Ligand source activities (1 row/activity)





Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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377 2758 None 42 Human Functional pEC50 = 9.9 9.9 -3 10
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acsmedchemlett.2c00052
425 2758 None 42 Human Functional pEC50 = 9.9 9.9 -3 10
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acsmedchemlett.2c00052
448222 2758 None 42 Human Functional pEC50 = 9.9 9.9 -3 10
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acsmedchemlett.2c00052
CHEMBL464859 2758 None 42 Human Functional pEC50 = 9.9 9.9 -3 10
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acsmedchemlett.2c00052
3035850 951 None 50 Mouse Functional pEC50 = 9.8 9.8 14 2
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISAAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/jm4007966
3035850.0 951 None 50 Mouse Functional pEC50 = 9.8 9.8 14 2
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISAAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/jm4007966
457 951 None 50 Mouse Functional pEC50 = 9.8 9.8 14 2
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISAAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/jm4007966
CHEMBL431733 951 None 50 Mouse Functional pEC50 = 9.8 9.8 14 2
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISAAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/jm4007966
DB12885 951 None 50 Mouse Functional pEC50 = 9.8 9.8 14 2
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISAAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/jm4007966
118730350 118202 None 0 Mouse Functional pEC50 = 9.6 9.6 1 2
Agonist activity at mouse A3 adenosine receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 15 minsAgonist activity at mouse A3 adenosine receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 15 mins
ChEMBL 424 3 4 9 0.4 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(C#Cc4cccs4)nc31)[C@H](O)[C@@H]2O 10.1021/jm501021n
CHEMBL3407783 118202 None 0 Mouse Functional pEC50 = 9.6 9.6 1 2
Agonist activity at mouse A3 adenosine receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 15 minsAgonist activity at mouse A3 adenosine receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 15 mins
ChEMBL 424 3 4 9 0.4 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(C#Cc4cccs4)nc31)[C@H](O)[C@@H]2O 10.1021/jm501021n
154730931 171626 None 1 Human Functional pEC50 = 9.6 9.6 - 1
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay
ChEMBL 462 4 3 8 1.9 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N(C)c4cccc(Cl)c4)nc(Cl)nc31)[C@H](O)[C@@H]2O 10.1021/acs.jmedchem.8b00435
CHEMBL4464176 171626 None 1 Human Functional pEC50 = 9.6 9.6 - 1
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay
ChEMBL 462 4 3 8 1.9 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N(C)c4cccc(Cl)c4)nc(Cl)nc31)[C@H](O)[C@@H]2O 10.1021/acs.jmedchem.8b00435
168278076 190361 None 0 Human Functional pEC50 = 9.5 9.5 3 2
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 295 2 0 6 1.9 Cn1nc(-c2ccccc2)c2cnnc(N3CCOCC3)c21 10.1021/acsmedchemlett.2c00052
CHEMBL5175347 190361 None 0 Human Functional pEC50 = 9.5 9.5 3 2
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 295 2 0 6 1.9 Cn1nc(-c2ccccc2)c2cnnc(N3CCOCC3)c21 10.1021/acsmedchemlett.2c00052
91799687 118192 None 0 Mouse Functional pEC50 = 9.5 9.5 4 2
Agonist activity at mouse A3 adenosine receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 15 minsAgonist activity at mouse A3 adenosine receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 15 mins
ChEMBL 420 3 4 10 -0.9 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(C#Cc4cnccn4)nc31)[C@H](O)[C@@H]2O 10.1021/jm501021n
CHEMBL3407774 118192 None 0 Mouse Functional pEC50 = 9.5 9.5 4 2
Agonist activity at mouse A3 adenosine receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 15 minsAgonist activity at mouse A3 adenosine receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 15 mins
ChEMBL 420 3 4 10 -0.9 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(C#Cc4cnccn4)nc31)[C@H](O)[C@@H]2O 10.1021/jm501021n
123683 3121 None 46 Human Functional pEC50 = 9.4 9.4 67 5
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.8b00435
422 3121 None 46 Human Functional pEC50 = 9.4 9.4 67 5
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.8b00435
CHEMBL119709 3121 None 46 Human Functional pEC50 = 9.4 9.4 67 5
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.8b00435
DB05511 3121 None 46 Human Functional pEC50 = 9.4 9.4 67 5
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.8b00435
118730350 118202 None 0 Human Functional pEC50 = 9.4 9.4 -1 2
Agonist activity at human recombinant A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 15 minsAgonist activity at human recombinant A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 15 mins
ChEMBL 424 3 4 9 0.4 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(C#Cc4cccs4)nc31)[C@H](O)[C@@H]2O 10.1021/jm501021n
CHEMBL3407783 118202 None 0 Human Functional pEC50 = 9.4 9.4 -1 2
Agonist activity at human recombinant A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 15 minsAgonist activity at human recombinant A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 15 mins
ChEMBL 424 3 4 9 0.4 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(C#Cc4cccs4)nc31)[C@H](O)[C@@H]2O 10.1021/jm501021n
3035850 951 None 50 Mouse Functional pEC50 = 9.3 9.3 14 2
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forsolkin addition measured after 15 mins by immunoassayAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forsolkin addition measured after 15 mins by immunoassay
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/acs.jmedchem.5b01998
3035850.0 951 None 50 Mouse Functional pEC50 = 9.3 9.3 14 2
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forsolkin addition measured after 15 mins by immunoassayAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forsolkin addition measured after 15 mins by immunoassay
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/acs.jmedchem.5b01998
457 951 None 50 Mouse Functional pEC50 = 9.3 9.3 14 2
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forsolkin addition measured after 15 mins by immunoassayAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forsolkin addition measured after 15 mins by immunoassay
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/acs.jmedchem.5b01998
CHEMBL431733 951 None 50 Mouse Functional pEC50 = 9.3 9.3 14 2
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forsolkin addition measured after 15 mins by immunoassayAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forsolkin addition measured after 15 mins by immunoassay
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/acs.jmedchem.5b01998
DB12885 951 None 50 Mouse Functional pEC50 = 9.3 9.3 14 2
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forsolkin addition measured after 15 mins by immunoassayAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forsolkin addition measured after 15 mins by immunoassay
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/acs.jmedchem.5b01998
168285237 191861 None 0 Human Functional pEC50 = 9.3 9.3 3 2
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 315 4 1 5 3.6 Cn1nc2c(NCc3ccccc3)nncc2c1-c1ccccc1 10.1021/acsmedchemlett.2c00052
CHEMBL5197567 191861 None 0 Human Functional pEC50 = 9.3 9.3 3 2
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 315 4 1 5 3.6 Cn1nc2c(NCc3ccccc3)nncc2c1-c1ccccc1 10.1021/acsmedchemlett.2c00052
123683 3121 None 46 Human Functional pEC50 = 9.3 9.3 67 5
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1039/C3MD00364G
422 3121 None 46 Human Functional pEC50 = 9.3 9.3 67 5
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1039/C3MD00364G
CHEMBL119709 3121 None 46 Human Functional pEC50 = 9.3 9.3 67 5
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1039/C3MD00364G
DB05511 3121 None 46 Human Functional pEC50 = 9.3 9.3 67 5
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1039/C3MD00364G
168281259 190873 None 0 Human Functional pEC50 = 9.3 9.3 2 2
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 295 2 0 6 1.9 Cn1nc2c(N3CCOCC3)nncc2c1-c1ccccc1 10.1021/acsmedchemlett.2c00052
CHEMBL5183118 190873 None 0 Human Functional pEC50 = 9.3 9.3 2 2
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 295 2 0 6 1.9 Cn1nc2c(N3CCOCC3)nncc2c1-c1ccccc1 10.1021/acsmedchemlett.2c00052
118730351 118203 None 3 Mouse Functional pEC50 = 9.2 9.2 57 2
Agonist activity at mouse A3 adenosine receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 15 minsAgonist activity at mouse A3 adenosine receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 15 mins
ChEMBL 458 3 4 9 1.0 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(C#Cc4ccc(Cl)s4)nc31)[C@H](O)[C@@H]2O 10.1021/jm501021n
CHEMBL3407784 118203 None 3 Mouse Functional pEC50 = 9.2 9.2 57 2
Agonist activity at mouse A3 adenosine receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 15 minsAgonist activity at mouse A3 adenosine receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 15 mins
ChEMBL 458 3 4 9 1.0 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(C#Cc4ccc(Cl)s4)nc31)[C@H](O)[C@@H]2O 10.1021/jm501021n
76336527 106119 None 0 Human Functional pEC50 = 9.2 9.2 501 4
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 433 5 5 10 0.0 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cccc(Cl)c4)nc(N)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
CHEMBL3133161 106119 None 0 Human Functional pEC50 = 9.2 9.2 501 4
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 433 5 5 10 0.0 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cccc(Cl)c4)nc(N)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
9893136 98813 None 0 Human Functional pEC50 = 9.2 9.2 208 3
Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorStimulation of [35S]GTP-gamma-S, against human adenosine A3 receptor
ChEMBL 527 5 4 8 2.0 OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(I)c4)nc(Cl)nc31)[C@H](O)[C@@H]2O 10.1021/jm9905965
CHEMBL27809 98813 None 0 Human Functional pEC50 = 9.2 9.2 208 3
Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorStimulation of [35S]GTP-gamma-S, against human adenosine A3 receptor
ChEMBL 527 5 4 8 2.0 OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(I)c4)nc(Cl)nc31)[C@H](O)[C@@H]2O 10.1021/jm9905965
9805713 162941 None 0 Human Functional pEC50 = 9.2 9.2 309 3
Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorStimulation of [35S]GTP-gamma-S, against human adenosine A3 receptor
ChEMBL 493 5 4 8 1.3 OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(I)c4)ncnc31)[C@H](O)[C@@H]2O 10.1021/jm9905965
CHEMBL417292 162941 None 0 Human Functional pEC50 = 9.2 9.2 309 3
Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorStimulation of [35S]GTP-gamma-S, against human adenosine A3 receptor
ChEMBL 493 5 4 8 1.3 OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(I)c4)ncnc31)[C@H](O)[C@@H]2O 10.1021/jm9905965
57523714 76721 None 0 Human Functional pEC50 = 9.1 9.1 - 1
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay
ChEMBL 528 5 4 8 2.5 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(Cl)c4)nc(C#Cc4ccccc4)nc31)[C@H](O)[C@@H]2O 10.1021/acs.jmedchem.8b00435
CHEMBL2064653 76721 None 0 Human Functional pEC50 = 9.1 9.1 - 1
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay
ChEMBL 528 5 4 8 2.5 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(Cl)c4)nc(C#Cc4ccccc4)nc31)[C@H](O)[C@@H]2O 10.1021/acs.jmedchem.8b00435
168281767 191032 None 0 Human Functional pEC50 = 9.0 9.0 7 2
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 281 4 1 5 3.1 CC(C)c1nn(C)c2c(NCc3ccccc3)nncc12 10.1021/acsmedchemlett.2c00052
CHEMBL5185411 191032 None 0 Human Functional pEC50 = 9.0 9.0 7 2
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 281 4 1 5 3.1 CC(C)c1nn(C)c2c(NCc3ccccc3)nncc12 10.1021/acsmedchemlett.2c00052
123683 3121 None 46 Human Functional pEC50 = 9 9.0 67 5
Inhibition of isoproterenol-stimulated cAMP accumulation in HEK 293 cells expressing human Adenosine A3 receptorInhibition of isoproterenol-stimulated cAMP accumulation in HEK 293 cells expressing human Adenosine A3 receptor
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/jm0255724
422 3121 None 46 Human Functional pEC50 = 9 9.0 67 5
Inhibition of isoproterenol-stimulated cAMP accumulation in HEK 293 cells expressing human Adenosine A3 receptorInhibition of isoproterenol-stimulated cAMP accumulation in HEK 293 cells expressing human Adenosine A3 receptor
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/jm0255724
CHEMBL119709 3121 None 46 Human Functional pEC50 = 9 9.0 67 5
Inhibition of isoproterenol-stimulated cAMP accumulation in HEK 293 cells expressing human Adenosine A3 receptorInhibition of isoproterenol-stimulated cAMP accumulation in HEK 293 cells expressing human Adenosine A3 receptor
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/jm0255724
DB05511 3121 None 46 Human Functional pEC50 = 9 9.0 67 5
Inhibition of isoproterenol-stimulated cAMP accumulation in HEK 293 cells expressing human Adenosine A3 receptorInhibition of isoproterenol-stimulated cAMP accumulation in HEK 293 cells expressing human Adenosine A3 receptor
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/jm0255724
168293746 192262 None 0 Human Functional pEC50 = 8.9 8.9 2 2
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 281 4 1 5 3.1 CC(C)c1c2cnnc(NCc3ccccc3)c2nn1C 10.1021/acsmedchemlett.2c00052
CHEMBL5203865 192262 None 0 Human Functional pEC50 = 8.9 8.9 2 2
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 281 4 1 5 3.1 CC(C)c1c2cnnc(NCc3ccccc3)c2nn1C 10.1021/acsmedchemlett.2c00052
3035850 951 None 50 Human Functional pEC50 = 8.9 8.9 -14 2
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMPAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1016/j.bmcl.2008.01.070
3035850.0 951 None 50 Human Functional pEC50 = 8.9 8.9 -14 2
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMPAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1016/j.bmcl.2008.01.070
457 951 None 50 Human Functional pEC50 = 8.9 8.9 -14 2
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMPAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1016/j.bmcl.2008.01.070
CHEMBL431733 951 None 50 Human Functional pEC50 = 8.9 8.9 -14 2
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMPAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1016/j.bmcl.2008.01.070
DB12885 951 None 50 Human Functional pEC50 = 8.9 8.9 -14 2
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMPAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1016/j.bmcl.2008.01.070
57523213 2673 None 20 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 30 mins prior to forskolin-stimulation measured after 15 mins by enzyme immunoassayAgonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 30 mins prior to forskolin-stimulation measured after 15 mins by enzyme immunoassay
ChEMBL 564 5 4 8 2.8 CNC(=O)[C@@]12C[C@@H]1[C@H]([C@@H]([C@@H]2O)O)n1cnc2c1nc(C#Cc1ccc(c(c1)F)F)nc2NCc1cccc(c1)Cl 10.1021/jm300396n
8421 2673 None 20 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 30 mins prior to forskolin-stimulation measured after 15 mins by enzyme immunoassayAgonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 30 mins prior to forskolin-stimulation measured after 15 mins by enzyme immunoassay
ChEMBL 564 5 4 8 2.8 CNC(=O)[C@@]12C[C@@H]1[C@H]([C@@H]([C@@H]2O)O)n1cnc2c1nc(C#Cc1ccc(c(c1)F)F)nc2NCc1cccc(c1)Cl 10.1021/jm300396n
CHEMBL2064657 2673 None 20 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 30 mins prior to forskolin-stimulation measured after 15 mins by enzyme immunoassayAgonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 30 mins prior to forskolin-stimulation measured after 15 mins by enzyme immunoassay
ChEMBL 564 5 4 8 2.8 CNC(=O)[C@@]12C[C@@H]1[C@H]([C@@H]([C@@H]2O)O)n1cnc2c1nc(C#Cc1ccc(c(c1)F)F)nc2NCc1cccc(c1)Cl 10.1021/jm300396n
3035850 951 None 50 Human Functional pEC50 = 8.9 8.9 -14 2
Agonist activity at human A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin stimulated cAMP formation incubated for 45 mins followed by forskolin stimulation and measured after 15 mins by liquid scintillation spectrometry analysisAgonist activity at human A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin stimulated cAMP formation incubated for 45 mins followed by forskolin stimulation and measured after 15 mins by liquid scintillation spectrometry analysis
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/acs.jmedchem.1c00239
3035850.0 951 None 50 Human Functional pEC50 = 8.9 8.9 -14 2
Agonist activity at human A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin stimulated cAMP formation incubated for 45 mins followed by forskolin stimulation and measured after 15 mins by liquid scintillation spectrometry analysisAgonist activity at human A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin stimulated cAMP formation incubated for 45 mins followed by forskolin stimulation and measured after 15 mins by liquid scintillation spectrometry analysis
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/acs.jmedchem.1c00239
457 951 None 50 Human Functional pEC50 = 8.9 8.9 -14 2
Agonist activity at human A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin stimulated cAMP formation incubated for 45 mins followed by forskolin stimulation and measured after 15 mins by liquid scintillation spectrometry analysisAgonist activity at human A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin stimulated cAMP formation incubated for 45 mins followed by forskolin stimulation and measured after 15 mins by liquid scintillation spectrometry analysis
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/acs.jmedchem.1c00239
CHEMBL431733 951 None 50 Human Functional pEC50 = 8.9 8.9 -14 2
Agonist activity at human A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin stimulated cAMP formation incubated for 45 mins followed by forskolin stimulation and measured after 15 mins by liquid scintillation spectrometry analysisAgonist activity at human A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin stimulated cAMP formation incubated for 45 mins followed by forskolin stimulation and measured after 15 mins by liquid scintillation spectrometry analysis
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/acs.jmedchem.1c00239
DB12885 951 None 50 Human Functional pEC50 = 8.9 8.9 -14 2
Agonist activity at human A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin stimulated cAMP formation incubated for 45 mins followed by forskolin stimulation and measured after 15 mins by liquid scintillation spectrometry analysisAgonist activity at human A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin stimulated cAMP formation incubated for 45 mins followed by forskolin stimulation and measured after 15 mins by liquid scintillation spectrometry analysis
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/acs.jmedchem.1c00239
44359213 119516 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 352 3 4 8 -0.5 CNC(=O)C12CC1C(n1cnc3c(NC)nc(Cl)nc31)C(O)C2O 10.1021/jm020211+
CHEMBL345076 119516 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 352 3 4 8 -0.5 CNC(=O)C12CC1C(n1cnc3c(NC)nc(Cl)nc31)C(O)C2O 10.1021/jm020211+
91799687 118192 None 0 Human Functional pEC50 = 8.8 8.8 -4 2
Agonist activity at human recombinant A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 15 minsAgonist activity at human recombinant A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 15 mins
ChEMBL 420 3 4 10 -0.9 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(C#Cc4cnccn4)nc31)[C@H](O)[C@@H]2O 10.1021/jm501021n
CHEMBL3407774 118192 None 0 Human Functional pEC50 = 8.8 8.8 -4 2
Agonist activity at human recombinant A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 15 minsAgonist activity at human recombinant A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 15 mins
ChEMBL 420 3 4 10 -0.9 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(C#Cc4cnccn4)nc31)[C@H](O)[C@@H]2O 10.1021/jm501021n
122188579 123251 None 0 Human Functional pEC50 = 8.8 8.8 - 1
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of cAMP productionAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of cAMP production
ChEMBL 471 4 4 8 2.0 CCNc1cc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)NC)C[C@H]12 10.1021/acsmedchemlett.5b00150
CHEMBL3612940 123251 None 0 Human Functional pEC50 = 8.8 8.8 - 1
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of cAMP productionAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of cAMP production
ChEMBL 471 4 4 8 2.0 CCNc1cc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)NC)C[C@H]12 10.1021/acsmedchemlett.5b00150
76311194 106102 None 0 Human Functional pEC50 = 8.8 8.8 100 4
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 525 5 5 10 -0.0 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)nc(N)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
CHEMBL3133078 106102 None 0 Human Functional pEC50 = 8.8 8.8 100 4
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 525 5 5 10 -0.0 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)nc(N)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
44387284 132478 None 0 Human Functional pEC50 = 8.8 8.8 - 1
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 568 8 6 11 -0.4 CNCC(=O)NC[C@H]1O[C@@H](n2cnc3c(NCc4ccc(N)c(I)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm020211+
CHEMBL369744 132478 None 0 Human Functional pEC50 = 8.8 8.8 - 1
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 568 8 6 11 -0.4 CNCC(=O)NC[C@H]1O[C@@H](n2cnc3c(NCc4ccc(N)c(I)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm020211+
44436082 148008 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at human adenosine A3 receptor after 15 to 30 minsAgonist activity at human adenosine A3 receptor after 15 to 30 mins
ChEMBL 524 6 3 9 1.1 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)ncnc32)[C@H](OC)[C@@H]1O 10.1016/j.bmc.2007.05.056
CHEMBL393362 148008 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at human adenosine A3 receptor after 15 to 30 minsAgonist activity at human adenosine A3 receptor after 15 to 30 mins
ChEMBL 524 6 3 9 1.1 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)ncnc32)[C@H](OC)[C@@H]1O 10.1016/j.bmc.2007.05.056
3086599 904 None 36 Human Functional pEC50 = 8 8.0 -3 6
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 499 10 6 11 -0.2 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N 10.1039/C3MD00364G
375 904 None 36 Human Functional pEC50 = 8 8.0 -3 6
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 499 10 6 11 -0.2 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N 10.1039/C3MD00364G
424 904 None 36 Human Functional pEC50 = 8 8.0 -3 6
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 499 10 6 11 -0.2 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N 10.1039/C3MD00364G
CHEMBL331372 904 None 36 Human Functional pEC50 = 8 8.0 -3 6
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 499 10 6 11 -0.2 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N 10.1039/C3MD00364G
76336525 106112 None 0 Human Functional pEC50 = 8 8.0 158 3
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 337 4 5 10 -1.8 CCNc1nc(N)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O 10.1039/C3MD00364G
CHEMBL3133154 106112 None 0 Human Functional pEC50 = 8 8.0 158 3
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 337 4 5 10 -1.8 CCNc1nc(N)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O 10.1039/C3MD00364G
76336526 106113 None 0 Human Functional pEC50 = 8 8.0 31 3
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 351 5 5 10 -1.4 CCCNc1nc(N)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O 10.1039/C3MD00364G
CHEMBL3133155 106113 None 0 Human Functional pEC50 = 8 8.0 31 3
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 351 5 5 10 -1.4 CCCNc1nc(N)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O 10.1039/C3MD00364G
164619608 185771 None 0 Human Functional pEC50 = 8.0 8.0 2089 2
Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as cAMP level measured after 35 mins by cAMP enzyme immunoassayAgonist activity at human adenosine A3 receptor transfected in CHO cells assessed as cAMP level measured after 35 mins by cAMP enzyme immunoassay
ChEMBL 433 8 4 9 1.5 OC[C@H]1O[C@@H](n2cnc3c(NCCCCc4ccccc4)nc(Cl)nc32)[C@H](O)[C@@H]1O 10.1016/j.ejmech.2021.113607
CHEMBL4864883 185771 None 0 Human Functional pEC50 = 8.0 8.0 2089 2
Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as cAMP level measured after 35 mins by cAMP enzyme immunoassayAgonist activity at human adenosine A3 receptor transfected in CHO cells assessed as cAMP level measured after 35 mins by cAMP enzyme immunoassay
ChEMBL 433 8 4 9 1.5 OC[C@H]1O[C@@H](n2cnc3c(NCCCCc4ccccc4)nc(Cl)nc32)[C@H](O)[C@@H]1O 10.1016/j.ejmech.2021.113607
168288912 191737 None 0 Human Functional pEC50 = 7 7.0 -812 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 502 7 4 10 1.6 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccccc4Cl)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
CHEMBL5195714 191737 None 0 Human Functional pEC50 = 7 7.0 -812 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 502 7 4 10 1.6 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccccc4Cl)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
76314797 106105 None 0 Human Functional pEC50 = 7 7.0 3 3
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 391 5 5 10 -0.4 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(NC)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
CHEMBL3133081 106105 None 0 Human Functional pEC50 = 7 7.0 3 3
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 391 5 5 10 -0.4 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(NC)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
118732979 118584 None 0 Human Functional pEC50 = 7.0 7.0 -14 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 437 5 3 13 0.0 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CCCO5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
CHEMBL3414945 118584 None 0 Human Functional pEC50 = 7.0 7.0 -14 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 437 5 3 13 0.0 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CCCO5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
2844 283 None 61 Human Functional pEC50 = 6.0 6.0 -1 5
Activity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayActivity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm050968b
60961 283 None 61 Human Functional pEC50 = 6.0 6.0 -1 5
Activity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayActivity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm050968b
60961.0 283 None 61 Human Functional pEC50 = 6.0 6.0 -1 5
Activity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayActivity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm050968b
90 283 None 61 Human Functional pEC50 = 6.0 6.0 -1 5
Activity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayActivity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm050968b
CHEMBL477 283 None 61 Human Functional pEC50 = 6.0 6.0 -1 5
Activity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayActivity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm050968b
DB00640 283 None 61 Human Functional pEC50 = 6.0 6.0 -1 5
Activity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayActivity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm050968b
377 2758 None 42 Human Functional pEC50 = 5.0 5.0 -3 10
Activity against human adenosine A3 receptor H272E mutant expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayActivity against human adenosine A3 receptor H272E mutant expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm050968b
425 2758 None 42 Human Functional pEC50 = 5.0 5.0 -3 10
Activity against human adenosine A3 receptor H272E mutant expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayActivity against human adenosine A3 receptor H272E mutant expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm050968b
448222 2758 None 42 Human Functional pEC50 = 5.0 5.0 -3 10
Activity against human adenosine A3 receptor H272E mutant expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayActivity against human adenosine A3 receptor H272E mutant expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm050968b
CHEMBL464859 2758 None 42 Human Functional pEC50 = 5.0 5.0 -3 10
Activity against human adenosine A3 receptor H272E mutant expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayActivity against human adenosine A3 receptor H272E mutant expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm050968b
67431601 191185 None 0 Human Functional pEC50 = 6.0 6.0 -575 2
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 471 8 4 11 1.0 COc1cccc(CO[C@@H]2CCC[C@H]2Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1 10.1021/acs.jmedchem.2c01414
CHEMBL5187478 191185 None 0 Human Functional pEC50 = 6.0 6.0 -575 2
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 471 8 4 11 1.0 COc1cccc(CO[C@@H]2CCC[C@H]2Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1 10.1021/acs.jmedchem.2c01414
137661670 159430 None 0 Human Functional pEC50 = 7.0 7.0 -1 3
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 509 6 3 12 1.9 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5ccc(Cl)cc5F)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
CHEMBL4100130 159430 None 0 Human Functional pEC50 = 7.0 7.0 -1 3
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 509 6 3 12 1.9 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5ccc(Cl)cc5F)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
23643558 86103 None 0 Human Functional pEC50 = 8.0 8.0 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation
ChEMBL 498 5 0 6 6.1 COc1ccc(-n2cc3c(n2)c(N(C(=O)c2ccccc2)C(=O)c2ccccc2)nc2ccccc23)cc1 10.1021/jm070123v
CHEMBL230854 86103 None 0 Human Functional pEC50 = 8.0 8.0 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation
ChEMBL 498 5 0 6 6.1 COc1ccc(-n2cc3c(n2)c(N(C(=O)c2ccccc2)C(=O)c2ccccc2)nc2ccccc23)cc1 10.1021/jm070123v
11706 1130 None 4 Human Functional pEC50 = 8.0 8.0 - 1
Agonist activity at human A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin stimulated cAMP formation incubated for 45 mins followed by forskolin stimulation and measured after 15 mins by liquid scintillation spectrometry analysisAgonist activity at human A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin stimulated cAMP formation incubated for 45 mins followed by forskolin stimulation and measured after 15 mins by liquid scintillation spectrometry analysis
ChEMBL 266 2 3 8 -0.2 O[C@H]1[C@@H](SC[C@H]1N)n1cnc2c(ncnc12)NC 10.1021/acs.jmedchem.1c00239
156587569 1130 None 4 Human Functional pEC50 = 8.0 8.0 - 1
Agonist activity at human A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin stimulated cAMP formation incubated for 45 mins followed by forskolin stimulation and measured after 15 mins by liquid scintillation spectrometry analysisAgonist activity at human A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin stimulated cAMP formation incubated for 45 mins followed by forskolin stimulation and measured after 15 mins by liquid scintillation spectrometry analysis
ChEMBL 266 2 3 8 -0.2 O[C@H]1[C@@H](SC[C@H]1N)n1cnc2c(ncnc12)NC 10.1021/acs.jmedchem.1c00239
CHEMBL5075606 1130 None 4 Human Functional pEC50 = 8.0 8.0 - 1
Agonist activity at human A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin stimulated cAMP formation incubated for 45 mins followed by forskolin stimulation and measured after 15 mins by liquid scintillation spectrometry analysisAgonist activity at human A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin stimulated cAMP formation incubated for 45 mins followed by forskolin stimulation and measured after 15 mins by liquid scintillation spectrometry analysis
ChEMBL 266 2 3 8 -0.2 O[C@H]1[C@@H](SC[C@H]1N)n1cnc2c(ncnc12)NC 10.1021/acs.jmedchem.1c00239
71657835 159831 None 4 Human Functional pEC50 = 5.9 5.9 -7 4
Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assay
ChEMBL 815 15 6 13 6.1 Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.2c00320
CHEMBL4104819 159831 None 4 Human Functional pEC50 = 5.9 5.9 -7 4
Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assay
ChEMBL 815 15 6 13 6.1 Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.2c00320
44579714 187091 None 0 Human Functional pEC50 = 7.9 7.9 - 1
Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated 45 mins before forskolin challenge measured after 15 mins by radioimmunoassay relative to NECAAgonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated 45 mins before forskolin challenge measured after 15 mins by radioimmunoassay relative to NECA
ChEMBL 497 4 3 7 2.6 O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc21 10.1021/jm900426g
CHEMBL490605 187091 None 0 Human Functional pEC50 = 7.9 7.9 - 1
Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated 45 mins before forskolin challenge measured after 15 mins by radioimmunoassay relative to NECAAgonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated 45 mins before forskolin challenge measured after 15 mins by radioimmunoassay relative to NECA
ChEMBL 497 4 3 7 2.6 O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc21 10.1021/jm900426g
137659441 159192 None 0 Human Functional pEC50 = 7.9 7.9 1 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 441 6 3 12 0.6 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(F)c5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
CHEMBL4097468 159192 None 0 Human Functional pEC50 = 7.9 7.9 1 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 441 6 3 12 0.6 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(F)c5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
168287894 191460 None 0 Human Functional pEC50 = 6.9 6.9 -11 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 502 7 4 10 1.6 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccc(Cl)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
CHEMBL5191989 191460 None 0 Human Functional pEC50 = 6.9 6.9 -11 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 502 7 4 10 1.6 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccc(Cl)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
44586227 191563 None 0 Human Functional pEC50 = 4.9 4.9 - 1
Antagonist activity at human adenosine A3 cells expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulationAntagonist activity at human adenosine A3 cells expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation
ChEMBL 433 4 0 9 0.8 CS(=O)(=O)N(c1nc2ccccc2n2c(=O)n(-c3ccccc3)nc12)S(C)(=O)=O 10.1016/j.bmc.2008.04.039
CHEMBL519319 191563 None 0 Human Functional pEC50 = 4.9 4.9 - 1
Antagonist activity at human adenosine A3 cells expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulationAntagonist activity at human adenosine A3 cells expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation
ChEMBL 433 4 0 9 0.8 CS(=O)(=O)N(c1nc2ccccc2n2c(=O)n(-c3ccccc3)nc12)S(C)(=O)=O 10.1016/j.bmc.2008.04.039
137661505 159590 None 0 Human Functional pEC50 = 6.9 6.9 -3 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 815 15 6 13 6.1 Nc1sc(-c2cccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.8b00047
CHEMBL4101850 159590 None 0 Human Functional pEC50 = 6.9 6.9 -3 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 815 15 6 13 6.1 Nc1sc(-c2cccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.8b00047
137650899 157295 None 0 Human Functional pEC50 = 6.9 6.9 -2 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 413 6 3 13 0.0 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5ccco5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
CHEMBL4076003 157295 None 0 Human Functional pEC50 = 6.9 6.9 -2 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 413 6 3 13 0.0 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5ccco5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
76325694 106117 None 0 Human Functional pEC50 = 6.9 6.9 -1 4
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 391 4 5 10 -0.5 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCCCC4)nc(N)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
CHEMBL3133159 106117 None 0 Human Functional pEC50 = 6.9 6.9 -1 4
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 391 4 5 10 -0.5 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCCCC4)nc(N)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
16109362 137892 None 0 Human Functional pEC50 = 5.9 5.9 -48 2
Agonist activity at human A3 adenosine receptor expressed in Flp-In-CHO cells assessed as calcium influx by competitive binding assayAgonist activity at human A3 adenosine receptor expressed in Flp-In-CHO cells assessed as calcium influx by competitive binding assay
ChEMBL 883 20 6 14 4.3 O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O 10.1021/acs.jmedchem.0c02067
CHEMBL375965 137892 None 0 Human Functional pEC50 = 5.9 5.9 -48 2
Agonist activity at human A3 adenosine receptor expressed in Flp-In-CHO cells assessed as calcium influx by competitive binding assayAgonist activity at human A3 adenosine receptor expressed in Flp-In-CHO cells assessed as calcium influx by competitive binding assay
ChEMBL 883 20 6 14 4.3 O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O 10.1021/acs.jmedchem.0c02067
57524978 91302 None 0 Mouse Functional pEC50 = 7.9 7.9 38 2
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISAAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA
ChEMBL 608 6 5 10 1.8 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(Cl)c4)nc(C#Cc4ccc(S(=O)(=O)O)cc4)nc31)[C@H](O)[C@@H]2O 10.1021/jm4007966
CHEMBL2401954 91302 None 0 Mouse Functional pEC50 = 7.9 7.9 38 2
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISAAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA
ChEMBL 608 6 5 10 1.8 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(Cl)c4)nc(C#Cc4ccc(S(=O)(=O)O)cc4)nc31)[C@H](O)[C@@H]2O 10.1021/jm4007966
118732982 118587 None 0 Human Functional pEC50 = 7.9 7.9 -1 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 583 6 3 12 1.7 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5ccccc5I)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
CHEMBL3414948 118587 None 0 Human Functional pEC50 = 7.9 7.9 -1 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 583 6 3 12 1.7 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5ccccc5I)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
2844 283 None 61 Human Functional pEC50 = 7.9 7.9 -1 5
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.2c01414
60961 283 None 61 Human Functional pEC50 = 7.9 7.9 -1 5
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.2c01414
60961.0 283 None 61 Human Functional pEC50 = 7.9 7.9 -1 5
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.2c01414
90 283 None 61 Human Functional pEC50 = 7.9 7.9 -1 5
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.2c01414
CHEMBL477 283 None 61 Human Functional pEC50 = 7.9 7.9 -1 5
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.2c01414
DB00640 283 None 61 Human Functional pEC50 = 7.9 7.9 -1 5
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.2c01414
168279634 191141 None 0 Human Functional pEC50 = 6.9 6.9 -20 3
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 461 6 4 10 1.5 OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccc(Cl)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
CHEMBL5186981 191141 None 0 Human Functional pEC50 = 6.9 6.9 -20 3
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 461 6 4 10 1.5 OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccc(Cl)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
168272212 190540 None 0 Human Functional pEC50 = 6.9 6.9 -3 4
Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assay
ChEMBL 518 10 5 10 1.9 O=C(NCCCCc1ccc(Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)c1ccccc1 10.1021/acs.jmedchem.2c00320
CHEMBL5178142 190540 None 0 Human Functional pEC50 = 6.9 6.9 -3 4
Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assay
ChEMBL 518 10 5 10 1.9 O=C(NCCCCc1ccc(Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)c1ccccc1 10.1021/acs.jmedchem.2c00320
132991435 180904 None 0 Human Functional pEC50 = 6.9 6.9 -141 4
Irreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay
ChEMBL 558 8 5 12 0.8 O=C(NCc1ccc(Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)c1ccc(S(=O)(=O)F)cc1 10.1021/acs.jmedchem.6b01561
CHEMBL4756472 180904 None 0 Human Functional pEC50 = 6.9 6.9 -141 4
Irreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay
ChEMBL 558 8 5 12 0.8 O=C(NCc1ccc(Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)c1ccc(S(=O)(=O)F)cc1 10.1021/acs.jmedchem.6b01561
70695812 73309 None 0 Human Functional pEC50 = 5.9 5.9 -208 3
Agonist activity at human A3A adenosine receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assayAgonist activity at human A3A adenosine receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assay
ChEMBL 375 5 3 7 2.0 O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CC3)C3CC3)nc(Cl)nc21 10.1021/acs.jmedchem.8b01662
CHEMBL2012686 73309 None 0 Human Functional pEC50 = 5.9 5.9 -208 3
Agonist activity at human A3A adenosine receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assayAgonist activity at human A3A adenosine receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assay
ChEMBL 375 5 3 7 2.0 O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CC3)C3CC3)nc(Cl)nc21 10.1021/acs.jmedchem.8b01662
10254700 205984 None 5 Human Functional pEC50 = 7.9 7.9 2 3
Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptorEffective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptor
ChEMBL 483 5 4 9 0.7 OC[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm981090+
CHEMBL66393 205984 None 5 Human Functional pEC50 = 7.9 7.9 2 3
Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptorEffective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptor
ChEMBL 483 5 4 9 0.7 OC[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm981090+
118732975 118580 None 0 Human Functional pEC50 = 7.9 7.9 -4 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 407 5 3 12 0.1 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CC5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
CHEMBL3414941 118580 None 0 Human Functional pEC50 = 7.9 7.9 -4 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 407 5 3 12 0.1 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CC5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
377 2758 None 42 Human Functional pEC50 = 7.9 7.9 -3 10
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.8b00047
425 2758 None 42 Human Functional pEC50 = 7.9 7.9 -3 10
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.8b00047
448222 2758 None 42 Human Functional pEC50 = 7.9 7.9 -3 10
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.8b00047
CHEMBL464859 2758 None 42 Human Functional pEC50 = 7.9 7.9 -3 10
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.8b00047
44232535 95668 None 0 Human Functional pEC50 = 7.9 7.9 - 1
Agonist activity at human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 538 8 5 9 1.7 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(Cl)c4)nc(C#CCCCC(=O)O)nc31)[C@H](O)[C@@H]2O 10.1016/j.bmcl.2008.04.001
CHEMBL257833 95668 None 0 Human Functional pEC50 = 7.9 7.9 - 1
Agonist activity at human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 538 8 5 9 1.7 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(Cl)c4)nc(C#CCCCC(=O)O)nc31)[C@H](O)[C@@H]2O 10.1016/j.bmcl.2008.04.001
137657926 159862 None 0 Human Functional pEC50 = 7.8 7.8 -1 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 421 6 3 12 0.3 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCC5CC5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
CHEMBL4105164 159862 None 0 Human Functional pEC50 = 7.8 7.8 -1 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 421 6 3 12 0.3 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCC5CC5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
377 2758 None 42 Human Functional pEC50 = 7.8 7.8 -3 10
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.2c01414
425 2758 None 42 Human Functional pEC50 = 7.8 7.8 -3 10
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.2c01414
448222 2758 None 42 Human Functional pEC50 = 7.8 7.8 -3 10
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.2c01414
CHEMBL464859 2758 None 42 Human Functional pEC50 = 7.8 7.8 -3 10
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.2c01414
137646828 158098 None 0 Human Functional pEC50 = 5.9 5.9 -25 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 856 16 6 13 6.2 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCCCCCNC(=O)c4ccc(-c5sc(N)c(C(=O)c6ccccc6)c5-c5cccc(C(F)(F)F)c5)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.8b00047
CHEMBL4085418 158098 None 0 Human Functional pEC50 = 5.9 5.9 -25 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 856 16 6 13 6.2 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCCCCCNC(=O)c4ccc(-c5sc(N)c(C(=O)c6ccccc6)c5-c5cccc(C(F)(F)F)c5)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.8b00047
168297905 192540 None 0 Human Functional pEC50 = 5.9 5.9 -660 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 516 8 4 10 1.8 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4ccccc4Cl)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
CHEMBL5208245 192540 None 0 Human Functional pEC50 = 5.9 5.9 -660 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 516 8 4 10 1.8 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4ccccc4Cl)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
168272014 190319 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 594 12 5 11 3.0 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OCCCC4CCCCC4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5174613 190319 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 594 12 5 11 3.0 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OCCCC4CCCCC4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
168283013 190984 None 0 Human Functional pEC50 = 5.8 5.8 -288 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 516 8 4 10 1.8 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4cccc(Cl)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
CHEMBL5184828 190984 None 0 Human Functional pEC50 = 5.8 5.8 -288 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 516 8 4 10 1.8 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4cccc(Cl)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
76318139 105742 None 0 Human Functional pEC50 = 7.8 7.8 - 1
Partial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminasePartial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminase
ChEMBL 355 5 3 7 1.7 CCCCC#Cc1nc(NCC)c2ncn([C@H]3[C@H](O)[C@H](O)[C@@H]4C[C@@H]43)c2n1 10.1021/jm4015313
CHEMBL3125713 105742 None 0 Human Functional pEC50 = 7.8 7.8 - 1
Partial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminasePartial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminase
ChEMBL 355 5 3 7 1.7 CCCCC#Cc1nc(NCC)c2ncn([C@H]3[C@H](O)[C@H](O)[C@@H]4C[C@@H]43)c2n1 10.1021/jm4015313
76329265 106116 None 0 Human Functional pEC50 = 7.8 7.8 2 4
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 377 4 5 10 -0.9 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(N)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
CHEMBL3133158 106116 None 0 Human Functional pEC50 = 7.8 7.8 2 4
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 377 4 5 10 -0.9 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(N)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
168289948 191731 None 2 Human Functional pEC50 = 7.8 7.8 4 2
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 315 4 1 5 3.6 Cn1nc(-c2ccccc2)c2cnnc(NCc3ccccc3)c21 10.1021/acsmedchemlett.2c00052
CHEMBL5195631 191731 None 2 Human Functional pEC50 = 7.8 7.8 4 2
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 1 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 315 4 1 5 3.6 Cn1nc(-c2ccccc2)c2cnnc(NCc3ccccc3)c21 10.1021/acsmedchemlett.2c00052
377 2758 None 42 Human Functional pEC50 = 7.8 7.8 -3 10
Irreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.6b01561
425 2758 None 42 Human Functional pEC50 = 7.8 7.8 -3 10
Irreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.6b01561
448222 2758 None 42 Human Functional pEC50 = 7.8 7.8 -3 10
Irreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.6b01561
CHEMBL464859 2758 None 42 Human Functional pEC50 = 7.8 7.8 -3 10
Irreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.6b01561
168294594 192448 None 0 Human Functional pEC50 = 5.8 5.8 -141 2
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 560 8 4 10 1.9 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4ccc(Br)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
CHEMBL5206687 192448 None 0 Human Functional pEC50 = 5.8 5.8 -141 2
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 560 8 4 10 1.9 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4ccc(Br)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
377 2758 None 42 Human Functional pEC50 = 6.8 6.8 -3 10
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.ejmech.2021.113983
425 2758 None 42 Human Functional pEC50 = 6.8 6.8 -3 10
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.ejmech.2021.113983
448222 2758 None 42 Human Functional pEC50 = 6.8 6.8 -3 10
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.ejmech.2021.113983
CHEMBL464859 2758 None 42 Human Functional pEC50 = 6.8 6.8 -3 10
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.ejmech.2021.113983
168297825 192392 None 0 Human Functional pEC50 = 6.8 6.8 -251 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 461 6 4 10 1.5 OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4cccc(Cl)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
CHEMBL5205907 192392 None 0 Human Functional pEC50 = 6.8 6.8 -251 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 461 6 4 10 1.5 OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4cccc(Cl)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
377 2758 None 42 Human Functional pEC50 = 6.8 6.8 -3 10
Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorStimulation of [35S]GTP-gamma-S, against human adenosine A3 receptor
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm9905965
425 2758 None 42 Human Functional pEC50 = 6.8 6.8 -3 10
Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorStimulation of [35S]GTP-gamma-S, against human adenosine A3 receptor
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm9905965
448222 2758 None 42 Human Functional pEC50 = 6.8 6.8 -3 10
Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorStimulation of [35S]GTP-gamma-S, against human adenosine A3 receptor
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm9905965
CHEMBL464859 2758 None 42 Human Functional pEC50 = 6.8 6.8 -3 10
Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorStimulation of [35S]GTP-gamma-S, against human adenosine A3 receptor
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm9905965
44359420 33220 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 531 13 7 12 -2.2 NC(=O)CCNC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C2N=CN1NCCc1ccc(CCC(=O)O)cc1 10.1021/jm020211+
CHEMBL141792 33220 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 531 13 7 12 -2.2 NC(=O)CCNC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C2N=CN1NCCc1ccc(CCC(=O)O)cc1 10.1021/jm020211+
155562467 175324 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Partial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assayPartial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assay
ChEMBL 497 6 4 9 2.5 COc1cc(CCNc2nc(C#Cc3ccccc3)nc3c2ncn3[C@H]2[C@H](O)[C@H](O)[C@@H]3C[C@@H]32)ccc1O 10.1021/acs.jmedchem.0c00235
CHEMBL4571380 175324 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Partial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assayPartial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assay
ChEMBL 497 6 4 9 2.5 COc1cc(CCNc2nc(C#Cc3ccccc3)nc3c2ncn3[C@H]2[C@H](O)[C@H](O)[C@@H]3C[C@@H]32)ccc1O 10.1021/acs.jmedchem.0c00235
164617060 185515 None 0 Human Functional pEC50 = 7.8 7.8 1621 2
Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as cAMP level measured after 35 mins by cAMP enzyme immunoassayAgonist activity at human adenosine A3 receptor transfected in CHO cells assessed as cAMP level measured after 35 mins by cAMP enzyme immunoassay
ChEMBL 440 9 4 9 1.0 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCCCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O 10.1016/j.ejmech.2021.113607
CHEMBL4861092 185515 None 0 Human Functional pEC50 = 7.8 7.8 1621 2
Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as cAMP level measured after 35 mins by cAMP enzyme immunoassayAgonist activity at human adenosine A3 receptor transfected in CHO cells assessed as cAMP level measured after 35 mins by cAMP enzyme immunoassay
ChEMBL 440 9 4 9 1.0 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCCCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O 10.1016/j.ejmech.2021.113607
168276883 190309 None 0 Human Functional pEC50 = 6.8 6.8 -309 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 502 7 4 10 1.6 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4cccc(Cl)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
CHEMBL5174429 190309 None 0 Human Functional pEC50 = 6.8 6.8 -309 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 502 7 4 10 1.6 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4cccc(Cl)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
372 58 None 56 Human Functional pEC50 = 5.8 5.8 -43 5
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 301 2 4 9 -1.3 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N 10.1021/jm020211+
8974 58 None 56 Human Functional pEC50 = 5.8 5.8 -43 5
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 301 2 4 9 -1.3 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N 10.1021/jm020211+
CHEMBL285819 58 None 56 Human Functional pEC50 = 5.8 5.8 -43 5
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 301 2 4 9 -1.3 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N 10.1021/jm020211+
168282699 191127 None 0 Human Functional pEC50 = 5.8 5.8 -1584 3
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 427 6 4 10 0.9 OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccccc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
CHEMBL5186757 191127 None 0 Human Functional pEC50 = 5.8 5.8 -1584 3
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 427 6 4 10 0.9 OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccccc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
162650156 180176 None 0 Rat Functional pEC50 = 5.8 5.8 - 1
Antagonist activity at rat A3AR expressed in CHO cells assessed as reduction in NECA-induced inhibition of forskolin-stimulated cAMP accumulation at 10 uM incubated for 2 hrs by fluorescence based assayAntagonist activity at rat A3AR expressed in CHO cells assessed as reduction in NECA-induced inhibition of forskolin-stimulated cAMP accumulation at 10 uM incubated for 2 hrs by fluorescence based assay
ChEMBL 524 5 1 7 6.7 O=C(Nc1nc(-c2ccccc2)c(-c2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)s1)c1ccco1 10.1016/j.ejmech.2019.111879
CHEMBL4747947 180176 None 0 Rat Functional pEC50 = 5.8 5.8 - 1
Antagonist activity at rat A3AR expressed in CHO cells assessed as reduction in NECA-induced inhibition of forskolin-stimulated cAMP accumulation at 10 uM incubated for 2 hrs by fluorescence based assayAntagonist activity at rat A3AR expressed in CHO cells assessed as reduction in NECA-induced inhibition of forskolin-stimulated cAMP accumulation at 10 uM incubated for 2 hrs by fluorescence based assay
ChEMBL 524 5 1 7 6.7 O=C(Nc1nc(-c2ccccc2)c(-c2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)s1)c1ccco1 10.1016/j.ejmech.2019.111879
377 2758 None 42 Human Functional pEC50 = 6.8 6.8 -3 10
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.ejmech.2021.113983
425 2758 None 42 Human Functional pEC50 = 6.8 6.8 -3 10
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.ejmech.2021.113983
448222 2758 None 42 Human Functional pEC50 = 6.8 6.8 -3 10
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.ejmech.2021.113983
CHEMBL464859 2758 None 42 Human Functional pEC50 = 6.8 6.8 -3 10
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.ejmech.2021.113983
76318140 105748 None 0 Human Functional pEC50 = 7.7 7.7 - 1
Partial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminasePartial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminase
ChEMBL 435 6 3 7 3.0 CCCCC#Cc1nc(NCc2cccc(F)c2)c2ncn([C@H]3[C@H](O)[C@H](O)[C@@H]4C[C@@H]43)c2n1 10.1021/jm4015313
CHEMBL3125719 105748 None 0 Human Functional pEC50 = 7.7 7.7 - 1
Partial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminasePartial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminase
ChEMBL 435 6 3 7 3.0 CCCCC#Cc1nc(NCc2cccc(F)c2)c2ncn([C@H]3[C@H](O)[C@H](O)[C@@H]4C[C@@H]43)c2n1 10.1021/jm4015313
11584486 140995 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Activity against human adenosine A3 receptor H272E mutant expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayActivity against human adenosine A3 receptor H272E mutant expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
ChEMBL 525 6 5 9 0.3 NC(=O)N[C@@H]1[C@@H](CO)O[C@@H](n2cnc3c(NCc4cccc(I)c4)ncnc32)[C@@H]1O 10.1021/jm050968b
CHEMBL382194 140995 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Activity against human adenosine A3 receptor H272E mutant expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayActivity against human adenosine A3 receptor H272E mutant expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
ChEMBL 525 6 5 9 0.3 NC(=O)N[C@@H]1[C@@H](CO)O[C@@H](n2cnc3c(NCc4cccc(I)c4)ncnc32)[C@@H]1O 10.1021/jm050968b
168285984 191851 None 0 Human Functional pEC50 = 6.7 6.7 -199 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 461 6 4 10 1.5 OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccccc4Cl)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
CHEMBL5197358 191851 None 0 Human Functional pEC50 = 6.7 6.7 -199 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 461 6 4 10 1.5 OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccccc4Cl)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
377 2758 None 42 Mouse Functional pEC50 = 6.7 6.7 -54 10
Partial agonist activity at recombinant mouse A3AR expressed in HEK293 cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 2 hrs in presence of A2BAR blocker PSB-603 by liquid scintillation counting analysisPartial agonist activity at recombinant mouse A3AR expressed in HEK293 cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 2 hrs in presence of A2BAR blocker PSB-603 by liquid scintillation counting analysis
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.0c00235
425 2758 None 42 Mouse Functional pEC50 = 6.7 6.7 -54 10
Partial agonist activity at recombinant mouse A3AR expressed in HEK293 cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 2 hrs in presence of A2BAR blocker PSB-603 by liquid scintillation counting analysisPartial agonist activity at recombinant mouse A3AR expressed in HEK293 cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 2 hrs in presence of A2BAR blocker PSB-603 by liquid scintillation counting analysis
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.0c00235
448222 2758 None 42 Mouse Functional pEC50 = 6.7 6.7 -54 10
Partial agonist activity at recombinant mouse A3AR expressed in HEK293 cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 2 hrs in presence of A2BAR blocker PSB-603 by liquid scintillation counting analysisPartial agonist activity at recombinant mouse A3AR expressed in HEK293 cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 2 hrs in presence of A2BAR blocker PSB-603 by liquid scintillation counting analysis
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.0c00235
CHEMBL464859 2758 None 42 Mouse Functional pEC50 = 6.7 6.7 -54 10
Partial agonist activity at recombinant mouse A3AR expressed in HEK293 cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 2 hrs in presence of A2BAR blocker PSB-603 by liquid scintillation counting analysisPartial agonist activity at recombinant mouse A3AR expressed in HEK293 cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 2 hrs in presence of A2BAR blocker PSB-603 by liquid scintillation counting analysis
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.0c00235
76314563 105743 None 0 Human Functional pEC50 = 7.7 7.7 - 1
Partial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminasePartial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminase
ChEMBL 367 5 3 7 1.9 CCCCC#Cc1nc(NC2CC2)c2ncn([C@H]3[C@H](O)[C@H](O)[C@@H]4C[C@@H]43)c2n1 10.1021/jm4015313
CHEMBL3125714 105743 None 0 Human Functional pEC50 = 7.7 7.7 - 1
Partial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminasePartial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminase
ChEMBL 367 5 3 7 1.9 CCCCC#Cc1nc(NC2CC2)c2ncn([C@H]3[C@H](O)[C@H](O)[C@@H]4C[C@@H]43)c2n1 10.1021/jm4015313
57523252 76728 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay
ChEMBL 652 5 4 8 5.4 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(Cl)c4)nc(C#Cc4ccc5ccc6cccc7ccc4c5c67)nc31)[C@H](O)[C@@H]2O 10.1021/acs.jmedchem.8b00435
CHEMBL2064661 76728 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay
ChEMBL 652 5 4 8 5.4 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(Cl)c4)nc(C#Cc4ccc5ccc6cccc7ccc4c5c67)nc31)[C@H](O)[C@@H]2O 10.1021/acs.jmedchem.8b00435
137647420 157793 None 0 Human Functional pEC50 = 8.7 8.7 2 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 501 6 3 12 1.2 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(Br)c5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
CHEMBL4081876 157793 None 0 Human Functional pEC50 = 8.7 8.7 2 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 501 6 3 12 1.2 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(Br)c5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
137638080 156927 None 0 Human Functional pEC50 = 8.7 8.7 3 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 457 6 3 12 1.1 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(Cl)c5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
CHEMBL4071338 156927 None 0 Human Functional pEC50 = 8.7 8.7 3 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 457 6 3 12 1.1 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(Cl)c5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
137648928 157497 None 0 Human Functional pEC50 = 8.6 8.6 1 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 549 6 3 12 1.0 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(I)c5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
CHEMBL4078479 157497 None 0 Human Functional pEC50 = 8.6 8.6 1 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 549 6 3 12 1.0 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(I)c5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
71764235 91303 None 0 Mouse Functional pEC50 = 8.6 8.6 - 1
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISAAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA
ChEMBL 608 6 5 10 1.8 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(Cl)c4)nc(C#Cc4cccc(S(=O)(=O)O)c4)nc31)[C@H](O)[C@@H]2O 10.1021/jm4007966
CHEMBL2401955 91303 None 0 Mouse Functional pEC50 = 8.6 8.6 - 1
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISAAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA
ChEMBL 608 6 5 10 1.8 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(Cl)c4)nc(C#Cc4cccc(S(=O)(=O)O)c4)nc31)[C@H](O)[C@@H]2O 10.1021/jm4007966
16109359 161872 None 0 Human Functional pEC50 = 8.6 8.6 1 4
Activity at human adenosine A3 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation in CHO cellsActivity at human adenosine A3 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation in CHO cells
ChEMBL 924 21 6 14 4.5 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCCCNC(=O)CCCCCNC(=O)COc4ccc(/C=C/C5=[N+]6C(=Cc7ccc(-c8cccs8)n7[B-]6(F)F)C=C5)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm061279i
CHEMBL414055 161872 None 0 Human Functional pEC50 = 8.6 8.6 1 4
Activity at human adenosine A3 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation in CHO cellsActivity at human adenosine A3 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation in CHO cells
ChEMBL 924 21 6 14 4.5 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCCCNC(=O)CCCCCNC(=O)COc4ccc(/C=C/C5=[N+]6C(=Cc7ccc(-c8cccs8)n7[B-]6(F)F)C=C5)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm061279i
16109359 161872 None 0 Human Functional pEC50 = 8.6 8.6 1 4
Agonist activity at human A3 adenosine receptor expressed in Flp-In-CHO cells assessed as stimulation of cAMP accumulation by competitive binding assayAgonist activity at human A3 adenosine receptor expressed in Flp-In-CHO cells assessed as stimulation of cAMP accumulation by competitive binding assay
ChEMBL 924 21 6 14 4.5 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCCCNC(=O)CCCCCNC(=O)COc4ccc(/C=C/C5=[N+]6C(=Cc7ccc(-c8cccs8)n7[B-]6(F)F)C=C5)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.0c02067
CHEMBL414055 161872 None 0 Human Functional pEC50 = 8.6 8.6 1 4
Agonist activity at human A3 adenosine receptor expressed in Flp-In-CHO cells assessed as stimulation of cAMP accumulation by competitive binding assayAgonist activity at human A3 adenosine receptor expressed in Flp-In-CHO cells assessed as stimulation of cAMP accumulation by competitive binding assay
ChEMBL 924 21 6 14 4.5 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCCCNC(=O)CCCCCNC(=O)COc4ccc(/C=C/C5=[N+]6C(=Cc7ccc(-c8cccs8)n7[B-]6(F)F)C=C5)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.0c02067
132938348 158306 None 0 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as decrease in forskolin induced cAMP formation preincubated for 10 mins followed by forskolin challenge measured after 15 mins by AlphaScreen assayAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as decrease in forskolin induced cAMP formation preincubated for 10 mins followed by forskolin challenge measured after 15 mins by AlphaScreen assay
ChEMBL 574 5 4 8 0.5 CNC(=O)[C@H]1[Se][C@@H](n2cnc3c(NCc4cccc(I)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.7b00241
CHEMBL4088081 158306 None 0 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as decrease in forskolin induced cAMP formation preincubated for 10 mins followed by forskolin challenge measured after 15 mins by AlphaScreen assayAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as decrease in forskolin induced cAMP formation preincubated for 10 mins followed by forskolin challenge measured after 15 mins by AlphaScreen assay
ChEMBL 574 5 4 8 0.5 CNC(=O)[C@H]1[Se][C@@H](n2cnc3c(NCc4cccc(I)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.7b00241
45482610 200483 None 0 Human Functional pEC50 = 8.6 8.6 2 2
Agonistic effect at human adenosine A3 receptor in CHO cellsAgonistic effect at human adenosine A3 receptor in CHO cells
ChEMBL 406 4 4 8 0.9 CNC(=O)[C@]12C[C@@H]1[C@@H](n1cnc3c(NC4CCCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O 10.1021/jm050726b
CHEMBL573937 200483 None 0 Human Functional pEC50 = 8.6 8.6 2 2
Agonistic effect at human adenosine A3 receptor in CHO cellsAgonistic effect at human adenosine A3 receptor in CHO cells
ChEMBL 406 4 4 8 0.9 CNC(=O)[C@]12C[C@@H]1[C@@H](n1cnc3c(NC4CCCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O 10.1021/jm050726b
3035850 951 None 50 Human Functional pEC50 = 8.6 8.6 -14 2
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/jm020211+
3035850.0 951 None 50 Human Functional pEC50 = 8.6 8.6 -14 2
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/jm020211+
457 951 None 50 Human Functional pEC50 = 8.6 8.6 -14 2
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/jm020211+
CHEMBL431733 951 None 50 Human Functional pEC50 = 8.6 8.6 -14 2
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/jm020211+
DB12885 951 None 50 Human Functional pEC50 = 8.6 8.6 -14 2
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/jm020211+
127047826 140093 None 0 Mouse Functional pEC50 = 7.7 7.7 - 1
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forsolkin addition measured after 15 mins by immunoassayAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forsolkin addition measured after 15 mins by immunoassay
ChEMBL 403 2 3 7 0.6 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(C)nc(C#Cc4ccccc4)nc31)[C@H](O)[C@@H]2O 10.1021/acs.jmedchem.5b01998
CHEMBL3800048 140093 None 0 Mouse Functional pEC50 = 7.7 7.7 - 1
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forsolkin addition measured after 15 mins by immunoassayAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forsolkin addition measured after 15 mins by immunoassay
ChEMBL 403 2 3 7 0.6 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(C)nc(C#Cc4ccccc4)nc31)[C@H](O)[C@@H]2O 10.1021/acs.jmedchem.5b01998
415 3651 None 7 Human Functional pEC50 = 6.7 6.7 -1 2
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 385 6 4 9 0.5 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H](Cc1ccccc1)C 10.1021/jm020211+
5312112 3651 None 7 Human Functional pEC50 = 6.7 6.7 -1 2
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 385 6 4 9 0.5 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H](Cc1ccccc1)C 10.1021/jm020211+
CHEMBL420705 3651 None 7 Human Functional pEC50 = 6.7 6.7 -1 2
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 385 6 4 9 0.5 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H](Cc1ccccc1)C 10.1021/jm020211+
168270868 190040 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 578 7 5 11 1.8 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(O)c(OC)c4)nc(C#Cc4ccc(F)s4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5170037 190040 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 578 7 5 11 1.8 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(O)c(OC)c4)nc(C#Cc4ccc(F)s4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
168280775 191266 None 0 Human Functional pEC50 = 6.6 6.6 -15 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 524 7 4 10 2.3 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccc(C(C)(C)C)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
CHEMBL5188601 191266 None 0 Human Functional pEC50 = 6.6 6.6 -15 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 524 7 4 10 2.3 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccc(C(C)(C)C)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
168270868 190040 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 578 7 5 11 1.8 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(O)c(OC)c4)nc(C#Cc4ccc(F)s4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5170037 190040 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 578 7 5 11 1.8 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(O)c(OC)c4)nc(C#Cc4ccc(F)s4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
155537599 172427 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Partial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assayPartial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assay
ChEMBL 491 5 3 8 3.5 O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NCCc3ccccc3)nc(C#Cc3ccc(Cl)s3)nc21 10.1021/acs.jmedchem.0c00235
CHEMBL4475372 172427 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Partial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assayPartial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assay
ChEMBL 491 5 3 8 3.5 O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NCCc3ccccc3)nc(C#Cc3ccc(Cl)s3)nc21 10.1021/acs.jmedchem.0c00235
380 1287 None 37 Human Functional pEC50 = 6.6 6.6 -724 5
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 335 4 4 9 -0.2 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1 10.1021/jm020211+
657378 1287 None 37 Human Functional pEC50 = 6.6 6.6 -724 5
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 335 4 4 9 -0.2 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1 10.1021/jm020211+
CHEMBL68738 1287 None 37 Human Functional pEC50 = 6.6 6.6 -724 5
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 335 4 4 9 -0.2 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1 10.1021/jm020211+
137657841 159664 None 0 Human Functional pEC50 = 7.6 7.6 1 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 475 6 3 12 1.2 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5ccc(Cl)cc5F)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
CHEMBL4102750 159664 None 0 Human Functional pEC50 = 7.6 7.6 1 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 475 6 3 12 1.2 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5ccc(Cl)cc5F)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
168278159 190469 None 0 Human Functional pEC50 = 5.6 5.6 -812 4
Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assay
ChEMBL 839 15 5 15 6.6 Nc1sc(-c2ccc(-c3cn(CCCCCCNc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)nn3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.2c00320
CHEMBL5177040 190469 None 0 Human Functional pEC50 = 5.6 5.6 -812 4
Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assay
ChEMBL 839 15 5 15 6.6 Nc1sc(-c2ccc(-c3cn(CCCCCCNc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)nn3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.2c00320
76332918 106110 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 433 7 4 10 0.4 CCN(CC)c1nc(NC2CCCC2)c2ncn([C@@H]3O[C@H](C(=O)NC)[C@@H](O)[C@H]3O)c2n1 10.1039/C3MD00364G
CHEMBL3133152 106110 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 433 7 4 10 0.4 CCN(CC)c1nc(NC2CCCC2)c2ncn([C@@H]3O[C@H](C(=O)NC)[C@@H](O)[C@H]3O)c2n1 10.1039/C3MD00364G
10450691 99512 None 0 Human Functional pEC50 = 4.6 4.6 - 1
Agonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, by activation of human A3AR receptorAgonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, by activation of human A3AR receptor
ChEMBL 352 3 4 8 -0.5 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(Cl)nc31)[C@H](O)[C@@H]2O 10.1016/s0960-894x(01)00213-x
CHEMBL283057 99512 None 0 Human Functional pEC50 = 4.6 4.6 - 1
Agonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, by activation of human A3AR receptorAgonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, by activation of human A3AR receptor
ChEMBL 352 3 4 8 -0.5 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(Cl)nc31)[C@H](O)[C@@H]2O 10.1016/s0960-894x(01)00213-x
377 2758 None 42 Human Functional pEC50 = 7.6 7.6 -3 10
