Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 154634333 | 185321 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 352 | 2 | 2 | 6 | 2.4 | O=C(O)c1cc2c3ccccc3c3cc(C(=O)O)c(=O)oc3c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4857772 | 185321 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 352 | 2 | 2 | 6 | 2.4 | O=C(O)c1cc2c3ccccc3c3cc(C(=O)O)c(=O)oc3c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 326869 | 112874 | None | 2 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 314 | 2 | 4 | 4 | 1.1 | Cc1c2[nH]c(C(=O)O)cc(=O)c2cc2c(=O)cc(C(=O)O)[nH]c12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL3306990 | 112874 | None | 2 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 314 | 2 | 4 | 4 | 1.1 | Cc1c2[nH]c(C(=O)O)cc(=O)c2cc2c(=O)cc(C(=O)O)[nH]c12 | 10.1021/acs.jmedchem.0c01624 | |||
| 164610101 | 184981 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 342 | 4 | 2 | 6 | 2.5 | COc1cc(C(=O)O)nc2c(C)c3nc(C(=O)O)cc(OC)c3cc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4852667 | 184981 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 342 | 4 | 2 | 6 | 2.5 | COc1cc(C(=O)O)nc2c(C)c3nc(C(=O)O)cc(OC)c3cc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 135399235 | 4134 | None | 41 | Mouse | Functional | pEC50 | = | 6 | 6.0 | -31 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmc.2023.117511 | |||
| 2919 | 4134 | None | 41 | Mouse | Functional | pEC50 | = | 6 | 6.0 | -31 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmc.2023.117511 | |||
| 5722 | 4134 | None | 41 | Mouse | Functional | pEC50 | = | 6 | 6.0 | -31 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL28079 | 4134 | None | 41 | Mouse | Functional | pEC50 | = | 6 | 6.0 | -31 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmc.2023.117511 | |||
| 12138435 | 68079 | None | 26 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 329 | 1 | 0 | 4 | 4.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1 | 10.1021/jm200999f | |||
| CHEMBL1914576 | 68079 | None | 26 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 329 | 1 | 0 | 4 | 4.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1 | 10.1021/jm200999f | |||
| 70696510 | 75329 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 296 | 1 | 1 | 3 | 4.1 | O=C(O)c1sc2c(Br)csc2c1Cl | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037458 | 75329 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 296 | 1 | 1 | 3 | 4.1 | O=C(O)c1sc2c(Br)csc2c1Cl | 10.1016/j.bmcl.2012.04.057 | |||
| 70682869 | 77410 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 275 | 2 | 4 | 4 | 3.0 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1ccsc1 | 10.1021/ml300076u | |||
| CHEMBL2086422 | 77410 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 275 | 2 | 4 | 4 | 3.0 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1ccsc1 | 10.1021/ml300076u | |||
| 5281605 | 208190 | None | 72 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 270 | 1 | 3 | 5 | 2.6 | O=c1cc(-c2ccccc2)oc2cc(O)c(O)c(O)c12 | 10.1021/ml2003058 | |||
| CHEMBL8260 | 208190 | None | 72 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 270 | 1 | 3 | 5 | 2.6 | O=c1cc(-c2ccccc2)oc2cc(O)c(O)c(O)c12 | 10.1021/ml2003058 | |||
| 172462775 | 196680 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -8 | 2 | ChEMBL | 490 | 4 | 2 | 6 | 4.2 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CCCC2)c1Cl)C(=O)OC1CCCC1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5429740 | 196680 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -8 | 2 | ChEMBL | 490 | 4 | 2 | 6 | 4.2 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CCCC2)c1Cl)C(=O)OC1CCCC1 | 10.1016/j.bmc.2023.117511 | |||
| 145950576 | 162974 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 333 | 3 | 2 | 5 | 2.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccco1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4173352 | 162974 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 333 | 3 | 2 | 5 | 2.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccco1 | 10.1021/acsmedchemlett.7b00510 | |||
| 70687103 | 77731 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 337 | 2 | 4 | 3 | 4.3 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1cc(Cl)cc(Cl)c1 | 10.1021/ml300076u | |||
| CHEMBL2089222 | 77731 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 337 | 2 | 4 | 3 | 4.3 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1cc(Cl)cc(Cl)c1 | 10.1021/ml300076u | |||
| 70687102 | 77730 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 313 | 3 | 5 | 4 | 2.6 | O=C(O)c1ccc(-c2c(C(=O)O)[nH]c3cc(O)c(O)cc23)cc1 | 10.1021/ml300076u | |||
