Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
CHEMBL438162 211994 0 None - 1 Mouse 9.2 pEC50 = 9.2 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(Br)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1242 12 None -2 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
9166 1242 12 None -2 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
CHEMBL230333 1242 12 None -2 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
CHEMBL437201 211952 0 None - 1 Mouse 9.2 pEC50 = 9.2 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(C)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL441576 212132 0 None - 1 Mouse 9.2 pEC50 = 9.2 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1242 12 None -2 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
9166 1242 12 None -2 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
CHEMBL230333 1242 12 None -2 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
1491 2748 10 None 2 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at mouse NPSR expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
CHEMBL1765705 2748 10 None 2 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at mouse NPSR expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
44123843 1242 12 None 2 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
9166 1242 12 None 2 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL230333 1242 12 None 2 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL430024 211848 0 None - 1 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL409981 211036 0 None - 1 Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL267034 208955 0 None - 1 Mouse 8.8 pEC50 = 8.8 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(I)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL398483 210767 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1C)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL398524 210768 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL390860 210688 0 None - 1 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL524693 213834 0 None - 1 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL453962 212228 0 None - 1 Mouse 7.0 pEC50 = 7.0 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL2372117 208433 0 None - 1 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@]1(NC(=O)[C@@H](N)CO)CCc2ccccc2C1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1242 12 None 2 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
9166 1242 12 None 2 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL230333 1242 12 None 2 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL499957 212324 0 None - 1 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL506383 212428 0 None - 1 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
5810 1324 0 None 3 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL526355 1324 0 None 3 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL401641 210770 0 None - 1 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL525447 213865 0 None - 1 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C 10.1016/j.bmc.2008.08.073
CHEMBL437838 211977 0 None - 1 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL409555 211011 0 None - 1 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(Cc1ccccc1)C(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL500802 212347 0 None - 1 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL396531 210741 0 None - 1 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL447434 212191 0 None - 1 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL500443 212331 0 None - 1 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](CC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O 10.1021/jm900604g
CHEMBL526551 213907 0 None - 1 Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL428331 211681 0 None - 1 Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL267266 208962 0 None - 1 Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL267479 208967 0 None - 1 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)C(C)(C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL439309 212079 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1242 12 None 2 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
9166 1242 12 None 2 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL230333 1242 12 None 2 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL525809 213876 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm8012294
CHEMBL400369 210769 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL437199 211951 0 None - 1 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL437389 211958 0 None - 1 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL510673 213800 0 None - 1 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL230108 207705 0 None - 1 Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL448242 212194 0 None - 1 Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCN/C(N)=N/[N+](=O)[O-])NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL524688 213833 0 None - 1 Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None C/N=C(/NC)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C 10.1016/j.bmc.2008.08.073
CHEMBL526323 213892 0 None - 1 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL437764 211975 0 None - 1 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL438866 212045 0 None - 1 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL505996 212419 0 None - 1 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL438115 211993 0 None - 1 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL229994 207704 0 None - 1 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL507664 212674 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CCC[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C 10.1021/jm900604g
CHEMBL263801 208834 0 None - 1 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL252537 208753 0 None - 1 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(C#N)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL411392 211125 0 None - 1 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL510338 213797 0 None - 1 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL524654 213827 0 None - 1 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL411571 211139 0 None - 1 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)C1(NC(=O)[C@@H](N)CO)Cc2ccccc2C1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL503441 212384 0 None - 1 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL413849 211334 0 None - 1 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1242 12 None 2 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm900604g
9166 1242 12 None 2 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm900604g
CHEMBL230333 1242 12 None 2 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm900604g
CHEMBL505174 212408 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C 10.1016/j.bmc.2008.08.073
CHEMBL451444 212209 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL425840 211582 0 None - 1 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)C(C)(C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
5811 1479 0 None - 1 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL505657 1479 0 None - 1 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL500458 212333 0 None - 1 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)c1ccccc1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O 10.1021/jm900604g
CHEMBL526492 213900 0 None - 1 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm8012294
CHEMBL525398 213860 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL509091 213500 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)[C@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O 10.1021/jm900604g
CHEMBL427638 211601 0 None - 1 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL268436 208998 0 None - 1 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
44580138 192752 0 None - 1 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL 2254 78 35 34 -13.2 CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCNC(=O)C(F)(F)F)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL525031 192752 0 None - 1 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL 2254 78 35 34 -13.2 CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCNC(=O)C(F)(F)F)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL507881 212805 0 None - 1 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL503354 212383 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
44123843 1242 12 None 2 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