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm020211+
425 2758 None 42 Human Functional pEC50 = 7.6 7.6 -3 10
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm020211+
448222 2758 None 42 Human Functional pEC50 = 7.6 7.6 -3 10
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm020211+
CHEMBL464859 2758 None 42 Human Functional pEC50 = 7.6 7.6 -3 10
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm020211+
8975 100453 None 49 Human Functional pEC50 = 5.6 5.6 - 1
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 285 2 4 9 -1.8 Nc1nc(F)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O 10.1021/jm020211+
CHEMBL290077 100453 None 49 Human Functional pEC50 = 5.6 5.6 - 1
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 285 2 4 9 -1.8 Nc1nc(F)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O 10.1021/jm020211+
414 3382 None 22 Human Functional pEC50 = 7.6 7.6 -3 5
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 385 6 4 9 0.5 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C 10.1021/jm020211+
93205 3382 None 22 Human Functional pEC50 = 7.6 7.6 -3 5
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 385 6 4 9 0.5 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C 10.1021/jm020211+
CHEMBL139000 3382 None 22 Human Functional pEC50 = 7.6 7.6 -3 5
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 385 6 4 9 0.5 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C 10.1021/jm020211+
11756182 79256 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptorEffective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptor
ChEMBL 513 6 3 9 2.0 CSC[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm981090+
CHEMBL2113427 79256 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptorEffective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptor
ChEMBL 513 6 3 9 2.0 CSC[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm981090+
76332686 105744 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Partial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminasePartial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminase
ChEMBL 395 5 3 7 2.6 CCCCC#Cc1nc(NC2CCCC2)c2ncn([C@H]3[C@H](O)[C@H](O)[C@@H]4C[C@@H]43)c2n1 10.1021/jm4015313
CHEMBL3125715 105744 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Partial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminasePartial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminase
ChEMBL 395 5 3 7 2.6 CCCCC#Cc1nc(NC2CCCC2)c2ncn([C@H]3[C@H](O)[C@H](O)[C@@H]4C[C@@H]43)c2n1 10.1021/jm4015313
168270204 190172 None 0 Human Functional pEC50 = 5.6 5.6 -19498 2
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 560 8 4 10 1.9 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4cccc(Br)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
CHEMBL5172389 190172 None 0 Human Functional pEC50 = 5.6 5.6 -19498 2
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 560 8 4 10 1.9 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4cccc(Br)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
168283120 191170 None 0 Human Functional pEC50 = 5.6 5.6 -20892 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 498 8 4 11 1.0 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4cccc(OC)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
CHEMBL5187330 191170 None 0 Human Functional pEC50 = 5.6 5.6 -20892 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 498 8 4 11 1.0 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4cccc(OC)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
144852560 171039 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Antagonist activity at human A3AR expressed in CHO cells assessed as suppression of NECA-induced reduction in cAMP accumulationAntagonist activity at human A3AR expressed in CHO cells assessed as suppression of NECA-induced reduction in cAMP accumulation
ChEMBL 343 2 2 5 3.8 Clc1ccc(C#Cc2nc(NC3CCCC3)c3nc[nH]c3n2)s1 10.1039/C8MD00317C
CHEMBL4455344 171039 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Antagonist activity at human A3AR expressed in CHO cells assessed as suppression of NECA-induced reduction in cAMP accumulationAntagonist activity at human A3AR expressed in CHO cells assessed as suppression of NECA-induced reduction in cAMP accumulation
ChEMBL 343 2 2 5 3.8 Clc1ccc(C#Cc2nc(NC3CCCC3)c3nc[nH]c3n2)s1 10.1039/C8MD00317C
137639588 156976 None 0 Human Functional pEC50 = 6.6 6.6 1 3
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 815 15 6 13 6.1 Nc1sc(-c2ccccc2C(=O)NCCCCCCNc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.8b00047
CHEMBL4072009 156976 None 0 Human Functional pEC50 = 6.6 6.6 1 3
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 815 15 6 13 6.1 Nc1sc(-c2ccccc2C(=O)NCCCCCCNc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.8b00047
137646655 157718 None 0 Human Functional pEC50 = 6.6 6.6 -4 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 711 13 6 12 4.8 Nc1cc(-c2cccc(C(F)(F)F)c2)c(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)s1 10.1021/acs.jmedchem.8b00047
CHEMBL4081224 157718 None 0 Human Functional pEC50 = 6.6 6.6 -4 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 711 13 6 12 4.8 Nc1cc(-c2cccc(C(F)(F)F)c2)c(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)s1 10.1021/acs.jmedchem.8b00047
2844 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human adenosine A3 receptor expressed in CHO cellsAgonist activity at human adenosine A3 receptor expressed in CHO cells
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.bmcl.2011.02.053
60961 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human adenosine A3 receptor expressed in CHO cellsAgonist activity at human adenosine A3 receptor expressed in CHO cells
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.bmcl.2011.02.053
60961.0 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human adenosine A3 receptor expressed in CHO cellsAgonist activity at human adenosine A3 receptor expressed in CHO cells
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.bmcl.2011.02.053
90 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human adenosine A3 receptor expressed in CHO cellsAgonist activity at human adenosine A3 receptor expressed in CHO cells
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.bmcl.2011.02.053
CHEMBL477 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human adenosine A3 receptor expressed in CHO cellsAgonist activity at human adenosine A3 receptor expressed in CHO cells
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.bmcl.2011.02.053
DB00640 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human adenosine A3 receptor expressed in CHO cellsAgonist activity at human adenosine A3 receptor expressed in CHO cells
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.bmcl.2011.02.053
2844 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as increase of intracellular calcium levelAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as increase of intracellular calcium level
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.bmcl.2010.05.056
60961 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as increase of intracellular calcium levelAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as increase of intracellular calcium level
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.bmcl.2010.05.056
60961.0 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as increase of intracellular calcium levelAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as increase of intracellular calcium level
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.bmcl.2010.05.056
90 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as increase of intracellular calcium levelAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as increase of intracellular calcium level
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.bmcl.2010.05.056
CHEMBL477 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as increase of intracellular calcium levelAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as increase of intracellular calcium level
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.bmcl.2010.05.056
DB00640 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as increase of intracellular calcium levelAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as increase of intracellular calcium level
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.bmcl.2010.05.056
2844 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosineAgonist activity at human adenosine A3 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.5b00828
60961 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosineAgonist activity at human adenosine A3 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.5b00828
60961.0 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosineAgonist activity at human adenosine A3 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.5b00828
90 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosineAgonist activity at human adenosine A3 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.5b00828
CHEMBL477 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosineAgonist activity at human adenosine A3 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.5b00828
DB00640 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosineAgonist activity at human adenosine A3 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.5b00828
2844 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human recombinant adenosine A3 receptor by cAMP assayAgonist activity at human recombinant adenosine A3 receptor by cAMP assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm4011669
60961 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human recombinant adenosine A3 receptor by cAMP assayAgonist activity at human recombinant adenosine A3 receptor by cAMP assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm4011669
60961.0 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human recombinant adenosine A3 receptor by cAMP assayAgonist activity at human recombinant adenosine A3 receptor by cAMP assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm4011669
90 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human recombinant adenosine A3 receptor by cAMP assayAgonist activity at human recombinant adenosine A3 receptor by cAMP assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm4011669
CHEMBL477 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human recombinant adenosine A3 receptor by cAMP assayAgonist activity at human recombinant adenosine A3 receptor by cAMP assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm4011669
DB00640 283 None 61 Human Functional pEC50 = 6.5 6.5 -1 5
Agonist activity at human recombinant adenosine A3 receptor by cAMP assayAgonist activity at human recombinant adenosine A3 receptor by cAMP assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm4011669
377 2758 None 42 Human Functional pEC50 = 8.5 8.5 -3 10
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1039/C3MD00364G
425 2758 None 42 Human Functional pEC50 = 8.5 8.5 -3 10
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1039/C3MD00364G
448222 2758 None 42 Human Functional pEC50 = 8.5 8.5 -3 10
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1039/C3MD00364G
CHEMBL464859 2758 None 42 Human Functional pEC50 = 8.5 8.5 -3 10
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1039/C3MD00364G
44354130 23531 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 554 5 4 8 1.7 CNC(=O)C12CC1C(n1cnc3c(NCc4cccc(I)c4)nc(Cl)nc31)C(O)C2O 10.1021/jm020211+
CHEMBL133387 23531 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 554 5 4 8 1.7 CNC(=O)C12CC1C(n1cnc3c(NCc4cccc(I)c4)nc(Cl)nc31)C(O)C2O 10.1021/jm020211+
CHEMBL5078671 217065 None 0 Human Functional pEC50 = 8.5 8.5 -1 2
Agonist activity at A3 adenosine receptor (unknown origin)Agonist activity at A3 adenosine receptor (unknown origin)
ChEMBL None None None CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCCCNC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](C)NC(=O)CCCCCNC(=O)COc4ccc(/C=C/C5=[N+]6C(=Cc7ccc(-c8cccs8)n7[B-]6(F)F)C=C5)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.0c02067
71764237 91307 None 0 Mouse Functional pEC50 = 8.5 8.5 - 1
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISAAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA
ChEMBL 508 6 4 8 1.9 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccccc4)nc(C#Cc4ccccc4)nc31)[C@H](O)[C@@H]2O 10.1021/jm4007966
CHEMBL2402024 91307 None 0 Mouse Functional pEC50 = 8.5 8.5 - 1
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISAAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA
ChEMBL 508 6 4 8 1.9 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccccc4)nc(C#Cc4ccccc4)nc31)[C@H](O)[C@@H]2O 10.1021/jm4007966
9828356 10532 None 13 Human Functional pEC50 = 8.5 8.5 - 1
Inhibition of isoproterenol-stimulated cAMP accumulation in HEK 293 cells expressing human Adenosine A3 receptorInhibition of isoproterenol-stimulated cAMP accumulation in HEK 293 cells expressing human Adenosine A3 receptor
ChEMBL 528 8 4 12 1.3 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cc(Cl)ccc4OCc4cc(C)no4)ncnc32)[C@H](O)[C@@H]1N 10.1021/jm0255724
CHEMBL116878 10532 None 13 Human Functional pEC50 = 8.5 8.5 - 1
Inhibition of isoproterenol-stimulated cAMP accumulation in HEK 293 cells expressing human Adenosine A3 receptorInhibition of isoproterenol-stimulated cAMP accumulation in HEK 293 cells expressing human Adenosine A3 receptor
ChEMBL 528 8 4 12 1.3 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cc(Cl)ccc4OCc4cc(C)no4)ncnc32)[C@H](O)[C@@H]1N 10.1021/jm0255724
137642036 158244 None 0 Human Functional pEC50 = 8.5 8.5 2 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 387 6 3 12 -0.4 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCC5CC5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
CHEMBL4087306 158244 None 0 Human Functional pEC50 = 8.5 8.5 2 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 387 6 3 12 -0.4 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCC5CC5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
123683 3121 None 46 Human Functional pEC50 = 8.4 8.4 67 5
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/jm020211+
422 3121 None 46 Human Functional pEC50 = 8.4 8.4 67 5
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/jm020211+
CHEMBL119709 3121 None 46 Human Functional pEC50 = 8.4 8.4 67 5
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/jm020211+
DB05511 3121 None 46 Human Functional pEC50 = 8.4 8.4 67 5
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/jm020211+
23643659 92362 None 0 Human Functional pEC50 = 8.4 8.4 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation
ChEMBL 454 5 1 4 6.3 O=C(Nc1nc2ccccc2c2cn(-c3ccccc3)nc12)C(c1ccccc1)c1ccccc1 10.1021/jm070123v
CHEMBL242849 92362 None 0 Human Functional pEC50 = 8.4 8.4 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation
ChEMBL 454 5 1 4 6.3 O=C(Nc1nc2ccccc2c2cn(-c3ccccc3)nc12)C(c1ccccc1)c1ccccc1 10.1021/jm070123v
76329263 106103 None 0 Human Functional pEC50 = 8.4 8.4 19 4
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 413 6 5 10 -0.6 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCc4ccccc4)nc(N)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
CHEMBL3133079 106103 None 0 Human Functional pEC50 = 8.4 8.4 19 4
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 413 6 5 10 -0.6 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCc4ccccc4)nc(N)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
168293442 192244 None 0 Human Functional pEC50 = 5.5 5.5 -12589 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 546 7 4 10 1.8 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4cccc(Br)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
CHEMBL5203632 192244 None 0 Human Functional pEC50 = 5.5 5.5 -12589 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 546 7 4 10 1.8 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4cccc(Br)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
44563977 189808 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP release by TR-FRET assayAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP release by TR-FRET assay
ChEMBL 574 6 4 10 1.7 CNC(=O)OC[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)nc(Cl)nc32)[C@H](O)[C@@H]1O 10.1021/jm8014052
CHEMBL515442 189808 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP release by TR-FRET assayAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP release by TR-FRET assay
ChEMBL 574 6 4 10 1.7 CNC(=O)OC[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)nc(Cl)nc32)[C@H](O)[C@@H]1O 10.1021/jm8014052
168274237 190578 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 524 10 5 11 1.0 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OCC4CC4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5178814 190578 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 524 10 5 11 1.0 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OCC4CC4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
137651747 157573 None 0 Human Functional pEC50 = 7.5 7.5 -1 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 475 6 3 12 1.2 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(F)c5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
CHEMBL4079433 157573 None 0 Human Functional pEC50 = 7.5 7.5 -1 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 475 6 3 12 1.2 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(F)c5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
76329266 106118 None 0 Human Functional pEC50 = 7.5 7.5 3 4
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 399 5 5 10 -0.6 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4ccccc4)nc(N)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
CHEMBL3133160 106118 None 0 Human Functional pEC50 = 7.5 7.5 3 4
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 399 5 5 10 -0.6 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4ccccc4)nc(N)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
56627882 118576 None 0 Human Functional pEC50 = 7.5 7.5 -8 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 367 3 3 12 -0.9 CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
CHEMBL3414937 118576 None 0 Human Functional pEC50 = 7.5 7.5 -8 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 367 3 3 12 -0.9 CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
57523253 76702 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay
ChEMBL 652 5 4 8 5.4 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(Cl)c4)nc(C#Cc4cc5cccc6ccc7cccc4c7c65)nc31)[C@H](O)[C@@H]2O 10.1021/acs.jmedchem.8b00435
CHEMBL2064634 76702 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay
ChEMBL 652 5 4 8 5.4 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(Cl)c4)nc(C#Cc4cc5cccc6ccc7cccc4c7c65)nc31)[C@H](O)[C@@H]2O 10.1021/acs.jmedchem.8b00435
118732980 118585 None 0 Human Functional pEC50 = 7.5 7.5 -4 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 461 5 3 12 1.4 CCn1nnc([C@H]2O[C@@H](n3cnc4c(Nc5ccc(Cl)cc5F)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
CHEMBL3414946 118585 None 0 Human Functional pEC50 = 7.5 7.5 -4 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 461 5 3 12 1.4 CCn1nnc([C@H]2O[C@@H](n3cnc4c(Nc5ccc(Cl)cc5F)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
137652475 157237 None 0 Human Functional pEC50 = 6.5 6.5 -4 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 829 16 6 13 6.5 Nc1sc(-c2ccc(C(=O)NCCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.8b00047
CHEMBL4075186 157237 None 0 Human Functional pEC50 = 6.5 6.5 -4 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 829 16 6 13 6.5 Nc1sc(-c2ccc(C(=O)NCCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.8b00047
137641858 158399 None 0 Human Functional pEC50 = 6.5 6.5 -3 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 696 13 5 11 5.3 O=C(NCCCCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1ccc(-c2sccc2-c2cccc(C(F)(F)F)c2)cc1 10.1021/acs.jmedchem.8b00047
CHEMBL4089092 158399 None 0 Human Functional pEC50 = 6.5 6.5 -3 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 696 13 5 11 5.3 O=C(NCCCCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1ccc(-c2sccc2-c2cccc(C(F)(F)F)c2)cc1 10.1021/acs.jmedchem.8b00047
377 2758 None 42 Human Functional pEC50 = 6.5 6.5 -3 10
Agonist activity at human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.bmcl.2008.04.001
425 2758 None 42 Human Functional pEC50 = 6.5 6.5 -3 10
Agonist activity at human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.bmcl.2008.04.001
448222 2758 None 42 Human Functional pEC50 = 6.5 6.5 -3 10
Agonist activity at human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.bmcl.2008.04.001
CHEMBL464859 2758 None 42 Human Functional pEC50 = 6.5 6.5 -3 10
Agonist activity at human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1016/j.bmcl.2008.04.001
162645916 179602 None 0 Human Functional pEC50 = 6.5 6.5 -4 4
Irreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay
ChEMBL 414 6 4 11 0.8 OC[C@H]1O[C@@H](n2cnc3c(Nc4ccc(CN=C=S)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.6b01561
CHEMBL4741079 179602 None 0 Human Functional pEC50 = 6.5 6.5 -4 4
Irreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay
ChEMBL 414 6 4 11 0.8 OC[C@H]1O[C@@H](n2cnc3c(Nc4ccc(CN=C=S)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.6b01561
168288096 191812 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 580 6 5 11 2.3 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4ccc(O)c(OC)c4)nc(C#Cc4ccc(Cl)s4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5196916 191812 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 580 6 5 11 2.3 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4ccc(O)c(OC)c4)nc(C#Cc4ccc(Cl)s4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
168288096 191812 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 580 6 5 11 2.3 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4ccc(O)c(OC)c4)nc(C#Cc4ccc(Cl)s4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5196916 191812 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 580 6 5 11 2.3 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4ccc(O)c(OC)c4)nc(C#Cc4ccc(Cl)s4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
42626221 179519 None 12 Human Functional pEC50 = 7.4 7.4 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated cAMP accumulation
ChEMBL 412 4 1 8 2.7 COc1ccc(-n2nc3c(NC(=O)c4ccccc4)nc4ncccc4n3c2=O)cc1 10.1021/jm8014876
CHEMBL474016 179519 None 12 Human Functional pEC50 = 7.4 7.4 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated cAMP accumulation
ChEMBL 412 4 1 8 2.7 COc1ccc(-n2nc3c(NC(=O)c4ccccc4)nc4ncccc4n3c2=O)cc1 10.1021/jm8014876
393595 2637 None 36 Human Functional pEC50 = 7.4 7.4 16 3
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 10 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 10 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 403 4 1 6 4.4 O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1 10.1021/acsmedchemlett.2c00052
448 2637 None 36 Human Functional pEC50 = 7.4 7.4 16 3
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 10 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 10 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 403 4 1 6 4.4 O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1 10.1021/acsmedchemlett.2c00052
CHEMBL88147 2637 None 36 Human Functional pEC50 = 7.4 7.4 16 3
Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 10 uM incubated with NECA for 30 mins by LANCE cAMP detection assayAntagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measuring NECA-mediated cAMP stimulation at 10 uM incubated with NECA for 30 mins by LANCE cAMP detection assay
ChEMBL 403 4 1 6 4.4 O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1 10.1021/acsmedchemlett.2c00052
118732981 118586 None 0 Human Functional pEC50 = 7.4 7.4 -1 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 495 5 3 12 2.0 CCn1nnc([C@H]2O[C@@H](n3cnc4c(Nc5ccc(Cl)cc5F)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
CHEMBL3414947 118586 None 0 Human Functional pEC50 = 7.4 7.4 -1 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 495 5 3 12 2.0 CCn1nnc([C@H]2O[C@@H](n3cnc4c(Nc5ccc(Cl)cc5F)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
168274237 190578 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 524 10 5 11 1.0 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OCC4CC4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5178814 190578 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 524 10 5 11 1.0 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OCC4CC4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
98567 191890 None 12 Human Functional pEC50 = 7.4 7.4 2 3
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of cAMP productionAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of cAMP production
ChEMBL 294 2 4 9 -2.2 CNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O 10.1021/acsmedchemlett.5b00150
CHEMBL519809 191890 None 12 Human Functional pEC50 = 7.4 7.4 2 3
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of cAMP productionAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of cAMP production
ChEMBL 294 2 4 9 -2.2 CNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O 10.1021/acsmedchemlett.5b00150
168277923 190788 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 484 8 5 11 0.2 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OC)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5181821 190788 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 484 8 5 11 0.2 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OC)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
92208 142440 None 42 Human Functional pEC50 = 6.4 6.4 -3 2
Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptorEffective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptor
ChEMBL 357 5 4 9 0.1 OC[C@H]1O[C@@H](n2cnc3c(NCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm981090+
CHEMBL388757 142440 None 42 Human Functional pEC50 = 6.4 6.4 -3 2
Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptorEffective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptor
ChEMBL 357 5 4 9 0.1 OC[C@H]1O[C@@H](n2cnc3c(NCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm981090+
118732975 118580 None 0 Human Functional pEC50 = 7.4 7.4 -4 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 407 5 3 12 0.1 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CC5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
CHEMBL3414941 118580 None 0 Human Functional pEC50 = 7.4 7.4 -4 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 407 5 3 12 0.1 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CC5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
168281601 191380 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 594 7 5 11 2.3 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(O)c(OC)c4)nc(C#Cc4ccc(Cl)s4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5190575 191380 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 594 7 5 11 2.3 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(O)c(OC)c4)nc(C#Cc4ccc(Cl)s4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
76329264 106109 None 0 Human Functional pEC50 = 7.4 7.4 12 3
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 405 6 5 10 -0.0 CCNc1nc(NC2CCCC2)c2ncn([C@@H]3O[C@H](C(=O)NC)[C@@H](O)[C@H]3O)c2n1 10.1039/C3MD00364G
CHEMBL3133151 106109 None 0 Human Functional pEC50 = 7.4 7.4 12 3
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 405 6 5 10 -0.0 CCNc1nc(NC2CCCC2)c2ncn([C@@H]3O[C@H](C(=O)NC)[C@@H](O)[C@H]3O)c2n1 10.1039/C3MD00364G
76311197 106114 None 0 Human Functional pEC50 = 7.4 7.4 19 3
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 365 6 5 10 -1.0 CCCCNc1nc(N)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O 10.1039/C3MD00364G
CHEMBL3133156 106114 None 0 Human Functional pEC50 = 7.4 7.4 19 3
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 365 6 5 10 -1.0 CCCCNc1nc(N)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O 10.1039/C3MD00364G
3035850 951 None 50 Human Functional pEC50 = 8.4 8.4 -14 2
Partial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assayPartial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assay
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/acs.jmedchem.0c00235
3035850.0 951 None 50 Human Functional pEC50 = 8.4 8.4 -14 2
Partial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assayPartial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assay
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/acs.jmedchem.0c00235
457 951 None 50 Human Functional pEC50 = 8.4 8.4 -14 2
Partial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assayPartial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assay
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/acs.jmedchem.0c00235
CHEMBL431733 951 None 50 Human Functional pEC50 = 8.4 8.4 -14 2
Partial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assayPartial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assay
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/acs.jmedchem.0c00235
DB12885 951 None 50 Human Functional pEC50 = 8.4 8.4 -14 2
Partial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assayPartial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assay
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/acs.jmedchem.0c00235
44579716 187092 None 0 Human Functional pEC50 = 8.4 8.4 - 1
Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated 45 mins before forskolin challenge measured after 15 mins by radioimmunoassay relative to NECAAgonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated 45 mins before forskolin challenge measured after 15 mins by radioimmunoassay relative to NECA
ChEMBL 449 4 3 7 2.8 O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NCc3cccc(Br)c3)nc(Cl)nc21 10.1021/jm900426g
CHEMBL490606 187092 None 0 Human Functional pEC50 = 8.4 8.4 - 1
Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated 45 mins before forskolin challenge measured after 15 mins by radioimmunoassay relative to NECAAgonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated 45 mins before forskolin challenge measured after 15 mins by radioimmunoassay relative to NECA
ChEMBL 449 4 3 7 2.8 O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NCc3cccc(Br)c3)nc(Cl)nc21 10.1021/jm900426g
377 2758 None 42 Human Functional pEC50 = 8.3 8.3 -3 10
Activity at human adenosine A3 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation in CHO cellsActivity at human adenosine A3 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation in CHO cells
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm061279i
425 2758 None 42 Human Functional pEC50 = 8.3 8.3 -3 10
Activity at human adenosine A3 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation in CHO cellsActivity at human adenosine A3 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation in CHO cells
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm061279i
448222 2758 None 42 Human Functional pEC50 = 8.3 8.3 -3 10
Activity at human adenosine A3 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation in CHO cellsActivity at human adenosine A3 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation in CHO cells
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm061279i
CHEMBL464859 2758 None 42 Human Functional pEC50 = 8.3 8.3 -3 10
Activity at human adenosine A3 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation in CHO cellsActivity at human adenosine A3 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation in CHO cells
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm061279i
136048802 140103 None 0 Mouse Functional pEC50 = 8.3 8.3 - 1
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forsolkin addition measured after 15 mins by immunoassayAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forsolkin addition measured after 15 mins by immunoassay
ChEMBL 507 4 4 8 2.3 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(/C=C(\O)c4ccccc4)nc(C#Cc4ccccc4)nc31)[C@H](O)[C@@H]2O 10.1021/acs.jmedchem.5b01998
CHEMBL3800106 140103 None 0 Mouse Functional pEC50 = 8.3 8.3 - 1
Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forsolkin addition measured after 15 mins by immunoassayAgonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forsolkin addition measured after 15 mins by immunoassay
ChEMBL 507 4 4 8 2.3 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(/C=C(\O)c4ccccc4)nc(C#Cc4ccccc4)nc31)[C@H](O)[C@@H]2O 10.1021/acs.jmedchem.5b01998
137649841 157522 None 0 Human Functional pEC50 = 6.4 6.4 -3 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 656 14 5 12 3.8 O=C(NCCCCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1cccc(-c2cc(C(=O)c3ccccc3)cs2)c1 10.1021/acs.jmedchem.8b00047
CHEMBL4078771 157522 None 0 Human Functional pEC50 = 6.4 6.4 -3 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 656 14 5 12 3.8 O=C(NCCCCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1cccc(-c2cc(C(=O)c3ccccc3)cs2)c1 10.1021/acs.jmedchem.8b00047
168269860 190085 None 0 Human Functional pEC50 = 5.4 5.4 -1949 3
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 512 9 4 11 1.1 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4cccc(OC)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
CHEMBL5170857 190085 None 0 Human Functional pEC50 = 5.4 5.4 -1949 3
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 512 9 4 11 1.1 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4cccc(OC)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
168281601 191380 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 594 7 5 11 2.3 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(O)c(OC)c4)nc(C#Cc4ccc(Cl)s4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5190575 191380 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 594 7 5 11 2.3 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(O)c(OC)c4)nc(C#Cc4ccc(Cl)s4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
132991434 180064 None 0 Human Functional pEC50 = 7.4 7.4 -4 4
Irreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay
ChEMBL 564 8 6 12 2.4 OC[C@H]1O[C@@H](n2cnc3c(Nc4ccc(CNC(=S)Nc5ccc(N=C=S)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.6b01561
CHEMBL4746617 180064 None 0 Human Functional pEC50 = 7.4 7.4 -4 4
Irreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay
ChEMBL 564 8 6 12 2.4 OC[C@H]1O[C@@H](n2cnc3c(Nc4ccc(CNC(=S)Nc5ccc(N=C=S)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.6b01561
137650221 157347 None 0 Human Functional pEC50 = 7.4 7.4 -1 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 463 6 3 13 1.2 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccs5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
CHEMBL4076561 157347 None 0 Human Functional pEC50 = 7.4 7.4 -1 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 463 6 3 13 1.2 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccs5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
137650918 157337 None 0 Human Functional pEC50 = 6.4 6.4 -12 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 671 14 6 13 3.4 Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)cc1C(=O)c1ccccc1 10.1021/acs.jmedchem.8b00047
CHEMBL4076495 157337 None 0 Human Functional pEC50 = 6.4 6.4 -12 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 671 14 6 13 3.4 Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)cc1C(=O)c1ccccc1 10.1021/acs.jmedchem.8b00047
137650461 157348 None 0 Human Functional pEC50 = 6.4 6.4 -1 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 857 16 6 13 6.4 CC(=O)Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.8b00047
CHEMBL4076565 157348 None 0 Human Functional pEC50 = 6.4 6.4 -1 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 857 16 6 13 6.4 CC(=O)Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.8b00047
76321824 105741 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Partial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminasePartial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminase
ChEMBL 341 4 3 7 1.3 CCCCC#Cc1nc(NC)c2ncn([C@H]3[C@H](O)[C@H](O)[C@@H]4C[C@@H]43)c2n1 10.1021/jm4015313
CHEMBL3125712 105741 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Partial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminasePartial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular cAMP production preincubated for 45 mins followed by forskolin challenge measured after 15 mins by liquid scintillation counting analysis in presence of rolipram and adenosine deaminase
ChEMBL 341 4 3 7 1.3 CCCCC#Cc1nc(NC)c2ncn([C@H]3[C@H](O)[C@H](O)[C@@H]4C[C@@H]43)c2n1 10.1021/jm4015313
168292629 192159 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 526 10 5 11 1.3 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OCC(C)C)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5202349 192159 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 526 10 5 11 1.3 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OCC(C)C)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
44436080 88674 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human adenosine A3 receptor after 15 to 30 minsAgonist activity at human adenosine A3 receptor after 15 to 30 mins
ChEMBL 308 3 3 9 -1.6 CNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](OC)[C@@H]1O 10.1016/j.bmc.2007.05.056
CHEMBL235742 88674 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human adenosine A3 receptor after 15 to 30 minsAgonist activity at human adenosine A3 receptor after 15 to 30 mins
ChEMBL 308 3 3 9 -1.6 CNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](OC)[C@@H]1O 10.1016/j.bmc.2007.05.056
377 2758 None 42 Human Functional pEC50 = 7.3 7.3 -3 10
Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.2c00320
425 2758 None 42 Human Functional pEC50 = 7.3 7.3 -3 10
Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.2c00320
448222 2758 None 42 Human Functional pEC50 = 7.3 7.3 -3 10
Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.2c00320
CHEMBL464859 2758 None 42 Human Functional pEC50 = 7.3 7.3 -3 10
Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.2c00320
10407895 79249 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptorEffective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptor
ChEMBL 387 6 3 9 1.4 CSC[C@H]1O[C@@H](n2cnc3c(NCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm981090+
CHEMBL2113420 79249 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptorEffective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptor
ChEMBL 387 6 3 9 1.4 CSC[C@H]1O[C@@H](n2cnc3c(NCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm981090+
168276950 190406 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 540 11 5 11 1.6 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OCCC(C)C)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5175945 190406 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 540 11 5 11 1.6 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OCCC(C)C)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
76322076 106104 None 0 Human Functional pEC50 = 8.3 8.3 39 4
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 489 7 5 10 1.0 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(N)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
CHEMBL3133080 106104 None 0 Human Functional pEC50 = 8.3 8.3 39 4
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 489 7 5 10 1.0 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(N)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
76332919 106111 None 0 Human Functional pEC50 = 8.3 8.3 316 3
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 323 3 5 10 -2.2 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC)nc(N)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
CHEMBL3133153 106111 None 0 Human Functional pEC50 = 8.3 8.3 316 3
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 323 3 5 10 -2.2 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC)nc(N)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
76318403 106115 None 0 Human Functional pEC50 = 8.3 8.3 12 4
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 363 4 5 10 -1.3 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCC4)nc(N)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
CHEMBL3133157 106115 None 0 Human Functional pEC50 = 8.3 8.3 12 4
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 363 4 5 10 -1.3 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCC4)nc(N)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
57523213 2673 None 20 Human Functional pEC50 = 8.3 8.3 - 1
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay
ChEMBL 564 5 4 8 2.8 CNC(=O)[C@@]12C[C@@H]1[C@H]([C@@H]([C@@H]2O)O)n1cnc2c1nc(C#Cc1ccc(c(c1)F)F)nc2NCc1cccc(c1)Cl 10.1021/acs.jmedchem.8b00435
8421 2673 None 20 Human Functional pEC50 = 8.3 8.3 - 1
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay
ChEMBL 564 5 4 8 2.8 CNC(=O)[C@@]12C[C@@H]1[C@H]([C@@H]([C@@H]2O)O)n1cnc2c1nc(C#Cc1ccc(c(c1)F)F)nc2NCc1cccc(c1)Cl 10.1021/acs.jmedchem.8b00435
CHEMBL2064657 2673 None 20 Human Functional pEC50 = 8.3 8.3 - 1
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay
ChEMBL 564 5 4 8 2.8 CNC(=O)[C@@]12C[C@@H]1[C@H]([C@@H]([C@@H]2O)O)n1cnc2c1nc(C#Cc1ccc(c(c1)F)F)nc2NCc1cccc(c1)Cl 10.1021/acs.jmedchem.8b00435
10254700 205984 None 5 Human Functional pEC50 = 8.3 8.3 2 3
Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorStimulation of [35S]GTP-gamma-S, against human adenosine A3 receptor
ChEMBL 483 5 4 9 0.7 OC[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm9905965
CHEMBL66393 205984 None 5 Human Functional pEC50 = 8.3 8.3 2 3
Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorStimulation of [35S]GTP-gamma-S, against human adenosine A3 receptor
ChEMBL 483 5 4 9 0.7 OC[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm9905965
162650156 180176 None 0 Rat Functional pEC50 = 8.3 8.3 - 1
Antagonist activity at rat A3AR expressed in CHO cells assessed as reduction in NECA-induced inhibition of forskolin-stimulated cAMP accumulation incubated for 2 hrs by fluorescence based assayAntagonist activity at rat A3AR expressed in CHO cells assessed as reduction in NECA-induced inhibition of forskolin-stimulated cAMP accumulation incubated for 2 hrs by fluorescence based assay
ChEMBL 524 5 1 7 6.7 O=C(Nc1nc(-c2ccccc2)c(-c2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)s1)c1ccco1 10.1016/j.ejmech.2019.111879
CHEMBL4747947 180176 None 0 Rat Functional pEC50 = 8.3 8.3 - 1
Antagonist activity at rat A3AR expressed in CHO cells assessed as reduction in NECA-induced inhibition of forskolin-stimulated cAMP accumulation incubated for 2 hrs by fluorescence based assayAntagonist activity at rat A3AR expressed in CHO cells assessed as reduction in NECA-induced inhibition of forskolin-stimulated cAMP accumulation incubated for 2 hrs by fluorescence based assay
ChEMBL 524 5 1 7 6.7 O=C(Nc1nc(-c2ccccc2)c(-c2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)s1)c1ccco1 10.1016/j.ejmech.2019.111879
118732974 118579 None 0 Human Functional pEC50 = 8.3 8.3 -2 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 373 5 3 12 -0.6 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CC5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
CHEMBL3414940 118579 None 0 Human Functional pEC50 = 8.3 8.3 -2 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 373 5 3 12 -0.6 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CC5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
44359364 30640 None 0 Human Functional pEC50 = 8.3 8.3 - 1
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 520 5 4 8 1.1 CNC(=O)C12CC1C(n1cnc3c(NCc4cccc(I)c4)ncnc31)C(O)C2O 10.1021/jm020211+
CHEMBL139417 30640 None 0 Human Functional pEC50 = 8.3 8.3 - 1
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 520 5 4 8 1.1 CNC(=O)C12CC1C(n1cnc3c(NCc4cccc(I)c4)ncnc31)C(O)C2O 10.1021/jm020211+
9996279 110411 None 0 Human Functional pEC50 = 8.3 8.3 - 1
Effective concentration for inhibition of NECA-stimulated [35S]GTP-gamma-S, binding at human adenosine A3 receptor expressed in CHO cellsEffective concentration for inhibition of NECA-stimulated [35S]GTP-gamma-S, binding at human adenosine A3 receptor expressed in CHO cells
ChEMBL 323 2 1 7 1.2 O=c1[nH]c2ccccc2n2c(=O)n(-c3ccc([N+](=O)[O-])cc3)nc12 10.1021/jm031136l
CHEMBL324095 110411 None 0 Human Functional pEC50 = 8.3 8.3 - 1
Effective concentration for inhibition of NECA-stimulated [35S]GTP-gamma-S, binding at human adenosine A3 receptor expressed in CHO cellsEffective concentration for inhibition of NECA-stimulated [35S]GTP-gamma-S, binding at human adenosine A3 receptor expressed in CHO cells
ChEMBL 323 2 1 7 1.2 O=c1[nH]c2ccccc2n2c(=O)n(-c3ccc([N+](=O)[O-])cc3)nc12 10.1021/jm031136l
16109362 137892 None 0 Human Functional pEC50 = 7.3 7.3 -48 2
Agonist activity at A3 adenosine receptor (unknown origin)Agonist activity at A3 adenosine receptor (unknown origin)
ChEMBL 883 20 6 14 4.3 O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O 10.1021/acs.jmedchem.0c02067
CHEMBL375965 137892 None 0 Human Functional pEC50 = 7.3 7.3 -48 2
Agonist activity at A3 adenosine receptor (unknown origin)Agonist activity at A3 adenosine receptor (unknown origin)
ChEMBL 883 20 6 14 4.3 O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O 10.1021/acs.jmedchem.0c02067
168277923 190788 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 484 8 5 11 0.2 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OC)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5181821 190788 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 484 8 5 11 0.2 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OC)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
168292629 192159 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 526 10 5 11 1.3 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OCC(C)C)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5202349 192159 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 526 10 5 11 1.3 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OCC(C)C)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
118732974 118579 None 0 Human Functional pEC50 = 7.3 7.3 -2 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 373 5 3 12 -0.6 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CC5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
CHEMBL3414940 118579 None 0 Human Functional pEC50 = 7.3 7.3 -2 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 373 5 3 12 -0.6 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CC5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
168290627 192112 None 0 Human Functional pEC50 = 6.3 6.3 -3 4
Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assay
ChEMBL 859 11 6 13 6.6 Nc1sc(-c2ccc(C(=O)NCCC#Cc3ccc(Nc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)cc3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.2c00320
CHEMBL5201533 192112 None 0 Human Functional pEC50 = 6.3 6.3 -3 4
Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assay
ChEMBL 859 11 6 13 6.6 Nc1sc(-c2ccc(C(=O)NCCC#Cc3ccc(Nc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)cc3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.2c00320
137641990 158171 None 0 Human Functional pEC50 = 7.3 7.3 1 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 447 6 3 13 0.7 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5ccco5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
CHEMBL4086325 158171 None 0 Human Functional pEC50 = 7.3 7.3 1 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 447 6 3 13 0.7 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5ccco5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
9850648 98203 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, by activation of human A3AR receptorAgonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, by activation of human A3AR receptor
ChEMBL 554 5 4 8 1.7 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(I)c4)nc(Cl)nc31)[C@H](O)[C@@H]2O 10.1016/s0960-894x(01)00213-x
CHEMBL27376 98203 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, by activation of human A3AR receptorAgonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, by activation of human A3AR receptor
ChEMBL 554 5 4 8 1.7 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(I)c4)nc(Cl)nc31)[C@H](O)[C@@H]2O 10.1016/s0960-894x(01)00213-x
71355811 79234 None 6 Human Functional pEC50 = 7.3 7.3 1348 2
Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as cAMP level measured after 35 mins by cAMP enzyme immunoassayAgonist activity at human adenosine A3 receptor transfected in CHO cells assessed as cAMP level measured after 35 mins by cAMP enzyme immunoassay
ChEMBL 399 8 4 9 0.9 OC[C@H]1O[C@@H](n2cnc3c(NCCCCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O 10.1016/j.ejmech.2021.113607
CHEMBL2113406 79234 None 6 Human Functional pEC50 = 7.3 7.3 1348 2
Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as cAMP level measured after 35 mins by cAMP enzyme immunoassayAgonist activity at human adenosine A3 receptor transfected in CHO cells assessed as cAMP level measured after 35 mins by cAMP enzyme immunoassay
ChEMBL 399 8 4 9 0.9 OC[C@H]1O[C@@H](n2cnc3c(NCCCCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O 10.1016/j.ejmech.2021.113607
162650156 180176 None 0 Rat Functional pEC50 = 7.3 7.3 - 1
Antagonist activity at rat A3AR expressed in CHO cells assessed as reduction in NECA-induced inhibition of forskolin-stimulated cAMP accumulation at 3 uM incubated for 2 hrs by fluorescence based assayAntagonist activity at rat A3AR expressed in CHO cells assessed as reduction in NECA-induced inhibition of forskolin-stimulated cAMP accumulation at 3 uM incubated for 2 hrs by fluorescence based assay
ChEMBL 524 5 1 7 6.7 O=C(Nc1nc(-c2ccccc2)c(-c2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)s1)c1ccco1 10.1016/j.ejmech.2019.111879
CHEMBL4747947 180176 None 0 Rat Functional pEC50 = 7.3 7.3 - 1
Antagonist activity at rat A3AR expressed in CHO cells assessed as reduction in NECA-induced inhibition of forskolin-stimulated cAMP accumulation at 3 uM incubated for 2 hrs by fluorescence based assayAntagonist activity at rat A3AR expressed in CHO cells assessed as reduction in NECA-induced inhibition of forskolin-stimulated cAMP accumulation at 3 uM incubated for 2 hrs by fluorescence based assay
ChEMBL 524 5 1 7 6.7 O=C(Nc1nc(-c2ccccc2)c(-c2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)s1)c1ccco1 10.1016/j.ejmech.2019.111879
168286257 191705 None 0 Human Functional pEC50 = 6.2 6.2 -11 4
Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assay
ChEMBL 863 14 6 13 6.3 Nc1sc(-c2ccc(C(=O)NCCc3ccc(CCNc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)cc3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.2c00320
CHEMBL5195260 191705 None 0 Human Functional pEC50 = 6.2 6.2 -11 4
Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assay
ChEMBL 863 14 6 13 6.3 Nc1sc(-c2ccc(C(=O)NCCc3ccc(CCNc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)cc3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.2c00320
137642153 158460 None 0 Human Functional pEC50 = 7.2 7.2 -4 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 429 6 3 13 0.5 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccs5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
CHEMBL4089741 158460 None 0 Human Functional pEC50 = 7.2 7.2 -4 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 429 6 3 13 0.5 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccs5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
118732972 118577 None 0 Human Functional pEC50 = 8.2 8.2 15 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 347 4 3 12 -1.1 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
CHEMBL3414938 118577 None 0 Human Functional pEC50 = 8.2 8.2 15 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 347 4 3 12 -1.1 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
118732978 118583 None 0 Human Functional pEC50 = 7.2 7.2 -7 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 403 5 3 13 -0.6 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CCCO5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
CHEMBL3414944 118583 None 0 Human Functional pEC50 = 7.2 7.2 -7 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 403 5 3 13 -0.6 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CCCO5)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
76325693 106106 None 0 Human Functional pEC50 = 6.2 6.2 7 2
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 405 5 4 10 -0.4 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(N(C)C)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
CHEMBL3133082 106106 None 0 Human Functional pEC50 = 6.2 6.2 7 2
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
ChEMBL 405 5 4 10 -0.4 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(N(C)C)nc32)[C@H](O)[C@@H]1O 10.1039/C3MD00364G
168293013 192218 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 548 6 4 9 2.6 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccccc4)nc(C#Cc4ccc(Cl)s4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5203255 192218 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 548 6 4 9 2.6 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccccc4)nc(C#Cc4ccc(Cl)s4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
137653409 159129 None 0 Human Functional pEC50 = 7.2 7.2 -1 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 567 12 6 12 2.2 Nc1ccc(-c2cccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2)s1 10.1021/acs.jmedchem.8b00047
CHEMBL4096796 159129 None 0 Human Functional pEC50 = 7.2 7.2 -1 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 567 12 6 12 2.2 Nc1ccc(-c2cccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2)s1 10.1021/acs.jmedchem.8b00047
168293013 192218 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 548 6 4 9 2.6 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccccc4)nc(C#Cc4ccc(Cl)s4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5203255 192218 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 548 6 4 9 2.6 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccccc4)nc(C#Cc4ccc(Cl)s4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
168285878 191742 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 594 8 4 10 1.1 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(OC)c4)nc(I)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5195772 191742 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
ChEMBL 594 8 4 10 1.1 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(OC)c4)nc(I)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
168269866 190097 None 0 Human Functional pEC50 = 7.2 7.2 -229 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 468 7 4 10 1.0 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccccc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
CHEMBL5171042 190097 None 0 Human Functional pEC50 = 7.2 7.2 -229 4
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 468 7 4 10 1.0 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccccc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
10256116 99136 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, by activation of human A3AR receptorAgonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, by activation of human A3AR receptor
ChEMBL 520 5 4 8 1.1 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(I)c4)ncnc31)[C@H](O)[C@@H]2O 10.1016/s0960-894x(01)00213-x
CHEMBL280580 99136 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, by activation of human A3AR receptorAgonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, by activation of human A3AR receptor
ChEMBL 520 5 4 8 1.1 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(I)c4)ncnc31)[C@H](O)[C@@H]2O 10.1016/s0960-894x(01)00213-x
168276950 190406 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 540 11 5 11 1.6 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OCCC(C)C)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5175945 190406 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 540 11 5 11 1.6 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OCCC(C)C)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
155540779 172618 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Partial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assayPartial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assay
ChEMBL 581 6 4 10 3.3 COc1cc(CCNc2nc(C#Cc3ccc(Br)s3)nc3c2ncn3[C@H]2[C@H](O)[C@H](O)[C@@H]3C[C@@H]32)ccc1O 10.1021/acs.jmedchem.0c00235
CHEMBL4483546 172618 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Partial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assayPartial agonist activity at recombinant human A3AR expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins in presence of A2BAR blocker PSB-603 by Glo-sensor assay
ChEMBL 581 6 4 10 3.3 COc1cc(CCNc2nc(C#Cc3ccc(Br)s3)nc3c2ncn3[C@H]2[C@H](O)[C@H](O)[C@@H]3C[C@@H]32)ccc1O 10.1021/acs.jmedchem.0c00235
137661132 159268 None 0 Human Functional pEC50 = 8.1 8.1 2 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 491 6 3 12 1.7 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(Cl)c5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
CHEMBL4098377 159268 None 0 Human Functional pEC50 = 8.1 8.1 2 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 491 6 3 12 1.7 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(Cl)c5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
118732973 118578 None 0 Human Functional pEC50 = 8.1 8.1 30 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 381 4 3 12 -0.5 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
CHEMBL3414939 118578 None 0 Human Functional pEC50 = 8.1 8.1 30 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 381 4 3 12 -0.5 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
57523251 76727 None 0 Human Functional pEC50 = 8.1 8.1 - 1
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay
ChEMBL 604 6 4 8 4.2 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(Cl)c4)nc(C#Cc4ccc(-c5ccccc5)cc4)nc31)[C@H](O)[C@@H]2O 10.1021/acs.jmedchem.8b00435
CHEMBL2064660 76727 None 0 Human Functional pEC50 = 8.1 8.1 - 1
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assayAgonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-mediated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by alphascreen assay
ChEMBL 604 6 4 8 4.2 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(Cl)c4)nc(C#Cc4ccc(-c5ccccc5)cc4)nc31)[C@H](O)[C@@H]2O 10.1021/acs.jmedchem.8b00435
118732977 118582 None 0 Human Functional pEC50 = 6.1 6.1 -70 3
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 461 5 3 12 1.1 CCn1nnc([C@H]2O[C@@H](n3cnc4c(N[C@H]5C[C@@H]6CC[C@@H]5C6)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
CHEMBL3414943 118582 None 0 Human Functional pEC50 = 6.1 6.1 -70 3
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 461 5 3 12 1.1 CCn1nnc([C@H]2O[C@@H](n3cnc4c(N[C@H]5C[C@@H]6CC[C@@H]5C6)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
168285878 191742 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 594 8 4 10 1.1 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(OC)c4)nc(I)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5195772 191742 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 594 8 4 10 1.1 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(OC)c4)nc(I)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
377 2758 None 42 Human Functional pEC50 = 7.1 7.1 -3 10
Activity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayActivity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm050968b
425 2758 None 42 Human Functional pEC50 = 7.1 7.1 -3 10
Activity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayActivity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm050968b
448222 2758 None 42 Human Functional pEC50 = 7.1 7.1 -3 10
Activity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayActivity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm050968b
CHEMBL464859 2758 None 42 Human Functional pEC50 = 7.1 7.1 -3 10
Activity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayActivity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm050968b
168293564 192266 None 0 Human Functional pEC50 = 6.1 6.1 -125 4
Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assay
ChEMBL 849 13 6 13 6.8 Nc1sc(-c2ccc(C(=O)NCCCc3ccc(Nc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)cc3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.2c00320
CHEMBL5203917 192266 None 0 Human Functional pEC50 = 6.1 6.1 -125 4
Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assay
ChEMBL 849 13 6 13 6.8 Nc1sc(-c2ccc(C(=O)NCCCc3ccc(Nc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)cc3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.2c00320
71657835 159831 None 4 Human Functional pEC50 = 6.1 6.1 -7 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 815 15 6 13 6.1 Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.8b00047
CHEMBL4104819 159831 None 4 Human Functional pEC50 = 6.1 6.1 -7 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 815 15 6 13 6.1 Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.8b00047
380 1287 None 37 Human Functional pEC50 = 5.1 5.1 -724 5
Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorStimulation of [35S]GTP-gamma-S, against human adenosine A3 receptor
ChEMBL 335 4 4 9 -0.2 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1 10.1021/jm9905965
657378 1287 None 37 Human Functional pEC50 = 5.1 5.1 -724 5
Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorStimulation of [35S]GTP-gamma-S, against human adenosine A3 receptor
ChEMBL 335 4 4 9 -0.2 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1 10.1021/jm9905965
CHEMBL68738 1287 None 37 Human Functional pEC50 = 5.1 5.1 -724 5
Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorStimulation of [35S]GTP-gamma-S, against human adenosine A3 receptor
ChEMBL 335 4 4 9 -0.2 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1 10.1021/jm9905965
11962166 77906 None 0 Human Functional pEC50 = 8.1 8.1 - 1
Inhibition of isoproterenol-induced increase of cAMP in HEK293 cell expressing human adenosine A3 receptorInhibition of isoproterenol-induced increase of cAMP in HEK293 cell expressing human adenosine A3 receptor
ChEMBL 559 8 5 12 -0.8 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cc(Cl)ccc4OCC(=O)N4CCNCC4)ncnc32)[C@H](O)[C@@H]1N 10.1016/j.bmcl.2006.01.088
CHEMBL209352 77906 None 0 Human Functional pEC50 = 8.1 8.1 - 1
Inhibition of isoproterenol-induced increase of cAMP in HEK293 cell expressing human adenosine A3 receptorInhibition of isoproterenol-induced increase of cAMP in HEK293 cell expressing human adenosine A3 receptor
ChEMBL 559 8 5 12 -0.8 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cc(Cl)ccc4OCC(=O)N4CCNCC4)ncnc32)[C@H](O)[C@@H]1N 10.1016/j.bmcl.2006.01.088
44359214 116823 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 311 2 4 8 -0.7 Nc1nc(Cl)nc2c1ncn2C1C(O)C(O)C2(CO)CC12 10.1021/jm020211+
CHEMBL337602 116823 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 311 2 4 8 -0.7 Nc1nc(Cl)nc2c1ncn2C1C(O)C(O)C2(CO)CC12 10.1021/jm020211+
11743031 29835 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 423 8 3 10 -0.7 CCCCn1c(=O)c2c(ncn2[C@@H]2O[C@H](C(=O)NC)[C@@H](O)[C@H]2O)n(CCCC)c1=O 10.1021/jm020211+
CHEMBL138746 29835 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 423 8 3 10 -0.7 CCCCn1c(=O)c2c(ncn2[C@@H]2O[C@H](C(=O)NC)[C@@H](O)[C@H]2O)n(CCCC)c1=O 10.1021/jm020211+
118732976 118581 None 0 Human Functional pEC50 = 7.1 7.1 -17 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 427 5 3 12 0.4 CCn1nnc([C@H]2O[C@@H](n3cnc4c(N[C@H]5C[C@@H]6CC[C@@H]5C6)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
CHEMBL3414942 118581 None 0 Human Functional pEC50 = 7.1 7.1 -17 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 427 5 3 12 0.4 CCn1nnc([C@H]2O[C@@H](n3cnc4c(N[C@H]5C[C@@H]6CC[C@@H]5C6)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
137643164 158193 None 0 Human Functional pEC50 = 6.1 6.1 -46 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 552 12 5 11 2.6 O=C(NCCCCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1cccc(-c2cccs2)c1 10.1021/acs.jmedchem.8b00047
CHEMBL4086624 158193 None 0 Human Functional pEC50 = 6.1 6.1 -46 4
Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins followed by forskolin addition measured after 30 mins by Alphascreen assay
ChEMBL 552 12 5 11 2.6 O=C(NCCCCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1cccc(-c2cccs2)c1 10.1021/acs.jmedchem.8b00047
168274691 190648 None 0 Human Functional pEC50 = 5.1 5.1 -457 2
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 519 7 4 10 1.8 OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4cccc(Br)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
CHEMBL5179726 190648 None 0 Human Functional pEC50 = 5.1 5.1 -457 2
Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
ChEMBL 519 7 4 10 1.8 OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4cccc(Br)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.2c01414
377 2758 None 42 Human Functional pEC50 = 7.1 7.1 -3 10
Effective concentration for stimulation of [35S]GTP-gamma-S, binding at human adenosine A3 receptor expressed in CHO cellsEffective concentration for stimulation of [35S]GTP-gamma-S, binding at human adenosine A3 receptor expressed in CHO cells
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm031136l
425 2758 None 42 Human Functional pEC50 = 7.1 7.1 -3 10
Effective concentration for stimulation of [35S]GTP-gamma-S, binding at human adenosine A3 receptor expressed in CHO cellsEffective concentration for stimulation of [35S]GTP-gamma-S, binding at human adenosine A3 receptor expressed in CHO cells
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm031136l
448222 2758 None 42 Human Functional pEC50 = 7.1 7.1 -3 10
Effective concentration for stimulation of [35S]GTP-gamma-S, binding at human adenosine A3 receptor expressed in CHO cellsEffective concentration for stimulation of [35S]GTP-gamma-S, binding at human adenosine A3 receptor expressed in CHO cells
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm031136l
CHEMBL464859 2758 None 42 Human Functional pEC50 = 7.1 7.1 -3 10
Effective concentration for stimulation of [35S]GTP-gamma-S, binding at human adenosine A3 receptor expressed in CHO cellsEffective concentration for stimulation of [35S]GTP-gamma-S, binding at human adenosine A3 receptor expressed in CHO cells
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm031136l
168272014 190319 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 594 12 5 11 3.0 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OCCCC4CCCCC4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
CHEMBL5174613 190319 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assayAgonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay
ChEMBL 594 12 5 11 3.0 CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccc(OC)c(O)c4)nc(OCCCC4CCCCC4)nc31)[C@H](O)[C@@H]2O 10.1016/j.ejmech.2021.113983
10254700 205984 None 5 Human Functional pEC50 = 7.1 7.1 2 3
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 483 5 4 9 0.7 OC[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm020211+
CHEMBL66393 205984 None 5 Human Functional pEC50 = 7.1 7.1 2 3
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorEffect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
ChEMBL 483 5 4 9 0.7 OC[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm020211+
168293183 192235 None 0 Human Functional pEC50 = 6.1 6.1 -1 3
Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assay
ChEMBL 767 16 6 13 4.7 Nc1sc(CCC(=O)NCCCCCCNc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.2c00320
CHEMBL5203535 192235 None 0 Human Functional pEC50 = 6.1 6.1 -1 3
Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by LANCE cAMP assay
ChEMBL 767 16 6 13 4.7 Nc1sc(CCC(=O)NCCCCCCNc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1 10.1021/acs.jmedchem.2c00320
377 2758 None 42 Human Functional pEC50 = 7.1 7.1 -3 10
Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptorEffective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptor
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm981090+
425 2758 None 42 Human Functional pEC50 = 7.1 7.1 -3 10
Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptorEffective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptor
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm981090+
448222 2758 None 42 Human Functional pEC50 = 7.1 7.1 -3 10
Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptorEffective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptor
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm981090+
CHEMBL464859 2758 None 42 Human Functional pEC50 = 7.1 7.1 -3 10
Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptorEffective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptor
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm981090+
137636099 155915 None 0 Human Functional pEC50 = 8.0 8.0 1 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 535 6 3 12 1.9 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(Br)c5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
CHEMBL4059961 155915 None 0 Human Functional pEC50 = 8.0 8.0 1 4
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as reversal of NECA-mediated inhibition of adenylyl cyclase activity after 10 mins by [alpha-32P]ATP assay
ChEMBL 535 6 3 12 1.9 CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(Br)c5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b00291
118732971 118575 None 0 Human Functional pEC50 = 7.0 7.0 -39 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 333 3 3 12 -1.6 CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
CHEMBL3414936 118575 None 0 Human Functional pEC50 = 7.0 7.0 -39 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activityAntagonist activity at human recombinant adenosine A3 receptor transfected in CHO cells assessed as reversal of NECA-induced inhibition of forskolin-induced adenylyl cyclase activity
ChEMBL 333 3 3 12 -1.6 CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.5b00074
3035850 951 None 50 Human Functional pED50 = 7 7.0 -14 2
Activity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channelActivity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channel
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1016/j.bmcl.2006.01.110
3035850.0 951 None 50 Human Functional pED50 = 7 7.0 -14 2
Activity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channelActivity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channel
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1016/j.bmcl.2006.01.110
457 951 None 50 Human Functional pED50 = 7 7.0 -14 2
Activity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channelActivity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channel
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1016/j.bmcl.2006.01.110
CHEMBL431733 951 None 50 Human Functional pED50 = 7 7.0 -14 2
Activity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channelActivity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channel
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1016/j.bmcl.2006.01.110
DB12885 951 None 50 Human Functional pED50 = 7 7.0 -14 2
Activity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channelActivity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channel
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1016/j.bmcl.2006.01.110
11619671 75980 None 0 Human Functional pED50 = 6.9 6.9 - 0
Activity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channelActivity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channel
ChEMBL 466 6 4 10 0.4 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#Cc4ccc(OC)cc4)nc32)[C@H](O)[C@@H]1O 10.1016/j.bmcl.2006.01.110
CHEMBL205225 75980 None 0 Human Functional pED50 = 6.9 6.9 - 0
Activity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channelActivity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channel
ChEMBL 466 6 4 10 0.4 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#Cc4ccc(OC)cc4)nc32)[C@H](O)[C@@H]1O 10.1016/j.bmcl.2006.01.110
123683 3121 None 46 Human Functional pED50 = 7.6 7.6 67 5
Activity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channelActivity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channel
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1016/j.bmcl.2006.01.110
422 3121 None 46 Human Functional pED50 = 7.6 7.6 67 5
Activity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channelActivity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channel
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1016/j.bmcl.2006.01.110
CHEMBL119709 3121 None 46 Human Functional pED50 = 7.6 7.6 67 5
Activity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channelActivity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channel
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1016/j.bmcl.2006.01.110
DB05511 3121 None 46 Human Functional pED50 = 7.6 7.6 67 5
Activity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channelActivity at adenosine A3 receptor expressed in HEK293 cells by inhibition of isoprotenol-stimulated cAMP gated channel
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1016/j.bmcl.2006.01.110
123683 3121 None 46 Human Functional pIC50 = 10.8 10.8 67 5
Agonist activity at wild type human A3 receptor I253'6.58E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I253'6.58E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
422 3121 None 46 Human Functional pIC50 = 10.8 10.8 67 5
Agonist activity at wild type human A3 receptor I253'6.58E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I253'6.58E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
CHEMBL119709 3121 None 46 Human Functional pIC50 = 10.8 10.8 67 5
Agonist activity at wild type human A3 receptor I253'6.58E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I253'6.58E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
DB05511 3121 None 46 Human Functional pIC50 = 10.8 10.8 67 5
Agonist activity at wild type human A3 receptor I253'6.58E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I253'6.58E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
123683 3121 None 46 Human Functional pIC50 = 10.7 10.7 67 5
Agonist activity at wild type human A3 receptor I249'6.54A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I249'6.54A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
422 3121 None 46 Human Functional pIC50 = 10.7 10.7 67 5