| CHEMBL2089221 | 77730 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 313 | 3 | 5 | 4 | 2.6 | O=C(O)c1ccc(-c2c(C(=O)O)[nH]c3cc(O)c(O)cc23)cc1 | 10.1021/ml300076u | |||
| 5281855 | 205301 | None | 65 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 302 | 0 | 4 | 8 | 1.3 | O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23 | 10.1021/ml2003058 | |||
| CHEMBL6246 | 205301 | None | 65 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 302 | 0 | 4 | 8 | 1.3 | O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23 | 10.1021/ml2003058 | |||
| 53257379 | 68083 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 363 | 1 | 0 | 4 | 5.0 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1Cl | 10.1021/jm200999f | |||
| CHEMBL1914580 | 68083 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 363 | 1 | 0 | 4 | 5.0 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1Cl | 10.1021/jm200999f | |||
| 135403802 | 26539 | None | 39 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 300 | 0 | 4 | 6 | 1.3 | O=C1C=C2CC3(O)COc4c(ccc(O)c4O)C3=C2C=C1O | 10.1021/ml2003058 | |||
| CHEMBL1360563 | 26539 | None | 39 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 300 | 0 | 4 | 6 | 1.3 | O=C1C=C2CC3(O)COc4c(ccc(O)c4O)C3=C2C=C1O | 10.1021/ml2003058 | |||
| 411 | 2593 | None | 63 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -144 | 2 | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | Oc1ccc(c(c1)O)c1oc2cc(O)cc(c2c(=O)c1O)O | 10.1021/ml2003058 | |||
| 5281670 | 2593 | None | 63 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -144 | 2 | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | Oc1ccc(c(c1)O)c1oc2cc(O)cc(c2c(=O)c1O)O | 10.1021/ml2003058 | |||
| CHEMBL28626 | 2593 | None | 63 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -144 | 2 | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | Oc1ccc(c(c1)O)c1oc2cc(O)cc(c2c(=O)c1O)O | 10.1021/ml2003058 | |||
| 4488 | 205479 | None | 66 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | 10.1021/ml2003058 | |||
| CHEMBL63323 | 205479 | None | 66 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | 10.1021/ml2003058 | |||
| 70692387 | 75336 | None | 2 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 259 | 1 | 2 | 2 | 3.0 | Cc1c(C(=O)O)[nH]c2c(Br)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037465 | 75336 | None | 2 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 259 | 1 | 2 | 2 | 3.0 | Cc1c(C(=O)O)[nH]c2c(Br)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 66561718 | 75333 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 275 | 2 | 1 | 4 | 4.0 | Cc1c(C(=O)O)sc2c(-c3cccnc3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037462 | 75333 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 275 | 2 | 1 | 4 | 4.0 | Cc1c(C(=O)O)sc2c(-c3cccnc3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 172457931 | 196452 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | -1 | 2 | ChEMBL | 434 | 4 | 2 | 6 | 2.6 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CC2)c1Cl)C(=O)OC1CC1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5424229 | 196452 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | -1 | 2 | ChEMBL | 434 | 4 | 2 | 6 | 2.6 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CC2)c1Cl)C(=O)OC1CC1 | 10.1016/j.bmc.2023.117511 | |||
| 71733843 | 90890 | None | 7 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 87 | 3 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL2392174 | 90890 | None | 7 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 87 | 3 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL2425818 | 90890 | None | 7 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 87 | 3 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1016/j.bmc.2023.117511 | |||
| 172452315 | 196082 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | 11 | 2 | ChEMBL | 320 | 2 | 4 | 4 | 0.8 | O=C(O)C(=O)Nc1cc(NC(=O)C(=O)O)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5416593 | 196082 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | 11 | 2 | ChEMBL | 320 | 2 | 4 | 4 | 0.8 | O=C(O)C(=O)Nc1cc(NC(=O)C(=O)O)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2023.117511 | |||
| 154634327 | 184845 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 380 | 2 | 2 | 6 | 2.1 | O=C(O)c1cc2cc3cc(C(=O)O)c(=O)oc3c(Br)c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4850743 | 184845 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 380 | 2 | 2 | 6 | 2.1 | O=C(O)c1cc2cc3cc(C(=O)O)c(=O)oc3c(Br)c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 153273978 | 198382 | None | 6 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 248 | 1 | 4 | 5 | 1.0 | O=C(O)c1cc(O)c(=O)c2c(O)c(O)ccc2c1 | 10.1021/ml2003058 | |||