9166 1242 12 None 2 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL230333 1242 12 None 2 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
44634573 2697 0 None 67 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
9168 2697 0 None 67 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1474387 2697 0 None 67 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1622930 2697 0 None 67 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
44156964 3184 0 None 6 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
5815 3184 0 None 6 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
CHEMBL1210313 3184 0 None 6 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
11177829 178281 1 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 427 4 1 3 4.0 O=C(NCc1ccccc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1016/j.bmcl.2010.10.067
CHEMBL469696 178281 1 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 427 4 1 3 4.0 O=C(NCc1ccccc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1016/j.bmcl.2010.10.067
50925457 19014 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 385 3 0 3 4.4 O=C(c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O)N1CCCCC1 10.1016/j.bmcl.2010.10.067
CHEMBL1290004 19014 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 385 3 0 3 4.4 O=C(c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O)N1CCCCC1 10.1016/j.bmcl.2010.10.067
44156964 3184 0 None 6 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
5815 3184 0 None 6 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
CHEMBL1210313 3184 0 None 6 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
44156964 3184 0 None 6 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
5815 3184 0 None 6 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
CHEMBL1210313 3184 0 None 6 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
50925457 19014 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 385 3 0 3 4.4 O=C(c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O)N1CCCCC1 10.1021/jm400904m
CHEMBL1290004 19014 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 385 3 0 3 4.4 O=C(c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O)N1CCCCC1 10.1021/jm400904m
44634570 43817 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 348 3 0 3 3.4 Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL1514777 43817 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 348 3 0 3 3.4 Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 10.1021/jm400904m
49863070 15014 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 481 9 0 5 4.7 CCC(CC)(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210411 15014 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 481 9 0 5 4.7 CCC(CC)(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
44634512 34814 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 7 0 2 4.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCc1ccccc1 10.1021/jm400904m
CHEMBL1433323 34814 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 7 0 2 4.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCc1ccccc1 10.1021/jm400904m
CHEMBL3086835 34814 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 7 0 2 4.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCc1ccccc1 10.1021/jm400904m
54578636 106020 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
CHEMBL3086836 106020 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
CHEMBL3140243 106020 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
46202039 63382 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 353 3 0 3 5.5 N#Cc1ccc(C2(CC3CCCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801330 63382 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 353 3 0 3 5.5 N#Cc1ccc(C2(CC3CCCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
54578634 106010 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
CHEMBL3086823 106010 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
CHEMBL3140209 106010 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
56676662 63385 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 502 6 0 4 5.8 CC(C1CCN(C(=O)CCC2(c3ccc(Cl)cc3)c3ccccc3-c3nccn32)CC1)N1CCCC1 10.1016/j.bmcl.2010.04.016
CHEMBL1801333 63385 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 502 6 0 4 5.8 CC(C1CCN(C(=O)CCC2(c3ccc(Cl)cc3)c3ccccc3-c3nccn32)CC1)N1CCCC1 10.1016/j.bmcl.2010.04.016
46907769 55317 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
CHEMBL1472563 55317 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
CHEMBL1621293 55317 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
44634561 47818 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
CHEMBL1550914 47818 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
CHEMBL3086833 47818 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
54578863 105986 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
CHEMBL3086820 105986 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
CHEMBL3140138 105986 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
56676661 63383 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 433 5 0 3 5.9 CCC1CCCCN1C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
CHEMBL1801331 63383 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 433 5 0 3 5.9 CCC1CCCCN1C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
46206934 63372 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 336 3 0 2 5.2 Cc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801320 63372 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 336 3 0 2 5.2 Cc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56659485 63379 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 364 3 0 3 5.1 Clc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801327 63379 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 364 3 0 3 5.1 Clc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56683317 63386 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 407 6 0 3 5.3 CCN(C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)C(C)C 10.1016/j.bmcl.2010.04.016
CHEMBL1801334 63386 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 407 6 0 3 5.3 CCN(C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)C(C)C 10.1016/j.bmcl.2010.04.016
49863016 15009 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 483 8 0 4 5.4 CCC(C)(CCN1CCC(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210311 15009 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 483 8 0 4 5.4 CCC(C)(CCN1CCC(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
76320765 103067 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 500 6 1 7 4.0 COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC 10.1021/jm400904m
CHEMBL3085788 103067 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 500 6 1 7 4.0 COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC 10.1021/jm400904m
49862985 15002 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 453 7 0 5 3.9 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCOCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
CHEMBL1210243 15002 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 453 7 0 5 3.9 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCOCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
46202040 63381 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 339 3 0 3 5.1 N#Cc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801329 63381 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 339 3 0 3 5.1 N#Cc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56669801 63411 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3cccnc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801362 63411 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3cccnc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56669836 63376 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cn1 10.1016/j.bmcl.2010.04.016
CHEMBL1801324 63376 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cn1 10.1016/j.bmcl.2010.04.016
56659483 63369 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 422 4 0 3 5.6 Brc1ccc(C2(CCC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801317 63369 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 422 4 0 3 5.6 Brc1ccc(C2(CCC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
49862947 14991 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 4.3 CC(CCN1CCCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210178 14991 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 4.3 CC(CCN1CCCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL267479 208967 0 None - 1 Mouse 5.8 pIC50 = 5.8 Functional