Agonist activity at wild type human A3 receptor I249'6.54A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I249'6.54A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
CHEMBL119709 3121 None 46 Human Functional pIC50 = 10.7 10.7 67 5
Agonist activity at wild type human A3 receptor I249'6.54A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I249'6.54A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
DB05511 3121 None 46 Human Functional pIC50 = 10.7 10.7 67 5
Agonist activity at wild type human A3 receptor I249'6.54A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I249'6.54A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
123683 3121 None 46 Human Functional pIC50 = 10.6 10.6 67 5
Agonist activity at wild type human A3 receptor W185'5.46A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor W185'5.46A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
422 3121 None 46 Human Functional pIC50 = 10.6 10.6 67 5
Agonist activity at wild type human A3 receptor W185'5.46A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor W185'5.46A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
CHEMBL119709 3121 None 46 Human Functional pIC50 = 10.6 10.6 67 5
Agonist activity at wild type human A3 receptor W185'5.46A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor W185'5.46A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
DB05511 3121 None 46 Human Functional pIC50 = 10.6 10.6 67 5
Agonist activity at wild type human A3 receptor W185'5.46A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor W185'5.46A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
123683 3121 None 46 Human Functional pIC50 = 10.6 10.6 67 5
Agonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
422 3121 None 46 Human Functional pIC50 = 10.6 10.6 67 5
Agonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
CHEMBL119709 3121 None 46 Human Functional pIC50 = 10.6 10.6 67 5
Agonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
DB05511 3121 None 46 Human Functional pIC50 = 10.6 10.6 67 5
Agonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
123683 3121 None 46 Human Functional pIC50 = 10.3 10.3 67 5
Agonist activity at wild type human A3 receptor I253'6.58A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I253'6.58A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
422 3121 None 46 Human Functional pIC50 = 10.3 10.3 67 5
Agonist activity at wild type human A3 receptor I253'6.58A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I253'6.58A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
CHEMBL119709 3121 None 46 Human Functional pIC50 = 10.3 10.3 67 5
Agonist activity at wild type human A3 receptor I253'6.58A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I253'6.58A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
DB05511 3121 None 46 Human Functional pIC50 = 10.3 10.3 67 5
Agonist activity at wild type human A3 receptor I253'6.58A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I253'6.58A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
123683 3121 None 46 Human Functional pIC50 = 10.3 10.3 67 5
Agonist activity at wild type human A3 receptor L264'7.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor L264'7.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
422 3121 None 46 Human Functional pIC50 = 10.3 10.3 67 5
Agonist activity at wild type human A3 receptor L264'7.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor L264'7.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
CHEMBL119709 3121 None 46 Human Functional pIC50 = 10.3 10.3 67 5
Agonist activity at wild type human A3 receptor L264'7.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor L264'7.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
DB05511 3121 None 46 Human Functional pIC50 = 10.3 10.3 67 5
Agonist activity at wild type human A3 receptor L264'7.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor L264'7.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
46237929 8958 None 0 Human Functional pIC50 = 10.2 10.2 138 2
Antagonist activity at adenosine A3 receptor in human U87MG cells assessed as inhibition of Cl-IB-MECA-mediated ERK1/2 phosphorylation after 30 mins by ELISAAntagonist activity at adenosine A3 receptor in human U87MG cells assessed as inhibition of Cl-IB-MECA-mediated ERK1/2 phosphorylation after 30 mins by ELISA
ChEMBL 359 4 1 6 3.3 COc1ccc(C(=O)Nc2nc(-c3ccccc3)nc3nn(C)cc23)cc1 10.1021/jm901785w
CHEMBL1098108 8958 None 0 Human Functional pIC50 = 10.2 10.2 138 2
Antagonist activity at adenosine A3 receptor in human U87MG cells assessed as inhibition of Cl-IB-MECA-mediated ERK1/2 phosphorylation after 30 mins by ELISAAntagonist activity at adenosine A3 receptor in human U87MG cells assessed as inhibition of Cl-IB-MECA-mediated ERK1/2 phosphorylation after 30 mins by ELISA
ChEMBL 359 4 1 6 3.3 COc1ccc(C(=O)Nc2nc(-c3ccccc3)nc3nn(C)cc23)cc1 10.1021/jm901785w
393595 2637 None 36 Human Functional pIC50 = 10.0 10.0 16 3
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 403 4 1 6 4.4 O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1 10.1021/acs.jmedchem.2c01123
448 2637 None 36 Human Functional pIC50 = 10.0 10.0 16 3
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 403 4 1 6 4.4 O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1 10.1021/acs.jmedchem.2c01123
CHEMBL88147 2637 None 36 Human Functional pIC50 = 10.0 10.0 16 3
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 403 4 1 6 4.4 O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1 10.1021/acs.jmedchem.2c01123
127036560 137613 None 0 Human Functional pIC50 = 10.0 10.0 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 427 5 1 7 4.8 COc1ccc(C(=O)Nc2nc(-c3cccs3)nc3cn(-c4ccccc4)nc23)cc1 10.1016/j.ejmech.2015.11.015
CHEMBL3754229 137613 None 0 Human Functional pIC50 = 10.0 10.0 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 427 5 1 7 4.8 COc1ccc(C(=O)Nc2nc(-c3cccs3)nc3cn(-c4ccccc4)nc23)cc1 10.1016/j.ejmech.2015.11.015
11611903 83129 None 0 Human Functional pIC50 = 9.8 9.8 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 439 6 4 9 1.1 OC[C@H]1O[C@@H](n2cnc3c(C(F)(F)F)nc(NCCc4ccccc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300087j
CHEMBL2181968 83129 None 0 Human Functional pIC50 = 9.8 9.8 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 439 6 4 9 1.1 OC[C@H]1O[C@@H](n2cnc3c(C(F)(F)F)nc(NCCc4ccccc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300087j
377 2758 None 42 Human Functional pIC50 = 9.7 9.7 -3 10
Agonist activity at wild type human A3 receptor V169'5.30E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor V169'5.30E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
425 2758 None 42 Human Functional pIC50 = 9.7 9.7 -3 10
Agonist activity at wild type human A3 receptor V169'5.30E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor V169'5.30E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
448222 2758 None 42 Human Functional pIC50 = 9.7 9.7 -3 10
Agonist activity at wild type human A3 receptor V169'5.30E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor V169'5.30E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
CHEMBL464859 2758 None 42 Human Functional pIC50 = 9.7 9.7 -3 10
Agonist activity at wild type human A3 receptor V169'5.30E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor V169'5.30E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
377 2758 None 42 Human Functional pIC50 = 9.6 9.6 -3 10
Agonist activity at wild type human A3 receptor V169'5.30A/W185'5.46A double mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor V169'5.30A/W185'5.46A double mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
425 2758 None 42 Human Functional pIC50 = 9.6 9.6 -3 10
Agonist activity at wild type human A3 receptor V169'5.30A/W185'5.46A double mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor V169'5.30A/W185'5.46A double mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
448222 2758 None 42 Human Functional pIC50 = 9.6 9.6 -3 10
Agonist activity at wild type human A3 receptor V169'5.30A/W185'5.46A double mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor V169'5.30A/W185'5.46A double mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
CHEMBL464859 2758 None 42 Human Functional pIC50 = 9.6 9.6 -3 10
Agonist activity at wild type human A3 receptor V169'5.30A/W185'5.46A double mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor V169'5.30A/W185'5.46A double mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
377 2758 None 42 Human Functional pIC50 = 9.5 9.5 -3 10
Agonist activity at wild type human A3 receptor I249'6.54A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I249'6.54A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
425 2758 None 42 Human Functional pIC50 = 9.5 9.5 -3 10
Agonist activity at wild type human A3 receptor I249'6.54A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I249'6.54A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
448222 2758 None 42 Human Functional pIC50 = 9.5 9.5 -3 10
Agonist activity at wild type human A3 receptor I249'6.54A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I249'6.54A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
CHEMBL464859 2758 None 42 Human Functional pIC50 = 9.5 9.5 -3 10
Agonist activity at wild type human A3 receptor I249'6.54A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I249'6.54A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
9863617 73544 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Inhibitory concentration against human Adenosine A3 receptor mediated inhibition of cyclic AMP in transfected CHO cellsInhibitory concentration against human Adenosine A3 receptor mediated inhibition of cyclic AMP in transfected CHO cells
ChEMBL 358 3 4 9 -0.4 CNC(=O)[C@H]1S[C@@H](n2cnc3c(NC)nc(Cl)nc32)[C@H](O)[C@@H]1O 10.1021/jm034098e
CHEMBL201706 73544 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Inhibitory concentration against human Adenosine A3 receptor mediated inhibition of cyclic AMP in transfected CHO cellsInhibitory concentration against human Adenosine A3 receptor mediated inhibition of cyclic AMP in transfected CHO cells
ChEMBL 358 3 4 9 -0.4 CNC(=O)[C@H]1S[C@@H](n2cnc3c(NC)nc(Cl)nc32)[C@H](O)[C@@H]1O 10.1021/jm034098e
377 2758 None 42 Human Functional pIC50 = 9.3 9.3 -3 10
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.5b01402
425 2758 None 42 Human Functional pIC50 = 9.3 9.3 -3 10
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.5b01402
448222 2758 None 42 Human Functional pIC50 = 9.3 9.3 -3 10
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.5b01402
CHEMBL464859 2758 None 42 Human Functional pIC50 = 9.3 9.3 -3 10
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.5b01402
377 2758 None 42 Human Functional pIC50 = 9.3 9.3 -3 10
Agonist activity at wild type human A3 receptor V169'5.30A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor V169'5.30A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
425 2758 None 42 Human Functional pIC50 = 9.3 9.3 -3 10
Agonist activity at wild type human A3 receptor V169'5.30A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor V169'5.30A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
448222 2758 None 42 Human Functional pIC50 = 9.3 9.3 -3 10
Agonist activity at wild type human A3 receptor V169'5.30A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor V169'5.30A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
CHEMBL464859 2758 None 42 Human Functional pIC50 = 9.3 9.3 -3 10
Agonist activity at wild type human A3 receptor V169'5.30A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor V169'5.30A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
23656936 154986 None 0 Human Functional pIC50 = 9.2 9.2 2630 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation
ChEMBL 425 4 1 7 3.6 COc1ccc(C(=O)Nc2nc3ccccc3n3c(=O)c(-c4ccc(C)cc4)nn23)cc1 10.1021/jm0708376
CHEMBL400812 154986 None 0 Human Functional pIC50 = 9.2 9.2 2630 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation
ChEMBL 425 4 1 7 3.6 COc1ccc(C(=O)Nc2nc3ccccc3n3c(=O)c(-c4ccc(C)cc4)nn23)cc1 10.1021/jm0708376
377 2758 None 42 Human Functional pIC50 = 9.2 9.2 -3 10
Agonist activity at wild type human A3 receptor I253'6.58E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I253'6.58E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
425 2758 None 42 Human Functional pIC50 = 9.2 9.2 -3 10
Agonist activity at wild type human A3 receptor I253'6.58E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I253'6.58E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
448222 2758 None 42 Human Functional pIC50 = 9.2 9.2 -3 10
Agonist activity at wild type human A3 receptor I253'6.58E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I253'6.58E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
CHEMBL464859 2758 None 42 Human Functional pIC50 = 9.2 9.2 -3 10
Agonist activity at wild type human A3 receptor I253'6.58E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I253'6.58E mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
11813713 73008 None 2 Human Functional pIC50 = 9.2 9.2 - 1
Inhibitory concentration against human Adenosine A3 receptor mediated inhibition of cyclic AMP in transfected CHO cellsInhibitory concentration against human Adenosine A3 receptor mediated inhibition of cyclic AMP in transfected CHO cells
ChEMBL 560 5 4 9 1.8 CNC(=O)[C@H]1S[C@@H](n2cnc3c(NCc4cccc(I)c4)nc(Cl)nc32)[C@H](O)[C@@H]1O 10.1021/jm034098e
CHEMBL200732 73008 None 2 Human Functional pIC50 = 9.2 9.2 - 1
Inhibitory concentration against human Adenosine A3 receptor mediated inhibition of cyclic AMP in transfected CHO cellsInhibitory concentration against human Adenosine A3 receptor mediated inhibition of cyclic AMP in transfected CHO cells
ChEMBL 560 5 4 9 1.8 CNC(=O)[C@H]1S[C@@H](n2cnc3c(NCc4cccc(I)c4)nc(Cl)nc32)[C@H](O)[C@@H]1O 10.1021/jm034098e
135418454 16534 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 360 4 1 5 4.0 CCCCc1nc2[nH]cnc2c2nc(-c3ccc(C(F)(F)F)cc3)nn12 10.1021/jm300087j
CHEMBL123705 16534 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 360 4 1 5 4.0 CCCCc1nc2[nH]cnc2c2nc(-c3ccc(C(F)(F)F)cc3)nn12 10.1021/jm300087j
377 2758 None 42 Human Functional pIC50 = 9.2 9.2 -3 10
Agonist activity at wild type human A3 receptor W185'5.46A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor W185'5.46A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
425 2758 None 42 Human Functional pIC50 = 9.2 9.2 -3 10
Agonist activity at wild type human A3 receptor W185'5.46A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor W185'5.46A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
448222 2758 None 42 Human Functional pIC50 = 9.2 9.2 -3 10
Agonist activity at wild type human A3 receptor W185'5.46A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor W185'5.46A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
CHEMBL464859 2758 None 42 Human Functional pIC50 = 9.2 9.2 -3 10
Agonist activity at wild type human A3 receptor W185'5.46A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor W185'5.46A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
9887859 113576 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 375 3 2 9 2.3 Cn1cc2c(nc(NC(=O)Nc3ccncc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300087j
CHEMBL118923 113576 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 375 3 2 9 2.3 Cn1cc2c(nc(NC(=O)Nc3ccncc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300087j
CHEMBL332091 113576 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 375 3 2 9 2.3 Cn1cc2c(nc(NC(=O)Nc3ccncc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300087j
46237928 8811 None 0 Human Functional pIC50 = 9.1 9.1 42 2
Antagonist activity at adenosine A3 receptor in human U87MG cells assessed as inhibition of Cl-IB-MECA-mediated ERK1/2 phosphorylation after 30 mins by ELISAAntagonist activity at adenosine A3 receptor in human U87MG cells assessed as inhibition of Cl-IB-MECA-mediated ERK1/2 phosphorylation after 30 mins by ELISA
ChEMBL 329 3 1 5 3.3 Cn1cc2c(NC(=O)c3ccccc3)nc(-c3ccccc3)nc2n1 10.1021/jm901785w
CHEMBL1096754 8811 None 0 Human Functional pIC50 = 9.1 9.1 42 2
Antagonist activity at adenosine A3 receptor in human U87MG cells assessed as inhibition of Cl-IB-MECA-mediated ERK1/2 phosphorylation after 30 mins by ELISAAntagonist activity at adenosine A3 receptor in human U87MG cells assessed as inhibition of Cl-IB-MECA-mediated ERK1/2 phosphorylation after 30 mins by ELISA
ChEMBL 329 3 1 5 3.3 Cn1cc2c(NC(=O)c3ccccc3)nc(-c3ccccc3)nc2n1 10.1021/jm901785w
377 2758 None 42 Human Functional pIC50 = 9.1 9.1 -3 10
Agonist activity at wild type human A3 receptor L264'7.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor L264'7.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
425 2758 None 42 Human Functional pIC50 = 9.1 9.1 -3 10
Agonist activity at wild type human A3 receptor L264'7.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor L264'7.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
448222 2758 None 42 Human Functional pIC50 = 9.1 9.1 -3 10
Agonist activity at wild type human A3 receptor L264'7.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor L264'7.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
CHEMBL464859 2758 None 42 Human Functional pIC50 = 9.1 9.1 -3 10
Agonist activity at wild type human A3 receptor L264'7.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor L264'7.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
377 2758 None 42 Human Functional pIC50 = 9.0 9.0 -3 10
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.2c01123
425 2758 None 42 Human Functional pIC50 = 9.0 9.0 -3 10
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.2c01123
448222 2758 None 42 Human Functional pIC50 = 9.0 9.0 -3 10
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.2c01123
CHEMBL464859 2758 None 42 Human Functional pIC50 = 9.0 9.0 -3 10
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.2c01123
11782906 75037 None 0 Human Functional pIC50 = 9 9.0 - 1
Inhibitory concentration against human Adenosine A3 receptor mediated inhibition of cyclic AMP in transfected CHO cellsInhibitory concentration against human Adenosine A3 receptor mediated inhibition of cyclic AMP in transfected CHO cells
ChEMBL 344 2 4 9 -0.9 CNC(=O)[C@H]1S[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O 10.1021/jm034098e
CHEMBL203357 75037 None 0 Human Functional pIC50 = 9 9.0 - 1
Inhibitory concentration against human Adenosine A3 receptor mediated inhibition of cyclic AMP in transfected CHO cellsInhibitory concentration against human Adenosine A3 receptor mediated inhibition of cyclic AMP in transfected CHO cells
ChEMBL 344 2 4 9 -0.9 CNC(=O)[C@H]1S[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O 10.1021/jm034098e
127036564 137539 None 0 Human Functional pIC50 = 9 9.0 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 398 4 1 7 4.2 O=C(Nc1nc(-c2cccs2)nc2cn(-c3ccccc3)nc12)c1cccnc1 10.1016/j.ejmech.2015.11.015
CHEMBL3753642 137539 None 0 Human Functional pIC50 = 9 9.0 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 398 4 1 7 4.2 O=C(Nc1nc(-c2cccs2)nc2cn(-c3ccccc3)nc12)c1cccnc1 10.1016/j.ejmech.2015.11.015
45483968 200526 None 0 Human Functional pIC50 = 9.0 9.0 - 1
Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated 45 mins before forskolin challenge measured after 15 mins by radioimmunoassay relative to NECAAgonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated 45 mins before forskolin challenge measured after 15 mins by radioimmunoassay relative to NECA
ChEMBL 1124 21 6 14 6.8 CCN1/C(=C\C=C\C=C\C2=[N+](CCCCCC(=O)NCCNC(=O)CCC#Cc3nc(NCc4cccc(Cl)c4)c4ncn([C@H]5[C@H](O)[C@H](O)[C@@]6(C(=O)NC)C[C@H]56)c4n3)c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)[O-])ccc21 10.1021/jm900426g
CHEMBL574212 200526 None 0 Human Functional pIC50 = 9.0 9.0 - 1
Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated 45 mins before forskolin challenge measured after 15 mins by radioimmunoassay relative to NECAAgonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated 45 mins before forskolin challenge measured after 15 mins by radioimmunoassay relative to NECA
ChEMBL 1124 21 6 14 6.8 CCN1/C(=C\C=C\C=C\C2=[N+](CCCCCC(=O)NCCNC(=O)CCC#Cc3nc(NCc4cccc(Cl)c4)c4ncn([C@H]5[C@H](O)[C@H](O)[C@@]6(C(=O)NC)C[C@H]56)c4n3)c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)[O-])ccc21 10.1021/jm900426g
2844 283 None 61 Human Functional pIC50 = 8.9 8.9 -1 5
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.5b01402
60961 283 None 61 Human Functional pIC50 = 8.9 8.9 -1 5
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.5b01402
60961.0 283 None 61 Human Functional pIC50 = 8.9 8.9 -1 5
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.5b01402
90 283 None 61 Human Functional pIC50 = 8.9 8.9 -1 5
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.5b01402
CHEMBL477 283 None 61 Human Functional pIC50 = 8.9 8.9 -1 5
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.5b01402
DB00640 283 None 61 Human Functional pIC50 = 8.9 8.9 -1 5
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.5b01402
377 2758 None 42 Human Functional pIC50 = 8.9 8.9 -3 10
Agonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
425 2758 None 42 Human Functional pIC50 = 8.9 8.9 -3 10
Agonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
448222 2758 None 42 Human Functional pIC50 = 8.9 8.9 -3 10
Agonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
CHEMBL464859 2758 None 42 Human Functional pIC50 = 8.9 8.9 -3 10
Agonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
52936298 61293 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 minsAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 mins
ChEMBL 370 4 2 4 3.7 O=C(NCc1ccccc1)Nc1nn(-c2ccccc2)c(=O)c2ccccc12 10.1021/jm101328n
CHEMBL1766359 61293 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 minsAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 mins
ChEMBL 370 4 2 4 3.7 O=C(NCc1ccccc1)Nc1nn(-c2ccccc2)c(=O)c2ccccc12 10.1021/jm101328n
377 2758 None 42 Human Functional pIC50 = 8.9 8.9 -3 10
Agonist activity at wild type human A3 receptor I253'6.58A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I253'6.58A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
425 2758 None 42 Human Functional pIC50 = 8.9 8.9 -3 10
Agonist activity at wild type human A3 receptor I253'6.58A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I253'6.58A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
448222 2758 None 42 Human Functional pIC50 = 8.9 8.9 -3 10
Agonist activity at wild type human A3 receptor I253'6.58A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I253'6.58A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
CHEMBL464859 2758 None 42 Human Functional pIC50 = 8.9 8.9 -3 10
Agonist activity at wild type human A3 receptor I253'6.58A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor I253'6.58A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
3035850 951 None 50 Human Functional pIC50 = 8.9 8.9 -14 2
Agonist activity at human recombinant A3AR expressed in CHO cells assessed as inhibition of forskolin-induced stimulation of cAMP productionAgonist activity at human recombinant A3AR expressed in CHO cells assessed as inhibition of forskolin-induced stimulation of cAMP production
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1016/j.bmc.2014.05.036
3035850.0 951 None 50 Human Functional pIC50 = 8.9 8.9 -14 2
Agonist activity at human recombinant A3AR expressed in CHO cells assessed as inhibition of forskolin-induced stimulation of cAMP productionAgonist activity at human recombinant A3AR expressed in CHO cells assessed as inhibition of forskolin-induced stimulation of cAMP production
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1016/j.bmc.2014.05.036
457 951 None 50 Human Functional pIC50 = 8.9 8.9 -14 2
Agonist activity at human recombinant A3AR expressed in CHO cells assessed as inhibition of forskolin-induced stimulation of cAMP productionAgonist activity at human recombinant A3AR expressed in CHO cells assessed as inhibition of forskolin-induced stimulation of cAMP production
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1016/j.bmc.2014.05.036
CHEMBL431733 951 None 50 Human Functional pIC50 = 8.9 8.9 -14 2
Agonist activity at human recombinant A3AR expressed in CHO cells assessed as inhibition of forskolin-induced stimulation of cAMP productionAgonist activity at human recombinant A3AR expressed in CHO cells assessed as inhibition of forskolin-induced stimulation of cAMP production
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1016/j.bmc.2014.05.036
DB12885 951 None 50 Human Functional pIC50 = 8.9 8.9 -14 2
Agonist activity at human recombinant A3AR expressed in CHO cells assessed as inhibition of forskolin-induced stimulation of cAMP productionAgonist activity at human recombinant A3AR expressed in CHO cells assessed as inhibition of forskolin-induced stimulation of cAMP production
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1016/j.bmc.2014.05.036
24768450 167280 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as reversal of NECA-mediated inhibition of forskolin-induced cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as reversal of NECA-mediated inhibition of forskolin-induced cAMP accumulation
ChEMBL 331 8 1 5 3.6 CCCSc1nc(NC(C)=O)cc(OCCc2ccccc2)n1 10.1021/jm701159t
CHEMBL429131 167280 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as reversal of NECA-mediated inhibition of forskolin-induced cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as reversal of NECA-mediated inhibition of forskolin-induced cAMP accumulation
ChEMBL 331 8 1 5 3.6 CCCSc1nc(NC(C)=O)cc(OCCc2ccccc2)n1 10.1021/jm701159t
44436081 166861 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at human adenosine A3 receptor after 15 to 30 minsAntagonist activity at human adenosine A3 receptor after 15 to 30 mins
ChEMBL 497 6 3 9 1.3 CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(NCc3cccc(I)c3)ncnc21 10.1016/j.bmc.2007.05.056
CHEMBL428377 166861 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at human adenosine A3 receptor after 15 to 30 minsAntagonist activity at human adenosine A3 receptor after 15 to 30 mins
ChEMBL 497 6 3 9 1.3 CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(NCc3cccc(I)c3)ncnc21 10.1016/j.bmc.2007.05.056
135423046 37715 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of cAMP accumulation in CHO cells expressing human A3 adenosine receptorInhibition of cAMP accumulation in CHO cells expressing human A3 adenosine receptor
ChEMBL 390 4 3 8 2.9 COc1ccc(NC(=O)Nc2nc3n[nH]cc3c3nc(-c4ccco4)nn23)cc1 10.1021/jm001047y
CHEMBL145767 37715 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of cAMP accumulation in CHO cells expressing human A3 adenosine receptorInhibition of cAMP accumulation in CHO cells expressing human A3 adenosine receptor
ChEMBL 390 4 3 8 2.9 COc1ccc(NC(=O)Nc2nc3n[nH]cc3c3nc(-c4ccco4)nn23)cc1 10.1021/jm001047y
24768452 98048 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as reversal of NECA-mediated inhibition of forskolin-induced cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as reversal of NECA-mediated inhibition of forskolin-induced cAMP accumulation
ChEMBL 337 6 1 5 3.8 CCSc1nc(NC(C)=O)cc(OCc2ccc(Cl)cc2)n1 10.1021/jm701159t
CHEMBL272795 98048 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as reversal of NECA-mediated inhibition of forskolin-induced cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as reversal of NECA-mediated inhibition of forskolin-induced cAMP accumulation
ChEMBL 337 6 1 5 3.8 CCSc1nc(NC(C)=O)cc(OCc2ccc(Cl)cc2)n1 10.1021/jm701159t
46237928 8811 None 0 Human Functional pIC50 = 8.7 8.7 42 2
Antagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry
ChEMBL 329 3 1 5 3.3 Cn1cc2c(NC(=O)c3ccccc3)nc(-c3ccccc3)nc2n1 10.1021/jm901785w
CHEMBL1096754 8811 None 0 Human Functional pIC50 = 8.7 8.7 42 2
Antagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry
ChEMBL 329 3 1 5 3.3 Cn1cc2c(NC(=O)c3ccccc3)nc(-c3ccccc3)nc2n1 10.1021/jm901785w
168283522 191187 None 0 Human Functional pIC50 = 8.7 8.7 5 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 325 5 2 7 2.6 COc1cc(Nc2nc(C#N)cc3cn[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
CHEMBL5187501 191187 None 0 Human Functional pIC50 = 8.7 8.7 5 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 325 5 2 7 2.6 COc1cc(Nc2nc(C#N)cc3cn[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
136026133 63636 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 355 5 1 6 1.8 C=CCN1C(=O)N2C[C@H](CC)N=C2c2[nH]c(-c3cc(OC)nn3C)nc21 10.1021/jm2004738
CHEMBL1800784 63636 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 355 5 1 6 1.8 C=CCN1C(=O)N2C[C@H](CC)N=C2c2[nH]c(-c3cc(OC)nn3C)nc21 10.1021/jm2004738
10859484 77687 None 0 Human Functional pIC50 = 7.0 7.0 -2 2
Antagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECAAntagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECA
ChEMBL 298 3 2 9 1.3 CCNc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1C 10.1021/jm021023m
CHEMBL20888 77687 None 0 Human Functional pIC50 = 7.0 7.0 -2 2
Antagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECAAntagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECA
ChEMBL 298 3 2 9 1.3 CCNc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1C 10.1021/jm021023m
CHEMBL544678 77687 None 0 Human Functional pIC50 = 7.0 7.0 -2 2
Antagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECAAntagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECA
ChEMBL 298 3 2 9 1.3 CCNc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1C 10.1021/jm021023m
71601930 86967 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Inhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECAInhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECA
ChEMBL 329 3 1 5 3.4 CC(=O)Nc1nc(-c2ccccc2)nc2cn(-c3ccccc3)nc12 10.1021/jm400068e
CHEMBL2322929 86967 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Inhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECAInhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECA
ChEMBL 329 3 1 5 3.4 CC(=O)Nc1nc(-c2ccccc2)nc2cn(-c3ccccc3)nc12 10.1021/jm400068e
149362 75503 None 4 Human Functional pIC50 = 7.0 7.0 -8 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 427 7 5 10 -0.2 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccccc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
CHEMBL2042298 75503 None 4 Human Functional pIC50 = 7.0 7.0 -8 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 427 7 5 10 -0.2 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccccc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
60155716 76993 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 419 4 2 9 1.5 C#CCN1CCC(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)CC1 10.1021/jm300323t
CHEMBL2070884 76993 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 419 4 2 9 1.5 C#CCN1CCC(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)CC1 10.1021/jm300323t
44570109 192088 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay
ChEMBL 365 3 1 5 4.2 O=C(Nc1nc2ccccc2c2cn(-c3ccccc3)nc12)c1ccccn1 10.1016/j.bmc.2008.10.018
CHEMBL520122 192088 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay
ChEMBL 365 3 1 5 4.2 O=C(Nc1nc2ccccc2c2cn(-c3ccccc3)nc12)c1ccccn1 10.1016/j.bmc.2008.10.018
377 2758 None 42 Human Functional pIC50 = 7.0 7.0 -3 10
Agonist activity at wild type human A3 receptor M177'5.38A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor M177'5.38A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
425 2758 None 42 Human Functional pIC50 = 7.0 7.0 -3 10
Agonist activity at wild type human A3 receptor M177'5.38A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor M177'5.38A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
448222 2758 None 42 Human Functional pIC50 = 7.0 7.0 -3 10
Agonist activity at wild type human A3 receptor M177'5.38A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor M177'5.38A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
CHEMBL464859 2758 None 42 Human Functional pIC50 = 7.0 7.0 -3 10
Agonist activity at wild type human A3 receptor M177'5.38A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor M177'5.38A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
123807 871 None 35 Human Functional pIC50 = 8.0 8.0 -1 7
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 369 4 4 9 0.4 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1 10.1021/acs.jmedchem.5b01402
374 871 None 35 Human Functional pIC50 = 8.0 8.0 -1 7
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 369 4 4 9 0.4 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1 10.1021/acs.jmedchem.5b01402
379 871 None 35 Human Functional pIC50 = 8.0 8.0 -1 7
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 369 4 4 9 0.4 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1 10.1021/acs.jmedchem.5b01402
CHEMBL284969 871 None 35 Human Functional pIC50 = 8.0 8.0 -1 7
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 369 4 4 9 0.4 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1 10.1021/acs.jmedchem.5b01402
23657266 88664 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation
ChEMBL 459 4 1 7 4.2 COc1ccc(C(=O)Nc2nc3ccc(Cl)cc3n3c(=O)c(-c4ccc(C)cc4)nn23)cc1 10.1021/jm0708376
CHEMBL235717 88664 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation
ChEMBL 459 4 1 7 4.2 COc1ccc(C(=O)Nc2nc3ccc(Cl)cc3n3c(=O)c(-c4ccc(C)cc4)nn23)cc1 10.1021/jm0708376
57385043 75515 None 0 Human Functional pIC50 = 7.0 7.0 -1 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 810 18 6 13 6.1 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(NC(=O)CCCC[C@H]5CCSS5)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
CHEMBL2042310 75515 None 0 Human Functional pIC50 = 7.0 7.0 -1 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 810 18 6 13 6.1 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(NC(=O)CCCC[C@H]5CCSS5)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
71602203 86953 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Inhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECAInhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECA
ChEMBL 433 4 0 6 4.6 Cc1nc(N(C(=O)c2ccccc2)C(=O)c2ccccc2)c2nn(-c3ccccc3)cc2n1 10.1021/jm400068e
CHEMBL2322909 86953 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Inhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECAInhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECA
ChEMBL 433 4 0 6 4.6 Cc1nc(N(C(=O)c2ccccc2)C(=O)c2ccccc2)c2nn(-c3ccccc3)cc2n1 10.1021/jm400068e
60156003 77006 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 452 4 3 9 1.6 CCNC(=O)N1CCC(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)CC1 10.1021/jm300323t
CHEMBL2071039 77006 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 452 4 3 9 1.6 CCNC(=O)N1CCC(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)CC1 10.1021/jm300323t
44436079 145604 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human adenosine A3 receptor after 15 to 30 minsAntagonist activity at human adenosine A3 receptor after 15 to 30 mins
ChEMBL 521 5 4 9 0.4 CNC(=O)[C@]12CN[C@H]([C@@H]1O)[C@H](n1cnc3c(NCc4cccc(I)c4)ncnc31)O2 10.1016/j.bmc.2007.05.056
CHEMBL391483 145604 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human adenosine A3 receptor after 15 to 30 minsAntagonist activity at human adenosine A3 receptor after 15 to 30 mins
ChEMBL 521 5 4 9 0.4 CNC(=O)[C@]12CN[C@H]([C@@H]1O)[C@H](n1cnc3c(NCc4cccc(I)c4)ncnc31)O2 10.1016/j.bmc.2007.05.056
60154739 77016 None 0 Human Functional pIC50 = 7.9 7.9 177 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 528 5 3 9 3.1 Cc1ccc(CNC(=O)N2CCC(NC(=O)Nc3nc4nn(C)cc4c4nc(-c5ccco5)nn34)CC2)cc1 10.1021/jm300323t
CHEMBL2071048 77016 None 0 Human Functional pIC50 = 7.9 7.9 177 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 528 5 3 9 3.1 Cc1ccc(CNC(=O)N2CCC(NC(=O)Nc3nc4nn(C)cc4c4nc(-c5ccco5)nn34)CC2)cc1 10.1021/jm300323t
11151115 69414 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation
ChEMBL 312 1 1 5 2.0 O=c1[nH]c2ccccc2n2c(=O)c(-c3ccc(Cl)cc3)nn12 10.1021/jm0708376
CHEMBL193141 69414 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation
ChEMBL 312 1 1 5 2.0 O=c1[nH]c2ccccc2n2c(=O)c(-c3ccc(Cl)cc3)nn12 10.1021/jm0708376
136086901 63634 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 355 5 1 6 1.8 C=CCN1C(=O)N2CC(CC)N=C2c2[nH]c(-c3cc(OC)nn3C)nc21 10.1021/jm2004738
CHEMBL1800782 63634 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 355 5 1 6 1.8 C=CCN1C(=O)N2CC(CC)N=C2c2[nH]c(-c3cc(OC)nn3C)nc21 10.1021/jm2004738
134138939 147495 None 0 Human Functional pIC50 = 7.9 7.9 -4 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 410 6 2 6 5.0 COc1cc(Nc2nc(Cl)cc3c(-c4ccccc4)n[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
CHEMBL3929812 147495 None 0 Human Functional pIC50 = 7.9 7.9 -4 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 410 6 2 6 5.0 COc1cc(Nc2nc(Cl)cc3c(-c4ccccc4)n[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
168271362 190668 None 0 Human Functional pIC50 = 7.9 7.9 -4 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 372 6 3 6 3.8 Cn1nc(NC(=O)CNc2ccccc2)c2cc(Nc3ccccc3)ncc21 10.1021/acs.jmedchem.2c01123
CHEMBL5180010 190668 None 0 Human Functional pIC50 = 7.9 7.9 -4 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 372 6 3 6 3.8 Cn1nc(NC(=O)CNc2ccccc2)c2cc(Nc3ccccc3)ncc21 10.1021/acs.jmedchem.2c01123
10791347 165259 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human A3 receptorInhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human A3 receptor
ChEMBL 494 7 2 9 4.6 COc1ccc(NC(=O)Nc2nc3nn(CCc4ccccc4)cc3c3nc(-c4ccco4)nn23)cc1 10.1021/jm991114s
CHEMBL422820 165259 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human A3 receptorInhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human A3 receptor
ChEMBL 494 7 2 9 4.6 COc1ccc(NC(=O)Nc2nc3nn(CCc4ccccc4)cc3c3nc(-c4ccco4)nn23)cc1 10.1021/jm991114s
57388054 75510 None 0 Human Functional pIC50 = 6.9 6.9 -1 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 607 12 5 10 3.5 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccccc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
CHEMBL2042305 75510 None 0 Human Functional pIC50 = 6.9 6.9 -1 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 607 12 5 10 3.5 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccccc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
60154835 77228 None 0 Human Functional pIC50 = 6.9 6.9 17 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 507 3 2 10 1.2 CN1CCN(C(=O)N2CCC(NC(=O)Nc3nc4nn(C)cc4c4nc(-c5ccco5)nn34)CC2)CC1 10.1021/jm300323t
CHEMBL2071051 77228 None 0 Human Functional pIC50 = 6.9 6.9 17 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 507 3 2 10 1.2 CN1CCN(C(=O)N2CCC(NC(=O)Nc3nc4nn(C)cc4c4nc(-c5ccco5)nn34)CC2)CC1 10.1021/jm300323t
CHEMBL2079181 77228 None 0 Human Functional pIC50 = 6.9 6.9 17 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 507 3 2 10 1.2 CN1CCN(C(=O)N2CCC(NC(=O)Nc3nc4nn(C)cc4c4nc(-c5ccco5)nn34)CC2)CC1 10.1021/jm300323t
57384289 75508 None 0 Human Functional pIC50 = 6.9 6.9 -18 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 630 13 6 13 2.5 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(NC(=O)CCCC[C@H]5CCSS5)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
CHEMBL2042303 75508 None 0 Human Functional pIC50 = 6.9 6.9 -18 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 630 13 6 13 2.5 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(NC(=O)CCCC[C@H]5CCSS5)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
60155796 76994 None 0 Human Functional pIC50 = 6.9 6.9 16 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 471 5 2 9 3.1 Cn1cc2c(nc(NC(=O)NC3CCN(Cc4ccccc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2070886 76994 None 0 Human Functional pIC50 = 6.9 6.9 16 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 471 5 2 9 3.1 Cn1cc2c(nc(NC(=O)NC3CCN(Cc4ccccc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
24749597 88821 None 1 Human Functional pIC50 = 6.9 6.9 - 1
Activity at human adenosine A3 receptor expressed in CHO cells assessed as antagonism of Cl-IB-MECA-inhibited cAMP productionActivity at human adenosine A3 receptor expressed in CHO cells assessed as antagonism of Cl-IB-MECA-inhibited cAMP production
ChEMBL 295 3 2 4 2.2 COc1ccc(NC(=O)c2nc(=O)[nH]c3ccccc23)cc1 10.1021/jm070852a
CHEMBL236373 88821 None 1 Human Functional pIC50 = 6.9 6.9 - 1
Activity at human adenosine A3 receptor expressed in CHO cells assessed as antagonism of Cl-IB-MECA-inhibited cAMP productionActivity at human adenosine A3 receptor expressed in CHO cells assessed as antagonism of Cl-IB-MECA-inhibited cAMP production
ChEMBL 295 3 2 4 2.2 COc1ccc(NC(=O)c2nc(=O)[nH]c3ccccc23)cc1 10.1021/jm070852a
71602066 86947 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Inhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECAInhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECA
ChEMBL 359 4 1 6 3.4 COc1ccc(-n2cc3nc(C)nc(NC(=O)c4ccccc4)c3n2)cc1 10.1021/jm400068e
CHEMBL2322903 86947 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Inhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECAInhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECA
ChEMBL 359 4 1 6 3.4 COc1ccc(-n2cc3nc(C)nc(NC(=O)c4ccccc4)c3n2)cc1 10.1021/jm400068e
127036423 137641 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 397 4 1 6 4.8 O=C(Nc1nc(-c2ccccc2)nc2cn(-c3ccccc3)nc12)c1cccs1 10.1016/j.ejmech.2015.11.015
CHEMBL3754500 137641 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 397 4 1 6 4.8 O=C(Nc1nc(-c2ccccc2)nc2cn(-c3ccccc3)nc12)c1cccs1 10.1016/j.ejmech.2015.11.015
10791347 165259 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptorInhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor
ChEMBL 494 7 2 9 4.6 COc1ccc(NC(=O)Nc2nc3nn(CCc4ccccc4)cc3c3nc(-c4ccco4)nn23)cc1 10.1021/jm001047y
CHEMBL422820 165259 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptorInhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor
ChEMBL 494 7 2 9 4.6 COc1ccc(NC(=O)Nc2nc3nn(CCc4ccccc4)cc3c3nc(-c4ccco4)nn23)cc1 10.1021/jm001047y
25230881 6179 None 0 Human Functional pIC50 = 6.9 6.9 -8 4
Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.
ChEMBL 395 6 1 8 4.1 CN(C)c1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1 nan
CHEMBL1081160 6179 None 0 Human Functional pIC50 = 6.9 6.9 -8 4
Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.
ChEMBL 395 6 1 8 4.1 CN(C)c1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1 nan
52946211 17598 None 0 Human Functional pIC50 = 4.9 4.9 -3981 2
Antagonist activity at adenosine A3 receptor by cAMP assayAntagonist activity at adenosine A3 receptor by cAMP assay
ChEMBL 465 6 2 7 5.6 COc1ccc(Nc2c(-c3ccc4nccnc4c3)c(C)nn2-c2ccccc2C)c(C(=O)O)c1 10.1016/j.bmcl.2010.07.095
CHEMBL1258170 17598 None 0 Human Functional pIC50 = 4.9 4.9 -3981 2
Antagonist activity at adenosine A3 receptor by cAMP assayAntagonist activity at adenosine A3 receptor by cAMP assay
ChEMBL 465 6 2 7 5.6 COc1ccc(Nc2c(-c3ccc4nccnc4c3)c(C)nn2-c2ccccc2C)c(C(=O)O)c1 10.1016/j.bmcl.2010.07.095
135511822 112738 None 6 Human Functional pIC50 = 6.9 6.9 - 1
Activity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation countingActivity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation counting
ChEMBL 251 1 1 5 2.8 Oc1nc2ccccc2c2cc(-c3ccco3)nn12 10.1016/j.bmc.2012.10.031
CHEMBL330394 112738 None 6 Human Functional pIC50 = 6.9 6.9 - 1
Activity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation countingActivity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation counting
ChEMBL 251 1 1 5 2.8 Oc1nc2ccccc2c2cc(-c3ccco3)nn12 10.1016/j.bmc.2012.10.031
57384543 75513 None 0 Human Functional pIC50 = 5.9 5.9 -3 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 838 14 6 11 7.3 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)cc(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
CHEMBL2042308 75513 None 0 Human Functional pIC50 = 5.9 5.9 -3 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 838 14 6 11 7.3 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)cc(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
136025990 63633 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 341 4 1 6 1.4 C=CCN1C(=O)N2CC(C)N=C2c2[nH]c(-c3cc(OC)nn3C)nc21 10.1021/jm2004738
CHEMBL1800781 63633 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 341 4 1 6 1.4 C=CCN1C(=O)N2CC(C)N=C2c2[nH]c(-c3cc(OC)nn3C)nc21 10.1021/jm2004738
136025881 63654 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 342 5 1 6 2.0 C=CCN1C(=O)N2CC(CC)N=C2c2[nH]c(-c3cc(OC)no3)nc21 10.1021/jm2004738
CHEMBL1800862 63654 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 342 5 1 6 2.0 C=CCN1C(=O)N2CC(CC)N=C2c2[nH]c(-c3cc(OC)no3)nc21 10.1021/jm2004738
9910158 32458 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 10.8-21.5Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 10.8-21.5
ChEMBL 422 4 2 8 4.1 CCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1021/jm001047y
CHEMBL141154 32458 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 10.8-21.5Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 10.8-21.5
ChEMBL 422 4 2 8 4.1 CCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1021/jm001047y
24749707 90845 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Activity at human adenosine A3 receptor expressed in CHO cells assessed as antagonism of Cl-IB-MECA-inhibited cAMP productionActivity at human adenosine A3 receptor expressed in CHO cells assessed as antagonism of Cl-IB-MECA-inhibited cAMP production
ChEMBL 306 3 2 4 2.8 CC(=O)Nc1nc(C(=O)Nc2ccccc2)c2ccccc2n1 10.1021/jm070852a
CHEMBL239193 90845 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Activity at human adenosine A3 receptor expressed in CHO cells assessed as antagonism of Cl-IB-MECA-inhibited cAMP productionActivity at human adenosine A3 receptor expressed in CHO cells assessed as antagonism of Cl-IB-MECA-inhibited cAMP production
ChEMBL 306 3 2 4 2.8 CC(=O)Nc1nc(C(=O)Nc2ccccc2)c2ccccc2n1 10.1021/jm070852a
57384544 75514 None 0 Human Functional pIC50 = 5.9 5.9 -1 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 854 14 7 12 7.0 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)c(O)c(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
CHEMBL2042309 75514 None 0 Human Functional pIC50 = 5.9 5.9 -1 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 854 14 7 12 7.0 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)c(O)c(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
57387824 75504 None 0 Human Functional pIC50 = 6.9 6.9 -10 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 442 7 6 11 -0.6 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(N)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
CHEMBL2042299 75504 None 0 Human Functional pIC50 = 6.9 6.9 -10 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 442 7 6 11 -0.6 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(N)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
44570157 189978 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay
ChEMBL 399 3 1 5 4.9 O=C(Nc1nc2ccccc2c2cn(-c3ccc(Cl)cc3)nc12)c1ccncc1 10.1016/j.bmc.2008.10.018
CHEMBL516851 189978 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay
ChEMBL 399 3 1 5 4.9 O=C(Nc1nc2ccccc2c2cn(-c3ccc(Cl)cc3)nc12)c1ccncc1 10.1016/j.bmc.2008.10.018
11569026 83137 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 471 5 2 6 5.2 Cc1ccc(-c2nc(NC(=O)Nc3ccc(F)cc3)c3nnn(Cc4ccccc4F)c3n2)cc1 10.1021/jm300087j
CHEMBL2181977 83137 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 471 5 2 6 5.2 Cc1ccc(-c2nc(NC(=O)Nc3ccc(F)cc3)c3nnn(Cc4ccccc4F)c3n2)cc1 10.1021/jm300087j
57388056 75512 None 0 Human Functional pIC50 = 6.8 6.8 -4 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 685 12 5 10 4.2 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(Br)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
CHEMBL2042307 75512 None 0 Human Functional pIC50 = 6.8 6.8 -4 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 685 12 5 10 4.2 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(Br)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
102213 207058 None 55 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human adenosine A3 receptor after 15 to 30 minsAntagonist activity at human adenosine A3 receptor after 15 to 30 mins
ChEMBL 281 3 3 9 -1.3 CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(N)ncnc21 10.1016/j.bmc.2007.05.056
CHEMBL73237 207058 None 55 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human adenosine A3 receptor after 15 to 30 minsAntagonist activity at human adenosine A3 receptor after 15 to 30 mins
ChEMBL 281 3 3 9 -1.3 CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(N)ncnc21 10.1016/j.bmc.2007.05.056
60156108 77014 None 0 Human Functional pIC50 = 7.8 7.8 69 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 532 5 3 9 2.9 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCc4ccc(F)cc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2071046 77014 None 0 Human Functional pIC50 = 7.8 7.8 69 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 532 5 3 9 2.9 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCc4ccc(F)cc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
9910158 32458 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human Adenosine A3 receptorInhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human Adenosine A3 receptor
ChEMBL 422 4 2 8 4.1 CCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1021/jm991114s
CHEMBL141154 32458 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human Adenosine A3 receptorInhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human Adenosine A3 receptor
ChEMBL 422 4 2 8 4.1 CCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1021/jm991114s
377 2758 None 42 Human Functional pIC50 = 7.8 7.8 -3 10
Agonist activity at wild type human A3 receptor L90'3.32A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor L90'3.32A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
425 2758 None 42 Human Functional pIC50 = 7.8 7.8 -3 10
Agonist activity at wild type human A3 receptor L90'3.32A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor L90'3.32A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
448222 2758 None 42 Human Functional pIC50 = 7.8 7.8 -3 10
Agonist activity at wild type human A3 receptor L90'3.32A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor L90'3.32A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
CHEMBL464859 2758 None 42 Human Functional pIC50 = 7.8 7.8 -3 10
Agonist activity at wild type human A3 receptor L90'3.32A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor L90'3.32A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
136068716 63638 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 391 4 1 6 2.4 COc1cc(-c2nc3c([nH]2)C2=N[C@H](C)CN2C(=O)N3Cc2ccccc2)n(C)n1 10.1021/jm2004738
CHEMBL1800786 63638 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 391 4 1 6 2.4 COc1cc(-c2nc3c([nH]2)C2=N[C@H](C)CN2C(=O)N3Cc2ccccc2)n(C)n1 10.1021/jm2004738
44436076 88584 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human adenosine A3 receptor after 15 to 30 minsAntagonist activity at human adenosine A3 receptor after 15 to 30 mins
ChEMBL 495 5 3 9 1.1 OC[C@]12CO[C@H]([C@@H]1O)[C@H](n1cnc3c(NCc4cccc(I)c4)ncnc31)O2 10.1016/j.bmc.2007.05.056
CHEMBL235317 88584 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human adenosine A3 receptor after 15 to 30 minsAntagonist activity at human adenosine A3 receptor after 15 to 30 mins
ChEMBL 495 5 3 9 1.1 OC[C@]12CO[C@H]([C@@H]1O)[C@H](n1cnc3c(NCc4cccc(I)c4)ncnc31)O2 10.1016/j.bmc.2007.05.056
139248515 166948 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as reduction in Cl-IB-MECA-induced inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 10 mins followed by Cl-IB-MECA addition measured after 30 mins by liquid scintillation counting methodAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as reduction in Cl-IB-MECA-induced inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 10 mins followed by Cl-IB-MECA addition measured after 30 mins by liquid scintillation counting method
ChEMBL 331 7 1 5 3.9 CC[C@H](C)Oc1cc(NC(C)=O)nc(SCc2ccccc2)n1 10.1039/C7MD00375G
CHEMBL4285494 166948 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as reduction in Cl-IB-MECA-induced inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 10 mins followed by Cl-IB-MECA addition measured after 30 mins by liquid scintillation counting methodAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as reduction in Cl-IB-MECA-induced inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 10 mins followed by Cl-IB-MECA addition measured after 30 mins by liquid scintillation counting method
ChEMBL 331 7 1 5 3.9 CC[C@H](C)Oc1cc(NC(C)=O)nc(SCc2ccccc2)n1 10.1039/C7MD00375G
102143332 113125 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Agonist activity at human recombinant A3AR expressed in CHO cells assessed as inhibition of forskolin-induced stimulation of cAMP productionAgonist activity at human recombinant A3AR expressed in CHO cells assessed as inhibition of forskolin-induced stimulation of cAMP production
ChEMBL 421 6 4 10 0.7 COc1ccc(Cl)cc1CNc1ncnc2c1ncn2[C@@H]1OC[C@@](O)(CO)[C@H]1O 10.1016/j.bmc.2014.05.036
CHEMBL3311508 113125 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Agonist activity at human recombinant A3AR expressed in CHO cells assessed as inhibition of forskolin-induced stimulation of cAMP productionAgonist activity at human recombinant A3AR expressed in CHO cells assessed as inhibition of forskolin-induced stimulation of cAMP production
ChEMBL 421 6 4 10 0.7 COc1ccc(Cl)cc1CNc1ncnc2c1ncn2[C@@H]1OC[C@@](O)(CO)[C@H]1O 10.1016/j.bmc.2014.05.036
60155897 77002 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 472 5 2 10 2.5 Cn1cc2c(nc(NC(=O)NC3CCN(Cc4ccncc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2070894 77002 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 472 5 2 10 2.5 Cn1cc2c(nc(NC(=O)NC3CCN(Cc4ccncc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
52937930 61291 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 minsAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 mins
ChEMBL 386 4 2 5 4.0 COc1ccccc1NC(=O)Nc1nn(-c2ccccc2)c(=O)c2ccccc12 10.1021/jm101328n
CHEMBL1766354 61291 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 minsAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 mins
ChEMBL 386 4 2 5 4.0 COc1ccccc1NC(=O)Nc1nn(-c2ccccc2)c(=O)c2ccccc12 10.1021/jm101328n
136086903 63639 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 391 4 1 6 2.4 COc1cc(-c2nc3c([nH]2)C2=N[C@@H](C)CN2C(=O)N3Cc2ccccc2)n(C)n1 10.1021/jm2004738
CHEMBL1800787 63639 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 391 4 1 6 2.4 COc1cc(-c2nc3c([nH]2)C2=N[C@@H](C)CN2C(=O)N3Cc2ccccc2)n(C)n1 10.1021/jm2004738
44436078 145332 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human adenosine A3 receptor after 15 to 30 minsAntagonist activity at human adenosine A3 receptor after 15 to 30 mins
ChEMBL 305 2 4 9 -2.2 CNC(=O)[C@]12CN[C@H]([C@@H]1O)[C@H](n1cnc3c(N)ncnc31)O2 10.1016/j.bmc.2007.05.056
CHEMBL391279 145332 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human adenosine A3 receptor after 15 to 30 minsAntagonist activity at human adenosine A3 receptor after 15 to 30 mins
ChEMBL 305 2 4 9 -2.2 CNC(=O)[C@]12CN[C@H]([C@@H]1O)[C@H](n1cnc3c(N)ncnc31)O2 10.1016/j.bmc.2007.05.056
57387822 75517 None 0 Human Functional pIC50 = 5.8 5.8 1 3
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 840 13 7 12 6.6 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)c(O)c(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
CHEMBL2042312 75517 None 0 Human Functional pIC50 = 5.8 5.8 1 3
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 840 13 7 12 6.6 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)c(O)c(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
11233411 133692 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 350 5 0 6 2.6 CCCn1c(=O)c2c(nc3n2CC(CC)=C3)n(Cc2ccccc2)c1=O 10.1021/jm300087j
CHEMBL371404 133692 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 350 5 0 6 2.6 CCCn1c(=O)c2c(nc3n2CC(CC)=C3)n(Cc2ccccc2)c1=O 10.1021/jm300087j
52937929 61290 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 minsAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 mins
ChEMBL 386 4 2 5 4.0 COc1cccc(NC(=O)Nc2nn(-c3ccccc3)c(=O)c3ccccc23)c1 10.1021/jm101328n
CHEMBL1766353 61290 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 minsAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 mins
ChEMBL 386 4 2 5 4.0 COc1cccc(NC(=O)Nc2nn(-c3ccccc3)c(=O)c3ccccc23)c1 10.1021/jm101328n
60155896 77001 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 472 5 2 10 2.5 Cn1cc2c(nc(NC(=O)NC3CCN(Cc4cccnc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2070893 77001 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 472 5 2 10 2.5 Cn1cc2c(nc(NC(=O)NC3CCN(Cc4cccnc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
71528098 175048 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonist activity at human adenosine receptor A3 expressed in CHO cells assessed as suppression of NECA-induced decrease of cAMP accumulation by Glo-sensor cAMP assayAntagonist activity at human adenosine receptor A3 expressed in CHO cells assessed as suppression of NECA-induced decrease of cAMP accumulation by Glo-sensor cAMP assay
ChEMBL 280 3 0 3 4.2 CCOc1cccc2cc(-c3ccc(C)cc3)c(=O)oc12 10.1021/acs.jmedchem.9b01572
CHEMBL4565447 175048 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonist activity at human adenosine receptor A3 expressed in CHO cells assessed as suppression of NECA-induced decrease of cAMP accumulation by Glo-sensor cAMP assayAntagonist activity at human adenosine receptor A3 expressed in CHO cells assessed as suppression of NECA-induced decrease of cAMP accumulation by Glo-sensor cAMP assay
ChEMBL 280 3 0 3 4.2 CCOc1cccc2cc(-c3ccc(C)cc3)c(=O)oc12 10.1021/acs.jmedchem.9b01572
1047282 9935 None 10 Human Functional pIC50 = 6.7 6.7 - 1
Inhibition of [35S]GTP-gamma-S, binding stimulated by 20 uM 5''-N-ethyluronamidoadenosine (NECA) in membranes of HEK293 cells expressing human Adenosine A3 receptorInhibition of [35S]GTP-gamma-S, binding stimulated by 20 uM 5''-N-ethyluronamidoadenosine (NECA) in membranes of HEK293 cells expressing human Adenosine A3 receptor
ChEMBL 416 6 1 6 3.6 CCOC(=O)c1c(NC(=O)Cc2ccccc2)sc2c1CCN(C(=O)OCC)C2 10.1016/s0960-894x(99)00583-1
CHEMBL114535 9935 None 10 Human Functional pIC50 = 6.7 6.7 - 1
Inhibition of [35S]GTP-gamma-S, binding stimulated by 20 uM 5''-N-ethyluronamidoadenosine (NECA) in membranes of HEK293 cells expressing human Adenosine A3 receptorInhibition of [35S]GTP-gamma-S, binding stimulated by 20 uM 5''-N-ethyluronamidoadenosine (NECA) in membranes of HEK293 cells expressing human Adenosine A3 receptor
ChEMBL 416 6 1 6 3.6 CCOC(=O)c1c(NC(=O)Cc2ccccc2)sc2c1CCN(C(=O)OCC)C2 10.1016/s0960-894x(99)00583-1
9904456 99202 None 0 Human Functional pIC50 = 6.7 6.7 -30 2
Antagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECAAntagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECA
ChEMBL 301 2 1 9 1.6 CSc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1C 10.1021/jm021023m
CHEMBL281129 99202 None 0 Human Functional pIC50 = 6.7 6.7 -30 2
Antagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECAAntagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECA
ChEMBL 301 2 1 9 1.6 CSc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1C 10.1021/jm021023m
71601787 86962 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human adenosine A3A receptor expressed in CHO cells assessed as inhibition of cAMP accumulationAntagonist activity at human adenosine A3A receptor expressed in CHO cells assessed as inhibition of cAMP accumulation
ChEMBL 359 4 1 6 3.4 COc1ccc(C(=O)Nc2nc(C)nc3cn(-c4ccccc4)nc23)cc1 10.1016/j.ejmech.2021.113907
CHEMBL2322924 86962 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human adenosine A3A receptor expressed in CHO cells assessed as inhibition of cAMP accumulationAntagonist activity at human adenosine A3A receptor expressed in CHO cells assessed as inhibition of cAMP accumulation
ChEMBL 359 4 1 6 3.4 COc1ccc(C(=O)Nc2nc(C)nc3cn(-c4ccccc4)nc23)cc1 10.1016/j.ejmech.2021.113907
71601786 86961 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Inhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECAInhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECA
ChEMBL 329 3 1 5 3.4 Cc1nc(NC(=O)c2ccccc2)c2nn(-c3ccccc3)cc2n1 10.1021/jm400068e
CHEMBL2322923 86961 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Inhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECAInhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECA
ChEMBL 329 3 1 5 3.4 Cc1nc(NC(=O)c2ccccc2)c2nn(-c3ccccc3)cc2n1 10.1021/jm400068e
10505816 30362 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human A3 receptorInhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human A3 receptor
ChEMBL 508 8 2 9 5.0 COc1ccc(NC(=O)Nc2nc3nn(CCCc4ccccc4)cc3c3nc(-c4ccco4)nn23)cc1 10.1021/jm991114s
CHEMBL139182 30362 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human A3 receptorInhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human A3 receptor
ChEMBL 508 8 2 9 5.0 COc1ccc(NC(=O)Nc2nc3nn(CCCc4ccccc4)cc3c3nc(-c4ccco4)nn23)cc1 10.1021/jm991114s
9803992 110487 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 130-279Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 130-279
ChEMBL 454 4 3 10 2.2 Cn1cc2c(nc(NC(=O)Nc3ccc(S(=O)(=O)O)cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
CHEMBL324512 110487 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 130-279Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 130-279
ChEMBL 454 4 3 10 2.2 Cn1cc2c(nc(NC(=O)Nc3ccc(S(=O)(=O)O)cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
137641603 158322 None 0 Human Functional pIC50 = 5.7 5.7 -3 2
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-stimulated adenylyl cyclase in presence of [alpha-31P]ATPAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-stimulated adenylyl cyclase in presence of [alpha-31P]ATP
ChEMBL 447 5 3 10 2.0 Cc1cc(C)n(C[C@H]2O[C@@H](n3cnc4c(NC5CCCC5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b01399
CHEMBL4088238 158322 None 0 Human Functional pIC50 = 5.7 5.7 -3 2
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-stimulated adenylyl cyclase in presence of [alpha-31P]ATPAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-stimulated adenylyl cyclase in presence of [alpha-31P]ATP
ChEMBL 447 5 3 10 2.0 Cc1cc(C)n(C[C@H]2O[C@@H](n3cnc4c(NC5CCCC5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b01399
137651531 157562 None 0 Human Functional pIC50 = 5.7 5.7 -3 2
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-stimulated adenylyl cyclase in presence of [alpha-31P]ATPAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-stimulated adenylyl cyclase in presence of [alpha-31P]ATP
ChEMBL 517 6 3 10 3.6 Cc1cc(C)cc(-c2nc(NC3CCCC3)c3ncn([C@@H]4O[C@H](Cn5nc(C)cc5C)[C@@H](O)[C@H]4O)c3n2)c1 10.1021/acs.jmedchem.7b01399
CHEMBL4079314 157562 None 0 Human Functional pIC50 = 5.7 5.7 -3 2
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-stimulated adenylyl cyclase in presence of [alpha-31P]ATPAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-stimulated adenylyl cyclase in presence of [alpha-31P]ATP
ChEMBL 517 6 3 10 3.6 Cc1cc(C)cc(-c2nc(NC3CCCC3)c3ncn([C@@H]4O[C@H](Cn5nc(C)cc5C)[C@@H](O)[C@H]4O)c3n2)c1 10.1021/acs.jmedchem.7b01399
9929470 110536 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in membranes of CHO cells expressing human Adenosine A3 receptorInhibition of IB-MECA agonist-mediated cAMP production in membranes of CHO cells expressing human Adenosine A3 receptor
ChEMBL 374 3 2 8 2.9 Cn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
CHEMBL324735 110536 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in membranes of CHO cells expressing human Adenosine A3 receptorInhibition of IB-MECA agonist-mediated cAMP production in membranes of CHO cells expressing human Adenosine A3 receptor
ChEMBL 374 3 2 8 2.9 Cn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
10296638 36779 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 1.1-3.8Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 1.1-3.8
ChEMBL 434 4 2 7 4.8 COc1ccc(NC(=O)Nc2nc3ccc(Cl)cc3c3nc(-c4ccco4)nn23)cc1 10.1021/jm001047y
CHEMBL144979 36779 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 1.1-3.8Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 1.1-3.8
ChEMBL 434 4 2 7 4.8 COc1ccc(NC(=O)Nc2nc3ccc(Cl)cc3c3nc(-c4ccco4)nn23)cc1 10.1021/jm001047y
123683 3121 None 46 Human Functional pIC50 = 8.7 8.7 67 5
Agonist activity at wild type human A3 receptor L90'3.32A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor L90'3.32A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
422 3121 None 46 Human Functional pIC50 = 8.7 8.7 67 5
Agonist activity at wild type human A3 receptor L90'3.32A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor L90'3.32A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
CHEMBL119709 3121 None 46 Human Functional pIC50 = 8.7 8.7 67 5
Agonist activity at wild type human A3 receptor L90'3.32A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor L90'3.32A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
DB05511 3121 None 46 Human Functional pIC50 = 8.7 8.7 67 5
Agonist activity at wild type human A3 receptor L90'3.32A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor L90'3.32A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
3035850 951 None 50 Human Functional pIC50 = 8.7 8.7 -14 2
Inhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptorInhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptor
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/jm0408161
3035850.0 951 None 50 Human Functional pIC50 = 8.7 8.7 -14 2
Inhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptorInhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptor
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/jm0408161
457 951 None 50 Human Functional pIC50 = 8.7 8.7 -14 2
Inhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptorInhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptor
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/jm0408161
CHEMBL431733 951 None 50 Human Functional pIC50 = 8.7 8.7 -14 2
Inhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptorInhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptor
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/jm0408161
DB12885 951 None 50 Human Functional pIC50 = 8.7 8.7 -14 2
Inhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptorInhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptor
ChEMBL 544 5 4 9 1.1 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I 10.1021/jm0408161
127026257 138329 None 0 Human Functional pIC50 = 8.6 8.6 19 3
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 392 5 5 10 -1.1 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4O)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.5b01402
CHEMBL3770310 138329 None 0 Human Functional pIC50 = 8.6 8.6 19 3
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 392 5 5 10 -1.1 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4O)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.5b01402
46237929 8958 None 0 Human Functional pIC50 = 8.6 8.6 138 2
Antagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry
ChEMBL 359 4 1 6 3.3 COc1ccc(C(=O)Nc2nc(-c3ccccc3)nc3nn(C)cc23)cc1 10.1021/jm901785w
CHEMBL1098108 8958 None 0 Human Functional pIC50 = 8.6 8.6 138 2
Antagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry
ChEMBL 359 4 1 6 3.3 COc1ccc(C(=O)Nc2nc(-c3ccccc3)nc3nn(C)cc23)cc1 10.1021/jm901785w
10431614 58148 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in membranes of CHO cells expressing human Adenosine A3 receptor; range 1.2-4.9Inhibition of IB-MECA agonist-mediated cAMP production in membranes of CHO cells expressing human Adenosine A3 receptor; range 1.2-4.9
ChEMBL 408 3 2 8 3.6 Cn1cc2c(nc(NC(=O)Nc3ccc(Cl)cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
CHEMBL167753 58148 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in membranes of CHO cells expressing human Adenosine A3 receptor; range 1.2-4.9Inhibition of IB-MECA agonist-mediated cAMP production in membranes of CHO cells expressing human Adenosine A3 receptor; range 1.2-4.9
ChEMBL 408 3 2 8 3.6 Cn1cc2c(nc(NC(=O)Nc3ccc(Cl)cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
10225178 32945 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptorInhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor
ChEMBL 438 3 2 6 5.5 O=C(Nc1cccc(Cl)c1)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12 10.1021/jm001047y
CHEMBL141550 32945 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptorInhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor
ChEMBL 438 3 2 6 5.5 O=C(Nc1cccc(Cl)c1)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12 10.1021/jm001047y
45483966 201297 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated 45 mins before forskolin challenge measured after 15 mins by radioimmunoassay relative to NECAAgonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated 45 mins before forskolin challenge measured after 15 mins by radioimmunoassay relative to NECA
ChEMBL 792 15 8 12 1.2 CNC(=O)[C@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(Cl)c4)nc(C#CCCC(=O)NCCNC(=O)CCCC[C@H]4SC[C@H]5NC(=O)N[C@H]54)nc31)[C@H](O)[C@@H]2O 10.1021/jm900426g
CHEMBL583747 201297 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated 45 mins before forskolin challenge measured after 15 mins by radioimmunoassay relative to NECAAgonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated 45 mins before forskolin challenge measured after 15 mins by radioimmunoassay relative to NECA
ChEMBL 792 15 8 12 1.2 CNC(=O)[C@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(Cl)c4)nc(C#CCCC(=O)NCCNC(=O)CCCC[C@H]4SC[C@H]5NC(=O)N[C@H]54)nc31)[C@H](O)[C@@H]2O 10.1021/jm900426g
24768449 155363 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as reversal of NECA-mediated inhibition of forskolin-induced cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as reversal of NECA-mediated inhibition of forskolin-induced cAMP accumulation
ChEMBL 347 8 1 6 3.5 CCCSc1nc(NC(C)=O)cc(OCc2ccc(OC)cc2)n1 10.1021/jm701159t
CHEMBL402848 155363 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as reversal of NECA-mediated inhibition of forskolin-induced cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as reversal of NECA-mediated inhibition of forskolin-induced cAMP accumulation
ChEMBL 347 8 1 6 3.5 CCCSc1nc(NC(C)=O)cc(OCc2ccc(OC)cc2)n1 10.1021/jm701159t
9801343 112487 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 1.7-4.2Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 1.7-4.2
ChEMBL 404 4 2 9 2.9 COc1ccc(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1 10.1021/jm001047y
CHEMBL329791 112487 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 1.7-4.2Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 1.7-4.2
ChEMBL 404 4 2 9 2.9 COc1ccc(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1 10.1021/jm001047y
168281982 191305 None 0 Human Functional pIC50 = 8.6 8.6 1 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 516 10 3 8 4.8 COc1cc(Nc2nc(CNCC3CCN(C)CC3)cc3c(-c4ccccc4)n[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
CHEMBL5189274 191305 None 0 Human Functional pIC50 = 8.6 8.6 1 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 516 10 3 8 4.8 COc1cc(Nc2nc(CNCC3CCN(C)CC3)cc3c(-c4ccccc4)n[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
134141301 147145 None 0 Human Functional pIC50 = 8.6 8.6 1 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 376 6 2 6 4.5 COc1cc(Nc2nc(Cl)cc3c(C(C)C)n[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
CHEMBL3927012 147145 None 0 Human Functional pIC50 = 8.6 8.6 1 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 376 6 2 6 4.5 COc1cc(Nc2nc(Cl)cc3c(C(C)C)n[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
136068601 63640 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 405 5 1 6 2.8 CCC1CN2C(=O)N(Cc3ccccc3)c3nc(-c4cc(OC)nn4C)[nH]c3C2=N1 10.1021/jm2004738
CHEMBL1800788 63640 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 405 5 1 6 2.8 CCC1CN2C(=O)N(Cc3ccccc3)c3nc(-c4cc(OC)nn4C)[nH]c3C2=N1 10.1021/jm2004738
136086904 63655 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 378 4 1 6 2.7 COc1cc(-c2nc3c([nH]2)C2=NC(C)CN2C(=O)N3Cc2ccccc2)on1 10.1021/jm2004738
CHEMBL1800863 63655 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 378 4 1 6 2.7 COc1cc(-c2nc3c([nH]2)C2=NC(C)CN2C(=O)N3Cc2ccccc2)on1 10.1021/jm2004738
CHEMBL5075422 216860 None 4 Human Functional pIC50 = 5.7 5.7 -354 4
Antagonist activity at human recombinant adenosine A3 receptor transfected in HEK293 cells co-transfected with Galpha15/16 assessed as intracellular calcium change incubated for 10 mins by microplate reader methodAntagonist activity at human recombinant adenosine A3 receptor transfected in HEK293 cells co-transfected with Galpha15/16 assessed as intracellular calcium change incubated for 10 mins by microplate reader method
ChEMBL None None None Cn1cc(-c2cnc(N)n3nc(-c4ccco4)nc23)ccc1=O 10.1021/acsmedchemlett.1c00599
25212375 190565 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay
ChEMBL 354 3 1 5 4.4 O=C(Nc1nc2ccccc2c2cn(-c3ccccc3)nc12)c1ccco1 10.1016/j.bmc.2008.10.018
CHEMBL517867 190565 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay
ChEMBL 354 3 1 5 4.4 O=C(Nc1nc2ccccc2c2cn(-c3ccccc3)nc12)c1ccco1 10.1016/j.bmc.2008.10.018
60155715 76992 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 421 5 2 9 2.0 C=CCN1CCC(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)CC1 10.1021/jm300323t
CHEMBL2070883 76992 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 421 5 2 9 2.0 C=CCN1CCC(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)CC1 10.1021/jm300323t
11511703 170697 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity against Cl-IB-MECA inhibited cAMP level in CHO cells transfected with human A3 receptorAntagonist activity against Cl-IB-MECA inhibited cAMP level in CHO cells transfected with human A3 receptor
ChEMBL 501 6 1 7 4.8 COc1ccc(-n2nc3c(NC(=O)C(c4ccccc4)c4ccccc4)nc4ccccc4n3c2=O)cc1 10.1021/jm060373w
CHEMBL445067 170697 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity against Cl-IB-MECA inhibited cAMP level in CHO cells transfected with human A3 receptorAntagonist activity against Cl-IB-MECA inhibited cAMP level in CHO cells transfected with human A3 receptor
ChEMBL 501 6 1 7 4.8 COc1ccc(-n2nc3c(NC(=O)C(c4ccccc4)c4ccccc4)nc4ccccc4n3c2=O)cc1 10.1021/jm060373w
25207803 5687 None 0 Human Functional pIC50 = 7.6 7.6 -10 4
Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.