| 5098885 | 198382 | None | 6 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 248 | 1 | 4 | 5 | 1.0 | O=C(O)c1cc(O)c(=O)c2c(O)c(O)ccc2c1 | 10.1021/ml2003058 | |||
| CHEMBL559337 | 198382 | None | 6 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 248 | 1 | 4 | 5 | 1.0 | O=C(O)c1cc(O)c(=O)c2c(O)c(O)ccc2c1 | 10.1021/ml2003058 | |||
| 12897316 | 196999 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 41 | 2 | ChEMBL | 330 | 3 | 5 | 5 | 0.1 | O=C(O)C(=O)Nc1cc(C(=O)O)cc(NC(=O)C(=O)O)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5436420 | 196999 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 41 | 2 | ChEMBL | 330 | 3 | 5 | 5 | 0.1 | O=C(O)C(=O)Nc1cc(C(=O)O)cc(NC(=O)C(=O)O)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 172462775 | 196680 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | 8 | 2 | ChEMBL | 490 | 4 | 2 | 6 | 4.2 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CCCC2)c1Cl)C(=O)OC1CCCC1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5429740 | 196680 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | 8 | 2 | ChEMBL | 490 | 4 | 2 | 6 | 4.2 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CCCC2)c1Cl)C(=O)OC1CCCC1 | 10.1016/j.bmc.2023.117511 | |||
| 70681838 | 75325 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 290 | 1 | 1 | 3 | 4.0 | Cc1sc2c(C)c(C(=O)O)sc2c1Br | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037453 | 75325 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 290 | 1 | 1 | 3 | 4.0 | Cc1sc2c(C)c(C(=O)O)sc2c1Br | 10.1016/j.bmcl.2012.04.057 | |||
| 70689185 | 77734 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 337 | 2 | 4 | 3 | 4.0 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1ccc(C(F)(F)F)cc1 | 10.1021/ml300076u | |||
| CHEMBL2089225 | 77734 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 337 | 2 | 4 | 3 | 4.0 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1ccc(C(F)(F)F)cc1 | 10.1021/ml300076u | |||
| 72103 | 43422 | None | 23 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 356 | 5 | 4 | 4 | 2.1 | CCCCc1cc2c(=O)cc(C(=O)O)[nH]c2c2c(=O)cc(C(=O)O)[nH]c12 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL150764 | 43422 | None | 23 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 356 | 5 | 4 | 4 | 2.1 | CCCCc1cc2c(=O)cc(C(=O)O)[nH]c2c2c(=O)cc(C(=O)O)[nH]c12 | 10.1016/j.bmc.2023.117511 | |||
| 72103 | 43422 | None | 23 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 356 | 5 | 4 | 4 | 2.1 | CCCCc1cc2c(=O)cc(C(=O)O)[nH]c2c2c(=O)cc(C(=O)O)[nH]c12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL150764 | 43422 | None | 23 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 356 | 5 | 4 | 4 | 2.1 | CCCCc1cc2c(=O)cc(C(=O)O)[nH]c2c2c(=O)cc(C(=O)O)[nH]c12 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634331 | 184654 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 420 | 4 | 2 | 6 | 4.1 | CC(C)c1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4848109 | 184654 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 420 | 4 | 2 | 6 | 4.1 | CC(C)c1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 145951566 | 162860 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 379 | 3 | 2 | 4 | 3.2 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(F)cc1F | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4171782 | 162860 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 379 | 3 | 2 | 4 | 3.2 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(F)cc1F | 10.1021/acsmedchemlett.7b00510 | |||
| 145951566 | 162860 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 379 | 3 | 2 | 4 | 3.2 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(F)cc1F | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4171782 | 162860 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 379 | 3 | 2 | 4 | 3.2 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(F)cc1F | 10.1021/acsmedchemlett.7b00510 | |||
| 145959592 | 162444 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.2 | Cc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4164993 | 162444 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.2 | Cc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 411 | 2593 | None | 63 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -144 | 2 | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | Oc1ccc(c(c1)O)c1oc2cc(O)cc(c2c(=O)c1O)O | 10.1021/ml2003058 | |||
