | Guide to Pharmacology | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 8469774 | |||
| 36736 | 3474 | None | 0 | Rat | Functional | pIC50 | = | 9 | 9.0 | 2 | 2 | Guide to Pharmacology | None | None | None | None | 2590220 | |||||
| 598 | 3474 | None | 0 | Rat | Functional | pIC50 | = | 9 | 9.0 | 2 | 2 | Guide to Pharmacology | None | None | None | None | 2590220 | |||||
| 6324663 | 3474 | None | 0 | Rat | Functional | pIC50 | = | 9 | 9.0 | 2 | 2 | Guide to Pharmacology | None | None | None | None | 2590220 | |||||
| CHEMBL356431 | 3474 | None | 0 | Rat | Functional | pIC50 | = | 9 | 9.0 | 2 | 2 | Guide to Pharmacology | None | None | None | None | 2590220 | |||||
| 123794 | 893 | None | 40 | Human | Functional | pIC50 | = | 9.6 | 9.6 | - | 1 | Guide to Pharmacology | None | None | None | None | 21542804 | |||||
| 3944 | 893 | None | 40 | Human | Functional | pIC50 | = | 9.6 | 9.6 | - | 1 | Guide to Pharmacology | None | None | None | None | 21542804 | |||||
| 594 | 893 | None | 40 | Human | Functional | pIC50 | = | 9.6 | 9.6 | - | 1 | Guide to Pharmacology | None | None | None | None | 21542804 | |||||
| CHEMBL1885579 | 893 | None | 40 | Human | Functional | pIC50 | = | 9.6 | 9.6 | - | 1 | Guide to Pharmacology | None | None | None | None | 21542804 | |||||
| 6894 | 418 | None | 0 | Human | Functional | pIC50 | = | 9.9 | 9.9 | 2 | 3 | Guide to Pharmacology | None | None | None | None | 17138938 | |||||
| 91691124 | 418 | None | 0 | Human | Functional | pIC50 | = | 9.9 | 9.9 | 2 | 3 | Guide to Pharmacology | None | None | None | None | 17138938 | |||||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 44348523 | 113242 | None | 0 | Rat | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL331450 | 113242 | None | 0 | Rat | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 11930 | 1019 | None | 0 | Rat | Binding | pIC50 | = | 10.2 | 10.2 | - | 2 | ChEMBL | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 10.1016/S0960-894X(01)80517-5 | |||
| 15780052 | 1019 | None | 0 | Rat | Binding | pIC50 | = | 10.2 | 10.2 | - | 2 | ChEMBL | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL289472 | 1019 | None | 0 | Rat | Binding | pIC50 | = | 10.2 | 10.2 | - | 2 | ChEMBL | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 10.1016/S0960-894X(01)80517-5 | |||
| 10033116 | 210695 | None | 0 | Rat | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 766 | 17 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| CHEMBL98665 | 210695 | None | 0 | Rat | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 766 | 17 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| 11765177 | 117072 | None | 0 | Rat | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338888 | 117072 | None | 0 | Rat | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 16133225 | 419 | None | 38 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| 172198 | 419 | None | 38 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| 172198.0 | 419 | None | 38 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| 2504 | 419 | None | 38 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| 45266664 | 419 | None | 38 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| 5272 | 419 | None | 38 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| CHEMBL408403 | 419 | None | 38 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| DB11842 | 419 | None | 38 | Human | Binding | pIC50 | = | 10.1 | 10.1 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| CHEMBL385433 | 214810 | None | 1 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmc.2016.03.006 | |||||
| 10259841 | 16165 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122401 | 16165 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10417195 | 109135 | None | 0 | Rat | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL321313 | 109135 | None | 0 | Rat | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10078554 | 117032 | None | 0 | Rat | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338687 | 117032 | None | 0 | Rat | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10440174 | 167917 | None | 0 | Rat | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 767 | 17 | 1 | 9 | 8.0 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| CHEMBL430659 | 167917 | None | 0 | Rat | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 767 | 17 | 1 | 9 | 8.0 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| CHEMBL385189 | 214803 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cccs1)C(=O)O | 10.1021/jm00108a043 | |||||
| 10078800 | 109247 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL321531 | 109247 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 9853391 | 116903 | None | 1 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338027 | 116903 | None | 1 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 9853391 | 116903 | None | 1 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm9504722 | |||
| CHEMBL338027 | 116903 | None | 1 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm9504722 | |||
| CHEMBL2391146 | 212871 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2013.03.016 | |||||
| 10101351 | 168767 | None | 0 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL436396 | 168767 | None | 0 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10259525 | 15626 | None | 0 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL122158 | 15626 | None | 0 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10372810 | 106258 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL313868 | 106258 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10078800 | 109247 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL321531 | 109247 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10395335 | 117146 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339256 | 117146 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 10033136 | 16080 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122380 | 16080 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 19430477 | 210590 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 732 | 18 | 1 | 8 | 8.1 | CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1ccccc1 | 10.1021/jm00015a016 | |||
| CHEMBL98047 | 210590 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 732 | 18 | 1 | 8 | 8.1 | CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1ccccc1 | 10.1021/jm00015a016 | |||
| 10259468 | 118545 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL341369 | 118545 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10101606 | 15778 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122273 | 15778 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10032988 | 116981 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338434 | 116981 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10440179 | 107455 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 768 | 17 | 1 | 10 | 7.4 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| CHEMBL317962 | 107455 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 768 | 17 | 1 | 10 | 7.4 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| 10078780 | 116980 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338433 | 116980 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10259468 | 118545 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL341369 | 118545 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10259265 | 110099 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL323506 | 110099 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10372659 | 118154 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL340632 | 118154 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10327728 | 98175 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL273542 | 98175 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10078554 | 117032 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338687 | 117032 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10033116 | 210695 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 766 | 17 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| CHEMBL98665 | 210695 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 766 | 17 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| 44348523 | 113242 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL331450 | 113242 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10032877 | 15556 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL121907 | 15556 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 183134 | 207302 | None | 16 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL7550 | 207302 | None | 16 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 10259525 | 15626 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL122158 | 15626 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10010071 | 117413 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339722 | 117413 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 15292111 | 207203 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74442 | 207203 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL2392353 | 212873 | None | 5 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | None | None | None | None | 10.1016/j.ejmech.2013.01.044 | |||||
| 10033136 | 16080 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122380 | 16080 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10439837 | 16360 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL122917 | 16360 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10032820 | 117368 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339672 | 117368 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 9853391 | 116903 | None | 1 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338027 | 116903 | None | 1 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10101690 | 116925 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338137 | 116925 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10440144 | 116958 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338342 | 116958 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10439715 | 117099 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339040 | 117099 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44314761 | 102909 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL305647 | 102909 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44315344 | 105137 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311386 | 105137 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44315078 | 207214 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74556 | 207214 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 15780085 | 118214 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 617 | 9 | 1 | 7 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL34082 | 118214 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 617 | 9 | 1 | 7 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 10440144 | 116958 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338342 | 116958 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10032988 | 116981 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338434 | 116981 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10101351 | 168767 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL436396 | 168767 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44315078 | 207214 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74556 | 207214 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10033126 | 168240 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 768 | 17 | 1 | 10 | 7.4 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| CHEMBL433005 | 168240 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 768 | 17 | 1 | 10 | 7.4 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| 10078780 | 116980 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338433 | 116980 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10372451 | 117358 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339605 | 117358 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10462683 | 113345 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331507 | 113345 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44283480 | 100522 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 637 | 9 | 1 | 8 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL290768 | 100522 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 637 | 9 | 1 | 8 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 10259265 | 110099 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL323506 | 110099 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10259265 | 110099 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL323506 | 110099 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10462933 | 16889 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL125008 | 16889 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 19754068 | 102788 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 643 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL304946 | 102788 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 643 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| 10101606 | 15778 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122273 | 15778 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10101608 | 117093 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL339004 | 117093 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44315282 | 96677 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL263452 | 96677 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| 44315351 | 104941 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311160 | 104941 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 9896750 | 4181 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 733 | 18 | 1 | 9 | 7.5 | CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 | 10.1021/jm00015a016 | |||
| CHEMBL100119 | 4181 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 733 | 18 | 1 | 9 | 7.5 | CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 | 10.1021/jm00015a016 | |||
| 10372550 | 164611 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL421478 | 164611 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10439715 | 117099 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339040 | 117099 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9987414 | 117113 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339113 | 117113 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 11765177 | 117072 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338888 | 117072 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10032851 | 16842 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL124771 | 16842 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44314761 | 102909 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL305647 | 102909 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9896750 | 4181 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 733 | 18 | 1 | 9 | 7.5 | CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 | 10.1021/jm9504722 | |||
| CHEMBL100119 | 4181 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 733 | 18 | 1 | 9 | 7.5 | CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 | 10.1021/jm9504722 | |||
| 10032877 | 15556 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL121907 | 15556 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10009984 | 113243 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331455 | 113243 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10078475 | 113393 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331632 | 113393 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9987414 | 117113 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339113 | 117113 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10010164 | 117461 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL339806 | 117461 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 11765560 | 15544 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL121872 | 15544 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44314822 | 103004 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL306362 | 103004 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9895877 | 53905 | None | 1 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 653 | 12 | 2 | 8 | 7.1 | CCCc1nc2c(C)c(NC(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1021/jm9504722 | |||
| CHEMBL160494 | 53905 | None | 1 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 653 | 12 | 2 | 8 | 7.1 | CCCc1nc2c(C)c(NC(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1021/jm9504722 | |||
| 10439858 | 16868 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL124903 | 16868 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10259447 | 16935 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL125280 | 16935 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | |||
| 10010071 | 117413 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339722 | 117413 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 15292111 | 207203 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74442 | 207203 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 19754061 | 102789 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 657 | 15 | 2 | 7 | 7.7 | CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL304947 | 102789 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 657 | 15 | 2 | 7 | 7.7 | CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | |||
| 10462573 | 117073 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338889 | 117073 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10395335 | 117146 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339256 | 117146 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 44315349 | 60410 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL17487 | 60410 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10394859 | 17436 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL125760 | 17436 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 2583 | 3776 | None | 69 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| 592 | 3776 | None | 69 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| 65999 | 3776 | None | 69 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| 65999.0 | 3776 | None | 69 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1017 | 3776 | None | 69 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| DB00966 | 3776 | None | 69 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| 10373120 | 117665 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL340078 | 117665 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 10394859 | 17436 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL125760 | 17436 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44315351 | 104941 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311160 | 104941 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 15780090 | 100509 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 631 | 9 | 1 | 7 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL290669 | 100509 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 631 | 9 | 1 | 7 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 10101608 | 117093 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL339004 | 117093 | None | 0 | Rat | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10259841 | 16165 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122401 | 16165 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10372659 | 118154 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL340632 | 118154 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44314822 | 103004 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL306362 | 103004 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10373120 | 117665 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL340078 | 117665 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 44315144 | 96645 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL263191 | 96645 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10032851 | 16842 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL124771 | 16842 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10395076 | 168679 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL435811 | 168679 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9874508 | 207138 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL73876 | 207138 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9874508 | 207138 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1021/jm9504722 | |||
| CHEMBL73876 | 207138 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1021/jm9504722 | |||
| 44338708 | 110507 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| CHEMBL324629 | 110507 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| 22850667 | 203256 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 542 | 11 | 1 | 3 | 6.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL60071 | 203256 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 542 | 11 | 1 | 3 | 6.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 10032820 | 117368 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339672 | 117368 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 10462683 | 113345 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331507 | 113345 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44314823 | 161980 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL415073 | 161980 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL938 | 218397 | None | 23 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm8007618 | |||||
| 9809637 | 206310 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 643 | 15 | 2 | 7 | 7.4 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL68618 | 206310 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 643 | 15 | 2 | 7 | 7.4 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 9830680 | 100697 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm990504b | |||
| CHEMBL292150 | 100697 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm990504b | |||
| 15780094 | 99864 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 651 | 9 | 1 | 7 | 7.4 | CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL285433 | 99864 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 651 | 9 | 1 | 7 | 7.4 | CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL384352 | 214784 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CCSS2 | 10.1021/jm00065a013 | |||||
| 9917295 | 103013 | None | 18 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 633 | 15 | 2 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL306407 | 103013 | None | 18 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 633 | 15 | 2 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 10417321 | 15625 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122157 | 15625 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10439819 | 169992 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL444065 | 169992 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 15292113 | 96086 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL259843 | 96086 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10078800 | 109247 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL321531 | 109247 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10485034 | 107242 | None | 1 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 719 | 17 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)CCN(C(=O)CC)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| CHEMBL316503 | 107242 | None | 1 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 719 | 17 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)CCN(C(=O)CC)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| 15292113 | 96086 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL259843 | 96086 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10462598 | 114200 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL332909 | 114200 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | |||
| 10259447 | 16935 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL125280 | 16935 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL938 | 218397 | None | 23 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -1 | 2 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmc.2010.07.034 | |||||
| 10462933 | 16889 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL125008 | 16889 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10462598 | 114200 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL332909 | 114200 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | |||
| 10009984 | 113243 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331455 | 113243 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | |||
| 15292112 | 103003 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL306361 | 103003 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44314780 | 103133 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL307430 | 103133 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10101690 | 116925 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338137 | 116925 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 8374 | 2922 | None | 43 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/S0960-894X(01)80517-5 | |||
| 9937291 | 2922 | None | 43 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL34124 | 2922 | None | 43 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/S0960-894X(01)80517-5 | |||
| DB16266 | 2922 | None | 43 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/S0960-894X(01)80517-5 | |||
| 10327309 | 113955 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL332576 | 113955 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1021/jm00019a004 | |||
| 10372451 | 117358 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339605 | 117358 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 8374 | 2922 | None | 43 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/S0960-894X(01)81122-7 | |||
| 9937291 | 2922 | None | 43 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL34124 | 2922 | None | 43 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/S0960-894X(01)81122-7 | |||
| DB16266 | 2922 | None | 43 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/S0960-894X(01)81122-7 | |||
| 44338834 | 7860 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL108981 | 7860 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 44338834 | 7860 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL108981 | 7860 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 44303887 | 205779 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL64861 | 205779 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 8374 | 2922 | None | 43 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm9504722 | |||
| 9937291 | 2922 | None | 43 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm9504722 | |||
| CHEMBL34124 | 2922 | None | 43 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm9504722 | |||
| DB16266 | 2922 | None | 43 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm9504722 | |||
| 44315344 | 105137 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311386 | 105137 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 16133225 | 419 | None | 38 | Human | Binding | pIC50 | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| 172198 | 419 | None | 38 | Human | Binding | pIC50 | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| 172198.0 | 419 | None | 38 | Human | Binding | pIC50 | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| 2504 | 419 | None | 38 | Human | Binding | pIC50 | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| 45266664 | 419 | None | 38 | Human | Binding | pIC50 | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| 5272 | 419 | None | 38 | Human | Binding | pIC50 | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| CHEMBL408403 | 419 | None | 38 | Human | Binding | pIC50 | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| DB11842 | 419 | None | 38 | Human | Binding | pIC50 | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| 11765454 | 118132 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL340473 | 118132 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10349897 | 114492 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL333224 | 114492 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44315058 | 70477 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL194608 | 70477 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44315059 | 207170 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74144 | 207170 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10101606 | 15778 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122273 | 15778 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL385283 | 214807 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CCSS[C@@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00065a013 | |||||
| 19430475 | 206710 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 787 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71125 | 206710 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 787 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 9940350 | 207216 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | |||
| CHEMBL74573 | 207216 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | |||
| 9851889 | 102129 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| CHEMBL302102 | 102129 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| 9940350 | 207216 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL74573 | 207216 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 10031067 | 100406 | None | 4 | Human | Binding | pIC50 | = | 9.2 | 9.2 | -2 | 3 | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | |||
| CHEMBL289614 | 100406 | None | 4 | Human | Binding | pIC50 | = | 9.2 | 9.2 | -2 | 3 | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | |||
| 10031067 | 100406 | None | 4 | Human | Binding | pIC50 | = | 9.2 | 9.2 | -2 | 3 | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmcl.2015.10.084 | |||
| CHEMBL289614 | 100406 | None | 4 | Human | Binding | pIC50 | = | 9.2 | 9.2 | -2 | 3 | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmcl.2015.10.084 | |||
| 10031067 | 100406 | None | 4 | Human | Binding | pIC50 | = | 9.2 | 9.2 | -2 | 3 | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm031031i | |||
| CHEMBL289614 | 100406 | None | 4 | Human | Binding | pIC50 | = | 9.2 | 9.2 | -2 | 3 | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm031031i | |||
| 44283174 | 100128 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 617 | 9 | 1 | 7 | 7.2 | CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL287250 | 100128 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 617 | 9 | 1 | 7 | 7.2 | CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 9851889 | 102129 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL302102 | 102129 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)80595-3 | |||
| 9851889 | 102129 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL302102 | 102129 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81115-X | |||
| 9851889 | 102129 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00019a004 | |||
| CHEMBL302102 | 102129 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00019a004 | |||
| 10395076 | 168679 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL435811 | 168679 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44315058 | 70477 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL194608 | 70477 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9851889 | 102129 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL302102 | 102129 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44303886 | 100934 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 522 | 11 | 1 | 3 | 6.1 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL293660 | 100934 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 522 | 11 | 1 | 3 | 6.1 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 9851889 | 102129 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL302102 | 102129 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | |||
| 9851889 | 102129 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm9504722 | |||
| CHEMBL302102 | 102129 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm9504722 | |||
| 9851889 | 102129 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm058225d | |||
| CHEMBL302102 | 102129 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm058225d | |||
| 44315057 | 207287 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL75401 | 207287 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10078475 | 113393 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331632 | 113393 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44283175 | 120434 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 637 | 8 | 1 | 7 | 7.1 | Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL35324 | 120434 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 637 | 8 | 1 | 7 | 7.1 | Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 44315304 | 207468 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL76821 | 207468 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44314823 | 161980 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL415073 | 161980 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 9874508 | 207138 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL73876 | 207138 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10439819 | 169992 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL444065 | 169992 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44338697 | 109715 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 613 | 11 | 1 | 8 | 6.8 | CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| CHEMBL322471 | 109715 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 613 | 11 | 1 | 8 | 6.8 | CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| 10372550 | 164611 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL421478 | 164611 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 15292112 | 103003 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL306361 | 103003 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44314780 | 103133 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL307430 | 103133 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10462573 | 117073 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338889 | 117073 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL414533 | 215596 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CSS[C@@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00065a013 | |||||
| 10259265 | 110099 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL323506 | 110099 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10327309 | 113955 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL332576 | 113955 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1021/jm00019a004 | |||
| 10439837 | 16360 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL122917 | 16360 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9892451 | 48754 | None | 24 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL155836 | 48754 | None | 24 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| 10010164 | 117461 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL339806 | 117461 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10032988 | 116981 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338434 | 116981 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 11765454 | 118132 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL340473 | 118132 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10100951 | 115108 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL334300 | 115108 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| 20647138 | 100526 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 520 | 5 | 1 | 3 | 6.0 | O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL290829 | 100526 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 520 | 5 | 1 | 3 | 6.0 | O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | |||
| 9918412 | 206720 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 739 | 16 | 1 | 9 | 8.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71172 | 206720 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 739 | 16 | 1 | 9 | 8.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 19430479 | 206727 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71220 | 206727 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 10462053 | 168160 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 664 | 15 | 4 | 8 | 5.9 | CCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL432378 | 168160 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 664 | 15 | 4 | 8 | 5.9 | CCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 10327728 | 98175 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL273542 | 98175 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44315282 | 96677 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL263452 | 96677 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| 9917399 | 102201 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL302519 | 102201 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| 9917399 | 102201 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1021/jm9504722 | |||
| CHEMBL302519 | 102201 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1021/jm9504722 | |||
| 44315349 | 60410 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL17487 | 60410 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44311675 | 102209 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL302579 | 102209 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311676 | 103116 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 706 | 17 | 2 | 9 | 7.0 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL307318 | 103116 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 706 | 17 | 2 | 9 | 7.0 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311412 | 105385 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 725 | 17 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL311625 | 105385 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 725 | 17 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311072 | 206644 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 679 | 15 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70789 | 206644 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 679 | 15 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311736 | 206665 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70867 | 206665 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311452 | 206963 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 739 | 15 | 1 | 9 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL72595 | 206963 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 739 | 15 | 1 | 9 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 15780095 | 98648 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 595 | 9 | 1 | 7 | 6.5 | CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL276853 | 98648 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 595 | 9 | 1 | 7 | 6.5 | CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 15780091 | 121060 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 618 | 9 | 1 | 8 | 6.1 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL35638 | 121060 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 618 | 9 | 1 | 8 | 6.1 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 9851082 | 101074 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL294512 | 101074 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(01)80554-0 | |||
| 9810305 | 98625 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL276674 | 98625 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 9810305 | 98625 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL276674 | 98625 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| 1037 | 1578 | None | 44 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1021/jm00108a043 | |||
| 3940 | 1578 | None | 44 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1021/jm00108a043 | |||
| 5281037 | 1578 | None | 44 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1021/jm00108a043 | |||
| 5281037.0 | 1578 | None | 44 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1021/jm00108a043 | |||
| 588 | 1578 | None | 44 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1021/jm00108a043 | |||
| CHEMBL813 | 1578 | None | 44 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1021/jm00108a043 | |||
| DB00876 | 1578 | None | 44 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1021/jm00108a043 | |||
| 9810305 | 98625 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL276674 | 98625 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| 44315144 | 96645 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL263191 | 96645 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9851082 | 101074 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | |||
| CHEMBL294512 | 101074 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | |||