Antagonist activity at mouse NPSR expressed in HEK293 cells assessed as inhibition of 100 nM hNPS-induced calcium mobilizationAntagonist activity at mouse NPSR expressed in HEK293 cells assessed as inhibition of 100 nM hNPS-induced calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)C(C)(C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
46206599 63363 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801267 63363 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
54578638 106000 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
CHEMBL3086825 106000 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
CHEMBL3140174 106000 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
3278392 21137 2 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1314147 21137 2 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1593439 21137 2 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1598051 21137 2 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
3278392 21137 2 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1314147 21137 2 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1593439 21137 2 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1598051 21137 2 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
56679981 63374 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1cccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)c1 10.1016/j.bmcl.2010.04.016
CHEMBL1801322 63374 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1cccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)c1 10.1016/j.bmcl.2010.04.016
46208464 14990 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 492 6 0 5 4.4 CN1CCN(C2(CN(Cc3cc4ccccc4n(C)c3=O)C(=O)C3CCCCC3)CCCCC2)CC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210177 14990 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 492 6 0 5 4.4 CN1CCN(C2(CN(Cc3cc4ccccc4n(C)c3=O)C(=O)C3CCCCC3)CCCCC2)CC1 10.1016/j.bmcl.2010.04.143
44634570 43817 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 348 3 0 3 3.4 Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL1514777 43817 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 348 3 0 3 3.4 Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 10.1021/jm400904m
50925456 18971 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 385 4 1 3 4.6 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccc(-c2ccccc2)n1 10.1016/j.bmcl.2010.10.067
CHEMBL1289677 18971 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 385 4 1 3 4.6 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccc(-c2ccccc2)n1 10.1016/j.bmcl.2010.10.067
54578634 106010 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
CHEMBL3086823 106010 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
CHEMBL3140209 106010 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
44634508 54868 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL1315807 54868 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL1617408 54868 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
72735980 106018 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
CHEMBL3086834 106018 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
CHEMBL3140236 106018 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
46202042 63377 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)nc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801325 63377 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)nc1 10.1016/j.bmcl.2010.04.016
49863017 15010 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 501 8 0 4 5.7 CCC(C)(CCN1CCC(F)(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210312 15010 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 501 8 0 4 5.7 CCC(C)(CCN1CCC(F)(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
54578860 106034 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
CHEMBL3086838 106034 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
CHEMBL3140268 106034 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
44156964 3184 0 None 6 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
5815 3184 0 None 6 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
CHEMBL1210313 3184 0 None 6 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
54578862 105976 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
CHEMBL3086826 105976 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
CHEMBL3140102 105976 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
56666419 63390 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 538 6 0 4 6.1 CC(C1CCN(C(=O)CCC2(c3ccc(Cl)cc3)c3ccccc3-c3nccn32)CC1)N1CCC(F)(F)C1 10.1016/j.bmcl.2010.04.016
CHEMBL1801338 63390 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 538 6 0 4 6.1 CC(C1CCN(C(=O)CCC2(c3ccc(Cl)cc3)c3ccccc3-c3nccn32)CC1)N1CCC(F)(F)C1 10.1016/j.bmcl.2010.04.016
44634578 55503 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL1476356 55503 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL1622833 55503 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL3086829 55503 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
52944769 18987 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 384 4 1 2 5.2 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccc(-c2ccccc2)c1 10.1016/j.bmcl.2010.10.067
CHEMBL1289780 18987 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 384 4 1 2 5.2 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccc(-c2ccccc2)c1 10.1016/j.bmcl.2010.10.067
46205608 63366 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 406 3 0 2 6.4 Brc1ccc(C2(CC3CCCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801270 63366 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 406 3 0 2 6.4 Brc1ccc(C2(CC3CCCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
11177829 178281 1 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 427 4 1 3 4.0 O=C(NCc1ccccc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1021/jm400904m
CHEMBL469696 178281 1 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 427 4 1 3 4.0 O=C(NCc1ccccc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1021/jm400904m
8088007 103123 8 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 396 4 0 4 3.8 O=C1c2ccccc2C(=O)C1(c1ccccc1)N1CCN(Cc2ccccc2)CC1 10.1021/jm400904m
CHEMBL3086828 103123 8 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 396 4 0 4 3.8 O=C1c2ccccc2C(=O)C1(c1ccccc1)N1CCN(Cc2ccccc2)CC1 10.1021/jm400904m
44634521 30388 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 332 3 0 3 3.3 Cc1nc2ccccn2c1P(=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL1394028 30388 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 332 3 0 3 3.3 Cc1nc2ccccn2c1P(=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
11374217 3527 36 None -3 3 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3527 36 None -3 3 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3527 36 None -3 3 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
3989078 52062 2 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 361 3 0 2 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)c2ccccc2n1C 10.1021/jm400904m
CHEMBL1589741 52062 2 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 361 3 0 2 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)c2ccccc2n1C 10.1021/jm400904m
54578636 106020 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
CHEMBL3086836 106020 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
CHEMBL3140243 106020 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
54578635 105992 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
CHEMBL3086821 105992 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
CHEMBL3140149 105992 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
54578637 106022 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
CHEMBL3086837 106022 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
CHEMBL3140246 106022 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
49862984 15001 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 451 7 0 4 5.1 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
CHEMBL1210242 15001 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 451 7 0 4 5.1 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
52942771 18953 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 374 4 1 3 4.8 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1ccc(-c2ccccc2)o1 10.1016/j.bmcl.2010.10.067
CHEMBL1289571 18953 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 374 4 1 3 4.8 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1ccc(-c2ccccc2)o1 10.1016/j.bmcl.2010.10.067
56666418 63375 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 347 3 0 3 4.8 N#Cc1cccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)c1 10.1016/j.bmcl.2010.04.016
CHEMBL1801323 63375 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 347 3 0 3 4.8 N#Cc1cccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)c1 10.1016/j.bmcl.2010.04.016