| 5281670 | 2593 | None | 63 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -144 | 2 | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | Oc1ccc(c(c1)O)c1oc2cc(O)cc(c2c(=O)c1O)O | 10.1021/ml2003058 | |||
| CHEMBL28626 | 2593 | None | 63 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -144 | 2 | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | Oc1ccc(c(c1)O)c1oc2cc(O)cc(c2c(=O)c1O)O | 10.1021/ml2003058 | |||
| 135399235 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml300076u | |||
| 2919 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml300076u | |||
| 5722 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml300076u | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml300076u | |||
| 12533774 | 185624 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 316 | 2 | 2 | 6 | 1.6 | Cc1c2oc(=O)c(C(=O)O)cc2cc2cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4862654 | 185624 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 316 | 2 | 2 | 6 | 1.6 | Cc1c2oc(=O)c(C(=O)O)cc2cc2cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 172455183 | 196373 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -2 | 2 | ChEMBL | 518 | 4 | 2 | 6 | 5.0 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CCCCC2)c1Cl)C(=O)OC1CCCCC1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5422437 | 196373 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -2 | 2 | ChEMBL | 518 | 4 | 2 | 6 | 5.0 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CCCCC2)c1Cl)C(=O)OC1CCCCC1 | 10.1016/j.bmc.2023.117511 | |||
| 172452315 | 196082 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -11 | 2 | ChEMBL | 320 | 2 | 4 | 4 | 0.8 | O=C(O)C(=O)Nc1cc(NC(=O)C(=O)O)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5416593 | 196082 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -11 | 2 | ChEMBL | 320 | 2 | 4 | 4 | 0.8 | O=C(O)C(=O)Nc1cc(NC(=O)C(=O)O)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2023.117511 | |||
| 53258793 | 68092 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 374 | 8 | 1 | 3 | 6.3 | CCCCCCCCc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| CHEMBL1914589 | 68092 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 374 | 8 | 1 | 3 | 6.3 | CCCCCCCCc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| 5281672 | 56570 | None | 72 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 318 | 1 | 6 | 8 | 1.7 | O=c1c(O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/ml2003058 | |||
| CHEMBL164 | 56570 | None | 72 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 318 | 1 | 6 | 8 | 1.7 | O=c1c(O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/ml2003058 | |||
| 70694439 | 75331 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 222 | 1 | 1 | 3 | 3.0 | C#Cc1csc2c(C)c(C(=O)O)sc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037460 | 75331 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 222 | 1 | 1 | 3 | 3.0 | C#Cc1csc2c(C)c(C(=O)O)sc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 154634337 | 185439 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1cccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4859764 | 185439 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1cccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| 135468531 | 90858 | None | 19 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 524 | 3 | ChEMBL | 342 | 3 | 2 | 4 | 3.4 | O=C1N/C(=N/c2ccccc2F)S/C1=C\c1ccc(C(=O)O)cc1 | 10.6019/CHEMBL5442687 | |||
| CHEMBL2392141 | 90858 | None | 19 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 524 | 3 | ChEMBL | 342 | 3 | 2 | 4 | 3.4 | O=C1N/C(=N/c2ccccc2F)S/C1=C\c1ccc(C(=O)O)cc1 | 10.6019/CHEMBL5442687 | |||
| 16103462 | 68091 | None | 17 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 276 | 1 | 1 | 3 | 3.7 | Cc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| CHEMBL1914588 | 68091 | None | 17 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 276 | 1 | 1 | 3 | 3.7 | Cc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| 12138434 | 68084 | None | 1 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 317 | 4 | 0 | 4 | 4.4 | CCCCc1ccc(C2(C)OC(=C(C#N)C#N)C(C#N)=C2C)cc1 | 10.1021/jm200999f | |||
| CHEMBL1914581 | 68084 | None | 1 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 317 | 4 | 0 | 4 | 4.4 | CCCCc1ccc(C2(C)OC(=C(C#N)C#N)C(C#N)=C2C)cc1 | 10.1021/jm200999f | |||
| 66561717 | 75327 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 356 | 1 | 2 | 4 | 3.9 | O=C(O)c1sc2c(Br)c(Br)sc2c1O | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037456 | 75327 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 356 | 1 | 2 | 4 | 3.9 | O=C(O)c1sc2c(Br)c(Br)sc2c1O | 10.1016/j.bmcl.2012.04.057 | |||