ChEMBL 381 6 2 8 4.0 CNc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1 nan
CHEMBL1077943 5687 None 0 Human Functional pIC50 = 7.6 7.6 -10 4
Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.
ChEMBL 381 6 2 8 4.0 CNc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1 nan
123683 3121 None 46 Human Functional pIC50 = 7.6 7.6 67 5
Agonist activity at wild type human A3 receptor M177'5.38A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor M177'5.38A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
422 3121 None 46 Human Functional pIC50 = 7.6 7.6 67 5
Agonist activity at wild type human A3 receptor M177'5.38A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor M177'5.38A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
CHEMBL119709 3121 None 46 Human Functional pIC50 = 7.6 7.6 67 5
Agonist activity at wild type human A3 receptor M177'5.38A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor M177'5.38A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
DB05511 3121 None 46 Human Functional pIC50 = 7.6 7.6 67 5
Agonist activity at wild type human A3 receptor M177'5.38A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor M177'5.38A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 510 5 4 9 0.4 CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I 10.1021/acs.jmedchem.9b01164
118733025 118602 None 1 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity against human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-induced inhibition of forskolin-induced cAMP production by scintillation counting methodAntagonist activity against human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-induced inhibition of forskolin-induced cAMP production by scintillation counting method
ChEMBL 243 1 1 4 2.4 Cc1nc2sc(-c3ccccc3)nc2c(=O)[nH]1 10.1016/j.ejmech.2015.04.010
CHEMBL3415022 118602 None 1 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity against human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-induced inhibition of forskolin-induced cAMP production by scintillation counting methodAntagonist activity against human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-induced inhibition of forskolin-induced cAMP production by scintillation counting method
ChEMBL 243 1 1 4 2.4 Cc1nc2sc(-c3ccccc3)nc2c(=O)[nH]1 10.1016/j.ejmech.2015.04.010
57387337 75502 None 0 Human Functional pIC50 = 7.6 7.6 -63 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 326 3 4 9 -1.7 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(F)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
CHEMBL2042297 75502 None 0 Human Functional pIC50 = 7.6 7.6 -63 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 326 3 4 9 -1.7 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(F)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
60156106 76831 None 0 Human Functional pIC50 = 7.6 7.6 75 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 528 6 3 9 2.8 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCCc4ccccc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2069325 76831 None 0 Human Functional pIC50 = 7.6 7.6 75 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 528 6 3 9 2.8 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCCc4ccccc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
136019511 63635 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 355 5 1 6 1.8 C=CCN1C(=O)N2C[C@@H](CC)N=C2c2[nH]c(-c3cc(OC)nn3C)nc21 10.1021/jm2004738
CHEMBL1800783 63635 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 355 5 1 6 1.8 C=CCN1C(=O)N2C[C@@H](CC)N=C2c2[nH]c(-c3cc(OC)nn3C)nc21 10.1021/jm2004738
25230949 6007 None 0 Human Functional pIC50 = 6.6 6.6 -15 4
Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.
ChEMBL 367 5 2 8 3.6 Nc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1 nan
CHEMBL1080241 6007 None 0 Human Functional pIC50 = 6.6 6.6 -15 4
Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.
ChEMBL 367 5 2 8 3.6 Nc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1 nan
24749598 98975 None 1 Human Functional pIC50 = 6.6 6.6 - 1
Activity at human adenosine A3 receptor expressed in CHO cells assessed as antagonism of Cl-IB-MECA-inhibited cAMP productionActivity at human adenosine A3 receptor expressed in CHO cells assessed as antagonism of Cl-IB-MECA-inhibited cAMP production
ChEMBL 265 2 2 3 2.2 O=C(Nc1ccccc1)c1nc(=O)[nH]c2ccccc12 10.1021/jm070852a
CHEMBL279403 98975 None 1 Human Functional pIC50 = 6.6 6.6 - 1
Activity at human adenosine A3 receptor expressed in CHO cells assessed as antagonism of Cl-IB-MECA-inhibited cAMP productionActivity at human adenosine A3 receptor expressed in CHO cells assessed as antagonism of Cl-IB-MECA-inhibited cAMP production
ChEMBL 265 2 2 3 2.2 O=C(Nc1ccccc1)c1nc(=O)[nH]c2ccccc12 10.1021/jm070852a
136026027 63653 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 328 4 1 6 1.7 C=CCN1C(=O)N2CC(C)N=C2c2[nH]c(-c3cc(OC)no3)nc21 10.1021/jm2004738
CHEMBL1800861 63653 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 328 4 1 6 1.7 C=CCN1C(=O)N2CC(C)N=C2c2[nH]c(-c3cc(OC)no3)nc21 10.1021/jm2004738
136068719 63656 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 392 5 1 6 3.1 CCC1CN2C(=O)N(Cc3ccccc3)c3nc(-c4cc(OC)no4)[nH]c3C2=N1 10.1021/jm2004738
CHEMBL1800864 63656 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 392 5 1 6 3.1 CCC1CN2C(=O)N(Cc3ccccc3)c3nc(-c4cc(OC)no4)[nH]c3C2=N1 10.1021/jm2004738
57400353 69820 None 0 Human Functional pIC50 = 6.6 6.6 3 2
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by competition protein binding assay
ChEMBL 432 6 2 9 3.8 CCCn1cc2nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc3c2n1 10.1016/j.bmc.2011.11.037
CHEMBL1935765 69820 None 0 Human Functional pIC50 = 6.6 6.6 3 2
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by competition protein binding assay
ChEMBL 432 6 2 9 3.8 CCCn1cc2nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc3c2n1 10.1016/j.bmc.2011.11.037
2910343 33133 None 15 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human adenosine receptor A3 expressed in CHO cells assessed as suppression of NECA-induced decrease of cAMP accumulation by Glo-sensor cAMP assayAntagonist activity at human adenosine receptor A3 expressed in CHO cells assessed as suppression of NECA-induced decrease of cAMP accumulation by Glo-sensor cAMP assay
ChEMBL 282 3 0 4 3.5 COc1ccc(-c2cc3cccc(OC)c3oc2=O)cc1 10.1021/acs.jmedchem.9b01572
CHEMBL1417172 33133 None 15 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human adenosine receptor A3 expressed in CHO cells assessed as suppression of NECA-induced decrease of cAMP accumulation by Glo-sensor cAMP assayAntagonist activity at human adenosine receptor A3 expressed in CHO cells assessed as suppression of NECA-induced decrease of cAMP accumulation by Glo-sensor cAMP assay
ChEMBL 282 3 0 4 3.5 COc1ccc(-c2cc3cccc(OC)c3oc2=O)cc1 10.1021/acs.jmedchem.9b01572
2848828 9947 None 9 Human Functional pIC50 = 6.6 6.6 - 1
Inhibition of [35S]GTP-gamma-S, binding stimulated by 20 uM 5''-N-ethyluronamidoadenosine (NECA) in membranes of HEK293 cells expressing human Adenosine A3 receptorInhibition of [35S]GTP-gamma-S, binding stimulated by 20 uM 5''-N-ethyluronamidoadenosine (NECA) in membranes of HEK293 cells expressing human Adenosine A3 receptor
ChEMBL 398 6 1 8 4.1 COc1ccc(-c2csc(NC3OC(=O)c4c3ccc(OC)c4OC)n2)cc1 10.1016/s0960-894x(99)00583-1
CHEMBL114643 9947 None 9 Human Functional pIC50 = 6.6 6.6 - 1
Inhibition of [35S]GTP-gamma-S, binding stimulated by 20 uM 5''-N-ethyluronamidoadenosine (NECA) in membranes of HEK293 cells expressing human Adenosine A3 receptorInhibition of [35S]GTP-gamma-S, binding stimulated by 20 uM 5''-N-ethyluronamidoadenosine (NECA) in membranes of HEK293 cells expressing human Adenosine A3 receptor
ChEMBL 398 6 1 8 4.1 COc1ccc(-c2csc(NC3OC(=O)c4c3ccc(OC)c4OC)n2)cc1 10.1016/s0960-894x(99)00583-1
57387825 75505 None 0 Human Functional pIC50 = 6.6 6.6 -6 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 505 7 5 10 0.6 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(Br)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
CHEMBL2042300 75505 None 0 Human Functional pIC50 = 6.6 6.6 -6 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 505 7 5 10 0.6 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(Br)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
127037422 137335 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 421 5 1 6 4.7 COc1ccc(-c2nc(NC(=O)c3ccccc3)c3nn(-c4ccccc4)cc3n2)cc1 10.1016/j.ejmech.2015.11.015
CHEMBL3751909 137335 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 421 5 1 6 4.7 COc1ccc(-c2nc(NC(=O)c3ccccc3)c3nn(-c4ccccc4)cc3n2)cc1 10.1016/j.ejmech.2015.11.015
60156104 77011 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 520 4 3 9 3.3 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NC4CCCCCC4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2071043 77011 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 520 4 3 9 3.3 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NC4CCCCCC4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
44570198 178524 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay
ChEMBL 378 3 1 4 5.1 Cc1cccc(C(=O)Nc2nc3ccccc3c3cn(-c4ccccc4)nc23)c1 10.1016/j.bmc.2008.10.018
CHEMBL465946 178524 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay
ChEMBL 378 3 1 4 5.1 Cc1cccc(C(=O)Nc2nc3ccccc3c3cn(-c4ccccc4)nc23)c1 10.1016/j.bmc.2008.10.018
9955052 119947 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 15-44Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 15-44
ChEMBL 442 3 2 8 4.2 Cn1cc2c(nc(NC(=O)Nc3ccc(Cl)c(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
CHEMBL349019 119947 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 15-44Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 15-44
ChEMBL 442 3 2 8 4.2 Cn1cc2c(nc(NC(=O)Nc3ccc(Cl)c(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
60155712 76989 None 0 Human Functional pIC50 = 6.6 6.6 9 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 381 3 3 9 1.1 Cn1cc2c(nc(NC(=O)NC3CCNCC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2070880 76989 None 0 Human Functional pIC50 = 6.6 6.6 9 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 381 3 3 9 1.1 Cn1cc2c(nc(NC(=O)NC3CCNCC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
135516677 4475 None 8 Human Functional pIC50 = 6.6 6.6 - 1
Activity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation countingActivity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation counting
ChEMBL 267 1 1 5 3.3 Oc1nc2ccccc2c2cc(-c3cccs3)nn12 10.1016/j.bmc.2012.10.031
CHEMBL101818 4475 None 8 Human Functional pIC50 = 6.6 6.6 - 1
Activity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation countingActivity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation counting
ChEMBL 267 1 1 5 3.3 Oc1nc2ccccc2c2cc(-c3cccs3)nn12 10.1016/j.bmc.2012.10.031
127025959 138366 None 0 Human Functional pIC50 = 6.6 6.6 -50 3
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 482 8 4 10 1.1 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.5b01402
CHEMBL3770679 138366 None 0 Human Functional pIC50 = 6.6 6.6 -50 3
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 482 8 4 10 1.1 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.5b01402
44343895 10534 None 1 Human Functional pIC50 = 7.6 7.6 1 2
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 351 4 5 10 -1.2 OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4O)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.5b01402
CHEMBL116903 10534 None 1 Human Functional pIC50 = 7.6 7.6 1 2
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 351 4 5 10 -1.2 OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4O)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.5b01402
136086902 63637 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 391 4 1 6 2.4 COc1cc(-c2nc3c([nH]2)C2=NC(C)CN2C(=O)N3Cc2ccccc2)n(C)n1 10.1021/jm2004738
CHEMBL1800785 63637 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 391 4 1 6 2.4 COc1cc(-c2nc3c([nH]2)C2=NC(C)CN2C(=O)N3Cc2ccccc2)n(C)n1 10.1021/jm2004738
135409562 2184 None 8 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assay
ChEMBL 373 3 1 3 3.3 CCCn1c2nc([nH]c2c2=NCCn2c1=O)c1ccc(cc1)Br 10.1021/jm300087j
5618 2184 None 8 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assay
ChEMBL 373 3 1 3 3.3 CCCn1c2nc([nH]c2c2=NCCn2c1=O)c1ccc(cc1)Br 10.1021/jm300087j
CHEMBL2181965 2184 None 8 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assay
ChEMBL 373 3 1 3 3.3 CCCn1c2nc([nH]c2c2=NCCn2c1=O)c1ccc(cc1)Br 10.1021/jm300087j
52937928 61289 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 minsAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 mins
ChEMBL 386 4 2 5 4.0 COc1ccc(NC(=O)Nc2nn(-c3ccccc3)c(=O)c3ccccc23)cc1 10.1021/jm101328n
CHEMBL1766352 61289 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 minsAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 mins
ChEMBL 386 4 2 5 4.0 COc1ccc(NC(=O)Nc2nn(-c3ccccc3)c(=O)c3ccccc23)cc1 10.1021/jm101328n
11627221 79632 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity against Cl-IB-MECA inhibited cAMP level in CHO cells transfected with human A3 receptorAntagonist activity against Cl-IB-MECA inhibited cAMP level in CHO cells transfected with human A3 receptor
ChEMBL 485 4 0 7 4.5 O=C(c1ccccc1)N(C(=O)c1ccccc1)c1nc2ccccc2n2c(=O)n(-c3ccccc3)nc12 10.1021/jm060373w
CHEMBL211449 79632 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity against Cl-IB-MECA inhibited cAMP level in CHO cells transfected with human A3 receptorAntagonist activity against Cl-IB-MECA inhibited cAMP level in CHO cells transfected with human A3 receptor
ChEMBL 485 4 0 7 4.5 O=C(c1ccccc1)N(C(=O)c1ccccc1)c1nc2ccccc2n2c(=O)n(-c3ccccc3)nc12 10.1021/jm060373w
60156105 77012 None 0 Human Functional pIC50 = 7.5 7.5 38 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 514 5 3 9 2.8 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCc4ccccc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2071044 77012 None 0 Human Functional pIC50 = 7.5 7.5 38 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 514 5 3 9 2.8 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCc4ccccc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
44579714 187091 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at NECA-stimulated human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at NECA-stimulated human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 497 4 3 7 2.6 O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc21 10.1016/j.bmc.2008.08.007
CHEMBL490605 187091 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at NECA-stimulated human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at NECA-stimulated human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 497 4 3 7 2.6 O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc21 10.1016/j.bmc.2008.08.007
54580623 62165 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human adenosine receptor A3 expressed in CHO cells assessed as suppression of NECA-induced decrease of cAMP accumulation by Glo-sensor cAMP assayAntagonist activity at human adenosine receptor A3 expressed in CHO cells assessed as suppression of NECA-induced decrease of cAMP accumulation by Glo-sensor cAMP assay
ChEMBL 296 4 0 4 3.9 CCOc1cccc2cc(-c3ccc(OC)cc3)c(=O)oc12 10.1021/acs.jmedchem.9b01572
CHEMBL1777844 62165 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human adenosine receptor A3 expressed in CHO cells assessed as suppression of NECA-induced decrease of cAMP accumulation by Glo-sensor cAMP assayAntagonist activity at human adenosine receptor A3 expressed in CHO cells assessed as suppression of NECA-induced decrease of cAMP accumulation by Glo-sensor cAMP assay
ChEMBL 296 4 0 4 3.9 CCOc1cccc2cc(-c3ccc(OC)cc3)c(=O)oc12 10.1021/acs.jmedchem.9b01572
10453097 200349 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 2.0-4.3Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 2.0-4.3
ChEMBL 392 3 2 8 3.1 Cn1cc2c(nc(NC(=O)Nc3ccc(F)cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
CHEMBL572765 200349 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 2.0-4.3Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 2.0-4.3
ChEMBL 392 3 2 8 3.1 Cn1cc2c(nc(NC(=O)Nc3ccc(F)cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
168291120 192131 None 0 Human Functional pIC50 = 8.5 8.5 2 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 358 6 4 5 3.8 O=C(CNc1ccccc1)Nc1n[nH]c2cnc(Nc3ccccc3)cc12 10.1021/acs.jmedchem.2c01123
CHEMBL5201810 192131 None 0 Human Functional pIC50 = 8.5 8.5 2 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 358 6 4 5 3.8 O=C(CNc1ccccc1)Nc1n[nH]c2cnc(Nc3ccccc3)cc12 10.1021/acs.jmedchem.2c01123
23657265 88619 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation
ChEMBL 445 4 1 7 3.9 COc1ccc(C(=O)Nc2nc3ccc(Cl)cc3n3c(=O)c(-c4ccccc4)nn23)cc1 10.1021/jm0708376
CHEMBL235513 88619 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation
ChEMBL 445 4 1 7 3.9 COc1ccc(C(=O)Nc2nc3ccc(Cl)cc3n3c(=O)c(-c4ccccc4)nn23)cc1 10.1021/jm0708376
10884265 57426 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 1.8-5.6Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 1.8-5.6
ChEMBL 418 3 2 10 2.6 Cn1cc2c(nc(NC(=O)Nc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
CHEMBL165224 57426 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 1.8-5.6Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 1.8-5.6
ChEMBL 418 3 2 10 2.6 Cn1cc2c(nc(NC(=O)Nc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
377 2758 None 42 Human Functional pIC50 = 8.4 8.4 -3 10
Agonist activity at wild type human A3 receptor M174'5.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor M174'5.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
425 2758 None 42 Human Functional pIC50 = 8.4 8.4 -3 10
Agonist activity at wild type human A3 receptor M174'5.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor M174'5.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
448222 2758 None 42 Human Functional pIC50 = 8.4 8.4 -3 10
Agonist activity at wild type human A3 receptor M174'5.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor M174'5.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
CHEMBL464859 2758 None 42 Human Functional pIC50 = 8.4 8.4 -3 10
Agonist activity at wild type human A3 receptor M174'5.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assayAgonist activity at wild type human A3 receptor M174'5.35A mutant stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by LANCE assay
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/acs.jmedchem.9b01164
168276434 190227 None 0 Human Functional pIC50 = 8.4 8.4 -1 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 367 6 2 7 3.7 COc1cc(Nc2nc(C#N)cc3c(C(C)C)n[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
CHEMBL5173159 190227 None 0 Human Functional pIC50 = 8.4 8.4 -1 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 367 6 2 7 3.7 COc1cc(Nc2nc(C#N)cc3c(C(C)C)n[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
60156005 77009 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 492 4 3 9 2.5 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NC4CCCC4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2071041 77009 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 492 4 3 9 2.5 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NC4CCCC4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
60154837 77201 None 6 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 477 5 2 9 3.4 Cn1cc2c(nc(NC(=O)NC3CCN(CC4CCCCC4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2070885 77201 None 6 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 477 5 2 9 3.4 Cn1cc2c(nc(NC(=O)NC3CCN(CC4CCCCC4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2078778 77201 None 6 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 477 5 2 9 3.4 Cn1cc2c(nc(NC(=O)NC3CCN(CC4CCCCC4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
136086898 63611 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 339 4 1 5 2.1 C=CCN1C(=O)N2CC(CC)N=C2c2[nH]c(-c3cc(C)nn3C)nc21 10.1021/jm2004738
CHEMBL1800736 63611 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 339 4 1 5 2.1 C=CCN1C(=O)N2CC(CC)N=C2c2[nH]c(-c3cc(C)nn3C)nc21 10.1021/jm2004738
60155714 76991 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 423 5 2 9 2.3 CCCN1CCC(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)CC1 10.1021/jm300323t
CHEMBL2070882 76991 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 423 5 2 9 2.3 CCCN1CCC(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)CC1 10.1021/jm300323t
25230952 146640 None 0 Human Functional pIC50 = 6.5 6.5 -4 4
Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.
ChEMBL 458 8 2 9 5.0 O=C(c1cccs1)c1nc(NCc2cccnc2)nc2cc(NCc3cccnc3)sc12 nan
CHEMBL3922797 146640 None 0 Human Functional pIC50 = 6.5 6.5 -4 4
Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.
ChEMBL 458 8 2 9 5.0 O=C(c1cccs1)c1nc(NCc2cccnc2)nc2cc(NCc3cccnc3)sc12 nan
11533636 79945 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity against Cl-IB-MECA inhibited cAMP level in CHO cells transfected with human A3 receptorAntagonist activity against Cl-IB-MECA inhibited cAMP level in CHO cells transfected with human A3 receptor
ChEMBL 515 5 0 8 4.5 COc1ccc(-n2nc3c(N(C(=O)c4ccccc4)C(=O)c4ccccc4)nc4ccccc4n3c2=O)cc1 10.1021/jm060373w
CHEMBL212458 79945 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity against Cl-IB-MECA inhibited cAMP level in CHO cells transfected with human A3 receptorAntagonist activity against Cl-IB-MECA inhibited cAMP level in CHO cells transfected with human A3 receptor
ChEMBL 515 5 0 8 4.5 COc1ccc(-n2nc3c(N(C(=O)c4ccccc4)C(=O)c4ccccc4)nc4ccccc4n3c2=O)cc1 10.1021/jm060373w
155544177 173442 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human adenosine A3A receptorAntagonist activity at human adenosine A3A receptor
ChEMBL 316 1 1 3 3.9 O=c1oc2c(O)cccc2cc1-c1ccc(Br)cc1 10.1016/j.ejmech.2021.113907
CHEMBL4526845 173442 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human adenosine A3A receptorAntagonist activity at human adenosine A3A receptor
ChEMBL 316 1 1 3 3.9 O=c1oc2c(O)cccc2cc1-c1ccc(Br)cc1 10.1016/j.ejmech.2021.113907
155544177 173442 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human adenosine receptor A3 expressed in CHO cells assessed as suppression of NECA-induced decrease of cAMP accumulation by Glo-sensor cAMP assayAntagonist activity at human adenosine receptor A3 expressed in CHO cells assessed as suppression of NECA-induced decrease of cAMP accumulation by Glo-sensor cAMP assay
ChEMBL 316 1 1 3 3.9 O=c1oc2c(O)cccc2cc1-c1ccc(Br)cc1 10.1021/acs.jmedchem.9b01572
CHEMBL4526845 173442 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human adenosine receptor A3 expressed in CHO cells assessed as suppression of NECA-induced decrease of cAMP accumulation by Glo-sensor cAMP assayAntagonist activity at human adenosine receptor A3 expressed in CHO cells assessed as suppression of NECA-induced decrease of cAMP accumulation by Glo-sensor cAMP assay
ChEMBL 316 1 1 3 3.9 O=c1oc2c(O)cccc2cc1-c1ccc(Br)cc1 10.1021/acs.jmedchem.9b01572
135741974 86307 None 8 Human Functional pIC50 = 6.5 6.5 - 1
Activity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation countingActivity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation counting
ChEMBL 291 2 1 4 2.9 COc1ccc(-c2cc3c4ccccc4[nH]c(=O)n3n2)cc1 10.1016/j.bmc.2012.10.031
CHEMBL2312719 86307 None 8 Human Functional pIC50 = 6.5 6.5 - 1
Activity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation countingActivity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation counting
ChEMBL 291 2 1 4 2.9 COc1ccc(-c2cc3c4ccccc4[nH]c(=O)n3n2)cc1 10.1016/j.bmc.2012.10.031
57388055 75511 None 0 Human Functional pIC50 = 7.5 7.5 -5 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 622 12 6 11 3.1 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(N)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
CHEMBL2042306 75511 None 0 Human Functional pIC50 = 7.5 7.5 -5 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 622 12 6 11 3.1 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(N)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
135508372 67271 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 275 1 1 4 3.6 Cc1ccc(-n2cc3c(O)nc4ccccc4c3n2)cc1 10.1021/jm300087j
CHEMBL188035 67271 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 275 1 1 4 3.6 Cc1ccc(-n2cc3c(O)nc4ccccc4c3n2)cc1 10.1021/jm300087j
60156004 77008 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 466 4 3 9 2.0 CC(C)NC(=O)N1CCC(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)CC1 10.1021/jm300323t
CHEMBL2071040 77008 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 466 4 3 9 2.0 CC(C)NC(=O)N1CCC(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)CC1 10.1021/jm300323t
60154740 77017 None 0 Human Functional pIC50 = 7.5 7.5 95 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 544 6 3 10 2.8 COc1ccc(CNC(=O)N2CCC(NC(=O)Nc3nc4nn(C)cc4c4nc(-c5ccco5)nn34)CC2)cc1 10.1021/jm300323t
CHEMBL2071049 77017 None 0 Human Functional pIC50 = 7.5 7.5 95 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 544 6 3 10 2.8 COc1ccc(CNC(=O)N2CCC(NC(=O)Nc3nc4nn(C)cc4c4nc(-c5ccco5)nn34)CC2)cc1 10.1021/jm300323t
136086896 63608 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 325 3 1 5 1.7 C=CCN1C(=O)N2CC(C)N=C2c2[nH]c(-c3cc(C)nn3C)nc21 10.1021/jm2004738
CHEMBL1800733 63608 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 325 3 1 5 1.7 C=CCN1C(=O)N2CC(C)N=C2c2[nH]c(-c3cc(C)nn3C)nc21 10.1021/jm2004738
136025838 63609 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 325 3 1 5 1.7 C=CCN1C(=O)N2C[C@@H](C)N=C2c2[nH]c(-c3cc(C)nn3C)nc21 10.1021/jm2004738
CHEMBL1800734 63609 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 325 3 1 5 1.7 C=CCN1C(=O)N2C[C@@H](C)N=C2c2[nH]c(-c3cc(C)nn3C)nc21 10.1021/jm2004738
25230951 150387 None 0 Human Functional pIC50 = 6.4 6.4 -9 4
Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.
ChEMBL 380 6 1 7 4.6 CCc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1 nan
CHEMBL3952824 150387 None 0 Human Functional pIC50 = 6.4 6.4 -9 4
Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.
ChEMBL 380 6 1 7 4.6 CCc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1 nan
127034991 137520 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 398 4 1 7 4.2 O=C(Nc1nc(-c2cccs2)nc2cn(-c3ccccc3)nc12)c1ccncc1 10.1016/j.ejmech.2015.11.015
CHEMBL3753507 137520 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 398 4 1 7 4.2 O=C(Nc1nc(-c2cccs2)nc2cn(-c3ccccc3)nc12)c1ccncc1 10.1016/j.ejmech.2015.11.015
25230948 6037 None 0 Human Functional pIC50 = 7.4 7.4 -3 4
Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.
ChEMBL 395 7 2 8 4.4 CCNc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1 nan
CHEMBL1080421 6037 None 0 Human Functional pIC50 = 7.4 7.4 -3 4
Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.
ChEMBL 395 7 2 8 4.4 CCNc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1 nan
127036925 137389 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 422 5 1 7 4.1 COc1ccc(-c2nc(NC(=O)c3ccncc3)c3nn(-c4ccccc4)cc3n2)cc1 10.1016/j.ejmech.2015.11.015
CHEMBL3752438 137389 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 422 5 1 7 4.1 COc1ccc(-c2nc(NC(=O)c3ccncc3)c3nn(-c4ccccc4)cc3n2)cc1 10.1016/j.ejmech.2015.11.015
135401232 3206 None 4 Human Functional pIC50 = 8.4 8.4 - 1
Inverse agonist activity at human recombinant A3 adenosine receptor expressed CHO cells by [35S]GTPgammaS binding assayInverse agonist activity at human recombinant A3 adenosine receptor expressed CHO cells by [35S]GTPgammaS binding assay
ChEMBL 397 2 1 3 4.4 CC[C@H]1N=c2n(C1)c(=O)n(c1c2[nH]c(n1)c1cc(Cl)cc(c1Cl)Cl)C 10.1021/jm2004738
5619 3206 None 4 Human Functional pIC50 = 8.4 8.4 - 1
Inverse agonist activity at human recombinant A3 adenosine receptor expressed CHO cells by [35S]GTPgammaS binding assayInverse agonist activity at human recombinant A3 adenosine receptor expressed CHO cells by [35S]GTPgammaS binding assay
ChEMBL 397 2 1 3 4.4 CC[C@H]1N=c2n(C1)c(=O)n(c1c2[nH]c(n1)c1cc(Cl)cc(c1Cl)Cl)C 10.1021/jm2004738
CHEMBL1562432 3206 None 4 Human Functional pIC50 = 8.4 8.4 - 1
Inverse agonist activity at human recombinant A3 adenosine receptor expressed CHO cells by [35S]GTPgammaS binding assayInverse agonist activity at human recombinant A3 adenosine receptor expressed CHO cells by [35S]GTPgammaS binding assay
ChEMBL 397 2 1 3 4.4 CC[C@H]1N=c2n(C1)c(=O)n(c1c2[nH]c(n1)c1cc(Cl)cc(c1Cl)Cl)C 10.1021/jm2004738
10623248 112703 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 2.9-6.0Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 2.9-6.0
ChEMBL 446 7 2 9 4.2 CCCCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm001047y
CHEMBL330286 112703 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 2.9-6.0Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 2.9-6.0
ChEMBL 446 7 2 9 4.2 CCCCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm001047y
11144868 119936 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 2.7-6.6Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 2.7-6.6
ChEMBL 452 3 2 8 3.7 Cn1cc2c(nc(NC(=O)Nc3ccc(Br)cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
CHEMBL348925 119936 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 2.7-6.6Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 2.7-6.6
ChEMBL 452 3 2 8 3.7 Cn1cc2c(nc(NC(=O)Nc3ccc(Br)cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
168278037 190318 None 0 Human Functional pIC50 = 8.4 8.4 -3 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 364 4 3 5 4.4 Cn1nc(NC(=O)Nc2ccccc2)c2ccnc(NC3CCCCC3)c21 10.1021/acs.jmedchem.2c01123
CHEMBL5174600 190318 None 0 Human Functional pIC50 = 8.4 8.4 -3 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 364 4 3 5 4.4 Cn1nc(NC(=O)Nc2ccccc2)c2ccnc(NC3CCCCC3)c21 10.1021/acs.jmedchem.2c01123
127037423 137527 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 451 6 1 7 4.8 COc1ccc(C(=O)Nc2nc(-c3ccc(OC)cc3)nc3cn(-c4ccccc4)nc23)cc1 10.1016/j.ejmech.2015.11.015
CHEMBL3753544 137527 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 451 6 1 7 4.8 COc1ccc(C(=O)Nc2nc(-c3ccc(OC)cc3)nc3cn(-c4ccccc4)nc23)cc1 10.1016/j.ejmech.2015.11.015
127037424 137577 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 481 5 0 9 5.2 O=C(c1ccco1)N(C(=O)c1ccco1)c1nc(-c2cccs2)nc2cn(-c3ccccc3)nc12 10.1016/j.ejmech.2015.11.015
CHEMBL3753976 137577 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 481 5 0 9 5.2 O=C(c1ccco1)N(C(=O)c1ccco1)c1nc(-c2cccs2)nc2cn(-c3ccccc3)nc12 10.1016/j.ejmech.2015.11.015
10647227 165549 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 3.0-6.9Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 3.0-6.9
ChEMBL 450 6 2 8 4.8 CCCCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1021/jm001047y
CHEMBL423934 165549 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 3.0-6.9Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 3.0-6.9
ChEMBL 450 6 2 8 4.8 CCCCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1021/jm001047y
459 2618 None 29 Human Functional pIC50 = 8.4 8.4 - 1
Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human Adenosine A3 receptorInhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human Adenosine A3 receptor
ChEMBL 432 6 2 9 3.8 CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC 10.1021/jm991114s
477 2618 None 29 Human Functional pIC50 = 8.4 8.4 - 1
Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human Adenosine A3 receptorInhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human Adenosine A3 receptor
ChEMBL 432 6 2 9 3.8 CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC 10.1021/jm991114s
5310960 2618 None 29 Human Functional pIC50 = 8.4 8.4 - 1
Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human Adenosine A3 receptorInhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human Adenosine A3 receptor
ChEMBL 432 6 2 9 3.8 CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC 10.1021/jm991114s
CHEMBL302765 2618 None 29 Human Functional pIC50 = 8.4 8.4 - 1
Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human Adenosine A3 receptorInhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human Adenosine A3 receptor
ChEMBL 432 6 2 9 3.8 CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC 10.1021/jm991114s
10905184 120204 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 2.7-7.8Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 2.7-7.8
ChEMBL 388 3 2 8 3.2 Cc1ccc(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1 10.1021/jm0109614
CHEMBL351285 120204 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 2.7-7.8Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 2.7-7.8
ChEMBL 388 3 2 8 3.2 Cc1ccc(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1 10.1021/jm0109614
9953799 205832 None 2 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 2.5-9.3Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 2.5-9.3
ChEMBL 418 5 2 9 3.4 CCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm001047y
CHEMBL65271 205832 None 2 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 2.5-9.3Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 2.5-9.3
ChEMBL 418 5 2 9 3.4 CCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm001047y
9822747 119445 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 2.8-8.1Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 2.8-8.1
ChEMBL 408 3 2 8 3.6 Cn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1021/jm001047y
CHEMBL344501 119445 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 2.8-8.1Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 2.8-8.1
ChEMBL 408 3 2 8 3.6 Cn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1021/jm001047y
168286347 191801 None 0 Human Functional pIC50 = 8.3 8.3 4 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 405 7 3 7 3.9 COc1cc(Nc2nc(CN)cc3c(-c4ccccc4)n[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
CHEMBL5196781 191801 None 0 Human Functional pIC50 = 8.3 8.3 4 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 405 7 3 7 3.9 COc1cc(Nc2nc(CN)cc3c(-c4ccccc4)n[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
60155894 76999 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 496 5 2 10 2.9 Cn1cc2c(nc(NC(=O)NC3CCN(Cc4ccc(C#N)cc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2070891 76999 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 496 5 2 10 2.9 Cn1cc2c(nc(NC(=O)NC3CCN(Cc4ccc(C#N)cc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
10779327 119473 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human Adenosine A3 receptorInhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human Adenosine A3 receptor
ChEMBL 283 3 1 8 1.7 CCCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1 10.1021/jm991114s
CHEMBL344706 119473 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human Adenosine A3 receptorInhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human Adenosine A3 receptor
ChEMBL 283 3 1 8 1.7 CCCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1 10.1021/jm991114s
136086897 63610 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 325 3 1 5 1.7 C=CCN1C(=O)N2C[C@H](C)N=C2c2[nH]c(-c3cc(C)nn3C)nc21 10.1021/jm2004738
CHEMBL1800735 63610 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counterAntagonist activity human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation after 150 mins by scintillation counter
ChEMBL 325 3 1 5 1.7 C=CCN1C(=O)N2C[C@H](C)N=C2c2[nH]c(-c3cc(C)nn3C)nc21 10.1021/jm2004738
2690 903 None 44 Human Functional pIC50 = 6.4 6.4 -123 5
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptorInhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor
ChEMBL 285 1 1 6 2.8 Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1 10.1021/jm001047y
384 903 None 44 Human Functional pIC50 = 6.4 6.4 -123 5
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptorInhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor
ChEMBL 285 1 1 6 2.8 Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1 10.1021/jm001047y
CHEMBL16687 903 None 44 Human Functional pIC50 = 6.4 6.4 -123 5
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptorInhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor
ChEMBL 285 1 1 6 2.8 Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1 10.1021/jm001047y
2861880 111208 None 13 Human Functional pIC50 = 6.4 6.4 - 1
Inhibition of [35S]GTP-gamma-S, binding stimulated by 5 uM 5''-N-ethyluronamidoadenosine (NECA) in membranes of HEK293 cells expressing human Adenosine A3 receptorInhibition of [35S]GTP-gamma-S, binding stimulated by 5 uM 5''-N-ethyluronamidoadenosine (NECA) in membranes of HEK293 cells expressing human Adenosine A3 receptor
ChEMBL 466 8 2 4 4.9 CCOC(=O)CNC(c1ccccc1)c1cc(Br)ccc1NC(=O)c1ccccc1 10.1016/s0960-894x(99)00583-1
CHEMBL326389 111208 None 13 Human Functional pIC50 = 6.4 6.4 - 1
Inhibition of [35S]GTP-gamma-S, binding stimulated by 5 uM 5''-N-ethyluronamidoadenosine (NECA) in membranes of HEK293 cells expressing human Adenosine A3 receptorInhibition of [35S]GTP-gamma-S, binding stimulated by 5 uM 5''-N-ethyluronamidoadenosine (NECA) in membranes of HEK293 cells expressing human Adenosine A3 receptor
ChEMBL 466 8 2 4 4.9 CCOC(=O)CNC(c1ccccc1)c1cc(Br)ccc1NC(=O)c1ccccc1 10.1016/s0960-894x(99)00583-1
60156002 77005 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 467 6 2 11 1.4 CCOC(=O)CN1CCC(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)CC1 10.1021/jm300323t
CHEMBL2071038 77005 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 467 6 2 11 1.4 CCOC(=O)CN1CCC(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)CC1 10.1021/jm300323t
25212376 174298 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay
ChEMBL 365 3 1 5 4.2 O=C(Nc1nc2ccccc2c2cn(-c3ccccc3)nc12)c1ccncc1 10.1016/j.bmc.2008.10.018
CHEMBL454780 174298 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay
ChEMBL 365 3 1 5 4.2 O=C(Nc1nc2ccccc2c2cn(-c3ccccc3)nc12)c1ccncc1 10.1016/j.bmc.2008.10.018
137658761 159275 None 0 Human Functional pIC50 = 5.4 5.4 -74 3
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-stimulated adenylyl cyclase in presence of [alpha-31P]ATPAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-stimulated adenylyl cyclase in presence of [alpha-31P]ATP
ChEMBL 413 4 3 8 2.2 O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(Nc4ccc(Cl)cc4F)ncnc32)[C@@H]1O 10.1021/acs.jmedchem.7b01399
CHEMBL4098408 159275 None 0 Human Functional pIC50 = 5.4 5.4 -74 3
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-stimulated adenylyl cyclase in presence of [alpha-31P]ATPAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-stimulated adenylyl cyclase in presence of [alpha-31P]ATP
ChEMBL 413 4 3 8 2.2 O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(Nc4ccc(Cl)cc4F)ncnc32)[C@@H]1O 10.1021/acs.jmedchem.7b01399
118733028 118605 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity against human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-induced inhibition of forskolin-induced cAMP production by scintillation counting methodAntagonist activity against human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-induced inhibition of forskolin-induced cAMP production by scintillation counting method
ChEMBL 277 1 1 4 3.0 Cc1nc2sc(-c3ccc(Cl)cc3)nc2c(=O)[nH]1 10.1016/j.ejmech.2015.04.010
CHEMBL3415025 118605 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity against human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-induced inhibition of forskolin-induced cAMP production by scintillation counting methodAntagonist activity against human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-induced inhibition of forskolin-induced cAMP production by scintillation counting method
ChEMBL 277 1 1 4 3.0 Cc1nc2sc(-c3ccc(Cl)cc3)nc2c(=O)[nH]1 10.1016/j.ejmech.2015.04.010
60155895 77000 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 516 6 2 11 3.0 Cn1cc2c(nc(NC(=O)NC3CCN(Cc4ccc([N+](=O)[O-])cc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2070892 77000 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 516 6 2 11 3.0 Cn1cc2c(nc(NC(=O)NC3CCN(Cc4ccc([N+](=O)[O-])cc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
46877289 204910 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Inhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptorInhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptor
ChEMBL 560 9 5 11 0.0 C=CCN(C)S(=O)(=O)c1ccc(NC(=O)Nc2ncnc3c2ncn3C2O[C@H](C(=O)NCC)[C@@H](O)[C@H]2O)cc1 10.1021/jm0408161
CHEMBL611095 204910 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Inhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptorInhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptor
ChEMBL 560 9 5 11 0.0 C=CCN(C)S(=O)(=O)c1ccc(NC(=O)Nc2ncnc3c2ncn3C2O[C@H](C(=O)NCC)[C@@H](O)[C@H]2O)cc1 10.1021/jm0408161
139248514 167158 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as reduction in Cl-IB-MECA-induced inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 10 mins followed by Cl-IB-MECA addition measured after 30 mins by liquid scintillation counting methodAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as reduction in Cl-IB-MECA-induced inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 10 mins followed by Cl-IB-MECA addition measured after 30 mins by liquid scintillation counting method
ChEMBL 331 7 1 5 4.1 CCCOc1cc(NC(C)=O)nc(S[C@@H](C)c2ccccc2)n1 10.1039/C7MD00375G
CHEMBL4289256 167158 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as reduction in Cl-IB-MECA-induced inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 10 mins followed by Cl-IB-MECA addition measured after 30 mins by liquid scintillation counting methodAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as reduction in Cl-IB-MECA-induced inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 10 mins followed by Cl-IB-MECA addition measured after 30 mins by liquid scintillation counting method
ChEMBL 331 7 1 5 4.1 CCCOc1cc(NC(C)=O)nc(S[C@@H](C)c2ccccc2)n1 10.1039/C7MD00375G
60156006 77010 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 506 4 3 9 2.9 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NC4CCCCC4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2071042 77010 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 506 4 3 9 2.9 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NC4CCCCC4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
10961304 76039 None 0 Human Functional pIC50 = 7.4 7.4 1 2
Antagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECAAntagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECA
ChEMBL 447 6 3 10 3.4 CCNc1c2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)nn1C 10.1021/jm021023m
CHEMBL20555 76039 None 0 Human Functional pIC50 = 7.4 7.4 1 2
Antagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECAAntagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECA
ChEMBL 447 6 3 10 3.4 CCNc1c2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)nn1C 10.1021/jm021023m
CHEMBL554955 76039 None 0 Human Functional pIC50 = 7.4 7.4 1 2
Antagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECAAntagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECA
ChEMBL 447 6 3 10 3.4 CCNc1c2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)nn1C 10.1021/jm021023m
60155893 76998 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 501 6 2 10 3.1 COc1ccc(CN2CCC(NC(=O)Nc3nc4nn(C)cc4c4nc(-c5ccco5)nn34)CC2)cc1 10.1021/jm300323t
CHEMBL2070890 76998 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 501 6 2 10 3.1 COc1ccc(CN2CCC(NC(=O)Nc3nc4nn(C)cc4c4nc(-c5ccco5)nn34)CC2)cc1 10.1021/jm300323t
60156107 77013 None 0 Human Functional pIC50 = 7.3 7.3 33 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 542 7 3 9 3.2 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCCCc4ccccc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2071045 77013 None 0 Human Functional pIC50 = 7.3 7.3 33 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 542 7 3 9 3.2 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCCCc4ccccc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
10917575 81175 None 0 Human Functional pIC50 = 6.3 6.3 -21 2
Antagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECAAntagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECA
ChEMBL 463 5 1 11 2.9 CSc1c2c(nc(NC(=O)Cc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)nn1C 10.1021/jm021023m
CHEMBL21572 81175 None 0 Human Functional pIC50 = 6.3 6.3 -21 2
Antagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECAAntagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECA
ChEMBL 463 5 1 11 2.9 CSc1c2c(nc(NC(=O)Cc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)nn1C 10.1021/jm021023m
44562753 190010 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay
ChEMBL 368 3 1 5 4.7 Cc1ccc(C(=O)Nc2nc3ccccc3c3cn(-c4ccccc4)nc23)o1 10.1016/j.bmc.2008.10.018
CHEMBL516966 190010 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay
ChEMBL 368 3 1 5 4.7 Cc1ccc(C(=O)Nc2nc3ccccc3c3cn(-c4ccccc4)nc23)o1 10.1016/j.bmc.2008.10.018
9869857 66851 None 12 Human Functional pIC50 = 8.3 8.3 -1 5
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 482 8 5 14 -0.6 CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1 10.1021/jm300087j
CHEMBL186113 66851 None 12 Human Functional pIC50 = 8.3 8.3 -1 5
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 482 8 5 14 -0.6 CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1 10.1021/jm300087j
11209919 168474 None 1 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 337 4 1 6 1.9 CCCn1c(=O)c2c(nc3[nH]c(C)cn32)n(Cc2ccccc2)c1=O 10.1021/jm300087j
CHEMBL434534 168474 None 1 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 337 4 1 6 1.9 CCCn1c(=O)c2c(nc3[nH]c(C)cn32)n(Cc2ccccc2)c1=O 10.1021/jm300087j
10765059 102750 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 3.5-7.6Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 3.5-7.6
ChEMBL 430 6 2 9 3.6 C=CCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm001047y
CHEMBL304726 102750 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 3.5-7.6Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 3.5-7.6
ChEMBL 430 6 2 9 3.6 C=CCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm001047y
134140759 147412 None 0 Human Functional pIC50 = 8.3 8.3 -2 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 376 6 2 6 4.4 COc1cc(Nc2nccc3c(-c4ccccc4)n[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
CHEMBL3929143 147412 None 0 Human Functional pIC50 = 8.3 8.3 -2 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 376 6 2 6 4.4 COc1cc(Nc2nccc3c(-c4ccccc4)n[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
459 2618 None 29 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 4.4-6.5Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 4.4-6.5
ChEMBL 432 6 2 9 3.8 CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC 10.1021/jm001047y
477 2618 None 29 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 4.4-6.5Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 4.4-6.5
ChEMBL 432 6 2 9 3.8 CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC 10.1021/jm001047y
5310960 2618 None 29 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 4.4-6.5Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 4.4-6.5
ChEMBL 432 6 2 9 3.8 CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC 10.1021/jm001047y
CHEMBL302765 2618 None 29 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 4.4-6.5Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 4.4-6.5
ChEMBL 432 6 2 9 3.8 CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC 10.1021/jm001047y
135515507 34133 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of cAMP accumulation in CHO cells expressing human A3 adenosine receptorInhibition of cAMP accumulation in CHO cells expressing human A3 adenosine receptor
ChEMBL 394 3 3 7 3.6 O=C(Nc1cccc(Cl)c1)Nc1nc2n[nH]cc2c2nc(-c3ccco3)nn12 10.1021/jm001047y
CHEMBL142562 34133 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of cAMP accumulation in CHO cells expressing human A3 adenosine receptorInhibition of cAMP accumulation in CHO cells expressing human A3 adenosine receptor
ChEMBL 394 3 3 7 3.6 O=C(Nc1cccc(Cl)c1)Nc1nc2n[nH]cc2c2nc(-c3ccco3)nn12 10.1021/jm001047y
9910926 29339 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human A3 receptorInhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human A3 receptor
ChEMBL 436 5 2 8 4.4 CCCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1021/jm991114s
CHEMBL138332 29339 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human A3 receptorInhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human A3 receptor
ChEMBL 436 5 2 8 4.4 CCCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1021/jm991114s
127036424 137427 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 397 4 1 6 4.8 O=C(Nc1nc(-c2cccs2)nc2cn(-c3ccccc3)nc12)c1ccccc1 10.1016/j.ejmech.2015.11.015
CHEMBL3752840 137427 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 397 4 1 6 4.8 O=C(Nc1nc(-c2cccs2)nc2cn(-c3ccccc3)nc12)c1ccccc1 10.1016/j.ejmech.2015.11.015
127036562 137343 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 387 4 1 7 4.4 O=C(Nc1nc(-c2cccs2)nc2cn(-c3ccccc3)nc12)c1ccco1 10.1016/j.ejmech.2015.11.015
CHEMBL3751978 137343 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 387 4 1 7 4.4 O=C(Nc1nc(-c2cccs2)nc2cn(-c3ccccc3)nc12)c1ccco1 10.1016/j.ejmech.2015.11.015
11133545 120534 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in membranes of CHO cells expressing human Adenosine A3 receptorInhibition of IB-MECA agonist-mediated cAMP production in membranes of CHO cells expressing human Adenosine A3 receptor
ChEMBL 419 4 2 10 2.8 Cn1cc2c(nc(NC(=O)Nc3ccc([N+](=O)[O-])cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
CHEMBL354161 120534 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in membranes of CHO cells expressing human Adenosine A3 receptorInhibition of IB-MECA agonist-mediated cAMP production in membranes of CHO cells expressing human Adenosine A3 receptor
ChEMBL 419 4 2 10 2.8 Cn1cc2c(nc(NC(=O)Nc3ccc([N+](=O)[O-])cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
9910926 29339 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 4.0-7.5Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 4.0-7.5
ChEMBL 436 5 2 8 4.4 CCCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1021/jm001047y
CHEMBL138332 29339 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 4.0-7.5Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 4.0-7.5
ChEMBL 436 5 2 8 4.4 CCCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1021/jm001047y
127036563 137430 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 403 4 1 7 4.9 O=C(Nc1nc(-c2cccs2)nc2cn(-c3ccccc3)nc12)c1cccs1 10.1016/j.ejmech.2015.11.015
CHEMBL3752862 137430 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 403 4 1 7 4.9 O=C(Nc1nc(-c2cccs2)nc2cn(-c3ccccc3)nc12)c1cccs1 10.1016/j.ejmech.2015.11.015
11058550 120195 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 3.0-10.8Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 3.0-10.8
ChEMBL 404 4 2 9 2.9 COc1ccccc1NC(=O)Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12 10.1021/jm0109614
CHEMBL351211 120195 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 3.0-10.8Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 3.0-10.8
ChEMBL 404 4 2 9 2.9 COc1ccccc1NC(=O)Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12 10.1021/jm0109614
46238067 8508 None 0 Human Functional pIC50 = 8.2 8.2 229 2
Antagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry
ChEMBL 420 5 2 5 5.2 O=C(Nc1ccccc1)Nc1nc(-c2ccccc2)nc2nn(Cc3ccccc3)cc12 10.1021/jm901785w
CHEMBL1094132 8508 None 0 Human Functional pIC50 = 8.2 8.2 229 2
Antagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry
ChEMBL 420 5 2 5 5.2 O=C(Nc1ccccc1)Nc1nc(-c2ccccc2)nc2nn(Cc3ccccc3)cc12 10.1021/jm901785w
60155799 76997 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 485 5 2 9 3.4 Cc1ccc(CN2CCC(NC(=O)Nc3nc4nn(C)cc4c4nc(-c5ccco5)nn34)CC2)cc1 10.1021/jm300323t
CHEMBL2070889 76997 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 485 5 2 9 3.4 Cc1ccc(CN2CCC(NC(=O)Nc3nc4nn(C)cc4c4nc(-c5ccco5)nn34)CC2)cc1 10.1021/jm300323t
57395120 69802 None 0 Human Functional pIC50 = 7.3 7.3 18 2
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by competition protein binding assay
ChEMBL 431 6 2 8 4.4 CCCn1cc2nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc3c2c1 10.1016/j.bmc.2011.11.037
CHEMBL1935748 69802 None 0 Human Functional pIC50 = 7.3 7.3 18 2
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by competition protein binding assay
ChEMBL 431 6 2 8 4.4 CCCn1cc2nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc3c2c1 10.1016/j.bmc.2011.11.037
46877285 204908 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Inhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptorInhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptor
ChEMBL 562 9 5 11 0.3 CCNC(=O)[C@H]1OC(n2cnc3c(NC(=O)Nc4ccc(S(=O)(=O)N(CC)CC)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm0408161
CHEMBL611091 204908 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Inhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptorInhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptor
ChEMBL 562 9 5 11 0.3 CCNC(=O)[C@H]1OC(n2cnc3c(NC(=O)Nc4ccc(S(=O)(=O)N(CC)CC)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm0408161
57400352 69808 None 0 Human Functional pIC50 = 6.3 6.3 -12 2
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by competition protein binding assay
ChEMBL 283 3 1 8 1.7 CCCn1ncc2nc(N)n3nc(-c4ccco4)nc3c21 10.1016/j.bmc.2011.11.037
CHEMBL1935753 69808 None 0 Human Functional pIC50 = 6.3 6.3 -12 2
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by competition protein binding assay
ChEMBL 283 3 1 8 1.7 CCCn1ncc2nc(N)n3nc(-c4ccco4)nc3c21 10.1016/j.bmc.2011.11.037
46238064 8512 None 0 Human Functional pIC50 = 7.3 7.3 5 2
Antagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry
ChEMBL 405 5 1 5 4.8 O=C(Nc1nc(-c2ccccc2)nc2nn(Cc3ccccc3)cc12)c1ccccc1 10.1021/jm901785w
CHEMBL1094143 8512 None 0 Human Functional pIC50 = 7.3 7.3 5 2
Antagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry
ChEMBL 405 5 1 5 4.8 O=C(Nc1nc(-c2ccccc2)nc2nn(Cc3ccccc3)cc12)c1ccccc1 10.1021/jm901785w
44570242 190840 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay
ChEMBL 378 3 1 4 5.1 Cc1ccc(C(=O)Nc2nc3ccccc3c3cn(-c4ccccc4)nc23)cc1 10.1016/j.bmc.2008.10.018
CHEMBL518258 190840 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay
ChEMBL 378 3 1 4 5.1 Cc1ccc(C(=O)Nc2nc3ccccc3c3cn(-c4ccccc4)nc23)cc1 10.1016/j.bmc.2008.10.018
46876751 204538 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Inhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptorInhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptor
ChEMBL 562 8 5 11 0.3 CCNC(=O)[C@H]1OC(n2cnc3c(NC(=O)Nc4ccc(S(=O)(=O)N(C)C(C)C)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm0408161
CHEMBL608755 204538 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Inhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptorInhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptor
ChEMBL 562 8 5 11 0.3 CCNC(=O)[C@H]1OC(n2cnc3c(NC(=O)Nc4ccc(S(=O)(=O)N(C)C(C)C)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm0408161
11014188 118547 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in membranes of CHO cells expressing human Adenosine A3 receptorInhibition of IB-MECA agonist-mediated cAMP production in membranes of CHO cells expressing human Adenosine A3 receptor
ChEMBL 373 4 1 8 2.5 Cn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
CHEMBL341376 118547 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in membranes of CHO cells expressing human Adenosine A3 receptorInhibition of IB-MECA agonist-mediated cAMP production in membranes of CHO cells expressing human Adenosine A3 receptor
ChEMBL 373 4 1 8 2.5 Cn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
9953799 205832 None 2 Human Functional pIC50 = 8.2 8.2 - 1
Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human A3 receptorInhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human A3 receptor
ChEMBL 418 5 2 9 3.4 CCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm991114s
CHEMBL65271 205832 None 2 Human Functional pIC50 = 8.2 8.2 - 1
Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human A3 receptorInhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human A3 receptor
ChEMBL 418 5 2 9 3.4 CCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm991114s
10993916 57172 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 3.7-117Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 3.7-117
ChEMBL 442 3 2 8 3.9 Cn1cc2c(nc(NC(=O)Nc3ccc(C(F)(F)F)cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
CHEMBL164686 57172 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 3.7-117Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 3.7-117
ChEMBL 442 3 2 8 3.9 Cn1cc2c(nc(NC(=O)Nc3ccc(C(F)(F)F)cc3)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
168280255 191081 None 0 Human Functional pIC50 = 8.2 8.2 -1 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 343 4 2 5 4.0 Cn1nc(NC(=O)c2ccccc2)c2cc(Nc3ccccc3)ncc21 10.1021/acs.jmedchem.2c01123
CHEMBL5186062 191081 None 0 Human Functional pIC50 = 8.2 8.2 -1 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 343 4 2 5 4.0 Cn1nc(NC(=O)c2ccccc2)c2cc(Nc3ccccc3)ncc21 10.1021/acs.jmedchem.2c01123
9824812 121206 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 5.1-8.9Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 5.1-8.9
ChEMBL 446 4 2 9 4.1 COc1ccc(NC(=O)Nc2nc3nn(C(C)(C)C)cc3c3nc(-c4ccco4)nn23)cc1 10.1021/jm001047y
CHEMBL357663 121206 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 5.1-8.9Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 5.1-8.9
ChEMBL 446 4 2 9 4.1 COc1ccc(NC(=O)Nc2nc3nn(C(C)(C)C)cc3c3nc(-c4ccco4)nn23)cc1 10.1021/jm001047y
168272324 190685 None 0 Human Functional pIC50 = 7.2 7.2 -4 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 311 3 2 4 4.2 N#Cc1cc2c(-c3ccccc3)n[nH]c2c(Nc2ccccc2)n1 10.1021/acs.jmedchem.2c01123
CHEMBL5180268 190685 None 0 Human Functional pIC50 = 7.2 7.2 -4 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 311 3 2 4 4.2 N#Cc1cc2c(-c3ccccc3)n[nH]c2c(Nc2ccccc2)n1 10.1021/acs.jmedchem.2c01123
57384287 75506 None 0 Human Functional pIC50 = 4.2 4.2 -1348 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 658 9 6 11 3.7 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)cc(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
CHEMBL2042301 75506 None 0 Human Functional pIC50 = 4.2 4.2 -1348 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 658 9 6 11 3.7 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)cc(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
71601933 86942 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Inhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECAInhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECA
ChEMBL 405 5 1 5 4.7 O=C(Cc1ccccc1)Nc1nc(-c2ccccc2)nc2cn(-c3ccccc3)nc12 10.1021/jm400068e
CHEMBL2322898 86942 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Inhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECAInhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECA
ChEMBL 405 5 1 5 4.7 O=C(Cc1ccccc1)Nc1nc(-c2ccccc2)nc2cn(-c3ccccc3)nc12 10.1021/jm400068e
71602201 86951 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Inhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECAInhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECA
ChEMBL 421 5 1 6 4.7 COc1ccc(-n2cc3nc(-c4ccccc4)nc(NC(=O)c4ccccc4)c3n2)cc1 10.1021/jm400068e
CHEMBL2322907 86951 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Inhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECAInhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECA
ChEMBL 421 5 1 6 4.7 COc1ccc(-n2cc3nc(-c4ccccc4)nc(NC(=O)c4ccccc4)c3n2)cc1 10.1021/jm400068e
46877325 204912 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Inhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptorInhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptor
ChEMBL 586 11 5 11 0.6 C=CCN(CC=C)S(=O)(=O)c1ccc(NC(=O)Nc2ncnc3c2ncn3C2O[C@H](C(=O)NCC)[C@@H](O)[C@H]2O)cc1 10.1021/jm0408161
CHEMBL611104 204912 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Inhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptorInhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptor
ChEMBL 586 11 5 11 0.6 C=CCN(CC=C)S(=O)(=O)c1ccc(NC(=O)Nc2ncnc3c2ncn3C2O[C@H](C(=O)NCC)[C@@H](O)[C@H]2O)cc1 10.1021/jm0408161
71601931 86968 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Inhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECAInhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECA
ChEMBL 391 4 1 5 4.7 O=C(Nc1nc(-c2ccccc2)nc2cn(-c3ccccc3)nc12)c1ccccc1 10.1021/jm400068e
CHEMBL2322930 86968 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Inhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECAInhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECA
ChEMBL 391 4 1 5 4.7 O=C(Nc1nc(-c2ccccc2)nc2cn(-c3ccccc3)nc12)c1ccccc1 10.1021/jm400068e
377 2758 None 42 Human Functional pIC50 = 4.2 4.2 -3 10
Inhibition of forskolin-stimulated cAMP accumulation in chinese hamster ovary cell membranes expressing human adenosine A3 receptorInhibition of forskolin-stimulated cAMP accumulation in chinese hamster ovary cell membranes expressing human adenosine A3 receptor
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm031092g
425 2758 None 42 Human Functional pIC50 = 4.2 4.2 -3 10
Inhibition of forskolin-stimulated cAMP accumulation in chinese hamster ovary cell membranes expressing human adenosine A3 receptorInhibition of forskolin-stimulated cAMP accumulation in chinese hamster ovary cell membranes expressing human adenosine A3 receptor
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm031092g
448222 2758 None 42 Human Functional pIC50 = 4.2 4.2 -3 10
Inhibition of forskolin-stimulated cAMP accumulation in chinese hamster ovary cell membranes expressing human adenosine A3 receptorInhibition of forskolin-stimulated cAMP accumulation in chinese hamster ovary cell membranes expressing human adenosine A3 receptor
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm031092g
CHEMBL464859 2758 None 42 Human Functional pIC50 = 4.2 4.2 -3 10
Inhibition of forskolin-stimulated cAMP accumulation in chinese hamster ovary cell membranes expressing human adenosine A3 receptorInhibition of forskolin-stimulated cAMP accumulation in chinese hamster ovary cell membranes expressing human adenosine A3 receptor
ChEMBL 308 3 4 9 -1.8 CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1021/jm031092g
10438449 206966 None 0 Human Functional pIC50 = 5.2 5.2 3 2
Inhibition of forskolin-stimulated cAMP accumulation in chinese hamster ovary cell membranes expressing human adenosine A3 receptorInhibition of forskolin-stimulated cAMP accumulation in chinese hamster ovary cell membranes expressing human adenosine A3 receptor
ChEMBL 593 10 3 14 2.3 CO/C(=C\c1ccc(O)cc1)C(=O)O[C@@H]1[C@H](OC(=O)/C=C/c2c[nH]cn2)[C@@H](CSC)O[C@H]1n1cnc2c(N)ncnc21 10.1021/jm031092g
CHEMBL72613 206966 None 0 Human Functional pIC50 = 5.2 5.2 3 2
Inhibition of forskolin-stimulated cAMP accumulation in chinese hamster ovary cell membranes expressing human adenosine A3 receptorInhibition of forskolin-stimulated cAMP accumulation in chinese hamster ovary cell membranes expressing human adenosine A3 receptor
ChEMBL 593 10 3 14 2.3 CO/C(=C\c1ccc(O)cc1)C(=O)O[C@@H]1[C@H](OC(=O)/C=C/c2c[nH]cn2)[C@@H](CSC)O[C@H]1n1cnc2c(N)ncnc21 10.1021/jm031092g
57387596 75516 None 0 Human Functional pIC50 = 8.2 8.2 -3 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 492 7 4 9 1.6 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(F)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
CHEMBL2042311 75516 None 0 Human Functional pIC50 = 8.2 8.2 -3 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 492 7 4 9 1.6 CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(F)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
393595 2637 None 36 Human Functional pIC50 = 8.1 8.1 16 3
Antagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assay
ChEMBL 403 4 1 6 4.4 O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1 10.1021/jm300087j
448 2637 None 36 Human Functional pIC50 = 8.1 8.1 16 3
Antagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assay
ChEMBL 403 4 1 6 4.4 O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1 10.1021/jm300087j
CHEMBL88147 2637 None 36 Human Functional pIC50 = 8.1 8.1 16 3
Antagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assay
ChEMBL 403 4 1 6 4.4 O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1 10.1021/jm300087j
168278837 191005 None 0 Human Functional pIC50 = 8.1 8.1 -1 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 495 10 3 7 5.7 COc1cc(Nc2nc(CNCc3ccccc3)cc3c(-c4ccccc4)n[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
CHEMBL5185003 191005 None 0 Human Functional pIC50 = 8.1 8.1 -1 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 495 10 3 7 5.7 COc1cc(Nc2nc(CNCc3ccccc3)cc3c(-c4ccccc4)n[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
46238066 8507 None 0 Human Functional pIC50 = 8.1 8.1 173 2
Antagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry
ChEMBL 439 5 1 5 5.4 O=C(Nc1nc(-c2ccccc2)nc2nn(Cc3ccccc3)cc12)c1cccc(Cl)c1 10.1021/jm901785w
CHEMBL1094131 8507 None 0 Human Functional pIC50 = 8.1 8.1 173 2
Antagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry
ChEMBL 439 5 1 5 5.4 O=C(Nc1nc(-c2ccccc2)nc2nn(Cc3ccccc3)cc12)c1cccc(Cl)c1 10.1021/jm901785w
11811544 57221 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 5.5-10.9Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 5.5-10.9
ChEMBL 404 4 2 9 2.9 COc1cccc(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)c1 10.1021/jm0109614
CHEMBL164992 57221 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 5.5-10.9Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 5.5-10.9
ChEMBL 404 4 2 9 2.9 COc1cccc(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)c1 10.1021/jm0109614
10761731 102953 None 2 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 371 4 2 5 4.3 COc1ccccc1NC(=O)Nc1nc(-c2ccccn2)nc2ccccc12 10.1021/jm300087j
CHEMBL305975 102953 None 2 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counterAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
ChEMBL 371 4 2 5 4.3 COc1ccccc1NC(=O)Nc1nc(-c2ccccn2)nc2ccccc12 10.1021/jm300087j
139248513 166779 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as reduction in Cl-IB-MECA-induced inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 10 mins followed by Cl-IB-MECA addition measured after 30 mins by liquid scintillation counting methodAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as reduction in Cl-IB-MECA-induced inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 10 mins followed by Cl-IB-MECA addition measured after 30 mins by liquid scintillation counting method
ChEMBL 331 7 1 5 4.1 CCCSc1nc(NC(C)=O)cc(O[C@@H](C)c2ccccc2)n1 10.1039/C7MD00375G
CHEMBL4282074 166779 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as reduction in Cl-IB-MECA-induced inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 10 mins followed by Cl-IB-MECA addition measured after 30 mins by liquid scintillation counting methodAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as reduction in Cl-IB-MECA-induced inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 10 mins followed by Cl-IB-MECA addition measured after 30 mins by liquid scintillation counting method
ChEMBL 331 7 1 5 4.1 CCCSc1nc(NC(C)=O)cc(O[C@@H](C)c2ccccc2)n1 10.1039/C7MD00375G
137652383 157487 None 0 Human Functional pIC50 = 6.2 6.2 7 2
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-stimulated adenylyl cyclase in presence of [alpha-31P]ATPAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-stimulated adenylyl cyclase in presence of [alpha-31P]ATP
ChEMBL 507 5 3 10 3.1 Cc1cc(C)n(C[C@H]2O[C@@H](n3cnc4c(Nc5ccc(Cl)cc5F)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b01399
CHEMBL4078360 157487 None 0 Human Functional pIC50 = 6.2 6.2 7 2
Antagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-stimulated adenylyl cyclase in presence of [alpha-31P]ATPAntagonist activity at recombinant human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-stimulated adenylyl cyclase in presence of [alpha-31P]ATP
ChEMBL 507 5 3 10 3.1 Cc1cc(C)n(C[C@H]2O[C@@H](n3cnc4c(Nc5ccc(Cl)cc5F)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1 10.1021/acs.jmedchem.7b01399
439176 98674 None 50 Human Functional pIC50 = 4.2 4.2 -22 2
Inhibition of forskolin-stimulated cAMP accumulation in chinese hamster ovary cell membranes expressing human adenosine A3 receptorInhibition of forskolin-stimulated cAMP accumulation in chinese hamster ovary cell membranes expressing human adenosine A3 receptor
ChEMBL 297 3 3 9 -0.6 CSC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm031092g
CHEMBL277041 98674 None 50 Human Functional pIC50 = 4.2 4.2 -22 2
Inhibition of forskolin-stimulated cAMP accumulation in chinese hamster ovary cell membranes expressing human adenosine A3 receptorInhibition of forskolin-stimulated cAMP accumulation in chinese hamster ovary cell membranes expressing human adenosine A3 receptor
ChEMBL 297 3 3 9 -0.6 CSC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm031092g
25230950 152834 None 0 Human Functional pIC50 = 6.1 6.1 -14 4
Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.