| 10395395 | 107350 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 768 | 17 | 1 | 10 | 7.4 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| CHEMBL317159 | 107350 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 768 | 17 | 1 | 10 | 7.4 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| 10033013 | 111716 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 750 | 17 | 1 | 10 | 7.3 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1021/jm00015a016 | |||
| CHEMBL328602 | 111716 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 750 | 17 | 1 | 10 | 7.3 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1021/jm00015a016 | |||
| 9937227 | 204629 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 543 | 12 | 1 | 7 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 | 10.1021/jm00015a016 | |||
| CHEMBL60942 | 204629 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 543 | 12 | 1 | 7 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 | 10.1021/jm00015a016 | |||
| 10078661 | 210706 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 733 | 17 | 1 | 9 | 7.4 | CCCc1nc(CC)c(C(=O)CCN(C(=O)C(C)C)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| CHEMBL98746 | 210706 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 733 | 17 | 1 | 9 | 7.4 | CCCc1nc(CC)c(C(=O)CCN(C(=O)C(C)C)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| 10259277 | 210773 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 715 | 18 | 1 | 9 | 7.4 | CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1)c1cccnc1 | 10.1021/jm00015a016 | |||
| CHEMBL99112 | 210773 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 715 | 18 | 1 | 9 | 7.4 | CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1)c1cccnc1 | 10.1021/jm00015a016 | |||
| 44315304 | 207468 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL76821 | 207468 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44315057 | 207287 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL75401 | 207287 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 24755620 | 194721 | None | 6 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 846 | 21 | 4 | 9 | 8.0 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)[C@H](C(=O)O)C(C)C.CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)O | 10.1016/j.ejmech.2019.111852 | |||
| CHEMBL5272027 | 194721 | None | 6 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 846 | 21 | 4 | 9 | 8.0 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)[C@H](C(=O)O)C(C)C.CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)O | 10.1016/j.ejmech.2019.111852 | |||
| CHEMBL5315276 | 194721 | None | 6 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 846 | 21 | 4 | 9 | 8.0 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)[C@H](C(=O)O)C(C)C.CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)O | 10.1016/j.ejmech.2019.111852 | |||
| 44322202 | 106927 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 692 | 17 | 4 | 8 | 6.7 | CCCCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL314506 | 106927 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 692 | 17 | 4 | 8 | 6.7 | CCCCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 44322203 | 106990 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 650 | 13 | 4 | 8 | 5.4 | CCCc1nc(SC)c(C(O)(C(=O)O)C(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL314827 | 106990 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 650 | 13 | 4 | 8 | 5.4 | CCCc1nc(SC)c(C(O)(C(=O)O)C(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 44321791 | 209071 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 698 | 14 | 4 | 8 | 6.0 | CCCc1nc(SC)c(C(O)(Cc2ccccc2)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL89053 | 209071 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 698 | 14 | 4 | 8 | 6.0 | CCCc1nc(SC)c(C(O)(Cc2ccccc2)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 10078554 | 117032 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338687 | 117032 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 11765560 | 15544 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL121872 | 15544 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10417321 | 15625 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122157 | 15625 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 9810305 | 98625 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL276674 | 98625 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| 10485116 | 116917 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338101 | 116917 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00019a004 | |||
| 18965174 | 100922 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 507 | 12 | 1 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)C(C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL293625 | 100922 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 507 | 12 | 1 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)C(C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 9870559 | 46882 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 499 | 8 | 1 | 4 | 5.6 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)C1CCCC1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL154057 | 46882 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 499 | 8 | 1 | 4 | 5.6 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)C1CCCC1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| 19939495 | 210284 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96314 | 210284 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10010071 | 117413 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339722 | 117413 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL216061 | 211775 | None | 17 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm00108a043 | |||||
| 10395335 | 117146 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339256 | 117146 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 10349897 | 114492 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL333224 | 114492 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10439858 | 16868 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL124903 | 16868 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44315060 | 103112 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL307290 | 103112 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL938 | 218397 | None | 23 | Human | Binding | pIC50 | = | 8.9 | 8.9 | -1 | 2 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm00065a013 | |||||
| 15780089 | 99863 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 603 | 8 | 1 | 7 | 6.4 | Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL285432 | 99863 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 603 | 8 | 1 | 7 | 6.4 | Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 10349732 | 118817 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 695 | 13 | 2 | 9 | 7.1 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| CHEMBL341828 | 118817 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 695 | 13 | 2 | 9 | 7.1 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| 10101351 | 168767 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL436396 | 168767 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10259489 | 16925 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1021/jm00019a004 | |||
| CHEMBL125231 | 16925 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1021/jm00019a004 | |||
| 22850669 | 205444 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL63109 | 205444 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 10321941 | 138234 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 458 | 10 | 2 | 5 | 5.4 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1Cl | 10.1021/jm00108a043 | |||
| CHEMBL37679 | 138234 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 458 | 10 | 2 | 5 | 5.4 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1Cl | 10.1021/jm00108a043 | |||
| 20647138 | 100526 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 520 | 5 | 1 | 3 | 6.0 | O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL290829 | 100526 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 520 | 5 | 1 | 3 | 6.0 | O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 10033136 | 16080 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122380 | 16080 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10394859 | 17436 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL125760 | 17436 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 20647138 | 100526 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 520 | 5 | 1 | 3 | 6.0 | O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL290829 | 100526 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 520 | 5 | 1 | 3 | 6.0 | O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | |||
| 19430442 | 206633 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70726 | 206633 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 10078663 | 210246 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96075 | 210246 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | |||
| 10100951 | 115108 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL334300 | 115108 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| 10078663 | 210246 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| CHEMBL96075 | 210246 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| 44381553 | 120400 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 675 | 13 | 2 | 8 | 6.8 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352947 | 120400 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 675 | 13 | 2 | 8 | 6.8 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10100951 | 115108 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL334300 | 115108 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| 44315350 | 105274 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311484 | 105274 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 10417321 | 15625 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122157 | 15625 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44348523 | 113242 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL331450 | 113242 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 9870914 | 205785 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C(C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL64881 | 205785 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C(C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44299731 | 420 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | |||||
| 585 | 420 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | |||||
| CHEMBL56448 | 420 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | |||||
| 10395076 | 168679 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL435811 | 168679 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44315059 | 207170 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74144 | 207170 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 19430462 | 103039 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 735 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306638 | 103039 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 735 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44321824 | 208022 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 642 | 13 | 4 | 8 | 5.5 | CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL81236 | 208022 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 642 | 13 | 4 | 8 | 5.5 | CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 22402434 | 49041 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 551 | 9 | 1 | 5 | 5.8 | COc1ccc(COc2c(OC)ccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL156100 | 49041 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 551 | 9 | 1 | 5 | 5.8 | COc1ccc(COc2c(OC)ccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1016/S0960-894X(01)81122-7 | |||
| 44311617 | 102594 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 679 | 13 | 1 | 9 | 6.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL304065 | 102594 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 679 | 13 | 1 | 9 | 6.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311538 | 103018 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 699 | 14 | 1 | 10 | 6.9 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306435 | 103018 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 699 | 14 | 1 | 10 | 6.9 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311755 | 103189 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 735 | 18 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL307866 | 103189 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 735 | 18 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311071 | 103470 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 707 | 18 | 1 | 9 | 8.0 | CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL308482 | 103470 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 707 | 18 | 1 | 9 | 8.0 | CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311752 | 104921 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL311018 | 104921 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 10005139 | 57621 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 474 | 7 | 2 | 6 | 5.2 | CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC(C(=O)O)=C2 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1668008 | 57621 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 474 | 7 | 2 | 6 | 5.2 | CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC(C(=O)O)=C2 | 10.1016/j.bmc.2010.10.043 | |||
| 14403498 | 101085 | None | 3 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 495 | 7 | 1 | 5 | 4.4 | COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1021/jm00077a001 | |||
| CHEMBL294558 | 101085 | None | 3 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 495 | 7 | 1 | 5 | 4.4 | COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1021/jm00077a001 | |||
| 44303640 | 202569 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 511 | 12 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)cc1 | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL59611 | 202569 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 511 | 12 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)cc1 | 10.1016/S0960-894X(01)80554-0 | |||
| 44303208 | 205003 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 555 | 12 | 1 | 8 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(C)c1 | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL61168 | 205003 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 555 | 12 | 1 | 8 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(C)c1 | 10.1016/S0960-894X(01)80554-0 | |||
| 44210590 | 58731 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 605 | 11 | 3 | 8 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL168490 | 58731 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 605 | 11 | 3 | 8 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10078475 | 113393 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331632 | 113393 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 18965184 | 205374 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 504 | 4 | 0 | 2 | 7.3 | CC1CN(C(=O)N(c2ccccc2)c2ccccc2)C(C)CN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL62806 | 205374 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 504 | 4 | 0 | 2 | 7.3 | CC1CN(C(=O)N(c2ccccc2)c2ccccc2)C(C)CN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44330905 | 4411 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 746 | 19 | 1 | 8 | 8.2 | CCCCN(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)C(=O)c1ccccc1 | 10.1021/jm00015a016 | |||
| CHEMBL101455 | 4411 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 746 | 19 | 1 | 8 | 8.2 | CCCCN(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)C(=O)c1ccccc1 | 10.1021/jm00015a016 | |||
| 9937227 | 204629 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 543 | 12 | 1 | 7 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 | 10.1021/jm00015a016 | |||
| CHEMBL60942 | 204629 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 543 | 12 | 1 | 7 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 | 10.1021/jm00015a016 | |||
| 11755896 | 117036 | None | 0 | Rat | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 505 | 7 | 1 | 3 | 5.8 | COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1021/jm00077a001 | |||
| CHEMBL338709 | 117036 | None | 0 | Rat | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 505 | 7 | 1 | 3 | 5.8 | COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1021/jm00077a001 | |||
| 11765541 | 119072 | None | 0 | Rat | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL342605 | 119072 | None | 0 | Rat | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 9988057 | 106217 | None | 0 | Rat | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 831 | 10 | 5 | 15 | 3.3 | CC(=O)O[C@@H]1C2=C(C)[C@@H](OC(=O)[C@H](O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@]4(OC(C)=O)CO[C@@H]4C[C@H](O)[C@@]3(C)[C@H]1O)C2(C)C | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL313691 | 106217 | None | 0 | Rat | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 831 | 10 | 5 | 15 | 3.3 | CC(=O)O[C@@H]1C2=C(C)[C@@H](OC(=O)[C@H](O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@]4(OC(C)=O)CO[C@@H]4C[C@H](O)[C@@]3(C)[C@H]1O)C2(C)C | 10.1016/0960-894X(95)00477-B | |||
| 44311496 | 206702 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 722 | 15 | 2 | 8 | 7.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL71069 | 206702 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 722 | 15 | 2 | 8 | 7.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44379292 | 120398 | None | 0 | Rat | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 613 | 12 | 1 | 6 | 7.4 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL352934 | 120398 | None | 0 | Rat | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 613 | 12 | 1 | 6 | 7.4 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10077497 | 11373 | None | 0 | Rat | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1179757 | 11373 | None | 0 | Rat | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL98426 | 11373 | None | 0 | Rat | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 | 10.1021/jm00043a020 | |||
| 44328276 | 112790 | None | 0 | Rat | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 664 | 10 | 1 | 7 | 6.5 | C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330464 | 112790 | None | 0 | Rat | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 664 | 10 | 1 | 7 | 6.5 | C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| 10077929 | 209804 | None | 0 | Rat | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 643 | 14 | 2 | 8 | 5.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL93606 | 209804 | None | 0 | Rat | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 643 | 14 | 2 | 8 | 5.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1021/jm00043a020 | |||
| 15818748 | 99967 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 543 | 9 | 1 | 5 | 5.7 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL286134 | 99967 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 543 | 9 | 1 | 5 | 5.7 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44311571 | 206913 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL72249 | 206913 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44303248 | 205210 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 414 | 8 | 1 | 6 | 4.4 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1C | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL61976 | 205210 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 414 | 8 | 1 | 6 | 4.4 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1C | 10.1016/S0960-894X(01)80554-0 | |||
| 44311567 | 103068 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 607 | 11 | 2 | 8 | 6.4 | CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL306922 | 103068 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 607 | 11 | 2 | 8 | 6.4 | CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311450 | 104156 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 652 | 12 | 2 | 8 | 6.4 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL309365 | 104156 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 652 | 12 | 2 | 8 | 6.4 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311497 | 167960 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 547 | 10 | 1 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL430997 | 167960 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 547 | 10 | 1 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311664 | 206621 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 680 | 12 | 2 | 8 | 5.9 | CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70638 | 206621 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 680 | 12 | 2 | 8 | 5.9 | CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44377125 | 55655 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 545 | 10 | 1 | 7 | 5.0 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL162148 | 55655 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 545 | 10 | 1 | 7 | 5.0 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 1610 | 2347 | None | 64 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| 3941 | 2347 | None | 64 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| 3961 | 2347 | None | 64 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| 3961.0 | 2347 | None | 64 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| 590 | 2347 | None | 64 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL191 | 2347 | None | 64 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| DB00678 | 2347 | None | 64 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| 44376747 | 120153 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 510 | 11 | 2 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL350851 | 120153 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 510 | 11 | 2 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 9852384 | 100470 | None | 5 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm031031i | |||
| CHEMBL290214 | 100470 | None | 5 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm031031i | |||
| 9852384 | 100470 | None | 5 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm049715t | |||
| CHEMBL290214 | 100470 | None | 5 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm049715t | |||
| 9852384 | 100470 | None | 5 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | |||
| CHEMBL290214 | 100470 | None | 5 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | |||
| 23583071 | 188324 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 1450 | 7 | 8 | 31 | 4.6 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)N4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | |||
| CHEMBL499234 | 188324 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 1450 | 7 | 8 | 31 | 4.6 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)N4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | |||
| 164613196 | 185545 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 951 | 23 | 12 | 10 | 1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4861538 | 185545 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 951 | 23 | 12 | 10 | 1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1016/j.bmcl.2021.128086 | |||
| 10440203 | 119051 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 773 | 13 | 2 | 8 | 8.5 | CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL342492 | 119051 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 773 | 13 | 2 | 8 | 8.5 | CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44315058 | 70477 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL194608 | 70477 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44315344 | 105137 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311386 | 105137 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10258694 | 112650 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 648 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330165 | 112650 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 648 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 | 10.1021/jm00043a020 | |||
| 10233073 | 210092 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL95198 | 210092 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 | 10.1021/jm00043a020 | |||
| 10438523 | 210603 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 598 | 10 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL98126 | 210603 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 598 | 10 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | |||
| 57380412 | 70552 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1947129 | 70552 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 15296724 | 120082 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 462 | 7 | 2 | 5 | 4.3 | COc1ccc(NC(=O)N2Cc3ccc(OC)c(OCc4ccccc4)c3CC2C(=O)O)cc1 | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL350220 | 120082 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 462 | 7 | 2 | 5 | 4.3 | COc1ccc(NC(=O)N2Cc3ccc(OC)c(OCc4ccccc4)c3CC2C(=O)O)cc1 | 10.1016/S0960-894X(01)81122-7 | |||
| 11757357 | 210451 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 552 | 9 | 1 | 6 | 5.8 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97273 | 210451 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 552 | 9 | 1 | 6 | 5.8 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 23584461 | 178778 | None | 1 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 1368 | 7 | 9 | 30 | 4.9 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)O)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | |||
| CHEMBL467872 | 178778 | None | 1 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 1368 | 7 | 9 | 30 | 4.9 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)O)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | |||
| 90663955 | 106832 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 1280 | 38 | 16 | 17 | 0.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](NC[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)C(N)[C@H](CC(C)C)C(C)=O | 10.1021/jm00065a013 | |||
| CHEMBL3144487 | 106832 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 1280 | 38 | 16 | 17 | 0.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](NC[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)C(N)[C@H](CC(C)C)C(C)=O | 10.1021/jm00065a013 | |||
| 164625885 | 186372 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4873899 | 186372 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| 44303458 | 167985 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 559 | 12 | 1 | 7 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(Cl)c1 | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL431137 | 167985 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 559 | 12 | 1 | 7 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(Cl)c1 | 10.1016/S0960-894X(01)80554-0 | |||
| 10417251 | 96958 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL265797 | 96958 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 19939453 | 112454 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 686 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL329679 | 112454 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 686 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10417251 | 96958 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL265797 | 96958 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL413925 | 215562 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSS2 | 10.1021/jm00065a013 | |||||
| 44381724 | 120372 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 651 | 11 | 3 | 7 | 6.1 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352771 | 120372 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 651 | 11 | 3 | 7 | 6.1 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10259265 | 110099 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL323506 | 110099 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 44315180 | 102951 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL305956 | 102951 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44373238 | 97140 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 1051 | 29 | 11 | 12 | 1.9 | CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O | 10.1021/jm9504722 | |||
| CHEMBL267354 | 97140 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 1051 | 29 | 11 | 12 | 1.9 | CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O | 10.1021/jm9504722 | |||
| 44304147 | 100830 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 522 | 11 | 0 | 4 | 5.9 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL292939 | 100830 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 522 | 11 | 0 | 4 | 5.9 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44315057 | 207287 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL75401 | 207287 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44322236 | 112891 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 636 | 14 | 4 | 8 | 5.4 | CCCCc1nc(SC)c(C(O)CC(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL330744 | 112891 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 636 | 14 | 4 | 8 | 5.4 | CCCCc1nc(SC)c(C(O)CC(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 44323447 | 106957 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 627 | 11 | 1 | 9 | 6.5 | CCCCc1nc2ccn(C(C(=O)OC3CCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL314605 | 106957 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 627 | 11 | 1 | 9 | 6.5 | CCCCc1nc2ccn(C(C(=O)OC3CCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 44379269 | 57184 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 644 | 12 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL164769 | 57184 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 644 | 12 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10438745 | 107272 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 612 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316655 | 107272 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 612 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 | 10.1021/jm00043a020 | |||
| 10349597 | 111681 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 680 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL328434 | 111681 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 680 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 | 10.1021/jm00043a020 | |||
| 10416475 | 210163 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL95579 | 210163 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 | 10.1021/jm00043a020 | |||
| 44300735 | 100814 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 629 | 9 | 1 | 9 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL292829 | 100814 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 629 | 9 | 1 | 9 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 46910582 | 70377 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945009 | 70377 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 19385652 | 47532 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 459 | 9 | 1 | 6 | 5.3 | CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15458 | 47532 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 459 | 9 | 1 | 6 | 5.3 | CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 19385680 | 98935 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 487 | 10 | 1 | 6 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL279103 | 98935 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 487 | 10 | 1 | 6 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC | 10.1016/0960-894X(95)00185-V | |||
| 15696755 | 148111 | None | 0 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 306 | 7 | 1 | 3 | 3.6 | CCCCc1ncc(CC(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | |||
| CHEMBL39345 | 148111 | None | 0 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 306 | 7 | 1 | 3 | 3.6 | CCCCc1ncc(CC(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | |||
| 44323530 | 209638 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 586 | 10 | 1 | 8 | 5.1 | CCCCc1nc2ccn(C(C(=O)N(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL92479 | 209638 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 586 | 10 | 1 | 8 | 5.1 | CCCCc1nc2ccn(C(C(=O)N(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 10259395 | 27003 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 733 | 11 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL136465 | 27003 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 733 | 11 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44381552 | 120351 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 649 | 13 | 3 | 9 | 5.0 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352629 | 120351 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 649 | 13 | 3 | 9 | 5.0 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10349659 | 111606 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 688 | 10 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327988 | 111606 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 688 | 10 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 | 10.1021/jm00043a020 | |||
| 10439275 | 168163 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 654 | 10 | 1 | 7 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL432392 | 168163 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 654 | 10 | 1 | 7 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10054753 | 210605 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 629 | 9 | 2 | 7 | 5.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL98140 | 210605 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 629 | 9 | 2 | 7 | 5.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 44300615 | 199239 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 572 | 9 | 1 | 7 | 6.5 | CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL56549 | 199239 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 572 | 9 | 1 | 7 | 6.5 | CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| 44373417 | 52399 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 | 10.1021/jm9504722 | |||
| CHEMBL159004 | 52399 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 | 10.1021/jm9504722 | |||
| 57380649 | 70399 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 549 | 10 | 2 | 4 | 6.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945149 | 70399 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 549 | 10 | 2 | 4 | 6.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 11765394 | 118841 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 713 | 14 | 2 | 8 | 7.3 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C | 10.1021/jm00052a006 | |||
| CHEMBL341986 | 118841 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 713 | 14 | 2 | 8 | 7.3 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C | 10.1021/jm00052a006 | |||
| 19939409 | 107216 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 710 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL316299 | 107216 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 710 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 136026557 | 209320 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 617 | 11 | 1 | 10 | 6.6 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL90663 | 209320 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 617 | 11 | 1 | 10 | 6.6 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 44309903 | 206852 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL71925 | 206852 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 19939495 | 210284 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96314 | 210284 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 44309903 | 206852 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL71925 | 206852 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 44270330 | 51761 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 471 | 10 | 1 | 5 | 6.2 | CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15847 | 51761 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 471 | 10 | 1 | 5 | 6.2 | CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 57380647 | 70378 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945010 | 70378 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 10349791 | 111642 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL328176 | 111642 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 | 10.1021/jm00043a020 | |||
| 10008962 | 119337 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 615 | 10 | 2 | 8 | 5.4 | CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL343719 | 119337 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 615 | 10 | 2 | 8 | 5.4 | CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 73347893 | 92679 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435828 | 92679 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 10484866 | 31793 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 699 | 14 | 2 | 8 | 7.0 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| CHEMBL140619 | 31793 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 699 | 14 | 2 | 8 | 7.0 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| 44322097 | 107162 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 608 | 12 | 4 | 8 | 4.6 | CCCc1nc(SC)c(C(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL315994 | 107162 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 608 | 12 | 4 | 8 | 4.6 | CCCc1nc(SC)c(C(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 44381425 | 120518 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 681 | 12 | 3 | 8 | 7.2 | CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL353980 | 120518 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 681 | 12 | 3 | 8 | 7.2 | CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 18965154 | 100654 | None | 1 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 490 | 4 | 0 | 2 | 6.9 | CC1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL291818 | 100654 | None | 1 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 490 | 4 | 0 | 2 | 6.9 | CC1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44303880 | 205431 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 508 | 12 | 1 | 3 | 6.1 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CCO)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL63046 | 205431 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 508 | 12 | 1 | 3 | 6.1 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CCO)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44304044 | 205644 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 452 | 7 | 1 | 3 | 4.3 | CCCCCN(C)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL64280 | 205644 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 452 | 7 | 1 | 3 | 4.3 | CCCCCN(C)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44323293 | 107089 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 629 | 14 | 1 | 9 | 6.8 | CCCCCOC(=O)C(c1ccccc1)n1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1=O | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL315483 | 107089 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 629 | 14 | 1 | 9 | 6.8 | CCCCCOC(=O)C(c1ccccc1)n1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1=O | 10.1016/0960-894X(95)00477-B | |||
| 44323357 | 112450 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 648 | 11 | 1 | 8 | 6.7 | CCCCc1nc2ccn(C(C(=O)N(C)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL329655 | 112450 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 648 | 11 | 1 | 8 | 6.7 | CCCCc1nc2ccn(C(C(=O)N(C)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 44323352 | 209008 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 573 | 9 | 1 | 9 | 5.2 | CCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL88663 | 209008 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 573 | 9 | 1 | 9 | 5.2 | CCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 10326775 | 112302 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329089 | 112302 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 | 10.1021/jm00043a020 | |||
| 10483726 | 210035 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 600 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94910 | 210035 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 600 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10349506 | 210518 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97615 | 210518 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 | 10.1021/jm00043a020 | |||
| 44300637 | 100979 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 600 | 11 | 1 | 7 | 7.2 | CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL293949 | 100979 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 600 | 11 | 1 | 7 | 7.2 | CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| 10100413 | 201046 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 620 | 9 | 1 | 7 | 7.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL57853 | 201046 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 620 | 9 | 1 | 7 | 7.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 15296725 | 165380 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 535 | 9 | 0 | 5 | 5.9 | CCOC(=O)C1Cc2c(ccc(OC)c2OCc2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL423236 | 165380 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 535 | 9 | 0 | 5 | 5.9 | CCOC(=O)C1Cc2c(ccc(OC)c2OCc2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | |||