| 135399235 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm200999f | |||
| 2919 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm200999f | |||
| 5722 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm200999f | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm200999f | |||
| 135399235 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmcl.2012.04.057 | |||
| 2919 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmcl.2012.04.057 | |||
| 5722 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmcl.2012.04.057 | |||
| 70691268 | 77738 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 364 | 1 | 2 | 3 | 4.1 | Cc1c(C(=O)O)sc2cc(Br)c(O)c(Br)c12 | 10.1021/ml300076u | |||
| CHEMBL2089229 | 77738 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 364 | 1 | 2 | 3 | 4.1 | Cc1c(C(=O)O)sc2cc(Br)c(O)c(Br)c12 | 10.1021/ml300076u | |||
| 135399235 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml2003058 | |||
| 2919 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml2003058 | |||
| 5722 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml2003058 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml2003058 | |||
| 151577785 | 186659 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 312 | 3 | 2 | 5 | 2.9 | COc1cccc(-c2cc3cc(C(=O)O)c(=O)oc3cc2O)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4878047 | 186659 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 312 | 3 | 2 | 5 | 2.9 | COc1cccc(-c2cc3cc(C(=O)O)c(=O)oc3cc2O)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| 45093111 | 77735 | None | 7 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 208 | 1 | 3 | 4 | 1.9 | Cc1c(C(=O)O)oc2cc(O)c(O)cc12 | 10.1021/ml300076u | |||
| CHEMBL2089226 | 77735 | None | 7 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 208 | 1 | 3 | 4 | 1.9 | Cc1c(C(=O)O)oc2cc(O)c(O)cc12 | 10.1021/ml300076u | |||
| 154634333 | 185321 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 352 | 2 | 2 | 6 | 2.4 | O=C(O)c1cc2c3ccccc3c3cc(C(=O)O)c(=O)oc3c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4857772 | 185321 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 352 | 2 | 2 | 6 | 2.4 | O=C(O)c1cc2c3ccccc3c3cc(C(=O)O)c(=O)oc3c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 154634330 | 186058 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 396 | 3 | 2 | 6 | 3.1 | O=C(O)c1cc2c(oc1=O)c(-c1cccc(F)c1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4869539 | 186058 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 396 | 3 | 2 | 6 | 3.1 | O=C(O)c1cc2c(oc1=O)c(-c1cccc(F)c1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634321 | 186103 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2c3oc(=O)c(C(=O)O)cc3cc3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4870213 | 186103 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2c3oc(=O)c(C(=O)O)cc3cc3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 135468531 | 90858 | None | 19 | Mouse | Functional | pEC50 | = | 4.8 | 4.8 | -1122 | 3 | ChEMBL | 342 | 3 | 2 | 4 | 3.4 | O=C1N/C(=N/c2ccccc2F)S/C1=C\c1ccc(C(=O)O)cc1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL2392141 | 90858 | None | 19 | Mouse | Functional | pEC50 | = | 4.8 | 4.8 | -1122 | 3 | ChEMBL | 342 | 3 | 2 | 4 | 3.4 | O=C1N/C(=N/c2ccccc2F)S/C1=C\c1ccc(C(=O)O)cc1 | 10.1016/j.bmc.2023.117511 | |||
| 9990345 | 68087 | None | 32 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 199 | 0 | 0 | 4 | 1.9 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)C | 10.1021/jm200999f | |||
| CHEMBL1914584 | 68087 | None | 32 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 199 | 0 | 0 | 4 | 1.9 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)C | 10.1021/jm200999f | |||
| 70697499 | 77721 | None | 0 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 297 | 3 | 3 | 4 | 3.1 | Cc1ccc(Cn2c(C(=O)O)cc3cc(O)c(O)cc32)cc1 | 10.1021/ml300076u | |||
| CHEMBL2089195 | 77721 | None | 0 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 297 | 3 | 3 | 4 | 3.1 | Cc1ccc(Cn2c(C(=O)O)cc3cc(O)c(O)cc32)cc1 | 10.1021/ml300076u | |||