44634561 47818 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
CHEMBL1550914 47818 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
CHEMBL3086833 47818 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
46205607 63367 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 392 3 0 2 6.0 Brc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801271 63367 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 392 3 0 2 6.0 Brc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
49862983 15000 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 437 7 0 4 4.7 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
CHEMBL1210241 15000 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 437 7 0 4 4.7 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
72736545 106021 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
CHEMBL3086822 106021 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
CHEMBL3140244 106021 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
56676659 63370 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 340 3 0 2 5.0 Fc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801318 63370 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 340 3 0 2 5.0 Fc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
44634514 26085 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 302 3 0 2 3.1 c1ccc(P(c2ccccc2)c2cnc3ccccn23)cc1 10.1021/jm400904m
CHEMBL1358647 26085 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 302 3 0 2 3.1 c1ccc(P(c2ccccc2)c2cnc3ccccn23)cc1 10.1021/jm400904m
46206933 63365 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3cccnc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801269 63365 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3cccnc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56659484 63371 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 356 3 0 2 5.6 Clc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801319 63371 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 356 3 0 2 5.6 Clc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
46206931 63364 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 425 3 0 3 5.5 N#Cc1ccccc1CC1(c2ccc(Br)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
CHEMBL1801268 63364 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 425 3 0 3 5.5 N#Cc1ccccc1CC1(c2ccc(Br)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
46206599 63363 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801267 63363 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
46189900 63373 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 347 3 0 3 4.8 N#Cc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801321 63373 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 347 3 0 3 4.8 N#Cc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
44634578 55503 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL1476356 55503 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL1622833 55503 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL3086829 55503 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
49863071 15015 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 493 7 0 5 4.9 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C2(CCN3CCOCC3)CCCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
CHEMBL1210412 15015 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 493 7 0 5 4.9 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C2(CCN3CCOCC3)CCCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
54578861 106035 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
CHEMBL3086824 106035 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
CHEMBL3140269 106035 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
54578861 106035 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
CHEMBL3086824 106035 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
CHEMBL3140269 106035 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
44634544 30378 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 334 3 0 3 3.1 S=P(c1ccccc1)(c1ccccc1)c1cnc2ccccn12 10.1021/jm400904m
CHEMBL1393909 30378 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 334 3 0 3 3.1 S=P(c1ccccc1)(c1ccccc1)c1cnc2ccccn12 10.1021/jm400904m
11374217 3527 36 None -3 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3527 36 None -3 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3527 36 None -3 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
11374217 3527 36 None -3 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3527 36 None -3 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3527 36 None -3 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
46203026 3058 1 None 128 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1016/j.bmcl.2010.04.016
5814 3058 1 None 128 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1016/j.bmcl.2010.04.016
CHEMBL1801361 3058 1 None 128 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1016/j.bmcl.2010.04.016
46203026 3058 1 None 128 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1021/jm400904m
5814 3058 1 None 128 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1021/jm400904m
CHEMBL1801361 3058 1 None 128 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1021/jm400904m
44634573 2697 0 None 67 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
9168 2697 0 None 67 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1474387 2697 0 None 67 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1622930 2697 0 None 67 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
72736373 105977 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
CHEMBL3086827 105977 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
CHEMBL3140103 105977 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
46206598 63409 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 394 4 0 4 5.1 COc1cccc2c1C(CC1CCOCC1)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
CHEMBL1801359 63409 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 394 4 0 4 5.1 COc1cccc2c1C(CC1CCOCC1)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
76320765 103067 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 500 6 1 7 4.0 COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC 10.1021/jm400904m
CHEMBL3085788 103067 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 500 6 1 7 4.0 COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC 10.1021/jm400904m
11374217 3527 36 None -3 3 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3527 36 None -3 3 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3527 36 None -3 3 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
54578638 106000 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
CHEMBL3086825 106000 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
CHEMBL3140174 106000 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
56662909 63410 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 449 5 0 4 5.5 COc1ccc2c(c1)C(CCC(=O)N1[C@@H](C)CC[C@H]1C)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
CHEMBL1801360 63410 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 449 5 0 4 5.5 COc1ccc2c(c1)C(CCC(=O)N1[C@@H](C)CC[C@H]1C)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
3278392 21137 2 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1314147 21137 2 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1593439 21137 2 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1598051 21137 2 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
3278392 21137 2 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1314147 21137 2 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1593439 21137 2 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1598051 21137 2 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL267479 208967 0 None - 1 Mouse 6.3 pIC50 = 6.3 Functional
Antagonist activity at mouse NPSR expressed in HEK293 cells assessed as inhibition of 10 nM hNPS-induced calcium mobilizationAntagonist activity at mouse NPSR expressed in HEK293 cells assessed as inhibition of 10 nM hNPS-induced calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)C(C)(C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
44156964 3184 0 None 6 2 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
5815 3184 0 None 6 2 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
CHEMBL1210313 3184 0 None 6 2 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
44634544 30378 0 None - 1 Human 4.2 pIC50 = 4.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 334 3 0 3 3.1 S=P(c1ccccc1)(c1ccccc1)c1cnc2ccccn12 10.1021/jm400904m