ChEMBL 378 6 1 7 4.6 C=Cc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1 nan
CHEMBL3973260 152834 None 0 Human Functional pIC50 = 6.1 6.1 -14 4
Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.
ChEMBL 378 6 1 7 4.6 C=Cc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1 nan
56950235 69801 None 0 Human Functional pIC50 = 7.1 7.1 10 2
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by competition protein binding assay
ChEMBL 403 4 2 8 3.5 COc1ccc(NC(=O)Nc2nc3cn(C)cc3c3nc(-c4ccco4)nn23)cc1 10.1016/j.bmc.2011.11.037
CHEMBL1935747 69801 None 0 Human Functional pIC50 = 7.1 7.1 10 2
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by competition protein binding assay
ChEMBL 403 4 2 8 3.5 COc1ccc(NC(=O)Nc2nc3cn(C)cc3c3nc(-c4ccco4)nn23)cc1 10.1016/j.bmc.2011.11.037
167312186 190781 None 3 Human Functional pIC50 = 7.1 7.1 2 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 401 6 2 7 4.3 COc1cc(Nc2nc(C#N)cc3c(-c4ccccc4)n[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
CHEMBL5181728 190781 None 3 Human Functional pIC50 = 7.1 7.1 2 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 401 6 2 7 4.3 COc1cc(Nc2nc(C#N)cc3c(-c4ccccc4)n[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
57384288 75507 None 0 Human Functional pIC50 = 6.1 6.1 -53 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 674 9 7 12 3.4 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)c(O)c(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
CHEMBL2042302 75507 None 0 Human Functional pIC50 = 6.1 6.1 -53 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 674 9 7 12 3.4 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)c(O)c(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
44570110 191762 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay
ChEMBL 365 3 1 5 4.2 O=C(Nc1nc2ccccc2c2cn(-c3ccccc3)nc12)c1cccnc1 10.1016/j.bmc.2008.10.018
CHEMBL519614 191762 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay
ChEMBL 365 3 1 5 4.2 O=C(Nc1nc2ccccc2c2cn(-c3ccccc3)nc12)c1cccnc1 10.1016/j.bmc.2008.10.018
127026252 138273 None 0 Human Functional pIC50 = 7.1 7.1 24 2
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 458 5 5 10 0.1 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NC45CC6CC(CC(O)(C6)C4)C5)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.5b01402
CHEMBL3769641 138273 None 0 Human Functional pIC50 = 7.1 7.1 24 2
Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysisAgonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
ChEMBL 458 5 5 10 0.1 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NC45CC6CC(CC(O)(C6)C4)C5)ncnc32)[C@H](O)[C@@H]1O 10.1021/acs.jmedchem.5b01402
57387594 75509 None 0 Human Functional pIC50 = 8.1 8.1 -9 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 506 8 4 9 2.0 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(F)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
CHEMBL2042304 75509 None 0 Human Functional pIC50 = 8.1 8.1 -9 4
Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
ChEMBL 506 8 4 9 2.0 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(F)nc32)[C@H](O)[C@@H]1O 10.1021/jm300206u
23653582 88624 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human adenosine A3 receptor after 15 to 30 minsAntagonist activity at human adenosine A3 receptor after 15 to 30 mins
ChEMBL 494 5 4 9 0.6 OC[C@]12CN[C@H]([C@@H]1O)[C@H](n1cnc3c(NCc4cccc(I)c4)ncnc31)O2 10.1016/j.bmc.2007.05.056
CHEMBL235543 88624 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human adenosine A3 receptor after 15 to 30 minsAntagonist activity at human adenosine A3 receptor after 15 to 30 mins
ChEMBL 494 5 4 9 0.6 OC[C@]12CN[C@H]([C@@H]1O)[C@H](n1cnc3c(NCc4cccc(I)c4)ncnc31)O2 10.1016/j.bmc.2007.05.056
46238068 8737 None 0 Human Functional pIC50 = 8.1 8.1 181 2
Antagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry
ChEMBL 450 6 2 6 5.2 COc1ccc(NC(=O)Nc2nc(-c3ccccc3)nc3nn(Cc4ccccc4)cc23)cc1 10.1021/jm901785w
CHEMBL1096078 8737 None 0 Human Functional pIC50 = 8.1 8.1 181 2
Antagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated [3H]cAMP production treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry
ChEMBL 450 6 2 6 5.2 COc1ccc(NC(=O)Nc2nc(-c3ccccc3)nc3nn(Cc4ccccc4)cc23)cc1 10.1021/jm901785w
10927693 56767 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 4.4-15.2Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 4.4-15.2
ChEMBL 408 3 2 8 3.6 Cn1cc2c(nc(NC(=O)Nc3ccccc3Cl)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
CHEMBL164281 56767 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 4.4-15.2Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 4.4-15.2
ChEMBL 408 3 2 8 3.6 Cn1cc2c(nc(NC(=O)Nc3ccccc3Cl)n3nc(-c4ccco4)nc23)n1 10.1021/jm0109614
52936297 61292 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 minsAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 mins
ChEMBL 416 5 2 6 4.0 COc1ccc(OC)c(NC(=O)Nc2nn(-c3ccccc3)c(=O)c3ccccc23)c1 10.1021/jm101328n
CHEMBL1766358 61292 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 minsAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 mins
ChEMBL 416 5 2 6 4.0 COc1ccc(OC)c(NC(=O)Nc2nn(-c3ccccc3)c(=O)c3ccccc23)c1 10.1021/jm101328n
127036561 137638 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 411 5 1 6 4.7 O=C(Cc1ccccc1)Nc1nc(-c2cccs2)nc2cn(-c3ccccc3)nc12 10.1016/j.ejmech.2015.11.015
CHEMBL3754475 137638 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting methodAntagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation counting method
ChEMBL 411 5 1 6 4.7 O=C(Cc1ccccc1)Nc1nc(-c2cccs2)nc2cn(-c3ccccc3)nc12 10.1016/j.ejmech.2015.11.015
11524705 77803 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity against Cl-IB-MECA inhibited cAMP level in CHO cells transfected with human A3 receptorAntagonist activity against Cl-IB-MECA inhibited cAMP level in CHO cells transfected with human A3 receptor
ChEMBL 426 4 2 8 2.9 COc1ccc(-n2nc3c(NC(=O)c4ccccc4)nc4c(N)cccc4n3c2=O)cc1 10.1021/jm060373w
CHEMBL209122 77803 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity against Cl-IB-MECA inhibited cAMP level in CHO cells transfected with human A3 receptorAntagonist activity against Cl-IB-MECA inhibited cAMP level in CHO cells transfected with human A3 receptor
ChEMBL 426 4 2 8 2.9 COc1ccc(-n2nc3c(NC(=O)c4ccccc4)nc4c(N)cccc4n3c2=O)cc1 10.1021/jm060373w
168282045 191313 None 0 Human Functional pIC50 = 8.1 8.1 1 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 496 10 3 8 5.1 COc1cc(Nc2nc(CNCc3cccnc3)cc3c(-c4ccccc4)n[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
CHEMBL5189470 191313 None 0 Human Functional pIC50 = 8.1 8.1 1 2
Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 minsAntagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accumulation incubated for 30 mins
ChEMBL 496 10 3 8 5.1 COc1cc(Nc2nc(CNCc3cccnc3)cc3c(-c4ccccc4)n[nH]c23)cc(OC)c1OC 10.1021/acs.jmedchem.2c01123
71602202 86952 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Inhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECAInhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECA
ChEMBL 435 6 1 6 4.7 COc1ccc(-n2cc3nc(-c4ccccc4)nc(NC(=O)Cc4ccccc4)c3n2)cc1 10.1021/jm400068e
CHEMBL2322908 86952 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Inhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECAInhibition of human A3 adenosine receptor transfected in CHO cells assessed as inhibition of forskolin-induced cyclic AMP production after 10 mins by competitive protein binding assay in presence of CI-IB-MECA
ChEMBL 435 6 1 6 4.7 COc1ccc(-n2cc3nc(-c4ccccc4)nc(NC(=O)Cc4ccccc4)c3n2)cc1 10.1021/jm400068e
9935978 96930 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Inhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptorInhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptor
ChEMBL 506 6 6 11 -1.1 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NC(=O)Nc4ccc(S(N)(=O)=O)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm0408161
CHEMBL265587 96930 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Inhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptorInhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptor
ChEMBL 506 6 6 11 -1.1 CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NC(=O)Nc4ccc(S(N)(=O)=O)cc4)ncnc32)[C@H](O)[C@@H]1O 10.1021/jm0408161
10874051 84284 None 0 Human Functional pIC50 = 6.1 6.1 -46 2
Antagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECAAntagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECA
ChEMBL 450 5 2 10 3.6 COc1ccc(NC(=O)Nc2nc3nn(C)c(SC)c3c3nc(-c4ccco4)nn23)cc1 10.1021/jm021023m
CHEMBL22113 84284 None 0 Human Functional pIC50 = 6.1 6.1 -46 2
Antagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECAAntagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECA
ChEMBL 450 5 2 10 3.6 COc1ccc(NC(=O)Nc2nc3nn(C)c(SC)c3c3nc(-c4ccco4)nn23)cc1 10.1021/jm021023m
135513694 112864 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Activity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation countingActivity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation counting
ChEMBL 295 1 1 4 3.9 Oc1nc2ccccc2c2cc(-c3ccc(Cl)cc3)nn12 10.1016/j.bmc.2012.10.031
CHEMBL330664 112864 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Activity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation countingActivity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation counting
ChEMBL 295 1 1 4 3.9 Oc1nc2ccccc2c2cc(-c3ccc(Cl)cc3)nn12 10.1016/j.bmc.2012.10.031
60155797 76995 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 489 5 2 9 3.2 Cn1cc2c(nc(NC(=O)NC3CCN(Cc4ccc(F)cc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2070887 76995 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 489 5 2 9 3.2 Cn1cc2c(nc(NC(=O)NC3CCN(Cc4ccc(F)cc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
60154742 77200 None 0 Human Functional pIC50 = 7.1 7.1 39 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 501 4 3 10 2.5 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)Nc4ccncc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2071050 77200 None 0 Human Functional pIC50 = 7.1 7.1 39 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 501 4 3 10 2.5 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)Nc4ccncc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2078766 77200 None 0 Human Functional pIC50 = 7.1 7.1 39 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 501 4 3 10 2.5 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)Nc4ccncc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
44570156 177665 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay
ChEMBL 388 3 1 5 5.1 O=C(Nc1nc2ccccc2c2cn(-c3ccc(Cl)cc3)nc12)c1ccco1 10.1016/j.bmc.2008.10.018
CHEMBL464040 177665 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay
ChEMBL 388 3 1 5 5.1 O=C(Nc1nc2ccccc2c2cn(-c3ccc(Cl)cc3)nc12)c1ccco1 10.1016/j.bmc.2008.10.018
71453989 83561 None 0 Human Functional pIC50 = 6.1 6.1 1 2
Antagonist activity at adenosine A3 receptorAntagonist activity at adenosine A3 receptor
ChEMBL 298 0 0 4 4.0 Cn1c2cnc1OCC/C=C\CCCCOc1ccccc1-2 10.1021/jm1012374
CHEMBL2203622 83561 None 0 Human Functional pIC50 = 6.1 6.1 1 2
Antagonist activity at adenosine A3 receptorAntagonist activity at adenosine A3 receptor
ChEMBL 298 0 0 4 4.0 Cn1c2cnc1OCC/C=C\CCCCOc1ccccc1-2 10.1021/jm1012374
10065148 99169 None 0 Human Functional pIC50 = 6.1 6.1 -57 2
Antagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECAAntagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECA
ChEMBL 329 4 1 9 2.4 CCCSc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1C 10.1021/jm021023m
CHEMBL280888 99169 None 0 Human Functional pIC50 = 6.1 6.1 -57 2
Antagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECAAntagonist activity as inhibition of cAMP generation after agonist-modulation of Adenosine A3 receptor with 100 nM CI-IB-MECA
ChEMBL 329 4 1 9 2.4 CCCSc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1C 10.1021/jm021023m
135504122 210783 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Activity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation countingActivity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation counting
ChEMBL 275 1 1 4 3.6 Cc1ccc(-c2cc3c4ccccc4nc(O)n3n2)cc1 10.1016/j.bmc.2012.10.031
CHEMBL99193 210783 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Activity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation countingActivity at human adenosine A3 receptor transfected in CHO cells assessed as Cl-IB-MECA-inhibited cAMP accumulation by scintillation counting
ChEMBL 275 1 1 4 3.6 Cc1ccc(-c2cc3c4ccccc4nc(O)n3n2)cc1 10.1016/j.bmc.2012.10.031
24768447 97623 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as reversal of NECA-mediated inhibition of forskolin-induced cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as reversal of NECA-mediated inhibition of forskolin-induced cAMP accumulation
ChEMBL 351 7 1 5 4.2 CCCSc1nc(NC(C)=O)cc(OCc2ccc(Cl)cc2)n1 10.1021/jm701159t
CHEMBL270676 97623 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as reversal of NECA-mediated inhibition of forskolin-induced cAMP accumulationAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as reversal of NECA-mediated inhibition of forskolin-induced cAMP accumulation
ChEMBL 351 7 1 5 4.2 CCCSc1nc(NC(C)=O)cc(OCc2ccc(Cl)cc2)n1 10.1021/jm701159t
60154738 77015 None 0 Human Functional pIC50 = 7.1 7.1 5 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 548 5 3 9 3.4 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCc4ccc(Cl)cc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2071047 77015 None 0 Human Functional pIC50 = 7.1 7.1 5 2
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 548 5 3 9 3.4 Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCc4ccc(Cl)cc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
60155798 76996 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 505 5 2 9 3.7 Cn1cc2c(nc(NC(=O)NC3CCN(Cc4ccc(Cl)cc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
CHEMBL2070888 76996 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 505 5 2 9 3.7 Cn1cc2c(nc(NC(=O)NC3CCN(Cc4ccc(Cl)cc4)CC3)n3nc(-c4ccco4)nc23)n1 10.1021/jm300323t
60155713 76990 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 395 3 2 9 1.5 CN1CCC(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)CC1 10.1021/jm300323t
CHEMBL2070881 76990 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as forskolin/C1-IB-MECA-induced inhibition of cAMP production
ChEMBL 395 3 2 9 1.5 CN1CCC(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)CC1 10.1021/jm300323t
11611903 83129 None 0 Human Functional pKd = 9.8 9.8 - 1
Antagonist activity at human recombinant adenosine A3 receptor expressed in HEK293 cellsAntagonist activity at human recombinant adenosine A3 receptor expressed in HEK293 cells
ChEMBL 439 6 4 9 1.1 OC[C@H]1O[C@@H](n2cnc3c(C(F)(F)F)nc(NCCc4ccccc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300087j
CHEMBL2181968 83129 None 0 Human Functional pKd = 9.8 9.8 - 1
Antagonist activity at human recombinant adenosine A3 receptor expressed in HEK293 cellsAntagonist activity at human recombinant adenosine A3 receptor expressed in HEK293 cells
ChEMBL 439 6 4 9 1.1 OC[C@H]1O[C@@H](n2cnc3c(C(F)(F)F)nc(NCCc4ccccc4)nc32)[C@H](O)[C@@H]1O 10.1021/jm300087j
57325782 74303 None 0 Human Functional pKd = 9.5 9.5 - 0
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrsAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrs
ChEMBL 533 14 3 9 3.2 COc1ccc(-n2nc3c(NC(=O)CCC(=O)NCCCCCCCCN)nc4ccccc4n3c2=O)cc1 10.1021/jm201722y
CHEMBL2023738 74303 None 0 Human Functional pKd = 9.5 9.5 - 0
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrsAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrs
ChEMBL 533 14 3 9 3.2 COc1ccc(-n2nc3c(NC(=O)CCC(=O)NCCCCCCCCN)nc4ccccc4n3c2=O)cc1 10.1021/jm201722y
CHEMBL2024149 211592 None 0 Human Functional pKd = 9.4 9.4 - 0
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrsAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrs
ChEMBL None None None COc1ccc(-n2nc3c(NC(=O)CCC(=O)NCCOCCOCCNC(=O)CCCCCNC(=O)COc4ccc(/C=C/C5=[N+]6C(=Cc7ccc(-c8cccs8)n7[B-]6(F)F)C=C5)cc4)nc4ccccc4n3c2=O)cc1 10.1021/jm201722y
137635053 156146 None 0 Human Functional pKd = 8.9 8.9 - 0
Antagonist activity at human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]GTPgammaS binding measured after 30 minsAntagonist activity at human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]GTPgammaS binding measured after 30 mins
ChEMBL 406 6 0 8 2.3 COc1cccc(Cn2c(=O)n(CC3CC3)c(=O)c3c2nc2cc(OC)ccn23)c1 10.1021/acs.jmedchem.7b00950
CHEMBL4062581 156146 None 0 Human Functional pKd = 8.9 8.9 - 0
Antagonist activity at human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]GTPgammaS binding measured after 30 minsAntagonist activity at human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]GTPgammaS binding measured after 30 mins
ChEMBL 406 6 0 8 2.3 COc1cccc(Cn2c(=O)n(CC3CC3)c(=O)c3c2nc2cc(OC)ccn23)c1 10.1021/acs.jmedchem.7b00950
57325783 74304 None 0 Human Functional pKd = 8.8 8.8 - 0
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrsAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrs
ChEMBL 364 4 2 8 0.9 COc1ccc(-n2nc3c(NC(=O)CN)nc4ccccc4n3c2=O)cc1 10.1021/jm201722y
CHEMBL2023739 74304 None 0 Human Functional pKd = 8.8 8.8 - 0
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrsAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrs
ChEMBL 364 4 2 8 0.9 COc1ccc(-n2nc3c(NC(=O)CN)nc4ccccc4n3c2=O)cc1 10.1021/jm201722y
155529088 171505 None 0 Human Functional pKd = 5.9 5.9 - 0
Competitive surmountable antagonist activity at human A3 adenosine receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]-GTPgammaS binding preincubated for 60 mins followed by 2-Cl-IB-MECA and [35S]-GTPgammaS addition and measured after 30 minsCompetitive surmountable antagonist activity at human A3 adenosine receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]-GTPgammaS binding preincubated for 60 mins followed by 2-Cl-IB-MECA and [35S]-GTPgammaS addition and measured after 30 mins
ChEMBL 513 9 1 10 1.5 CCCn1c(=O)c2c(nc3cc(OC)ccn32)n(CCCNC(=O)c2ccc(S(C)(=O)=O)cc2)c1=O 10.1021/acs.jmedchem.8b02026
CHEMBL4462442 171505 None 0 Human Functional pKd = 5.9 5.9 - 0
Competitive surmountable antagonist activity at human A3 adenosine receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]-GTPgammaS binding preincubated for 60 mins followed by 2-Cl-IB-MECA and [35S]-GTPgammaS addition and measured after 30 minsCompetitive surmountable antagonist activity at human A3 adenosine receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]-GTPgammaS binding preincubated for 60 mins followed by 2-Cl-IB-MECA and [35S]-GTPgammaS addition and measured after 30 mins
ChEMBL 513 9 1 10 1.5 CCCn1c(=O)c2c(nc3cc(OC)ccn32)n(CCCNC(=O)c2ccc(S(C)(=O)=O)cc2)c1=O 10.1021/acs.jmedchem.8b02026
57325945 74321 None 0 Human Functional pKd = 6.8 6.8 - 0
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrsAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrs
ChEMBL 1175 27 4 17 6.6 CCN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCOCCOCCNC(=O)CCC(=O)Nc3nc4ccccc4n4c(=O)n(-c5ccc(OC)cc5)nc34)c3cc(S(=O)(=O)[O-])ccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21 10.1021/jm201722y
70692003 74321 None 0 Human Functional pKd = 6.8 6.8 - 0
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrsAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrs
ChEMBL 1175 27 4 17 6.6 CCN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCOCCOCCNC(=O)CCC(=O)Nc3nc4ccccc4n4c(=O)n(-c5ccc(OC)cc5)nc34)c3cc(S(=O)(=O)[O-])ccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21 10.1021/jm201722y
CHEMBL2024151 74321 None 0 Human Functional pKd = 6.8 6.8 - 0
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrsAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrs
ChEMBL 1175 27 4 17 6.6 CCN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCOCCOCCNC(=O)CCC(=O)Nc3nc4ccccc4n4c(=O)n(-c5ccc(OC)cc5)nc34)c3cc(S(=O)(=O)[O-])ccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21 10.1021/jm201722y
11427243 109790 None 0 Human Functional pKd = 6.8 6.8 - 0
Antagonist activity at human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]GTPgammaS binding preincubated with or without for 60 mins followed by addition of 2-Cl-IB-MECA and [35S]GTPgammaS measured after 30 minsAntagonist activity at human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]GTPgammaS binding preincubated with or without for 60 mins followed by addition of 2-Cl-IB-MECA and [35S]GTPgammaS measured after 30 mins
ChEMBL 322 3 1 6 1.4 COc1ccn2c(c1)nc1c2c(=O)[nH]c(=O)n1Cc1ccccc1 10.1021/acs.jmedchem.7b00950
CHEMBL322968 109790 None 0 Human Functional pKd = 6.8 6.8 - 0
Antagonist activity at human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]GTPgammaS binding preincubated with or without for 60 mins followed by addition of 2-Cl-IB-MECA and [35S]GTPgammaS measured after 30 minsAntagonist activity at human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]GTPgammaS binding preincubated with or without for 60 mins followed by addition of 2-Cl-IB-MECA and [35S]GTPgammaS measured after 30 mins
ChEMBL 322 3 1 6 1.4 COc1ccn2c(c1)nc1c2c(=O)[nH]c(=O)n1Cc1ccccc1 10.1021/acs.jmedchem.7b00950
21874557 3996 None 45 Human Functional pKd = 5.8 5.8 - 0
Antagonist activity at human adenosine A3 receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assayAntagonist activity at human adenosine A3 receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assay
ChEMBL 321 3 2 8 2.0 Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N 10.1021/jm800961g
5612 3996 None 45 Human Functional pKd = 5.8 5.8 - 0
Antagonist activity at human adenosine A3 receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assayAntagonist activity at human adenosine A3 receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assay
ChEMBL 321 3 2 8 2.0 Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N 10.1021/jm800961g
CHEMBL447664 3996 None 45 Human Functional pKd = 5.8 5.8 - 0
Antagonist activity at human adenosine A3 receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assayAntagonist activity at human adenosine A3 receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assay
ChEMBL 321 3 2 8 2.0 Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N 10.1021/jm800961g
DB06625 3996 None 45 Human Functional pKd = 5.8 5.8 - 0
Antagonist activity at human adenosine A3 receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assayAntagonist activity at human adenosine A3 receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assay
ChEMBL 321 3 2 8 2.0 Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N 10.1021/jm800961g
CHEMBL2024148 211591 None 0 Human Functional pKd = 7.8 7.8 - 0
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrsAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrs
ChEMBL None None None COc1ccc(-n2nc3c(NC(=O)CCC(=O)NCCCCCCCCNC(=O)CCCCCNC(=O)COc4ccc(/C=C/C5=[N+]6C(=Cc7ccc(-c8cccs8)n7[B-]6(F)F)C=C5)cc4)nc4ccccc4n3c2=O)cc1 10.1021/jm201722y
57325781 74302 None 0 Human Functional pKd = 7.7 7.7 - 0
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrsAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrs
ChEMBL 537 14 3 11 0.9 COc1ccc(-n2nc3c(NC(=O)CCC(=O)NCCOCCOCCN)nc4ccccc4n3c2=O)cc1 10.1021/jm201722y
CHEMBL2023737 74302 None 0 Human Functional pKd = 7.7 7.7 - 0
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrsAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrs
ChEMBL 537 14 3 11 0.9 COc1ccc(-n2nc3c(NC(=O)CCC(=O)NCCOCCOCCN)nc4ccccc4n3c2=O)cc1 10.1021/jm201722y
CHEMBL2024150 211593 None 0 Human Functional pKd = 8.5 8.5 - 0
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrsAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrs
ChEMBL None None None COc1ccc(-n2nc3c(NC(=O)CCC(=O)NCCOCCOCCNC(=O)CCCCCNC(=O)COc4ccc(C5=[N+]6C(=Cc7ccc(-c8cccs8)n7[B-]6(F)F)C=C5)cc4)nc4ccccc4n3c2=O)cc1 10.1021/jm201722y
CHEMBL5081913 217264 None 0 Human Functional pKd = 7.5 7.5 - 0
Antagonist activity at N-terminal NLuc tagged human A3 adenosine receptorAntagonist activity at N-terminal NLuc tagged human A3 adenosine receptor
ChEMBL None None None CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCCNC(=O)CCCCNC(=O)COc4ccc(/C=C/C5=[N+]6C(=Cc7ccc(-c8cccs8)n7[B-]6(F)F)C=C5)cc4)cc3)nc2n(CCC)c1=O 10.1021/acs.jmedchem.0c02067
57325784 74320 None 0 Human Functional pKd = 7.4 7.4 - 0
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrsAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrs
ChEMBL 426 4 2 8 2.9 COc1ccc(-n2nc3c(NC(=O)c4ccc(N)cc4)nc4ccccc4n3c2=O)cc1 10.1021/jm201722y
CHEMBL2024147 74320 None 0 Human Functional pKd = 7.4 7.4 - 0
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrsAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrs
ChEMBL 426 4 2 8 2.9 COc1ccc(-n2nc3c(NC(=O)c4ccc(N)cc4)nc4ccccc4n3c2=O)cc1 10.1021/jm201722y
155513958 169903 None 1 Human Functional pKd = 7.4 7.4 - 1
Competitive insurmountable antagonist activity at human A3 adenosine receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]-GTPgammaS binding measured after 30 minsCompetitive insurmountable antagonist activity at human A3 adenosine receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]-GTPgammaS binding measured after 30 mins
ChEMBL 517 9 1 10 1.7 CCCn1c(=O)c2c(nc3cc(OC)ccn32)n(CCCNC(=O)c2ccc(S(=O)(=O)F)cc2)c1=O 10.1021/acs.jmedchem.8b02026
CHEMBL4439336 169903 None 1 Human Functional pKd = 7.4 7.4 - 1
Competitive insurmountable antagonist activity at human A3 adenosine receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]-GTPgammaS binding measured after 30 minsCompetitive insurmountable antagonist activity at human A3 adenosine receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]-GTPgammaS binding measured after 30 mins
ChEMBL 517 9 1 10 1.7 CCCn1c(=O)c2c(nc3cc(OC)ccn32)n(CCCNC(=O)c2ccc(S(=O)(=O)F)cc2)c1=O 10.1021/acs.jmedchem.8b02026
9869857 66851 None 12 Human Functional pKd = 8.3 8.3 -1 5
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-mediated cyclic AMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-mediated cyclic AMP production
ChEMBL 482 8 5 14 -0.6 CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1 10.1021/jm300087j
CHEMBL186113 66851 None 12 Human Functional pKd = 8.3 8.3 -1 5
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-mediated cyclic AMP productionAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-mediated cyclic AMP production
ChEMBL 482 8 5 14 -0.6 CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1 10.1021/jm300087j
57326041 74322 None 0 Human Functional pKd = 8.3 8.3 - 0
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrsAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrs
ChEMBL 1549 58 4 28 3.0 COc1ccc(-n2nc3c(NC(=O)CCC(=O)NCCOCCOCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)c4ccc(-c5c6ccc(=[N+](C)C)cc-6oc6cc(N(C)C)ccc56)c(C(=O)[O-])c4)nc4ccccc4n3c2=O)cc1 10.1021/jm201722y
CHEMBL2024152 74322 None 0 Human Functional pKd = 8.3 8.3 - 0
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrsAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NECA-induced CRE-SPAP gene transcription by measuring intracellular cAMP level after 5 hrs
ChEMBL 1549 58 4 28 3.0 COc1ccc(-n2nc3c(NC(=O)CCC(=O)NCCOCCOCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)c4ccc(-c5c6ccc(=[N+](C)C)cc-6oc6cc(N(C)C)ccc56)c(C(=O)[O-])c4)nc4ccccc4n3c2=O)cc1 10.1021/jm201722y
CHEMBL5092175 217839 None 0 Human Functional pKd = 8.2 8.2 - 0
Antagonist activity at N-terminal NLuc tagged human A3 adenosine receptorAntagonist activity at N-terminal NLuc tagged human A3 adenosine receptor
ChEMBL None None None CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCCNC(=O)CCNC(=O)CCCCNC(=O)CCCCNC(=O)COc4ccc(/C=C/C5=[N+]6C(=Cc7ccc(-c8cccs8)n7[B-]6(F)F)C=C5)cc4)cc3)nc2n(CCC)c1=O 10.1021/acs.jmedchem.0c02067
11427243 109790 None 0 Human Functional pKd = 7.2 7.2 - 0
Antagonist activity at human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]GTPgammaS binding measured after 30 minsAntagonist activity at human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]GTPgammaS binding measured after 30 mins
ChEMBL 322 3 1 6 1.4 COc1ccn2c(c1)nc1c2c(=O)[nH]c(=O)n1Cc1ccccc1 10.1021/acs.jmedchem.7b00950
CHEMBL322968 109790 None 0 Human Functional pKd = 7.2 7.2 - 0
Antagonist activity at human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]GTPgammaS binding measured after 30 minsAntagonist activity at human adenosine A3 receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]GTPgammaS binding measured after 30 mins
ChEMBL 322 3 1 6 1.4 COc1ccn2c(c1)nc1c2c(=O)[nH]c(=O)n1Cc1ccccc1 10.1021/acs.jmedchem.7b00950
155529088 171505 None 0 Human Functional pKd = 6.2 6.2 - 0
Competitive surmountable antagonist activity at human A3 adenosine receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]-GTPgammaS binding measured after 30 minsCompetitive surmountable antagonist activity at human A3 adenosine receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]-GTPgammaS binding measured after 30 mins
ChEMBL 513 9 1 10 1.5 CCCn1c(=O)c2c(nc3cc(OC)ccn32)n(CCCNC(=O)c2ccc(S(C)(=O)=O)cc2)c1=O 10.1021/acs.jmedchem.8b02026
CHEMBL4462442 171505 None 0 Human Functional pKd = 6.2 6.2 - 0
Competitive surmountable antagonist activity at human A3 adenosine receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]-GTPgammaS binding measured after 30 minsCompetitive surmountable antagonist activity at human A3 adenosine receptor expressed in CHO cell membranes assessed as inhibition of 2-Cl-IB-MECA-induced [35S]-GTPgammaS binding measured after 30 mins
ChEMBL 513 9 1 10 1.5 CCCn1c(=O)c2c(nc3cc(OC)ccn32)n(CCCNC(=O)c2ccc(S(C)(=O)=O)cc2)c1=O 10.1021/acs.jmedchem.8b02026
54587496 61708 None 0 Human Functional pKi = 11 11.0 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 376 3 2 8 1.3 Cn1cc2c(nc(NC(=O)N[n+]3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL1771603 61708 None 0 Human Functional pKi = 11 11.0 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 376 3 2 8 1.3 Cn1cc2c(nc(NC(=O)N[n+]3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
11761221 58174 None 0 Human Functional pKi = 9.8 9.8 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 402 5 2 8 3.8 CCCn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL168018 58174 None 0 Human Functional pKi = 9.8 9.8 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 402 5 2 8 3.8 CCCn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
9929470 110536 None 0 Human Functional pKi = 9.8 9.8 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 374 3 2 8 2.9 Cn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL324735 110536 None 0 Human Functional pKi = 9.8 9.8 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 374 3 2 8 2.9 Cn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
11728808 120377 None 0 Human Functional pKi = 9.7 9.7 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 388 4 2 8 3.4 CCn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL352796 120377 None 0 Human Functional pKi = 9.7 9.7 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 388 4 2 8 3.4 CCn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
9801343 112487 None 0 Human Functional pKi = 9.7 9.7 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 404 4 2 9 2.9 COc1ccc(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1 10.1016/j.bmcl.2011.03.073
CHEMBL329791 112487 None 0 Human Functional pKi = 9.7 9.7 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 404 4 2 9 2.9 COc1ccc(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1 10.1016/j.bmcl.2011.03.073
10905799 119974 None 0 Human Functional pKi = 9.7 9.7 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 416 6 2 8 4.2 CCCCn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL349240 119974 None 0 Human Functional pKi = 9.7 9.7 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 416 6 2 8 4.2 CCCCn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
10884265 57426 None 0 Human Functional pKi = 9.6 9.6 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 418 3 2 10 2.6 Cn1cc2c(nc(NC(=O)Nc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL165224 57426 None 0 Human Functional pKi = 9.6 9.6 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 418 3 2 10 2.6 Cn1cc2c(nc(NC(=O)Nc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
11112849 57320 None 0 Human Functional pKi = 9.6 9.6 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 432 4 2 10 3.1 CCn1cc2c(nc(NC(=O)Nc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL165083 57320 None 0 Human Functional pKi = 9.6 9.6 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 432 4 2 10 3.1 CCn1cc2c(nc(NC(=O)Nc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
10939224 57553 None 0 Human Functional pKi = 9.5 9.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 446 5 2 10 3.5 CCCn1cc2c(nc(NC(=O)Nc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL166301 57553 None 0 Human Functional pKi = 9.5 9.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 446 5 2 10 3.5 CCCn1cc2c(nc(NC(=O)Nc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
10623248 112703 None 0 Human Functional pKi = 9.5 9.5 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 446 7 2 9 4.2 CCCCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL330286 112703 None 0 Human Functional pKi = 9.5 9.5 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 446 7 2 9 4.2 CCCCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
11037972 57473 None 0 Human Functional pKi = 9.4 9.4 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 466 4 2 8 4.2 CCn1cc2c(nc(NC(=O)Nc3ccc(Br)cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL165600 57473 None 0 Human Functional pKi = 9.4 9.4 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 466 4 2 8 4.2 CCn1cc2c(nc(NC(=O)Nc3ccc(Br)cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
9822747 119445 None 0 Human Functional pKi = 9.4 9.4 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 408 3 2 8 3.6 Cn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL344501 119445 None 0 Human Functional pKi = 9.4 9.4 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 408 3 2 8 3.6 Cn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
11133545 120534 None 0 Human Functional pKi = 9.4 9.4 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 419 4 2 10 2.8 Cn1cc2c(nc(NC(=O)Nc3ccc([N+](=O)[O-])cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL354161 120534 None 0 Human Functional pKi = 9.4 9.4 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 419 4 2 10 2.8 Cn1cc2c(nc(NC(=O)Nc3ccc([N+](=O)[O-])cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
135401232 3206 None 4 Human Functional pKi = 9.4 9.4 - 1
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 397 2 1 3 4.4 CC[C@H]1N=c2n(C1)c(=O)n(c1c2[nH]c(n1)c1cc(Cl)cc(c1Cl)Cl)C 10.1016/j.ejmech.2021.113907
5619 3206 None 4 Human Functional pKi = 9.4 9.4 - 1
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 397 2 1 3 4.4 CC[C@H]1N=c2n(C1)c(=O)n(c1c2[nH]c(n1)c1cc(Cl)cc(c1Cl)Cl)C 10.1016/j.ejmech.2021.113907
CHEMBL1562432 3206 None 4 Human Functional pKi = 9.4 9.4 - 1
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 397 2 1 3 4.4 CC[C@H]1N=c2n(C1)c(=O)n(c1c2[nH]c(n1)c1cc(Cl)cc(c1Cl)Cl)C 10.1016/j.ejmech.2021.113907
11733556 120081 None 0 Human Functional pKi = 9.4 9.4 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 480 5 2 8 4.6 CCCn1cc2c(nc(NC(=O)Nc3ccc(Br)cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL350205 120081 None 0 Human Functional pKi = 9.4 9.4 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 480 5 2 8 4.6 CCCn1cc2c(nc(NC(=O)Nc3ccc(Br)cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
11144868 119936 None 0 Human Functional pKi = 9.3 9.3 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 452 3 2 8 3.7 Cn1cc2c(nc(NC(=O)Nc3ccc(Br)cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL348925 119936 None 0 Human Functional pKi = 9.3 9.3 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 452 3 2 8 3.7 Cn1cc2c(nc(NC(=O)Nc3ccc(Br)cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
10994183 120296 None 0 Human Functional pKi = 9.3 9.3 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 460 6 2 10 3.9 CCCCn1cc2c(nc(NC(=O)Nc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL352192 120296 None 0 Human Functional pKi = 9.3 9.3 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 460 6 2 10 3.9 CCCCn1cc2c(nc(NC(=O)Nc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
10928649 58163 None 0 Human Functional pKi = 9.3 9.3 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 461 7 2 10 4.1 CCCCn1cc2c(nc(NC(=O)Nc3ccc([N+](=O)[O-])cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL167915 58163 None 0 Human Functional pKi = 9.3 9.3 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 461 7 2 10 4.1 CCCCn1cc2c(nc(NC(=O)Nc3ccc([N+](=O)[O-])cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
10647227 165549 None 0 Human Functional pKi = 9.2 9.2 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 450 6 2 8 4.8 CCCCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL423934 165549 None 0 Human Functional pKi = 9.2 9.2 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 450 6 2 8 4.8 CCCCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
9953799 205832 None 2 Human Functional pKi = 9.2 9.2 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 418 5 2 9 3.4 CCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL65271 205832 None 2 Human Functional pKi = 9.2 9.2 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 418 5 2 9 3.4 CCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
393595 2637 None 36 Human Functional pKi = 9.2 9.2 16 3
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 403 4 1 6 4.4 O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1 10.1016/j.bmcl.2011.03.073
448 2637 None 36 Human Functional pKi = 9.2 9.2 16 3
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 403 4 1 6 4.4 O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1 10.1016/j.bmcl.2011.03.073
CHEMBL88147 2637 None 36 Human Functional pKi = 9.2 9.2 16 3
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 403 4 1 6 4.4 O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1 10.1016/j.bmcl.2011.03.073
11026434 57509 None 0 Human Functional pKi = 9.2 9.2 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 433 5 2 10 3.3 CCn1cc2c(nc(NC(=O)Nc3ccc([N+](=O)[O-])cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL165910 57509 None 0 Human Functional pKi = 9.2 9.2 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 433 5 2 10 3.3 CCn1cc2c(nc(NC(=O)Nc3ccc([N+](=O)[O-])cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
11014188 118547 None 0 Human Functional pKi = 9.1 9.1 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 373 4 1 8 2.5 Cn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL341376 118547 None 0 Human Functional pKi = 9.1 9.1 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 373 4 1 8 2.5 Cn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
10884803 120847 None 0 Human Functional pKi = 9.1 9.1 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 447 6 2 10 3.7 CCCn1cc2c(nc(NC(=O)Nc3ccc([N+](=O)[O-])cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL355415 120847 None 0 Human Functional pKi = 9.1 9.1 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 447 6 2 10 3.7 CCCn1cc2c(nc(NC(=O)Nc3ccc([N+](=O)[O-])cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
9910926 29339 None 0 Human Functional pKi = 9.0 9.0 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 436 5 2 8 4.4 CCCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL138332 29339 None 0 Human Functional pKi = 9.0 9.0 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 436 5 2 8 4.4 CCCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
10918042 120148 None 0 Human Functional pKi = 9.0 9.0 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 494 6 2 8 4.9 CCCCn1cc2c(nc(NC(=O)Nc3ccc(Br)cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL350830 120148 None 0 Human Functional pKi = 9.0 9.0 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 494 6 2 8 4.9 CCCCn1cc2c(nc(NC(=O)Nc3ccc(Br)cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
11784369 119989 None 0 Human Functional pKi = 9 9.0 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 401 6 1 8 3.3 CCCn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL349464 119989 None 0 Human Functional pKi = 9 9.0 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 401 6 1 8 3.3 CCCn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
10971099 57316 None 0 Human Functional pKi = 9.0 9.0 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 387 5 1 8 2.9 CCn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL165073 57316 None 0 Human Functional pKi = 9.0 9.0 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 387 5 1 8 2.9 CCn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
11811761 56566 None 0 Human Functional pKi = 9.0 9.0 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 415 7 1 8 3.7 CCCCn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL163968 56566 None 0 Human Functional pKi = 9.0 9.0 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 415 7 1 8 3.7 CCCCn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
10619822 57197 None 0 Human Functional pKi = 8.8 8.8 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 381 3 1 6 3.3 O=C(Nc1nc2ccccc2n2c(=O)n(-c3ccccc3)nc12)c1ccccc1 10.1016/j.bmcl.2011.03.073
CHEMBL16488 57197 None 0 Human Functional pKi = 8.8 8.8 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 381 3 1 6 3.3 O=C(Nc1nc2ccccc2n2c(=O)n(-c3ccccc3)nc12)c1ccccc1 10.1016/j.bmcl.2011.03.073
9910158 32458 None 0 Human Functional pKi = 8.8 8.8 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 422 4 2 8 4.1 CCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL141154 32458 None 0 Human Functional pKi = 8.8 8.8 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 422 4 2 8 4.1 CCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
11531978 79777 None 0 Human Functional pKi = 7 7.0 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 426 4 1 8 3.2 O=C(Nc1nc2ccccc2n2c(=O)n(-c3ccc([N+](=O)[O-])cc3)nc12)c1ccccc1 10.1016/j.bmcl.2011.03.073
CHEMBL211713 79777 None 0 Human Functional pKi = 7 7.0 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 426 4 1 8 3.2 O=C(Nc1nc2ccccc2n2c(=O)n(-c3ccc([N+](=O)[O-])cc3)nc12)c1ccccc1 10.1016/j.bmcl.2011.03.073
10267860 176928 None 0 Human Functional pKi = 6.0 6.0 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 317 3 1 8 2.0 N#Cc1ccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)cc1 10.1016/j.ejmech.2010.04.039
CHEMBL461007 176928 None 0 Human Functional pKi = 6.0 6.0 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 317 3 1 8 2.0 N#Cc1ccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)cc1 10.1016/j.ejmech.2010.04.039
CHEMBL5080823 217195 None 0 Human Functional pKi = 8.0 8.0 - 0
Antagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay
ChEMBL None None None CCCn1c(=O)c2nc(C34CCC(C(=O)NCCCN=[N+]=[N-])(CC3)CC4)[nH]c2n(CCCNC(=O)c2ccc(S(=O)(=O)F)cc2)c1=O 10.1021/acs.jmedchem.0c02169
11762982 26213 None 0 Human Functional pKi = 6.9 6.9 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 513 7 1 8 5.3 O=C(Cc1cccc2ccccc12)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL135719 26213 None 0 Human Functional pKi = 6.9 6.9 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 513 7 1 8 5.3 O=C(Cc1cccc2ccccc12)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
9892149 59644 None 0 Human Functional pKi = 6.9 6.9 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 499 9 2 7 4.2 CCCn1c(=O)c2nc(-c3ccc(/C=C/C(=O)Nc4ccccc4C(C)=O)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
CHEMBL17202 59644 None 0 Human Functional pKi = 6.9 6.9 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 499 9 2 7 4.2 CCCn1c(=O)c2nc(-c3ccc(/C=C/C(=O)Nc4ccccc4C(C)=O)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
11733496 24913 None 0 Human Functional pKi = 6.9 6.9 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 477 8 1 8 4.5 O=C(Cc1ccccc1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL134566 24913 None 0 Human Functional pKi = 6.9 6.9 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 477 8 1 8 4.5 O=C(Cc1ccccc1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
11801496 98800 None 0 Human Functional pKi = 5.9 5.9 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 587 9 2 7 4.0 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(I)cc4)cc3)[nH]c2n(CCC)c1=O 10.1016/j.ejmech.2010.04.039
CHEMBL278039 98800 None 0 Human Functional pKi = 5.9 5.9 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 587 9 2 7 4.0 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(I)cc4)cc3)[nH]c2n(CCC)c1=O 10.1016/j.ejmech.2010.04.039
11801496 98800 None 0 Human Functional pKi = 5.9 5.9 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 587 9 2 7 4.0 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(I)cc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
CHEMBL278039 98800 None 0 Human Functional pKi = 5.9 5.9 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 587 9 2 7 4.0 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(I)cc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
2690 903 None 44 Human Functional pKi = 7.9 7.9 -123 5
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 285 1 1 6 2.8 Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1 10.1016/j.bmcl.2011.03.073
384 903 None 44 Human Functional pKi = 7.9 7.9 -123 5
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 285 1 1 6 2.8 Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1 10.1016/j.bmcl.2011.03.073
CHEMBL16687 903 None 44 Human Functional pKi = 7.9 7.9 -123 5
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 285 1 1 6 2.8 Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1 10.1016/j.bmcl.2011.03.073
2519 779 None 49 Human Functional pKi = 4.9 4.9 -21877 8
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 194 0 0 6 -1.0 Cn1cnc2c1c(=O)n(C)c(=O)n2C 10.1016/j.ejmech.2021.113907
2519.0 779 None 49 Human Functional pKi = 4.9 4.9 -21877 8
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 194 0 0 6 -1.0 Cn1cnc2c1c(=O)n(C)c(=O)n2C 10.1016/j.ejmech.2021.113907
407 779 None 49 Human Functional pKi = 4.9 4.9 -21877 8
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 194 0 0 6 -1.0 Cn1cnc2c1c(=O)n(C)c(=O)n2C 10.1016/j.ejmech.2021.113907
463 779 None 49 Human Functional pKi = 4.9 4.9 -21877 8
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 194 0 0 6 -1.0 Cn1cnc2c1c(=O)n(C)c(=O)n2C 10.1016/j.ejmech.2021.113907
CHEMBL113 779 None 49 Human Functional pKi = 4.9 4.9 -21877 8
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 194 0 0 6 -1.0 Cn1cnc2c1c(=O)n(C)c(=O)n2C 10.1016/j.ejmech.2021.113907
DB00201 779 None 49 Human Functional pKi = 4.9 4.9 -21877 8
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 194 0 0 6 -1.0 Cn1cnc2c1c(=O)n(C)c(=O)n2C 10.1016/j.ejmech.2021.113907
9825550 57609 None 0 Human Functional pKi = 6.9 6.9 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 461 9 2 7 3.4 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccccc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
CHEMBL16677 57609 None 0 Human Functional pKi = 6.9 6.9 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 461 9 2 7 3.4 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccccc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
10839296 58160 None 1 Human Functional pKi = 6.9 6.9 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 506 10 2 9 3.3 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc([N+](=O)[O-])cc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
CHEMBL16787 58160 None 1 Human Functional pKi = 6.9 6.9 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 506 10 2 9 3.3 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc([N+](=O)[O-])cc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
10544617 98266 None 0 Human Functional pKi = 7.8 7.8 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 333 3 1 6 2.4 CCC(=O)Nc1nc2ccccc2n2c(=O)n(-c3ccccc3)nc12 10.1016/j.bmcl.2011.03.073
CHEMBL274273 98266 None 0 Human Functional pKi = 7.8 7.8 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 333 3 1 6 2.4 CCC(=O)Nc1nc2ccccc2n2c(=O)n(-c3ccccc3)nc12 10.1016/j.bmcl.2011.03.073
44572355 179690 None 0 Human Functional pKi = 4.8 4.8 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 269 2 1 5 1.8 CC(C)Cn1c(Br)nc2c(N)ncnc21 10.1016/j.ejmech.2010.04.039
CHEMBL474207 179690 None 0 Human Functional pKi = 4.8 4.8 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 269 2 1 5 1.8 CC(C)Cn1c(Br)nc2c(N)ncnc21 10.1016/j.ejmech.2010.04.039
443 755 None 9 Rat Functional pKi = 4.8 4.8 - 0
Antagonist activity against rat adenosine A3 receptor using [125I]I-AB-MECA or [125 I]IABAAntagonist activity against rat adenosine A3 receptor using [125I]I-AB-MECA or [125 I]IABA
ChEMBL 382 7 2 6 2.5 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)/C=C/C(=O)O 10.1021/jm990421v
6439089 755 None 9 Rat Functional pKi = 4.8 4.8 - 0
Antagonist activity against rat adenosine A3 receptor using [125I]I-AB-MECA or [125 I]IABAAntagonist activity against rat adenosine A3 receptor using [125I]I-AB-MECA or [125 I]IABA
ChEMBL 382 7 2 6 2.5 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)/C=C/C(=O)O 10.1021/jm990421v
CHEMBL16997 755 None 9 Rat Functional pKi = 4.8 4.8 - 0
Antagonist activity against rat adenosine A3 receptor using [125I]I-AB-MECA or [125 I]IABAAntagonist activity against rat adenosine A3 receptor using [125I]I-AB-MECA or [125 I]IABA
ChEMBL 382 7 2 6 2.5 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)/C=C/C(=O)O 10.1021/jm990421v
10613770 57573 None 0 Human Functional pKi = 6.8 6.8 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 295 1 1 6 1.8 Nc1nc2ccccc2n2c(=O)n(-c3cccc(F)c3)nc12 10.1016/j.bmcl.2011.03.073
CHEMBL16643 57573 None 0 Human Functional pKi = 6.8 6.8 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 295 1 1 6 1.8 Nc1nc2ccccc2n2c(=O)n(-c3cccc(F)c3)nc12 10.1016/j.bmcl.2011.03.073
42626000 180322 None 0 Human Functional pKi = 6.8 6.8 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 308 2 1 8 1.0 COc1ccc(-n2nc3c(N)nc4ncccc4n3c2=O)cc1 10.1016/j.bmcl.2011.03.073
CHEMBL474977 180322 None 0 Human Functional pKi = 6.8 6.8 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 308 2 1 8 1.0 COc1ccc(-n2nc3c(N)nc4ncccc4n3c2=O)cc1 10.1016/j.bmcl.2011.03.073
44388205 11744 None 0 Human Functional pKi = 6.8 6.8 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 402 6 2 9 1.9 NCC(=O)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL1181535 11744 None 0 Human Functional pKi = 6.8 6.8 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 402 6 2 9 1.9 NCC(=O)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL176010 11744 None 0 Human Functional pKi = 6.8 6.8 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 402 6 2 9 1.9 NCC(=O)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
10067267 58147 None 0 Human Functional pKi = 6.8 6.8 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 363 3 1 6 3.5 O=c1n(-c2cccc(F)c2)nc2c(NC3CCCC3)nc3ccccc3n12 10.1016/j.bmcl.2011.03.073
CHEMBL16774 58147 None 0 Human Functional pKi = 6.8 6.8 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 363 3 1 6 3.5 O=c1n(-c2cccc(F)c2)nc2c(NC3CCCC3)nc3ccccc3n12 10.1016/j.bmcl.2011.03.073
3661570 2641 None 42 Human Functional pKi = 7.7 7.7 - 3
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 399 9 0 5 5.7 CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(nc1c1ccccc1)CC 10.1016/j.ejmech.2021.113907
474 2641 None 42 Human Functional pKi = 7.7 7.7 - 3
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 399 9 0 5 5.7 CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(nc1c1ccccc1)CC 10.1016/j.ejmech.2021.113907
CHEMBL111545 2641 None 42 Human Functional pKi = 7.7 7.7 - 3
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 399 9 0 5 5.7 CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(nc1c1ccccc1)CC 10.1016/j.ejmech.2021.113907
10720065 98450 None 0 Human Functional pKi = 5.7 5.7 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 495 9 2 7 4.0 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(Cl)cc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
CHEMBL275427 98450 None 0 Human Functional pKi = 5.7 5.7 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 495 9 2 7 4.0 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(Cl)cc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
10338801 109797 None 0 Human Functional pKi = 8.7 8.7 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 364 3 1 4 4.8 O=C(Nc1nc2ccccc2c2cn(-c3ccccc3)nc12)c1ccccc1 10.1016/j.bmcl.2011.03.073
CHEMBL322983 109797 None 0 Human Functional pKi = 8.7 8.7 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 364 3 1 4 4.8 O=C(Nc1nc2ccccc2c2cn(-c3ccccc3)nc12)c1ccccc1 10.1016/j.bmcl.2011.03.073
135433658 3207 None 2 Human Functional pKi = 8.6 8.6 - 0
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 295 2 1 3 2.5 CC[C@@H]1Cn2c(=N1)c1[nH]c(nc1n(c2=O)C)c1ccccc1 10.1016/j.ejmech.2021.113907
5620 3207 None 2 Human Functional pKi = 8.6 8.6 - 0
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 295 2 1 3 2.5 CC[C@@H]1Cn2c(=N1)c1[nH]c(nc1n(c2=O)C)c1ccccc1 10.1016/j.ejmech.2021.113907
9882625 3207 None 2 Human Functional pKi = 8.6 8.6 - 0
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 295 2 1 3 2.5 CC[C@@H]1Cn2c(=N1)c1[nH]c(nc1n(c2=O)C)c1ccccc1 10.1016/j.ejmech.2021.113907
CHEMBL1625681 3207 None 2 Human Functional pKi = 8.6 8.6 - 0
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 295 2 1 3 2.5 CC[C@@H]1Cn2c(=N1)c1[nH]c(nc1n(c2=O)C)c1ccccc1 10.1016/j.ejmech.2021.113907
11081189 120439 None 0 Human Functional pKi = 8.6 8.6 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 470 5 2 8 5.1 CCCn1cc2c(nc(NC(=O)Nc3ccc(Cl)c(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL353299 120439 None 0 Human Functional pKi = 8.6 8.6 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 470 5 2 8 5.1 CCCn1cc2c(nc(NC(=O)Nc3ccc(Cl)c(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
11560605 78076 None 0 Human Functional pKi = 8.5 8.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 411 4 1 7 3.3 COc1ccc(-n2nc3c(NC(=O)c4ccccc4)nc4ccccc4n3c2=O)cc1 10.1016/j.bmcl.2011.03.073
CHEMBL209943 78076 None 0 Human Functional pKi = 8.5 8.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 411 4 1 7 3.3 COc1ccc(-n2nc3c(NC(=O)c4ccccc4)nc4ccccc4n3c2=O)cc1 10.1016/j.bmcl.2011.03.073
25188209 178864 None 0 Human Functional pKi = 5.7 5.7 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 311 3 1 8 1.6 Nc1nc(-c2ncco2)c2nnn(Cc3ccccc3F)c2n1 10.1016/j.ejmech.2010.04.039
CHEMBL468701 178864 None 0 Human Functional pKi = 5.7 5.7 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 311 3 1 8 1.6 Nc1nc(-c2ncco2)c2nnn(Cc3ccccc3F)c2n1 10.1016/j.ejmech.2010.04.039
10792296 98719 None 0 Human Functional pKi = 6.7 6.7 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 529 9 2 7 4.4 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C(F)(F)F)cc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
CHEMBL277386 98719 None 0 Human Functional pKi = 6.7 6.7 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 529 9 2 7 4.4 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C(F)(F)F)cc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
2153 3800 None 72 Human Functional pKi = 4.7 4.7 -4 5
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 180 0 1 5 -1.0 Cn1c(=O)n(C)c2c(c1=O)[nH]cn2 10.1016/j.ejmech.2021.113907
2153.0 3800 None 72 Human Functional pKi = 4.7 4.7 -4 5
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 180 0 1 5 -1.0 Cn1c(=O)n(C)c2c(c1=O)[nH]cn2 10.1016/j.ejmech.2021.113907
2620 3800 None 72 Human Functional pKi = 4.7 4.7 -4 5
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 180 0 1 5 -1.0 Cn1c(=O)n(C)c2c(c1=O)[nH]cn2 10.1016/j.ejmech.2021.113907
413 3800 None 72 Human Functional pKi = 4.7 4.7 -4 5
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 180 0 1 5 -1.0 Cn1c(=O)n(C)c2c(c1=O)[nH]cn2 10.1016/j.ejmech.2021.113907
CHEMBL190 3800 None 72 Human Functional pKi = 4.7 4.7 -4 5
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 180 0 1 5 -1.0 Cn1c(=O)n(C)c2c(c1=O)[nH]cn2 10.1016/j.ejmech.2021.113907
DB00277 3800 None 72 Human Functional pKi = 4.7 4.7 -4 5
Antagonist activity at adenosine A3 receptor (unknown origin)Antagonist activity at adenosine A3 receptor (unknown origin)
ChEMBL 180 0 1 5 -1.0 Cn1c(=O)n(C)c2c(c1=O)[nH]cn2 10.1016/j.ejmech.2021.113907
14484978 97645 None 0 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 483 9 1 10 1.4 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)ON4C(=O)CCC4=O)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
CHEMBL27081 97645 None 0 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 483 9 1 10 1.4 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)ON4C(=O)CCC4=O)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
3287 2642 None 33 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 503 10 2 8 3.6 CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C(=O)C 10.1016/j.ejmech.2010.04.039
5139184 2642 None 33 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 503 10 2 8 3.6 CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C(=O)C 10.1016/j.ejmech.2010.04.039
CHEMBL17002 2642 None 33 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 503 10 2 8 3.6 CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C(=O)C 10.1016/j.ejmech.2010.04.039
3287 2642 None 33 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 503 10 2 8 3.6 CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C(=O)C 10.1021/jm990421v
5139184 2642 None 33 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 503 10 2 8 3.6 CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C(=O)C 10.1021/jm990421v
CHEMBL17002 2642 None 33 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 503 10 2 8 3.6 CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C(=O)C 10.1021/jm990421v
10840167 59196 None 0 Human Functional pKi = 5.6 5.6 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 539 9 2 7 4.2 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
CHEMBL17003 59196 None 0 Human Functional pKi = 5.6 5.6 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 539 9 2 7 4.2 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
135911553 201352 None 0 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation countingAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation counting
ChEMBL 240 2 1 4 1.7 CCc1nc2cn(-c3ccccc3)nc2c(=O)[nH]1 10.1021/jm900718w
CHEMBL584382 201352 None 0 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation countingAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation counting
ChEMBL 240 2 1 4 1.7 CCc1nc2cn(-c3ccccc3)nc2c(=O)[nH]1 10.1021/jm900718w
9803992 110487 None 0 Human Functional pKi = 7.6 7.6 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 454 4 3 10 2.2 Cn1cc2c(nc(NC(=O)Nc3ccc(S(=O)(=O)O)cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL324512 110487 None 0 Human Functional pKi = 7.6 7.6 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 454 4 3 10 2.2 Cn1cc2c(nc(NC(=O)Nc3ccc(S(=O)(=O)O)cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
404 4098 None 26 Human Functional pKi = 7.6 7.6 - 2
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 428 10 3 8 0.8 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN 10.1021/jm990421v
432 4098 None 26 Human Functional pKi = 7.6 7.6 - 2
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 428 10 3 8 0.8 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN 10.1021/jm990421v
5697 4098 None 26 Human Functional pKi = 7.6 7.6 - 2
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 428 10 3 8 0.8 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN 10.1021/jm990421v
CHEMBL273094 4098 None 26 Human Functional pKi = 7.6 7.6 - 2
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 428 10 3 8 0.8 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN 10.1021/jm990421v
10451086 98585 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 359 3 1 6 3.7 Cc1cccc(-n2nc3c(NC4CCCC4)nc4ccccc4n3c2=O)c1 10.1016/j.bmcl.2011.03.073
CHEMBL276321 98585 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 359 3 1 6 3.7 Cc1cccc(-n2nc3c(NC4CCCC4)nc4ccccc4n3c2=O)c1 10.1016/j.bmcl.2011.03.073
135911556 201353 None 0 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation countingAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation counting
ChEMBL 242 2 1 5 1.1 COc1ccc(-n2cc3nc[nH]c(=O)c3n2)cc1 10.1021/jm900718w
CHEMBL584383 201353 None 0 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation countingAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation counting
ChEMBL 242 2 1 5 1.1 COc1ccc(-n2cc3nc[nH]c(=O)c3n2)cc1 10.1021/jm900718w
10387088 59474 None 0 Rat Functional pKi = 5.6 5.6 - 0
Antagonist activity against rat adenosine A3 receptor using [125I]I-AB-MECA or [125 I]IABAAntagonist activity against rat adenosine A3 receptor using [125I]I-AB-MECA or [125 I]IABA
ChEMBL 414 10 2 7 2.6 CCCCn1c(=O)c2nc(-c3ccc(OCC(=O)O)cc3)[nH]c2n(CCCC)c1=O 10.1021/jm990421v
CHEMBL17123 59474 None 0 Rat Functional pKi = 5.6 5.6 - 0
Antagonist activity against rat adenosine A3 receptor using [125I]I-AB-MECA or [125 I]IABAAntagonist activity against rat adenosine A3 receptor using [125I]I-AB-MECA or [125 I]IABA
ChEMBL 414 10 2 7 2.6 CCCCn1c(=O)c2nc(-c3ccc(OCC(=O)O)cc3)[nH]c2n(CCCC)c1=O 10.1021/jm990421v
10834552 56120 None 0 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 396 3 2 6 3.7 O=C(Nc1ccccc1)Nc1nc2ccccc2n2c(=O)n(-c3ccccc3)nc12 10.1016/j.bmcl.2011.03.073
CHEMBL16254 56120 None 0 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 396 3 2 6 3.7 O=C(Nc1ccccc1)Nc1nc2ccccc2n2c(=O)n(-c3ccccc3)nc12 10.1016/j.bmcl.2011.03.073
10541585 162475 None 0 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 291 1 1 6 1.9 Cc1cccc(-n2nc3c(N)nc4ccccc4n3c2=O)c1 10.1016/j.bmcl.2011.03.073
CHEMBL416537 162475 None 0 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 291 1 1 6 1.9 Cc1cccc(-n2nc3c(N)nc4ccccc4n3c2=O)c1 10.1016/j.bmcl.2011.03.073
10246959 58781 None 0 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 345 4 1 8 2.6 Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL16867 58781 None 0 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 345 4 1 8 2.6 Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
49863226 15224 None 0 Human Functional pKi = 5.6 5.6 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 311 3 1 9 0.6 Nc1nc(-n2cncn2)c2nnn(Cc3ccccc3F)c2n1 10.1016/j.ejmech.2010.04.039
CHEMBL1210734 15224 None 0 Human Functional pKi = 5.6 5.6 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 311 3 1 9 0.6 Nc1nc(-n2cncn2)c2nnn(Cc3ccccc3F)c2n1 10.1016/j.ejmech.2010.04.039
9850900 98404 None 0 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 565 12 1 7 5.0 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)N(Cc4ccccc4)Cc4ccccc4)cc3)[nH]c2n(CCC)c1=O 10.1016/j.ejmech.2010.04.039
CHEMBL275149 98404 None 0 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 565 12 1 7 5.0 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)N(Cc4ccccc4)Cc4ccccc4)cc3)[nH]c2n(CCC)c1=O 10.1016/j.ejmech.2010.04.039
9850900 98404 None 0 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 565 12 1 7 5.0 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)N(Cc4ccccc4)Cc4ccccc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
CHEMBL275149 98404 None 0 Human Functional pKi = 6.6 6.6 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 565 12 1 7 5.0 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)N(Cc4ccccc4)Cc4ccccc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
CHEMBL5076192 216907 None 0 Human Functional pKi = 8.5 8.5 - 0
Antagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay
ChEMBL None None None CCCCn1c(=O)c2nc(C34CCC(C(=O)NCCCCCCCCN=[N+]=[N-])(CC3)CC4)[nH]c2n(CCCNC(=O)c2ccc(S(=O)(=O)F)cc2)c1=O 10.1021/acs.jmedchem.0c02169
10045876 2634 None 16 Human Functional pKi = 8.5 8.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 389 3 1 6 4.4 Clc1ccc2c(c1)c1nc(nn1c(n2)NC(=O)c1ccccc1)c1ccco1 10.1016/j.bmcl.2011.03.073
468 2634 None 16 Human Functional pKi = 8.5 8.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 389 3 1 6 4.4 Clc1ccc2c(c1)c1nc(nn1c(n2)NC(=O)c1ccccc1)c1ccco1 10.1016/j.bmcl.2011.03.073
CHEMBL317382 2634 None 16 Human Functional pKi = 8.5 8.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 389 3 1 6 4.4 Clc1ccc2c(c1)c1nc(nn1c(n2)NC(=O)c1ccccc1)c1ccco1 10.1016/j.bmcl.2011.03.073
44427587 144258 None 0 Human Functional pKi = 8.5 8.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 394 4 1 5 4.8 COc1ccc(-n2cc3c(n2)c(NC(=O)c2ccccc2)nc2ccccc23)cc1 10.1016/j.bmcl.2011.03.073
CHEMBL390407 144258 None 0 Human Functional pKi = 8.5 8.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 394 4 1 5 4.8 COc1ccc(-n2cc3c(n2)c(NC(=O)c2ccccc2)nc2ccccc23)cc1 10.1016/j.bmcl.2011.03.073
11812897 120363 None 0 Human Functional pKi = 8.4 8.4 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 484 6 2 8 5.5 CCCCn1cc2c(nc(NC(=O)Nc3ccc(Cl)c(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL352707 120363 None 0 Human Functional pKi = 8.4 8.4 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 484 6 2 8 5.5 CCCCn1cc2c(nc(NC(=O)Nc3ccc(Cl)c(Cl)c3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
10834512 99067 None 0 Human Functional pKi = 8.4 8.4 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 395 4 1 6 3.2 O=C(Cc1ccccc1)Nc1nc2ccccc2n2c(=O)n(-c3ccccc3)nc12 10.1016/j.bmcl.2011.03.073
CHEMBL280080 99067 None 0 Human Functional pKi = 8.4 8.4 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 395 4 1 6 3.2 O=C(Cc1ccccc1)Nc1nc2ccccc2n2c(=O)n(-c3ccccc3)nc12 10.1016/j.bmcl.2011.03.073
443 755 None 9 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 382 7 2 6 2.5 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)/C=C/C(=O)O 10.1021/jm990421v
6439089 755 None 9 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 382 7 2 6 2.5 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)/C=C/C(=O)O 10.1021/jm990421v
CHEMBL16997 755 None 9 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 382 7 2 6 2.5 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)/C=C/C(=O)O 10.1021/jm990421v
10007115 116408 None 0 Human Functional pKi = 6.5 6.5 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 527 8 1 8 5.7 O=C(Cc1cccc2ccccc12)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL335950 116408 None 0 Human Functional pKi = 6.5 6.5 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 527 8 1 8 5.7 O=C(Cc1cccc2ccccc12)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
11826924 118809 None 0 Human Functional pKi = 6.5 6.5 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 479 8 1 9 4.0 O=C(COc1ccccc1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL341777 118809 None 0 Human Functional pKi = 6.5 6.5 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 479 8 1 9 4.0 O=C(COc1ccccc1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
10587109 118849 None 0 Human Functional pKi = 6.5 6.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 255 1 1 8 0.9 Cn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL342059 118849 None 0 Human Functional pKi = 6.5 6.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 255 1 1 8 0.9 Cn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
10839228 59885 None 0 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 504 8 2 8 2.1 CCCn1c(=O)c2nc(-c3ccc(/C=C/C(=O)NN4C(=O)C(C)=C(C)C4=O)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
CHEMBL17294 59885 None 0 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 504 8 2 8 2.1 CCCn1c(=O)c2nc(-c3ccc(/C=C/C(=O)NN4C(=O)C(C)=C(C)C4=O)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
21916394 160907 None 0 Human Functional pKi = 6.5 6.5 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 458 6 1 7 3.2 CCn1c(=O)n(CC2CC2)c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc21 10.1016/j.ejmech.2010.04.039
CHEMBL411452 160907 None 0 Human Functional pKi = 6.5 6.5 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 458 6 1 7 3.2 CCn1c(=O)n(CC2CC2)c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc21 10.1016/j.ejmech.2010.04.039
10638807 58242 None 0 Human Functional pKi = 6.5 6.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 311 1 1 6 2.3 Nc1nc2ccccc2n2c(=O)n(-c3ccc(Cl)cc3)nc12 10.1016/j.bmcl.2011.03.073
CHEMBL16820 58242 None 0 Human Functional pKi = 6.5 6.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 311 1 1 6 2.3 Nc1nc2ccccc2n2c(=O)n(-c3ccc(Cl)cc3)nc12 10.1016/j.bmcl.2011.03.073
23657106 153409 None 0 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 311 1 1 6 2.2 Nc1nc2ccccc2n2c(=O)c(-c3ccc(Cl)cc3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL397821 153409 None 0 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 311 1 1 6 2.2 Nc1nc2ccccc2n2c(=O)c(-c3ccc(Cl)cc3)nn12 10.1016/j.bmcl.2011.03.073
10659581 28813 None 0 Human Functional pKi = 6.5 6.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 269 2 1 8 1.3 CCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL137879 28813 None 0 Human Functional pKi = 6.5 6.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 269 2 1 8 1.3 CCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
135508372 67271 None 0 Human Functional pKi = 7.5 7.5 - 1
Inhibition of cAMP accumulation in human adenosine A3 receptor assay as inhibition of Cl-IB-MECAInhibition of cAMP accumulation in human adenosine A3 receptor assay as inhibition of Cl-IB-MECA
ChEMBL 275 1 1 4 3.6 Cc1ccc(-n2cc3c(O)nc4ccccc4c3n2)cc1 10.1021/jm050125k
CHEMBL188035 67271 None 0 Human Functional pKi = 7.5 7.5 - 1
Inhibition of cAMP accumulation in human adenosine A3 receptor assay as inhibition of Cl-IB-MECAInhibition of cAMP accumulation in human adenosine A3 receptor assay as inhibition of Cl-IB-MECA
ChEMBL 275 1 1 4 3.6 Cc1ccc(-n2cc3c(O)nc4ccccc4c3n2)cc1 10.1021/jm050125k
23657105 89389 None 0 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 277 1 1 6 1.6 Nc1nc2ccccc2n2c(=O)c(-c3ccccc3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL236958 89389 None 0 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 277 1 1 6 1.6 Nc1nc2ccccc2n2c(=O)c(-c3ccccc3)nn12 10.1016/j.bmcl.2011.03.073
9870719 57434 None 0 Human Functional pKi = 6.5 6.5 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 503 10 2 8 3.6 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4cccc(C(C)=O)c4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
CHEMBL16534 57434 None 0 Human Functional pKi = 6.5 6.5 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 503 10 2 8 3.6 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4cccc(C(C)=O)c4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
135911562 200540 None 0 Human Functional pKi = 6.5 6.5 - 0
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation countingAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation counting
ChEMBL 240 1 1 4 1.7 Cc1cccc(-n2cc3nc(C)[nH]c(=O)c3n2)c1 10.1021/jm900718w
CHEMBL574352 200540 None 0 Human Functional pKi = 6.5 6.5 - 0
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation countingAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation counting
ChEMBL 240 1 1 4 1.7 Cc1cccc(-n2cc3nc(C)[nH]c(=O)c3n2)c1 10.1021/jm900718w
9936467 58109 None 1 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 519 10 2 9 3.2 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C(=O)OC)cc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
CHEMBL16741 58109 None 1 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 519 10 2 9 3.2 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C(=O)OC)cc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
23656931 88535 None 0 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 295 1 1 6 1.7 Nc1nc2ccccc2n2c(=O)c(-c3ccc(F)cc3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL235071 88535 None 0 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 295 1 1 6 1.7 Nc1nc2ccccc2n2c(=O)c(-c3ccc(F)cc3)nn12 10.1016/j.bmcl.2011.03.073