| 46910583 | 70376 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 561 | 11 | 2 | 5 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945008 | 70376 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 561 | 11 | 2 | 5 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 44379348 | 165016 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 558 | 10 | 1 | 7 | 4.7 | CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL422374 | 165016 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 558 | 10 | 1 | 7 | 4.7 | CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10439172 | 209942 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 644 | 13 | 2 | 8 | 5.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94355 | 209942 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 644 | 13 | 2 | 8 | 5.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 | 10.1021/jm00043a020 | |||
| 44377171 | 120275 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 485 | 6 | 1 | 8 | 5.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 | 10.1016/S0960-894X(01)80193-1 | |||
| CHEMBL352042 | 120275 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 485 | 6 | 1 | 8 | 5.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 | 10.1016/S0960-894X(01)80193-1 | |||
| 15287894 | 54963 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL16148 | 54963 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 44381739 | 58802 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL168771 | 58802 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44381739 | 58802 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL168771 | 58802 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| 10326797 | 210033 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 640 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94905 | 210033 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 640 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 | 10.1021/jm00043a020 | |||
| 10326460 | 210566 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 614 | 9 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97897 | 210566 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 614 | 9 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 44327912 | 210594 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 748 | 12 | 1 | 9 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC | 10.1021/jm00043a020 | |||
| CHEMBL98068 | 210594 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 748 | 12 | 1 | 9 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC | 10.1021/jm00043a020 | |||
| 44348153 | 118034 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 | 10.1021/jm00075a033 | |||
| CHEMBL340367 | 118034 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 | 10.1021/jm00075a033 | |||
| 44210836 | 56525 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 453 | 6 | 1 | 8 | 3.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 | 10.1016/S0960-894X(01)80193-1 | |||
| CHEMBL163523 | 56525 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 453 | 6 | 1 | 8 | 3.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 | 10.1016/S0960-894X(01)80193-1 | |||
| 73357017 | 92682 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 483 | 10 | 2 | 4 | 6.2 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435831 | 92682 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 483 | 10 | 2 | 4 | 6.2 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| 44323532 | 209592 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 635 | 11 | 1 | 9 | 6.6 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccc(Cl)cc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL92206 | 209592 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 635 | 11 | 1 | 9 | 6.6 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccc(Cl)cc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 9830680 | 100697 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL292150 | 100697 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 9830680 | 100697 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL292150 | 100697 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| 10372497 | 118810 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 692 | 11 | 1 | 9 | 6.3 | CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL341783 | 118810 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 692 | 11 | 1 | 9 | 6.3 | CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 9830680 | 100697 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL292150 | 100697 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10078800 | 109247 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL321531 | 109247 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 9830680 | 100697 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm9504722 | |||
| CHEMBL292150 | 100697 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm9504722 | |||
| 19754050 | 206338 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 603 | 15 | 2 | 7 | 6.6 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL68786 | 206338 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 603 | 15 | 2 | 7 | 6.6 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 44381528 | 59010 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 548 | 10 | 2 | 8 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169009 | 59010 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 548 | 10 | 2 | 8 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10394995 | 111457 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 702 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327191 | 111457 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 702 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 | 10.1021/jm00043a020 | |||
| 10077743 | 210416 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 630 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97068 | 210416 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 630 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1021/jm00043a020 | |||
| 44304148 | 205747 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 458 | 4 | 1 | 3 | 4.3 | CN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL64714 | 205747 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 458 | 4 | 1 | 3 | 4.3 | CN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | |||
| 22402428 | 48765 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 450 | 6 | 2 | 4 | 4.5 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Nc1ccc(F)cc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL155847 | 48765 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 450 | 6 | 2 | 4 | 4.5 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Nc1ccc(F)cc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| 15229605 | 48168 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 463 | 7 | 1 | 5 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15517 | 48168 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 463 | 7 | 1 | 5 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| 44323448 | 96903 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 559 | 10 | 2 | 8 | 5.1 | CCCCc1nc2ccn(C(C(=O)O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL265291 | 96903 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 559 | 10 | 2 | 8 | 5.1 | CCCCc1nc2ccn(C(C(=O)O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 11764788 | 100912 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL293501 | 100912 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 9810305 | 98625 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL276674 | 98625 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| 9895212 | 119704 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 614 | 9 | 1 | 6 | 7.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL346728 | 119704 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 614 | 9 | 1 | 6 | 7.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| 44385182 | 61094 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 637 | 10 | 3 | 7 | 5.7 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL176473 | 61094 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 637 | 10 | 3 | 7 | 5.7 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| 10031920 | 108043 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 628 | 10 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL319404 | 108043 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 628 | 10 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 | 10.1021/jm00043a020 | |||
| 44372814 | 119854 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 672 | 11 | 2 | 6 | 6.7 | CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1021/jm9504722 | |||
| CHEMBL348157 | 119854 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 672 | 11 | 2 | 6 | 6.7 | CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1021/jm9504722 | |||
| 44303888 | 205737 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 552 | 12 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL64674 | 205737 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 552 | 12 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 10390872 | 116210 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 490 | 7 | 1 | 6 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL335778 | 116210 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 490 | 7 | 1 | 6 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00050a002 | |||
| 44377086 | 120015 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 546 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349652 | 120015 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 546 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10101582 | 119440 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 747 | 15 | 2 | 8 | 7.4 | CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 | 10.1021/jm00052a006 | |||
| CHEMBL344466 | 119440 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 747 | 15 | 2 | 8 | 7.4 | CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 | 10.1021/jm00052a006 | |||
| 5311348 | 100727 | None | 1 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 480 | 6 | 2 | 5 | 4.0 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL292277 | 100727 | None | 1 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 480 | 6 | 2 | 5 | 4.0 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N | 10.1016/S0960-894X(01)81007-6 | |||
| 10484986 | 118761 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 713 | 11 | 1 | 9 | 6.8 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL341715 | 118761 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 713 | 11 | 1 | 9 | 6.8 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 1952 | 2209 | None | 2 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 2 | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F | 10.1021/jm00043a020 | |||
| 5312129 | 2209 | None | 2 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 2 | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F | 10.1021/jm00043a020 | |||
| CHEMBL1182768 | 2209 | None | 2 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 2 | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F | 10.1021/jm00043a020 | |||
| 9960852 | 107238 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 630 | 12 | 1 | 8 | 6.3 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316482 | 107238 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 630 | 12 | 1 | 8 | 6.3 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| 10416957 | 111562 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 662 | 10 | 1 | 7 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327791 | 111562 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 662 | 10 | 1 | 7 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 | 10.1021/jm00043a020 | |||
| 10010125 | 210490 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 724 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97464 | 210490 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 724 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 136059719 | 189238 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 1438 | 10 | 9 | 31 | 4.5 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | |||
| CHEMBL510526 | 189238 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 1438 | 10 | 9 | 31 | 4.5 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | |||
| 44300827 | 101822 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 602 | 8 | 1 | 7 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL299897 | 101822 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 602 | 8 | 1 | 7 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 44348355 | 113450 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 | 10.1021/jm00075a033 | |||
| CHEMBL331797 | 113450 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 | 10.1021/jm00075a033 | |||
| 44311289 | 102280 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 707 | 18 | 1 | 9 | 7.7 | CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL302964 | 102280 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 707 | 18 | 1 | 9 | 7.7 | CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311455 | 102799 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 782 | 17 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL305017 | 102799 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 782 | 17 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311754 | 103052 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 757 | 16 | 1 | 9 | 9.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306761 | 103052 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 757 | 16 | 1 | 9 | 9.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311715 | 103251 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 741 | 17 | 1 | 10 | 6.7 | CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL308323 | 103251 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 741 | 17 | 1 | 10 | 6.7 | CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311435 | 206480 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 693 | 17 | 1 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL69721 | 206480 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 693 | 17 | 1 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311434 | 206582 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 707 | 18 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70370 | 206582 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 707 | 18 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311414 | 206681 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 677 | 15 | 1 | 9 | 6.8 | CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70935 | 206681 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 677 | 15 | 1 | 9 | 6.8 | CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311413 | 206809 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 709 | 17 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71639 | 206809 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 709 | 17 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311753 | 207069 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 773 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL73283 | 207069 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 773 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 3936 | 2210 | None | 32 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116804 | |||
| 6603900 | 2210 | None | 32 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL288174 | 2210 | None | 32 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116804 | |||
| 44303191 | 167989 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 529 | 12 | 1 | 7 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(F)c1 | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL431162 | 167989 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 529 | 12 | 1 | 7 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(F)c1 | 10.1016/S0960-894X(01)80554-0 | |||
| 3936 | 2210 | None | 32 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm049715t | |||
| 6603900 | 2210 | None | 32 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm049715t | |||
| CHEMBL288174 | 2210 | None | 32 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm049715t | |||
| 3936 | 2210 | None | 32 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2010.03.064 | |||
| 6603900 | 2210 | None | 32 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2010.03.064 | |||
| CHEMBL288174 | 2210 | None | 32 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2010.03.064 | |||
| 44322095 | 107066 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 636 | 13 | 4 | 8 | 5.1 | CCCc1nc(SC)c(C(O)(CC)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL315327 | 107066 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 636 | 13 | 4 | 8 | 5.1 | CCCc1nc(SC)c(C(O)(CC)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 10259841 | 16165 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122401 | 16165 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10259447 | 16935 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL125280 | 16935 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | |||
| 11765177 | 117072 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338888 | 117072 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 3936 | 2210 | None | 32 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm9504722 | |||
| 6603900 | 2210 | None | 32 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm9504722 | |||
| CHEMBL288174 | 2210 | None | 32 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm9504722 | |||
| 44372744 | 52167 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 451 | 7 | 1 | 6 | 5.5 | CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 | 10.1021/jm9504722 | |||
| CHEMBL158795 | 52167 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 451 | 7 | 1 | 6 | 5.5 | CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 | 10.1021/jm9504722 | |||
| 3936 | 2210 | None | 32 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm031031i | |||
| 6603900 | 2210 | None | 32 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm031031i | |||
| CHEMBL288174 | 2210 | None | 32 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm031031i | |||
| 19430458 | 206532 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 769 | 16 | 1 | 9 | 8.4 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70100 | 206532 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 769 | 16 | 1 | 9 | 8.4 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 10010234 | 98480 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL275552 | 98480 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10078320 | 208973 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 684 | 13 | 4 | 8 | 5.8 | CCCc1nc(SC)c(C(O)(C(=O)O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL88446 | 208973 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 684 | 13 | 4 | 8 | 5.8 | CCCc1nc(SC)c(C(O)(C(=O)O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 44381426 | 120336 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 666 | 12 | 2 | 8 | 6.8 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352502 | 120336 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 666 | 12 | 2 | 8 | 6.8 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10349897 | 114492 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL333224 | 114492 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10259489 | 16925 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1021/jm00019a004 | |||
| CHEMBL125231 | 16925 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1021/jm00019a004 | |||
| 10078780 | 116980 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338433 | 116980 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10259468 | 118545 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL341369 | 118545 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44309938 | 206758 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 619 | 14 | 2 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL71388 | 206758 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 619 | 14 | 2 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 19802473 | 201161 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 415 | 5 | 1 | 7 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL58156 | 201161 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 415 | 5 | 1 | 7 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 10439862 | 118836 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 719 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL341934 | 118836 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 719 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10010195 | 119248 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 733 | 13 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL343142 | 119248 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 733 | 13 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10032851 | 16842 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL124771 | 16842 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10485116 | 116917 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| CHEMBL338101 | 116917 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| 9895984 | 207207 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL74476 | 207207 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10485116 | 116917 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338101 | 116917 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10372810 | 106258 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL313868 | 106258 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 44315180 | 102951 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL305956 | 102951 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9895984 | 207207 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74476 | 207207 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| 9892451 | 48754 | None | 24 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL155836 | 48754 | None | 24 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| 9895984 | 207207 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1021/jm9504722 | |||
| CHEMBL74476 | 207207 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1021/jm9504722 | |||
| 10101284 | 209861 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL93907 | 209861 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 10101284 | 209861 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL93907 | 209861 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 16133225 | 419 | None | 38 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | |||||
| 172198 | 419 | None | 38 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | |||||
| 172198.0 | 419 | None | 38 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | |||||
| 2504 | 419 | None | 38 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | |||||
| 45266664 | 419 | None | 38 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | |||||
| 5272 | 419 | None | 38 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | |||||
| CHEMBL408403 | 419 | None | 38 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | |||||
| DB11842 | 419 | None | 38 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | |||||
| 11765560 | 15544 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL121872 | 15544 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10010071 | 117413 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339722 | 117413 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10101284 | 209861 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL93907 | 209861 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00019a004 | |||
| 44315060 | 103112 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL307290 | 103112 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 10032877 | 15556 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL121907 | 15556 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10462683 | 113345 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331507 | 113345 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10417195 | 109135 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL321313 | 109135 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 44310069 | 206196 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 617 | 16 | 2 | 7 | 7.0 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL67801 | 206196 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 617 | 16 | 2 | 7 | 7.0 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 10009984 | 113243 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331455 | 113243 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44303884 | 205291 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL62422 | 205291 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44381403 | 59184 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 675 | 11 | 2 | 9 | 5.4 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169968 | 59184 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 675 | 11 | 2 | 9 | 5.4 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10259657 | 119457 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 781 | 14 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL344597 | 119457 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 781 | 14 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44381413 | 120786 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 661 | 14 | 3 | 8 | 6.6 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL354779 | 120786 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 661 | 14 | 3 | 8 | 6.6 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 9987414 | 117113 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339113 | 117113 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44311453 | 206495 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 678 | 17 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL69839 | 206495 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 678 | 17 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311557 | 206741 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71286 | 206741 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311558 | 207180 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL74236 | 207180 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44303388 | 163002 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 539 | 12 | 1 | 7 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(C)c1 | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL417393 | 163002 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 539 | 12 | 1 | 7 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(C)c1 | 10.1016/S0960-894X(01)80554-0 | |||
| 44303459 | 202743 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 586 | 13 | 1 | 10 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL59728 | 202743 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 586 | 13 | 1 | 10 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)80554-0 | |||
| 44303197 | 204693 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 619 | 12 | 1 | 8 | 5.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Br)c1 | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL60992 | 204693 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 619 | 12 | 1 | 8 | 5.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Br)c1 | 10.1016/S0960-894X(01)80554-0 | |||
| 10394727 | 103117 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 672 | 15 | 2 | 9 | 5.4 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL307321 | 103117 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 672 | 15 | 2 | 9 | 5.4 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44210589 | 58613 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 619 | 11 | 3 | 8 | 5.4 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL168413 | 58613 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 619 | 11 | 3 | 8 | 5.4 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 11765454 | 118132 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL340473 | 118132 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10092454 | 100301 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 401 | 7 | 2 | 5 | 4.9 | CCCCc1nc2ccnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00037a014 | |||
| CHEMBL288705 | 100301 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 401 | 7 | 2 | 5 | 4.9 | CCCCc1nc2ccnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00037a014 | |||
| 44303859 | 203448 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 514 | 8 | 1 | 3 | 5.8 | CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL60209 | 203448 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 514 | 8 | 1 | 3 | 5.8 | CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | |||
| 9896877 | 60252 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 748 | 6 | 1 | 8 | 8.3 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL174080 | 60252 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 748 | 6 | 1 | 8 | 8.3 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | |||
| 44311584 | 102835 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 695 | 16 | 1 | 8 | 8.1 | CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL305239 | 102835 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 695 | 16 | 1 | 8 | 8.1 | CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311406 | 103862 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL309081 | 103862 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 10480819 | 21813 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 492 | 6 | 1 | 3 | 6.1 | COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(c2ccccc2)c2ccccc2)C3)cc1 | 10.1021/jm00077a001 | |||
| CHEMBL131940 | 21813 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 492 | 6 | 1 | 3 | 6.1 | COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(c2ccccc2)c2ccccc2)C3)cc1 | 10.1021/jm00077a001 | |||
| 44311635 | 102279 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 581 | 10 | 2 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL302959 | 102279 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 581 | 10 | 2 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F | 10.1016/S0960-894X(00)80076-1 | |||
| 44311499 | 206857 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 557 | 17 | 2 | 7 | 6.6 | CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL71953 | 206857 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 557 | 17 | 2 | 7 | 6.6 | CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | |||
| 44384389 | 129905 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 572 | 2 | 2 | 7 | 5.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL367569 | 129905 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 572 | 2 | 2 | 7 | 5.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 | 10.1016/0960-894X(96)00116-3 | |||
| 10429298 | 18909 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 371 | 4 | 1 | 2 | 3.9 | O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL128416 | 18909 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 371 | 4 | 1 | 2 | 3.9 | O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | |||
| 44210864 | 148193 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 503 | 8 | 1 | 5 | 4.8 | CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL39352 | 148193 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 503 | 8 | 1 | 5 | 4.8 | CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 9850811 | 154830 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 561 | 8 | 1 | 6 | 5.3 | CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL39996 | 154830 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 561 | 8 | 1 | 6 | 5.3 | CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44311616 | 102195 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL302485 | 102195 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311776 | 103070 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306924 | 103070 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 10255071 | 163559 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 491 | 6 | 0 | 4 | 5.6 | COC(=O)C1Cc2c(cccc2-c2ccc(OC)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| CHEMBL419974 | 163559 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 491 | 6 | 0 | 4 | 5.6 | COC(=O)C1Cc2c(cccc2-c2ccc(OC)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| 9981762 | 163561 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 461 | 5 | 0 | 3 | 5.6 | COC(=O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| CHEMBL419979 | 163561 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 461 | 5 | 0 | 3 | 5.6 | COC(=O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| 44379347 | 120551 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 544 | 9 | 1 | 7 | 4.3 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL354338 | 120551 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 544 | 9 | 1 | 7 | 4.3 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44377075 | 120041 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 479 | 10 | 1 | 6 | 4.1 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349869 | 120041 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 479 | 10 | 1 | 6 | 4.1 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 15287882 | 49757 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 414 | 9 | 1 | 4 | 5.6 | CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15670 | 49757 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 414 | 9 | 1 | 4 | 5.6 | CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 22407453 | 49772 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 415 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15671 | 49772 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 415 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 9987311 | 116821 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 706 | 12 | 1 | 9 | 6.7 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL337588 | 116821 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 706 | 12 | 1 | 9 | 6.7 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 14952914 | 155000 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 410 | 9 | 2 | 5 | 5.1 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(O)c(C)c1 | 10.1021/jm00108a043 | |||
| CHEMBL40089 | 155000 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 410 | 9 | 2 | 5 | 5.1 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(O)c(C)c1 | 10.1021/jm00108a043 | |||
| 44338666 | 111021 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 551 | 9 | 1 | 8 | 5.5 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL326217 | 111021 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 551 | 9 | 1 | 8 | 5.5 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 44379335 | 120285 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 574 | 10 | 2 | 6 | 6.0 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL352137 | 120285 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 574 | 10 | 2 | 6 | 6.0 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44379293 | 120354 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 611 | 10 | 1 | 6 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL352639 | 120354 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 611 | 10 | 1 | 6 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44376780 | 56520 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 509 | 10 | 1 | 7 | 4.1 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL163486 | 56520 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 509 | 10 | 1 | 7 | 4.1 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 44300734 | 101861 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 586 | 9 | 1 | 7 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL300154 | 101861 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 586 | 9 | 1 | 7 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 10049400 | 155530 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL40381 | 155530 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 44323358 | 112568 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 626 | 10 | 1 | 8 | 6.0 | CCCCc1nc2ccn(C(C(=O)N3CCCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL329887 | 112568 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 626 | 10 | 1 | 8 | 6.0 | CCCCc1nc2ccn(C(C(=O)N3CCCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 19939398 | 107390 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 626 | 10 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL317547 | 107390 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 626 | 10 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10055534 | 157553 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL407919 | 157553 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 44338833 | 9181 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 537 | 9 | 2 | 8 | 5.4 | CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL110265 | 9181 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 537 | 9 | 2 | 8 | 5.4 | CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 15231091 | 94041 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL24861 | 94041 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 15231091 | 94041 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL24861 | 94041 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL443325 | 216382 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSSC[C@H](C(=O)N[C@H](Cc1c[nH]cn1)C(=O)N1CCC[C@@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H]1C[C@H](CN1C(=O)[C@@H](CCCN=C(N)N)NC(=O)CNC)SS2 | 10.1021/jm00065a013 | |||||
| 44303857 | 100864 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL293195 | 100864 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O | 10.1016/S0960-894X(01)81007-6 | |||
| 10417144 | 32988 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 679 | 11 | 1 | 9 | 6.4 | CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL141592 | 32988 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 679 | 11 | 1 | 9 | 6.4 | CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44303852 | 102404 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 524 | 11 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL303755 | 102404 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 524 | 11 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 18950586 | 15571 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 | 10.1021/jm00075a033 | |||
| CHEMBL122017 | 15571 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 | 10.1021/jm00075a033 | |||
| 44377058 | 120070 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 554 | 16 | 3 | 6 | 5.8 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL350121 | 120070 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 554 | 16 | 3 | 6 | 5.8 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10482937 | 167233 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL321086 | 167233 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL429058 | 167233 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 14956757 | 67614 | None | 0 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL19018 | 67614 | None | 0 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00052a006 | |||
| 14956757 | 67614 | None | 0 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL19018 | 67614 | None | 0 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00043a020 | |||
| 4189 | 209380 | None | 58 | Human | Binding | pIC50 | = | 4.6 | 4.6 | -38 | 34 | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | |||
| CHEMBL1559 | 209380 | None | 58 | Human | Binding | pIC50 | = | 4.6 | 4.6 | -38 | 34 | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | |||
| CHEMBL91 | 209380 | None | 58 | Human | Binding | pIC50 | = | 4.6 | 4.6 | -38 | 34 | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | |||
| 71455883 | 83797 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 495 | 6 | 2 | 7 | 4.7 | O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O | 10.1016/j.ejmech.2020.112872 | |||
| CHEMBL2205685 | 83797 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 495 | 6 | 2 | 7 | 4.7 | O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O | 10.1016/j.ejmech.2020.112872 | |||
| 44372686 | 96708 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 600 | 4 | 2 | 7 | 6.2 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O | 10.1021/jm9504722 | |||
| CHEMBL263714 | 96708 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 600 | 4 | 2 | 7 | 6.2 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O | 10.1021/jm9504722 | |||
| 44211677 | 130682 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 614 | 4 | 2 | 7 | 6.6 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL368149 | 130682 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 614 | 4 | 2 | 7 | 6.6 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | |||
| 164623569 | 186293 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 1008 | 26 | 12 | 10 | 2.6 | CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)[C@@H](C)CC)C1=O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4872735 | 186293 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 1008 | 26 | 12 | 10 | 2.6 | CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)[C@@H](C)CC)C1=O | 10.1016/j.bmcl.2021.128086 | |||