CHEMBL1393909 30378 0 None - 1 Human 4.2 pIC50 = 4.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 334 3 0 3 3.1 S=P(c1ccccc1)(c1ccccc1)c1cnc2ccccn12 10.1021/jm400904m
56676660 63378 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 355 3 0 4 4.3 N#Cc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801326 63378 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 355 3 0 4 4.3 N#Cc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
54578863 105986 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
CHEMBL3086820 105986 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
CHEMBL3140138 105986 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
56679926 63164 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 348 3 0 3 4.6 Fc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1800088 63164 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 348 3 0 3 4.6 Fc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
54578862 105976 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
CHEMBL3086826 105976 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
CHEMBL3140102 105976 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
49862986 15003 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 465 8 0 4 5.5 CCC(C)(CCN1CCCCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210244 15003 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 465 8 0 4 5.5 CCC(C)(CCN1CCCCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
54578635 105992 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
CHEMBL3086821 105992 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
CHEMBL3140149 105992 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
46907769 55317 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
CHEMBL1472563 55317 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
CHEMBL1621293 55317 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
49862948 14992 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 439 7 0 5 3.6 CC(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210179 14992 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 439 7 0 5 3.6 CC(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
44634508 54868 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL1315807 54868 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL1617408 54868 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
44634539 39366 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 347 3 0 2 3.9 Cn1cc(P(=S)(c2ccccc2)c2ccccc2)c2ccccc21 10.1021/jm400904m
CHEMBL1474223 39366 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 347 3 0 2 3.9 Cn1cc(P(=S)(c2ccccc2)c2ccccc2)c2ccccc21 10.1021/jm400904m
44156964 3184 0 None 6 2 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
5815 3184 0 None 6 2 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
CHEMBL1210313 3184 0 None 6 2 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
35277770 18972 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 390 4 1 3 5.3 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1ccc(-c2ccccc2)s1 10.1016/j.bmcl.2010.10.067
CHEMBL1289678 18972 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 390 4 1 3 5.3 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1ccc(-c2ccccc2)s1 10.1016/j.bmcl.2010.10.067
72735980 106018 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
CHEMBL3086834 106018 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
CHEMBL3140236 106018 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
46202376 63408 0 None 85 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 394 4 0 4 5.1 COc1ccc2c(c1)C(CC1CCOCC1)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
CHEMBL1801358 63408 0 None 85 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 394 4 0 4 5.1 COc1ccc2c(c1)C(CC1CCOCC1)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
72736373 105977 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
CHEMBL3086827 105977 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
CHEMBL3140103 105977 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
46202041 63380 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 393 3 0 3 5.4 Brc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cn1 10.1016/j.bmcl.2010.04.016
CHEMBL1801328 63380 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 393 3 0 3 5.4 Brc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cn1 10.1016/j.bmcl.2010.04.016
72736545 106021 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
CHEMBL3086822 106021 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
CHEMBL3140244 106021 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
54578860 106034 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
CHEMBL3086838 106034 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
CHEMBL3140268 106034 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
56662946 63389 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 393 6 0 3 5.0 CCN(CC)C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
CHEMBL1801337 63389 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 393 6 0 3 5.0 CCN(CC)C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
56676652 63368 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 408 3 0 3 5.2 Brc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801272 63368 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 408 3 0 3 5.2 Brc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56662945 63388 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 419 4 0 3 5.5 C[C@H]1CC[C@@H](C)N1C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
CHEMBL1801336 63388 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 419 4 0 3 5.5 C[C@H]1CC[C@@H](C)N1C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
54578637 106022 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
CHEMBL3086837 106022 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
CHEMBL3140246 106022 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
46907767 55696 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 481 8 0 2 5.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCc1ccccc1 10.1021/jm400904m
CHEMBL1553073 55696 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 481 8 0 2 5.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCc1ccccc1 10.1021/jm400904m
CHEMBL1624484 55696 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 481 8 0 2 5.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCc1ccccc1 10.1021/jm400904m
56683318 63387 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 431 4 0 3 5.6 O=C(CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)N1C2CCCC1CC2 10.1016/j.bmcl.2010.04.016
CHEMBL1801335 63387 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 431 4 0 3 5.6 O=C(CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)N1C2CCCC1CC2 10.1016/j.bmcl.2010.04.016
56659486 63384 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 421 6 0 3 5.7 CC(C)N(C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)C(C)C 10.1016/j.bmcl.2010.04.016
CHEMBL1801332 63384 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 421 6 0 3 5.7 CC(C)N(C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)C(C)C 10.1016/j.bmcl.2010.04.016
11374217 3527 36 None 3 3 Mouse 7.8 pKd = 7.8 Functional
Antagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assayAntagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/acs.jmedchem.0c02223
5813 3527 36 None 3 3 Mouse 7.8 pKd = 7.8 Functional
Antagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assayAntagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/acs.jmedchem.0c02223
CHEMBL469695 3527 36 None 3 3 Mouse 7.8 pKd = 7.8 Functional
Antagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assayAntagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/acs.jmedchem.0c02223
CHEMBL5077621 212727 0 None - 0 Mouse 7.6 pKd = 7.6 Functional
Antagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assayAntagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assay
ChEMBL None None None O=C(NCc1ccc(F)cc1)N1C[C@H](c2ccccc2)N2C(=O)OC(c3ccccc3)(c3ccccc3)[C@H]2C1 10.1021/acs.jmedchem.0c02223
CHEMBL5091859 213546 0 None - 0 Mouse 7.1 pKd = 7.1 Functional
Antagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assayAntagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assay
ChEMBL None None None N=C(NCc1ccc(F)cc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1021/acs.jmedchem.0c02223
6893971 71766 7 None - 1 Human 9.0 pPotency = 9 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 270 4 1 5 2.3 COc1ccc(/C=N/NC(=S)SC)cc1OC nan
CHEMBL1978331 71766 7 None - 1 Human 9.0 pPotency = 9 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 270 4 1 5 2.3 COc1ccc(/C=N/NC(=S)SC)cc1OC nan