21874755 176997 None 1 Human Functional pKi = 5.4 5.4 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 336 4 2 8 1.8 Nc1nc(-c2ccco2)c2nnn(Cc3cccc(C(=O)O)c3)c2n1 10.1016/j.ejmech.2010.04.039
CHEMBL461656 176997 None 1 Human Functional pKi = 5.4 5.4 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 336 4 2 8 1.8 Nc1nc(-c2ccco2)c2nnn(Cc3cccc(C(=O)O)c3)c2n1 10.1016/j.ejmech.2010.04.039
CHEMBL5074992 216838 None 0 Human Functional pKi = 7.4 7.4 - 0
Antagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay
ChEMBL None None None CCCCn1c(=O)c2nc(C34CCC(C(=O)NCCOCCOCCN=[N+]=[N-])(CC3)CC4)[nH]c2n(CCCNC(=O)c2ccc(S(=O)(=O)F)cc2)c1=O 10.1021/acs.jmedchem.0c02169
10767043 59040 None 0 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 479 9 2 7 3.5 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
CHEMBL16929 59040 None 0 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 479 9 2 7 3.5 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
126079 4100 None 29 Human Functional pKi = 5.4 5.4 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 386 8 2 7 1.8 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)O 10.1021/jm990421v
451 4100 None 29 Human Functional pKi = 5.4 5.4 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 386 8 2 7 1.8 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)O 10.1021/jm990421v
CHEMBL27041 4100 None 29 Human Functional pKi = 5.4 5.4 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 386 8 2 7 1.8 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)O 10.1021/jm990421v
CHEMBL5073669 216789 None 0 Human Functional pKi = 8.4 8.4 - 0
Antagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay
ChEMBL None None None CCCCn1c(=O)c2nc(C34CCC(C(=O)NCCCN=[N+]=[N-])(CC3)CC4)[nH]c2n(CCCNC(=O)c2ccc(S(=O)(=O)F)cc2)c1=O 10.1021/acs.jmedchem.0c02169
42626221 179519 None 12 Human Functional pKi = 8.3 8.3 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 412 4 1 8 2.7 COc1ccc(-n2nc3c(NC(=O)c4ccccc4)nc4ncccc4n3c2=O)cc1 10.1016/j.bmcl.2011.03.073
CHEMBL474016 179519 None 12 Human Functional pKi = 8.3 8.3 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 412 4 1 8 2.7 COc1ccc(-n2nc3c(NC(=O)c4ccccc4)nc4ncccc4n3c2=O)cc1 10.1016/j.bmcl.2011.03.073
44388246 60506 None 0 Human Functional pKi = 8.3 8.3 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 444 5 2 8 3.9 CC(C)(C)NC(=O)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL175494 60506 None 0 Human Functional pKi = 8.3 8.3 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 444 5 2 8 3.9 CC(C)(C)NC(=O)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL5089483 217699 None 0 Human Functional pKi = 8.3 8.3 - 0
Antagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay
ChEMBL None None None CCCCn1c(=O)c2nc(C34CCC(C(=O)NCCCCN=[N+]=[N-])(CC3)CC4)[nH]c2n(CCCNC(=O)c2ccc(S(=O)(=O)F)cc2)c1=O 10.1021/acs.jmedchem.0c02169
11027412 29637 None 0 Human Functional pKi = 7.4 7.4 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 493 9 1 9 4.4 O=C(COc1ccccc1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL138593 29637 None 0 Human Functional pKi = 7.4 7.4 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 493 9 1 9 4.4 O=C(COc1ccccc1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
11762418 57195 None 0 Human Functional pKi = 7.4 7.4 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 468 5 3 10 2.6 CCn1cc2c(nc(NC(=O)Nc3ccc(S(=O)(=O)O)cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL164867 57195 None 0 Human Functional pKi = 7.4 7.4 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 468 5 3 10 2.6 CCn1cc2c(nc(NC(=O)Nc3ccc(S(=O)(=O)O)cc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
11568203 96297 None 0 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 432 5 1 7 2.8 CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc2n(C)c1=O 10.1016/j.ejmech.2010.04.039
CHEMBL260975 96297 None 0 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 432 5 1 7 2.8 CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc2n(C)c1=O 10.1016/j.ejmech.2010.04.039
10779327 119473 None 0 Human Functional pKi = 6.4 6.4 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 283 3 1 8 1.7 CCCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL344706 119473 None 0 Human Functional pKi = 6.4 6.4 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 283 3 1 8 1.7 CCCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
135405767 124121 None 0 Human Functional pKi = 7.4 7.4 - 0
Inhibition of cAMP accumulation in human adenosine A3 receptor assay as inhibition of Cl-IB-MECAInhibition of cAMP accumulation in human adenosine A3 receptor assay as inhibition of Cl-IB-MECA
ChEMBL 291 2 1 5 3.3 COc1ccc(-n2cc3c(O)nc4ccccc4c3n2)cc1 10.1021/jm050125k
CHEMBL363150 124121 None 0 Human Functional pKi = 7.4 7.4 - 0
Inhibition of cAMP accumulation in human adenosine A3 receptor assay as inhibition of Cl-IB-MECAInhibition of cAMP accumulation in human adenosine A3 receptor assay as inhibition of Cl-IB-MECA
ChEMBL 291 2 1 5 3.3 COc1ccc(-n2cc3c(O)nc4ccccc4c3n2)cc1 10.1021/jm050125k
CHEMBL5092788 217879 None 0 Human Functional pKi = 7.4 7.4 - 0
Antagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay
ChEMBL None None None C#CCCCCNC(=O)C12CCC(c3nc4c(=O)n(CCCC)c(=O)n(CCCNC(=O)c5ccc(S(=O)(=O)F)cc5)c4[nH]3)(CC1)CC2 10.1021/acs.jmedchem.0c02169
10737168 165430 None 0 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 359 5 1 8 2.9 Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL423542 165430 None 0 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 359 5 1 8 2.9 Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
10994216 195980 None 0 Human Functional pKi = 7.4 7.4 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 463 7 1 8 4.2 O=C(Cc1ccccc1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL541455 195980 None 0 Human Functional pKi = 7.4 7.4 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 463 7 1 8 4.2 O=C(Cc1ccccc1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
10709852 56586 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 307 2 1 7 1.6 COc1ccc(-n2nc3c(N)nc4ccccc4n3c2=O)cc1 10.1016/j.bmcl.2011.03.073
CHEMBL16416 56586 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 307 2 1 7 1.6 COc1ccc(-n2nc3c(N)nc4ccccc4n3c2=O)cc1 10.1016/j.bmcl.2011.03.073
450 2970 None 7 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 525 10 3 6 3.6 CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1 10.1016/j.ejmech.2010.04.039
454 2970 None 7 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 525 10 3 6 3.6 CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1 10.1016/j.ejmech.2010.04.039
5311041 2970 None 7 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 525 10 3 6 3.6 CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1 10.1016/j.ejmech.2010.04.039
CHEMBL485862 2970 None 7 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 525 10 3 6 3.6 CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1 10.1016/j.ejmech.2010.04.039
135911561 201308 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation countingAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation counting
ChEMBL 240 1 1 4 1.7 Cc1ccc(-n2cc3nc(C)[nH]c(=O)c3n2)cc1 10.1021/jm900718w
CHEMBL583794 201308 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation countingAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation counting
ChEMBL 240 1 1 4 1.7 Cc1ccc(-n2cc3nc(C)[nH]c(=O)c3n2)cc1 10.1021/jm900718w
CHEMBL5089727 217713 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay
ChEMBL None None None C#CCNC(=O)C12CCC(c3nc4c(=O)n(CCCC)c(=O)n(CCCNC(=O)c5ccc(S(=O)(=O)F)cc5)c4[nH]3)(CC1)CC2 10.1021/acs.jmedchem.0c02169
10755990 98180 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 291 1 1 6 1.9 Cc1ccc(-n2nc3c(N)nc4ccccc4n3c2=O)cc1 10.1016/j.bmcl.2011.03.073
CHEMBL273578 98180 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 291 1 1 6 1.9 Cc1ccc(-n2nc3c(N)nc4ccccc4n3c2=O)cc1 10.1016/j.bmcl.2011.03.073
42626156 189804 None 0 Human Functional pKi = 6.3 6.3 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 296 1 1 7 1.2 Nc1nc2ncccc2n2c(=O)n(-c3ccc(F)cc3)nc12 10.1016/j.bmcl.2011.03.073
CHEMBL515433 189804 None 0 Human Functional pKi = 6.3 6.3 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 296 1 1 7 1.2 Nc1nc2ncccc2n2c(=O)n(-c3ccc(F)cc3)nc12 10.1016/j.bmcl.2011.03.073
393595 2637 None 36 Human Functional pKi = 8.3 8.3 16 3
Antagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay
ChEMBL 403 4 1 6 4.4 O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1 10.1021/acs.jmedchem.0c02169
448 2637 None 36 Human Functional pKi = 8.3 8.3 16 3
Antagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay
ChEMBL 403 4 1 6 4.4 O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1 10.1021/acs.jmedchem.0c02169
CHEMBL88147 2637 None 36 Human Functional pKi = 8.3 8.3 16 3
Antagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay
ChEMBL 403 4 1 6 4.4 O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1 10.1021/acs.jmedchem.0c02169
135911557 200520 None 0 Human Functional pKi = 8.3 8.3 - 0
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation countingAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation counting
ChEMBL 256 2 1 5 1.4 COc1ccc(-n2cc3nc(C)[nH]c(=O)c3n2)cc1 10.1021/jm900718w
CHEMBL574132 200520 None 0 Human Functional pKi = 8.3 8.3 - 0
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation countingAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation counting
ChEMBL 256 2 1 5 1.4 COc1ccc(-n2cc3nc(C)[nH]c(=O)c3n2)cc1 10.1021/jm900718w
10895565 168555 None 0 Human Functional pKi = 7.3 7.3 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 445 8 1 9 3.8 CC(C)CCn1cc2c(nc(NC(=O)COc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL435022 168555 None 0 Human Functional pKi = 7.3 7.3 - 1
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 445 8 1 9 3.8 CC(C)CCn1cc2c(nc(NC(=O)COc3ccccc3)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
46887898 9105 None 0 Human Functional pKi = 6.3 6.3 - 0
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NSCA-induced decrease in cAMP level pre-incubated for 15 mins by enzyme immunoassayAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NSCA-induced decrease in cAMP level pre-incubated for 15 mins by enzyme immunoassay
ChEMBL 316 3 1 4 3.1 Cc1ccc(-c2ncc3[nH]c(=O)n(Cc4ccccc4)c3n2)cc1 10.1016/j.bmc.2010.03.048
CHEMBL1099202 9105 None 0 Human Functional pKi = 6.3 6.3 - 0
Antagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NSCA-induced decrease in cAMP level pre-incubated for 15 mins by enzyme immunoassayAntagonist activity at human adenosine A3 receptor expressed in forskolin-stimulated CHO cells assessed as inhibition of NSCA-induced decrease in cAMP level pre-incubated for 15 mins by enzyme immunoassay
ChEMBL 316 3 1 4 3.1 Cc1ccc(-c2ncc3[nH]c(=O)n(Cc4ccccc4)c3n2)cc1 10.1016/j.bmc.2010.03.048
23657107 88536 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 307 2 1 7 1.6 COc1ccc(-c2nn3c(N)nc4ccccc4n3c2=O)cc1 10.1016/j.bmcl.2011.03.073
CHEMBL235075 88536 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 307 2 1 7 1.6 COc1ccc(-c2nn3c(N)nc4ccccc4n3c2=O)cc1 10.1016/j.bmcl.2011.03.073
12293993 156540 None 8 Human Functional pKi = 5.3 5.3 - 0
Antagonist activity at A3 adenosine receptor (unknown origin)Antagonist activity at A3 adenosine receptor (unknown origin)
ChEMBL 291 2 1 5 3.1 Nc1nc(-c2ccccc2)cc(-c2ccc3c(c2)OCO3)n1 10.1021/acs.jmedchem.1c01636
CHEMBL406714 156540 None 8 Human Functional pKi = 5.3 5.3 - 0
Antagonist activity at A3 adenosine receptor (unknown origin)Antagonist activity at A3 adenosine receptor (unknown origin)
ChEMBL 291 2 1 5 3.1 Nc1nc(-c2ccccc2)cc(-c2ccc3c(c2)OCO3)n1 10.1021/acs.jmedchem.1c01636
9870396 139124 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 494 7 1 7 4.3 CCCn1c(=O)c2nc(-c3cnn(Cc4cc(C(F)(F)F)ccc4Cl)c3)[nH]c2n(CCC)c1=O 10.1016/j.ejmech.2010.04.039
CHEMBL378598 139124 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 494 7 1 7 4.3 CCCn1c(=O)c2nc(-c3cnn(Cc4cc(C(F)(F)F)ccc4Cl)c3)[nH]c2n(CCC)c1=O 10.1016/j.ejmech.2010.04.039
135454766 125102 None 0 Human Functional pKi = 7.3 7.3 - 0
Inhibition of cAMP accumulation in human adenosine A3 receptor assay as inhibition of Cl-IB-MECAInhibition of cAMP accumulation in human adenosine A3 receptor assay as inhibition of Cl-IB-MECA
ChEMBL 261 1 1 4 3.3 Oc1nc2ccccc2c2nn(-c3ccccc3)cc12 10.1021/jm050125k
CHEMBL364319 125102 None 0 Human Functional pKi = 7.3 7.3 - 0
Inhibition of cAMP accumulation in human adenosine A3 receptor assay as inhibition of Cl-IB-MECAInhibition of cAMP accumulation in human adenosine A3 receptor assay as inhibition of Cl-IB-MECA
ChEMBL 261 1 1 4 3.3 Oc1nc2ccccc2c2nn(-c3ccccc3)cc12 10.1021/jm050125k
10043187 99093 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 345 3 1 6 3.4 O=c1n(-c2ccccc2)nc2c(NC3CCCC3)nc3ccccc3n12 10.1016/j.bmcl.2011.03.073
CHEMBL280278 99093 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 345 3 1 6 3.4 O=c1n(-c2ccccc2)nc2c(NC3CCCC3)nc3ccccc3n12 10.1016/j.bmcl.2011.03.073
10763173 57854 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 393 3 1 6 4.4 O=c1n(-c2ccc(Cl)cc2)nc2c(NC3CCCCC3)nc3ccccc3n12 10.1016/j.bmcl.2011.03.073
CHEMBL16715 57854 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 393 3 1 6 4.4 O=c1n(-c2ccc(Cl)cc2)nc2c(NC3CCCCC3)nc3ccccc3n12 10.1016/j.bmcl.2011.03.073
449 2643 None 38 Human Functional pKi = 6.2 6.2 - 4
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 486 9 2 8 3.3 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N 10.1016/j.ejmech.2010.04.039
453 2643 None 38 Human Functional pKi = 6.2 6.2 - 4
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 486 9 2 8 3.3 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N 10.1016/j.ejmech.2010.04.039
6603931 2643 None 38 Human Functional pKi = 6.2 6.2 - 4
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 486 9 2 8 3.3 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N 10.1016/j.ejmech.2010.04.039
CHEMBL273807 2643 None 38 Human Functional pKi = 6.2 6.2 - 4
Antagonist activity against human adenosine A3 receptorAntagonist activity against human adenosine A3 receptor
ChEMBL 486 9 2 8 3.3 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N 10.1016/j.ejmech.2010.04.039
449 2643 None 38 Human Functional pKi = 6.2 6.2 - 4
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 486 9 2 8 3.3 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N 10.1021/jm990421v
453 2643 None 38 Human Functional pKi = 6.2 6.2 - 4
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 486 9 2 8 3.3 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N 10.1021/jm990421v
6603931 2643 None 38 Human Functional pKi = 6.2 6.2 - 4
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 486 9 2 8 3.3 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N 10.1021/jm990421v
CHEMBL273807 2643 None 38 Human Functional pKi = 6.2 6.2 - 4
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 486 9 2 8 3.3 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N 10.1021/jm990421v
127041420 136898 None 0 Human Functional pKi = 8.2 8.2 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as cAMP level measured by enzyme immunoassayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as cAMP level measured by enzyme immunoassay
ChEMBL 496 8 4 14 0.5 CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(NC(C)Cc5ccc(OC)cc5)nc43)[C@H](O)[C@@H]2O)n1 10.1016/j.ejmech.2021.113907
CHEMBL3741543 136898 None 0 Human Functional pKi = 8.2 8.2 - 1
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as cAMP level measured by enzyme immunoassayAntagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as cAMP level measured by enzyme immunoassay
ChEMBL 496 8 4 14 0.5 CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(NC(C)Cc5ccc(OC)cc5)nc43)[C@H](O)[C@@H]2O)n1 10.1016/j.ejmech.2021.113907
10601859 119214 None 0 Human Functional pKi = 7.2 7.2 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 512 7 2 8 5.7 O=C(Nc1cccc(Cl)c1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL342906 119214 None 0 Human Functional pKi = 7.2 7.2 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 512 7 2 8 5.7 O=C(Nc1cccc(Cl)c1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
10637742 58969 None 0 Human Functional pKi = 6.2 6.2 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 297 4 1 8 2.1 CCCCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL16894 58969 None 0 Human Functional pKi = 6.2 6.2 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 297 4 1 8 2.1 CCCCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
9870718 60006 None 0 Human Functional pKi = 7.2 7.2 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 503 10 2 8 3.6 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccccc4C(C)=O)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
CHEMBL17341 60006 None 0 Human Functional pKi = 7.2 7.2 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 503 10 2 8 3.6 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccccc4C(C)=O)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
135911558 200584 None 0 Human Functional pKi = 7.2 7.2 - 0
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation countingAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation counting
ChEMBL 270 3 1 5 1.7 CCc1nc2cn(-c3ccc(OC)cc3)nc2c(=O)[nH]1 10.1021/jm900718w
CHEMBL574624 200584 None 0 Human Functional pKi = 7.2 7.2 - 0
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation countingAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation counting
ChEMBL 270 3 1 5 1.7 CCc1nc2cn(-c3ccc(OC)cc3)nc2c(=O)[nH]1 10.1021/jm900718w
44388211 62120 None 0 Human Functional pKi = 7.2 7.2 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 458 6 2 8 4.3 CC(C)(C)NC(=O)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL177524 62120 None 0 Human Functional pKi = 7.2 7.2 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 458 6 2 8 4.3 CC(C)(C)NC(=O)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
44388252 63434 None 0 Human Functional pKi = 7.2 7.2 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 396 6 2 8 3.3 CC(C)CCn1cc2c(nc(NC(=O)NC(C)C)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL179638 63434 None 0 Human Functional pKi = 7.2 7.2 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 396 6 2 8 3.3 CC(C)CCn1cc2c(nc(NC(=O)NC(C)C)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
9936058 59577 None 2 Human Functional pKi = 6.2 6.2 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 508 9 2 9 1.5 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)NN4C(=O)C(C)=C(C)C4=O)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
CHEMBL17173 59577 None 2 Human Functional pKi = 6.2 6.2 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 508 9 2 9 1.5 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)NN4C(=O)C(C)=C(C)C4=O)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
42626004 179454 None 0 Human Functional pKi = 7.2 7.2 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 382 3 1 7 2.7 O=C(Nc1nc2ncccc2n2c(=O)n(-c3ccccc3)nc12)c1ccccc1 10.1016/j.bmcl.2011.03.073
CHEMBL473650 179454 None 0 Human Functional pKi = 7.2 7.2 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 382 3 1 7 2.7 O=C(Nc1nc2ncccc2n2c(=O)n(-c3ccccc3)nc12)c1ccccc1 10.1016/j.bmcl.2011.03.073
10852506 107037 None 0 Human Functional pKi = 6.2 6.2 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 311 4 1 8 2.4 CC(C)CCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
CHEMBL315150 107037 None 0 Human Functional pKi = 6.2 6.2 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 311 4 1 8 2.4 CC(C)CCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1 10.1016/j.bmcl.2011.03.073
135911551 200425 None 0 Human Functional pKi = 6.1 6.1 - 0
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation countingAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation counting
ChEMBL 212 1 1 4 1.1 O=c1[nH]cnc2cn(-c3ccccc3)nc12 10.1021/jm900718w
CHEMBL573502 200425 None 0 Human Functional pKi = 6.1 6.1 - 0
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation countingAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation counting
ChEMBL 212 1 1 4 1.1 O=c1[nH]cnc2cn(-c3ccccc3)nc12 10.1021/jm900718w
126079 4100 None 29 Rat Functional pKi = 4.1 4.1 - 0
Antagonist activity against rat adenosine A3 receptor using [125I]I-AB-MECA or [125 I]IABAAntagonist activity against rat adenosine A3 receptor using [125I]I-AB-MECA or [125 I]IABA
ChEMBL 386 8 2 7 1.8 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)O 10.1021/jm990421v
451 4100 None 29 Rat Functional pKi = 4.1 4.1 - 0
Antagonist activity against rat adenosine A3 receptor using [125I]I-AB-MECA or [125 I]IABAAntagonist activity against rat adenosine A3 receptor using [125I]I-AB-MECA or [125 I]IABA
ChEMBL 386 8 2 7 1.8 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)O 10.1021/jm990421v
CHEMBL27041 4100 None 29 Rat Functional pKi = 4.1 4.1 - 0
Antagonist activity against rat adenosine A3 receptor using [125I]I-AB-MECA or [125 I]IABAAntagonist activity against rat adenosine A3 receptor using [125I]I-AB-MECA or [125 I]IABA
ChEMBL 386 8 2 7 1.8 CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)O 10.1021/jm990421v
9912816 98487 None 0 Human Functional pKi = 7.1 7.1 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 475 10 2 7 3.1 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)NCc4ccccc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
CHEMBL275605 98487 None 0 Human Functional pKi = 7.1 7.1 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 475 10 2 7 3.1 CCCn1c(=O)c2nc(-c3ccc(OCC(=O)NCc4ccccc4)cc3)[nH]c2n(CCC)c1=O 10.1021/jm990421v
CHEMBL5088372 217645 None 0 Human Functional pKi = 8.1 8.1 - 0
Antagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay
ChEMBL None None None CCCCn1c(=O)c2nc(C34CCC(C(=O)NCCOCCOCCOCCN=[N+]=[N-])(CC3)CC4)[nH]c2n(CCCNC(=O)c2ccc(S(=O)(=O)F)cc2)c1=O 10.1021/acs.jmedchem.0c02169
54587662 61438 None 0 Human Functional pKi = 8.1 8.1 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 507 7 1 7 5.2 O=C(Cc1ccccc1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccc(Cl)cc3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL1770311 61438 None 0 Human Functional pKi = 8.1 8.1 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 507 7 1 7 5.2 O=C(Cc1ccccc1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccc(Cl)cc3)nn12 10.1016/j.bmcl.2011.03.073
54587662 61438 None 0 Human Functional pKi = 8.1 8.1 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 507 7 1 7 5.2 O=C(Cc1ccccc1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccc(Cl)cc3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL1770311 61438 None 0 Human Functional pKi = 8.1 8.1 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 507 7 1 7 5.2 O=C(Cc1ccccc1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccc(Cl)cc3)nn12 10.1016/j.bmcl.2011.03.073
541903 57964 None 0 Human Functional pKi = 6.1 6.1 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 382 8 2 7 1.4 C=CCn1c(=O)c2nc(-c3ccc(OCC(=O)O)cc3)[nH]c2n(CC=C)c1=O 10.1021/jm990421v
CHEMBL16724 57964 None 0 Human Functional pKi = 6.1 6.1 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 382 8 2 7 1.4 C=CCn1c(=O)c2nc(-c3ccc(OCC(=O)O)cc3)[nH]c2n(CC=C)c1=O 10.1021/jm990421v
135911560 200586 None 0 Human Functional pKi = 6.1 6.1 - 0
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation countingAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation counting
ChEMBL 332 4 1 5 2.7 COc1ccc(-n2cc3nc(Cc4ccccc4)[nH]c(=O)c3n2)cc1 10.1021/jm900718w
CHEMBL574639 200586 None 0 Human Functional pKi = 6.1 6.1 - 0
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation countingAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation counting
ChEMBL 332 4 1 5 2.7 COc1ccc(-n2cc3nc(Cc4ccccc4)[nH]c(=O)c3n2)cc1 10.1021/jm900718w
135911552 201195 None 0 Human Functional pKi = 7.1 7.1 - 0
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation countingAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation counting
ChEMBL 226 1 1 4 1.4 Cc1nc2cn(-c3ccccc3)nc2c(=O)[nH]1 10.1021/jm900718w
CHEMBL582911 201195 None 0 Human Functional pKi = 7.1 7.1 - 0
Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation countingAntagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-inhibited [3H]cAMP production by scintillation counting
ChEMBL 226 1 1 4 1.4 Cc1nc2cn(-c3ccccc3)nc2c(=O)[nH]1 10.1021/jm900718w
44388242 123352 None 0 Human Functional pKi = 8.1 8.1 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 430 6 2 8 3.5 CC(C)NC(=O)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
CHEMBL361412 123352 None 0 Human Functional pKi = 8.1 8.1 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 430 6 2 8 3.5 CC(C)NC(=O)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12 10.1016/j.bmcl.2011.03.073
10732242 5164 None 0 Human Functional pKi = 7.0 7.0 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 290 2 1 5 3.2 COc1ccc(-n2cc3c(n2)c(N)nc2ccccc23)cc1 10.1016/j.bmcl.2011.03.073
CHEMBL105913 5164 None 0 Human Functional pKi = 7.0 7.0 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 290 2 1 5 3.2 COc1ccc(-n2cc3c(n2)c(N)nc2ccccc23)cc1 10.1016/j.bmcl.2011.03.073
10387088 59474 None 0 Human Functional pKi = 7.0 7.0 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells using [125] IAB-MECA or [125 I]IABAAntagonist activity against human adenosine A3 receptor expressed in HEK cells using [125] IAB-MECA or [125 I]IABA
ChEMBL 414 10 2 7 2.6 CCCCn1c(=O)c2nc(-c3ccc(OCC(=O)O)cc3)[nH]c2n(CCCC)c1=O 10.1021/jm990421v
CHEMBL17123 59474 None 0 Human Functional pKi = 7.0 7.0 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells using [125] IAB-MECA or [125 I]IABAAntagonist activity against human adenosine A3 receptor expressed in HEK cells using [125] IAB-MECA or [125 I]IABA
ChEMBL 414 10 2 7 2.6 CCCCn1c(=O)c2nc(-c3ccc(OCC(=O)O)cc3)[nH]c2n(CCCC)c1=O 10.1021/jm990421v
9957239 59434 None 0 Human Functional pKi = 6.0 6.0 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 490 7 2 6 4.8 O=C(O)/C=C/c1ccc(-c2nc3c(=O)n(CC4CCCCC4)c(=O)n(CC4CCCCC4)c3[nH]2)cc1 10.1021/jm990421v
CHEMBL17103 59434 None 0 Human Functional pKi = 6.0 6.0 - 0
Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.
ChEMBL 490 7 2 6 4.8 O=C(O)/C=C/c1ccc(-c2nc3c(=O)n(CC4CCCCC4)c(=O)n(CC4CCCCC4)c3[nH]2)cc1 10.1021/jm990421v
10741090 55659 None 0 Human Functional pKi = 6.0 6.0 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 426 4 2 7 3.7 COc1ccc(NC(=O)Nc2nc3ccccc3n3c(=O)n(-c4ccccc4)nc23)cc1 10.1016/j.bmcl.2011.03.073
CHEMBL16215 55659 None 0 Human Functional pKi = 6.0 6.0 - 0
Antagonist activity at human adenosine A3 receptorAntagonist activity at human adenosine A3 receptor
ChEMBL 426 4 2 7 3.7 COc1ccc(NC(=O)Nc2nc3ccccc3n3c(=O)n(-c4ccccc4)nc23)cc1 10.1016/j.bmcl.2011.03.073
656511 220202 None 0 Human Functional pIC50 = 8.3 8.3 -1 2
NoneNone
Drug Central 539 6 3 8 -0.2 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCN(C3=O)S(C)(=O)=O)C3=CC=CC=C3)C(=O)N2[C@H]1C(O)=O None
1310 2315 None 61 Human Functional pIC50 = 8.2 8.2 2 17
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 147 4 3 3 -0.7 OC(=O)CC[C@@H](C(=O)O)N None
1369 2315 None 61 Human Functional pIC50 = 8.2 8.2 2 17
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 147 4 3 3 -0.7 OC(=O)CC[C@@H](C(=O)O)N None
33032 2315 None 61 Human Functional pIC50 = 8.2 8.2 2 17
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 147 4 3 3 -0.7 OC(=O)CC[C@@H](C(=O)O)N None
44272391 2315 None 61 Human Functional pIC50 = 8.2 8.2 2 17
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 147 4 3 3 -0.7 OC(=O)CC[C@@H](C(=O)O)N None
88747398 2315 None 61 Human Functional pIC50 = 8.2 8.2 2 17
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 147 4 3 3 -0.7 OC(=O)CC[C@@H](C(=O)O)N None
CHEMBL575060 2315 None 61 Human Functional pIC50 = 8.2 8.2 2 17
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 147 4 3 3 -0.7 OC(=O)CC[C@@H](C(=O)O)N None
DB00142 2315 None 61 Human Functional pIC50 = 8.2 8.2 2 17
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 147 4 3 3 -0.7 OC(=O)CC[C@@H](C(=O)O)N None
135398737 958 None 57 Human Functional pIC50 = 8.2 8.2 -3 43
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
135398737.0 958 None 57 Human Functional pIC50 = 8.2 8.2 -3 43
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 958 None 57 Human Functional pIC50 = 8.2 8.2 -3 43
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 958 None 57 Human Functional pIC50 = 8.2 8.2 -3 43
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 958 None 57 Human Functional pIC50 = 8.2 8.2 -3 43
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 958 None 57 Human Functional pIC50 = 8.2 8.2 -3 43
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
102 4127 None 36 Human Functional pIC50 = 8.2 8.2 -44 20
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 4127 None 36 Human Functional pIC50 = 8.2 8.2 -44 20
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 4127 None 36 Human Functional pIC50 = 8.2 8.2 -44 20
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969.0 4127 None 36 Human Functional pIC50 = 8.2 8.2 -44 20
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 4127 None 36 Human Functional pIC50 = 8.2 8.2 -44 20
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 4127 None 36 Human Functional pIC50 = 8.2 8.2 -44 20
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
11671467 220232 None 0 Human Functional pIC50 = 8.2 8.2 - 1
NoneNone
Drug Central 580 10 4 12 3.1 COC1=CC(NC2=NC(NC3=CC=C4OC(C)(C)C(=O)N(COP(O)(O)=O)C4=N3)=C(F)C=N2)=CC(OC)=C1OC None
10255 98384 None 39 Human Functional pIC50 = 8.2 8.2 4786 2
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 213 4 3 3 0.3 C=C(C)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O None
44338126 98384 None 39 Human Functional pIC50 = 8.2 8.2 4786 2
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 213 4 3 3 0.3 C=C(C)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O None
CHEMBL275040 98384 None 39 Human Functional pIC50 = 8.2 8.2 4786 2
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 213 4 3 3 0.3 C=C(C)[C@H]1CN[C@H](C(=O)O)[C@H]1CC(=O)O None
2284 206531 None 76 Human Functional pIC50 = 8.1 8.1 13 3
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 213 4 2 2 1.9 NCC(CC(=O)O)c1ccc(Cl)cc1 None
2284.0 206531 None 76 Human Functional pIC50 = 8.1 8.1 13 3
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 213 4 2 2 1.9 NCC(CC(=O)O)c1ccc(Cl)cc1 None
CHEMBL701 206531 None 76 Human Functional pIC50 = 8.1 8.1 13 3
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 213 4 2 2 1.9 NCC(CC(=O)O)c1ccc(Cl)cc1 None
DB00181 206531 None 76 Human Functional pIC50 = 8.1 8.1 13 3
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 213 4 2 2 1.9 NCC(CC(=O)O)c1ccc(Cl)cc1 None
2200 3131 None 31 Human Functional pIC50 = 8.1 8.1 3 10
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 351 2 1 5 1.6 CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2 None
328 3131 None 31 Human Functional pIC50 = 8.1 8.1 3 10
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 351 2 1 5 1.6 CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2 None
4848 3131 None 31 Human Functional pIC50 = 8.1 8.1 3 10
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 351 2 1 5 1.6 CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2 None
4848.0 3131 None 31 Human Functional pIC50 = 8.1 8.1 3 10
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 351 2 1 5 1.6 CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2 None
CHEMBL9967 3131 None 31 Human Functional pIC50 = 8.1 8.1 3 10
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 351 2 1 5 1.6 CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2 None
DB00670 3131 None 31 Human Functional pIC50 = 8.1 8.1 3 10
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 351 2 1 5 1.6 CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2 None
3016 1412 None 23 Human Functional pIC50 = 8.1 8.1 281 2
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 284 1 0 2 3.2 Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1 None
3364 1412 None 23 Human Functional pIC50 = 8.1 8.1 281 2
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 284 1 0 2 3.2 Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1 None
852 1412 None 23 Human Functional pIC50 = 8.1 8.1 281 2
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 284 1 0 2 3.2 Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1 None
CHEMBL12 1412 None 23 Human Functional pIC50 = 8.1 8.1 281 2
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 284 1 0 2 3.2 Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1 None
DB00829 1412 None 23 Human Functional pIC50 = 8.1 8.1 281 2
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 284 1 0 2 3.2 Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1 None
1427 2013 None 42 Human Functional pIC50 = 8.1 8.1 -660 30
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
357 2013 None 42 Human Functional pIC50 = 8.1 8.1 -660 30
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
3696 2013 None 42 Human Functional pIC50 = 8.1 8.1 -660 30
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
CHEMBL11 2013 None 42 Human Functional pIC50 = 8.1 8.1 -660 30
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
DB00458 2013 None 42 Human Functional pIC50 = 8.1 8.1 -660 30
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
1524 2181 None 61 Human Functional pIC50 = 8.1 8.1 -1 18
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 2181 None 61 Human Functional pIC50 = 8.1 8.1 -1 18
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 2181 None 61 Human Functional pIC50 = 8.1 8.1 -1 18
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822.0 2181 None 61 Human Functional pIC50 = 8.1 8.1 -1 18
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 2181 None 61 Human Functional pIC50 = 8.1 8.1 -1 18
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 2181 None 61 Human Functional pIC50 = 8.1 8.1 -1 18
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 2181 None 61 Human Functional pIC50 = 8.1 8.1 -1 18
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
2249 512 None 65 Human Functional pIC50 = 8.1 8.1 18 5
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 266 8 3 4 0.5 OC(COc1ccc(cc1)CC(=O)N)CNC(C)C None
2249.0 512 None 65 Human Functional pIC50 = 8.1 8.1 18 5
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 266 8 3 4 0.5 OC(COc1ccc(cc1)CC(=O)N)CNC(C)C None
255 512 None 65 Human Functional pIC50 = 8.1 8.1 18 5
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 266 8 3 4 0.5 OC(COc1ccc(cc1)CC(=O)N)CNC(C)C None
548 512 None 65 Human Functional pIC50 = 8.1 8.1 18 5
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 266 8 3 4 0.5 OC(COc1ccc(cc1)CC(=O)N)CNC(C)C None
CHEMBL24 512 None 65 Human Functional pIC50 = 8.1 8.1 18 5
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 266 8 3 4 0.5 OC(COc1ccc(cc1)CC(=O)N)CNC(C)C None
DB00335 512 None 65 Human Functional pIC50 = 8.1 8.1 18 5
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 266 8 3 4 0.5 OC(COc1ccc(cc1)CC(=O)N)CNC(C)C None
175540 119319 None 30 Human Functional pIC50 = 8.1 8.1 5 3
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 266 8 3 4 0.5 CC(C)NC[C@H](O)COc1ccc(CC(N)=O)cc1 None
CHEMBL343633 119319 None 30 Human Functional pIC50 = 8.1 8.1 5 3
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 266 8 3 4 0.5 CC(C)NC[C@H](O)COc1ccc(CC(N)=O)cc1 None
1638 2724 None 24 Human Functional pIC50 = 8.1 8.1 -1 9
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 327 2 2 5 1.3 C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O None
1676 2724 None 24 Human Functional pIC50 = 8.1 8.1 -1 9
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 327 2 2 5 1.3 C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O None
1878 2724 None 24 Human Functional pIC50 = 8.1 8.1 -1 9
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 327 2 2 5 1.3 C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O None
5284596 2724 None 24 Human Functional pIC50 = 8.1 8.1 -1 9
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 327 2 2 5 1.3 C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O None
5284596.0 2724 None 24 Human Functional pIC50 = 8.1 8.1 -1 9
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 327 2 2 5 1.3 C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O None
CHEMBL80 2724 None 24 Human Functional pIC50 = 8.1 8.1 -1 9
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 327 2 2 5 1.3 C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O None
DB01183 2724 None 24 Human Functional pIC50 = 8.1 8.1 -1 9
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 327 2 2 5 1.3 C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O None
1227 2489 None 32 Human Functional pIC50 = 8.1 8.1 -2 14
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 285 7 0 4 2.7 COc1ccc(cc1)CN(c1ccccn1)CCN(C)C None
2331 2489 None 32 Human Functional pIC50 = 8.1 8.1 -2 14
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 285 7 0 4 2.7 COc1ccc(cc1)CN(c1ccccn1)CCN(C)C None
3957 2489 None 32 Human Functional pIC50 = 8.1 8.1 -2 14
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 285 7 0 4 2.7 COc1ccc(cc1)CN(c1ccccn1)CCN(C)C None
4992 2489 None 32 Human Functional pIC50 = 8.1 8.1 -2 14
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 285 7 0 4 2.7 COc1ccc(cc1)CN(c1ccccn1)CCN(C)C None
4992.0 2489 None 32 Human Functional pIC50 = 8.1 8.1 -2 14
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 285 7 0 4 2.7 COc1ccc(cc1)CN(c1ccccn1)CCN(C)C None
CHEMBL511 2489 None 32 Human Functional pIC50 = 8.1 8.1 -2 14
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 285 7 0 4 2.7 COc1ccc(cc1)CN(c1ccccn1)CCN(C)C None
DB06691 2489 None 32 Human Functional pIC50 = 8.1 8.1 -2 14
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 285 7 0 4 2.7 COc1ccc(cc1)CN(c1ccccn1)CCN(C)C None
4976 206037 None 20 Human Functional pIC50 = 8.1 8.1 5 15
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 263 4 1 1 4.3 CNCCCC1c2ccccc2C=Cc2ccccc21 None
CHEMBL668 206037 None 20 Human Functional pIC50 = 8.1 8.1 5 15
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 263 4 1 1 4.3 CNCCCC1c2ccccc2C=Cc2ccccc21 None
4209 3163 None 48 Human Functional pIC50 = 8.0 8.0 -30 17
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4893 3163 None 48 Human Functional pIC50 = 8.0 8.0 -30 17
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4893.0 3163 None 48 Human Functional pIC50 = 8.0 8.0 -30 17
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
503 3163 None 48 Human Functional pIC50 = 8.0 8.0 -30 17
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
5385 3163 None 48 Human Functional pIC50 = 8.0 8.0 -30 17
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
CHEMBL2 3163 None 48 Human Functional pIC50 = 8.0 8.0 -30 17
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
DB00457 3163 None 48 Human Functional pIC50 = 8.0 8.0 -30 17
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAInhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None




Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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DOI

3149 12618 None 11 Human Binding pAC50 = 5 5.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 334 15 0 1 6.1 CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1187011 12618 None 11 Human Binding pAC50 = 5 5.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 334 15 0 1 6.1 CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 10.1038/s41467-023-40064-9
6231 29778 None 23 Human Binding pAC50 = 5 5.0 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 298 0 1 2 3.6 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=C(CCC(=O)C4)[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL1387 29778 None 23 Human Binding pAC50 = 5 5.0 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 298 0 1 2 3.6 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=C(CCC(=O)C4)[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
5852 2617 None 48 Human Binding pAC50 = 5 5.0 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
9931891 2617 None 48 Human Binding pAC50 = 5 5.0 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
CHEMBL239226 2617 None 48 Human Binding pAC50 = 5 5.0 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
4463 199955 None 72 Human Binding pAC50 = 6.0 6.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 266 1 1 4 2.7 Cc1ccnc2c1NC(=O)c1cccnc1N2C1CC1 10.1038/s41467-023-40064-9
CHEMBL57 199955 None 72 Human Binding pAC50 = 6.0 6.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 266 1 1 4 2.7 Cc1ccnc2c1NC(=O)c1cccnc1N2C1CC1 10.1038/s41467-023-40064-9
7099 197978 None 47 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 209 0 2 3 2.6 Nc1ccc2cc3ccc(N)cc3nc2c1 10.1038/s41467-023-40064-9
CHEMBL55400 197978 None 47 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 209 0 2 3 2.6 Nc1ccc2cc3ccc(N)cc3nc2c1 10.1038/s41467-023-40064-9
55245 18587 None 43 Human Binding pAC50 = 5.0 5.0 - 3
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 429 2 1 3 5.4 CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C)cc3)C[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL1276308 18587 None 43 Human Binding pAC50 = 5.0 5.0 - 3
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 429 2 1 3 5.4 CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C)cc3)C[C@@]21C 10.1038/s41467-023-40064-9
1547484 940 None 51 Human Binding pAC50 = 5.0 5.0 - 20
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
1547484.0 940 None 51 Human Binding pAC50 = 5.0 5.0 - 20
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
654 940 None 51 Human Binding pAC50 = 5.0 5.0 - 20
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
9072 940 None 51 Human Binding pAC50 = 5.0 5.0 - 20
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL43064 940 None 51 Human Binding pAC50 = 5.0 5.0 - 20
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
DB00568 940 None 51 Human Binding pAC50 = 5.0 5.0 - 20
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
5328940 100270 None 65 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 529 9 1 8 5.2 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl 10.1038/s41467-023-40064-9
CHEMBL288441 100270 None 65 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 529 9 1 8 5.2 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl 10.1038/s41467-023-40064-9
9818306 14424 None 13 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 314 1 1 3 3.8 CC(=O)Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)CC[C@@H]12 10.1038/s41467-023-40064-9
CHEMBL1200430 14424 None 13 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 314 1 1 3 3.8 CC(=O)Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)CC[C@@H]12 10.1038/s41467-023-40064-9
11213558 180546 None 57 Human Binding pAC50 = 7.0 7.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 470 7 3 10 3.6 COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC 10.1038/s41467-023-40064-9
CHEMBL475251 180546 None 57 Human Binding pAC50 = 7.0 7.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 470 7 3 10 3.6 COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC 10.1038/s41467-023-40064-9
1765 3817 None 60 Human Binding pAC50 = 7.0 7.0 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 522 10 4 11 2.0 CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO 10.1038/s41467-023-40064-9
4184 3817 None 60 Human Binding pAC50 = 7.0 7.0 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 522 10 4 11 2.0 CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO 10.1038/s41467-023-40064-9
9871419 3817 None 60 Human Binding pAC50 = 7.0 7.0 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 522 10 4 11 2.0 CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO 10.1038/s41467-023-40064-9
9871419.0 3817 None 60 Human Binding pAC50 = 7.0 7.0 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 522 10 4 11 2.0 CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO 10.1038/s41467-023-40064-9
CHEMBL398435 3817 None 60 Human Binding pAC50 = 7.0 7.0 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 522 10 4 11 2.0 CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO 10.1038/s41467-023-40064-9
DB08816 3817 None 60 Human Binding pAC50 = 7.0 7.0 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 522 10 4 11 2.0 CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO 10.1038/s41467-023-40064-9
3607 36392 None 50 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 339 12 1 3 4.7 CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 10.1038/s41467-023-40064-9
CHEMBL144673 36392 None 50 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 339 12 1 3 4.7 CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 10.1038/s41467-023-40064-9
100 3805 None 44 Human Binding pAC50 = 5.0 5.0 - 55
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
2637 3805 None 44 Human Binding pAC50 = 5.0 5.0 - 55
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
5452 3805 None 44 Human Binding pAC50 = 5.0 5.0 - 55
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
CHEMBL479 3805 None 44 Human Binding pAC50 = 5.0 5.0 - 55
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
DB00679 3805 None 44 Human Binding pAC50 = 5.0 5.0 - 55
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
216237 3843 None 51 Human Binding pAC50 = 5.0 5.0 - 8
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1038/s41467-023-40064-9
216237.0 3843 None 51 Human Binding pAC50 = 5.0 5.0 - 8
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1038/s41467-023-40064-9
2226 3843 None 51 Human Binding pAC50 = 5.0 5.0 - 8
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1038/s41467-023-40064-9
4110 3843 None 51 Human Binding pAC50 = 5.0 5.0 - 8
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1038/s41467-023-40064-9
443894 3843 None 51 Human Binding pAC50 = 5.0 5.0 - 8
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1038/s41467-023-40064-9
443894.0 3843 None 51 Human Binding pAC50 = 5.0 5.0 - 8
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1038/s41467-023-40064-9
CHEMBL344159 3843 None 51 Human Binding pAC50 = 5.0 5.0 - 8
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1038/s41467-023-40064-9
DB06212 3843 None 51 Human Binding pAC50 = 5.0 5.0 - 8
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.1038/s41467-023-40064-9
6540478 14453 None 25 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 2 1 4 4.7 C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C/C(=N/O)CC[C@@H]4[C@H]3CC[C@@]21CC 10.1038/s41467-023-40064-9
CHEMBL1200934 14453 None 25 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 2 1 4 4.7 C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C/C(=N/O)CC[C@@H]4[C@H]3CC[C@@]21CC 10.1038/s41467-023-40064-9
25201348 55968 None 58 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 777 5 3 4 4.6 N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O 10.1038/s41467-023-40064-9
5819 55968 None 58 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 777 5 3 4 4.6 N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL1624 55968 None 58 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 777 5 3 4 4.6 N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O 10.1038/s41467-023-40064-9
445643 97442 None 46 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 803 7 3 12 4.6 C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC 10.1038/s41467-023-40064-9
CHEMBL269732 97442 None 46 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 803 7 3 12 4.6 C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC 10.1038/s41467-023-40064-9
135565674 195116 None 61 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 627 15 3 10 5.8 CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 10.1038/s41467-023-40064-9
213023 195116 None 61 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 627 15 3 10 5.8 CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 10.1038/s41467-023-40064-9
6445226 195116 None 61 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 627 15 3 10 5.8 CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 10.1038/s41467-023-40064-9
9578572 195116 None 61 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 627 15 3 10 5.8 CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 10.1038/s41467-023-40064-9
CHEMBL539697 195116 None 61 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 627 15 3 10 5.8 CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 10.1038/s41467-023-40064-9
2799 39807 None 44 Human Binding pAC50 = 6.0 6.0 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 364 4 1 1 7.0 CC(C)(C)CC(C)(C)c1ccc(O)c(Cc2ccc(Cl)cc2Cl)c1 10.1038/s41467-023-40064-9
CHEMBL1476605 39807 None 44 Human Binding pAC50 = 6.0 6.0 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 364 4 1 1 7.0 CC(C)(C)CC(C)(C)c1ccc(O)c(Cc2ccc(Cl)cc2Cl)c1 10.1038/s41467-023-40064-9
16119814 56359 None 20 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 1093 23 16 18 -3.3 CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O 10.1038/s41467-023-40064-9
CHEMBL1630575 56359 None 20 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 1093 23 16 18 -3.3 CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O 10.1038/s41467-023-40064-9
2274 3173 None 38 Human Binding pAC50 = 4.9 4.9 - 32
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
4917 3173 None 38 Human Binding pAC50 = 4.9 4.9 - 32
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
4917.0 3173 None 38 Human Binding pAC50 = 4.9 4.9 - 32
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
7279 3173 None 38 Human Binding pAC50 = 4.9 4.9 - 32
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
CHEMBL728 3173 None 38 Human Binding pAC50 = 4.9 4.9 - 32
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
DB00433 3173 None 38 Human Binding pAC50 = 4.9 4.9 - 32
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
2855 4132 None 63 Human Binding pAC50 = 4.9 4.9 -53 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
3322 4132 None 63 Human Binding pAC50 = 4.9 4.9 -53 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
5717 4132 None 63 Human Binding pAC50 = 4.9 4.9 -53 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
5717.0 4132 None 63 Human Binding pAC50 = 4.9 4.9 -53 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
CHEMBL603 4132 None 63 Human Binding pAC50 = 4.9 4.9 -53 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
DB00549 4132 None 63 Human Binding pAC50 = 4.9 4.9 -53 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
477468 175502 None 22 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 1269 18 16 23 -3.9 CCCCCOc1ccc(-c2cc(-c3ccc(C(=O)N[C@H]4C[C@@H](O)[C@@H](O)NC(=O)[C@@H]5[C@@H](O)[C@@H](C)CN5C(=O)[C@H]([C@H](O)CC(N)=O)NC(=O)[C@H]([C@H](O)[C@@H](O)c5ccc(O)c(OS(=O)(=O)O)c5)NC(=O)[C@@H]5C[C@@H](O)CN5C(=O)[C@H]([C@@H](C)O)NC4=O)cc3)no2)cc1 10.1038/s41467-023-40064-9
CHEMBL457547 175502 None 22 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 1269 18 16 23 -3.9 CCCCCOc1ccc(-c2cc(-c3ccc(C(=O)N[C@H]4C[C@@H](O)[C@@H](O)NC(=O)[C@@H]5[C@@H](O)[C@@H](C)CN5C(=O)[C@H]([C@H](O)CC(N)=O)NC(=O)[C@H]([C@H](O)[C@@H](O)c5ccc(O)c(OS(=O)(=O)O)c5)NC(=O)[C@@H]5C[C@@H](O)CN5C(=O)[C@H]([C@@H](C)O)NC4=O)cc3)no2)cc1 10.1038/s41467-023-40064-9
2880 98061 None 34 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 310 5 0 3 4.6 C=C(c1ccccc1OCc1cccc(Cl)c1)n1ccnc1 10.1038/s41467-023-40064-9
CHEMBL27289 98061 None 34 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 310 5 0 3 4.6 C=C(c1ccccc1OCc1cccc(Cl)c1)n1ccnc1 10.1038/s41467-023-40064-9
54897 196925 None 42 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 403 7 0 3 5.5 CCCN(CCC)C(=O)Cc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12 10.1038/s41467-023-40064-9
CHEMBL54349 196925 None 42 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 403 7 0 3 5.5 CCCN(CCC)C(=O)Cc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12 10.1038/s41467-023-40064-9
5280531 58121 None 47 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 524 20 0 2 11.5 CCCCCCCCCCCCCCCC(=O)OC/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C 10.1038/s41467-023-40064-9
CHEMBL1675 58121 None 47 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 524 20 0 2 11.5 CCCCCCCCCCCCCCCC(=O)OC/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C 10.1038/s41467-023-40064-9
1155 1629 None 38 Human Binding pAC50 = 4.9 4.9 - 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1038/s41467-023-40064-9
3343 1629 None 38 Human Binding pAC50 = 4.9 4.9 - 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1038/s41467-023-40064-9
557 1629 None 38 Human Binding pAC50 = 4.9 4.9 - 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1038/s41467-023-40064-9
CHEMBL32800 1629 None 38 Human Binding pAC50 = 4.9 4.9 - 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1038/s41467-023-40064-9
DB01288 1629 None 38 Human Binding pAC50 = 4.9 4.9 - 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1038/s41467-023-40064-9
CHEMBL4743867 216518 None 10 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL None None None OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1 10.1038/s41467-023-40064-9
1890 2759 None 31 Human Binding pAC50 = 4.9 4.9 - 26
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
4449 2759 None 31 Human Binding pAC50 = 4.9 4.9 - 26
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
7247 2759 None 31 Human Binding pAC50 = 4.9 4.9 - 26
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
CHEMBL623 2759 None 31 Human Binding pAC50 = 4.9 4.9 - 26
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
DB01149 2759 None 31 Human Binding pAC50 = 4.9 4.9 - 26
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
4659569 22338 None 65 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 273 3 2 5 2.5 Cc1ccc(C(=O)c2cc(O)c(O)c([N+](=O)[O-])c2)cc1 10.1038/s41467-023-40064-9
CHEMBL1324 22338 None 65 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 273 3 2 5 2.5 Cc1ccc(C(=O)c2cc(O)c(O)c([N+](=O)[O-])c2)cc1 10.1038/s41467-023-40064-9
71731823 111768 None 45 Human Binding pAC50 = 5.9 5.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 0 1 7 2.8 C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21 10.1038/s41467-023-40064-9
CHEMBL3286830 111768 None 45 Human Binding pAC50 = 5.9 5.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 0 1 7 2.8 C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21 10.1038/s41467-023-40064-9
3292 8623 None 37 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 204 2 1 2 1.3 CCN1C(=O)NC(c2ccccc2)C1=O 10.1038/s41467-023-40064-9
CHEMBL1095 8623 None 37 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 204 2 1 2 1.3 CCN1C(=O)NC(c2ccccc2)C1=O 10.1038/s41467-023-40064-9
5288783 14438 None 36 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 5 3 3 5.1 C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)/C=C/[C@@H](O)C4CC4)CC[C@@H]23)C[C@@H](O)C[C@@H]1O 10.1038/s41467-023-40064-9
CHEMBL1200666 14438 None 36 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 5 3 3 5.1 C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)/C=C/[C@@H](O)C4CC4)CC[C@@H]23)C[C@@H](O)C[C@@H]1O 10.1038/s41467-023-40064-9
610479 15507 None 60 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 261 3 2 2 4.1 Cc1c(Cl)cccc1Nc1ccccc1C(=O)O 10.1038/s41467-023-40064-9
CHEMBL121626 15507 None 60 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 261 3 2 2 4.1 Cc1c(Cl)cccc1Nc1ccccc1C(=O)O 10.1038/s41467-023-40064-9
5282181 53539 None 37 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 400 6 2 2 6.6 C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]23)C[C@@H](O)C[C@@H]1O 10.1038/s41467-023-40064-9
CHEMBL1601669 53539 None 37 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 400 6 2 2 6.6 C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]23)C[C@@H](O)C[C@@H]1O 10.1038/s41467-023-40064-9
67462786 120581 None 50 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 446 9 1 8 4.2 COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 10.1038/s41467-023-40064-9
CHEMBL3545376 120581 None 50 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 446 9 1 8 4.2 COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 10.1038/s41467-023-40064-9
55483 207555 None 29 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 356 13 4 4 3.6 Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O 10.1038/s41467-023-40064-9
CHEMBL77622 207555 None 29 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 356 13 4 4 3.6 Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O 10.1038/s41467-023-40064-9
54260 186945 None 28 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 317 6 0 2 4.7 CCC(C)(C)c1ccc(CC(C)CN2C[C@@H](C)O[C@@H](C)C2)cc1 10.1038/s41467-023-40064-9
CHEMBL489411 186945 None 28 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 317 6 0 2 4.7 CCC(C)(C)c1ccc(CC(C)CN2C[C@@H](C)O[C@@H](C)C2)cc1 10.1038/s41467-023-40064-9
1054 2917 None 55 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 282 15 1 1 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)O 10.1038/s41467-023-40064-9
3400 2917 None 55 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 282 15 1 1 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)O 10.1038/s41467-023-40064-9
445639 2917 None 55 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 282 15 1 1 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)O 10.1038/s41467-023-40064-9
CHEMBL8659 2917 None 55 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 282 15 1 1 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)O 10.1038/s41467-023-40064-9
54454 5260 None 48 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 418 6 1 5 4.6 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
CHEMBL1064 5260 None 48 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 418 6 1 5 4.6 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
11057 176253 None 16 Human Binding pAC50 = 5.9 5.9 -3 20
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 10.1038/s41467-023-40064-9
3468 176253 None 16 Human Binding pAC50 = 5.9 5.9 -3 20
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 10.1038/s41467-023-40064-9
CHEMBL459265 176253 None 16 Human Binding pAC50 = 5.9 5.9 -3 20
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 10.1038/s41467-023-40064-9
CHEMBL64894 176253 None 16 Human Binding pAC50 = 5.9 5.9 -3 20
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 10.1038/s41467-023-40064-9
10180 98923 None 36 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 340 6 1 4 4.5 CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12 10.1038/s41467-023-40064-9
CHEMBL279014 98923 None 36 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 340 6 1 4 4.5 CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12 10.1038/s41467-023-40064-9
135400189 44589 None 42 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 488 8 1 8 2.1 CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12 10.1038/s41467-023-40064-9
CHEMBL1520 44589 None 42 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 488 8 1 8 2.1 CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12 10.1038/s41467-023-40064-9
4150 788 None 26 Human Binding pAC50 = 4.9 4.9 - 12
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1038/s41467-023-40064-9
5288 788 None 26 Human Binding pAC50 = 4.9 4.9 - 12
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1038/s41467-023-40064-9
644019 788 None 26 Human Binding pAC50 = 4.9 4.9 - 12
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1038/s41467-023-40064-9
644019.0 788 None 26 Human Binding pAC50 = 4.9 4.9 - 12
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1038/s41467-023-40064-9
CHEMBL190461 788 None 26 Human Binding pAC50 = 4.9 4.9 - 12
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1038/s41467-023-40064-9
DB09061 788 None 26 Human Binding pAC50 = 4.9 4.9 - 12
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1038/s41467-023-40064-9
8730 198347 None 44 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 777 5 3 4 4.6 N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O 10.1038/s41467-023-40064-9
90657408 198347 None 44 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 777 5 3 4 4.6 N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL559 198347 None 44 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 777 5 3 4 4.6 N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O 10.1038/s41467-023-40064-9
4046 2483 None 21 Human Binding pAC50 = 4.9 4.9 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
4252 2483 None 21 Human Binding pAC50 = 4.9 4.9 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
CHEMBL416956 2483 None 21 Human Binding pAC50 = 4.9 4.9 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
DB00358 2483 None 21 Human Binding pAC50 = 4.9 4.9 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
24765256 173401 None 21 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 757 6 3 9 3.9 CC[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1 10.1038/s41467-023-40064-9
CHEMBL4525964 173401 None 21 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 757 6 3 9 3.9 CC[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1 10.1038/s41467-023-40064-9
9823820 19173 None 64 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 426 6 3 5 4.1 COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O 10.1038/s41467-023-40064-9
CHEMBL1289601 19173 None 64 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 426 6 3 5 4.1 COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O 10.1038/s41467-023-40064-9
12628 105688 None 25 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 296 3 2 3 2.3 Cc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1 10.1038/s41467-023-40064-9
CHEMBL312394 105688 None 25 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 296 3 2 3 2.3 Cc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1 10.1038/s41467-023-40064-9
57363 206695 None 54 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 372 1 2 2 3.8 CC(C)(C)NC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4NC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C 10.1038/s41467-023-40064-9
CHEMBL710 206695 None 54 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 372 1 2 2 3.8 CC(C)(C)NC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4NC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C 10.1038/s41467-023-40064-9
3760 50314 None 27 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 414 6 0 3 6.5 Clc1ccc(C(Cn2ccnc2)OCc2c(Cl)cccc2Cl)c(Cl)c1 10.1038/s41467-023-40064-9
CHEMBL1571863 50314 None 27 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 414 6 0 3 6.5 Clc1ccc(C(Cn2ccnc2)OCc2c(Cl)cccc2Cl)c(Cl)c1 10.1038/s41467-023-40064-9
5284535 59128 None 24 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 2 3 5 1.9 C[C@]12C=CC(=O)C=C1C(Cl)=C[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO 10.1038/s41467-023-40064-9
CHEMBL1697832 59128 None 24 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 2 3 5 1.9 C[C@]12C=CC(=O)C=C1C(Cl)=C[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO 10.1038/s41467-023-40064-9
6436173 55132 None 30 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 785 2 5 13 6.2 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL1617 55132 None 30 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 785 2 5 13 6.2 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
2351 4301 None 35 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 10.1038/s41467-023-40064-9
CHEMBL1008 4301 None 35 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 10.1038/s41467-023-40064-9
CHEMBL1257078 4301 None 35 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 10.1038/s41467-023-40064-9
5353627 84575 None 8 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 411 8 3 4 4.6 CC(C)n1c(/C=C/C(O)CC(O)CC(=O)O)c(-c2ccc(F)cc2)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL2220442 84575 None 8 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 411 8 3 4 4.6 CC(C)n1c(/C=C/C(O)CC(O)CC(=O)O)c(-c2ccc(F)cc2)c2ccccc21 10.1038/s41467-023-40064-9
4236 28104 None 33 Human Binding pAC50 = 4.9 4.9 - 1
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 273 5 1 2 2.0 NC(=O)C[S+]([O-])C(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1373 28104 None 33 Human Binding pAC50 = 4.9 4.9 - 1
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 273 5 1 2 2.0 NC(=O)C[S+]([O-])C(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
4046 2483 None 21 Human Binding pAC50 = 4.9 4.9 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
4252 2483 None 21 Human Binding pAC50 = 4.9 4.9 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
CHEMBL416956 2483 None 21 Human Binding pAC50 = 4.9 4.9 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
DB00358 2483 None 21 Human Binding pAC50 = 4.9 4.9 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
5991 206377 None 46 Human Binding pAC50 = 4.9 4.9 -50 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 296 0 2 2 3.6 C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL691 206377 None 46 Human Binding pAC50 = 4.9 4.9 -50 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 296 0 2 2 3.6 C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
4055 201689 None 70 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 172 0 0 2 2.0 CC1=CC(=O)c2ccccc2C1=O 10.1038/s41467-023-40064-9
CHEMBL590 201689 None 70 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 172 0 0 2 2.0 CC1=CC(=O)c2ccccc2C1=O 10.1038/s41467-023-40064-9
10124 78304 None 14 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 255 2 2 6 1.1 Nc1ccc(S(=O)(=O)c2cnc(N)s2)cc1 10.1038/s41467-023-40064-9
CHEMBL2107139 78304 None 14 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 255 2 2 6 1.1 Nc1ccc(S(=O)(=O)c2cnc(N)s2)cc1 10.1038/s41467-023-40064-9
6436135 99626 None 31 Human Binding pAC50 = 4.9 4.9 - 1
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 9 2 4 5.8 CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL283754 99626 None 31 Human Binding pAC50 = 4.9 4.9 - 1
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 9 2 4 5.8 CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O 10.1038/s41467-023-40064-9
11304743 78326 None 65 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 422 4 2 9 2.4 COC(=O)N(C)c1c(N)nc(-c2nn(Cc3ccccc3F)c3ncccc23)nc1N 10.1038/s41467-023-40064-9
CHEMBL2107834 78326 None 65 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 422 4 2 9 2.4 COC(=O)N(C)c1c(N)nc(-c2nn(Cc3ccccc3F)c3ncccc23)nc1N 10.1038/s41467-023-40064-9
667492 43919 None 36 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 234 1 2 3 0.2 CN1C(=O)/C(=N\NC(N)=S)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL1512080 43919 None 36 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 234 1 2 3 0.2 CN1C(=O)/C(=N\NC(N)=S)c2ccccc21 10.1038/s41467-023-40064-9
3474 38112 None 43 Human Binding pAC50 = 5.9 5.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 372 6 3 6 3.1 O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12 10.1038/s41467-023-40064-9
CHEMBL146095 38112 None 43 Human Binding pAC50 = 5.9 5.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 372 6 3 6 3.1 O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12 10.1038/s41467-023-40064-9
196122 112651 None 39 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 478 13 1 6 4.5 CCOC1O[C@H]([C@@H](COCc2ccccc2)OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1O 10.1038/s41467-023-40064-9
CHEMBL3301681 112651 None 39 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 478 13 1 6 4.5 CCOC1O[C@H]([C@@H](COCc2ccccc2)OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1O 10.1038/s41467-023-40064-9
4195 14477 None 34 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 254 6 3 5 -0.2 COc1ccc(OC)c(C(O)CNC(=O)CN)c1 10.1038/s41467-023-40064-9
4195.0 14477 None 34 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 254 6 3 5 -0.2 COc1ccc(OC)c(C(O)CNC(=O)CN)c1 10.1038/s41467-023-40064-9
CHEMBL1201212 14477 None 34 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 254 6 3 5 -0.2 COc1ccc(OC)c(C(O)CNC(=O)CN)c1 10.1038/s41467-023-40064-9
DB00211 14477 None 34 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 254 6 3 5 -0.2 COc1ccc(OC)c(C(O)CNC(=O)CN)c1 10.1038/s41467-023-40064-9
3926 209699 None 30 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 491 9 1 3 5.8 Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1038/s41467-023-40064-9
CHEMBL92870 209699 None 30 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 491 9 1 3 5.8 Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1038/s41467-023-40064-9
102 4127 None 36 Human Binding pAC50 = 4.9 4.9 - 50
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1038/s41467-023-40064-9
3659 4127 None 36 Human Binding pAC50 = 4.9 4.9 - 50
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1038/s41467-023-40064-9
8969 4127 None 36 Human Binding pAC50 = 4.9 4.9 - 50
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1038/s41467-023-40064-9
8969.0 4127 None 36 Human Binding pAC50 = 4.9 4.9 - 50
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1038/s41467-023-40064-9
CHEMBL15245 4127 None 36 Human Binding pAC50 = 4.9 4.9 - 50
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1038/s41467-023-40064-9
DB01392 4127 None 36 Human Binding pAC50 = 4.9 4.9 - 50
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1038/s41467-023-40064-9
49806720 60100 None 66 Human Binding pAC50 = 5.9 5.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 482 3 1 5 4.8 CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O 10.1038/s41467-023-40064-9
CHEMBL1738797 60100 None 66 Human Binding pAC50 = 5.9 5.9 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 482 3 1 5 4.8 CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O 10.1038/s41467-023-40064-9
4746 207349 None 24 Human Binding pAC50 = 4.9 4.9 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 4 1 1 5.3 C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1 10.1038/s41467-023-40064-9
CHEMBL1334033 207349 None 24 Human Binding pAC50 = 4.9 4.9 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 4 1 1 5.3 C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1 10.1038/s41467-023-40064-9
CHEMBL75880 207349 None 24 Human Binding pAC50 = 4.9 4.9 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 4 1 1 5.3 C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1 10.1038/s41467-023-40064-9
191 403 None 60 Human Binding pAC50 = 4.9 4.9 - 28
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
201 403 None 60 Human Binding pAC50 = 4.9 4.9 - 28
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
2170 403 None 60 Human Binding pAC50 = 4.9 4.9 - 28
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
2170.0 403 None 60 Human Binding pAC50 = 4.9 4.9 - 28
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
CHEMBL1113 403 None 60 Human Binding pAC50 = 4.9 4.9 - 28
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
DB00543 403 None 60 Human Binding pAC50 = 4.9 4.9 - 28
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
180 401 None 38 Human Binding pAC50 = 4.9 4.9 - 39
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
200 401 None 38 Human Binding pAC50 = 4.9 4.9 - 39
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
2160 401 None 38 Human Binding pAC50 = 4.9 4.9 - 39
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
2160.0 401 None 38 Human Binding pAC50 = 4.9 4.9 - 39
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
CHEMBL629 401 None 38 Human Binding pAC50 = 4.9 4.9 - 39
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
DB00321 401 None 38 Human Binding pAC50 = 4.9 4.9 - 39
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
1016 3747 None 45 Human Binding pAC50 = 4.9 4.9 -21 35
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
2561 3747 None 45 Human Binding pAC50 = 4.9 4.9 -21 35
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
2733526 3747 None 45 Human Binding pAC50 = 4.9 4.9 -21 35