| 44348302 | 16498 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm00075a033 | |||
| CHEMBL123562 | 16498 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm00075a033 | |||
| 11764826 | 98337 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 648 | 11 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL274710 | 98337 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 648 | 11 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 44348302 | 16498 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm9504722 | |||
| CHEMBL123562 | 16498 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm9504722 | |||
| 10028460 | 116585 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 488 | 7 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL336180 | 116585 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 488 | 7 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00050a002 | |||
| 10349512 | 210466 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 670 | 11 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97332 | 210466 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 670 | 11 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 19385665 | 51076 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 471 | 9 | 1 | 5 | 6.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15788 | 51076 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 471 | 9 | 1 | 5 | 6.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C | 10.1016/0960-894X(95)00185-V | |||
| 10028815 | 210554 | None | 0 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 496 | 8 | 1 | 6 | 4.4 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97783 | 210554 | None | 0 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 496 | 8 | 1 | 6 | 4.4 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL411657 | 215414 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSS[C@H]1C[C@@H](C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)CSS2)N(C(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C1 | 10.1021/jm00065a013 | |||||
| 10078397 | 12113 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 692 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1184032 | 12113 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 692 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329290 | 12113 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 692 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| 168298448 | 192812 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 477 | 5 | 2 | 4 | 5.8 | O=c1c(O)c(-c2ccccc2-c2ccc(CNc3cc(C(F)(F)F)cc4c3CCCC4)cc2)c1=O | 10.1016/j.ejmech.2020.112872 | |||
| CHEMBL5219534 | 192812 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 477 | 5 | 2 | 4 | 5.8 | O=c1c(O)c(-c2ccccc2-c2ccc(CNc3cc(C(F)(F)F)cc4c3CCCC4)cc2)c1=O | 10.1016/j.ejmech.2020.112872 | |||
| 44211576 | 107174 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 573 | 10 | 1 | 9 | 5.2 | CCCCc1nc2ccn(C(C(=O)OC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL316063 | 107174 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 573 | 10 | 1 | 9 | 5.2 | CCCCc1nc2ccn(C(C(=O)OC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 136059721 | 189106 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 1537 | 12 | 10 | 33 | 3.3 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | |||
| CHEMBL508699 | 189106 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 1537 | 12 | 10 | 33 | 3.3 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | |||
| 10429298 | 18909 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 371 | 4 | 1 | 2 | 3.9 | O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| CHEMBL128416 | 18909 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 371 | 4 | 1 | 2 | 3.9 | O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| 44300838 | 201126 | None | 0 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 530 | 7 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL57976 | 201126 | None | 0 | Rat | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 530 | 7 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 10009968 | 112610 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329942 | 112610 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 10372341 | 168301 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL433375 | 168301 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 | 10.1021/jm00043a020 | |||
| 16725318 | 189071 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 1494 | 11 | 9 | 32 | 4.6 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | |||
| CHEMBL508306 | 189071 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 1494 | 11 | 9 | 32 | 4.6 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | |||
| 192626 | 15666 | None | 9 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 499 | 11 | 1 | 5 | 6.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 | 10.1021/jm00075a033 | |||
| CHEMBL122212 | 15666 | None | 9 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 499 | 11 | 1 | 5 | 6.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 | 10.1021/jm00075a033 | |||
| 9978845 | 130780 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 408 | 9 | 1 | 3 | 5.6 | CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | |||
| CHEMBL36846 | 130780 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 408 | 9 | 1 | 3 | 5.6 | CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | |||
| CHEMBL417584 | 215695 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | None | None | None | NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00065a013 | |||||
| 9939191 | 99000 | None | 1 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL279629 | 99000 | None | 1 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL97539 | 99000 | None | 1 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 10326972 | 112324 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 654 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329099 | 112324 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 654 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 | 10.1021/jm00043a020 | |||
| 10077555 | 209869 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL93956 | 209869 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 | 10.1021/jm00043a020 | |||
| 19102815 | 210337 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96554 | 210337 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 19385603 | 98833 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 455 | 9 | 1 | 5 | 5.6 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL278234 | 98833 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 455 | 9 | 1 | 5 | 5.6 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL408885 | 215196 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | None | None | None | NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSCC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00065a013 | |||||
| 19754062 | 103040 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 604 | 13 | 3 | 7 | 5.9 | CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL306641 | 103040 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 604 | 13 | 3 | 7 | 5.9 | CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 10349029 | 210555 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 628 | 10 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97812 | 210555 | None | 0 | Rat | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 628 | 10 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 | 10.1021/jm00043a020 | |||
| 9888865 | 57514 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 429 | 6 | 1 | 6 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 | 10.1016/S0960-894X(01)80193-1 | |||
| CHEMBL165974 | 57514 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 429 | 6 | 1 | 6 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 | 10.1016/S0960-894X(01)80193-1 | |||
| 10055448 | 30771 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 691 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL139582 | 30771 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 691 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44379334 | 58128 | None | 1 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 585 | 10 | 2 | 9 | 4.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL167584 | 58128 | None | 1 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 585 | 10 | 2 | 9 | 4.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44381603 | 59133 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 532 | 8 | 2 | 7 | 3.8 | CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169798 | 59133 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 532 | 8 | 2 | 7 | 3.8 | CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 133031 | 100913 | None | 21 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL293511 | 100913 | None | 21 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 133031 | 100913 | None | 21 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL293511 | 100913 | None | 21 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00050a002 | |||
| 19385675 | 51389 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 445 | 8 | 1 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15816 | 51389 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 445 | 8 | 1 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | |||
| 44311537 | 102387 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 726 | 15 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL303647 | 102387 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 726 | 15 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311580 | 102834 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 706 | 16 | 2 | 9 | 6.9 | CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL305238 | 102834 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 706 | 16 | 2 | 9 | 6.9 | CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311182 | 103082 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL307008 | 103082 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311619 | 103125 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 756 | 16 | 2 | 8 | 8.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL307359 | 103125 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 756 | 16 | 2 | 8 | 8.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311185 | 104246 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 733 | 15 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL309790 | 104246 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 733 | 15 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311073 | 206658 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 746 | 16 | 1 | 10 | 6.6 | CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70843 | 206658 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 746 | 16 | 1 | 10 | 6.6 | CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311184 | 206879 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 727 | 16 | 1 | 9 | 8.6 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL72099 | 206879 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 727 | 16 | 1 | 9 | 8.6 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311183 | 207158 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL74069 | 207158 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311735 | 207210 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 753 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL74514 | 207210 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 753 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 9937227 | 204629 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 543 | 12 | 1 | 7 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL60942 | 204629 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 543 | 12 | 1 | 7 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 | 10.1016/S0960-894X(01)80554-0 | |||
| 9851082 | 101074 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| CHEMBL294512 | 101074 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| 9987283 | 162036 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 705 | 16 | 1 | 9 | 6.7 | CCCc1nc(CC)c(C(=O)CCN(C(C)=O)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| CHEMBL415502 | 162036 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 705 | 16 | 1 | 9 | 6.7 | CCCc1nc(CC)c(C(=O)CCN(C(C)=O)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| 133031 | 100913 | None | 21 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL293511 | 100913 | None | 21 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 9937227 | 204629 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 543 | 12 | 1 | 7 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 | 10.1021/jm9504722 | |||
| CHEMBL60942 | 204629 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 543 | 12 | 1 | 7 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 | 10.1021/jm9504722 | |||
| 10032820 | 117368 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339672 | 117368 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 10372659 | 118154 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL340632 | 118154 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44315351 | 104941 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311160 | 104941 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44381402 | 59183 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 647 | 12 | 2 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169967 | 59183 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 647 | 12 | 2 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 15780064 | 99677 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 613 | 10 | 1 | 8 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL284123 | 99677 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 613 | 10 | 1 | 8 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 44381671 | 120491 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 647 | 13 | 3 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL353800 | 120491 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 647 | 13 | 3 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 15292113 | 96086 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL259843 | 96086 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10032858 | 29769 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 729 | 12 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL138690 | 29769 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 729 | 12 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00052a006 | |||
| 9853391 | 116903 | None | 1 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338027 | 116903 | None | 1 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10439715 | 117099 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339040 | 117099 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10350123 | 57620 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 713 | 12 | 1 | 9 | 6.0 | CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1668007 | 57620 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 713 | 12 | 1 | 9 | 6.0 | CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F | 10.1016/j.bmc.2010.10.043 | |||
| 19939418 | 108326 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 733 | 13 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL319730 | 108326 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 733 | 13 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 19939495 | 210284 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96314 | 210284 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10395335 | 117146 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339256 | 117146 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 44315144 | 96645 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL263191 | 96645 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44381527 | 59091 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169568 | 59091 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44210588 | 120409 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 633 | 12 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL353037 | 120409 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 633 | 12 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10440144 | 116958 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338342 | 116958 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10462573 | 117073 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338889 | 117073 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44382947 | 59251 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 813 | 19 | 4 | 12 | 6.4 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)CCNc1ccc([N+](=O)[O-])c2nonc12 | 10.1016/S0960-894X(00)80690-3 | |||
| CHEMBL170290 | 59251 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 813 | 19 | 4 | 12 | 6.4 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)CCNc1ccc([N+](=O)[O-])c2nonc12 | 10.1016/S0960-894X(00)80690-3 | |||
| 10101608 | 117093 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL339004 | 117093 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10372451 | 117358 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339605 | 117358 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10010164 | 117461 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL339806 | 117461 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10101284 | 209861 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL93907 | 209861 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00019a004 | |||
| 9850834 | 154752 | None | 20 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL39959 | 154752 | None | 20 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 10032988 | 116981 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338434 | 116981 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44321825 | 107166 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 636 | 13 | 4 | 8 | 5.1 | CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL316021 | 107166 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 636 | 13 | 4 | 8 | 5.1 | CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 44309700 | 103240 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 651 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL308237 | 103240 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 651 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| 10433752 | 18928 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 447 | 5 | 1 | 2 | 5.5 | O=C(O)C1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| CHEMBL128527 | 18928 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 447 | 5 | 1 | 2 | 5.5 | O=C(O)C1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| 44283372 | 100474 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 447 | 5 | 1 | 2 | 5.5 | O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL290286 | 100474 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 447 | 5 | 1 | 2 | 5.5 | O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 9875044 | 210488 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97446 | 210488 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 44303835 | 101821 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 494 | 11 | 1 | 3 | 5.7 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL299887 | 101821 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 494 | 11 | 1 | 3 | 5.7 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44283372 | 100474 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 447 | 5 | 1 | 2 | 5.5 | O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm9504722 | |||
| CHEMBL290286 | 100474 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 447 | 5 | 1 | 2 | 5.5 | O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm9504722 | |||
| 44311609 | 102863 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL305369 | 102863 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311428 | 103024 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 647 | 17 | 1 | 8 | 7.1 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306473 | 103024 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 647 | 17 | 1 | 8 | 7.1 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311583 | 206578 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70353 | 206578 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 11740800 | 18844 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 385 | 4 | 1 | 2 | 4.2 | Cc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1021/jm00077a001 | |||
| CHEMBL128065 | 18844 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 385 | 4 | 1 | 2 | 4.2 | Cc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1021/jm00077a001 | |||
| 10386376 | 18944 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 402 | 4 | 1 | 3 | 4.5 | CN(C(=O)N1Cc2ccc(Oc3ccccc3)cc2CC1C(=O)O)c1ccccc1 | 10.1021/jm00077a001 | |||
| CHEMBL128594 | 18944 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 402 | 4 | 1 | 3 | 4.5 | CN(C(=O)N1Cc2ccc(Oc3ccccc3)cc2CC1C(=O)O)c1ccccc1 | 10.1021/jm00077a001 | |||
| 9939191 | 99000 | None | 1 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL279629 | 99000 | None | 1 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL97539 | 99000 | None | 1 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00052a006 | |||
| 44323387 | 106043 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 600 | 11 | 2 | 8 | 5.6 | CCCCc1nc2ccn(C(C(=O)NC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL313142 | 106043 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 600 | 11 | 2 | 8 | 5.6 | CCCCc1nc2ccn(C(C(=O)NC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 44323364 | 111963 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 599 | 10 | 1 | 8 | 6.6 | CCCCc1nc2ccn(C(C(=O)C(C)(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL328780 | 111963 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 599 | 10 | 1 | 8 | 6.6 | CCCCc1nc2ccn(C(C(=O)C(C)(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 44311758 | 207129 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 626 | 12 | 3 | 7 | 6.7 | CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL73780 | 207129 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 626 | 12 | 3 | 7 | 6.7 | CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 9939191 | 99000 | None | 1 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL279629 | 99000 | None | 1 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL97539 | 99000 | None | 1 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 44379350 | 120849 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 599 | 10 | 1 | 7 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL355443 | 120849 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 599 | 10 | 1 | 7 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 9939191 | 99000 | None | 1 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL279629 | 99000 | None | 1 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL97539 | 99000 | None | 1 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00019a004 | |||
| 9939191 | 99000 | None | 1 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL279629 | 99000 | None | 1 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97539 | 99000 | None | 1 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10348847 | 112652 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 615 | 10 | 2 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330170 | 112652 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 615 | 10 | 2 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10054912 | 210091 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL95197 | 210091 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 | 10.1021/jm00043a020 | |||
| 10054827 | 164233 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 634 | 11 | 1 | 8 | 6.8 | CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL42101 | 164233 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 634 | 11 | 1 | 8 | 6.8 | CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 19385729 | 50894 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 471 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15774 | 50894 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 471 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 | 10.1016/0960-894X(95)00185-V | |||
| 15818746 | 124136 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 529 | 8 | 1 | 5 | 5.3 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL36324 | 124136 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 529 | 8 | 1 | 5 | 5.3 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44311775 | 103069 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306923 | 103069 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44303636 | 169201 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 418 | 8 | 1 | 6 | 4.2 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL439936 | 169201 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 418 | 8 | 1 | 6 | 4.2 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F | 10.1016/S0960-894X(01)80554-0 | |||
| 44311681 | 103078 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 592 | 11 | 2 | 9 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL306961 | 103078 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 592 | 11 | 2 | 9 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44384870 | 60066 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 541 | 8 | 2 | 7 | 5.5 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL173643 | 60066 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 541 | 8 | 2 | 7 | 5.5 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| 44270285 | 99119 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 415 | 7 | 1 | 5 | 4.7 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL280456 | 99119 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 415 | 7 | 1 | 5 | 4.7 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 9980304 | 98589 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 433 | 9 | 3 | 8 | 1.4 | CCCCc1nc(C(N)=O)c(C(N)=O)n1Cc1ccc(-n2cccc2-c2nn[nH]n2)cc1 | 10.1021/jm00053a013 | |||
| CHEMBL276381 | 98589 | None | 0 | Rat | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 433 | 9 | 3 | 8 | 1.4 | CCCCc1nc(C(N)=O)c(C(N)=O)n1Cc1ccc(-n2cccc2-c2nn[nH]n2)cc1 | 10.1021/jm00053a013 | |||
| 10258916 | 29719 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 668 | 11 | 1 | 10 | 6.1 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL138654 | 29719 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 668 | 11 | 1 | 10 | 6.1 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| 14952906 | 100559 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 425 | 10 | 1 | 6 | 5.0 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1[N+](=O)[O-] | 10.1021/jm00108a043 | |||
| CHEMBL291086 | 100559 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 425 | 10 | 1 | 6 | 5.0 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1[N+](=O)[O-] | 10.1021/jm00108a043 | |||
| 11764788 | 100912 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm990504b | |||
| CHEMBL293501 | 100912 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm990504b | |||
| 10439253 | 112384 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329255 | 112384 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 | 10.1021/jm00043a020 | |||
| 164611280 | 185105 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4854474 | 185105 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| 10077328 | 208930 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 601 | 11 | 1 | 9 | 6.0 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL88170 | 208930 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 601 | 11 | 1 | 9 | 6.0 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 44315060 | 103112 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL307290 | 103112 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44404967 | 135489 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 680 | 12 | 1 | 8 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 | 10.1021/jm058225d | |||
| CHEMBL372814 | 135489 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 680 | 12 | 1 | 8 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 | 10.1021/jm058225d | |||
| 44323345 | 107060 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 557 | 10 | 1 | 8 | 5.6 | CCCCc1nc2ccn(C(C(C)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL315302 | 107060 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 557 | 10 | 1 | 8 | 5.6 | CCCCc1nc2ccn(C(C(C)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 10372723 | 107374 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 724 | 12 | 1 | 7 | 7.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL317368 | 107374 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 724 | 12 | 1 | 7 | 7.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 15231094 | 139384 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 641 | 12 | 1 | 8 | 7.4 | CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL37919 | 139384 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 641 | 12 | 1 | 8 | 7.4 | CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 44309719 | 206312 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 544 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL68638 | 206312 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 544 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 44323365 | 112138 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 619 | 11 | 1 | 8 | 6.9 | CCCCc1nc2ccn(C(C(=O)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL328997 | 112138 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 619 | 11 | 1 | 8 | 6.9 | CCCCc1nc2ccn(C(C(=O)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 44379270 | 56873 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 580 | 9 | 1 | 7 | 5.2 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL164395 | 56873 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 580 | 9 | 1 | 7 | 5.2 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10010027 | 210491 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 710 | 11 | 1 | 7 | 7.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97465 | 210491 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 710 | 11 | 1 | 7 | 7.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 130762 | 98300 | None | 4 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00053a013 | |||
| CHEMBL274447 | 98300 | None | 4 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00053a013 | |||
| 44270306 | 52193 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 457 | 8 | 1 | 5 | 6.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15882 | 52193 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 457 | 8 | 1 | 5 | 6.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 | 10.1016/0960-894X(95)00185-V | |||
| 5311345 | 3021 | None | 38 | Human | Binding | pIC50 | = | 7.5 | 7.5 | 10 | 2 | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/jm049715t | |||
| 597 | 3021 | None | 38 | Human | Binding | pIC50 | = | 7.5 | 7.5 | 10 | 2 | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/jm049715t | |||
| CHEMBL321820 | 3021 | None | 38 | Human | Binding | pIC50 | = | 7.5 | 7.5 | 10 | 2 | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/jm049715t | |||
| 10394712 | 119441 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 671 | 12 | 2 | 8 | 6.2 | CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL344467 | 119441 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 671 | 12 | 2 | 8 | 6.2 | CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 122189454 | 123323 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 497 | 7 | 1 | 5 | 4.1 | COc1ccc(CN2C=NC3CN(C(=O)C(c4ccccc4)c4ccccc4)C(C(=O)O)CC32)cc1C | 10.1016/j.bmc.2015.07.045 | |||
| CHEMBL3613974 | 123323 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 497 | 7 | 1 | 5 | 4.1 | COc1ccc(CN2C=NC3CN(C(=O)C(c4ccccc4)c4ccccc4)C(C(=O)O)CC32)cc1C | 10.1016/j.bmc.2015.07.045 | |||
| 5311345 | 3021 | None | 38 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 2 | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/jm9504722 | |||
| 597 | 3021 | None | 38 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 2 | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/jm9504722 | |||
| CHEMBL321820 | 3021 | None | 38 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 2 | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/jm9504722 | |||
| 44379217 | 58166 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 608 | 10 | 2 | 6 | 7.1 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL167929 | 58166 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 608 | 10 | 2 | 6 | 7.1 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 15287883 | 98263 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 415 | 8 | 1 | 5 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL274260 | 98263 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 415 | 8 | 1 | 5 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 10461785 | 11927 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 639 | 10 | 1 | 9 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1182712 | 11927 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 639 | 10 | 1 | 9 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL262296 | 11927 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 639 | 10 | 1 | 9 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 | 10.1021/jm00043a020 | |||
| 10032342 | 210481 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 662 | 10 | 1 | 9 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97394 | 210481 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 662 | 10 | 1 | 9 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 | 10.1021/jm00043a020 | |||
| 44303941 | 205713 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 580 | 13 | 1 | 5 | 6.0 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)OCC)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL64575 | 205713 | None | 0 | Rat | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 580 | 13 | 1 | 5 | 6.0 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)OCC)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 22402431 | 49114 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 575 | 8 | 1 | 4 | 6.8 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL156165 | 49114 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 575 | 8 | 1 | 4 | 6.8 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| 44384871 | 129388 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 726 | 14 | 1 | 7 | 8.0 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL367095 | 129388 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 726 | 14 | 1 | 7 | 8.0 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | |||
| 18950609 | 16412 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl | 10.1021/jm00075a033 | |||
| CHEMBL123084 | 16412 | None | 0 | Rat | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl | 10.1021/jm00075a033 | |||
| 44321626 | 106022 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 616 | 14 | 3 | 9 | 4.8 | CCCCc1nc(SC)c(C(C)(O)C(=O)OCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL313005 | 106022 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 616 | 14 | 3 | 9 | 4.8 | CCCCc1nc(SC)c(C(C)(O)C(=O)OCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 9809961 | 107217 | None | 2 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL316300 | 107217 | None | 2 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 9809961 | 107217 | None | 2 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL316300 | 107217 | None | 2 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 9809961 | 107217 | None | 2 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316300 | 107217 | None | 2 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 44323350 | 107075 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 635 | 11 | 1 | 9 | 6.6 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3cccc(Cl)c3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL315400 | 107075 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 635 | 11 | 1 | 9 | 6.6 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3cccc(Cl)c3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 57380414 | 70554 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1947131 | 70554 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 10028545 | 21012 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 490 | 8 | 1 | 6 | 4.9 | CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL131156 | 21012 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 490 | 8 | 1 | 6 | 4.9 | CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm00050a002 | |||
| 10009273 | 107281 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 636 | 11 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316706 | 107281 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 636 | 11 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 | 10.1021/jm00043a020 | |||
| 15236320 | 172709 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 548 | 10 | 1 | 7 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL449095 | 172709 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 548 | 10 | 1 | 7 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 44315059 | 207170 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74144 | 207170 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 2911265 | 100896 | None | 8 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 476 | 4 | 0 | 2 | 6.5 | O=C(N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL293414 | 100896 | None | 8 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 476 | 4 | 0 | 2 | 6.5 | O=C(N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | |||
| 183134 | 207302 | None | 16 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL7550 | 207302 | None | 16 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 9938088 | 102536 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 575 | 12 | 1 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 | 10.1021/jm00015a016 | |||
| CHEMBL304022 | 102536 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 575 | 12 | 1 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 | 10.1021/jm00015a016 | |||
| 15230315 | 54453 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 552 | 8 | 0 | 7 | 5.7 | COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc([N+](=O)[O-])cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL160930 | 54453 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 552 | 8 | 0 | 7 | 5.7 | COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc([N+](=O)[O-])cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | |||
| 14403498 | 101085 | None | 3 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 495 | 7 | 1 | 5 | 4.4 | COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL294558 | 101085 | None | 3 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 495 | 7 | 1 | 5 | 4.4 | COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1016/S0960-894X(01)81007-6 | |||
| 44322234 | 209166 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 620 | 13 | 3 | 8 | 5.1 | CCCCc1nc(SC)c(C(=O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL89769 | 209166 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 620 | 13 | 3 | 8 | 5.1 | CCCCc1nc(SC)c(C(=O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 9986299 | 158543 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL409058 | 158543 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 | 10.1021/jm00043a020 | |||
| 44322235 | 112712 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 620 | 13 | 3 | 7 | 6.0 | CCCCc1nc(SC)c(C(C)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL330302 | 112712 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 620 | 13 | 3 | 7 | 6.0 | CCCCc1nc(SC)c(C(C)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 10032193 | 119209 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 649 | 10 | 2 | 8 | 6.1 | CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL342843 | 119209 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 649 | 10 | 2 | 8 | 6.1 | CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44211506 | 57558 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 557 | 10 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL166338 | 57558 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 557 | 10 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44311456 | 102353 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 792 | 19 | 1 | 10 | 8.6 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL303427 | 102353 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 792 | 19 | 1 | 10 | 8.6 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 71611145 | 184968 | None | 2 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 1072 | 29 | 14 | 13 | -0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4852514 | 184968 | None | 2 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 1072 | 29 | 14 | 13 | -0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| 44303195 | 205672 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 559 | 12 | 1 | 8 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(F)c1 | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL64411 | 205672 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 559 | 12 | 1 | 8 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(F)c1 | 10.1016/S0960-894X(01)80554-0 | |||