6893971 71766 7 None - 1 Human 9.0 pPotency = 9 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 270 4 1 5 2.3 COc1ccc(/C=N/NC(=S)SC)cc1OC nan
CHEMBL1978331 71766 7 None - 1 Human 9.0 pPotency = 9 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 270 4 1 5 2.3 COc1ccc(/C=N/NC(=S)SC)cc1OC nan
73453 29388 22 None -117 16 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
CHEMBL1385840 29388 22 None -117 16 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
73453 29388 22 None -117 16 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
CHEMBL1385840 29388 22 None -117 16 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
3739574 19331 15 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 4 0 4 4.7 Cc1cc(C)n(Cc2ccc(Cl)cc2Cl)c(=O)c1S(=O)(=O)c1ccccc1 nan
CHEMBL1299616 19331 15 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 4 0 4 4.7 Cc1cc(C)n(Cc2ccc(Cl)cc2Cl)c(=O)c1S(=O)(=O)c1ccccc1 nan
3242822 21758 5 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 402 5 1 5 3.0 CCOC(=O)c1ccc(NS(=O)(=O)c2ccc3c(c2)CCCN3C(C)=O)cc1 nan
CHEMBL1320806 21758 5 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 402 5 1 5 3.0 CCOC(=O)c1ccc(NS(=O)(=O)c2ccc3c(c2)CCCN3C(C)=O)cc1 nan
795881 24954 39 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 226 5 1 2 2.9 CCc1ccc(CNCc2cccnc2)cc1 nan
CHEMBL1347786 24954 39 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 226 5 1 2 2.9 CCc1ccc(CNCc2cccnc2)cc1 nan
645241 25139 1 None 1584 2 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 3 5 4.8 COc1cc(NC(=O)c2ccco2)c(OC)cc1NC(=O)Nc1ccc(Cl)cc1 nan
CHEMBL1349430 25139 1 None 1584 2 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 3 5 4.8 COc1cc(NC(=O)c2ccco2)c(OC)cc1NC(=O)Nc1ccc(Cl)cc1 nan
654157 27130 2 None 1995 2 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 1 0 3 3.8 Cn1c(C(=O)N2CCCc3ccccc32)cc2sccc21 nan
CHEMBL1367658 27130 2 None 1995 2 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 1 0 3 3.8 Cn1c(C(=O)N2CCCc3ccccc32)cc2sccc21 nan
44663783 38879 15 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 4 3 4 4.9 CCN(CC)c1ccc(C2Nc3cccc4cccc(c34)N2)c(O)c1 nan
660794 38879 15 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 4 3 4 4.9 CCN(CC)c1ccc(C2Nc3cccc4cccc(c34)N2)c(O)c1 nan
CHEMBL1469355 38879 15 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 4 3 4 4.9 CCN(CC)c1ccc(C2Nc3cccc4cccc(c34)N2)c(O)c1 nan
645086 39947 18 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 5 2 3 2.0 O=C(O)CCNS(=O)(=O)c1ccc2c(c1)Cc1ccccc1-2 nan
CHEMBL1480317 39947 18 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 5 2 3 2.0 O=C(O)CCNS(=O)(=O)c1ccc2c(c1)Cc1ccccc1-2 nan
11958558 44597 0 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 7 3 4 5.0 O=C(Cc1ccc(Nc2nc3cc(Br)ccc3[nH]2)cc1)NCCc1cccs1 nan
CHEMBL1522550 44597 0 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 7 3 4 5.0 O=C(Cc1ccc(Nc2nc3cc(Br)ccc3[nH]2)cc1)NCCc1cccs1 nan
741701 47468 10 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 5 1 6 3.4 CCOC(=O)c1cnn(-c2ccccc2)c1NC(=O)c1cccs1 nan
CHEMBL1547978 47468 10 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 5 1 6 3.4 CCOC(=O)c1cnn(-c2ccccc2)c1NC(=O)c1cccs1 nan
664554 47792 7 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 391 2 2 8 1.9 COc1ccc(C2NC3=C(CCC3)C3(C#N)C4(N=C(N)C23C#N)OCCO4)cc1 nan
CHEMBL1550682 47792 7 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 391 2 2 8 1.9 COc1ccc(C2NC3=C(CCC3)C3(C#N)C4(N=C(N)C23C#N)OCCO4)cc1 nan
2093009 51983 6 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 5 1 5 3.4 Cc1ccc(NC(=O)c2cc(S(=O)(=O)N3CCCCC3)ccc2N2CCOCC2)cc1F nan
CHEMBL1589089 51983 6 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 5 1 5 3.4 Cc1ccc(NC(=O)c2cc(S(=O)(=O)N3CCCCC3)ccc2N2CCOCC2)cc1F nan
653853 54319 8 None 501 2 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 287 5 1 5 1.7 COc1ccc(CNC(=O)c2cnc(C)cn2)c(OC)c1 nan
CHEMBL1610905 54319 8 None 501 2 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 287 5 1 5 1.7 COc1ccc(CNC(=O)c2cnc(C)cn2)c(OC)c1 nan
135513617 108387 4 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 159 3 2 5 0.2 CC(=N\O)/C(CN(C)C)=N/O nan
CHEMBL3210731 108387 4 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 159 3 2 5 0.2 CC(=N\O)/C(CN(C)C)=N/O nan
2930697 20328 8 None 316 2 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 1 0 2 3.5 Cc1cc(N2C(=O)C3CC=CCC3C2=O)cc(C)c1Br nan
CHEMBL1307695 20328 8 None 316 2 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 1 0 2 3.5 Cc1cc(N2C(=O)C3CC=CCC3C2=O)cc(C)c1Br nan
135521609 22472 4 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 2 1 4 3.6 N#C/C(=C\c1c[nH]c2ccccc12)c1nnc2n1CCCCC2 nan
CHEMBL1327226 22472 4 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 2 1 4 3.6 N#C/C(=C\c1c[nH]c2ccccc12)c1nnc2n1CCCCC2 nan
2942941 23762 10 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 417 6 1 6 3.6 O=C(c1ccccc1)N1CCN(c2ccc([N+](=O)[O-])c(NCc3cccnc3)c2)CC1 nan
CHEMBL1337599 23762 10 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 417 6 1 6 3.6 O=C(c1ccccc1)N1CCN(c2ccc([N+](=O)[O-])c(NCc3cccnc3)c2)CC1 nan
718615 23890 17 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 295 4 1 4 3.9 CCCC(=O)Nc1cc(-c2nc3ncccc3o2)ccc1C nan
CHEMBL1338647 23890 17 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 295 4 1 4 3.9 CCCC(=O)Nc1cc(-c2nc3ncccc3o2)ccc1C nan
3159744 24040 14 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 5 1 6 3.1 CCC1CCCCN1CC(O)Cn1c2ccccc2n2c(=O)cc(C)c(C#N)c12 nan
CHEMBL1340098 24040 14 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 5 1 6 3.1 CCC1CCCCN1CC(O)Cn1c2ccccc2n2c(=O)cc(C)c(C#N)c12 nan
2767910 29568 15 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 3 0 3 4.9 Cc1ccc(Oc2ncc(-c3ccc(Cl)cc3)cn2)cc1 nan
CHEMBL1387210 29568 15 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 3 0 3 4.9 Cc1ccc(Oc2ncc(-c3ccc(Cl)cc3)cn2)cc1 nan
3239019 31214 11 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 478 8 1 8 2.8 CCOC(=O)N1CCN(C(=O)CSCC(=O)Nc2nc(-c3ccc(OC)cc3)cs2)CC1 nan
CHEMBL1402832 31214 11 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 478 8 1 8 2.8 CCOC(=O)N1CCN(C(=O)CSCC(=O)Nc2nc(-c3ccc(OC)cc3)cs2)CC1 nan
649843 31355 11 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 236 1 1 3 0.9 CN1CCN(CC#CC2(O)CCCCC2)CC1 nan
CHEMBL1404160 31355 11 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 236 1 1 3 0.9 CN1CCN(CC#CC2(O)CCCCC2)CC1 nan
2011082 34535 8 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 4 2 2 6.1 Cc1cccc(NC(=O)Nc2cccc(Oc3c(F)c(F)c(F)c(F)c3F)c2)c1 nan
CHEMBL1430872 34535 8 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 4 2 2 6.1 Cc1cccc(NC(=O)Nc2cccc(Oc3c(F)c(F)c(F)c(F)c3F)c2)c1 nan
661165 38592 8 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 406 5 0 6 3.5 CCN(CC)C(=O)C1CCN(c2ncnc3c2cnn3-c2ccc(C)cc2C)CC1 nan
CHEMBL1466877 38592 8 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 406 5 0 6 3.5 CCN(CC)C(=O)C1CCN(c2ncnc3c2cnn3-c2ccc(C)cc2C)CC1 nan
5308493 43016 2 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 495 6 1 6 5.2 Cc1oc(-c2cccc(Cl)c2)nc1CN1CCCC(C(=O)NC(C)c2ccc3c(c2)OCCO3)C1 nan
CHEMBL1506451 43016 2 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 495 6 1 6 5.2 Cc1oc(-c2cccc(Cl)c2)nc1CN1CCCC(C(=O)NC(C)c2ccc3c(c2)OCCO3)C1 nan
660432 44049 4 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 335 4 0 5 3.9 COc1cc2nc(-c3ccccc3)nc(N3CCCC3)c2cc1OC nan
CHEMBL1517669 44049 4 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 335 4 0 5 3.9 COc1cc2nc(-c3ccccc3)nc(N3CCCC3)c2cc1OC nan
654643 49811 6 None 199 2 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 5 2 4 5.4 Cc1ccc(C)c2nc(O)c(CN(Cc3ccco3)C(=O)Nc3ccccc3)cc12 nan
CHEMBL1570008 49811 6 None 199 2 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 5 2 4 5.4 Cc1ccc(C)c2nc(O)c(CN(Cc3ccco3)C(=O)Nc3ccccc3)cc12 nan
3477545 50675 9 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 390 10 2 5 1.7 CCN(CC)CCCN/C=C1\C(=O)NC(=O)N(CCc2ccc(F)cc2)C1=O nan
CHEMBL1578105 50675 9 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 390 10 2 5 1.7 CCN(CC)CCCN/C=C1\C(=O)NC(=O)N(CCc2ccc(F)cc2)C1=O nan
1131991 50954 7 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 374 6 1 8 3.0 CCc1nnc(NC(=O)CSc2nnc(C)n2-c2ccc(C)cc2)s1 nan
CHEMBL1580484 50954 7 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 374 6 1 8 3.0 CCc1nnc(NC(=O)CSc2nnc(C)n2-c2ccc(C)cc2)s1 nan
2767561 51763 13 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 428 6 2 8 -0.1 COc1ccc(CCN2C(=O)C3C4CC(C5C(C(=O)NN)=NOC45)C3C2=O)cc1OC nan
CHEMBL1587194 51763 13 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 428 6 2 8 -0.1 COc1ccc(CCN2C(=O)C3C4CC(C5C(C(=O)NN)=NOC45)C3C2=O)cc1OC nan