| 12897302 | 110480 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 20 | 2 | ChEMBL | 286 | 2 | 4 | 4 | 0.4 | O=C(O)C(=O)Nc1cccc(NC(=O)C(=O)O)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL3245042 | 110480 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 20 | 2 | ChEMBL | 286 | 2 | 4 | 4 | 0.4 | O=C(O)C(=O)Nc1cccc(NC(=O)C(=O)O)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 110720191 | 162552 | None | 1 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 295 | 4 | 2 | 5 | 2.1 | COc1ccc(C(=O)Nc2ccc(-c3nnn[nH]3)cc2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4166802 | 162552 | None | 1 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 295 | 4 | 2 | 5 | 2.1 | COc1ccc(C(=O)Nc2ccc(-c3nnn[nH]3)cc2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 70692386 | 75334 | None | 0 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 280 | 2 | 1 | 4 | 4.7 | Cc1c(C(=O)O)sc2c(-c3ccsc3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037463 | 75334 | None | 0 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 280 | 2 | 1 | 4 | 4.7 | Cc1c(C(=O)O)sc2c(-c3ccsc3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 16103462 | 68091 | None | 17 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 276 | 1 | 1 | 3 | 3.7 | Cc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/ml2003058 | |||
| CHEMBL1914588 | 68091 | None | 17 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 276 | 1 | 1 | 3 | 3.7 | Cc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/ml2003058 | |||
| 73157 | 197815 | None | 27 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 456 | 10 | 2 | 7 | 5.5 | CCCCCc1c2c(cc(O)c1C(=O)O)OC(=O)c1c(cc(OC)cc1C(=O)CCCC)O2 | 10.1021/ml2003058 | |||
| CHEMBL551842 | 197815 | None | 27 | Human | Functional | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 456 | 10 | 2 | 7 | 5.5 | CCCCCc1c2c(cc(O)c1C(=O)O)OC(=O)c1c(cc(OC)cc1C(=O)CCCC)O2 | 10.1021/ml2003058 | |||
| 154634326 | 185198 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 404 | 2 | 2 | 8 | 1.5 | O=C(O)c1cc2c(oc1=O)c(Br)cc1cc(-c3nnn[nH]3)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4856029 | 185198 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 404 | 2 | 2 | 8 | 1.5 | O=C(O)c1cc2c(oc1=O)c(Br)cc1cc(-c3nnn[nH]3)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 149708825 | 186497 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 300 | 2 | 2 | 4 | 3.0 | O=C(O)c1cc2cc(-c3ccccc3F)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4875771 | 186497 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 300 | 2 | 2 | 4 | 3.0 | O=C(O)c1cc2cc(-c3ccccc3F)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 53258795 | 68093 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 416 | 11 | 1 | 3 | 7.5 | CCCCCCCCCCCc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| CHEMBL1914590 | 68093 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 416 | 11 | 1 | 3 | 7.5 | CCCCCCCCCCCc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| 145959306 | 162409 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1cccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4164556 | 162409 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1cccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| 145949189 | 162832 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 313 | 4 | 2 | 5 | 2.3 | COc1ccc(C(=O)Nc2cc(F)ccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4171326 | 162832 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 313 | 4 | 2 | 5 | 2.3 | COc1ccc(C(=O)Nc2cc(F)ccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 2920 | 2997 | None | 64 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 2398 | 2 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acs.jmedchem.0c01624 | |||
| 54742459 | 2997 | None | 64 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 2398 | 2 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acs.jmedchem.0c01624 | |||
| 8546 | 2997 | None | 64 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 2398 | 2 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL177880 | 2997 | None | 64 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 2398 | 2 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acs.jmedchem.0c01624 | |||
| 154634332 | 185233 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4856506 | 185233 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 172458982 | 196417 | None | 0 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | 1 | 2 | ChEMBL | 442 | 7 | 2 | 8 | 2.2 | CCOC(=O)C(=O)Nc1cc(C(=O)OCC(C)C)cc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5423540 | 196417 | None | 0 | Mouse | Functional | pEC50 | = | 7.7 | 7.7 | 1 | 2 | ChEMBL | 442 | 7 | 2 | 8 | 2.2 | CCOC(=O)C(=O)Nc1cc(C(=O)OCC(C)C)cc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 145949189 | 162832 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 313 | 4 | 2 | 5 | 2.3 | COc1ccc(C(=O)Nc2cc(F)ccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4171326 | 162832 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 313 | 4 | 2 | 5 | 2.3 | COc1ccc(C(=O)Nc2cc(F)ccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 135399235 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acsmedchemlett.7b00510 | |||