| 44331176 | 210814 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 732 | 18 | 1 | 8 | 7.8 | CCCc1nc(CC)c(C(=O)CCN(CCC)C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| CHEMBL99438 | 210814 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 732 | 18 | 1 | 8 | 7.8 | CCCc1nc(CC)c(C(=O)CCN(CCC)C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| 10010311 | 30535 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 753 | 12 | 2 | 8 | 7.8 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL139325 | 30535 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 753 | 12 | 2 | 8 | 7.8 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10327728 | 98175 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL273542 | 98175 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10439819 | 169992 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL444065 | 169992 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9850834 | 154752 | None | 20 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | |||
| CHEMBL39959 | 154752 | None | 20 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | |||
| 9850834 | 154752 | None | 20 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmcl.2015.10.084 | |||
| CHEMBL39959 | 154752 | None | 20 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmcl.2015.10.084 | |||
| 9850834 | 154752 | None | 20 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm031031i | |||
| CHEMBL39959 | 154752 | None | 20 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm031031i | |||
| 19102786 | 209647 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 648 | 9 | 1 | 8 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL92533 | 209647 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 648 | 9 | 1 | 8 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 44309702 | 206198 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 591 | 13 | 2 | 8 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL67805 | 206198 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 591 | 13 | 2 | 8 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 10439837 | 16360 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL122917 | 16360 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10462598 | 114200 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL332909 | 114200 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | |||
| 10327537 | 116741 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 719 | 12 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL337118 | 116741 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 719 | 12 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10439848 | 119274 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 717 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL343309 | 119274 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 717 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 9852499 | 120527 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 647 | 11 | 3 | 8 | 6.1 | CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL354080 | 120527 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 647 | 11 | 3 | 8 | 6.1 | CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44314761 | 102909 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL305647 | 102909 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44315350 | 105274 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311484 | 105274 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44304123 | 203033 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL59913 | 203033 | None | 0 | Rat | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44210585 | 120471 | None | 0 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 647 | 14 | 3 | 8 | 6.2 | CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL353615 | 120471 | None | 0 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 647 | 14 | 3 | 8 | 6.2 | CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10327309 | 113955 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL332576 | 113955 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1021/jm00019a004 | |||
| 44322096 | 98454 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 622 | 12 | 4 | 8 | 4.8 | CCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL275449 | 98454 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 622 | 12 | 4 | 8 | 4.8 | CCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 10259411 | 30666 | None | 0 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 734 | 13 | 3 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL139452 | 30666 | None | 0 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 734 | 13 | 3 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL408886 | 215197 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CCSS2 | 10.1021/jm00065a013 | |||||
| 22402420 | 49076 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 521 | 9 | 1 | 4 | 5.5 | COc1ccc2c(c1OCCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL156129 | 49076 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 521 | 9 | 1 | 4 | 5.5 | COc1ccc2c(c1OCCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| 19939454 | 210016 | None | 0 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 761 | 15 | 2 | 8 | 8.2 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL94793 | 210016 | None | 0 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 761 | 15 | 2 | 8 | 8.2 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | |||
| 10003751 | 18845 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 447 | 5 | 1 | 2 | 5.5 | O=C(O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| CHEMBL128066 | 18845 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 447 | 5 | 1 | 2 | 5.5 | O=C(O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| 5311348 | 100727 | None | 1 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 480 | 6 | 2 | 5 | 4.0 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N | 10.1021/jm00077a001 | |||
| CHEMBL292277 | 100727 | None | 1 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 480 | 6 | 2 | 5 | 4.0 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N | 10.1021/jm00077a001 | |||
| 10455982 | 116711 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 441 | 8 | 1 | 2 | 5.6 | CCCCCc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1021/jm00077a001 | |||
| CHEMBL336991 | 116711 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 441 | 8 | 1 | 2 | 5.6 | CCCCCc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1021/jm00077a001 | |||
| 10435148 | 118198 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 477 | 6 | 1 | 3 | 5.5 | COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 | 10.1021/jm00077a001 | |||
| CHEMBL340778 | 118198 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 477 | 6 | 1 | 3 | 5.5 | COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 | 10.1021/jm00077a001 | |||
| 44303430 | 101088 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 541 | 12 | 1 | 8 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)cc1 | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL294578 | 101088 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 541 | 12 | 1 | 8 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)cc1 | 10.1016/S0960-894X(01)80554-0 | |||
| 44303878 | 98745 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 452 | 5 | 1 | 3 | 4.3 | CC(C)N(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)C(C)C | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL277567 | 98745 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 452 | 5 | 1 | 3 | 4.3 | CC(C)N(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)C(C)C | 10.1016/S0960-894X(01)81007-6 | |||
| 22402433 | 49611 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 508 | 7 | 2 | 5 | 5.2 | COc1ccc2c(c1Oc1ccc(N)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL156587 | 49611 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 508 | 7 | 2 | 5 | 5.2 | COc1ccc2c(c1Oc1ccc(N)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| 9851082 | 101074 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| CHEMBL294512 | 101074 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| 44311543 | 104196 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 643 | 14 | 1 | 8 | 6.3 | CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL309455 | 104196 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 643 | 14 | 1 | 8 | 6.3 | CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 10410436 | 117868 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 430 | 5 | 1 | 3 | 4.4 | COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(C)c2ccccc2)C3)cc1 | 10.1021/jm00077a001 | |||
| CHEMBL340187 | 117868 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 430 | 5 | 1 | 3 | 4.4 | COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(C)c2ccccc2)C3)cc1 | 10.1021/jm00077a001 | |||
| 18950592 | 16797 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 | 10.1021/jm00075a033 | |||
| CHEMBL124541 | 16797 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 | 10.1021/jm00075a033 | |||
| 44309902 | 103172 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 598 | 12 | 1 | 7 | 7.4 | CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL307757 | 103172 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 598 | 12 | 1 | 7 | 7.4 | CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 44311663 | 206647 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 561 | 10 | 2 | 7 | 5.8 | CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70796 | 206647 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 561 | 10 | 2 | 7 | 5.8 | CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311569 | 207162 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 625 | 13 | 2 | 7 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL74113 | 207162 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 625 | 13 | 2 | 7 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44381714 | 59138 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 732 | 11 | 1 | 7 | 7.6 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169827 | 59138 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 732 | 11 | 1 | 7 | 7.6 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10416501 | 112473 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 626 | 9 | 1 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329759 | 112473 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 626 | 9 | 1 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 10349392 | 210509 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 659 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97557 | 210509 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 659 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 | 10.1021/jm00043a020 | |||
| 44311607 | 206641 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 517 | 9 | 3 | 8 | 4.5 | CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70770 | 206641 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 517 | 9 | 3 | 8 | 4.5 | CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44211673 | 59740 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 678 | 4 | 1 | 8 | 6.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL172376 | 59740 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 678 | 4 | 1 | 8 | 6.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| 44300826 | 201194 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 544 | 7 | 1 | 7 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL58291 | 201194 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 544 | 7 | 1 | 7 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 10099830 | 108547 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 584 | 9 | 1 | 7 | 4.9 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL319955 | 108547 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 584 | 9 | 1 | 7 | 4.9 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | |||
| 44270278 | 98918 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 443 | 8 | 1 | 5 | 5.4 | CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL278983 | 98918 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 443 | 8 | 1 | 5 | 5.4 | CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 73349424 | 92684 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 495 | 7 | 1 | 4 | 6.3 | CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435833 | 92684 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 495 | 7 | 1 | 4 | 6.3 | CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 44379268 | 120118 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 666 | 11 | 1 | 8 | 6.4 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL350554 | 120118 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 666 | 11 | 1 | 8 | 6.4 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10417431 | 109164 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 718 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL321363 | 109164 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 718 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 | 10.1021/jm00043a020 | |||
| 44322967 | 168045 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 712 | 15 | 1 | 10 | 7.0 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccn(C(C(=O)OC(C)C)c4ccccc4)c(=O)c32)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL431592 | 168045 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 712 | 15 | 1 | 10 | 7.0 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccn(C(C(=O)OC(C)C)c4ccccc4)c(=O)c32)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 10032583 | 12353 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 690 | 10 | 1 | 8 | 7.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1185398 | 12353 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 690 | 10 | 1 | 8 | 7.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL411487 | 12353 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 690 | 10 | 1 | 8 | 7.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 | 10.1021/jm00043a020 | |||
| 3082918 | 95122 | None | 0 | Rat | Binding | pIC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 340 | 7 | 1 | 3 | 4.2 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | |||
| CHEMBL25528 | 95122 | None | 0 | Rat | Binding | pIC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 340 | 7 | 1 | 3 | 4.2 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | |||
| 60148656 | 92680 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 457 | 7 | 2 | 5 | 5.9 | CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435829 | 92680 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 457 | 7 | 2 | 5 | 5.9 | CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 44322233 | 111693 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 644 | 12 | 2 | 11 | 4.5 | CCCCc1nc(SC)c(C(=O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL328480 | 111693 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 644 | 12 | 2 | 11 | 4.5 | CCCCc1nc(SC)c(C(=O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 10047444 | 100401 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 414 | 9 | 1 | 4 | 5.7 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | |||
| CHEMBL289543 | 100401 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 414 | 9 | 1 | 4 | 5.7 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | |||
| 10010047 | 210410 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 712 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97020 | 210410 | None | 0 | Rat | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 712 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 | 10.1021/jm00043a020 | |||
| 164611656 | 184843 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 1067 | 27 | 14 | 12 | 0.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4850726 | 184843 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 1067 | 27 | 14 | 12 | 0.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1016/j.bmcl.2021.128086 | |||
| 44348408 | 113637 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 | 10.1021/jm00075a033 | |||
| CHEMBL332239 | 113637 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 | 10.1021/jm00075a033 | |||
| 10055096 | 98338 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 656 | 15 | 1 | 7 | 7.3 | CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL274712 | 98338 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 656 | 15 | 1 | 7 | 7.3 | CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| 10054188 | 209980 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 592 | 9 | 1 | 7 | 5.1 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94582 | 209980 | None | 0 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 592 | 9 | 1 | 7 | 5.1 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 9939191 | 99000 | None | 1 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL279629 | 99000 | None | 1 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL97539 | 99000 | None | 1 | Rat | Binding | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| 9829012 | 92608 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL24322 | 92608 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 9829012 | 92608 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL24322 | 92608 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 44376781 | 56288 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 517 | 10 | 2 | 6 | 4.8 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL162859 | 56288 | None | 0 | Rat | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 517 | 10 | 2 | 6 | 4.8 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 9829012 | 92608 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm058225d | |||
| CHEMBL24322 | 92608 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm058225d | |||
| 9895635 | 112086 | None | 0 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL328941 | 112086 | None | 0 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 | 10.1021/jm00043a020 | |||
| 10484119 | 168211 | None | 0 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 628 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL432822 | 168211 | None | 0 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 628 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10075750 | 107614 | None | 0 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 532 | 10 | 1 | 7 | 4.8 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL318891 | 107614 | None | 0 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 532 | 10 | 1 | 7 | 4.8 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 44323291 | 208999 | None | 0 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 615 | 12 | 1 | 9 | 6.4 | CCCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL88600 | 208999 | None | 0 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 615 | 12 | 1 | 9 | 6.4 | CCCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 10095637 | 49981 | None | 0 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 457 | 9 | 1 | 5 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15689 | 49981 | None | 0 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 457 | 9 | 1 | 5 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 10009735 | 158297 | None | 0 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 676 | 3 | 1 | 7 | 6.9 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL408798 | 158297 | None | 0 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 676 | 3 | 1 | 7 | 6.9 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| 10004112 | 25538 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm9504722 | |||
| CHEMBL135089 | 25538 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm9504722 | |||
| 44311683 | 105674 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 789 | 16 | 1 | 10 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL312301 | 105674 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 789 | 16 | 1 | 10 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311618 | 163432 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 772 | 16 | 2 | 8 | 7.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL419073 | 163432 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 772 | 16 | 2 | 8 | 7.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311581 | 167936 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 720 | 17 | 2 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL430792 | 167936 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 720 | 17 | 2 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311415 | 206543 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 705 | 17 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70161 | 206543 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 705 | 17 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311582 | 206666 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 790 | 21 | 1 | 9 | 8.5 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70868 | 206666 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 790 | 21 | 1 | 9 | 8.5 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44321790 | 209070 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 634 | 13 | 4 | 8 | 4.9 | C=CC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL89052 | 209070 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 634 | 13 | 4 | 8 | 4.9 | C=CC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 44381656 | 120332 | None | 0 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 656 | 12 | 2 | 9 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352458 | 120332 | None | 0 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 656 | 12 | 2 | 9 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44330904 | 4347 | None | 0 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 698 | 19 | 1 | 8 | 7.3 | CCCC(=O)N(CCC)CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| CHEMBL101039 | 4347 | None | 0 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 698 | 19 | 1 | 8 | 7.3 | CCCC(=O)N(CCC)CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | |||
| 10373120 | 117665 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL340078 | 117665 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 15284887 | 165575 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 607 | 6 | 2 | 5 | 4.7 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc(I)c1O | 10.1016/S0960-894X(00)80690-3 | |||
| CHEMBL424004 | 165575 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 607 | 6 | 2 | 5 | 4.7 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc(I)c1O | 10.1016/S0960-894X(00)80690-3 | |||
| 44381427 | 120337 | None | 0 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 632 | 14 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352503 | 120337 | None | 0 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 632 | 14 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10259525 | 15626 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL122158 | 15626 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9987614 | 168676 | None | 0 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 747 | 12 | 2 | 8 | 7.9 | CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL435792 | 168676 | None | 0 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 747 | 12 | 2 | 8 | 7.9 | CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44321823 | 208677 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 696 | 13 | 4 | 8 | 6.1 | CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL86617 | 208677 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 696 | 13 | 4 | 8 | 6.1 | CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 19939753 | 206212 | None | 0 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 605 | 13 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL67921 | 206212 | None | 0 | Rat | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 605 | 13 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 10100951 | 115108 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL334300 | 115108 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| 44371045 | 119875 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 508 | 7 | 1 | 4 | 6.0 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL348363 | 119875 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 508 | 7 | 1 | 4 | 6.0 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| 10344854 | 57622 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 474 | 7 | 2 | 6 | 5.2 | CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC=C2C(=O)O | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1668009 | 57622 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 474 | 7 | 2 | 6 | 5.2 | CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC=C2C(=O)O | 10.1016/j.bmc.2010.10.043 | |||
| 10053595 | 103171 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 562 | 10 | 2 | 8 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL307756 | 103171 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 562 | 10 | 2 | 8 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311638 | 102980 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 613 | 18 | 1 | 8 | 6.7 | CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306186 | 102980 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 613 | 18 | 1 | 8 | 6.7 | CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44303230 | 203103 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL59957 | 203103 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80554-0 | |||
| 44303232 | 205172 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 434 | 8 | 1 | 6 | 4.8 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Cl | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL61754 | 205172 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 434 | 8 | 1 | 6 | 4.8 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Cl | 10.1016/S0960-894X(01)80554-0 | |||
| 44311636 | 206587 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 549 | 9 | 2 | 9 | 3.8 | CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70389 | 206587 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 549 | 9 | 2 | 9 | 3.8 | CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 15222103 | 206997 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 678 | 12 | 2 | 9 | 5.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL72819 | 206997 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 678 | 12 | 2 | 9 | 5.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44376746 | 119923 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 568 | 16 | 2 | 7 | 5.9 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL348758 | 119923 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 568 | 16 | 2 | 7 | 5.9 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 44303230 | 203103 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL59957 | 203103 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 11764669 | 66841 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 634 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL18606 | 66841 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 634 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10233056 | 107215 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 637 | 10 | 1 | 8 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316297 | 107215 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 637 | 10 | 1 | 8 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 | 10.1021/jm00043a020 | |||
| 10009478 | 112535 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329858 | 112535 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1021/jm00043a020 | |||
| 10032361 | 112789 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330463 | 112789 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 | 10.1021/jm00043a020 | |||
| 10100723 | 209907 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 646 | 9 | 1 | 7 | 6.1 | CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94176 | 209907 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 646 | 9 | 1 | 7 | 6.1 | CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 44303230 | 203103 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL59957 | 203103 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| 11741658 | 18820 | None | 0 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 399 | 4 | 0 | 3 | 4.3 | COC(=O)C1Cc2c(C)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| CHEMBL127844 | 18820 | None | 0 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 399 | 4 | 0 | 3 | 4.3 | COC(=O)C1Cc2c(C)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| 108185 | 1614 | None | 50 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00050a002 | |||
| 586 | 1614 | None | 50 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00050a002 | |||
| CHEMBL907 | 1614 | None | 50 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00050a002 | |||
| 1610 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| 3941 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| 3961 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| 3961.0 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| 590 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| CHEMBL191 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| DB00678 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| 183134 | 207302 | None | 16 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL7550 | 207302 | None | 16 | Rat | Binding | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00050a002 | |||
| 44475943 | 188815 | None | 0 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 1508 | 12 | 8 | 32 | 4.9 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | |||
| CHEMBL504492 | 188815 | None | 0 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 1508 | 12 | 8 | 32 | 4.9 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | |||
| 44309703 | 172657 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL448476 | 172657 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 10417031 | 107442 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 669 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL317864 | 107442 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 669 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 9986951 | 210226 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL95955 | 210226 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 | 10.1021/jm00043a020 | |||
| 10416422 | 210458 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 620 | 9 | 1 | 7 | 5.8 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97295 | 210458 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 620 | 9 | 1 | 7 | 5.8 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10416836 | 107960 | None | 0 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 651 | 11 | 1 | 8 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL319313 | 107960 | None | 0 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 651 | 11 | 1 | 8 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 | 10.1021/jm00043a020 | |||
| 9888876 | 49004 | None | 0 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15606 | 49004 | None | 0 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 73353934 | 92675 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 469 | 9 | 2 | 4 | 6.4 | CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435824 | 92675 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 469 | 9 | 2 | 4 | 6.4 | CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| 10372093 | 112825 | None | 0 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330533 | 112825 | None | 0 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 | 10.1021/jm00043a020 | |||
| 44376822 | 120117 | None | 0 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 565 | 10 | 1 | 7 | 5.5 | CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL350493 | 120117 | None | 0 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 565 | 10 | 1 | 7 | 5.5 | CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 44274823 | 99129 | None | 0 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL280526 | 99129 | None | 0 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 9830839 | 106987 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 2 | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL314812 | 106987 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 2 | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1021/jm00043a020 | |||
| 44379183 | 120879 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 571 | 10 | 1 | 6 | 6.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL355708 | 120879 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 571 | 10 | 1 | 6 | 6.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 11758341 | 117347 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 603 | 13 | 1 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 | 10.1021/jm00019a005 | |||
| CHEMBL339544 | 117347 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 603 | 13 | 1 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 | 10.1021/jm00019a005 | |||
| 10326942 | 112457 | None | 0 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329693 | 112457 | None | 0 | Rat | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 | 10.1021/jm00043a020 | |||
| 10100074 | 112623 | None | 0 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 598 | 9 | 1 | 6 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330007 | 112623 | None | 0 | Rat | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 598 | 9 | 1 | 6 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 44379184 | 57466 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 602 | 14 | 2 | 7 | 5.9 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL165541 | 57466 | None | 0 | Rat | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 602 | 14 | 2 | 7 | 5.9 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44323351 | 107076 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 635 | 11 | 1 | 9 | 6.6 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3Cl)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL315401 | 107076 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 635 | 11 | 1 | 9 | 6.6 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3Cl)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 10394829 | 119424 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 683 | 10 | 2 | 8 | 6.5 | CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL344387 | 119424 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 683 | 10 | 2 | 8 | 6.5 | CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10485202 | 119484 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 747 | 14 | 1 | 8 | 7.4 | CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL344811 | 119484 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 747 | 14 | 1 | 8 | 7.4 | CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 9873751 | 96473 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 614 | 12 | 1 | 8 | 5.9 | CCCCc1nc2ccn(C(C(=O)N(CC)CC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL261981 | 96473 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 614 | 12 | 1 | 8 | 5.9 | CCCCc1nc2ccn(C(C(=O)N(CC)CC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 44323290 | 106956 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 587 | 10 | 1 | 9 | 5.6 | CCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL314603 | 106956 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 587 | 10 | 1 | 9 | 5.6 | CCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 44381431 | 58518 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 578 | 11 | 1 | 9 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL168346 | 58518 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 578 | 11 | 1 | 9 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10078452 | 107334 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL317061 | 107334 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm00043a020 | |||
| 44377123 | 120039 | None | 0 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 481 | 10 | 2 | 6 | 3.9 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349856 | 120039 | None | 0 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 481 | 10 | 2 | 6 | 3.9 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10391038 | 116996 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 494 | 13 | 0 | 6 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1021/jm00019a005 | |||
| CHEMBL338514 | 116996 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 494 | 13 | 0 | 6 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1021/jm00019a005 | |||
| 44309701 | 103241 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 609 | 11 | 2 | 7 | 6.3 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL308238 | 103241 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 609 | 11 | 2 | 7 | 6.3 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| 15230312 | 48928 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1cc2c(cc1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL155987 | 48928 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1cc2c(cc1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| 164620345 | 186319 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 1084 | 26 | 13 | 13 | 0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4873167 | 186319 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 1084 | 26 | 13 | 13 | 0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| 10054324 | 98406 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 600 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL275160 | 98406 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 600 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 9908300 | 15553 | None | 0 | Rat | Binding | pIC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 387 | 8 | 2 | 5 | 3.9 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1021/jm00053a013 | |||
| CHEMBL12190 | 15553 | None | 0 | Rat | Binding | pIC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 387 | 8 | 2 | 5 | 3.9 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1021/jm00053a013 | |||
| 73357016 | 92676 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 503 | 8 | 2 | 4 | 7.0 | CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435825 | 92676 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 503 | 8 | 2 | 4 | 7.0 | CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL408773 | 215191 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSS2 | 10.1021/jm00065a013 | |||||
| 10462933 | 16889 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL125008 | 16889 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9850834 | 154752 | None | 20 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | |||
| CHEMBL39959 | 154752 | None | 20 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | |||
| 9874508 | 207138 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL73876 | 207138 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44210586 | 59029 | None | 0 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 619 | 12 | 3 | 8 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169221 | 59029 | None | 0 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 619 | 12 | 3 | 8 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10101690 | 116925 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338137 | 116925 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10395394 | 31888 | None | 0 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 767 | 13 | 2 | 8 | 7.7 | CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL140708 | 31888 | None | 0 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 767 | 13 | 2 | 8 | 7.7 | CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44314780 | 103133 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL307430 | 103133 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10010207 | 30203 | None | 0 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 735 | 13 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL139041 | 30203 | None | 0 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 735 | 13 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44315180 | 102951 | None | 0 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL305956 | 102951 | None | 0 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 19763341 | 62005 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 448 | 8 | 1 | 6 | 5.2 | CCCc1nc(-c2ccccc2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00137a004 | |||
| CHEMBL177435 | 62005 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 448 | 8 | 1 | 6 | 5.2 | CCCc1nc(-c2ccccc2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00137a004 | |||
| 5311345 | 3021 | None | 38 | Human | Binding | pIC50 | = | 8.2 | 8.2 | 10 | 2 | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1016/S0960-894X(01)80517-5 | |||
| 597 | 3021 | None | 38 | Human | Binding | pIC50 | = | 8.2 | 8.2 | 10 | 2 | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL321820 | 3021 | None | 38 | Human | Binding | pIC50 | = | 8.2 | 8.2 | 10 | 2 | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1016/S0960-894X(01)80517-5 | |||