2973251 53296 8 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 354 5 3 4 2.8 O=C(O)c1cccc(NC(=O)c2cccc(NC(=O)C3CCCO3)c2)c1 nan
CHEMBL1602433 53296 8 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 354 5 3 4 2.8 O=C(O)c1cccc(NC(=O)c2cccc(NC(=O)C3CCCO3)c2)c1 nan
3939641 54194 6 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 8 2 7 3.0 CCCCN1C(=O)Cc2c1nc(N)c1c(N)nc(N(CCC)CCC)c(C#N)c21 nan
CHEMBL1609794 54194 6 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 8 2 7 3.0 CCCCN1C(=O)Cc2c1nc(N)c1c(N)nc(N(CCC)CCC)c(C#N)c21 nan
12005042 54566 2 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 348 7 1 3 4.7 CCc1ccccc1NC(=O)CC(c1ccc(OC)cc1)n1cccc1 nan
CHEMBL1613111 54566 2 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 348 7 1 3 4.7 CCc1ccccc1NC(=O)CC(c1ccc(OC)cc1)n1cccc1 nan
1983185 54691 2 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 207 0 2 6 -1.3 NNC1=N[C@H]2CS(=O)(=O)C[C@H]2S1 nan
CHEMBL1335567 54691 2 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 207 0 2 6 -1.3 NNC1=N[C@H]2CS(=O)(=O)C[C@H]2S1 nan
CHEMBL1616085 54691 2 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 207 0 2 6 -1.3 NNC1=N[C@H]2CS(=O)(=O)C[C@H]2S1 nan
4111848 55054 8 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 5 0 6 4.8 c1coc(CN(Cc2ccco2)c2ncnc3c2oc2ccccc23)c1 nan
CHEMBL1387307 55054 8 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 5 0 6 4.8 c1coc(CN(Cc2ccco2)c2ncnc3c2oc2ccccc23)c1 nan
CHEMBL1618998 55054 8 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 5 0 6 4.8 c1coc(CN(Cc2ccco2)c2ncnc3c2oc2ccccc23)c1 nan
5994795 108635 4 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 462 7 1 7 4.1 COc1cc(/C(C)=N/NC(=O)c2cnn(-c3ccccc3)c2C(F)(F)F)cc(OC)c1OC nan
CHEMBL3213983 108635 4 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 462 7 1 7 4.1 COc1cc(/C(C)=N/NC(=O)c2cnn(-c3ccccc3)c2C(F)(F)F)cc(OC)c1OC nan
32798 10066 64 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 466 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C nan
CHEMBL1159650 10066 64 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 466 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C nan
32798 10066 64 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 466 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C nan
CHEMBL1159650 10066 64 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 466 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C nan
330973 49406 3 None 5 4 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
CHEMBL1566610 49406 3 None 5 4 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
4464266 23286 11 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 325 1 1 4 4.5 Nc1ncnc2c1C(c1ccccc1)c1c(ccc3ccccc13)O2 nan
CHEMBL1333735 23286 11 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 325 1 1 4 4.5 Nc1ncnc2c1C(c1ccccc1)c1c(ccc3ccccc13)O2 nan
3245442 39571 14 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 467 7 1 7 5.0 CCOC(=O)C1CCN(C(c2cccnc2)c2c(NC(=O)c3ccco3)sc(C)c2C)CC1 nan
CHEMBL1477013 39571 14 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 467 7 1 7 5.0 CCOC(=O)C1CCN(C(c2cccnc2)c2c(NC(=O)c3ccco3)sc(C)c2C)CC1 nan
330973 49406 3 None 5 4 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
CHEMBL1566610 49406 3 None 5 4 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
221 3422 63 None 15 3 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 286 2 2 4 3.6 O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C nan
3277600 3422 63 None 15 3 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 286 2 2 4 3.6 O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C nan
CHEMBL323356 3422 63 None 15 3 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 286 2 2 4 3.6 O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C nan
2131 3430 63 None -95 4 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 nan
6604009 3430 63 None -95 4 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 nan
CHEMBL10284 3430 63 None -95 4 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 nan
11957729 9301 0 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 2 1 2 3.1 C[N+]1(C)C2CCC1CC(OC(=O)c1c[nH]c3ccccc13)C2 nan
CHEMBL111583 9301 0 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 2 1 2 3.1 C[N+]1(C)C2CCC1CC(OC(=O)c1c[nH]c3ccccc13)C2 nan
CHEMBL1456417 9301 0 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 2 1 2 3.1 C[N+]1(C)C2CCC1CC(OC(=O)c1c[nH]c3ccccc13)C2 nan
990305 19737 12 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 532 5 3 6 4.6 N#Cc1c(-c2ccccc2)c(-c2ccccc2)nn(CC(=O)NNC(=O)Nc2ccc(Cl)c(Cl)c2)c1=O nan
CHEMBL1302894 19737 12 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 532 5 3 6 4.6 N#Cc1c(-c2ccccc2)c(-c2ccccc2)nn(CC(=O)NNC(=O)Nc2ccc(Cl)c(Cl)c2)c1=O nan
663874 22099 8 None 6 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 4 1 5 2.3 CC(=O)c1c(C(C)=O)c(C)n(NC(=O)c2cccnc2)c1C nan
CHEMBL1323851 22099 8 None 6 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 4 1 5 2.3 CC(=O)c1c(C(C)=O)c(C)n(NC(=O)c2cccnc2)c1C nan
976409 22336 16 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 318 3 1 4 3.7 Cc1ccc(C)c(S(=O)(=O)Nc2ccc3scnc3c2)c1 nan
CHEMBL1326010 22336 16 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 318 3 1 4 3.7 Cc1ccc(C)c(S(=O)(=O)Nc2ccc3scnc3c2)c1 nan
11958608 22490 0 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 8 2 7 5.2 C=CCCC(=O)Nc1nc(C)c(-c2csc(Nc3cccc(OC)c3)n2)s1 nan
CHEMBL1327451 22490 0 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 8 2 7 5.2 C=CCCC(=O)Nc1nc(C)c(-c2csc(Nc3cccc(OC)c3)n2)s1 nan
1280304 22866 9 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 4 3 6 4.8 O=C(/C=C/c1ccco1)NC(=S)Nc1ccc(O)c(-c2nc3ccccc3s2)c1 nan
CHEMBL1330510 22866 9 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 4 3 6 4.8 O=C(/C=C/c1ccco1)NC(=S)Nc1ccc(O)c(-c2nc3ccccc3s2)c1 nan
655127 23268 10 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 289 5 2 7 2.3 Cc1cc(C)n(-c2nc(NC(C)C)nc(NC(C)C)n2)n1 nan
CHEMBL1333565 23268 10 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 289 5 2 7 2.3 Cc1cc(C)n(-c2nc(NC(C)C)nc(NC(C)C)n2)n1 nan
460749 23331 9 None -7 6 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 1 0 7 0.7 Cn1nc(-c2ccc(Cl)cc2)nc2c(=O)n(C)c(=O)nc1-2 nan
CHEMBL1334062 23331 9 None -7 6 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 1 0 7 0.7 Cn1nc(-c2ccc(Cl)cc2)nc2c(=O)n(C)c(=O)nc1-2 nan
2294485 23682 9 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 2 7 3.9 COc1ccc(-c2csc(NC(=S)NC(=O)/C=C/c3ccco3)n2)cc1OC nan
CHEMBL1336887 23682 9 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 2 7 3.9 COc1ccc(-c2csc(NC(=S)NC(=O)/C=C/c3ccco3)n2)cc1OC nan
3719993 23866 14 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 498 6 1 8 4.2 COc1ccc(C2c3c(ncn(CCN4CCOCC4)c3=N)Oc3ccc4ccccc4c32)cc1OC nan
CHEMBL1338432 23866 14 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 498 6 1 8 4.2 COc1ccc(C2c3c(ncn(CCN4CCOCC4)c3=N)Oc3ccc4ccccc4c32)cc1OC nan
712393 24308 12 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 336 4 1 5 4.3 Oc1ccccc1-c1nnc(COc2ccc(Cl)cc2Cl)o1 nan
CHEMBL1342416 24308 12 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 336 4 1 5 4.3 Oc1ccccc1-c1nnc(COc2ccc(Cl)cc2Cl)o1 nan
1472225 24525 10 None -3 7 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 6 1 4 3.9 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 nan
CHEMBL1344225 24525 10 None -3 7 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 6 1 4 3.9 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 nan
660526 24571 8 None 12 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 6 0 9 1.5 CCOC(=O)Cn1c(=O)c2c(nc(N3CCCCC3)n2Cc2ccccc2)n(C)c1=O nan
CHEMBL1344621 24571 8 None 12 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 6 0 9 1.5 CCOC(=O)Cn1c(=O)c2c(nc(N3CCCCC3)n2Cc2ccccc2)n(C)c1=O nan
658229 24961 13 None 25 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 4 0 8 2.7 COC(=O)CSc1nc2sc3c(c2c(=O)n1-c1ccccc1)CCN(C)C3 nan
CHEMBL1347853 24961 13 None 25 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 4 0 8 2.7 COC(=O)CSc1nc2sc3c(c2c(=O)n1-c1ccccc1)CCN(C)C3 nan
4110386 25291 6 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 9 2 4 4.6 COc1ccc(CCNC(=O)CC(c2ccccc2)c2cccc(C)c2O)cc1OC nan
CHEMBL1350719 25291 6 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 9 2 4 4.6 COc1ccc(CCNC(=O)CC(c2ccccc2)c2cccc(C)c2O)cc1OC nan
5899874 26274 10 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 239 5 0 3 3.4 CCCCCN1C=CC=C/C1=C\C=C(C#N)C#N nan
CHEMBL1360263 26274 10 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 239 5 0 3 3.4 CCCCCN1C=CC=C/C1=C\C=C(C#N)C#N nan
663277 26579 14 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 264 1 1 4 2.9 N#Cc1c(N)nc2c(c1-c1ccncc1)CCCCC2 nan