| 2919 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acsmedchemlett.7b00510 | |||
| 5722 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acsmedchemlett.7b00510 | |||
| 135399235 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmc.2023.117511 | |||
| 2919 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmc.2023.117511 | |||
| 5722 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmc.2023.117511 | |||
| 70693381 | 77726 | None | 0 | Human | Functional | pEC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 269 | 2 | 4 | 3 | 2.9 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1ccccc1 | 10.1021/ml300076u | |||
| CHEMBL2089217 | 77726 | None | 0 | Human | Functional | pEC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 269 | 2 | 4 | 3 | 2.9 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1ccccc1 | 10.1021/ml300076u | |||
| 145958445 | 162225 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.2 | Cc1ccccc1C(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4161574 | 162225 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.2 | Cc1ccccc1C(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| 152243845 | 185005 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 324 | 3 | 2 | 4 | 4.0 | CC(C)c1ccc(-c2cc3cc(C(=O)O)c(=O)oc3cc2O)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4853043 | 185005 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 324 | 3 | 2 | 4 | 4.0 | CC(C)c1ccc(-c2cc3cc(C(=O)O)c(=O)oc3cc2O)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 145955278 | 162654 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccc(Cl)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4168406 | 162654 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccc(Cl)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| 152550147 | 185434 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 300 | 2 | 2 | 4 | 3.0 | O=C(O)c1cc2cc(-c3cccc(F)c3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4859675 | 185434 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 300 | 2 | 2 | 4 | 3.0 | O=C(O)c1cc2cc(-c3cccc(F)c3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 154634334 | 185531 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 396 | 3 | 2 | 6 | 3.1 | O=C(O)c1cc2c(oc1=O)c(-c1ccccc1F)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4861414 | 185531 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 396 | 3 | 2 | 6 | 3.1 | O=C(O)c1cc2c(oc1=O)c(-c1ccccc1F)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 70681838 | 75325 | None | 0 | Human | Functional | pEC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 290 | 1 | 1 | 3 | 4.0 | Cc1sc2c(C)c(C(=O)O)sc2c1Br | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037453 | 75325 | None | 0 | Human | Functional | pEC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 290 | 1 | 1 | 3 | 4.0 | Cc1sc2c(C)c(C(=O)O)sc2c1Br | 10.1016/j.bmcl.2012.04.057 | |||
| 70687102 | 77730 | None | 0 | Human | Functional | pEC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 313 | 3 | 5 | 4 | 2.6 | O=C(O)c1ccc(-c2c(C(=O)O)[nH]c3cc(O)c(O)cc23)cc1 | 10.1021/ml300076u | |||
| CHEMBL2089221 | 77730 | None | 0 | Human | Functional | pEC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 313 | 3 | 5 | 4 | 2.6 | O=C(O)c1ccc(-c2c(C(=O)O)[nH]c3cc(O)c(O)cc23)cc1 | 10.1021/ml300076u | |||
| 53258795 | 68093 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 416 | 11 | 1 | 3 | 7.5 | CCCCCCCCCCCc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| CHEMBL1914590 | 68093 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 416 | 11 | 1 | 3 | 7.5 | CCCCCCCCCCCc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| 5281605 | 208190 | None | 72 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 270 | 1 | 3 | 5 | 2.6 | O=c1cc(-c2ccccc2)oc2cc(O)c(O)c(O)c12 | 10.1021/ml2003058 | |||
| CHEMBL8260 | 208190 | None | 72 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 270 | 1 | 3 | 5 | 2.6 | O=c1cc(-c2ccccc2)oc2cc(O)c(O)c(O)c12 | 10.1021/ml2003058 | |||