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
5384 3747 None 45 Human Binding pAC50 = 4.9 4.9 -21 35
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL83 3747 None 45 Human Binding pAC50 = 4.9 4.9 -21 35
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
DB00675 3747 None 45 Human Binding pAC50 = 4.9 4.9 -21 35
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
4046 2483 None 21 Human Binding pAC50 = 4.8 4.8 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
4252 2483 None 21 Human Binding pAC50 = 4.8 4.8 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
CHEMBL416956 2483 None 21 Human Binding pAC50 = 4.8 4.8 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
DB00358 2483 None 21 Human Binding pAC50 = 4.8 4.8 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
135412795 44765 None 17 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 296 1 1 3 3.4 O=C1CN=C(c2ccccc2)c2c(sc3c2CCCC3)N1 10.1038/s41467-023-40064-9
CHEMBL1521495 44765 None 17 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 296 1 1 3 3.4 O=C1CN=C(c2ccccc2)c2c(sc3c2CCCC3)N1 10.1038/s41467-023-40064-9
60663 175773 None 30 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 495 11 1 5 5.3 COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C 10.1038/s41467-023-40064-9
CHEMBL1421212 175773 None 30 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 495 11 1 5 5.3 COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C 10.1038/s41467-023-40064-9
CHEMBL1534525 175773 None 30 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 495 11 1 5 5.3 COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C 10.1038/s41467-023-40064-9
CHEMBL45816 175773 None 30 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 495 11 1 5 5.3 COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C 10.1038/s41467-023-40064-9
124246 78318 None 60 Human Binding pAC50 = 5.8 5.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 374 6 2 6 2.5 CS(=O)(=O)Nc1cc2occ(NC=O)c(=O)c2cc1Oc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL2107455 78318 None 60 Human Binding pAC50 = 5.8 5.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 374 6 2 6 2.5 CS(=O)(=O)Nc1cc2occ(NC=O)c(=O)c2cc1Oc1ccccc1 10.1038/s41467-023-40064-9
38945 60836 None 44 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 192 2 2 2 1.6 Cc1cccc(C)c1NC(=O)C(C)N 10.1038/s41467-023-40064-9
CHEMBL1762 60836 None 44 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 192 2 2 2 1.6 Cc1cccc(C)c1NC(=O)C(C)N 10.1038/s41467-023-40064-9
5472 208276 None 49 Human Binding pAC50 = 4.8 4.8 - 3
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1 10.1038/s41467-023-40064-9
5472.0 208276 None 49 Human Binding pAC50 = 4.8 4.8 - 3
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1 10.1038/s41467-023-40064-9
CHEMBL1717 208276 None 49 Human Binding pAC50 = 4.8 4.8 - 3
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1 10.1038/s41467-023-40064-9
CHEMBL833 208276 None 49 Human Binding pAC50 = 4.8 4.8 - 3
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1 10.1038/s41467-023-40064-9
DB00208 208276 None 49 Human Binding pAC50 = 4.8 4.8 - 3
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1 10.1038/s41467-023-40064-9
3117 210300 None 60 Human Binding pAC50 = 5.8 5.8 1 16
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 296 4 0 4 3.6 CCN(CC)C(=S)SSC(=S)N(CC)CC 10.1038/s41467-023-40064-9
CHEMBL964 210300 None 60 Human Binding pAC50 = 5.8 5.8 1 16
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 296 4 0 4 3.6 CCN(CC)C(=S)SSC(=S)N(CC)CC 10.1038/s41467-023-40064-9
119584 2595 None 61 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl 10.1038/s41467-023-40064-9
119584.0 2595 None 61 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl 10.1038/s41467-023-40064-9
1848 2595 None 61 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl 10.1038/s41467-023-40064-9
242 2595 None 61 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl 10.1038/s41467-023-40064-9
CHEMBL60889 2595 None 61 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl 10.1038/s41467-023-40064-9
DB11675 2595 None 61 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 421 7 2 5 3.1 CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl 10.1038/s41467-023-40064-9
4908 188914 None 51 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 259 6 2 4 2.8 COc1cc(NC(C)CCCN)c2ncccc2c1 10.1038/s41467-023-40064-9
CHEMBL506 188914 None 51 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 259 6 2 4 2.8 COc1cc(NC(C)CCCN)c2ncccc2c1 10.1038/s41467-023-40064-9
2200 20210 None 38 Human Binding pAC50 = 4.8 4.8 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 265 5 1 3 2.7 c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 10.1038/s41467-023-40064-9
2200.0 20210 None 38 Human Binding pAC50 = 4.8 4.8 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 265 5 1 3 2.7 c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL1256819 20210 None 38 Human Binding pAC50 = 4.8 4.8 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 265 5 1 3 2.7 c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL1305 20210 None 38 Human Binding pAC50 = 4.8 4.8 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 265 5 1 3 2.7 c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 10.1038/s41467-023-40064-9
DB08799 20210 None 38 Human Binding pAC50 = 4.8 4.8 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 265 5 1 3 2.7 c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 10.1038/s41467-023-40064-9
5280795 4831 None 53 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 384 6 1 1 7.6 C=C1CC[C@H](O)C/C1=C/C=C1\CCC[C@]2(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]12 10.1038/s41467-023-40064-9
CHEMBL1042 4831 None 53 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 384 6 1 1 7.6 C=C1CC[C@H](O)C/C1=C/C=C1\CCC[C@]2(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]12 10.1038/s41467-023-40064-9
71226662 133575 None 53 Human Binding pAC50 = 5.8 5.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 465 4 2 7 3.3 CC#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(C(=O)Nc3ccccn3)cc2)c2c(N)nccn12 10.1038/s41467-023-40064-9
CHEMBL3707348 133575 None 53 Human Binding pAC50 = 5.8 5.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 465 4 2 7 3.3 CC#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(C(=O)Nc3ccccn3)cc2)c2c(N)nccn12 10.1038/s41467-023-40064-9
60151560 167540 None 37 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 439 11 1 5 5.3 CCO[C@@H](Cc1ccc(OCCn2c(C)ccc2-c2ccc(SC)cc2)cc1)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL4297530 167540 None 37 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 439 11 1 5 5.3 CCO[C@@H](Cc1ccc(OCCn2c(C)ccc2-c2ccc(SC)cc2)cc1)C(=O)O 10.1038/s41467-023-40064-9
1385580 29284 None 49 Human Binding pAC50 = 4.8 4.8 - 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
4615 29284 None 49 Human Binding pAC50 = 4.8 4.8 - 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
4615.0 29284 None 49 Human Binding pAC50 = 4.8 4.8 - 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
CHEMBL13828 29284 None 49 Human Binding pAC50 = 4.8 4.8 - 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
DB12877 29284 None 49 Human Binding pAC50 = 4.8 4.8 - 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
16678941 78182 None 61 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 452 5 2 5 4.7 Cc1ccc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)nc1-c1cccc(C(=O)O)c1 10.1038/s41467-023-40064-9
CHEMBL2103870 78182 None 61 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 452 5 2 5 4.7 Cc1ccc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)nc1-c1cccc(C(=O)O)c1 10.1038/s41467-023-40064-9
3401 78314 None 52 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 346 4 0 2 5.0 Fc1ccc(C(c2ccccc2)(c2ccccc2F)n2ccnc2)cc1 10.1038/s41467-023-40064-9
CHEMBL2107430 78314 None 52 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 346 4 0 2 5.0 Fc1ccc(C(c2ccccc2)(c2ccccc2F)n2ccnc2)cc1 10.1038/s41467-023-40064-9
4041 99565 None 9 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 270 1 0 2 3.6 CN1CCN=C(c2ccccc2)c2cc(Cl)ccc21 10.1038/s41467-023-40064-9
CHEMBL28333 99565 None 9 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 270 1 0 2 3.6 CN1CCN=C(c2ccccc2)c2cc(Cl)ccc21 10.1038/s41467-023-40064-9
107771 120312 None 42 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 517 7 2 7 6.1 COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1 10.1038/s41467-023-40064-9
CHEMBL35228 120312 None 42 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 517 7 2 7 6.1 COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1 10.1038/s41467-023-40064-9
5311217 176845 None 55 Human Binding pAC50 = 4.8 4.8 -1 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 455 7 1 7 4.4 CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1c1ccccc1/C=C/C(=O)OC(C)(C)C 10.1038/s41467-023-40064-9
CHEMBL460291 176845 None 55 Human Binding pAC50 = 4.8 4.8 -1 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 455 7 1 7 4.4 CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1c1ccccc1/C=C/C(=O)OC(C)(C)C 10.1038/s41467-023-40064-9
1212 1662 None 37 Human Binding pAC50 = 4.8 4.8 -371 65
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
204 1662 None 37 Human Binding pAC50 = 4.8 4.8 -371 65
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
3372 1662 None 37 Human Binding pAC50 = 4.8 4.8 -371 65
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
3372.0 1662 None 37 Human Binding pAC50 = 4.8 4.8 -371 65
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL726 1662 None 37 Human Binding pAC50 = 4.8 4.8 -371 65
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
DB00623 1662 None 37 Human Binding pAC50 = 4.8 4.8 -371 65
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
135409453 3773 None 26 Human Binding pAC50 = 4.8 4.8 - 19
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
226 3773 None 26 Human Binding pAC50 = 4.8 4.8 - 19
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
CHEMBL76370 3773 None 26 Human Binding pAC50 = 4.8 4.8 - 19
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
208898 66220 None 50 Human Binding pAC50 = 5.8 5.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 556 18 1 6 7.0 CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1 10.1038/s41467-023-40064-9
208898.0 66220 None 50 Human Binding pAC50 = 5.8 5.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 556 18 1 6 7.0 CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1 10.1038/s41467-023-40064-9
CHEMBL184412 66220 None 50 Human Binding pAC50 = 5.8 5.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 556 18 1 6 7.0 CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1 10.1038/s41467-023-40064-9
DB04855 66220 None 50 Human Binding pAC50 = 5.8 5.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 556 18 1 6 7.0 CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1 10.1038/s41467-023-40064-9
2600 3779 None 53 Human Binding pAC50 = 4.8 4.8 - 13
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
2608 3779 None 53 Human Binding pAC50 = 4.8 4.8 - 13
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
5405 3779 None 53 Human Binding pAC50 = 4.8 4.8 - 13
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
CHEMBL17157 3779 None 53 Human Binding pAC50 = 4.8 4.8 - 13
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
DB00342 3779 None 53 Human Binding pAC50 = 4.8 4.8 - 13
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
5022 1651 None 58 Human Binding pAC50 = 4.8 4.8 - 9
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 390 4 1 4 3.2 O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2 10.1038/s41467-023-40064-9
6918248 1651 None 58 Human Binding pAC50 = 4.8 4.8 - 9
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 390 4 1 4 3.2 O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2 10.1038/s41467-023-40064-9
6918248.0 1651 None 58 Human Binding pAC50 = 4.8 4.8 - 9
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 390 4 1 4 3.2 O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2 10.1038/s41467-023-40064-9
8182 1651 None 58 Human Binding pAC50 = 4.8 4.8 - 9
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 390 4 1 4 3.2 O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2 10.1038/s41467-023-40064-9
CHEMBL231068 1651 None 58 Human Binding pAC50 = 4.8 4.8 - 9
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 390 4 1 4 3.2 O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2 10.1038/s41467-023-40064-9
DB04908 1651 None 58 Human Binding pAC50 = 4.8 4.8 - 9
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 390 4 1 4 3.2 O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2 10.1038/s41467-023-40064-9
9801 91619 None 25 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 329 8 1 1 5.4 CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL24072 91619 None 25 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 329 8 1 1 5.4 CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL508338 189074 None 0 Human Binding pAC50 = 5.8 5.8 -66 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL None None None None 10.1038/s41467-023-40064-9
3339 206099 None 69 Human Binding pAC50 = 4.8 4.8 -2 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 360 6 0 4 4.7 CC(C)OC(=O)C(C)(C)Oc1ccc(C(=O)c2ccc(Cl)cc2)cc1 10.1038/s41467-023-40064-9
CHEMBL672 206099 None 69 Human Binding pAC50 = 4.8 4.8 -2 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 360 6 0 4 4.7 CC(C)OC(=O)C(C)(C)Oc1ccc(C(=O)c2ccc(Cl)cc2)cc1 10.1038/s41467-023-40064-9
8550 14429 None 40 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 578 7 1 9 4.2 COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5ccccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC 10.1038/s41467-023-40064-9
CHEMBL1200515 14429 None 40 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 578 7 1 9 4.2 COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5ccccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC 10.1038/s41467-023-40064-9
3673 78268 None 49 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 297 6 0 3 4.1 CC(C)Cc1ccc(C(C)C(=O)OCc2ccccn2)cc1 10.1038/s41467-023-40064-9
CHEMBL2106254 78268 None 49 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 297 6 0 3 4.1 CC(C)Cc1ccc(C(C)C(=O)OCc2ccccn2)cc1 10.1038/s41467-023-40064-9
2142 3096 None 36 Human Binding pAC50 = 4.8 4.8 - 36
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
4920903 3096 None 36 Human Binding pAC50 = 4.8 4.8 - 36
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
502 3096 None 36 Human Binding pAC50 = 4.8 4.8 - 36
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
5775 3096 None 36 Human Binding pAC50 = 4.8 4.8 - 36
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
5775.0 3096 None 36 Human Binding pAC50 = 4.8 4.8 - 36
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
CHEMBL597 3096 None 36 Human Binding pAC50 = 4.8 4.8 - 36
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
DB00692 3096 None 36 Human Binding pAC50 = 4.8 4.8 - 36
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
1935 3734 None 62 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 198 0 1 2 2.7 Nc1c2CCCCc2nc2c1cccc2 10.1038/s41467-023-40064-9
2551 3734 None 62 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 198 0 1 2 2.7 Nc1c2CCCCc2nc2c1cccc2 10.1038/s41467-023-40064-9
6687 3734 None 62 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 198 0 1 2 2.7 Nc1c2CCCCc2nc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL95 3734 None 62 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 198 0 1 2 2.7 Nc1c2CCCCc2nc2c1cccc2 10.1038/s41467-023-40064-9
DB00382 3734 None 62 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 198 0 1 2 2.7 Nc1c2CCCCc2nc2c1cccc2 10.1038/s41467-023-40064-9
2435 3590 None 59 Human Binding pAC50 = 4.8 4.8 - 48
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
60149 3590 None 59 Human Binding pAC50 = 4.8 4.8 - 48
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
98 3590 None 59 Human Binding pAC50 = 4.8 4.8 - 48
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
CHEMBL12713 3590 None 59 Human Binding pAC50 = 4.8 4.8 - 48
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
DB06144 3590 None 59 Human Binding pAC50 = 4.8 4.8 - 48
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
47472 19444 None 41 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 410 7 0 3 6.6 Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1295 19444 None 41 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 410 7 0 3 6.6 Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1 10.1038/s41467-023-40064-9
65863 14471 None 40 Human Binding pAC50 = 5.8 5.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 436 6 0 4 7.0 Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1 10.1038/s41467-023-40064-9
CHEMBL1201196 14471 None 40 Human Binding pAC50 = 5.8 5.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 436 6 0 4 7.0 Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1 10.1038/s41467-023-40064-9
441336 10257 None 47 Human Binding pAC50 = 5.8 5.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 520 4 1 6 4.9 C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c1ccco1)C(=O)CCl 10.1038/s41467-023-40064-9
CHEMBL1161 10257 None 47 Human Binding pAC50 = 5.8 5.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 520 4 1 6 4.9 C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c1ccco1)C(=O)CCl 10.1038/s41467-023-40064-9
92727 207010 None 50 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 628 15 4 5 4.3 Cc1cccc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N1CCCNC1=O 10.1038/s41467-023-40064-9
CHEMBL729 207010 None 50 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 628 15 4 5 4.3 Cc1cccc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N1CCCNC1=O 10.1038/s41467-023-40064-9
1909 2822 None 46 Human Binding pAC50 = 5.8 5.8 -1 4
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 479 9 1 8 3.7 COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C 10.1038/s41467-023-40064-9
2559 2822 None 46 Human Binding pAC50 = 5.8 5.8 -1 4
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 479 9 1 8 3.7 COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C 10.1038/s41467-023-40064-9
4474 2822 None 46 Human Binding pAC50 = 5.8 5.8 -1 4
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 479 9 1 8 3.7 COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C 10.1038/s41467-023-40064-9
CHEMBL1484 2822 None 46 Human Binding pAC50 = 5.8 5.8 -1 4
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 479 9 1 8 3.7 COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C 10.1038/s41467-023-40064-9
CHEMBL3302409 2822 None 46 Human Binding pAC50 = 5.8 5.8 -1 4
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 479 9 1 8 3.7 COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C 10.1038/s41467-023-40064-9
DB00622 2822 None 46 Human Binding pAC50 = 5.8 5.8 -1 4
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 479 9 1 8 3.7 COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C 10.1038/s41467-023-40064-9
2844 283 None 61 Human Binding pAC50 = 5.8 5.8 -4 8
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1038/s41467-023-40064-9
60961 283 None 61 Human Binding pAC50 = 5.8 5.8 -4 8
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1038/s41467-023-40064-9
60961.0 283 None 61 Human Binding pAC50 = 5.8 5.8 -4 8
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1038/s41467-023-40064-9
90 283 None 61 Human Binding pAC50 = 5.8 5.8 -4 8
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1038/s41467-023-40064-9
CHEMBL477 283 None 61 Human Binding pAC50 = 5.8 5.8 -4 8
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1038/s41467-023-40064-9
DB00640 283 None 61 Human Binding pAC50 = 5.8 5.8 -4 8
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 2 4 9 -2.0 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N 10.1038/s41467-023-40064-9
3949 100668 None 35 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 468 8 0 5 4.9 COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC 10.1038/s41467-023-40064-9
CHEMBL29188 100668 None 35 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 468 8 0 5 4.9 COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC 10.1038/s41467-023-40064-9
26248 161633 None 72 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 368 3 1 7 2.0 CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O 10.1038/s41467-023-40064-9
CHEMBL41286 161633 None 72 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 368 3 1 7 2.0 CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O 10.1038/s41467-023-40064-9
10034073 17168 None 30 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 1056 13 7 18 6.2 CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL1255800 17168 None 30 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 1056 13 7 18 6.2 CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C 10.1038/s41467-023-40064-9
34755 7735 None 43 Human Binding pAC50 = 6.8 6.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 398 7 4 11 -3.3 C[S+](CC[C@H](N)C(=O)[O-])C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O 10.1038/s41467-023-40064-9
CHEMBL1088977 7735 None 43 Human Binding pAC50 = 6.8 6.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 398 7 4 11 -3.3 C[S+](CC[C@H](N)C(=O)[O-])C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O 10.1038/s41467-023-40064-9
3547 141460 None 43 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 291 2 1 4 1.2 O=S(=O)(c1cccc2cnccc12)N1CCCNCC1 10.1038/s41467-023-40064-9
CHEMBL38380 141460 None 43 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 291 2 1 4 1.2 O=S(=O)(c1cccc2cnccc12)N1CCCNCC1 10.1038/s41467-023-40064-9
CHEMBL541388 141460 None 43 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 291 2 1 4 1.2 O=S(=O)(c1cccc2cnccc12)N1CCCNCC1 10.1038/s41467-023-40064-9
3598 187927 None 45 Human Binding pAC50 = 5.8 5.8 1 7
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl 10.1038/s41467-023-40064-9
CHEMBL496 187927 None 45 Human Binding pAC50 = 5.8 5.8 1 7
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl 10.1038/s41467-023-40064-9
54685524 78269 None 25 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 408 4 2 8 3.0 CCOC(=O)C(c1c(O)c2ccccc2oc1=O)c1c(O)c2ccccc2oc1=O 10.1038/s41467-023-40064-9
CHEMBL2106261 78269 None 25 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 408 4 2 8 3.0 CCOC(=O)C(c1c(O)c2ccccc2oc1=O)c1c(O)c2ccccc2oc1=O 10.1038/s41467-023-40064-9
2583 3776 None 69 Human Binding pAC50 = 4.8 4.8 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
592 3776 None 69 Human Binding pAC50 = 4.8 4.8 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
65999 3776 None 69 Human Binding pAC50 = 4.8 4.8 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
65999.0 3776 None 69 Human Binding pAC50 = 4.8 4.8 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
CHEMBL1017 3776 None 69 Human Binding pAC50 = 4.8 4.8 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
DB00966 3776 None 69 Human Binding pAC50 = 4.8 4.8 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
1440 2027 None 69 Human Binding pAC50 = 5.8 5.8 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 357 4 1 4 3.9 COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
1909 2027 None 69 Human Binding pAC50 = 5.8 5.8 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 357 4 1 4 3.9 COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
3715 2027 None 69 Human Binding pAC50 = 5.8 5.8 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 357 4 1 4 3.9 COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
CHEMBL6 2027 None 69 Human Binding pAC50 = 5.8 5.8 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 357 4 1 4 3.9 COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
DB00328 2027 None 69 Human Binding pAC50 = 5.8 5.8 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 357 4 1 4 3.9 COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
5770 207516 None 57 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 608 8 1 10 4.2 COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC 10.1038/s41467-023-40064-9
CHEMBL772 207516 None 57 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 608 8 1 10 4.2 COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC 10.1038/s41467-023-40064-9
3823 50235 None 31 Human Binding pAC50 = 4.8 4.8 - 11
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 10.1038/s41467-023-40064-9
76973198 50235 None 31 Human Binding pAC50 = 4.8 4.8 - 11
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 10.1038/s41467-023-40064-9
CHEMBL157101 50235 None 31 Human Binding pAC50 = 4.8 4.8 - 11
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 10.1038/s41467-023-40064-9
1028 291 None 40 Human Binding pAC50 = 4.8 4.8 - 29
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
139148732 291 None 40 Human Binding pAC50 = 4.8 4.8 - 29
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
479 291 None 40 Human Binding pAC50 = 4.8 4.8 - 29
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
5816 291 None 40 Human Binding pAC50 = 4.8 4.8 - 29
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
5816.0 291 None 40 Human Binding pAC50 = 4.8 4.8 - 29
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
CHEMBL679 291 None 40 Human Binding pAC50 = 4.8 4.8 - 29
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
DB00668 291 None 40 Human Binding pAC50 = 4.8 4.8 - 29
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
42611257 16381 None 66 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 489 7 2 4 5.5 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F 10.1038/s41467-023-40064-9
CHEMBL1229517 16381 None 66 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 489 7 2 4 5.5 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F 10.1038/s41467-023-40064-9
3599 16886 None 60 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 20 0 4 5.7 CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C 10.1038/s41467-023-40064-9
CHEMBL125 16886 None 60 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 20 0 4 5.7 CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C 10.1038/s41467-023-40064-9
9831415 77962 None 39 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 330 14 0 2 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)OCC 10.1038/s41467-023-40064-9
CHEMBL2095209 77962 None 39 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 330 14 0 2 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)OCC 10.1038/s41467-023-40064-9
3947 208853 None 39 Human Binding pAC50 = 4.8 4.8 - 15
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 418 7 0 3 5.8 CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL87708 208853 None 39 Human Binding pAC50 = 4.8 4.8 - 15
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 418 7 0 3 5.8 CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1 10.1038/s41467-023-40064-9
2754 207829 None 60 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 7 1 6 3.5 O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1 10.1038/s41467-023-40064-9
CHEMBL799 207829 None 60 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 7 1 6 3.5 O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1 10.1038/s41467-023-40064-9
119182 60427 None 59 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 2 3 8 -0.3 Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F 10.1038/s41467-023-40064-9
CHEMBL1750 60427 None 59 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 2 3 8 -0.3 Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F 10.1038/s41467-023-40064-9
2583 3776 None 69 Human Binding pAC50 = 4.7 4.7 - 1
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
592 3776 None 69 Human Binding pAC50 = 4.7 4.7 - 1
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
65999 3776 None 69 Human Binding pAC50 = 4.7 4.7 - 1
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
65999.0 3776 None 69 Human Binding pAC50 = 4.7 4.7 - 1
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
CHEMBL1017 3776 None 69 Human Binding pAC50 = 4.7 4.7 - 1
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
DB00966 3776 None 69 Human Binding pAC50 = 4.7 4.7 - 1
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
5735 25939 None 32 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 388 2 0 7 1.6 CN1CCN(C(=O)OC2c3nccnc3C(=O)N2c2ccc(Cl)cn2)CC1 10.1038/s41467-023-40064-9
CHEMBL135400 25939 None 32 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 388 2 0 7 1.6 CN1CCN(C(=O)OC2c3nccnc3C(=O)N2c2ccc(Cl)cn2)CC1 10.1038/s41467-023-40064-9
169870 14446 None 44 Human Binding pAC50 = 4.7 4.7 - 1
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 6 0 4 6.0 CCCCCC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL1200848 14446 None 44 Human Binding pAC50 = 4.7 4.7 - 1
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 6 0 4 6.0 CCCCCC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
8609 14449 None 44 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 229 2 2 4 2.2 Nc1ccc(C(=O)Oc2ccccc2)c(O)c1 10.1038/s41467-023-40064-9
CHEMBL1200868 14449 None 44 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 229 2 2 4 2.2 Nc1ccc(C(=O)Oc2ccccc2)c(O)c1 10.1038/s41467-023-40064-9
24812758 75829 None 54 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 444 5 4 6 3.0 Cc1ccc([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1Cc1ccc(-c2ccc(F)cc2)s1 10.1038/s41467-023-40064-9
CHEMBL2048484 75829 None 54 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 444 5 4 6 3.0 Cc1ccc([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1Cc1ccc(-c2ccc(F)cc2)s1 10.1038/s41467-023-40064-9
5090 15568 None 65 Human Binding pAC50 = 4.7 4.7 - 31
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 314 3 0 4 2.6 CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 10.1038/s41467-023-40064-9
CHEMBL122 15568 None 65 Human Binding pAC50 = 4.7 4.7 - 31
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 314 3 0 4 2.6 CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 10.1038/s41467-023-40064-9
2585 803 None 59 Human Binding pAC50 = 4.7 4.7 - 22
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
2585.0 803 None 59 Human Binding pAC50 = 4.7 4.7 - 22
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
522 803 None 59 Human Binding pAC50 = 4.7 4.7 - 22
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
551 803 None 59 Human Binding pAC50 = 4.7 4.7 - 22
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
CHEMBL723 803 None 59 Human Binding pAC50 = 4.7 4.7 - 22
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
DB01136 803 None 59 Human Binding pAC50 = 4.7 4.7 - 22
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
392622 56328 None 57 Human Binding pAC50 = 4.7 4.7 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
CHEMBL163 56328 None 57 Human Binding pAC50 = 4.7 4.7 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
216239 23803 None 71 Human Binding pAC50 = 5.7 5.7 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1038/s41467-023-40064-9
CHEMBL1200485 23803 None 71 Human Binding pAC50 = 5.7 5.7 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1038/s41467-023-40064-9
CHEMBL1336 23803 None 71 Human Binding pAC50 = 5.7 5.7 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1038/s41467-023-40064-9
2247 505 None 55 Human Binding pAC50 = 4.7 4.7 -162 41
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
249 505 None 55 Human Binding pAC50 = 4.7 4.7 -162 41
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
2603 505 None 55 Human Binding pAC50 = 4.7 4.7 -162 41
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
CHEMBL296419 505 None 55 Human Binding pAC50 = 4.7 4.7 -162 41
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
DB00637 505 None 55 Human Binding pAC50 = 4.7 4.7 -162 41
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
5568 199956 None 21 Human Binding pAC50 = 4.7 4.7 - 5
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 352 4 0 3 5.3 CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21 10.1038/s41467-023-40064-9
5568.0 199956 None 21 Human Binding pAC50 = 4.7 4.7 - 5
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 352 4 0 3 5.3 CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21 10.1038/s41467-023-40064-9
66069 199956 None 21 Human Binding pAC50 = 4.7 4.7 - 5
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 352 4 0 3 5.3 CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21 10.1038/s41467-023-40064-9
CHEMBL1201102 199956 None 21 Human Binding pAC50 = 4.7 4.7 - 5
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 352 4 0 3 5.3 CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21 10.1038/s41467-023-40064-9
CHEMBL570 199956 None 21 Human Binding pAC50 = 4.7 4.7 - 5
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 352 4 0 3 5.3 CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21 10.1038/s41467-023-40064-9
DB00508 199956 None 21 Human Binding pAC50 = 4.7 4.7 - 5
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 352 4 0 3 5.3 CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21 10.1038/s41467-023-40064-9
118422671 2757 None 41 Human Binding pAC50 = 4.7 4.7 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
1887 2757 None 41 Human Binding pAC50 = 4.7 4.7 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
189562 2757 None 41 Human Binding pAC50 = 4.7 4.7 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
189562.0 2757 None 41 Human Binding pAC50 = 4.7 4.7 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
71301 2757 None 41 Human Binding pAC50 = 4.7 4.7 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
71301.0 2757 None 41 Human Binding pAC50 = 4.7 4.7 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
7246 2757 None 41 Human Binding pAC50 = 4.7 4.7 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
9844194 2757 None 41 Human Binding pAC50 = 4.7 4.7 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
9844194.0 2757 None 41 Human Binding pAC50 = 4.7 4.7 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
CHEMBL2365658 2757 None 41 Human Binding pAC50 = 4.7 4.7 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
CHEMBL3526436 2757 None 41 Human Binding pAC50 = 4.7 4.7 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
CHEMBL434394 2757 None 41 Human Binding pAC50 = 4.7 4.7 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
DB04861 2757 None 41 Human Binding pAC50 = 4.7 4.7 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
4452 2762 None 13 Human Binding pAC50 = 4.7 4.7 - 18
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 6 2 4 3.8 COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl 10.1038/s41467-023-40064-9
983 2762 None 13 Human Binding pAC50 = 4.7 4.7 - 18
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 6 2 4 3.8 COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl 10.1038/s41467-023-40064-9
CHEMBL20734 2762 None 13 Human Binding pAC50 = 4.7 4.7 - 18
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 6 2 4 3.8 COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl 10.1038/s41467-023-40064-9
24821094 67115 None 58 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 5 1 7 4.2 C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 10.1038/s41467-023-40064-9
CHEMBL1873475 67115 None 58 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 5 1 7 4.2 C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 10.1038/s41467-023-40064-9
CHEMBL4743867 216518 None 10 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1 10.1038/s41467-023-40064-9
2540 4402 None 68 Human Binding pAC50 = 5.7 5.7 -1 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
CHEMBL1014 4402 None 68 Human Binding pAC50 = 5.7 5.7 -1 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
10311 57517 None 24 Human Binding pAC50 = 5.7 5.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 398 4 4 9 0.3 Nc1nc(N)nc(Nc2ccc([As]3SCC(CO)S3)cc2)n1 10.1038/s41467-023-40064-9
CHEMBL166 57517 None 24 Human Binding pAC50 = 5.7 5.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 398 4 4 9 0.3 Nc1nc(N)nc(Nc2ccc([As]3SCC(CO)S3)cc2)n1 10.1038/s41467-023-40064-9
31101 729 None 28 Human Binding pAC50 = 5.7 5.7 - 35
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
31101.0 729 None 28 Human Binding pAC50 = 5.7 5.7 - 35
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
35 729 None 28 Human Binding pAC50 = 5.7 5.7 - 35
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
403 729 None 28 Human Binding pAC50 = 5.7 5.7 - 35
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
CHEMBL493 729 None 28 Human Binding pAC50 = 5.7 5.7 - 35
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
DB01200 729 None 28 Human Binding pAC50 = 5.7 5.7 - 35
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
2028 2979 None 52 Human Binding pAC50 = 4.7 4.7 - 11
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 357 7 1 4 3.3 CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC 10.1038/s41467-023-40064-9
359 2979 None 52 Human Binding pAC50 = 4.7 4.7 - 11
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 357 7 1 4 3.3 CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC 10.1038/s41467-023-40064-9
4634 2979 None 52 Human Binding pAC50 = 4.7 4.7 - 11
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 357 7 1 4 3.3 CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC 10.1038/s41467-023-40064-9
4634.0 2979 None 52 Human Binding pAC50 = 4.7 4.7 - 11
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 357 7 1 4 3.3 CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC 10.1038/s41467-023-40064-9
CHEMBL1231 2979 None 52 Human Binding pAC50 = 4.7 4.7 - 11
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 357 7 1 4 3.3 CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC 10.1038/s41467-023-40064-9
DB01062 2979 None 52 Human Binding pAC50 = 4.7 4.7 - 11
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 357 7 1 4 3.3 CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC 10.1038/s41467-023-40064-9
10230 120815 None 34 Human Binding pAC50 = 6.7 6.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 190 0 4 4 -1.0 N/N=c1\[nH][nH]/c(=N\N)c2ccccc12 10.1038/s41467-023-40064-9
CHEMBL35505 120815 None 34 Human Binding pAC50 = 6.7 6.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 190 0 4 4 -1.0 N/N=c1\[nH][nH]/c(=N\N)c2ccccc12 10.1038/s41467-023-40064-9
6918178 14450 None 36 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 484 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL1200908 14450 None 36 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 484 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 10.1038/s41467-023-40064-9
2162 41527 None 58 Human Binding pAC50 = 4.7 4.7 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 408 8 2 7 2.3 CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl 10.1038/s41467-023-40064-9
CHEMBL1491 41527 None 58 Human Binding pAC50 = 4.7 4.7 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 408 8 2 7 2.3 CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl 10.1038/s41467-023-40064-9
42890 9427 None 34 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 497 3 5 10 1.0 CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O 10.1038/s41467-023-40064-9
CHEMBL1117 9427 None 34 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 497 3 5 10 1.0 CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O 10.1038/s41467-023-40064-9
2787 67572 None 57 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 468 10 2 4 6.2 CCC(C)(Oc1ccc(C2(c3ccc(OC(C)(CC)C(=O)O)cc3)CCCCC2)cc1)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL1897738 67572 None 57 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 468 10 2 4 6.2 CCC(C)(Oc1ccc(C2(c3ccc(OC(C)(CC)C(=O)O)cc3)CCCCC2)cc1)C(=O)O 10.1038/s41467-023-40064-9
4640 78295 None 23 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 379 6 1 4 3.9 COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC 10.1038/s41467-023-40064-9
CHEMBL2107011 78295 None 23 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 379 6 1 4 3.9 COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC 10.1038/s41467-023-40064-9
65769 154520 None 7 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 498 13 1 6 5.0 CCCO[C@H]1[C@@H]([C@@H](COCc2ccc(Cl)cc2)OCc2ccc(Cl)cc2)OC(OCC)[C@@H]1O 10.1038/s41467-023-40064-9
CHEMBL3989839 154520 None 7 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 498 13 1 6 5.0 CCCO[C@H]1[C@@H]([C@@H](COCc2ccc(Cl)cc2)OCc2ccc(Cl)cc2)OC(OCC)[C@@H]1O 10.1038/s41467-023-40064-9
1549120 198942 None 55 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 319 4 1 4 2.9 CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL56337 198942 None 55 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 319 4 1 4 2.9 CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 10.1038/s41467-023-40064-9
5351322 94844 None 30 Human Binding pAC50 = 5.7 5.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 398 4 4 8 1.8 C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12 10.1038/s41467-023-40064-9
CHEMBL25336 94844 None 30 Human Binding pAC50 = 5.7 5.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 398 4 4 8 1.8 C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12 10.1038/s41467-023-40064-9
6918456 14521 None 67 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 373 5 0 5 3.9 CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2 10.1038/s41467-023-40064-9
6918456.0 14521 None 67 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 373 5 0 5 3.9 CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2 10.1038/s41467-023-40064-9
CHEMBL1201772 14521 None 67 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 373 5 0 5 3.9 CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2 10.1038/s41467-023-40064-9
DB06209 14521 None 67 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 373 5 0 5 3.9 CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2 10.1038/s41467-023-40064-9
4494 190296 None 55 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 385 5 1 8 2.5 COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
CHEMBL517427 190296 None 55 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 385 5 1 8 2.5 COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
37907 35407 None 55 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 292 4 0 4 3.7 CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n1ccnc1 10.1038/s41467-023-40064-9
CHEMBL1437764 35407 None 55 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 292 4 0 4 3.7 CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n1ccnc1 10.1038/s41467-023-40064-9
3397 207946 None 70 Human Binding pAC50 = 4.7 4.7 - 2
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 276 3 1 3 3.2 CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1 10.1038/s41467-023-40064-9
CHEMBL806 207946 None 70 Human Binding pAC50 = 4.7 4.7 - 2
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 276 3 1 3 3.2 CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1 10.1038/s41467-023-40064-9
1499 2091 None 34 Human Binding pAC50 = 4.7 4.7 - 17
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1038/s41467-023-40064-9
3779 2091 None 34 Human Binding pAC50 = 4.7 4.7 - 17
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1038/s41467-023-40064-9
3779.0 2091 None 34 Human Binding pAC50 = 4.7 4.7 - 17
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1038/s41467-023-40064-9
536 2091 None 34 Human Binding pAC50 = 4.7 4.7 - 17
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1038/s41467-023-40064-9
CHEMBL434 2091 None 34 Human Binding pAC50 = 4.7 4.7 - 17
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1038/s41467-023-40064-9
DB01064 2091 None 34 Human Binding pAC50 = 4.7 4.7 - 17
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1038/s41467-023-40064-9
3784 57188 None 67 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 4 1 8 2.6 COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2nonc12 10.1038/s41467-023-40064-9
CHEMBL1648 57188 None 67 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 4 1 8 2.6 COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2nonc12 10.1038/s41467-023-40064-9
2726 919 None 48 Human Binding pAC50 = 4.7 4.7 - 72
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
2726.0 919 None 48 Human Binding pAC50 = 4.7 4.7 - 72
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
621 919 None 48 Human Binding pAC50 = 4.7 4.7 - 72
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
83 919 None 48 Human Binding pAC50 = 4.7 4.7 - 72
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
CHEMBL71 919 None 48 Human Binding pAC50 = 4.7 4.7 - 72
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
DB00477 919 None 48 Human Binding pAC50 = 4.7 4.7 - 72
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
7547 5506 None 61 Human Binding pAC50 = 5.7 5.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 314 2 2 1 5.3 O=C(Nc1ccc(Cl)cc1)Nc1ccc(Cl)c(Cl)c1 10.1038/s41467-023-40064-9
CHEMBL1076347 5506 None 61 Human Binding pAC50 = 5.7 5.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 314 2 2 1 5.3 O=C(Nc1ccc(Cl)cc1)Nc1ccc(Cl)c(Cl)c1 10.1038/s41467-023-40064-9
11511120 78425 None 58 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 469 7 2 6 5.2 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN1CCCCC1 10.1038/s41467-023-40064-9
CHEMBL2110732 78425 None 58 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 469 7 2 6 5.2 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN1CCCCC1 10.1038/s41467-023-40064-9
53276 95087 None 38 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 304 5 3 5 3.0 CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)nc1N 10.1038/s41467-023-40064-9
CHEMBL255044 95087 None 38 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 304 5 3 5 3.0 CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)nc1N 10.1038/s41467-023-40064-9
4413 98126 None 43 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 347 4 5 4 2.6 N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1 10.1038/s41467-023-40064-9
CHEMBL273264 98126 None 43 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 347 4 5 4 2.6 N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1 10.1038/s41467-023-40064-9
9324 9240 None 40 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 404 2 0 4 4.8 CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL110691 9240 None 40 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 404 2 0 4 4.8 CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
5284616 161721 None 39 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 914 6 3 13 6.2 CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C 10.1038/s41467-023-40064-9
CHEMBL413 161721 None 39 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 914 6 3 13 6.2 CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C 10.1038/s41467-023-40064-9
2398 954 None 43 Human Binding pAC50 = 4.7 4.7 - 28
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
2801 954 None 43 Human Binding pAC50 = 4.7 4.7 - 28
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
2801.0 954 None 43 Human Binding pAC50 = 4.7 4.7 - 28
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
701 954 None 43 Human Binding pAC50 = 4.7 4.7 - 28
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
CHEMBL415 954 None 43 Human Binding pAC50 = 4.7 4.7 - 28
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
DB01242 954 None 43 Human Binding pAC50 = 4.7 4.7 - 28
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
5625 202124 None 46 Human Binding pAC50 = 4.7 4.7 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 456 6 3 6 2.7 CC(C)Nc1cccnc1N1CCN(C(=O)c2cc3cc(NS(C)(=O)=O)ccc3[nH]2)CC1 10.1038/s41467-023-40064-9
CHEMBL593 202124 None 46 Human Binding pAC50 = 4.7 4.7 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 456 6 3 6 2.7 CC(C)Nc1cccnc1N1CCN(C(=O)c2cc3cc(NS(C)(=O)=O)ccc3[nH]2)CC1 10.1038/s41467-023-40064-9
3062316 33583 None 70 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 487 7 3 9 3.3 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 10.1038/s41467-023-40064-9
CHEMBL1421 33583 None 70 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 487 7 3 9 3.3 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 10.1038/s41467-023-40064-9
CHEMBL5416410 33583 None 70 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 487 7 3 9 3.3 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 10.1038/s41467-023-40064-9
2327 8844 None 30 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 257 5 7 7 -1.8 NC(CO)C(=O)NNCc1ccc(O)c(O)c1O 10.1038/s41467-023-40064-9
CHEMBL1096979 8844 None 30 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 257 5 7 7 -1.8 NC(CO)C(=O)NNCc1ccc(O)c(O)c1O 10.1038/s41467-023-40064-9
CHEMBL1255778 8844 None 30 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 257 5 7 7 -1.8 NC(CO)C(=O)NNCc1ccc(O)c(O)c1O 10.1038/s41467-023-40064-9
3778 99536 None 55 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 230 2 0 3 2.6 Cc1c(C(C)C)c(=O)n(-c2ccccc2)n1C 10.1038/s41467-023-40064-9
CHEMBL28318 99536 None 55 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 230 2 0 3 2.6 Cc1c(C(C)C)c(=O)n(-c2ccccc2)n1C 10.1038/s41467-023-40064-9
6917906 67795 None 17 Human Binding pAC50 = 5.7 5.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 887 35 10 12 1.7 CCCCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)CC[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O)C(N)=O)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL1908331 67795 None 17 Human Binding pAC50 = 5.7 5.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 887 35 10 12 1.7 CCCCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)CC[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O)C(N)=O)C(=O)O 10.1038/s41467-023-40064-9
11976 920 None 44 Human Binding pAC50 = 4.7 4.7 - 23
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
667467 920 None 44 Human Binding pAC50 = 4.7 4.7 - 23
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
667467.0 920 None 44 Human Binding pAC50 = 4.7 4.7 - 23
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
CHEMBL908 920 None 44 Human Binding pAC50 = 4.7 4.7 - 23
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
DB01239 920 None 44 Human Binding pAC50 = 4.7 4.7 - 23
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
5281087 16619 None 24 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 216 2 1 3 2.1 CN1CCCN=C1/C=C/c1cccc(O)c1 10.1038/s41467-023-40064-9
CHEMBL1240977 16619 None 24 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 216 2 1 3 2.1 CN1CCCN=C1/C=C/c1cccc(O)c1 10.1038/s41467-023-40064-9
65981 18461 None 59 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 452 10 2 4 5.2 CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(=O)O 10.1038/s41467-023-40064-9
CHEMBL1272 18461 None 59 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 452 10 2 4 5.2 CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(=O)O 10.1038/s41467-023-40064-9
27812 67012 None 31 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 308 1 1 2 3.7 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3C=C[C@@]21CC 10.1038/s41467-023-40064-9
CHEMBL1868702 67012 None 31 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 308 1 1 2 3.7 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3C=C[C@@]21CC 10.1038/s41467-023-40064-9
5330286 67592 None 57 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 5 2 9 3.0 CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O 10.1038/s41467-023-40064-9
CHEMBL189963 67592 None 57 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 5 2 9 3.0 CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O 10.1038/s41467-023-40064-9
5029 15552 None 54 Human Binding pAC50 = 5.7 5.7 -19 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 359 8 1 5 3.0 COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C 10.1038/s41467-023-40064-9
CHEMBL1219 15552 None 54 Human Binding pAC50 = 5.7 5.7 -19 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 359 8 1 5 3.0 COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C 10.1038/s41467-023-40064-9
65948 18563 None 62 Human Binding pAC50 = 5.7 5.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 582 9 2 9 4.7 CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 10.1038/s41467-023-40064-9
CHEMBL1275868 18563 None 62 Human Binding pAC50 = 5.7 5.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 582 9 2 9 4.7 CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 10.1038/s41467-023-40064-9
9064 105275 None 56 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 290 1 5 6 1.5 Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2 10.1038/s41467-023-40064-9
CHEMBL311498 105275 None 56 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 290 1 5 6 1.5 Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2 10.1038/s41467-023-40064-9
6314185 191515 None 17 Human Binding pAC50 = 5.7 5.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 353 7 1 2 5.2 CCNC(=O)/C=C(C)/C=C/C=C(C)/C=C/c1c(C)cc(OC)c(C)c1C 10.1038/s41467-023-40064-9
CHEMBL519260 191515 None 17 Human Binding pAC50 = 5.7 5.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 353 7 1 2 5.2 CCNC(=O)/C=C(C)/C=C/C=C(C)/C=C/c1c(C)cc(OC)c(C)c1C 10.1038/s41467-023-40064-9
34040 28093 None 52 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 483 4 0 6 3.9 CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13 10.1038/s41467-023-40064-9
34040.0 28093 None 52 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 483 4 0 6 3.9 CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13 10.1038/s41467-023-40064-9
CHEMBL1372950 28093 None 52 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 483 4 0 6 3.9 CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13 10.1038/s41467-023-40064-9
DB00699 28093 None 52 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 483 4 0 6 3.9 CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13 10.1038/s41467-023-40064-9
43815 187026 None 38 Human Binding pAC50 = 4.7 4.7 - 24
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1038/s41467-023-40064-9
CHEMBL1708 187026 None 38 Human Binding pAC50 = 4.7 4.7 - 24
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1038/s41467-023-40064-9
CHEMBL490 187026 None 38 Human Binding pAC50 = 4.7 4.7 - 24
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1038/s41467-023-40064-9
1960 2857 None 46 Human Binding pAC50 = 4.6 4.6 - 27
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
439260 2857 None 46 Human Binding pAC50 = 4.6 4.6 - 27
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
439260.0 2857 None 46 Human Binding pAC50 = 4.6 4.6 - 27
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
505 2857 None 46 Human Binding pAC50 = 4.6 4.6 - 27
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
CHEMBL1437 2857 None 46 Human Binding pAC50 = 4.6 4.6 - 27
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
DB00368 2857 None 46 Human Binding pAC50 = 4.6 4.6 - 27
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
36811 1454 None 27 Human Binding pAC50 = 4.6 4.6 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
36811.0 1454 None 27 Human Binding pAC50 = 4.6 4.6 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
535 1454 None 27 Human Binding pAC50 = 4.6 4.6 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
937 1454 None 27 Human Binding pAC50 = 4.6 4.6 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
CHEMBL926 1454 None 27 Human Binding pAC50 = 4.6 4.6 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
DB00841 1454 None 27 Human Binding pAC50 = 4.6 4.6 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
16220172 73068 None 63 Human Binding pAC50 = 5.6 5.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 2 3 3 5.1 CC(C)(C)c1cc(C(C)(C)C)c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O 10.1038/s41467-023-40064-9
CHEMBL2010601 73068 None 63 Human Binding pAC50 = 5.6 5.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 2 3 3 5.1 CC(C)(C)c1cc(C(C)(C)C)c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O 10.1038/s41467-023-40064-9
49846579 106225 None 66 Human Binding pAC50 = 5.6 5.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 867 13 3 11 8.7 CC1(C)CCC(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(NCC5CCOCC5)c([N+](=O)[O-])c4)c(Oc4cnc5[nH]ccc5c4)c3)CC2)=C(c2ccc(Cl)cc2)C1 10.1038/s41467-023-40064-9
CHEMBL3137309 106225 None 66 Human Binding pAC50 = 5.6 5.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 867 13 3 11 8.7 CC1(C)CCC(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(NCC5CCOCC5)c([N+](=O)[O-])c4)c(Oc4cnc5[nH]ccc5c4)c3)CC2)=C(c2ccc(Cl)cc2)C1 10.1038/s41467-023-40064-9
3081361 93987 None 66 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 474 5 1 5 4.4 COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 10.1038/s41467-023-40064-9
CHEMBL24828 93987 None 66 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 474 5 1 5 4.4 COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 10.1038/s41467-023-40064-9
31508 97271 None 31 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 278 2 0 3 4.0 Cc1ccc2c(-c3ccccc3)nc(=O)n(C(C)C)c2c1 10.1038/s41467-023-40064-9
CHEMBL268501 97271 None 31 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 278 2 0 3 4.0 Cc1ccc2c(-c3ccccc3)nc(=O)n(C(C)C)c2c1 10.1038/s41467-023-40064-9
447715 199383 None 50 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1038/s41467-023-40064-9
CHEMBL566315 199383 None 50 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1038/s41467-023-40064-9
2153 3800 None 72 Human Binding pAC50 = 4.6 4.6 -35 14
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 180 0 1 5 -1.0 Cn1c(=O)n(C)c2c(c1=O)[nH]cn2 10.1038/s41467-023-40064-9
2153.0 3800 None 72 Human Binding pAC50 = 4.6 4.6 -35 14
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 180 0 1 5 -1.0 Cn1c(=O)n(C)c2c(c1=O)[nH]cn2 10.1038/s41467-023-40064-9
2620 3800 None 72 Human Binding pAC50 = 4.6 4.6 -35 14
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 180 0 1 5 -1.0 Cn1c(=O)n(C)c2c(c1=O)[nH]cn2 10.1038/s41467-023-40064-9
413 3800 None 72 Human Binding pAC50 = 4.6 4.6 -35 14
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 180 0 1 5 -1.0 Cn1c(=O)n(C)c2c(c1=O)[nH]cn2 10.1038/s41467-023-40064-9
CHEMBL190 3800 None 72 Human Binding pAC50 = 4.6 4.6 -35 14
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 180 0 1 5 -1.0 Cn1c(=O)n(C)c2c(c1=O)[nH]cn2 10.1038/s41467-023-40064-9
DB00277 3800 None 72 Human Binding pAC50 = 4.6 4.6 -35 14
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 180 0 1 5 -1.0 Cn1c(=O)n(C)c2c(c1=O)[nH]cn2 10.1038/s41467-023-40064-9
4497 34413 None 64 Human Binding pAC50 = 4.6 4.6 -2 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 418 8 1 8 3.0 COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
CHEMBL1428 34413 None 64 Human Binding pAC50 = 4.6 4.6 -2 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 418 8 1 8 3.0 COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
444036 39550 None 45 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 500 4 1 6 4.4 CCC(=O)O[C@]1(C(=O)SCF)[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL1473 39550 None 45 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 500 4 1 6 4.4 CCC(=O)O[C@]1(C(=O)SCF)[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 10.1038/s41467-023-40064-9
68617 207985 None 33 Human Binding pAC50 = 4.6 4.6 - 25
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL1709 207985 None 33 Human Binding pAC50 = 4.6 4.6 - 25
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL809 207985 None 33 Human Binding pAC50 = 4.6 4.6 - 25
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 10.1038/s41467-023-40064-9
12431 602 None 70 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 216 1 0 4 2.5 COC1=C2C=CC(=O)OC2=CC3=C1C=CO3 10.1038/s41467-023-40064-9
2355 602 None 70 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 216 1 0 4 2.5 COC1=C2C=CC(=O)OC2=CC3=C1C=CO3 10.1038/s41467-023-40064-9
CHEMBL24171 602 None 70 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 216 1 0 4 2.5 COC1=C2C=CC(=O)OC2=CC3=C1C=CO3 10.1038/s41467-023-40064-9
DB12216 602 None 70 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 216 1 0 4 2.5 COC1=C2C=CC(=O)OC2=CC3=C1C=CO3 10.1038/s41467-023-40064-9
1548955 88615 None 14 Human Binding pAC50 = 5.6 5.6 -1 18
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 10.1038/s41467-023-40064-9
2800 88615 None 14 Human Binding pAC50 = 5.6 5.6 -1 18
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL2355051 88615 None 14 Human Binding pAC50 = 5.6 5.6 -1 18
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 10.1038/s41467-023-40064-9
119607 208661 None 64 Human Binding pAC50 = 4.6 4.6 - 28
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 314 3 1 4 3.0 Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 10.1038/s41467-023-40064-9
CHEMBL865 208661 None 64 Human Binding pAC50 = 4.6 4.6 - 28
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 314 3 1 4 3.0 Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 10.1038/s41467-023-40064-9
4882 2099 None 54 Human Binding pAC50 = 4.6 4.6 -107 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 384 6 0 8 2.1 COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC 10.1038/s41467-023-40064-9
5311037 2099 None 54 Human Binding pAC50 = 4.6 4.6 -107 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 384 6 0 8 2.1 COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC 10.1038/s41467-023-40064-9
5311037.0 2099 None 54 Human Binding pAC50 = 4.6 4.6 -107 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 384 6 0 8 2.1 COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC 10.1038/s41467-023-40064-9
5608 2099 None 54 Human Binding pAC50 = 4.6 4.6 -107 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 384 6 0 8 2.1 COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC 10.1038/s41467-023-40064-9
CHEMBL431770 2099 None 54 Human Binding pAC50 = 4.6 4.6 -107 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 384 6 0 8 2.1 COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC 10.1038/s41467-023-40064-9
DB11757 2099 None 54 Human Binding pAC50 = 4.6 4.6 -107 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 384 6 0 8 2.1 COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC 10.1038/s41467-023-40064-9
2407 3372 None 50 Human Binding pAC50 = 4.6 4.6 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 10.1038/s41467-023-40064-9
59227 3372 None 50 Human Binding pAC50 = 4.6 4.6 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 10.1038/s41467-023-40064-9
59227.0 3372 None 50 Human Binding pAC50 = 4.6 4.6 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 10.1038/s41467-023-40064-9
941 3372 None 50 Human Binding pAC50 = 4.6 4.6 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 10.1038/s41467-023-40064-9
CHEMBL1303 3372 None 50 Human Binding pAC50 = 4.6 4.6 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 10.1038/s41467-023-40064-9
DB05271 3372 None 50 Human Binding pAC50 = 4.6 4.6 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 10.1038/s41467-023-40064-9
21800 14419 None 30 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 6 1 7 3.8 CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL1200384 14419 None 30 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 6 1 7 3.8 CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 10.1038/s41467-023-40064-9
51039 206223 None 48 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 367 4 3 5 0.6 N[C@@H](C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(Cl)CS[C@H]12)c1ccccc1 10.1038/s41467-023-40064-9
7048572 206223 None 48 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 367 4 3 5 0.6 N[C@@H](C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(Cl)CS[C@H]12)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL680 206223 None 48 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 367 4 3 5 0.6 N[C@@H](C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(Cl)CS[C@H]12)c1ccccc1 10.1038/s41467-023-40064-9
10077130 4007 None 47 Human Binding pAC50 = 5.6 5.6 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 492 5 1 5 5.6 CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]1[C@H]([C@H]2/C=C/c2ccc(cn2)c2cccc(c2)F)[C@H](OC1=O)C 10.1038/s41467-023-40064-9
10077130.0 4007 None 47 Human Binding pAC50 = 5.6 5.6 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 492 5 1 5 5.6 CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]1[C@H]([C@H]2/C=C/c2ccc(cn2)c2cccc(c2)F)[C@H](OC1=O)C 10.1038/s41467-023-40064-9
4047 4007 None 47 Human Binding pAC50 = 5.6 5.6 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 492 5 1 5 5.6 CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]1[C@H]([C@H]2/C=C/c2ccc(cn2)c2cccc(c2)F)[C@H](OC1=O)C 10.1038/s41467-023-40064-9
4870 4007 None 47 Human Binding pAC50 = 5.6 5.6 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 492 5 1 5 5.6 CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]1[C@H]([C@H]2/C=C/c2ccc(cn2)c2cccc(c2)F)[C@H](OC1=O)C 10.1038/s41467-023-40064-9
CHEMBL493982 4007 None 47 Human Binding pAC50 = 5.6 5.6 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 492 5 1 5 5.6 CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]1[C@H]([C@H]2/C=C/c2ccc(cn2)c2cccc(c2)F)[C@H](OC1=O)C 10.1038/s41467-023-40064-9
DB09030 4007 None 47 Human Binding pAC50 = 5.6 5.6 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 492 5 1 5 5.6 CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]1[C@H]([C@H]2/C=C/c2ccc(cn2)c2cccc(c2)F)[C@H](OC1=O)C 10.1038/s41467-023-40064-9
92727 207010 None 50 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 628 15 4 5 4.3 Cc1cccc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N1CCCNC1=O 10.1038/s41467-023-40064-9
CHEMBL729 207010 None 50 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 628 15 4 5 4.3 Cc1cccc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N1CCCNC1=O 10.1038/s41467-023-40064-9
2351 3286 None 44 Human Binding pAC50 = 4.6 4.6 - 21
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 10.1038/s41467-023-40064-9
2820 3286 None 44 Human Binding pAC50 = 4.6 4.6 - 21
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 10.1038/s41467-023-40064-9
5035 3286 None 44 Human Binding pAC50 = 4.6 4.6 - 21
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 10.1038/s41467-023-40064-9
CHEMBL81 3286 None 44 Human Binding pAC50 = 4.6 4.6 - 21
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 10.1038/s41467-023-40064-9
DB00481 3286 None 44 Human Binding pAC50 = 4.6 4.6 - 21
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 10.1038/s41467-023-40064-9
2898 32659 None 43 Human Binding pAC50 = 5.6 5.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 364 4 0 4 5.3 CC(=O)Oc1ccc(C(=C2CCCCC2)c2ccc(OC(C)=O)cc2)cc1 10.1038/s41467-023-40064-9
CHEMBL141305 32659 None 43 Human Binding pAC50 = 5.6 5.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 364 4 0 4 5.3 CC(=O)Oc1ccc(C(=C2CCCCC2)c2ccc(OC(C)=O)cc2)cc1 10.1038/s41467-023-40064-9
3108 209745 None 64 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 12 4 12 -0.0 OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1 10.1038/s41467-023-40064-9
CHEMBL932 209745 None 64 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 12 4 12 -0.0 OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1 10.1038/s41467-023-40064-9
103 4153 None 44 Human Binding pAC50 = 4.6 4.6 - 53
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
2875 4153 None 44 Human Binding pAC50 = 4.6 4.6 - 53
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
5736 4153 None 44 Human Binding pAC50 = 4.6 4.6 - 53
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
CHEMBL285802 4153 None 44 Human Binding pAC50 = 4.6 4.6 - 53
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
DB09225 4153 None 44 Human Binding pAC50 = 4.6 4.6 - 53
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
54697325 58996 None 30 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 556 6 6 10 1.3 CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O 10.1038/s41467-023-40064-9
CHEMBL1689772 58996 None 30 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 556 6 6 10 1.3 CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O 10.1038/s41467-023-40064-9
176870 197941 None 62 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 393 10 1 7 3.4 C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 10.1038/s41467-023-40064-9
CHEMBL553 197941 None 62 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 393 10 1 7 3.4 C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 10.1038/s41467-023-40064-9
4495 198991 None 63 Human Binding pAC50 = 4.6 4.6 - 30
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 308 5 1 5 2.8 CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL56367 198991 None 63 Human Binding pAC50 = 4.6 4.6 - 30
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 308 5 1 5 2.8 CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 10.1038/s41467-023-40064-9
4066 207084 None 54 Human Binding pAC50 = 4.6 4.6 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 322 2 0 3 4.6 c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2 10.1038/s41467-023-40064-9
4066.0 207084 None 54 Human Binding pAC50 = 4.6 4.6 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 322 2 0 3 4.6 c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2 10.1038/s41467-023-40064-9
CHEMBL73451 207084 None 54 Human Binding pAC50 = 4.6 4.6 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 322 2 0 3 4.6 c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2 10.1038/s41467-023-40064-9
DB01071 207084 None 54 Human Binding pAC50 = 4.6 4.6 - 7
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 322 2 0 3 4.6 c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2 10.1038/s41467-023-40064-9
123631 209859 None 72 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 446 8 1 7 4.3 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 10.1038/s41467-023-40064-9
CHEMBL939 209859 None 72 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 446 8 1 7 4.3 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 10.1038/s41467-023-40064-9
11167602 70484 None 73 Human Binding pAC50 = 5.6 5.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 482 5 3 4 5.7 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1 10.1038/s41467-023-40064-9
CHEMBL1946170 70484 None 73 Human Binding pAC50 = 5.6 5.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 482 5 3 4 5.7 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1 10.1038/s41467-023-40064-9
448537 160344 None 54 Human Binding pAC50 = 5.6 5.6 -16 25
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 10.1038/s41467-023-40064-9
CHEMBL411 160344 None 54 Human Binding pAC50 = 5.6 5.6 -16 25
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 10.1038/s41467-023-40064-9
3174 1570 None 51 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1038/s41467-023-40064-9
3362 1570 None 51 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1038/s41467-023-40064-9
446284 1570 None 51 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1038/s41467-023-40064-9
CHEMBL460026 1570 None 51 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1038/s41467-023-40064-9
DB00159 1570 None 51 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1038/s41467-023-40064-9
71743 78296 None 47 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 353 3 0 4 3.6 O=C(Oc1ccc2c(c1)CCCN2C(=O)C(Cl)Cl)c1ccco1 10.1038/s41467-023-40064-9
CHEMBL2107014 78296 None 47 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 353 3 0 4 3.6 O=C(Oc1ccc2c(c1)CCCN2C(=O)C(Cl)Cl)c1ccco1 10.1038/s41467-023-40064-9
176 398 None 47 Human Binding pAC50 = 4.6 4.6 -5 31
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
2157 398 None 47 Human Binding pAC50 = 4.6 4.6 -5 31
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
2157.0 398 None 47 Human Binding pAC50 = 4.6 4.6 -5 31
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
2566 398 None 47 Human Binding pAC50 = 4.6 4.6 -5 31