| 5311345 | 3021 | None | 38 | Human | Binding | pIC50 | = | 8.2 | 8.2 | 10 | 2 | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1016/S0960-894X(01)81122-7 | |||
| 597 | 3021 | None | 38 | Human | Binding | pIC50 | = | 8.2 | 8.2 | 10 | 2 | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL321820 | 3021 | None | 38 | Human | Binding | pIC50 | = | 8.2 | 8.2 | 10 | 2 | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1016/S0960-894X(01)81122-7 | |||
| 9804437 | 118129 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 463 | 6 | 1 | 3 | 5.6 | O=C(O)C1Cc2cc(Oc3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| CHEMBL340467 | 118129 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 463 | 6 | 1 | 3 | 5.6 | O=C(O)C1Cc2cc(Oc3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| 9915892 | 103673 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL308703 | 103673 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 10417351 | 210417 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 706 | 10 | 1 | 8 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97075 | 210417 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 706 | 10 | 1 | 8 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 9895984 | 207207 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74476 | 207207 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| 9915892 | 103673 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL308703 | 103673 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 19385644 | 98805 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 519 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL278061 | 98805 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 519 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | |||
| 44311429 | 207074 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 649 | 11 | 1 | 8 | 6.8 | CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL73369 | 207074 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 649 | 11 | 1 | 8 | 6.8 | CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 10318033 | 118337 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 387 | 4 | 2 | 3 | 3.6 | O=C(O)C1Cc2cc(O)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| CHEMBL340933 | 118337 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 387 | 4 | 2 | 3 | 3.6 | O=C(O)C1Cc2cc(O)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| 44311342 | 102236 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 611 | 12 | 3 | 7 | 5.9 | CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL302760 | 102236 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 611 | 12 | 3 | 7 | 5.9 | CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 15222094 | 103029 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 596 | 10 | 2 | 8 | 5.4 | CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL306489 | 103029 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 596 | 10 | 2 | 8 | 5.4 | CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 15222101 | 158654 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 642 | 12 | 2 | 9 | 4.2 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL409170 | 158654 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 642 | 12 | 2 | 9 | 4.2 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311688 | 104251 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 554 | 10 | 2 | 8 | 3.5 | CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL309820 | 104251 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 554 | 10 | 2 | 8 | 3.5 | CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 14952909 | 148163 | None | 0 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1C(=O)O | 10.1021/jm00108a043 | |||
| CHEMBL39349 | 148163 | None | 0 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1C(=O)O | 10.1021/jm00108a043 | |||
| 73357018 | 92685 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 517 | 8 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435834 | 92685 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 517 | 8 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 19385598 | 98916 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 457 | 8 | 1 | 6 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL278955 | 98916 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 457 | 8 | 1 | 6 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 | 10.1016/0960-894X(95)00185-V | |||
| 44379291 | 120580 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 702 | 15 | 2 | 8 | 7.5 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL354535 | 120580 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 702 | 15 | 2 | 8 | 7.5 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 14952916 | 100200 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 425 | 10 | 1 | 6 | 5.0 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc([N+](=O)[O-])cc1 | 10.1021/jm00108a043 | |||
| CHEMBL287762 | 100200 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 425 | 10 | 1 | 6 | 5.0 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc([N+](=O)[O-])cc1 | 10.1021/jm00108a043 | |||
| 44384872 | 60015 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 575 | 9 | 3 | 7 | 4.4 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL173455 | 60015 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 575 | 9 | 3 | 7 | 4.4 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL440063 | 216318 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | None | None | None | CNCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](CCCN=C(N)N)NC(=O)CNC)CSSC[C@H](C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00065a013 | |||||
| 44315349 | 60410 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL17487 | 60410 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44315350 | 105274 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311484 | 105274 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 10259334 | 210497 | None | 0 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 724 | 13 | 1 | 10 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97500 | 210497 | None | 0 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 724 | 13 | 1 | 10 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm00043a020 | |||
| 114899 | 3020 | None | 15 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 10.1021/jm00137a004 | |||
| 596 | 3020 | None | 15 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 10.1021/jm00137a004 | |||
| CHEMBL1188080 | 3020 | None | 15 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 10.1021/jm00137a004 | |||
| 5311348 | 100727 | None | 1 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 480 | 6 | 2 | 5 | 4.0 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N | 10.1021/jm9504722 | |||
| CHEMBL292277 | 100727 | None | 1 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 480 | 6 | 2 | 5 | 4.0 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N | 10.1021/jm9504722 | |||
| 44379086 | 56594 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 543 | 9 | 1 | 6 | 5.4 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL164174 | 56594 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 543 | 9 | 1 | 6 | 5.4 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44311074 | 104956 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 732 | 15 | 1 | 10 | 6.2 | CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL311253 | 104956 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 732 | 15 | 1 | 10 | 6.2 | CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 9938088 | 102536 | None | 0 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 575 | 12 | 1 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL304022 | 102536 | None | 0 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 575 | 12 | 1 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 | 10.1016/S0960-894X(01)80554-0 | |||
| 9851889 | 102129 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL302102 | 102129 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44303883 | 205360 | None | 0 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 634 | 11 | 1 | 3 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL62744 | 205360 | None | 0 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 634 | 11 | 1 | 3 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 9938088 | 102536 | None | 0 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 575 | 12 | 1 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 | 10.1021/jm00015a016 | |||
| CHEMBL304022 | 102536 | None | 0 | Rat | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 575 | 12 | 1 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 | 10.1021/jm00015a016 | |||
| 44382994 | 96957 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 933 | 25 | 7 | 10 | 5.8 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)[C@@H](N)CCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 10.1016/S0960-894X(00)80690-3 | |||
| CHEMBL265790 | 96957 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 933 | 25 | 7 | 10 | 5.8 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)[C@@H](N)CCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 10.1016/S0960-894X(00)80690-3 | |||
| CHEMBL384125 | 214777 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CSS[C@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00065a013 | |||||
| 44381657 | 59075 | None | 0 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169488 | 59075 | None | 0 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10372550 | 164611 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL421478 | 164611 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44314823 | 161980 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL415073 | 161980 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44314822 | 103004 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL306362 | 103004 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44303885 | 205361 | None | 0 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 538 | 12 | 1 | 4 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(OC)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL62754 | 205361 | None | 0 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 538 | 12 | 1 | 4 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(OC)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 10413312 | 117375 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 491 | 6 | 1 | 3 | 5.8 | COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1021/jm00077a001 | |||
| CHEMBL339706 | 117375 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 491 | 6 | 1 | 3 | 5.8 | COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1021/jm00077a001 | |||
| 10344278 | 118247 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 461 | 6 | 1 | 2 | 5.4 | O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| CHEMBL340902 | 118247 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 461 | 6 | 1 | 2 | 5.4 | O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| 44323559 | 209469 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 628 | 10 | 1 | 9 | 4.9 | CCCCc1nc2ccn(C(C(=O)N3CCOCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL91465 | 209469 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 628 | 10 | 1 | 9 | 4.9 | CCCCc1nc2ccn(C(C(=O)N3CCOCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 44311451 | 104157 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 576 | 10 | 2 | 8 | 5.1 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL309367 | 104157 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 576 | 10 | 2 | 8 | 5.1 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 18655106 | 202925 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 464 | 10 | 0 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL59854 | 202925 | None | 0 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 464 | 10 | 0 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 | 10.1016/S0960-894X(01)81007-6 | |||
| 15296723 | 48879 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 499 | 7 | 1 | 4 | 5.2 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Cc1c(Cl)cccc1Cl)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL155938 | 48879 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 499 | 7 | 1 | 4 | 5.2 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Cc1c(Cl)cccc1Cl)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| 14403498 | 101085 | None | 3 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 495 | 7 | 1 | 5 | 4.4 | COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1021/jm9504722 | |||
| CHEMBL294558 | 101085 | None | 3 | Rat | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 495 | 7 | 1 | 5 | 4.4 | COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1021/jm9504722 | |||
| 164612059 | 184607 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 1123 | 30 | 14 | 12 | 1.6 | CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](C)CC)C1=O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4847398 | 184607 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 1123 | 30 | 14 | 12 | 1.6 | CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](C)CC)C1=O | 10.1016/j.bmcl.2021.128086 | |||
| 44303614 | 203123 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 478 | 8 | 1 | 6 | 4.9 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL59974 | 203123 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 478 | 8 | 1 | 6 | 4.9 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br | 10.1016/S0960-894X(01)80554-0 | |||
| 15222070 | 102352 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 577 | 9 | 2 | 9 | 3.8 | CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL303426 | 102352 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 577 | 9 | 2 | 9 | 3.8 | CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311648 | 206985 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 577 | 11 | 2 | 9 | 4.5 | CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL72721 | 206985 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 577 | 11 | 2 | 9 | 4.5 | CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 10349256 | 111519 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 647 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327569 | 111519 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 647 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 | 10.1021/jm00043a020 | |||
| 10461595 | 210579 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97964 | 210579 | None | 0 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 | 10.1021/jm00043a020 | |||
| 10254358 | 117559 | None | 0 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 475 | 6 | 0 | 3 | 5.5 | COC(=O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| CHEMBL340018 | 117559 | None | 0 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 475 | 6 | 0 | 3 | 5.5 | COC(=O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| 44311472 | 103847 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 669 | 14 | 3 | 8 | 5.7 | CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL308943 | 103847 | None | 0 | Human | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 669 | 14 | 3 | 8 | 5.7 | CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44377199 | 57436 | None | 0 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 531 | 10 | 2 | 6 | 4.9 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL165349 | 57436 | None | 0 | Rat | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 531 | 10 | 2 | 6 | 4.9 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 73353933 | 92672 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 554 | 11 | 2 | 6 | 5.2 | CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435821 | 92672 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 554 | 11 | 2 | 6 | 5.2 | CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 10078132 | 107307 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316904 | 107307 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 | 10.1021/jm00043a020 | |||
| 10078048 | 106936 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 654 | 12 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL314514 | 106936 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 654 | 12 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1021/jm00043a020 | |||
| 10411441 | 51805 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15850 | 51805 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| 15230316 | 120156 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 522 | 7 | 1 | 6 | 5.3 | COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc(N)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL350875 | 120156 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 522 | 7 | 1 | 6 | 5.3 | COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc(N)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | |||
| 44348259 | 16039 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 575 | 12 | 1 | 5 | 8.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 | 10.1021/jm00075a033 | |||
| CHEMBL122367 | 16039 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 575 | 12 | 1 | 5 | 8.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 | 10.1021/jm00075a033 | |||
| 1610 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 3941 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 3961 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 3961.0 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 590 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| CHEMBL191 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| DB00678 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 1610 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 4.1 | 4.1 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| 3941 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 4.1 | 4.1 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| 3961 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 4.1 | 4.1 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| 3961.0 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 4.1 | 4.1 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| 590 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 4.1 | 4.1 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| CHEMBL191 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 4.1 | 4.1 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| DB00678 | 2347 | None | 64 | Rat | Binding | pIC50 | = | 4.1 | 4.1 | - | 5 | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| 10393837 | 168047 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 602 | 10 | 1 | 8 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL431619 | 168047 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 602 | 10 | 1 | 8 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 | 10.1021/jm00043a020 | |||
| 44211672 | 158298 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 706 | 4 | 1 | 8 | 7.4 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL408799 | 158298 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 706 | 4 | 1 | 8 | 7.4 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| 9892451 | 48754 | None | 24 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL155836 | 48754 | None | 24 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1021/acs.jmedchem.9b01780 | |||
| 15296726 | 51886 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 551 | 9 | 2 | 5 | 5.1 | COc1ccc2c(c1OCc1ccc(C(=O)O)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL158557 | 51886 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 551 | 9 | 2 | 5 | 5.1 | COc1ccc2c(c1OCc1ccc(C(=O)O)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| 18950598 | 15549 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C | 10.1021/jm00075a033 | |||
| CHEMBL121891 | 15549 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C | 10.1021/jm00075a033 | |||
| 10483888 | 111518 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327563 | 111518 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1021/jm00043a020 | |||
| 18950607 | 50432 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 489 | 9 | 1 | 5 | 6.2 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15729 | 50432 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 489 | 9 | 1 | 5 | 6.2 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 9933755 | 55062 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 456 | 9 | 1 | 5 | 5.3 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL16165 | 55062 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 456 | 9 | 1 | 5 | 5.3 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 73355475 | 92678 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 517 | 9 | 2 | 4 | 6.9 | CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435827 | 92678 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 517 | 9 | 2 | 4 | 6.9 | CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 9807029 | 205562 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 530 | 11 | 3 | 7 | 4.4 | CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL63998 | 205562 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 530 | 11 | 3 | 7 | 4.4 | CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 | 10.1016/S0960-894X(01)80554-0 | |||
| 9807029 | 205562 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 530 | 11 | 3 | 7 | 4.4 | CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 | 10.1021/jm9504722 | |||
| CHEMBL63998 | 205562 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 530 | 11 | 3 | 7 | 4.4 | CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 | 10.1021/jm9504722 | |||
| 73347892 | 92674 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 455 | 8 | 2 | 4 | 6.1 | CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435823 | 92674 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 455 | 8 | 2 | 4 | 6.1 | CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 25135102 | 188978 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 1495 | 12 | 10 | 32 | 3.6 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | |||
| CHEMBL507053 | 188978 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 1495 | 12 | 10 | 32 | 3.6 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | |||
| 10349801 | 107994 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL319353 | 107994 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| 19385586 | 49740 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 479 | 8 | 1 | 6 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15669 | 49740 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 479 | 8 | 1 | 6 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10414470 | 17136 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00019a005 | |||
| CHEMBL125542 | 17136 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00019a005 | |||
| 44322176 | 209135 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 646 | 13 | 3 | 11 | 4.4 | CCCCc1nc(SC)c(C(O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL89463 | 209135 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 646 | 13 | 3 | 11 | 4.4 | CCCCc1nc(SC)c(C(O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 44381622 | 59038 | None | 0 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 689 | 12 | 2 | 9 | 5.8 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169279 | 59038 | None | 0 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 689 | 12 | 2 | 9 | 5.8 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44315078 | 207214 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74556 | 207214 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 19102815 | 210337 | None | 0 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96554 | 210337 | None | 0 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 44321775 | 107055 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 588 | 13 | 4 | 8 | 4.4 | CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL315275 | 107055 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 588 | 13 | 4 | 8 | 4.4 | CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 10439858 | 16868 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL124903 | 16868 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 5311345 | 3021 | None | 38 | Human | Binding | pIC50 | = | 8.1 | 8.1 | 10 | 2 | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1016/S0960-894X(00)80690-3 | |||
| 597 | 3021 | None | 38 | Human | Binding | pIC50 | = | 8.1 | 8.1 | 10 | 2 | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1016/S0960-894X(00)80690-3 | |||
| CHEMBL321820 | 3021 | None | 38 | Human | Binding | pIC50 | = | 8.1 | 8.1 | 10 | 2 | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1016/S0960-894X(00)80690-3 | |||
| 44381670 | 120548 | None | 0 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 657 | 11 | 3 | 9 | 6.0 | CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL354298 | 120548 | None | 0 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 657 | 11 | 3 | 9 | 6.0 | CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44315282 | 96677 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL263452 | 96677 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| 10344278 | 118247 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 461 | 6 | 1 | 2 | 5.4 | O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| CHEMBL340902 | 118247 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 461 | 6 | 1 | 2 | 5.4 | O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| 44303211 | 100652 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 584 | 8 | 2 | 6 | 5.8 | CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL291803 | 100652 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 584 | 8 | 2 | 6 | 5.8 | CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br | 10.1016/S0960-894X(01)80554-0 | |||
| 44303404 | 202162 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 525 | 12 | 1 | 7 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)cc1 | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL59331 | 202162 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 525 | 12 | 1 | 7 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)cc1 | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL264450 | 213078 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CCSSCC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00065a013 | |||||
| 44311498 | 102985 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 580 | 10 | 2 | 8 | 4.9 | CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL306216 | 102985 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 580 | 10 | 2 | 8 | 4.9 | CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 15222092 | 103879 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 564 | 10 | 2 | 10 | 3.5 | CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL309165 | 103879 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 564 | 10 | 2 | 10 | 3.5 | CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44379182 | 58139 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 593 | 10 | 1 | 6 | 6.7 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL167662 | 58139 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 593 | 10 | 1 | 6 | 6.7 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 9961192 | 11370 | None | 35 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1179743 | 11370 | None | 35 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97688 | 11370 | None | 35 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 | 10.1021/jm00043a020 | |||
| 10417102 | 209905 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 676 | 10 | 1 | 9 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94145 | 209905 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 676 | 10 | 1 | 9 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 | 10.1021/jm00043a020 | |||
| 44303211 | 100652 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 584 | 8 | 2 | 6 | 5.8 | CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br | 10.1021/jm9504722 | |||
| CHEMBL291803 | 100652 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 584 | 8 | 2 | 6 | 5.8 | CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br | 10.1021/jm9504722 | |||
| 18950608 | 15678 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 | 10.1021/jm00075a033 | |||
| CHEMBL122224 | 15678 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 | 10.1021/jm00075a033 | |||
| 44311568 | 98237 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 607 | 13 | 2 | 8 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL273992 | 98237 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 607 | 13 | 2 | 8 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44270367 | 163318 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 505 | 9 | 1 | 5 | 6.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL418354 | 163318 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 505 | 9 | 1 | 5 | 6.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | |||
| 44377111 | 119948 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 495 | 10 | 1 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349020 | 119948 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 495 | 10 | 1 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 44210830 | 57500 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 461 | 6 | 1 | 6 | 5.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 | 10.1016/S0960-894X(01)80193-1 | |||
| CHEMBL165850 | 57500 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 461 | 6 | 1 | 6 | 5.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 | 10.1016/S0960-894X(01)80193-1 | |||
| 10054708 | 107210 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 626 | 10 | 1 | 7 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316273 | 107210 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 626 | 10 | 1 | 7 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 | 10.1021/jm00043a020 | |||
| 44304163 | 205242 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 496 | 17 | 1 | 3 | 5.7 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(CCCCC)CCCCC)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL62157 | 205242 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 496 | 17 | 1 | 3 | 5.7 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(CCCCC)CCCCC)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 10350378 | 210658 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 796 | 10 | 1 | 8 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL98453 | 210658 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 796 | 10 | 1 | 8 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 | 10.1021/jm00043a020 | |||
| 44574325 | 188858 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 1521 | 12 | 8 | 32 | 4.8 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | |||
| CHEMBL505204 | 188858 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 1521 | 12 | 8 | 32 | 4.8 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | |||
| CHEMBL413034 | 215508 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00065a013 | |||||
| 9874086 | 109169 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 634 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL321367 | 109169 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 634 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 | 10.1021/jm00043a020 | |||
| 19939756 | 5040 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 534 | 9 | 1 | 7 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL105199 | 5040 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 534 | 9 | 1 | 7 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 10349845 | 11366 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 708 | 10 | 1 | 8 | 7.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1179731 | 11366 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 708 | 10 | 1 | 8 | 7.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97271 | 11366 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 708 | 10 | 1 | 8 | 7.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 164627947 | 186491 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 1084 | 26 | 13 | 13 | 0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4875696 | 186491 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 1084 | 26 | 13 | 13 | 0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| 10426066 | 100562 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 318 | 7 | 1 | 3 | 4.0 | CCCCc1ncc(/C=C/C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | |||
| CHEMBL291114 | 100562 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 318 | 7 | 1 | 3 | 4.0 | CCCCc1ncc(/C=C/C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | |||
| 44311454 | 103000 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 692 | 17 | 2 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306340 | 103000 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 692 | 17 | 2 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311436 | 206646 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 725 | 15 | 1 | 8 | 8.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70793 | 206646 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 725 | 15 | 1 | 8 | 8.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44303420 | 204200 | None | 0 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 525 | 12 | 1 | 7 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(C)c1 | 10.1016/S0960-894X(01)80554-0 | |||
| CHEMBL60661 | 204200 | None | 0 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 525 | 12 | 1 | 7 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(C)c1 | 10.1016/S0960-894X(01)80554-0 | |||
| 44321804 | 106036 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 690 | 13 | 4 | 8 | 5.7 | CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL313073 | 106036 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 690 | 13 | 4 | 8 | 5.7 | CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL406290 | 215063 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CCSS[C@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00065a013 | |||||
| 15292111 | 207203 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74442 | 207203 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44315304 | 207468 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL76821 | 207468 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 15230313 | 48628 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 446 | 6 | 1 | 4 | 4.3 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(C)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| CHEMBL155728 | 48628 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 446 | 6 | 1 | 4 | 4.3 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(C)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | |||
| 15292112 | 103003 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL306361 | 103003 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 10368357 | 117335 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 491 | 7 | 1 | 3 | 5.5 | COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 | 10.1021/jm00077a001 | |||
| CHEMBL339485 | 117335 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 491 | 7 | 1 | 3 | 5.5 | COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 | 10.1021/jm00077a001 | |||
| 10344278 | 118247 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 461 | 6 | 1 | 2 | 5.4 | O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| CHEMBL340902 | 118247 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 461 | 6 | 1 | 2 | 5.4 | O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | |||
| 44311739 | 102662 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 563 | 14 | 2 | 7 | 6.2 | CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL304137 | 102662 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 563 | 14 | 2 | 7 | 6.2 | CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | |||
| 44311662 | 102736 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 624 | 17 | 2 | 7 | 5.8 | CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL304620 | 102736 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 624 | 17 | 2 | 7 | 5.8 | CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC | 10.1016/S0960-894X(00)80076-1 | |||
| 44311650 | 103256 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 674 | 14 | 2 | 10 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL308361 | 103256 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 674 | 14 | 2 | 10 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 14952904 | 100218 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 396 | 9 | 2 | 5 | 4.8 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1O | 10.1021/jm00108a043 | |||
| CHEMBL287936 | 100218 | None | 0 | Rat | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 396 | 9 | 2 | 5 | 4.8 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1O | 10.1021/jm00108a043 | |||
| 44309704 | 206736 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 612 | 13 | 1 | 7 | 7.7 | CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL71253 | 206736 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 612 | 13 | 1 | 7 | 7.7 | CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | |||
| 44300798 | 201411 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 558 | 8 | 1 | 7 | 6.1 | CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL58499 | 201411 | None | 0 | Rat | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 558 | 8 | 1 | 7 | 6.1 | CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| 9805344 | 99094 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 483 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL280290 | 99094 | None | 0 | Rat | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 483 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10372718 | 108613 | None | 0 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 722 | 10 | 1 | 7 | 7.4 | O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl | 10.1021/jm00043a020 | |||
| CHEMBL320222 | 108613 | None | 0 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 722 | 10 | 1 | 7 | 7.4 | O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl | 10.1021/jm00043a020 | |||
| 9809280 | 207430 | None | 12 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 544 | 12 | 3 | 7 | 4.8 | CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL76525 | 207430 | None | 12 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 544 | 12 | 3 | 7 | 4.8 | CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1016/0960-894X(95)00479-D | |||
| CHEMBL80370 | 207430 | None | 12 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 544 | 12 | 3 | 7 | 4.8 | CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1016/0960-894X(95)00479-D | |||
| 9809280 | 207430 | None | 12 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 544 | 12 | 3 | 7 | 4.8 | CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1021/jm9504722 | |||
| CHEMBL76525 | 207430 | None | 12 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 544 | 12 | 3 | 7 | 4.8 | CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1021/jm9504722 | |||
| CHEMBL80370 | 207430 | None | 12 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 544 | 12 | 3 | 7 | 4.8 | CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1021/jm9504722 | |||
| 19385623 | 50449 | None | 0 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15730 | 50449 | None | 0 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 | 10.1016/0960-894X(95)00185-V | |||
| 44335530 | 107565 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 520 | 9 | 1 | 7 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL318605 | 107565 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 520 | 9 | 1 | 7 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 44323292 | 163897 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 615 | 12 | 1 | 9 | 6.2 | CCCCc1nc2ccn(C(C(=O)OCC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL420607 | 163897 | None | 0 | Rat | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 615 | 12 | 1 | 9 | 6.2 | CCCCc1nc2ccn(C(C(=O)OCC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 44323363 | 111669 | None | 0 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 558 | 10 | 2 | 8 | 4.5 | CCCCc1nc2ccn(C(C(N)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| CHEMBL328340 | 111669 | None | 0 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 558 | 10 | 2 | 8 | 4.5 | CCCCc1nc2ccn(C(C(N)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | |||
| 44379185 | 57571 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 603 | 13 | 2 | 7 | 5.6 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL166428 | 57571 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 603 | 13 | 2 | 7 | 5.6 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 19742811 | 57438 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 551 | 10 | 2 | 6 | 5.4 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL165354 | 57438 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 551 | 10 | 2 | 6 | 5.4 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 56661223 | 63272 | None | 0 | Human | Binding | pKi | = | 10.1 | 10.1 | - | 1 | ChEMBL | 1149 | 28 | 13 | 14 | 0.8 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm0491492 | |||
| CHEMBL1791308 | 63272 | None | 0 | Human | Binding | pKi | = | 10.1 | 10.1 | - | 1 | ChEMBL | 1149 | 28 | 13 | 14 | 0.8 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm0491492 | |||