CHEMBL1362909 26579 14 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 264 1 1 4 2.9 N#Cc1c(N)nc2c(c1-c1ccncc1)CCCCC2 nan
2765288 27351 13 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 306 3 0 3 4.9 N#Cc1ccc(-c2ccc(F)cc2)nc1Sc1ccccc1 nan
CHEMBL1369322 27351 13 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 306 3 0 3 4.9 N#Cc1ccc(-c2ccc(F)cc2)nc1Sc1ccccc1 nan
2928110 27989 8 None 25 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 290 3 1 5 2.7 CCOC(=O)C1=C(C)OC(N)=C(C#N)C1C1CCCCC1 nan
CHEMBL1373766 27989 8 None 25 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 290 3 1 5 2.7 CCOC(=O)C1=C(C)OC(N)=C(C#N)C1C1CCCCC1 nan
3236129 28856 13 None 31 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 4 1 6 3.7 Cc1cc(NC(=O)c2ccc(S(=O)(=O)N3CCCC3)cc2)nc2c1c(=O)oc1ccccc12 nan
CHEMBL1381093 28856 13 None 31 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 4 1 6 3.7 Cc1cc(NC(=O)c2ccc(S(=O)(=O)N3CCCC3)cc2)nc2c1c(=O)oc1ccccc12 nan
73453 29388 22 None -117 16 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
CHEMBL1385840 29388 22 None -117 16 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
5714708 30241 4 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 5 2 5 3.4 COC(=O)c1sc(-c2ccc(Cl)cc2)cc1NC(=O)/C=C/C(=O)O nan
CHEMBL1392791 30241 4 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 5 2 5 3.4 COC(=O)c1sc(-c2ccc(Cl)cc2)cc1NC(=O)/C=C/C(=O)O nan
653302 30348 2 None 25 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 7 1 5 5.5 CCOc1ccc2nc(O)c(CN(Cc3ccco3)C(=O)c3ccc(Br)cc3)cc2c1 nan
CHEMBL1393731 30348 2 None 25 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 7 1 5 5.5 CCOc1ccc2nc(O)c(CN(Cc3ccco3)C(=O)c3ccc(Br)cc3)cc2c1 nan
2086771 31097 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 7 1 4 4.0 CC(=O)Nc1ccc(SCC(=O)N(CCC#N)c2ccc(C)cc2)cc1 nan
CHEMBL1401882 31097 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 7 1 4 4.0 CC(=O)Nc1ccc(SCC(=O)N(CCC#N)c2ccc(C)cc2)cc1 nan
3492160 31608 13 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 4 0 4 5.8 Clc1ccc(CSc2snnc2-c2ccccc2)c(Cl)c1 nan
CHEMBL1406696 31608 13 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 4 0 4 5.8 Clc1ccc(CSc2snnc2-c2ccccc2)c(Cl)c1 nan
135449491 33182 1 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 467 8 2 9 3.1 CN(C)c1ccc(NC(=O)CSCc2nc(O)c3nnn(Cc4ccc(F)cc4)c3n2)cc1 nan
CHEMBL1419679 33182 1 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 467 8 2 9 3.1 CN(C)c1ccc(NC(=O)CSCc2nc(O)c3nnn(Cc4ccc(F)cc4)c3n2)cc1 nan
54680929 33948 11 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 2 2 6 2.7 Cc1csc(NC(=O)c2c(O)c3cccc4c3n(c2=O)CCC4)n1 nan
CHEMBL1426103 33948 11 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 2 2 6 2.7 Cc1csc(NC(=O)c2c(O)c3cccc4c3n(c2=O)CCC4)n1 nan
12005819 36526 9 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 5 0 8 3.9 Cc1cc(C)nc(SCc2cc(=O)c(OC(=O)c3ccc(Br)o3)co2)n1 nan
CHEMBL1449816 36526 9 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 5 0 8 3.9 Cc1cc(C)nc(SCc2cc(=O)c(OC(=O)c3ccc(Br)o3)co2)n1 nan
3244421 37081 15 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 7 1 5 4.0 CCOC(=O)C1=C(c2ccccc2)N(C)C(=O)NC1c1ccc(OC(F)F)c(OC)c1 nan
CHEMBL1454196 37081 15 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 7 1 5 4.0 CCOC(=O)C1=C(c2ccccc2)N(C)C(=O)NC1c1ccc(OC(F)F)c(OC)c1 nan
645800 37186 5 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 9 1 9 4.2 CCOC(=O)Cn1nnnc1C(C(C)C)N(Cc1cc2c(C)cc(C)cc2nc1O)C1CCCC1 nan
CHEMBL1455108 37186 5 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 9 1 9 4.2 CCOC(=O)Cn1nnnc1C(C(C)C)N(Cc1cc2c(C)cc(C)cc2nc1O)C1CCCC1 nan
710950 37511 21 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 306 3 0 6 2.0 c1ccc(N2CCN(c3nnnn3-c3ccccc3)CC2)cc1 nan
CHEMBL1458035 37511 21 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 306 3 0 6 2.0 c1ccc(N2CCN(c3nnnn3-c3ccccc3)CC2)cc1 nan
661708 37667 14 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 464 4 1 8 2.8 Cc1ccc(S(=O)(=O)c2cc3c(=O)n4cccc(C)c4nc3n(CC3CCCO3)c2=N)cc1 nan
CHEMBL1459372 37667 14 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 464 4 1 8 2.8 Cc1ccc(S(=O)(=O)c2cc3c(=O)n4cccc(C)c4nc3n(CC3CCCO3)c2=N)cc1 nan
3647020 37841 11 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 494 8 1 6 3.7 CN(CC(CC(=O)Nc1nncs1)c1ccccc1)S(=O)(=O)c1ccc(Br)cc1 nan
CHEMBL1460803 37841 11 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 494 8 1 6 3.7 CN(CC(CC(=O)Nc1nncs1)c1ccccc1)S(=O)(=O)c1ccc(Br)cc1 nan
7161174 38521 4 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 339 4 1 7 0.2 COc1cccc(NS(=O)(=O)c2c(C)n(C)c(=O)n(C)c2=O)c1 nan
CHEMBL1466394 38521 4 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 339 4 1 7 0.2 COc1cccc(NS(=O)(=O)c2c(C)n(C)c(=O)n(C)c2=O)c1 nan
2082741 39169 6 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 4 1 5 4.1 N#Cc1ccc(NC(=O)c2nc(-c3ccccc3)n(-c3ccccc3)n2)cc1 nan
CHEMBL1471830 39169 6 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 4 1 5 4.1 N#Cc1ccc(NC(=O)c2nc(-c3ccccc3)n(-c3ccccc3)n2)cc1 nan
54677987 40535 10 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 6 2 4 4.4 O=C(Cc1c(O)nc2ccccc2c1O)N(Cc1ccccc1)Cc1ccccc1 nan
CHEMBL1485451 40535 10 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 6 2 4 4.4 O=C(Cc1c(O)nc2ccccc2c1O)N(Cc1ccccc1)Cc1ccccc1 nan
5739060 40591 14 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 5 1 5 3.6 Cc1ccc(C(=O)C2=C(O)C(=O)N(Cc3cccnc3)C2c2ccccn2)cc1 nan
CHEMBL1485925 40591 14 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 5 1 5 3.6 Cc1ccc(C(=O)C2=C(O)C(=O)N(Cc3cccnc3)C2c2ccccn2)cc1 nan
3236790 41116 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 457 6 1 6 3.0 CCn1cc(C(=O)NCc2ccco2)c(=O)c2cc(S(=O)(=O)N3CCC(C)CC3)ccc21 nan
CHEMBL1490036 41116 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 457 6 1 6 3.0 CCn1cc(C(=O)NCc2ccco2)c(=O)c2cc(S(=O)(=O)N3CCC(C)CC3)ccc21 nan
660206 41172 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 328 2 1 4 4.4 COc1ccc(C2C(C#N)=C(C)N=C3C2=C(O)c2ccccc23)cc1 nan
CHEMBL1490456 41172 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 328 2 1 4 4.4 COc1ccc(C2C(C#N)=C(C)N=C3C2=C(O)c2ccccc23)cc1 nan
2188092 41576 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 316 8 0 4 4.4 CCOc1cc(C=O)ccc1OCCSc1ccc(C)cc1 nan
CHEMBL1493478 41576 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 316 8 0 4 4.4 CCOc1cc(C=O)ccc1OCCSc1ccc(C)cc1 nan
3243693 41739 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 270 2 1 3 3.5 Cc1ccc(NC(=O)c2noc3c2CCCCC3)cc1 nan
CHEMBL1495119 41739 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 270 2 1 3 3.5 Cc1ccc(NC(=O)c2noc3c2CCCCC3)cc1 nan
975392 42211 9 None 1 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 1 1 2 4.3 Cc1cc(Br)c2nc3c(c(C(=O)O)c2c1)CCCCC3 nan
CHEMBL1499411 42211 9 None 1 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 1 1 2 4.3 Cc1cc(Br)c2nc3c(c(C(=O)O)c2c1)CCCCC3 nan
3661786 42275 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 5 2 3 3.8 Cc1ccc(S(=O)(=O)N2CCCCC2)cc1NC(=O)Cc1c[nH]c2ccccc12 nan
CHEMBL1499998 42275 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 5 2 3 3.8 Cc1ccc(S(=O)(=O)N2CCCCC2)cc1NC(=O)Cc1c[nH]c2ccccc12 nan
3107134 42602 2 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 521 6 3 7 3.2 COc1ccc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)c3ccc(Br)cc3)cc2)nn1 nan
CHEMBL1502902 42602 2 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 521 6 3 7 3.2 COc1ccc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)c3ccc(Br)cc3)cc2)nn1 nan
659306 43949 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 313 7 2 5 2.8 CCN(CC)CCNc1[nH]cnc2c3cc(OC)ccc3nc1-2 nan
CHEMBL1516678 43949 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 313 7 2 5 2.8 CCN(CC)CCNc1[nH]cnc2c3cc(OC)ccc3nc1-2 nan
686157 43956 14 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 263 4 1 4 2.1 O=C(COc1ccc(Cl)cc1)Nc1ncccn1 nan
CHEMBL1516735 43956 14 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 263 4 1 4 2.1 O=C(COc1ccc(Cl)cc1)Nc1ncccn1 nan
3240692 44121 11 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 2 1 4 4.0 O=C(Nc1cccc(Cl)c1)c1ccc2c(=O)n3c(nc2c1)CCCCC3 nan
CHEMBL1518405 44121 11 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 2 1 4 4.0 O=C(Nc1cccc(Cl)c1)c1ccc2c(=O)n3c(nc2c1)CCCCC3 nan
3236043 44340 9 None 5 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 8 1 6 2.8 COc1cc(NC(=O)CN2CCN(S(=O)(=O)c3ccc(C(C)C)cc3)CC2)cc(OC)c1 nan
CHEMBL1520338 44340 9 None 5 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 8 1 6 2.8 COc1cc(NC(=O)CN2CCN(S(=O)(=O)c3ccc(C(C)C)cc3)CC2)cc(OC)c1 nan
1355435 45227 11 None 22 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 2 0 4 3.3 Cc1cn(S(=O)(=O)c2ccc(Br)c3ccccc23)cn1 nan
CHEMBL1528299 45227 11 None 22 2 Human 6.0 pPotency