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
CHEMBL633 398 None 47 Human Binding pAC50 = 4.6 4.6 -5 31
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
DB01118 398 None 47 Human Binding pAC50 = 4.6 4.6 -5 31
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
4822 45046 None 35 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 293 0 0 2 4.7 CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1 10.1038/s41467-023-40064-9
CHEMBL152408 45046 None 35 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 293 0 0 2 4.7 CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1 10.1038/s41467-023-40064-9
31640 210407 None 7 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 352 2 0 2 4.1 O=C1CN=C(c2ccccc2)c2cc(Cl)ccc2N1CC(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL970 210407 None 7 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 352 2 0 2 4.1 O=C1CN=C(c2ccccc2)c2cc(Cl)ccc2N1CC(F)(F)F 10.1038/s41467-023-40064-9
3151 1462 None 65 Human Binding pAC50 = 4.6 4.6 - 26
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
3151.0 1462 None 65 Human Binding pAC50 = 4.6 4.6 - 26
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
945 1462 None 65 Human Binding pAC50 = 4.6 4.6 - 26
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
965 1462 None 65 Human Binding pAC50 = 4.6 4.6 - 26
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL219916 1462 None 65 Human Binding pAC50 = 4.6 4.6 - 26
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB01184 1462 None 65 Human Binding pAC50 = 4.6 4.6 - 26
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
10096344 89628 None 56 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 472 4 1 10 1.1 CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C 10.1038/s41467-023-40064-9
CHEMBL237500 89628 None 56 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 472 4 1 10 1.1 CC#CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C 10.1038/s41467-023-40064-9
1193 1656 None 64 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 3 2 2 4.1 OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
2447 1656 None 64 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 3 2 2 4.1 OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
3371 1656 None 64 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 3 2 2 4.1 OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL23588 1656 None 64 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 3 2 2 4.1 OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
DB02266 1656 None 64 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 281 3 2 2 4.1 OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
1712095 197848 None 22 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 397 9 1 5 4.9 CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC 10.1038/s41467-023-40064-9
CHEMBL551978 197848 None 22 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 397 9 1 5 4.9 CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC 10.1038/s41467-023-40064-9
5284616 161721 None 39 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 914 6 3 13 6.2 CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C 10.1038/s41467-023-40064-9
CHEMBL413 161721 None 39 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 914 6 3 13 6.2 CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C 10.1038/s41467-023-40064-9
55245 18587 None 43 Human Binding pAC50 = 5.6 5.6 - 3
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 429 2 1 3 5.4 CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C)cc3)C[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL1276308 18587 None 43 Human Binding pAC50 = 5.6 5.6 - 3
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 429 2 1 3 5.4 CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C)cc3)C[C@@]21C 10.1038/s41467-023-40064-9
30323 62505 None 35 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 527 4 5 11 1.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
CHEMBL1563 62505 None 35 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 527 4 5 11 1.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
CHEMBL178 62505 None 35 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 527 4 5 11 1.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
5770 207516 None 57 Human Binding pAC50 = 4.6 4.6 - 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 608 8 1 10 4.2 COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC 10.1038/s41467-023-40064-9
CHEMBL772 207516 None 57 Human Binding pAC50 = 4.6 4.6 - 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 608 8 1 10 4.2 COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC 10.1038/s41467-023-40064-9
3336 95054 None 22 Human Binding pAC50 = 4.6 4.6 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 315 7 1 1 5.6 CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1405922 95054 None 22 Human Binding pAC50 = 4.6 4.6 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 315 7 1 1 5.6 CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL254832 95054 None 22 Human Binding pAC50 = 4.6 4.6 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 315 7 1 1 5.6 CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
1440 2027 None 69 Human Binding pAC50 = 4.6 4.6 - 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 4 1 4 3.9 COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
1909 2027 None 69 Human Binding pAC50 = 4.6 4.6 - 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 4 1 4 3.9 COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
3715 2027 None 69 Human Binding pAC50 = 4.6 4.6 - 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 4 1 4 3.9 COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
CHEMBL6 2027 None 69 Human Binding pAC50 = 4.6 4.6 - 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 4 1 4 3.9 COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
DB00328 2027 None 69 Human Binding pAC50 = 4.6 4.6 - 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 4 1 4 3.9 COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
54686904 137957 None 54 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 585 6 7 11 0.5 CN(C)c1cc(NC(=O)CNC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O 10.1038/s41467-023-40064-9
CHEMBL376140 137957 None 54 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 585 6 7 11 0.5 CN(C)c1cc(NC(=O)CNC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O 10.1038/s41467-023-40064-9
38103 53808 None 48 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 349 4 3 5 0.3 CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)C3=CCC=CC3)[C@H]2SC1 10.1038/s41467-023-40064-9
40467109 53808 None 48 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 349 4 3 5 0.3 CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)C3=CCC=CC3)[C@H]2SC1 10.1038/s41467-023-40064-9
CHEMBL1604 53808 None 48 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 349 4 3 5 0.3 CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)C3=CCC=CC3)[C@H]2SC1 10.1038/s41467-023-40064-9
65709 59901 None 35 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 365 8 0 5 3.3 CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21 10.1038/s41467-023-40064-9
CHEMBL1729803 59901 None 35 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 365 8 0 5 3.3 CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21 10.1038/s41467-023-40064-9
1548943 101022 None 63 Human Binding pAC50 = 4.6 4.6 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 305 9 2 3 3.8 COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O 10.1038/s41467-023-40064-9
CHEMBL294199 101022 None 63 Human Binding pAC50 = 4.6 4.6 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 305 9 2 3 3.8 COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O 10.1038/s41467-023-40064-9
135398735 137055 None 20 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
136262914 137055 None 20 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL374478 137055 None 20 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
25025298 78180 None 37 Human Binding pAC50 = 5.6 5.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 546 8 3 8 4.5 Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1 10.1038/s41467-023-40064-9
CHEMBL2103855 78180 None 37 Human Binding pAC50 = 5.6 5.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 546 8 3 8 4.5 Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1 10.1038/s41467-023-40064-9
445643 97442 None 46 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 803 7 3 12 4.6 C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC 10.1038/s41467-023-40064-9
CHEMBL269732 97442 None 46 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 803 7 3 12 4.6 C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC 10.1038/s41467-023-40064-9
1613 2348 None 42 Human Binding pAC50 = 4.6 4.6 - 44
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
205 2348 None 42 Human Binding pAC50 = 4.6 4.6 - 44
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
3964 2348 None 42 Human Binding pAC50 = 4.6 4.6 - 44
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
3964.0 2348 None 42 Human Binding pAC50 = 4.6 4.6 - 44
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
CHEMBL831 2348 None 42 Human Binding pAC50 = 4.6 4.6 - 44
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
DB00408 2348 None 42 Human Binding pAC50 = 4.6 4.6 - 44
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
54585 14508 None 49 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 7 4 6 2.7 O=C(O)CCNC(=O)c1ccc(/N=N/c2ccc(O)c(C(=O)O)c2)cc1 10.1038/s41467-023-40064-9
CHEMBL1201346 14508 None 49 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 7 4 6 2.7 O=C(O)CCNC(=O)c1ccc(/N=N/c2ccc(O)c(C(=O)O)c2)cc1 10.1038/s41467-023-40064-9
2442 94846 None 40 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 374 3 1 2 4.6 CN(Cc1cc(Br)cc(Br)c1N)C1CCCCC1 10.1038/s41467-023-40064-9
CHEMBL253376 94846 None 40 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 374 3 1 2 4.6 CN(Cc1cc(Br)cc(Br)c1N)C1CCCCC1 10.1038/s41467-023-40064-9
11289 14443 None 47 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 380 6 0 3 5.9 COc1ccc(C(Cl)=C(c2ccc(OC)cc2)c2ccc(OC)cc2)cc1 10.1038/s41467-023-40064-9
CHEMBL1200761 14443 None 47 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 380 6 0 3 5.9 COc1ccc(C(Cl)=C(c2ccc(OC)cc2)c2ccc(OC)cc2)cc1 10.1038/s41467-023-40064-9
2318 154946 None 18 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 351 7 1 3 4.1 CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL400599 154946 None 18 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 351 7 1 3 4.1 CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1 10.1038/s41467-023-40064-9
64143 201320 None 42 Human Binding pAC50 = 5.6 5.6 -1 8
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 567 9 4 6 4.7 Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C 10.1038/s41467-023-40064-9
CHEMBL584 201320 None 42 Human Binding pAC50 = 5.6 5.6 -1 8
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 567 9 4 6 4.7 Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C 10.1038/s41467-023-40064-9
9270 14435 None 44 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 384 2 0 4 4.4 C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C[C@@H](OC(C)=O)CC[C@@H]4[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL1200624 14435 None 44 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 384 2 0 4 4.4 C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C[C@@H](OC(C)=O)CC[C@@H]4[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
53232 188732 None 57 Human Binding pAC50 = 4.5 4.5 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
CHEMBL503 188732 None 57 Human Binding pAC50 = 4.5 4.5 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
4594 42886 None 68 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 345 5 1 5 2.9 COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1 10.1038/s41467-023-40064-9
CHEMBL1503 42886 None 68 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 345 5 1 5 2.9 COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1 10.1038/s41467-023-40064-9
2406 100458 None 56 Human Binding pAC50 = 5.5 5.5 -10 12
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O 10.1038/s41467-023-40064-9
CHEMBL290106 100458 None 56 Human Binding pAC50 = 5.5 5.5 -10 12
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O 10.1038/s41467-023-40064-9
6047 4324 None 68 Human Binding pAC50 = 4.5 4.5 - 3
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 197 3 4 4 0.1 N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O 10.1038/s41467-023-40064-9
6047.0 4324 None 68 Human Binding pAC50 = 4.5 4.5 - 3
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 197 3 4 4 0.1 N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O 10.1038/s41467-023-40064-9
6971033 4324 None 68 Human Binding pAC50 = 4.5 4.5 - 3
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 197 3 4 4 0.1 N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL1009 4324 None 68 Human Binding pAC50 = 4.5 4.5 - 3
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 197 3 4 4 0.1 N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O 10.1038/s41467-023-40064-9
DB01235 4324 None 68 Human Binding pAC50 = 4.5 4.5 - 3
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 197 3 4 4 0.1 N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O 10.1038/s41467-023-40064-9
6602341 112871 None 11 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 521 6 4 8 1.4 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)c3cnc4cccnc4c3O)c3ccccc3)C(=O)N2[C@H]1C(=O)O 10.1038/s41467-023-40064-9
CHEMBL3306902 112871 None 11 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 521 6 4 8 1.4 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)c3cnc4cccnc4c3O)c3ccccc3)C(=O)N2[C@H]1C(=O)O 10.1038/s41467-023-40064-9
24821094 67115 None 58 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 440 5 1 7 4.2 C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 10.1038/s41467-023-40064-9
CHEMBL1873475 67115 None 58 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 440 5 1 7 4.2 C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 10.1038/s41467-023-40064-9
10184665 3991 None 42 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
10184665.0 3991 None 42 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
4799 3991 None 42 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
7353 3991 None 42 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
CHEMBL1198857 3991 None 42 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
DB09082 3991 None 42 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
5070 207198 None 77 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 234 1 1 4 2.8 Nc1nc2ccc(OC(F)(F)F)cc2s1 10.1038/s41467-023-40064-9
CHEMBL744 207198 None 77 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 234 1 1 4 2.8 Nc1nc2ccc(OC(F)(F)F)cc2s1 10.1038/s41467-023-40064-9
5994 4643 None 51 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 314 1 0 2 4.7 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1038/s41467-023-40064-9
CHEMBL103 4643 None 51 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 314 1 0 2 4.7 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1038/s41467-023-40064-9
4037 189124 None 43 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 295 3 2 2 4.7 Cc1ccc(Cl)c(Nc2ccccc2C(=O)O)c1Cl 10.1038/s41467-023-40064-9
CHEMBL509 189124 None 43 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 295 3 2 2 4.7 Cc1ccc(Cl)c(Nc2ccccc2C(=O)O)c1Cl 10.1038/s41467-023-40064-9
CHEMBL876 189124 None 43 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 295 3 2 2 4.7 Cc1ccc(Cl)c(Nc2ccccc2C(=O)O)c1Cl 10.1038/s41467-023-40064-9
1599 2341 None 28 Human Binding pAC50 = 4.5 4.5 - 18
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
3955 2341 None 28 Human Binding pAC50 = 4.5 4.5 - 18
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
3955.0 2341 None 28 Human Binding pAC50 = 4.5 4.5 - 18
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
7215 2341 None 28 Human Binding pAC50 = 4.5 4.5 - 18
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL841 2341 None 28 Human Binding pAC50 = 4.5 4.5 - 18
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
DB00836 2341 None 28 Human Binding pAC50 = 4.5 4.5 - 18
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
16063245 167539 None 50 Human Binding pAC50 = 6.5 6.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 530 6 2 8 5.8 Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cnccn5)n4)c3)cc(C(F)(F)F)c2)cn1 10.1038/s41467-023-40064-9
CHEMBL4297524 167539 None 50 Human Binding pAC50 = 6.5 6.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 530 6 2 8 5.8 Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cnccn5)n4)c3)cc(C(F)(F)F)c2)cn1 10.1038/s41467-023-40064-9
108143 94634 None 62 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 351 3 2 2 5.0 CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(C(=O)O)cc3)ccc21 10.1038/s41467-023-40064-9
CHEMBL25202 94634 None 62 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 351 3 2 2 5.0 CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(C(=O)O)cc3)ccc21 10.1038/s41467-023-40064-9
2136 3095 None 24 Human Binding pAC50 = 4.5 4.5 - 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 10.1038/s41467-023-40064-9
4768 3095 None 24 Human Binding pAC50 = 4.5 4.5 - 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 10.1038/s41467-023-40064-9
4768.0 3095 None 24 Human Binding pAC50 = 4.5 4.5 - 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 10.1038/s41467-023-40064-9
7268 3095 None 24 Human Binding pAC50 = 4.5 4.5 - 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL753 3095 None 24 Human Binding pAC50 = 4.5 4.5 - 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 10.1038/s41467-023-40064-9
DB00925 3095 None 24 Human Binding pAC50 = 4.5 4.5 - 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 10.1038/s41467-023-40064-9
45138674 16653 None 45 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 572 6 1 7 5.7 COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1 10.1038/s41467-023-40064-9
CHEMBL1241951 16653 None 45 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 572 6 1 7 5.7 COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1 10.1038/s41467-023-40064-9
5573 67602 None 59 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 9 0 6 3.7 CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C 10.1038/s41467-023-40064-9
5573.0 67602 None 59 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 9 0 6 3.7 CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C 10.1038/s41467-023-40064-9
CHEMBL1325297 67602 None 59 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 9 0 6 3.7 CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C 10.1038/s41467-023-40064-9
CHEMBL190044 67602 None 59 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 9 0 6 3.7 CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C 10.1038/s41467-023-40064-9
DB09089 67602 None 59 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 387 9 0 6 3.7 CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C 10.1038/s41467-023-40064-9
54758501 139154 None 52 Human Binding pAC50 = 8.5 8.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 486 7 2 8 5.1 C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1 10.1038/s41467-023-40064-9
CHEMBL3786343 139154 None 52 Human Binding pAC50 = 8.5 8.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 486 7 2 8 5.1 C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1 10.1038/s41467-023-40064-9
89683805 154523 None 55 Human Binding pAC50 = 8.5 8.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 473 6 3 8 4.3 CC(C)(O)CNc1nc(Nc2ccnc(C(F)(F)F)c2)nc(-c2cccc(C(F)(F)F)n2)n1 10.1038/s41467-023-40064-9
CHEMBL3989908 154523 None 55 Human Binding pAC50 = 8.5 8.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 473 6 3 8 4.3 CC(C)(O)CNc1nc(Nc2ccnc(C(F)(F)F)c2)nc(-c2cccc(C(F)(F)F)n2)n1 10.1038/s41467-023-40064-9
135564886 14499 None 5 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
135673376 14499 None 5 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
137157436 14499 None 5 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
145948239 14499 None 5 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
71587099 14499 None 5 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
CHEMBL1201304 14499 None 5 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
176870 197941 None 62 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 393 10 1 7 3.4 C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 10.1038/s41467-023-40064-9
CHEMBL553 197941 None 62 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 393 10 1 7 3.4 C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 10.1038/s41467-023-40064-9
214 3860 None 43 Human Binding pAC50 = 4.5 4.5 - 29
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
2740 3860 None 43 Human Binding pAC50 = 4.5 4.5 - 29
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
5566 3860 None 43 Human Binding pAC50 = 4.5 4.5 - 29
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
5566.0 3860 None 43 Human Binding pAC50 = 4.5 4.5 - 29
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
66064 3860 None 43 Human Binding pAC50 = 4.5 4.5 - 29
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL422 3860 None 43 Human Binding pAC50 = 4.5 4.5 - 29
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
DB00831 3860 None 43 Human Binding pAC50 = 4.5 4.5 - 29
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
1427 2013 None 42 Human Binding pAC50 = 4.5 4.5 - 26
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
357 2013 None 42 Human Binding pAC50 = 4.5 4.5 - 26
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
3696 2013 None 42 Human Binding pAC50 = 4.5 4.5 - 26
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
CHEMBL11 2013 None 42 Human Binding pAC50 = 4.5 4.5 - 26
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
DB00458 2013 None 42 Human Binding pAC50 = 4.5 4.5 - 26
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
25181577 78248 None 44 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 574 9 2 9 5.0 CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 10.1038/s41467-023-40064-9
CHEMBL2105695 78248 None 44 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 574 9 2 9 5.0 CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 10.1038/s41467-023-40064-9
3280 48463 None 17 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 395 10 0 5 5.4 CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC 10.1038/s41467-023-40064-9
CHEMBL1555736 48463 None 17 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 395 10 0 5 5.4 CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC 10.1038/s41467-023-40064-9
2812 4781 None 63 Human Binding pAC50 = 5.5 5.5 -25 34
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 10.1038/s41467-023-40064-9
CHEMBL104 4781 None 63 Human Binding pAC50 = 5.5 5.5 -25 34
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 10.1038/s41467-023-40064-9
1836 2592 None 44 Human Binding pAC50 = 5.5 5.5 -19 15
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
3340 2592 None 44 Human Binding pAC50 = 5.5 5.5 -19 15
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
5281040 2592 None 44 Human Binding pAC50 = 5.5 5.5 -19 15
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
5281040.0 2592 None 44 Human Binding pAC50 = 5.5 5.5 -19 15
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
CHEMBL787 2592 None 44 Human Binding pAC50 = 5.5 5.5 -19 15
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
DB00471 2592 None 44 Human Binding pAC50 = 5.5 5.5 -19 15
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
644241 95239 None 68 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 529 6 2 7 6.4 Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 10.1038/s41467-023-40064-9
CHEMBL255863 95239 None 68 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 529 6 2 7 6.4 Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 10.1038/s41467-023-40064-9
2683 102943 None 17 Human Binding pAC50 = 5.5 5.5 -371 16
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 10.1038/s41467-023-40064-9
CHEMBL305906 102943 None 17 Human Binding pAC50 = 5.5 5.5 -371 16
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 10.1038/s41467-023-40064-9
CHEMBL334255 102943 None 17 Human Binding pAC50 = 5.5 5.5 -371 16
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 10.1038/s41467-023-40064-9
3767 205563 None 72 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 137 1 2 3 -0.3 NNC(=O)c1ccncc1 10.1038/s41467-023-40064-9
CHEMBL64 205563 None 72 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 137 1 2 3 -0.3 NNC(=O)c1ccncc1 10.1038/s41467-023-40064-9
5591 157623 None 57 Human Binding pAC50 = 5.5 5.5 -1 2
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 441 5 2 6 4.4 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 10.1038/s41467-023-40064-9
CHEMBL408 157623 None 57 Human Binding pAC50 = 5.5 5.5 -1 2
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 441 5 2 6 4.4 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 10.1038/s41467-023-40064-9
16063245 167539 None 50 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 530 6 2 8 5.8 Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cnccn5)n4)c3)cc(C(F)(F)F)c2)cn1 10.1038/s41467-023-40064-9
CHEMBL4297524 167539 None 50 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 530 6 2 8 5.8 Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cnccn5)n4)c3)cc(C(F)(F)F)c2)cn1 10.1038/s41467-023-40064-9
5280453 208429 None 49 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 416 6 3 3 5.7 C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O 10.1038/s41467-023-40064-9
CHEMBL846 208429 None 49 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 416 6 3 3 5.7 C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O 10.1038/s41467-023-40064-9
49843517 78325 None 41 Human Binding pAC50 = 6.5 6.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 590 13 2 6 8.5 CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC 10.1038/s41467-023-40064-9
CHEMBL2107831 78325 None 41 Human Binding pAC50 = 6.5 6.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 590 13 2 6 8.5 CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC 10.1038/s41467-023-40064-9
3830 85730 None 74 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 215 3 2 5 1.6 c1coc(CNc2ncnc3[nH]cnc23)c1 10.1038/s41467-023-40064-9
CHEMBL228792 85730 None 74 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 215 3 2 5 1.6 c1coc(CNc2ncnc3[nH]cnc23)c1 10.1038/s41467-023-40064-9
2324 77126 None 16 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 505 7 1 8 4.2 COC(=O)C1=C(C)NC(C)=C(C(=O)OC2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
CHEMBL2074972 77126 None 16 Human Binding pAC50 = 5.5 5.5 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 505 7 1 8 4.2 COC(=O)C1=C(C)NC(C)=C(C(=O)OC2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
2712 916 None 18 Human Binding pAC50 = 5.4 5.4 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 299 1 1 3 3.0 CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl 10.1038/s41467-023-40064-9
3370 916 None 18 Human Binding pAC50 = 5.4 5.4 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 299 1 1 3 3.0 CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl 10.1038/s41467-023-40064-9
594 916 None 18 Human Binding pAC50 = 5.4 5.4 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 299 1 1 3 3.0 CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl 10.1038/s41467-023-40064-9
CHEMBL451 916 None 18 Human Binding pAC50 = 5.4 5.4 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 299 1 1 3 3.0 CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl 10.1038/s41467-023-40064-9
DB00475 916 None 18 Human Binding pAC50 = 5.4 5.4 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 299 1 1 3 3.0 CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl 10.1038/s41467-023-40064-9
439693 51199 None 39 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 268 2 4 8 -1.2 OC[C@H]1O[C@@H](n2cnc3c2N=CNC[C@H]3O)C[C@@H]1O 10.1038/s41467-023-40064-9
CHEMBL1580 51199 None 39 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 268 2 4 8 -1.2 OC[C@H]1O[C@@H](n2cnc3c2N=CNC[C@H]3O)C[C@@H]1O 10.1038/s41467-023-40064-9
82146 4532 None 68 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 348 3 1 1 6.1 C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C 10.1038/s41467-023-40064-9
CHEMBL1023 4532 None 68 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 348 3 1 1 6.1 C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C 10.1038/s41467-023-40064-9
98941 46964 None 13 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 457 7 0 4 6.3 COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
CHEMBL154126 46964 None 13 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 457 7 0 4 6.3 COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
25151352 140693 None 56 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 417 5 2 4 5.2 FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1 10.1038/s41467-023-40064-9
CHEMBL3813873 140693 None 56 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 417 5 2 4 5.2 FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1 10.1038/s41467-023-40064-9
219024 3300 None 47 Human Binding pAC50 = 5.4 5.4 -18 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 390 4 5 12 -2.4 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC 10.1038/s41467-023-40064-9
219024.0 3300 None 47 Human Binding pAC50 = 5.4 5.4 -18 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 390 4 5 12 -2.4 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC 10.1038/s41467-023-40064-9
2362 3300 None 47 Human Binding pAC50 = 5.4 5.4 -18 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 390 4 5 12 -2.4 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC 10.1038/s41467-023-40064-9
5596 3300 None 47 Human Binding pAC50 = 5.4 5.4 -18 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 390 4 5 12 -2.4 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC 10.1038/s41467-023-40064-9
CHEMBL317052 3300 None 47 Human Binding pAC50 = 5.4 5.4 -18 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 390 4 5 12 -2.4 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC 10.1038/s41467-023-40064-9
DB06213 3300 None 47 Human Binding pAC50 = 5.4 5.4 -18 5
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 390 4 5 12 -2.4 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC 10.1038/s41467-023-40064-9
25102847 78250 None 62 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 501 8 2 6 5.5 COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC 10.1038/s41467-023-40064-9
CHEMBL2105717 78250 None 62 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 501 8 2 6 5.5 COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC 10.1038/s41467-023-40064-9
5430 205307 None 65 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 201 1 1 3 2.7 c1ccc2[nH]c(-c3cscn3)nc2c1 10.1038/s41467-023-40064-9
CHEMBL625 205307 None 65 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 201 1 1 3 2.7 c1ccc2[nH]c(-c3cscn3)nc2c1 10.1038/s41467-023-40064-9
104850 3330 None 58 Human Binding pAC50 = 5.4 5.4 - 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
4150 3330 None 58 Human Binding pAC50 = 5.4 5.4 - 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
743 3330 None 58 Human Binding pAC50 = 5.4 5.4 - 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
CHEMBL111 3330 None 58 Human Binding pAC50 = 5.4 5.4 - 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
DB06155 3330 None 58 Human Binding pAC50 = 5.4 5.4 - 6
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
25102847 78250 None 62 Human Binding pAC50 = 6.4 6.4 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 501 8 2 6 5.5 COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC 10.1038/s41467-023-40064-9
CHEMBL2105717 78250 None 62 Human Binding pAC50 = 6.4 6.4 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 501 8 2 6 5.5 COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC 10.1038/s41467-023-40064-9
4008 7228 None 58 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 9 5.0 COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
CHEMBL1085699 7228 None 58 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 9 5.0 COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
26098 49557 None 22 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 300 2 0 4 2.1 CCCC1C(=O)N2C(N(C)C)=Nc3ccc(C)cc3N2C1=O 10.1038/s41467-023-40064-9
CHEMBL1565476 49557 None 22 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 300 2 0 4 2.1 CCCC1C(=O)N2C(N(C)C)=Nc3ccc(C)cc3N2C1=O 10.1038/s41467-023-40064-9
1046 205109 None 68 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 123 1 1 3 -0.4 NC(=O)c1cnccn1 10.1038/s41467-023-40064-9
CHEMBL614 205109 None 68 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 123 1 1 3 -0.4 NC(=O)c1cnccn1 10.1038/s41467-023-40064-9
6729 14491 None 33 Human Binding pAC50 = 4.4 4.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 432 5 0 2 6.5 CC(C)(C)c1ccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)cc1 10.1038/s41467-023-40064-9
6729.0 14491 None 33 Human Binding pAC50 = 4.4 4.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 432 5 0 2 6.5 CC(C)(C)c1ccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)cc1 10.1038/s41467-023-40064-9
CHEMBL1201271 14491 None 33 Human Binding pAC50 = 4.4 4.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 432 5 0 2 6.5 CC(C)(C)c1ccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)cc1 10.1038/s41467-023-40064-9
DB00354 14491 None 33 Human Binding pAC50 = 4.4 4.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 432 5 0 2 6.5 CC(C)(C)c1ccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)cc1 10.1038/s41467-023-40064-9
2335 11852 None 18 Human Binding pAC50 = 5.4 5.4 - 12
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
8478 11852 None 18 Human Binding pAC50 = 5.4 5.4 - 12
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL1182210 11852 None 18 Human Binding pAC50 = 5.4 5.4 - 12
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL221753 11852 None 18 Human Binding pAC50 = 5.4 5.4 - 12
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
70695647 78242 None 0 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 300 2 1 1 5.3 C=CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCCC4[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL2105618 78242 None 0 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 300 2 1 1 5.3 C=CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCCC4[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
1222 1664 None 37 Human Binding pAC50 = 5.4 5.4 - 32
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
3396 1664 None 37 Human Binding pAC50 = 5.4 5.4 - 32
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
3396.0 1664 None 37 Human Binding pAC50 = 5.4 5.4 - 32
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
85 1664 None 37 Human Binding pAC50 = 5.4 5.4 - 32
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL46516 1664 None 37 Human Binding pAC50 = 5.4 5.4 - 32
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
DB04842 1664 None 37 Human Binding pAC50 = 5.4 5.4 - 32
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
104903 56360 None 12 Human Binding pAC50 = 5.4 5.4 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 624 6 0 8 5.5 C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1 10.1038/s41467-023-40064-9
CHEMBL1630578 56360 None 12 Human Binding pAC50 = 5.4 5.4 - 6
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 624 6 0 8 5.5 C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1 10.1038/s41467-023-40064-9
2713 207729 None 57 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
5353524 207729 None 57 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
5360566 207729 None 57 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
88536661 207729 None 57 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
9552079 207729 None 57 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1330113 207729 None 57 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL790 207729 None 57 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
71398 106495 None 32 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 302 5 4 4 3.6 C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 10.1038/s41467-023-40064-9
CHEMBL313972 106495 None 32 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 302 5 4 4 3.6 C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 10.1038/s41467-023-40064-9
2333 142422 None 66 Human Binding pAC50 = 5.4 5.4 -1 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 3 1 3 5.5 CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 10.1038/s41467-023-40064-9
CHEMBL388590 142422 None 66 Human Binding pAC50 = 5.4 5.4 -1 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 3 1 3 5.5 CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 10.1038/s41467-023-40064-9
6918155 75444 None 43 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 540 5 1 7 4.7 CC(C)C(=O)OCC(=O)[C@@]12O[C@H](C3CCCCC3)O[C@@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]12C 10.1038/s41467-023-40064-9
CHEMBL2040682 75444 None 43 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 540 5 1 7 4.7 CC(C)C(=O)OCC(=O)[C@@]12O[C@H](C3CCCCC3)O[C@@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]12C 10.1038/s41467-023-40064-9
5280343 188382 None 69 Human Binding pAC50 = 5.4 5.4 -5 32
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 302 1 5 7 2.0 O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 10.1038/s41467-023-40064-9
CHEMBL1520590 188382 None 69 Human Binding pAC50 = 5.4 5.4 -5 32
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 302 1 5 7 2.0 O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 10.1038/s41467-023-40064-9
CHEMBL50 188382 None 69 Human Binding pAC50 = 5.4 5.4 -5 32
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 302 1 5 7 2.0 O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 10.1038/s41467-023-40064-9
2284 206531 None 76 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 213 4 2 2 1.9 NCC(CC(=O)O)c1ccc(Cl)cc1 10.1038/s41467-023-40064-9
2284.0 206531 None 76 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 213 4 2 2 1.9 NCC(CC(=O)O)c1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL701 206531 None 76 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 213 4 2 2 1.9 NCC(CC(=O)O)c1ccc(Cl)cc1 10.1038/s41467-023-40064-9
DB00181 206531 None 76 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 213 4 2 2 1.9 NCC(CC(=O)O)c1ccc(Cl)cc1 10.1038/s41467-023-40064-9
9853053 120583 None 54 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 693 10 2 3 8.4 O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1 10.1038/s41467-023-40064-9
CHEMBL354541 120583 None 54 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 693 10 2 3 8.4 O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1 10.1038/s41467-023-40064-9
6450551 19218 None 60 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 386 5 2 4 4.6 CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 10.1038/s41467-023-40064-9
CHEMBL1289926 19218 None 60 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 386 5 2 4 4.6 CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 10.1038/s41467-023-40064-9
12488 1657 None 39 Human Binding pAC50 = 5.3 5.3 -22 23
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F 10.1038/s41467-023-40064-9
941361 1657 None 39 Human Binding pAC50 = 5.3 5.3 -22 23
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F 10.1038/s41467-023-40064-9
CHEMBL30008 1657 None 39 Human Binding pAC50 = 5.3 5.3 -22 23
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F 10.1038/s41467-023-40064-9
DB04841 1657 None 39 Human Binding pAC50 = 5.3 5.3 -22 23
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F 10.1038/s41467-023-40064-9
443869 78170 None 28 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 491 7 1 8 3.8 COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
CHEMBL2103761 78170 None 28 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 491 7 1 8 3.8 COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
11980903 14498 None 13 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
22526 14498 None 13 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
5281035 14498 None 13 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1201303 14498 None 13 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
71398 106495 None 32 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 302 5 4 4 3.6 C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 10.1038/s41467-023-40064-9
CHEMBL313972 106495 None 32 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 302 5 4 4 3.6 C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 10.1038/s41467-023-40064-9
5282367 95957 None 50 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 444 11 0 2 8.9 CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC1=C(C)C(=O)c2ccccc2C1=O 10.1038/s41467-023-40064-9
CHEMBL259223 95957 None 50 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 444 11 0 2 8.9 CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC1=C(C)C(=O)c2ccccc2C1=O 10.1038/s41467-023-40064-9
4485 69401 None 70 Human Binding pAC50 = 6.3 6.3 -12 8
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 346 4 1 7 2.2 COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] 10.1038/s41467-023-40064-9
CHEMBL193 69401 None 70 Human Binding pAC50 = 6.3 6.3 -12 8
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 346 4 1 7 2.2 COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] 10.1038/s41467-023-40064-9
219024 3300 None 47 Human Binding pAC50 = 6.3 6.3 -18 5
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 390 4 5 12 -2.4 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC 10.1038/s41467-023-40064-9
219024.0 3300 None 47 Human Binding pAC50 = 6.3 6.3 -18 5
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 390 4 5 12 -2.4 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC 10.1038/s41467-023-40064-9
2362 3300 None 47 Human Binding pAC50 = 6.3 6.3 -18 5
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 390 4 5 12 -2.4 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC 10.1038/s41467-023-40064-9
5596 3300 None 47 Human Binding pAC50 = 6.3 6.3 -18 5
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 390 4 5 12 -2.4 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC 10.1038/s41467-023-40064-9
CHEMBL317052 3300 None 47 Human Binding pAC50 = 6.3 6.3 -18 5
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 390 4 5 12 -2.4 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC 10.1038/s41467-023-40064-9
DB06213 3300 None 47 Human Binding pAC50 = 6.3 6.3 -18 5
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 390 4 5 12 -2.4 OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC 10.1038/s41467-023-40064-9
5282138 173226 None 59 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 492 10 1 8 4.3 COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC/C=C/c2ccccc2)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
CHEMBL452076 173226 None 59 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 492 10 1 8 4.3 COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC/C=C/c2ccccc2)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
16362 3125 None 49 Human Binding pAC50 = 5.3 5.3 - 29
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
16362.0 3125 None 49 Human Binding pAC50 = 5.3 5.3 - 29
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
2172 3125 None 49 Human Binding pAC50 = 5.3 5.3 - 29
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
90 3125 None 49 Human Binding pAC50 = 5.3 5.3 - 29
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL1423 3125 None 49 Human Binding pAC50 = 5.3 5.3 - 29
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB01100 3125 None 49 Human Binding pAC50 = 5.3 5.3 - 29
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
41684 31229 None 62 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
CHEMBL1401 31229 None 62 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
31315 93461 None 51 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 317 2 3 3 3.4 O=C1Nc2ccccc2C1(c1ccc(O)cc1)c1ccc(O)cc1 10.1038/s41467-023-40064-9
CHEMBL245807 93461 None 51 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 317 2 3 3 3.4 O=C1Nc2ccccc2C1(c1ccc(O)cc1)c1ccc(O)cc1 10.1038/s41467-023-40064-9
6509979 14440 None 35 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 809 6 2 11 5.7 CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@H](Cl)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC 10.1038/s41467-023-40064-9
CHEMBL1200686 14440 None 35 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 809 6 2 11 5.7 CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@H](Cl)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC 10.1038/s41467-023-40064-9
5050 78229 None 41 Human Binding pAC50 = 7.3 7.3 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 355 4 1 5 3.5 Cc1ccc2c([nH]c(=O)c3c(=O)cc(C(=O)OCCC(C)C)oc32)c1C 10.1038/s41467-023-40064-9
CHEMBL2105300 78229 None 41 Human Binding pAC50 = 7.3 7.3 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 355 4 1 5 3.5 Cc1ccc2c([nH]c(=O)c3c(=O)cc(C(=O)OCCC(C)C)oc32)c1C 10.1038/s41467-023-40064-9
5318 15583 None 40 Human Binding pAC50 = 5.3 5.3 -1 13
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1200348 15583 None 40 Human Binding pAC50 = 5.3 5.3 -1 13
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1221 15583 None 40 Human Binding pAC50 = 5.3 5.3 -1 13
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 10.1038/s41467-023-40064-9
71496458 115628 None 61 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 499 10 2 8 4.5 C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C 10.1038/s41467-023-40064-9
CHEMBL3353410 115628 None 61 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 499 10 2 8 4.5 C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C 10.1038/s41467-023-40064-9
3354 41798 None 37 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 391 5 0 5 4.4 Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O 10.1038/s41467-023-40064-9
3354.0 41798 None 37 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 391 5 0 5 4.4 Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O 10.1038/s41467-023-40064-9
CHEMBL1493 41798 None 37 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 391 5 0 5 4.4 Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O 10.1038/s41467-023-40064-9
DB01148 41798 None 37 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 391 5 0 5 4.4 Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O 10.1038/s41467-023-40064-9
72093 35070 None 5 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL1433361 35070 None 5 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL2103773 35070 None 5 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
2335 11852 None 18 Human Binding pAC50 = 5.3 5.3 - 12
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
8478 11852 None 18 Human Binding pAC50 = 5.3 5.3 - 12
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL1182210 11852 None 18 Human Binding pAC50 = 5.3 5.3 - 12
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL221753 11852 None 18 Human Binding pAC50 = 5.3 5.3 - 12
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
71398 106495 None 32 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 302 5 4 4 3.6 C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 10.1038/s41467-023-40064-9
CHEMBL313972 106495 None 32 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 302 5 4 4 3.6 C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 10.1038/s41467-023-40064-9
5282219 35878 None 48 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 450 12 1 5 5.7 CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1 10.1038/s41467-023-40064-9
CHEMBL1441961 35878 None 48 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 450 12 1 5 5.7 CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1 10.1038/s41467-023-40064-9
5282493 14455 None 28 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 494 3 1 5 4.6 C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@H]1C(=O)COC(=O)C(C)(C)C 10.1038/s41467-023-40064-9
CHEMBL1200975 14455 None 28 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 494 3 1 5 4.6 C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@H]1C(=O)COC(=O)C(C)(C)C 10.1038/s41467-023-40064-9
5282175 14437 None 23 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 16 2 5 5.1 CCCCCCCC(=O)CC[C@@H]1[C@@H](C/C=C\CCCC(=O)OC(C)C)[C@@H](O)C[C@H]1O 10.1038/s41467-023-40064-9
CHEMBL1200661 14437 None 23 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 16 2 5 5.1 CCCCCCCC(=O)CC[C@@H]1[C@@H](C/C=C\CCCC(=O)OC(C)C)[C@@H](O)C[C@H]1O 10.1038/s41467-023-40064-9
216416 111644 None 40 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 413 6 1 3 5.7 Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
CHEMBL328190 111644 None 40 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 413 6 1 3 5.7 Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
154257 178724 None 43 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 470 7 2 5 6.3 Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12 10.1038/s41467-023-40064-9
CHEMBL46740 178724 None 43 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 470 7 2 5 6.3 Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12 10.1038/s41467-023-40064-9
64139 84819 None 58 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 0 1 2 4.1 O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 10.1038/s41467-023-40064-9
CHEMBL223228 84819 None 58 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 0 1 2 4.1 O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 10.1038/s41467-023-40064-9
40973 46049 None 50 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 310 1 1 1 4.9 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC 10.1038/s41467-023-40064-9
CHEMBL1533 46049 None 50 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 310 1 1 1 4.9 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC 10.1038/s41467-023-40064-9
CHEMBL2103737 78169 None 0 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None None 10.1038/s41467-023-40064-9
4499 59795 None 61 Human Binding pAC50 = 6.2 6.2 -1 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 388 6 1 7 3.2 COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1ccccc1[N+](=O)[O-] 10.1038/s41467-023-40064-9
CHEMBL1726 59795 None 61 Human Binding pAC50 = 6.2 6.2 -1 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 388 6 1 7 3.2 COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1ccccc1[N+](=O)[O-] 10.1038/s41467-023-40064-9
54454 5260 None 48 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 418 6 1 5 4.6 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
CHEMBL1064 5260 None 48 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 418 6 1 5 4.6 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
21700 593 None 36 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 520 6 1 7 4.1 CCC(=O)O[C@@]1([C@@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)Cl)C(=O)COC(=O)CC 10.1038/s41467-023-40064-9
294 593 None 36 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 520 6 1 7 4.1 CCC(=O)O[C@@]1([C@@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)Cl)C(=O)COC(=O)CC 10.1038/s41467-023-40064-9
5894 593 None 36 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 520 6 1 7 4.1 CCC(=O)O[C@@]1([C@@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)Cl)C(=O)COC(=O)CC 10.1038/s41467-023-40064-9
CHEMBL1200500 593 None 36 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 520 6 1 7 4.1 CCC(=O)O[C@@]1([C@@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)Cl)C(=O)COC(=O)CC 10.1038/s41467-023-40064-9
DB00394 593 None 36 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 520 6 1 7 4.1 CCC(=O)O[C@@]1([C@@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)Cl)C(=O)COC(=O)CC 10.1038/s41467-023-40064-9
150311 9814 None 69 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 409 6 2 3 4.9 O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc1 10.1038/s41467-023-40064-9
CHEMBL1138 9814 None 69 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 409 6 2 3 4.9 O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc1 10.1038/s41467-023-40064-9
213046 2385 None 44 Human Binding pAC50 = 5.2 5.2 - 8
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1038/s41467-023-40064-9
213046.0 2385 None 44 Human Binding pAC50 = 5.2 5.2 - 8
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1038/s41467-023-40064-9
4168 2385 None 44 Human Binding pAC50 = 5.2 5.2 - 8
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1038/s41467-023-40064-9
7461 2385 None 44 Human Binding pAC50 = 5.2 5.2 - 8
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1038/s41467-023-40064-9
CHEMBL1237021 2385 None 44 Human Binding pAC50 = 5.2 5.2 - 8
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1038/s41467-023-40064-9
DB08815 2385 None 44 Human Binding pAC50 = 5.2 5.2 - 8
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1038/s41467-023-40064-9
51755 57422 None 40 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 454 8 0 4 7.3 Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 10.1038/s41467-023-40064-9
CHEMBL1651990 57422 None 40 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 454 8 0 4 7.3 Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 10.1038/s41467-023-40064-9
54682461 84720 None 41 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 602 11 2 6 7.3 CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 10.1038/s41467-023-40064-9
CHEMBL222559 84720 None 41 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 602 11 2 6 7.3 CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 10.1038/s41467-023-40064-9
5482 14425 None 55 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 386 6 0 4 5.9 Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1 10.1038/s41467-023-40064-9
CHEMBL1200438 14425 None 55 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 386 6 0 4 5.9 Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1 10.1038/s41467-023-40064-9
5440 28732 None 28 Human Binding pAC50 = 5.2 5.2 - 9
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 399 6 0 5 5.0 CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2 10.1038/s41467-023-40064-9
5440.0 28732 None 28 Human Binding pAC50 = 5.2 5.2 - 9
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 399 6 0 5 5.0 CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2 10.1038/s41467-023-40064-9
CHEMBL1378 28732 None 28 Human Binding pAC50 = 5.2 5.2 - 9
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 399 6 0 5 5.0 CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2 10.1038/s41467-023-40064-9
DB00372 28732 None 28 Human Binding pAC50 = 5.2 5.2 - 9
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 399 6 0 5 5.0 CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2 10.1038/s41467-023-40064-9
228 445 None 20 Human Binding pAC50 = 6.2 6.2 - 24
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
33 445 None 20 Human Binding pAC50 = 6.2 6.2 - 24
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
6005 445 None 20 Human Binding pAC50 = 6.2 6.2 - 24
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
6005.0 445 None 20 Human Binding pAC50 = 6.2 6.2 - 24
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
CHEMBL53 445 None 20 Human Binding pAC50 = 6.2 6.2 - 24
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
DB00714 445 None 20 Human Binding pAC50 = 6.2 6.2 - 24
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
13791 43805 None 46 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 356 4 1 3 5.4 CCCCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@]12C 10.1038/s41467-023-40064-9
CHEMBL1511 43805 None 46 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 356 4 1 3 5.4 CCCCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@]12C 10.1038/s41467-023-40064-9
31101 729 None 28 Human Binding pAC50 = 5.2 5.2 - 35
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
31101.0 729 None 28 Human Binding pAC50 = 5.2 5.2 - 35
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
35 729 None 28 Human Binding pAC50 = 5.2 5.2 - 35
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
403 729 None 28 Human Binding pAC50 = 5.2 5.2 - 35
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
CHEMBL493 729 None 28 Human Binding pAC50 = 5.2 5.2 - 35
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
DB01200 729 None 28 Human Binding pAC50 = 5.2 5.2 - 35
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
16722836 18992 None 63 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 524 10 3 8 4.8 Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 10.1038/s41467-023-40064-9
CHEMBL1287853 18992 None 63 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 524 10 3 8 4.8 Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 10.1038/s41467-023-40064-9
242 470 None 70 Human Binding pAC50 = 5.2 5.2 - 51
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
34 470 None 70 Human Binding pAC50 = 5.2 5.2 - 51
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
60795 470 None 70 Human Binding pAC50 = 5.2 5.2 - 51
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
60795.0 470 None 70 Human Binding pAC50 = 5.2 5.2 - 51
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
CHEMBL1112 470 None 70 Human Binding pAC50 = 5.2 5.2 - 51
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
DB01238 470 None 70 Human Binding pAC50 = 5.2 5.2 - 51
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
4046 2483 None 21 Human Binding pAC50 = 5.2 5.2 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
4252 2483 None 21 Human Binding pAC50 = 5.2 5.2 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
CHEMBL416956 2483 None 21 Human Binding pAC50 = 5.2 5.2 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
DB00358 2483 None 21 Human Binding pAC50 = 5.2 5.2 - 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
6719 32676 None 23 Human Binding pAC50 = 6.1 6.1 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 340 4 0 3 4.1 O=C1c2ccccc2C(=O)C1C(=O)C(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1413199 32676 None 23 Human Binding pAC50 = 6.1 6.1 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 340 4 0 3 4.1 O=C1c2ccccc2C(=O)C1C(=O)C(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
3474 38112 None 43 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 372 6 3 6 3.1 O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12 10.1038/s41467-023-40064-9
CHEMBL146095 38112 None 43 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 372 6 3 6 3.1 O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12 10.1038/s41467-023-40064-9
667476 4472 None 45 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 266 3 2 2 4.6 C/C=C(C(=C/C)/c1ccc(O)cc1)\c1ccc(O)cc1 10.1038/s41467-023-40064-9
CHEMBL1018 4472 None 45 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 266 3 2 2 4.6 C/C=C(C(=C/C)/c1ccc(O)cc1)\c1ccc(O)cc1 10.1038/s41467-023-40064-9
24826799 10802 None 64 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 532 4 1 6 4.5 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 10.1038/s41467-023-40064-9
CHEMBL1171837 10802 None 64 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 532 4 1 6 4.5 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 10.1038/s41467-023-40064-9
5486699 107495 None 45 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 742 15 10 19 -2.7 C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(-c4ccc(OCCO)c(OCCO)c4)oc4cc(OCCO)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O 10.1038/s41467-023-40064-9
CHEMBL3182320 107495 None 45 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 742 15 10 19 -2.7 C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(-c4ccc(OCCO)c(OCCO)c4)oc4cc(OCCO)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O 10.1038/s41467-023-40064-9
5803 162321 None 58 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 622 4 2 3 4.6 O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 10.1038/s41467-023-40064-9
CHEMBL41632 162321 None 58 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 622 4 2 3 4.6 O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 10.1038/s41467-023-40064-9
4034 55838 None 37 Human Binding pAC50 = 5.1 5.1 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 390 5 0 2 5.6 Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1 10.1038/s41467-023-40064-9
4034.0 55838 None 37 Human Binding pAC50 = 5.1 5.1 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 390 5 0 2 5.6 Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1 10.1038/s41467-023-40064-9
CHEMBL1623 55838 None 37 Human Binding pAC50 = 5.1 5.1 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 390 5 0 2 5.6 Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1 10.1038/s41467-023-40064-9
DB00737 55838 None 37 Human Binding pAC50 = 5.1 5.1 - 1
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 390 5 0 2 5.6 Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1 10.1038/s41467-023-40064-9
439280 120083 None 57 Human Binding pAC50 = 6.1 6.1 - 2
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 220 3 4 3 0.8 N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O 10.1038/s41467-023-40064-9
6971044 120083 None 57 Human Binding pAC50 = 6.1 6.1 - 2
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 220 3 4 3 0.8 N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL350221 120083 None 57 Human Binding pAC50 = 6.1 6.1 - 2
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 220 3 4 3 0.8 N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O 10.1038/s41467-023-40064-9
2194 63103 None 64 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 240 2 0 4 4.2 COc1ccc(-c2cc(=S)ss2)cc1 10.1038/s41467-023-40064-9
CHEMBL178862 63103 None 64 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 240 2 0 4 4.2 COc1ccc(-c2cc(=S)ss2)cc1 10.1038/s41467-023-40064-9
3883 183641 None 69 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 5 1 4 3.5 Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1 10.1038/s41467-023-40064-9
CHEMBL480 183641 None 69 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 5 1 4 3.5 Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1 10.1038/s41467-023-40064-9
15942715 78222 None 18 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 446 5 1 5 4.0 CCCCOC(=O)C(=O)[C@H]1[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL2105087 78222 None 18 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 446 5 1 5 4.0 CCCCOC(=O)C(=O)[C@H]1[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C 10.1038/s41467-023-40064-9
259329 60524 None 23 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 519 7 2 4 5.3 C[C@]12CC[C@@H]3c4ccc(OC(=O)N(CCCl)CCCl)cc4CC[C@H]3[C@@H]1CC[C@@H]2OP(=O)(O)O 10.1038/s41467-023-40064-9
CHEMBL1756 60524 None 23 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 519 7 2 4 5.3 C[C@]12CC[C@@H]3c4ccc(OC(=O)N(CCCl)CCCl)cc4CC[C@H]3[C@@H]1CC[C@@H]2OP(=O)(O)O 10.1038/s41467-023-40064-9
448537 160344 None 54 Human Binding pAC50 = 5.1 5.1 -16 25
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 10.1038/s41467-023-40064-9
CHEMBL411 160344 None 54 Human Binding pAC50 = 5.1 5.1 -16 25
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 10.1038/s41467-023-40064-9
5077 3578 None 61 Human Binding pAC50 = 5.1 5.1 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
7552 3578 None 61 Human Binding pAC50 = 5.1 5.1 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
9913767 3578 None 61 Human Binding pAC50 = 5.1 5.1 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
9913767.0 3578 None 61 Human Binding pAC50 = 5.1 5.1 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
CHEMBL238804 3578 None 61 Human Binding pAC50 = 5.1 5.1 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
DB11362 3578 None 61 Human Binding pAC50 = 5.1 5.1 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
3333 40181 None 69 Human Binding pAC50 = 5.1 5.1 - 1
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 5 4.0 CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1Cl 10.1038/s41467-023-40064-9
CHEMBL1480 40181 None 69 Human Binding pAC50 = 5.1 5.1 - 1
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 5 4.0 CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1Cl 10.1038/s41467-023-40064-9
10374 72356 None 46 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 221 2 2 5 1.9 Nc1ncnc(Nc2ccc(Cl)cc2)n1 10.1038/s41467-023-40064-9
CHEMBL1984344 72356 None 46 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 221 2 2 5 1.9 Nc1ncnc(Nc2ccc(Cl)cc2)n1 10.1038/s41467-023-40064-9
156419 938 None 48 Human Binding pAC50 = 5.1 5.1 - 15
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
156419.0 938 None 48 Human Binding pAC50 = 5.1 5.1 - 15
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
3308 938 None 48 Human Binding pAC50 = 5.1 5.1 - 15
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
647 938 None 48 Human Binding pAC50 = 5.1 5.1 - 15
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL1201284 938 None 48 Human Binding pAC50 = 5.1 5.1 - 15
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
DB01012 938 None 48 Human Binding pAC50 = 5.1 5.1 - 15
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
444008 78173 None 31 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 312 0 1 2 3.9 C#C[C@]1(O)CC[C@H]2[C@@H]3[C@H](C)CC4=C(CCC(=O)C4)[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL2103774 78173 None 31 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 312 0 1 2 3.9 C#C[C@]1(O)CC[C@H]2[C@@H]3[C@H](C)CC4=C(CCC(=O)C4)[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
1605 2342 None 72 Human Binding pAC50 = 5.1 5.1 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 1 0 3 4.9 CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 10.1038/s41467-023-40064-9
3957 2342 None 72 Human Binding pAC50 = 5.1 5.1 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 1 0 3 4.9 CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 10.1038/s41467-023-40064-9
3957.0 2342 None 72 Human Binding pAC50 = 5.1 5.1 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 1 0 3 4.9 CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 10.1038/s41467-023-40064-9
7216 2342 None 72 Human Binding pAC50 = 5.1 5.1 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 1 0 3 4.9 CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 10.1038/s41467-023-40064-9
CHEMBL998 2342 None 72 Human Binding pAC50 = 5.1 5.1 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 1 0 3 4.9 CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 10.1038/s41467-023-40064-9
DB00455 2342 None 72 Human Binding pAC50 = 5.1 5.1 - 4
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 1 0 3 4.9 CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 10.1038/s41467-023-40064-9
5281034 14431 None 18 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 332 0 2 3 4.4 C[C@]12C/C(=C/O)C(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O 10.1038/s41467-023-40064-9
CHEMBL1200585 14431 None 18 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 332 0 2 3 4.4 C[C@]12C/C(=C/O)C(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O 10.1038/s41467-023-40064-9
444795 140086 None 62 Human Binding pAC50 = 5.1 5.1 -3 2
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 300 5 1 1 5.6 CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 10.1038/s41467-023-40064-9
CHEMBL38 140086 None 62 Human Binding pAC50 = 5.1 5.1 -3 2
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 300 5 1 1 5.6 CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 10.1038/s41467-023-40064-9
24821094 67115 None 58 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 440 5 1 7 4.2 C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 10.1038/s41467-023-40064-9
CHEMBL1873475 67115 None 58 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 440 5 1 7 4.2 C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 10.1038/s41467-023-40064-9
5832 14466 None 37 Human Binding pAC50 = 6.1 6.1 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 340 1 0 3 4.1 C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
CHEMBL1201146 14466 None 37 Human Binding pAC50 = 6.1 6.1 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 340 1 0 3 4.1 C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C 10.1038/s41467-023-40064-9
5329102 194838 None 50 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
CHEMBL535 194838 None 50 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
3606 205946 None 40 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 270 5 2 2 4.8 CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1 10.1038/s41467-023-40064-9
CHEMBL6615 205946 None 40 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 270 5 2 2 4.8 CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1 10.1038/s41467-023-40064-9
5591 157623 None 57 Human Binding pAC50 = 5.1 5.1 -1 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 441 5 2 6 4.4 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 10.1038/s41467-023-40064-9
CHEMBL408 157623 None 57 Human Binding pAC50 = 5.1 5.1 -1 2
Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 441 5 2 6 4.4 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 10.1038/s41467-023-40064-9
135973538 3710 None 26 Human Binding pAC50 = 5.1 5.1 - 2
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 1296 16 12 17 6.7 O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O 10.1038/s41467-023-40064-9
1728 3710 None 26 Human Binding pAC50 = 5.1 5.1 - 2
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 1296 16 12 17 6.7 O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O 10.1038/s41467-023-40064-9
2966 3710 None 26 Human Binding pAC50 = 5.1 5.1 - 2
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 1296 16 12 17 6.7 O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O 10.1038/s41467-023-40064-9
4261196 3710 None 26 Human Binding pAC50 = 5.1 5.1 - 2
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 1296 16 12 17 6.7 O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O 10.1038/s41467-023-40064-9
5361 3710 None 26 Human Binding pAC50 = 5.1 5.1 - 2
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 1296 16 12 17 6.7 O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O 10.1038/s41467-023-40064-9
5361.0 3710 None 26 Human Binding pAC50 = 5.1 5.1 - 2
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 1296 16 12 17 6.7 O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O 10.1038/s41467-023-40064-9
CHEMBL265502 3710 None 26 Human Binding pAC50 = 5.1 5.1 - 2
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 1296 16 12 17 6.7 O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O 10.1038/s41467-023-40064-9
DB04786 3710 None 26 Human Binding pAC50 = 5.1 5.1 - 2
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 1296 16 12 17 6.7 O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O 10.1038/s41467-023-40064-9
2865 4143 None 47 Human Binding pAC50 = 5.1 5.1 - 53
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
59 4143 None 47 Human Binding pAC50 = 5.1 5.1 - 53
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
60854 4143 None 47 Human Binding pAC50 = 5.1 5.1 - 53
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
60854.0 4143 None 47 Human Binding pAC50 = 5.1 5.1 - 53
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL708 4143 None 47 Human Binding pAC50 = 5.1 5.1 - 53
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s41467-023-40064-9
DB00246 4143 None 47 Human Binding pAC50 = 5.1 5.1 - 53
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
ChEMBL 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 10.1038/s4