| CHEMBL2392353 | 212873 | None | 5 | Human | Binding | pKi | = | 10.0 | 10.0 | - | 1 | ChEMBL | None | None | None | None | 10.1016/j.ejmech.2013.01.044 | |||||
| 10079601 | 214991 | None | 13 | Human | Binding | pKi | = | 9.9 | 9.9 | 4 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | 10.1021/ml500278g | |||||
| CHEMBL404594 | 214991 | None | 13 | Human | Binding | pKi | = | 9.9 | 9.9 | 4 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | 10.1021/ml500278g | |||||
| 10079601 | 214991 | None | 13 | Human | Binding | pKi | = | 9.9 | 9.9 | 4 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | 10.1016/j.bmcl.2015.10.084 | |||||
| CHEMBL404594 | 214991 | None | 13 | Human | Binding | pKi | = | 9.9 | 9.9 | 4 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | 10.1016/j.bmcl.2015.10.084 | |||||
| CHEMBL938 | 218397 | None | 23 | Human | Binding | pKi | = | 9.8 | 9.8 | -1 | 2 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm8007618 | |||||
| CHEMBL216061 | 211775 | None | 17 | Human | Binding | pKi | = | 9.7 | 9.7 | -1 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm050280z | |||||
| 16133225 | 419 | None | 38 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| 172198 | 419 | None | 38 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| 172198.0 | 419 | None | 38 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| 2504 | 419 | None | 38 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| 45266664 | 419 | None | 38 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| 5272 | 419 | None | 38 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| CHEMBL408403 | 419 | None | 38 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| DB11842 | 419 | None | 38 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| 16133225 | 419 | None | 38 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2015.10.084 | |||||
| 172198 | 419 | None | 38 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2015.10.084 | |||||
| 172198.0 | 419 | None | 38 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2015.10.084 | |||||
| 2504 | 419 | None | 38 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2015.10.084 | |||||
| 45266664 | 419 | None | 38 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2015.10.084 | |||||
| 5272 | 419 | None | 38 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2015.10.084 | |||||
| CHEMBL408403 | 419 | None | 38 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2015.10.084 | |||||
| DB11842 | 419 | None | 38 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 4 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2015.10.084 | |||||
| 16133225 | 419 | None | 38 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm030921v | |||||
| 172198 | 419 | None | 38 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm030921v | |||||
| 172198.0 | 419 | None | 38 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm030921v | |||||
| 2504 | 419 | None | 38 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm030921v | |||||
| 45266664 | 419 | None | 38 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm030921v | |||||
| 5272 | 419 | None | 38 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm030921v | |||||
| CHEMBL408403 | 419 | None | 38 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm030921v | |||||
| DB11842 | 419 | None | 38 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm030921v | |||||
| 16133225 | 419 | None | 38 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm0491492 | |||||
| 172198 | 419 | None | 38 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm0491492 | |||||
| 172198.0 | 419 | None | 38 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm0491492 | |||||
| 2504 | 419 | None | 38 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm0491492 | |||||
| 45266664 | 419 | None | 38 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm0491492 | |||||
| 5272 | 419 | None | 38 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm0491492 | |||||
| CHEMBL408403 | 419 | None | 38 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm0491492 | |||||
| DB11842 | 419 | None | 38 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm0491492 | |||||
| 56661223 | 63272 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 1149 | 28 | 13 | 14 | 0.8 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm0491492 | |||
| CHEMBL1791308 | 63272 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 1149 | 28 | 13 | 14 | 0.8 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm0491492 | |||
| 16133225 | 419 | None | 38 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm0613469 | |||||
| 172198 | 419 | None | 38 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm0613469 | |||||
| 172198.0 | 419 | None | 38 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm0613469 | |||||
| 2504 | 419 | None | 38 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm0613469 | |||||
| 45266664 | 419 | None | 38 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm0613469 | |||||
| 5272 | 419 | None | 38 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm0613469 | |||||
| CHEMBL408403 | 419 | None | 38 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm0613469 | |||||
| DB11842 | 419 | None | 38 | Human | Binding | pKi | = | 9.5 | 9.5 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm0613469 | |||||
| 170342155 | 195729 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 531 | 6 | 1 | 3 | 5.6 | CN(C(=O)N1CCC(CC(=O)N(c2ccccc2)C2CCCC(F)(F)C2)(C(=O)O)CC1)c1ccc(F)cc1 | 10.1021/acsmedchemlett.4c00046 | |||
| CHEMBL5409738 | 195729 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 531 | 6 | 1 | 3 | 5.6 | CN(C(=O)N1CCC(CC(=O)N(c2ccccc2)C2CCCC(F)(F)C2)(C(=O)O)CC1)c1ccc(F)cc1 | 10.1021/acsmedchemlett.4c00046 | |||
| 170355416 | 196101 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 495 | 6 | 1 | 3 | 5.3 | CN(C(=O)N1CCC(CC(=O)N(c2ccccc2)C2CCCCC2)(C(=O)O)CC1)c1cccc(F)c1 | 10.1021/acsmedchemlett.4c00046 | |||
| CHEMBL5416925 | 196101 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 495 | 6 | 1 | 3 | 5.3 | CN(C(=O)N1CCC(CC(=O)N(c2ccccc2)C2CCCCC2)(C(=O)O)CC1)c1cccc(F)c1 | 10.1021/acsmedchemlett.4c00046 | |||
| 170355432 | 195312 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 531 | 6 | 1 | 3 | 5.6 | CN(C(=O)N1CCC(CC(=O)N(c2cccc(F)c2)C2CCCC(F)(F)C2)(C(=O)O)CC1)c1ccccc1 | 10.1021/acsmedchemlett.4c00046 | |||
| CHEMBL5400661 | 195312 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 531 | 6 | 1 | 3 | 5.6 | CN(C(=O)N1CCC(CC(=O)N(c2cccc(F)c2)C2CCCC(F)(F)C2)(C(=O)O)CC1)c1ccccc1 | 10.1021/acsmedchemlett.4c00046 | |||
| 170355507 | 195675 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 507 | 6 | 1 | 3 | 5.4 | CN(C(=O)N1CCC(CC(=O)N(c2ccccc2)c2ccccc2F)(C(=O)O)CC1)c1ccc(F)cc1 | 10.1021/acsmedchemlett.4c00046 | |||
| CHEMBL5408779 | 195675 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 507 | 6 | 1 | 3 | 5.4 | CN(C(=O)N1CCC(CC(=O)N(c2ccccc2)c2ccccc2F)(C(=O)O)CC1)c1ccc(F)cc1 | 10.1021/acsmedchemlett.4c00046 | |||
| 170355534 | 196708 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 489 | 6 | 1 | 3 | 5.3 | CN(C(=O)N1CCC(CC(=O)N(c2ccccc2)c2ccccc2)(C(=O)O)CC1)c1ccc(F)cc1 | 10.1021/acsmedchemlett.4c00046 | |||
| CHEMBL5430412 | 196708 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 489 | 6 | 1 | 3 | 5.3 | CN(C(=O)N1CCC(CC(=O)N(c2ccccc2)c2ccccc2)(C(=O)O)CC1)c1ccc(F)cc1 | 10.1021/acsmedchemlett.4c00046 | |||
| CHEMBL938 | 218397 | None | 23 | Human | Binding | pKi | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/ml500278g | |||||
| CHEMBL938 | 218397 | None | 23 | Human | Binding | pKi | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmcl.2015.10.084 | |||||
| 170355525 | 196704 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 495 | 6 | 1 | 3 | 5.3 | CN(C(=O)N1CCC(CC(=O)N(c2ccccc2)C2CCCCC2)(C(=O)O)CC1)c1ccc(F)cc1 | 10.1021/acsmedchemlett.4c00046 | |||
| CHEMBL5430333 | 196704 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 495 | 6 | 1 | 3 | 5.3 | CN(C(=O)N1CCC(CC(=O)N(c2ccccc2)C2CCCCC2)(C(=O)O)CC1)c1ccc(F)cc1 | 10.1021/acsmedchemlett.4c00046 | |||
| 6918 | 1028 | None | 34 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2010.03.064 | |||
| 9804984 | 1028 | None | 34 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2010.03.064 | |||
| CHEMBL189568 | 1028 | None | 34 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2010.03.064 | |||
| 6918 | 1028 | None | 34 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/acs.jmedchem.8b00294 | |||
| 6918 | 1028 | None | 34 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/ml500278g | |||
| 9804984 | 1028 | None | 34 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/acs.jmedchem.8b00294 | |||
| 9804984 | 1028 | None | 34 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/ml500278g | |||
| CHEMBL189568 | 1028 | None | 34 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/acs.jmedchem.8b00294 | |||
| CHEMBL189568 | 1028 | None | 34 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/ml500278g | |||
| 6918 | 1028 | None | 34 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmcl.2015.10.084 | |||
| 9804984 | 1028 | None | 34 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmcl.2015.10.084 | |||
| CHEMBL189568 | 1028 | None | 34 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmcl.2015.10.084 | |||
| 6918 | 1028 | None | 34 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/jm049715t | |||
| 9804984 | 1028 | None | 34 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/jm049715t | |||
| CHEMBL189568 | 1028 | None | 34 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/jm049715t | |||
| 11317806 | 123709 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 489 | 10 | 1 | 7 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2C)cc1 | 10.1021/jm049715t | |||
| CHEMBL361927 | 123709 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 489 | 10 | 1 | 7 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2C)cc1 | 10.1021/jm049715t | |||
| 11994291 | 80759 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 485 | 12 | 1 | 7 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(OCCCC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| CHEMBL215160 | 80759 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 485 | 12 | 1 | 7 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(OCCCC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| 11994289 | 82509 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 2 | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| CHEMBL217673 | 82509 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 2 | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| 16133225 | 419 | None | 38 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm051222g | |||||
| 172198 | 419 | None | 38 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm051222g | |||||
| 172198.0 | 419 | None | 38 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm051222g | |||||
| 2504 | 419 | None | 38 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm051222g | |||||
| 45266664 | 419 | None | 38 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm051222g | |||||
| 5272 | 419 | None | 38 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm051222g | |||||
| CHEMBL408403 | 419 | None | 38 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm051222g | |||||
| DB11842 | 419 | None | 38 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm051222g | |||||
| CHEMBL404996 | 214999 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | CCSC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm030921v | |||||
| CHEMBL3350599 | 213940 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](N)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm050280z | |||||
| 11994289 | 82509 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 2 | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/acs.jmedchem.5b00982 | |||
| CHEMBL217673 | 82509 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 2 | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/acs.jmedchem.5b00982 | |||
| 11994289 | 82509 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 2 | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmcl.2015.10.084 | |||
| CHEMBL217673 | 82509 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 2 | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmcl.2015.10.084 | |||
| CHEMBL268815 | 213225 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm051222g | |||||
| 10463891 | 96967 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1093 | 26 | 13 | 14 | -0.6 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 | 10.1021/jm0491492 | |||
| CHEMBL265881 | 96967 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 1093 | 26 | 13 | 14 | -0.6 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 | 10.1021/jm0491492 | |||
| CHEMBL268815 | 213225 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm0491492 | |||||
| CHEMBL424755 | 215785 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)O | 10.1021/jm0613469 | |||||
| 44398242 | 67237 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 599 | 11 | 6 | 8 | -0.2 | CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 | 10.1021/jm049651m | |||
| CHEMBL187880 | 67237 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 599 | 11 | 6 | 8 | -0.2 | CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 | 10.1021/jm049651m | |||
| 10163396 | 81609 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 489 | 12 | 1 | 7 | 4.5 | CCCCOCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| CHEMBL216250 | 81609 | None | 0 | Human | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 489 | 12 | 1 | 7 | 4.5 | CCCCOCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| 171345055 | 194439 | None | 0 | Rat | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 1073 | 26 | 13 | 14 | -1.2 | CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@]1(Cc2ccc(O)cc2)CC(=O)N2[C@H]1SC[C@H]2C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2022.128983 | |||
| CHEMBL5286105 | 194439 | None | 0 | Rat | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 1073 | 26 | 13 | 14 | -1.2 | CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@]1(Cc2ccc(O)cc2)CC(=O)N2[C@H]1SC[C@H]2C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2022.128983 | |||
| 168283461 | 191092 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 462 | 10 | 1 | 8 | 4.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5186237 | 191092 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 462 | 10 | 1 | 8 | 4.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 16133225 | 419 | None | 38 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm049651m | |||||
| 172198 | 419 | None | 38 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm049651m | |||||
| 172198.0 | 419 | None | 38 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm049651m | |||||
| 2504 | 419 | None | 38 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm049651m | |||||
| 45266664 | 419 | None | 38 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm049651m | |||||
| 5272 | 419 | None | 38 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm049651m | |||||
| CHEMBL408403 | 419 | None | 38 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm049651m | |||||
| DB11842 | 419 | None | 38 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 4 | ChEMBL | None | None | None | None | 10.1021/jm049651m | |||||
| 171356731 | 193903 | None | 0 | Rat | Binding | pKi | = | 8.9 | 8.9 | -1 | 2 | ChEMBL | 1060 | 30 | 14 | 13 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2022.128983 | |||
| CHEMBL5274111 | 193903 | None | 0 | Rat | Binding | pKi | = | 8.9 | 8.9 | -1 | 2 | ChEMBL | 1060 | 30 | 14 | 13 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2022.128983 | |||
| 168273584 | 190322 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 503 | 8 | 1 | 10 | 4.2 | CCCc1nc(-c2ccc(Cn3ccnc3-c3nccs3)cc2)c(S(=O)(=O)NC(=O)OC)s1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5174659 | 190322 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 503 | 8 | 1 | 10 | 4.2 | CCCc1nc(-c2ccc(Cn3ccnc3-c3nccs3)cc2)c(S(=O)(=O)NC(=O)OC)s1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL268815 | 213225 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm049651m | |||||
| 9850834 | 154752 | None | 20 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/acs.jmedchem.5b00982 | |||
| CHEMBL39959 | 154752 | None | 20 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/acs.jmedchem.5b00982 | |||
| 16087342 | 141800 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1149 | 28 | 13 | 14 | 0.8 | CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1021/jm051222g | |||
| CHEMBL385706 | 141800 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1149 | 28 | 13 | 14 | 0.8 | CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1021/jm051222g | |||
| 11564291 | 167190 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1008 | 26 | 12 | 12 | -0.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | |||
| CHEMBL428986 | 167190 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 1008 | 26 | 12 | 12 | -0.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | |||
| 10160913 | 141894 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 447 | 8 | 1 | 7 | 4.3 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| CHEMBL386269 | 141894 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 447 | 8 | 1 | 7 | 4.3 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| 11766283 | 71604 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 909 | 23 | 11 | 11 | -0.2 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | |||
| CHEMBL196316 | 71604 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 909 | 23 | 11 | 11 | -0.2 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | |||
| 168270996 | 190168 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 64 | 2 | ChEMBL | 533 | 11 | 1 | 6 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5172324 | 190168 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 64 | 2 | ChEMBL | 533 | 11 | 1 | 6 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 168291545 | 192099 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 597 | 10 | 1 | 6 | 7.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1cc(F)c(Cn2c(C(C)(C)C)nc3ccccc32)c(F)c1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5201369 | 192099 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 597 | 10 | 1 | 6 | 7.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1cc(F)c(Cn2c(C(C)(C)C)nc3ccccc32)c(F)c1 | 10.1016/j.bmc.2022.116804 | |||
| 162660565 | 181428 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 501 | 9 | 1 | 8 | 4.6 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 | 10.1016/j.bmc.2020.115859 | |||
| CHEMBL4762752 | 181428 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 501 | 9 | 1 | 8 | 4.6 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 | 10.1016/j.bmc.2020.115859 | |||
| CHEMBL426885 | 215812 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)O | 10.1021/jm0613469 | |||||
| 56657702 | 63273 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 1050 | 25 | 12 | 13 | 0.7 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm0491492 | |||
| CHEMBL1791309 | 63273 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 1050 | 25 | 12 | 13 | 0.7 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm0491492 | |||
| 168290795 | 192056 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 33 | 2 | ChEMBL | 559 | 11 | 1 | 6 | 7.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5200734 | 192056 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 33 | 2 | ChEMBL | 559 | 11 | 1 | 6 | 7.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 168292515 | 192148 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 651 | 10 | 1 | 6 | 8.0 | CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2cc(F)c(Cn3c(C(C)(C)C)nc4ccccc43)c(F)c2)c1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5202149 | 192148 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 651 | 10 | 1 | 6 | 8.0 | CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2cc(F)c(Cn3c(C(C)(C)C)nc4ccccc43)c(F)c2)c1 | 10.1016/j.bmc.2022.116804 | |||
| 118725967 | 117262 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1021/acs.jmedchem.5b00982 | |||
| CHEMBL3394207 | 117262 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1021/acs.jmedchem.5b00982 | |||
| 118725967 | 117262 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2015.10.084 | |||
| CHEMBL3394207 | 117262 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2015.10.084 | |||
| 168274956 | 190447 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 573 | 10 | 1 | 6 | 6.9 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(F)(F)F)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5176607 | 190447 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 573 | 10 | 1 | 6 | 6.9 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(F)(F)F)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 10227337 | 81687 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 474 | 10 | 2 | 6 | 4.6 | CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| CHEMBL216361 | 81687 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 474 | 10 | 2 | 6 | 4.6 | CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| 168296606 | 192557 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 587 | 11 | 1 | 6 | 8.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5208437 | 192557 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 587 | 11 | 1 | 6 | 8.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 145963801 | 164156 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 475 | 9 | 1 | 7 | 4.9 | CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL4209214 | 164156 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 475 | 9 | 1 | 7 | 4.9 | CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| 11365721 | 98720 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 640 | 13 | 1 | 10 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 | 10.1021/jm031031i | |||
| CHEMBL277388 | 98720 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 640 | 13 | 1 | 10 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 | 10.1021/jm031031i | |||
| 168287840 | 191415 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 32 | 2 | ChEMBL | 547 | 12 | 1 | 6 | 6.9 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5191241 | 191415 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 32 | 2 | ChEMBL | 547 | 12 | 1 | 6 | 6.9 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 145978135 | 163984 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 473 | 9 | 1 | 7 | 4.7 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCC2CC2)s1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL4207027 | 163984 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 473 | 9 | 1 | 7 | 4.7 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCC2CC2)s1 | 10.1016/j.bmcl.2017.11.042 | |||
| 168295859 | 192394 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -50 | 2 | ChEMBL | 569 | 11 | 1 | 9 | 6.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5205969 | 192394 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -50 | 2 | ChEMBL | 569 | 11 | 1 | 9 | 6.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 168288075 | 191771 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 595 | 12 | 1 | 6 | 7.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(Cc3ccccc3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5196244 | 191771 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 595 | 12 | 1 | 6 | 7.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(Cc3ccccc3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 11994292 | 82017 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 471 | 10 | 1 | 7 | 4.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(OC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| CHEMBL216515 | 82017 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 471 | 10 | 1 | 7 | 4.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(OC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| 168285844 | 191678 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 462 | 8 | 1 | 8 | 4.2 | CCCc1nc(-c2ccc(Cn3ccnc3C(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5194914 | 191678 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 462 | 8 | 1 | 8 | 4.2 | CCCc1nc(-c2ccc(Cn3ccnc3C(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 | 10.1016/j.bmc.2022.116790 | |||
| 44420775 | 137971 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 315 | 7 | 2 | 4 | 2.2 | CC[C@@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O | 10.1021/jm0613469 | |||
| CHEMBL376286 | 137971 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 315 | 7 | 2 | 4 | 2.2 | CC[C@@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O | 10.1021/jm0613469 | |||
| 145965121 | 164521 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 461 | 8 | 1 | 7 | 4.7 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)C)s1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL4213607 | 164521 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 461 | 8 | 1 | 7 | 4.7 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)C)s1 | 10.1016/j.bmcl.2017.11.042 | |||
| 11296725 | 100428 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 652 | 13 | 2 | 9 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(C)=O)cc3c2=O)cc1 | 10.1021/jm031031i | |||
| CHEMBL289803 | 100428 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 652 | 13 | 2 | 9 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(C)=O)cc3c2=O)cc1 | 10.1021/jm031031i | |||
| 9830680 | 100697 | None | 0 | Rat | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm990504b | |||
| CHEMBL292150 | 100697 | None | 0 | Rat | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm990504b | |||
| 162657895 | 181165 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 545 | 12 | 1 | 8 | 6.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)C)c1 | 10.1016/j.bmc.2020.115859 | |||
| CHEMBL4759641 | 181165 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 545 | 12 | 1 | 8 | 6.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)C)c1 | 10.1016/j.bmc.2020.115859 | |||
| 56964910 | 77473 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1021/ml500278g | |||
| CHEMBL2086892 | 77473 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1021/ml500278g | |||
| 56964910 | 77473 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2015.10.084 | |||
| CHEMBL2086892 | 77473 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2015.10.084 | |||
| 162675267 | 183463 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 501 | 8 | 1 | 7 | 4.8 | CC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 | 10.1016/j.bmc.2020.115859 | |||
| CHEMBL4797684 | 183463 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 501 | 8 | 1 | 7 | 4.8 | CC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 | 10.1016/j.bmc.2020.115859 | |||
| 11764788 | 100912 | None | 0 | Rat | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm990504b | |||
| CHEMBL293501 | 100912 | None | 0 | Rat | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm990504b | |||
| 158303357 | 192341 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 532 | 10 | 1 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5205106 | 192341 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 532 | 10 | 1 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 166492461 | 191921 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 474 | 8 | 1 | 8 | 4.2 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5198482 | 191921 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 474 | 8 | 1 | 8 | 4.2 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 145977406 | 163943 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 487 | 8 | 1 | 7 | 5.2 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC2CCCC2)s1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL4206507 | 163943 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 487 | 8 | 1 | 7 | 5.2 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC2CCCC2)s1 | 10.1016/j.bmcl.2017.11.042 | |||
| 73213176 | 104757 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | - | 1 | ChEMBL | 454 | 9 | 2 | 6 | 2.6 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2013.12.040 | |||
| CHEMBL3105392 | 104757 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | - | 1 | ChEMBL | 454 | 9 | 2 | 6 | 2.6 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2013.12.040 | |||
| 11995658 | 82169 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 364 | 6 | 1 | 6 | 4.0 | CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(-c2nn[nH]n2)s1 | 10.1021/jm0606185 | |||
| CHEMBL216746 | 82169 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 364 | 6 | 1 | 6 | 4.0 | CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(-c2nn[nH]n2)s1 | 10.1021/jm0606185 | |||
| 168274734 | 190775 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | - | 1 | ChEMBL | 561 | 12 | 1 | 6 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC(C)C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5181652 | 190775 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | - | 1 | ChEMBL | 561 | 12 | 1 | 6 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC(C)C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 166492455 | 191518 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 476 | 7 | 1 | 8 | 4.4 | CCCc1nc(-c2ccc(Cn3ccnc3C(C)(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5192639 | 191518 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 476 | 7 | 1 | 8 | 4.4 | CCCc1nc(-c2ccc(Cn3ccnc3C(C)(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 | 10.1016/j.bmc.2022.116790 | |||
| 3936 | 2210 | None | 32 | Human | Binding | pKi | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| 6603900 | 2210 | None | 32 | Human | Binding | pKi | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL288174 | 2210 | None | 32 | Human | Binding | pKi | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| 11994290 | 80431 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 441 | 9 | 1 | 6 | 4.4 | CCCCc1ccc(S(=O)(=O)NC(=O)OCC)c(-c2ccc(Cn3ccnc3)cc2)c1 | 10.1021/jm0606185 | |||
| CHEMBL214525 | 80431 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 441 | 9 | 1 | 6 | 4.4 | CCCCc1ccc(S(=O)(=O)NC(=O)OCC)c(-c2ccc(Cn3ccnc3)cc2)c1 | 10.1021/jm0606185 | |||
| CHEMBL268815 | 213225 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm030921v | |||||
| 10031067 | 100406 | None | 4 | Human | Binding | pKi | = | 8.7 | 8.7 | -2 | 3 | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/acs.jmedchem.5b00982 | |||
| CHEMBL289614 | 100406 | None | 4 | Human | Binding | pKi | = | 8.7 | 8.7 | -2 | 3 | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/acs.jmedchem.5b00982 | |||
| CHEMBL216331 | 211782 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CCS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCS)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm049651m | |||||
| 56657702 | 63273 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 1050 | 25 | 12 | 13 | 0.7 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm0491492 | |||
| CHEMBL1791309 | 63273 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 1050 | 25 | 12 | 13 | 0.7 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm0491492 | |||
| 168277309 | 190337 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 448 | 8 | 1 | 8 | 3.7 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5174923 | 190337 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 448 | 8 | 1 | 8 | 3.7 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 3936 | 2210 | None | 32 | Human | Binding | pKi | = | 8.6 | 8.6 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm031031i | |||
| 6603900 | 2210 | None | 32 | Human | Binding | pKi | = | 8.6 | 8.6 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm031031i | |||
| CHEMBL288174 | 2210 | None | 32 | Human | Binding | pKi | = | 8.6 | 8.6 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm031031i | |||
| 44400670 | 158984 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 993 | 23 | 12 | 13 | -0.7 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 | 10.1021/jm0491492 | |||
| CHEMBL409528 | 158984 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 993 | 23 | 12 | 13 | -0.7 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 | 10.1021/jm0491492 | |||
| 3936 | 2210 | None | 32 | Human | Binding | pKi | = | 8.6 | 8.6 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm049715t | |||
| 6603900 | 2210 | None | 32 | Human | Binding | pKi | = | 8.6 | 8.6 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm049715t | |||
| CHEMBL288174 | 2210 | None | 32 | Human | Binding | pKi | = | 8.6 | 8.6 | -2 | 4 | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm049715t | |||
| 168277868 | 190586 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 476 | 10 | 1 | 8 | 4.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5178914 | 190586 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 476 | 10 | 1 | 8 | 4.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 145978497 | 163749 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 489 | 10 | 1 | 7 | 5.3 | CC(C)CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL4204342 | 163749 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 489 | 10 | 1 | 7 | 5.3 | CC(C)CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| 145972310 | 164662 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 474 | 9 | 1 | 6 | 4.6 | CCN(CC)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL4215292 | 164662 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 474 | 9 | 1 | 6 | 4.6 | CCN(CC)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| 45102601 | 169674 | None | 13 | Human | Binding | pKi | = | 5.6 | 5.6 | -1995 | 2 | ChEMBL | 527 | 12 | 3 | 6 | 5.4 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4435800 | 169674 | None | 13 | Human | Binding | pKi | = | 5.6 | 5.6 | -1995 | 2 | ChEMBL | 527 | 12 | 3 | 6 | 5.4 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| 162651258 | 180441 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 545 | 13 | 1 | 8 | 5.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCC)c1 | 10.1016/j.bmc.2020.115859 | |||
| CHEMBL4751226 | 180441 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 545 | 13 | 1 | 8 | 5.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCC)c1 | 10.1016/j.bmc.2020.115859 | |||
| 166492466 | 192051 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 476 | 8 | 1 | 8 | 4.4 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5200682 | 192051 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 476 | 8 | 1 | 8 | 4.4 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 56964910 | 77473 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmc.2020.115859 | |||
| CHEMBL2086892 | 77473 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmc.2020.115859 | |||
| 56964910 | 77473 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL2086892 | 77473 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| 145967796 | 164928 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 475 | 7 | 1 | 7 | 5.1 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL4218765 | 164928 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 475 | 7 | 1 | 7 | 5.1 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 | 10.1016/j.bmcl.2017.11.042 | |||
| 67132863 | 77476 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 503 | 11 | 1 | 8 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2)c1 | 10.1016/j.bmc.2020.115859 | |||
| CHEMBL2086910 | 77476 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 503 | 11 | 1 | 8 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2)c1 | 10.1016/j.bmc.2020.115859 | |||
| 145976243 | 163621 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 473 | 11 | 1 | 6 | 5.2 | CCCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL4202730 | 163621 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 473 | 11 | 1 | 6 | 5.2 | CCCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| 163408877 | 190808 | None | 3 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 490 | 7 | 1 | 8 | 4.6 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5182186 | 190808 | None | 3 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 490 | 7 | 1 | 8 | 4.6 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 168277087 | 190595 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 505 | 10 | 1 | 6 | 5.9 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2cnc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5179052 | 190595 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 505 | 10 | 1 | 6 | 5.9 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2cnc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 145969149 | 164864 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 461 | 9 | 1 | 7 | 4.7 | CCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL4217991 | 164864 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 461 | 9 | 1 | 7 | 4.7 | CCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| 73213178 | 104758 | None | 0 | Human | Binding | pKi | = | 4.5 | 4.5 | - | 1 | ChEMBL | 483 | 10 | 3 | 6 | 2.4 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2013.12.040 | |||
| CHEMBL3105394 | 104758 | None | 0 | Human | Binding | pKi | = | 4.5 | 4.5 | - | 1 | ChEMBL | 483 | 10 | 3 | 6 | 2.4 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2013.12.040 | |||
| 10057017 | 161921 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1093 | 26 | 13 | 14 | -0.6 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 | 10.1021/jm030921v | |||
| CHEMBL414478 | 161921 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1093 | 26 | 13 | 14 | -0.6 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 | 10.1021/jm030921v | |||
| 10057017 | 161921 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1093 | 26 | 13 | 14 | -0.6 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 | 10.1021/jm0491492 | |||
| CHEMBL414478 | 161921 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1093 | 26 | 13 | 14 | -0.6 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 | 10.1021/jm0491492 | |||
| 168272246 | 190601 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 477 | 10 | 1 | 8 | 4.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cc2ncco2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5179119 | 190601 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 477 | 10 | 1 | 8 | 4.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cc2ncco2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 10196520 | 67665 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 553 | 11 | 1 | 7 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 | 10.1021/jm049715t | |||
| CHEMBL190577 | 67665 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 553 | 11 | 1 | 7 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 | 10.1021/jm049715t | |||
| 6918 | 1028 | None | 34 | Human | Binding | pKi | = | 8.4 | 8.4 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2022.116804 | |||
| 9804984 | 1028 | None | 34 | Human | Binding | pKi | = | 8.4 | 8.4 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL189568 | 1028 | None | 34 | Human | Binding | pKi | = | 8.4 | 8.4 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2022.116804 | |||
| 44398381 | 67627 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 599 | 11 | 6 | 8 | -0.2 | CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 | 10.1021/jm049651m | |||
| CHEMBL190286 | 67627 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 599 | 11 | 6 | 8 | -0.2 | CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 | 10.1021/jm049651m | |||
| 171346204 | 194463 | None | 0 | Rat | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 1073 | 26 | 13 | 14 | -1.2 | CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@]1(Cc2ccc(O)cc2)CC(=O)N2[C@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)CS[C@@H]21 | 10.1016/j.bmcl.2022.128983 | |||
| CHEMBL5286767 | 194463 | None | 0 | Rat | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 1073 | 26 | 13 | 14 | -1.2 | CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@]1(Cc2ccc(O)cc2)CC(=O)N2[C@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)CS[C@@H]21 | 10.1016/j.bmcl.2022.128983 | |||
| 10054827 | 164233 | None | 0 | Rat | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 634 | 11 | 1 | 8 | 6.8 | CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| CHEMBL42101 | 164233 | None | 0 | Rat | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 634 | 11 | 1 | 8 | 6.8 | CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| 145978684 | 163656 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 445 | 9 | 1 | 6 | 4.5 | CCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL4203099 | 163656 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 445 | 9 | 1 | 6 | 4.5 | CCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| 145974498 | 164821 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 447 | 8 | 1 | 7 | 4.3 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL4217484 | 164821 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 447 | 8 | 1 | 7 | 4.3 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| 168287782 | 191933 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | 22 | 2 | ChEMBL | 545 | 11 | 1 | 6 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5198739 | 191933 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | 22 | 2 | ChEMBL | 545 | 11 | 1 | 6 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 10277322 | 141875 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 477 | 10 | 1 | 8 | 3.9 | COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| CHEMBL386172 | 141875 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 477 | 10 | 1 | 8 | 3.9 | COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| 11274375 | 100516 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 804 | 16 | 1 | 9 | 9.4 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1021/jm031031i | |||
| CHEMBL290708 | 100516 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 804 | 16 | 1 | 9 | 9.4 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1021/jm031031i | |||
| 163409135 | 190292 | None | 3 | Human | Binding | pKi | = | 6.5 | 6.5 | -37 | 2 | ChEMBL | 623 | 11 | 1 | 9 | 6.5 | CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5174180 | 190292 | None | 3 | Human | Binding | pKi | = | 6.5 | 6.5 | -37 | 2 | ChEMBL | 623 | 11 | 1 | 9 | 6.5 | CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 | 10.1016/j.bmc.2022.116790 | |||
| 11216369 | 100425 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 742 | 15 | 1 | 9 | 8.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1021/jm031031i | |||
| CHEMBL289775 | 100425 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 742 | 15 | 1 | 9 | 8.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1021/jm031031i | |||
| 11994293 | 82333 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 459 | 10 | 1 | 6 | 4.9 | CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| CHEMBL217208 | 82333 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 459 | 10 | 1 | 6 | 4.9 | CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| 145976532 | 163701 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 443 | 8 | 1 | 6 | 4.1 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)C2CC2)s1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL4203624 | 163701 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 443 | 8 | 1 | 6 | 4.1 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)C2CC2)s1 | 10.1016/j.bmcl.2017.11.042 | |||
| 168279676 | 191238 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | 11 | 2 | ChEMBL | 573 | 11 | 1 | 6 | 7.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5188126 | 191238 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | 11 | 2 | ChEMBL | 573 | 11 | 1 | 6 | 7.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 166492421 | 190734 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 545 | 11 | 1 | 10 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5181087 | 190734 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 545 | 11 | 1 | 10 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 10116410 | 141606 | None | 1 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 475 | 9 | 1 | 7 | 4.9 | CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| CHEMBL384577 | 141606 | None | 1 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 475 | 9 | 1 | 7 | 4.9 | CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| 11445913 | 133691 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 908 | 19 | 10 | 12 | 0.3 | C[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 | 10.1021/jm0491492 | |||
| CHEMBL371395 | 133691 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 908 | 19 | 10 | 12 | 0.3 | C[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 | 10.1021/jm0491492 | |||
| 16124929 | 83478 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 349 | 7 | 2 | 4 | 2.4 | O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cn2ccnc2)c1 | 10.1021/jm0613469 | |||
| CHEMBL219840 | 83478 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 349 | 7 | 2 | 4 | 2.4 | O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cn2ccnc2)c1 | 10.1021/jm0613469 | |||
| 166492441 | 191614 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 504 | 11 | 1 | 8 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5193845 | 191614 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 504 | 11 | 1 | 8 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 162666037 | 182418 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 559 | 14 | 1 | 8 | 6.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCCC)c1 | 10.1016/j.bmc.2020.115859 | |||
| CHEMBL4784233 | 182418 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 559 | 14 | 1 | 8 | 6.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCCC)c1 | 10.1016/j.bmc.2020.115859 | |||
| 8374 | 2922 | None | 43 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/j.bmcl.2015.10.084 | |||
| 9937291 | 2922 | None | 43 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/j.bmcl.2015.10.084 | |||
| CHEMBL34124 | 2922 | None | 43 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/j.bmcl.2015.10.084 | |||
| DB16266 | 2922 | None | 43 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/j.bmcl.2015.10.084 | |||
| 145964638 | 164478 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 489 | 11 | 1 | 7 | 5.5 | CCCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL4213069 | 164478 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 489 | 11 | 1 | 7 | 5.5 | CCCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| 168274602 | 190485 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | 97 | 2 | ChEMBL | 547 | 11 | 1 | 6 | 7.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5177359 | 190485 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | 97 | 2 | ChEMBL | 547 | 11 | 1 | 6 | 7.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 9806878 | 127587 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 525 | 10 | 1 | 7 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3ccccc32)cc1 | 10.1021/jm049715t | |||
| CHEMBL366210 | 127587 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 525 | 10 | 1 | 7 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3ccccc32)cc1 | 10.1021/jm049715t | |||
| 11995655 | 141584 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 488 | 10 | 1 | 6 | 5.0 | CCCCN(C)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| CHEMBL384462 | 141584 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 488 | 10 | 1 | 6 | 5.0 | CCCCN(C)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| 44212339 | 207494 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 438 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccccc2[n+]([O-])c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL77029 | 207494 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 438 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccccc2[n+]([O-])c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 168297670 | 192487 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 615 | 10 | 1 | 6 | 7.8 | CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5207511 | 192487 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 615 | 10 | 1 | 6 | 7.8 | CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 | 10.1016/j.bmc.2022.116804 | |||
| 11181498 | 100563 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 680 | 14 | 1 | 9 | 6.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(C)=O)cc3c2=O)cc1 | 10.1021/jm031031i | |||
| CHEMBL291124 | 100563 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 680 | 14 | 1 | 9 | 6.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(C)=O)cc3c2=O)cc1 | 10.1021/jm031031i | |||
| 16087341 | 96934 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1050 | 25 | 12 | 13 | 0.7 | CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1021/jm051222g | |||
| CHEMBL265613 | 96934 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1050 | 25 | 12 | 13 | 0.7 | CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1021/jm051222g | |||
| 16124928 | 83477 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 349 | 7 | 3 | 3 | 2.4 | O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cc2cnc[nH]2)c1 | 10.1021/jm0613469 | |||
| CHEMBL219839 | 83477 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 349 | 7 | 3 | 3 | 2.4 | O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cc2cnc[nH]2)c1 | 10.1021/jm0613469 | |||
| 11180576 | 100366 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 566 | 11 | 1 | 7 | 6.6 | CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm031031i | |||
| CHEMBL289306 | 100366 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 566 | 11 | 1 | 7 | 6.6 | CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm031031i | |||
| 145972980 | 164589 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 433 | 7 | 1 | 7 | 3.9 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL4214477 | 164589 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 433 | 7 | 1 | 7 | 3.9 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| 145972801 | 164697 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 474 | 10 | 2 | 6 | 4.6 | CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL4215828 | 164697 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 474 | 10 | 2 | 6 | 4.6 | CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| 166492420 | 192367 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 559 | 11 | 1 | 10 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5205556 | 192367 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 559 | 11 | 1 | 10 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 11722069 | 70591 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 895 | 22 | 11 | 11 | 0.1 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | |||
| CHEMBL194864 | 70591 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 895 | 22 | 11 | 11 | 0.1 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | |||
| 73213175 | 104756 | None | 0 | Human | Binding | pKi | = | 4.4 | 4.4 | - | 1 | ChEMBL | 397 | 8 | 2 | 6 | 3.2 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)Nc1nccs1 | 10.1016/j.bmcl.2013.12.040 | |||
| CHEMBL3105391 | 104756 | None | 0 | Human | Binding | pKi | = | 4.4 | 4.4 | - | 1 | ChEMBL | 397 | 8 | 2 | 6 | 3.2 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)Nc1nccs1 | 10.1016/j.bmcl.2013.12.040 | |||
| 166492452 | 190884 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 502 | 11 | 1 | 8 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5183386 | 190884 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 502 | 11 | 1 | 8 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 145966800 | 164121 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 475 | 9 | 1 | 7 | 5.1 | CCC(C)OC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL4208670 | 164121 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 475 | 9 | 1 | 7 | 5.1 | CCC(C)OC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| 11366289 | 168116 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 784 | 18 | 1 | 9 | 9.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)CCCC)cc3c2=O)cc1 | 10.1021/jm031031i | |||
| CHEMBL432095 | 168116 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 784 | 18 | 1 | 9 | 9.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)CCCC)cc3c2=O)cc1 | 10.1021/jm031031i | |||
| 168283187 | 191326 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 639 | 11 | 1 | 6 | 8.4 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C34CC5CC(CC(C5)C3)C4)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5189691 | 191326 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 639 | 11 | 1 | 6 | 8.4 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C34CC5CC(CC(C5)C3)C4)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 10396262 | 115498 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 1022 | 27 | 12 | 12 | 0.3 | CC[C@H](C)[C@H](NC(=O)c1cc(CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc(Cc2ccc(O)cc2)c1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm050280z | |||
| CHEMBL3350600 | 115498 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 1022 | 27 | 12 | 12 | 0.3 | CC[C@H](C)[C@H](NC(=O)c1cc(CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc(Cc2ccc(O)cc2)c1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm050280z | |||
| 16125001 | 106487 | None | 0 | Human | Binding | pKi | = | 4.3 | 4.3 | - | 1 | ChEMBL | 315 | 7 | 2 | 4 | 2.2 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O | 10.1016/j.bmcl.2013.12.040 | |||
| CHEMBL3105395 | 106487 | None | 0 | Human | Binding | pKi | = | 4.3 | 4.3 | - | 1 | ChEMBL | 315 | 7 | 2 | 4 | 2.2 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O | 10.1016/j.bmcl.2013.12.040 | |||
| CHEMBL3139603 | 106487 | None | 0 | Human | Binding | pKi | = | 4.3 | 4.3 | - | 1 | ChEMBL | 315 | 7 | 2 | 4 | 2.2 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O | 10.1016/j.bmcl.2013.12.040 | |||
| 11331641 | 100356 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 742 | 15 | 1 | 9 | 8.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(C)=O)cc3c2=O)cc1 | 10.1021/jm031031i | |||
| CHEMBL289211 | 100356 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 742 | 15 | 1 | 9 | 8.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(C)=O)cc3c2=O)cc1 | 10.1021/jm031031i | |||
| 67133138 | 77477 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 531 | 12 | 1 | 8 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CC)c1 | 10.1016/j.bmc.2020.115859 | |||
| CHEMBL2086911 | 77477 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 531 | 12 | 1 | 8 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CC)c1 | 10.1016/j.bmc.2020.115859 | |||
| 10742620 | 57619 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | -16 | 2 | ChEMBL | 460 | 7 | 2 | 6 | 5.1 | CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1668003 | 57619 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | -16 | 2 | ChEMBL | 460 | 7 | 2 | 6 | 5.1 | CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 163409136 | 191011 | None | 3 | Human | Binding | pKi | = | 6.3 | 6.3 | -18 | 2 | ChEMBL | 583 | 11 | 1 | 9 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5185088 | 191011 | None | 3 | Human | Binding | pKi | = | 6.3 | 6.3 | -18 | 2 | ChEMBL | 583 | 11 | 1 | 9 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 145965943 | 164299 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 477 | 10 | 1 | 8 | 3.9 | COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL4210874 | 164299 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 477 | 10 | 1 | 8 | 3.9 | COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | |||
| 131590 | 20710 | None | 37 | Human | Binding | pKi | = | 6.3 | 6.3 | -16 | 3 | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm9504722 | |||
| CHEMBL130896 | 20710 | None | 37 | Human | Binding | pKi | = | 6.3 | 6.3 | -16 | 3 | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm9504722 | |||
| 10276878 | 80453 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 469 | 11 | 1 | 6 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| CHEMBL214592 | 80453 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 469 | 11 | 1 | 6 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| 10140383 | 82422 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 475 | 11 | 1 | 7 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| CHEMBL217249 | 82422 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 475 | 11 | 1 | 7 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| 168271055 | 190047 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 588 | 11 | 1 | 8 | 7.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3nccs3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5170220 | 190047 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 588 | 11 | 1 | 8 | 7.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3nccs3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 168272577 | 190464 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 561 | 10 | 1 | 6 | 7.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)(C)C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5176951 | 190464 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 561 | 10 | 1 | 6 | 7.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)(C)C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 168277414 | 190572 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 517 | 8 | 1 | 10 | 4.4 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5178751 | 190572 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 517 | 8 | 1 | 10 | 4.4 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 166492465 | 190656 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 518 | 11 | 1 | 8 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5179875 | 190656 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 518 | 11 | 1 | 8 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 162650706 | 180144 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 515 | 10 | 1 | 8 | 5.0 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 | 10.1016/j.bmc.2020.115859 | |||
| CHEMBL4747530 | 180144 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 515 | 10 | 1 | 8 | 5.0 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 | 10.1016/j.bmc.2020.115859 | |||
| 16087340 | 166032 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 912 | 21 | 10 | 11 | 1.2 | CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1021/jm051222g | |||
| CHEMBL425077 | 166032 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 912 | 21 | 10 | 11 | 1.2 | CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1021/jm051222g | |||
| 168292360 | 191986 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 581 | 11 | 1 | 6 | 7.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3ccccc3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5199606 | 191986 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 581 | 11 | 1 | 6 | 7.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3ccccc3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 168278021 | 190302 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 651 | 10 | 1 | 6 | 8.0 | CCCc1ccc(S(=O)(=O)NC(=O)OCCC(F)(F)C(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5174301 | 190302 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 651 | 10 | 1 | 6 | 8.0 | CCCc1ccc(S(=O)(=O)NC(=O)OCCC(F)(F)C(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 | 10.1016/j.bmc.2022.116804 | |||
| 11994156 | 82160 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 461 | 10 | 1 | 7 | 4.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| CHEMBL216688 | 82160 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 461 | 10 | 1 | 7 | 4.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| 162663560 | 182044 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 559 | 11 | 1 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 | 10.1016/j.bmc.2020.115859 | |||
| CHEMBL4779819 | 182044 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 559 | 11 | 1 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 | 10.1016/j.bmc.2020.115859 | |||
| 56678310 | 63271 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 1034 | 25 | 11 | 12 | 1.0 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)ccc2[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm030921v | |||
| CHEMBL1791259 | 63271 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 1034 | 25 | 11 | 12 | 1.0 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)ccc2[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm030921v | |||
| 10140382 | 141963 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 475 | 7 | 1 | 7 | 5.1 | CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 | 10.1021/jm0606185 | |||
| CHEMBL386671 | 141963 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 475 | 7 | 1 | 7 | 5.1 | CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 | 10.1021/jm0606185 | |||
| 9891811 | 119806 | None | 1 | Rat | Binding | pKi | = | 5.2 | 5.2 | -8128 | 2 | ChEMBL | 475 | 8 | 2 | 7 | 4.8 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL347703 | 119806 | None | 1 | Rat | Binding | pKi | = | 5.2 | 5.2 | -8128 | 2 | ChEMBL | 475 | 8 | 2 | 7 | 4.8 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL4524047 | 119806 | None | 1 | Rat | Binding | pKi | = | 5.2 | 5.2 | -8128 | 2 | ChEMBL | 475 | 8 | 2 | 7 | 4.8 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 10289461 | 67789 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 526 | 10 | 1 | 8 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3cccnc32)cc1 | 10.1021/jm049715t | |||
| CHEMBL190811 | 67789 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 526 | 10 | 1 | 8 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3cccnc32)cc1 | 10.1021/jm049715t | |||
| 162663467 | 182058 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 531 | 9 | 1 | 8 | 5.4 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 | 10.1016/j.bmc.2020.115859 | |||
| CHEMBL4779945 | 182058 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 531 | 9 | 1 | 8 | 5.4 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 | 10.1016/j.bmc.2020.115859 | |||
| 11316477 | 68116 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 434 | 9 | 1 | 6 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC#N)cc1 | 10.1021/jm049715t | |||
| CHEMBL191468 | 68116 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 434 | 9 | 1 | 6 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC#N)cc1 | 10.1021/jm049715t | |||
| 163848227 | 190220 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 518 | 10 | 1 | 8 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5173054 | 190220 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 518 | 10 | 1 | 8 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 145965035 | 164346 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | - | 1 | ChEMBL | 529 | 10 | 1 | 7 | 5.6 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 | 10.1016/j.bmcl.2017.11.042 | |||
| CHEMBL4211391 | 164346 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | - | 1 | ChEMBL | 529 | 10 | 1 | 7 | 5.6 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 | 10.1016/j.bmcl.2017.11.042 | |||
| 132404 | 119850 | None | 12 | Human | Binding | pKi | = | 6.1 | 6.1 | -36 | 2 | ChEMBL | 637 | 13 | 3 | 5 | 8.0 | CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 | 10.1021/jm9504722 | |||
| CHEMBL348126 | 119850 | None | 12 | Human | Binding | pKi | = | 6.1 | 6.1 | -36 | 2 | ChEMBL | 637 | 13 | 3 | 5 | 8.0 | CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 | 10.1021/jm9504722 | |||
| 10161763 | 80758 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 461 | 8 | 1 | 7 | 4.7 | CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)C)s1 | 10.1021/jm0606185 | |||
| CHEMBL215159 | 80758 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 461 | 8 | 1 | 7 | 4.7 | CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)C)s1 | 10.1021/jm0606185 | |||
| 10300357 | 141801 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 495 | 11 | 1 | 7 | 4.3 | CCCCS(=O)(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| CHEMBL385714 | 141801 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 495 | 11 | 1 | 7 | 4.3 | CCCCS(=O)(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| 4189 | 209380 | None | 58 | Human | Binding | pKi | = | 5.1 | 5.1 | -38 | 34 | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | |||
| CHEMBL1559 | 209380 | None | 58 | Human | Binding | pKi | = | 5.1 | 5.1 | -38 | 34 | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | |||
| CHEMBL91 | 209380 | None | 58 | Human | Binding | pKi | = | 5.1 | 5.1 | -38 | 34 | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | |||
| 10182998 | 141971 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 459 | 10 | 1 | 6 | 4.7 | CCCCS(=O)(=O)NC(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| CHEMBL386718 | 141971 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 459 | 10 | 1 | 6 | 4.7 | CCCCS(=O)(=O)NC(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| 132840 | 105545 | None | 22 | Rat | Binding | pKi | = | 4.1 | 4.1 | -3311 | 3 | ChEMBL | 426 | 6 | 2 | 8 | 3.5 | CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL312104 | 105545 | None | 22 | Rat | Binding | pKi | = | 4.1 | 4.1 | -3311 | 3 | ChEMBL | 426 | 6 | 2 | 8 | 3.5 | CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 11239632 | 100205 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 748 | 15 | 1 | 10 | 8.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4cccs4)cc3c2=O)cc1 | 10.1021/jm031031i | |||
| CHEMBL287829 | 100205 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 748 | 15 | 1 | 10 | 8.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4cccs4)cc3c2=O)cc1 | 10.1021/jm031031i | |||
| 118725969 | 117263 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1cccc(Cn2ccnc2)c1 | 10.1021/acs.jmedchem.5b00982 | |||
| CHEMBL3394209 | 117263 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1cccc(Cn2ccnc2)c1 | 10.1021/acs.jmedchem.5b00982 | |||
| 11251114 | 159279 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 714 | 14 | 2 | 9 | 7.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)c4ccccc4)cc3c2=O)cc1 | 10.1021/jm031031i | |||
| CHEMBL409843 | 159279 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 714 | 14 | 2 | 9 | 7.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)c4ccccc4)cc3c2=O)cc1 | 10.1021/jm031031i | |||
| 73213179 | 104761 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 511 | 10 | 3 | 6 | 3.0 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2013.12.040 | |||
| CHEMBL3105465 | 104761 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 511 | 10 | 3 | 6 | 3.0 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2013.12.040 | |||
| 10205901 | 82545 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 477 | 11 | 1 | 8 | 4.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CCOC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| CHEMBL217752 | 82545 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 477 | 11 | 1 | 8 | 4.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CCOC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | |||
| 168294859 | 192385 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 19 | 2 | ChEMBL | 561 | 13 | 1 | 6 | 7.3 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5205769 | 192385 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 19 | 2 | ChEMBL | 561 | 13 | 1 | 6 | 7.3 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 44400615 | 156708 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1007 | 22 | 11 | 13 | 0.4 | CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 | 10.1021/jm0491492 | |||
| CHEMBL406907 | 156708 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 1007 | 22 | 11 | 13 | 0.4 | CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 | 10.1021/jm0491492 | |||
| 162670036 | 182762 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 517 | 8 | 1 | 8 | 5.0 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 | 10.1016/j.bmc.2020.115859 | |||
| CHEMBL4788892 | 182762 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 517 | 8 | 1 | 8 | 5.0 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 | 10.1016/j.bmc.2020.115859 | |||
| 168275495 | 190580 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 66 | 2 | ChEMBL | 519 | 10 | 1 | 6 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5178838 | 190580 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 66 | 2 | ChEMBL | 519 | 10 | 1 | 6 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 11672486 | 98564 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 3 | 2 | ChEMBL | 994 | 25 | 12 | 12 | 0.3 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | |||
| CHEMBL276163 | 98564 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 3 | 2 | ChEMBL | 994 | 25 | 12 | 12 | 0.3 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | |||
| 166492458 | 191683 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 516 | 11 | 1 | 8 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5195051 | 191683 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 516 | 11 | 1 | 8 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 6918 | 1028 | None | 34 | Human | Binding | pKi | = | 8.0 | 8.0 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmcl.2013.12.040 | |||
| 9804984 | 1028 | None | 34 | Human | Binding | pKi | = | 8.0 | 8.0 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmcl.2013.12.040 | |||
| CHEMBL189568 | 1028 | None | 34 | Human | Binding | pKi | = | 8.0 | 8.0 | -3 | 3 | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmcl.2013.12.040 | |||
| 73213180 | 104762 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | - | 1 | ChEMBL | 499 | 11 | 3 | 7 | 2.1 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(OC)cc1 | 10.1016/j.bmcl.2013.12.040 | |||
| CHEMBL3105466 | 104762 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | - | 1 | ChEMBL | 499 | 11 | 3 | 7 | 2.1 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(OC)cc1 | 10.1016/j.bmcl.2013.12.040 | |||
| 73213252 | 104763 | None | 0 | Human | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 434 | 11 | 2 | 6 | 2.3 | CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)c1cccc(Cn2ccnc2)c1)[C@@H](C)CC | 10.1016/j.bmcl.2013.12.040 | |||
| CHEMBL3105467 | 104763 | None | 0 | Human | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 434 | 11 | 2 | 6 | 2.3 | CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)c1cccc(Cn2ccnc2)c1)[C@@H](C)CC | 10.1016/j.bmcl.2013.12.040 | |||
| 1610 | 2347 | None | 64 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 5 | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3941 | 2347 | None | 64 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 5 | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961 | 2347 | None | 64 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 5 | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961.0 | 2347 | None | 64 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 5 | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 590 | 2347 | None | 64 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 5 | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| CHEMBL191 | 2347 | None | 64 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 5 | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| DB00678 | 2347 | None | 64 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 5 | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 1037 | 1578 | None | 44 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 1 | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 3940 | 1578 | None | 44 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 1 | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 5281037 | 1578 | None | 44 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 1 | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 5281037.0 | 1578 | None | 44 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 1 | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 588 | 1578 | None | 44 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 1 | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| CHEMBL813 | 1578 | None | 44 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 1 | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| DB00876 | 1578 | None | 44 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 1 | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 2583 | 3776 | None | 69 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 1 | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 592 | 3776 | None | 69 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 1 | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 65999 | 3776 | None | 69 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 1 | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 65999.0 | 3776 | None | 69 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 1 | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| CHEMBL1017 | 3776 | None | 69 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 1 | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| DB00966 | 3776 | None | 69 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 1 | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 16133225 | 419 | None | 38 | Human | Binding | pKd | = | 8.0 | 8.0 | 1 | 4 | Drug Central | None | None | None | None | None | |||||
| 172198 | 419 | None | 38 | Human | Binding | pKd | = | 8.0 | 8.0 | 1 | 4 | Drug Central | None | None | None | None | None | |||||
| 172198.0 | 419 | None | 38 | Human | Binding | pKd | = | 8.0 | 8.0 | 1 | 4 | Drug Central | None | None | None | None | None | |||||
| 2504 | 419 | None | 38 | Human | Binding | pKd | = | 8.0 | 8.0 | 1 | 4 | Drug Central | None | None | None | None | None | |||||
| 45266664 | 419 | None | 38 | Human | Binding | pKd | = | 8.0 | 8.0 | 1 | 4 | Drug Central | None | None | None | None | None | |||||
| 5272 | 419 | None | 38 | Human | Binding | pKd | = | 8.0 | 8.0 | 1 | 4 | Drug Central | None | None | None | None | None | |||||
| CHEMBL408403 | 419 | None | 38 | Human | Binding | pKd | = | 8.0 | 8.0 | 1 | 4 | Drug Central | None | None | None | None | None | |||||
| DB11842 | 419 | None | 38 | Human | Binding | pKd | = | 8.0 | 8.0 | 1 | 4 | Drug Central | None | None | None | None | None | |||||
| 16133225 | 419 | None | 38 | Human | Binding | pKd | = | 10.2 | 10.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 2775266 | |||||
| 16133225 | 419 | None | 38 | Human | Binding | pKd | = | 10.2 | 10.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 7850406 | |||||
| 172198 | 419 | None | 38 | Human | Binding | pKd | = | 10.2 | 10.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 2775266 | |||||
| 172198 | 419 | None | 38 | Human | Binding | pKd | = | 10.2 | 10.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 7850406 | |||||
| 172198.0 | 419 | None | 38 | Human | Binding | pKd | = | 10.2 | 10.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 2775266 | |||||
| 172198.0 | 419 | None | 38 | Human | Binding | pKd | = | 10.2 | 10.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 7850406 | |||||
| 2504 | 419 | None | 38 | Human | Binding | pKd | = | 10.2 | 10.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 2775266 | |||||
| 2504 | 419 | None | 38 | Human | Binding | pKd | = | 10.2 | 10.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 7850406 | |||||
| 45266664 | 419 | None | 38 | Human | Binding | pKd | = | 10.2 | 10.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 2775266 | |||||
| 45266664 | 419 | None | 38 | Human | Binding | pKd | = | 10.2 | 10.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 7850406 | |||||
| 5272 | 419 | None | 38 | Human | Binding | pKd | = | 10.2 | 10.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 2775266 | |||||
| 5272 | 419 | None | 38 | Human | Binding | pKd | = | 10.2 | 10.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 7850406 | |||||
| CHEMBL408403 | 419 | None | 38 | Human | Binding | pKd | = | 10.2 | 10.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 2775266 | |||||
| CHEMBL408403 | 419 | None | 38 | Human | Binding | pKd | = | 10.2 | 10.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 7850406 | |||||
| DB11842 | 419 | None | 38 | Human | Binding | pKd | = | 10.2 | 10.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 2775266 | |||||
| DB11842 | 419 | None | 38 | Human | Binding | pKd | = | 10.2 | 10.2 | 1 | 4 | Guide to Pharmacology | None | None | None | None | 7850406 | |||||
| 44299731 | 420 | None | 0 | Human | Binding | pKd | = | 10.4 | 10.4 | - | 1 | Guide to Pharmacology | None | None | None | None | 2775266 | |||||
| 44299731 | 420 | None | 0 | Human | Binding | pKd | = | 10.4 | 10.4 | - | 1 | Guide to Pharmacology | None | None | None | None | 8242249 | |||||
| 585 | 420 | None | 0 | Human | Binding | pKd | = | 10.4 | 10.4 | - | 1 | Guide to Pharmacology | None | None | None | None | 2775266 | |||||
| 585 | 420 | None | 0 | Human | Binding | pKd | = | 10.4 | 10.4 | - | 1 | Guide to Pharmacology | None | None | None | None | 8242249 | |||||
| CHEMBL56448 | 420 | None | 0 | Human | Binding | pKd | = | 10.4 | 10.4 | - | 1 | Guide to Pharmacology | None | None | None | None | 2775266 | |||||
| CHEMBL56448 | 420 | None | 0 | Human | Binding | pKd | = | 10.4 | 10.4 | - | 1 | Guide to Pharmacology | None | None | None | None | 8242249 | |||||
| 123794 | 893 | None | 40 | Human | Binding | pKd | = | 10.6 | 10.6 | 67608 | 2 | Guide to Pharmacology | None | None | None | None | 1764088 | |||||
| 123794 | 893 | None | 40 | Human | Binding | pKd | = | 10.6 | 10.6 | 67608 | 2 | Guide to Pharmacology | None | None | None | None | 2775266 | |||||
| 3944 | 893 | None | 40 | Human | Binding | pKd | = | 10.6 | 10.6 | 67608 | 2 | Guide to Pharmacology | None | None | None | None | 1764088 | |||||
| 3944 | 893 | None | 40 | Human | Binding | pKd | = | 10.6 | 10.6 | 67608 | 2 | Guide to Pharmacology | None | None | None | None | 2775266 | |||||
| 594 | 893 | None | 40 | Human | Binding | pKd | = | 10.6 | 10.6 | 67608 | 2 | Guide to Pharmacology | None | None | None | None | 1764088 | |||||
| 594 | 893 | None | 40 | Human | Binding | pKd | = | 10.6 | 10.6 | 67608 | 2 | Guide to Pharmacology | None | None | None | None | 2775266 | |||||
| CHEMBL1885579 | 893 | None | 40 | Human | Binding | pKd | = | 10.6 | 10.6 | 67608 | 2 | Guide to Pharmacology | None | None | None | None | 1764088 | |||||
| CHEMBL1885579 | 893 | None | 40 | Human | Binding | pKd | = | 10.6 | 10.6 | 67608 | 2 | Guide to Pharmacology | None | None | None | None | 2775266 | |||||
| 5311345 | 3021 | None | 38 | Human | Binding | pKd | = | 9.0 | 9.0 | 10 | 2 | Guide to Pharmacology | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 1709220 | |||
| 5311345 | 3021 | None | 38 | Human | Binding | pKd | = | 9.0 | 9.0 | 10 | 2 | Guide to Pharmacology | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 2402226 | |||
| 597 | 3021 | None | 38 | Human | Binding | pKd | = | 9.0 | 9.0 | 10 | 2 | Guide to Pharmacology | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 1709220 | |||
| 597 | 3021 | None | 38 | Human | Binding | pKd | = | 9.0 | 9.0 | 10 | 2 | Guide to Pharmacology | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 2402226 | |||
| CHEMBL321820 | 3021 | None | 38 | Human | Binding | pKd | = | 9.0 | 9.0 | 10 | 2 | Guide to Pharmacology | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 1709220 | |||
| CHEMBL321820 | 3021 | None | 38 | Human | Binding | pKd | = | 9.0 | 9.0 | 10 | 2 | Guide to Pharmacology | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 2402226 | |||
| 595 | 2996 | None | 0 | Rat | Binding | pKd | = | 9.3 | 9.3 | - | 1 | Guide to Pharmacology | None | None | None | None | 2194459 | |||||
| 4189 | 209380 | None | 58 | Human | Binding | pKi | = | 8.3 | 8.3 | -38 | 34 | Drug Central | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | None | |||
| CHEMBL1559 | 209380 | None | 58 | Human | Binding | pKi | = | 8.3 | 8.3 | -38 | 34 | Drug Central | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | None | |||
| CHEMBL91 | 209380 | None | 58 | Human | Binding | pKi | = | 8.3 | 8.3 | -38 | 34 | Drug Central | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | None | |||
| 36736 | 3474 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -5 | 3 | Drug Central | None | None | None | None | None | |||||
| 598 | 3474 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -5 | 3 | Drug Central | None | None | None | None | None | |||||
| 6324663 | 3474 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -5 | 3 | Drug Central | None | None | None | None | None | |||||
| CHEMBL356431 | 3474 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -5 | 3 | Drug Central | None | None | None | None | None | |||||
| 6893 | 2867 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 18207609 | |||||
| 9987879 | 2867 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 18207609 | |||||
| 6894 | 418 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | -1 | 2 | Guide to Pharmacology | None | None | None | None | 21464395 | |||||
| 91691124 | 418 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | -1 | 2 | Guide to Pharmacology | None | None | None | None | 21464395 | |||||
| 6918 | 1028 | None | 34 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 3 | Guide to Pharmacology | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 15537354 | |||
| 9804984 | 1028 | None | 34 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 3 | Guide to Pharmacology | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 15537354 | |||
| CHEMBL189568 | 1028 | None | 34 | Human | Binding | pKi | = | 9.4 | 9.4 | -3 | 3 | Guide to Pharmacology | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 15537354 | |||
| 11931 | 1065 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 10 | 2 | Guide to Pharmacology | 621 | 10 | 1 | 8 | 6.7 | CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| 126456406 | 1065 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 10 | 2 | Guide to Pharmacology | 621 | 10 | 1 | 8 | 6.7 | CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| 11930 | 1019 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 537 | 2 | Guide to Pharmacology | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| 15780052 | 1019 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 537 | 2 | Guide to Pharmacology | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| CHEMBL289472 | 1019 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 537 | 2 | Guide to Pharmacology | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||