| 53258796 | 68094 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 444 | 13 | 1 | 3 | 8.3 | CCCCCCCCCCCCCc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| CHEMBL1914591 | 68094 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 444 | 13 | 1 | 3 | 8.3 | CCCCCCCCCCCCCc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| 3715518 | 29766 | None | 5 | Human | Functional | pEC50 | = | 4.6 | 4.6 | -13 | 4 | ChEMBL | 379 | 9 | 1 | 3 | 5.2 | COc1ccc(CNCCC(c2ccc(F)cc2)c2ccc(OC)cc2)cc1 | nan | |||
| CHEMBL1386881 | 29766 | None | 5 | Human | Functional | pEC50 | = | 4.6 | 4.6 | -13 | 4 | ChEMBL | 379 | 9 | 1 | 3 | 5.2 | COc1ccc(CNCCC(c2ccc(F)cc2)c2ccc(OC)cc2)cc1 | nan | |||
| 119405 | 97197 | None | 48 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 193 | 1 | 4 | 3 | 1.3 | O=C(O)c1cc2cc(O)c(O)cc2[nH]1 | 10.1021/ml300076u | |||
| CHEMBL267855 | 97197 | None | 48 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 193 | 1 | 4 | 3 | 1.3 | O=C(O)c1cc2cc(O)c(O)cc2[nH]1 | 10.1021/ml300076u | |||
| 150386356 | 185252 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 312 | 3 | 2 | 5 | 2.9 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3cc2O)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4856916 | 185252 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 312 | 3 | 2 | 5 | 2.9 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3cc2O)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 119405 | 97197 | None | 48 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 193 | 1 | 4 | 3 | 1.3 | O=C(O)c1cc2cc(O)c(O)cc2[nH]1 | 10.1021/ml300076u | |||
| CHEMBL267855 | 97197 | None | 48 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 193 | 1 | 4 | 3 | 1.3 | O=C(O)c1cc2cc(O)c(O)cc2[nH]1 | 10.1021/ml300076u | |||
| CHEMBL4784835 | 216536 | None | 44 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | None | None | None | O=C([O-])c1cc2ccccc2c(Cc2c(O)c(C(=O)[O-])cc3ccccc23)c1O.[Na+].[Na+] | 10.6019/CHEMBL5442687 | |||||
| 73157 | 197815 | None | 27 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 456 | 10 | 2 | 7 | 5.5 | CCCCCc1c2c(cc(O)c1C(=O)O)OC(=O)c1c(cc(OC)cc1C(=O)CCCC)O2 | 10.1021/ml2003058 | |||
| CHEMBL551842 | 197815 | None | 27 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 456 | 10 | 2 | 7 | 5.5 | CCCCCc1c2c(cc(O)c1C(=O)O)OC(=O)c1c(cc(OC)cc1C(=O)CCCC)O2 | 10.1021/ml2003058 | |||
| 152684818 | 185098 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 312 | 3 | 2 | 5 | 2.9 | COc1ccccc1-c1cc2cc(C(=O)O)c(=O)oc2cc1O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4854346 | 185098 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 312 | 3 | 2 | 5 | 2.9 | COc1ccccc1-c1cc2cc(C(=O)O)c(=O)oc2cc1O | 10.1021/acs.jmedchem.0c01624 | |||
| 66561718 | 75333 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 275 | 2 | 1 | 4 | 4.0 | Cc1c(C(=O)O)sc2c(-c3cccnc3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037462 | 75333 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 275 | 2 | 1 | 4 | 4.0 | Cc1c(C(=O)O)sc2c(-c3cccnc3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 70687103 | 77731 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 337 | 2 | 4 | 3 | 4.3 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1cc(Cl)cc(Cl)c1 | 10.1021/ml300076u | |||
| CHEMBL2089222 | 77731 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 337 | 2 | 4 | 3 | 4.3 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1cc(Cl)cc(Cl)c1 | 10.1021/ml300076u | |||
| 66561717 | 75327 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 356 | 1 | 2 | 4 | 3.9 | O=C(O)c1sc2c(Br)c(Br)sc2c1O | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037456 | 75327 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 356 | 1 | 2 | 4 | 3.9 | O=C(O)c1sc2c(Br)c(Br)sc2c1O | 10.1016/j.bmcl.2012.04.057 | |||
| 70695483 | 77727 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 303 | 2 | 4 | 3 | 3.6 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1cccc(Cl)c1 | 10.1021/ml300076u | |||
| CHEMBL2089218 | 77727 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 303 | 2 | 4 | 3 | 3.6 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1cccc(Cl)c1 | 10.1021/ml300076u | |||
| 70689184 | 77729 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 313 | 3 | 5 | 4 | 2.6 | O=C(O)c1cccc(-c2c(C(=O)O)[nH]c3cc(O)c(O)cc23)c1 | 10.1021/ml300076u | |||
| CHEMBL2089220 | 77729 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 313 | 3 | 5 | 4 | 2.6 | O=C(O)c1cccc(-c2c(C(=O)O)[nH]c3cc(O)c(O)cc23)c1 | 10.1021/ml300076u | |||
| 154634327 | 184845 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 380 | 2 | 2 | 6 | 2.1 | O=C(O)c1cc2cc3cc(C(=O)O)c(=O)oc3c(Br)c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4850743 | 184845 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 380 | 2 | 2 | 6 | 2.1 | O=C(O)c1cc2cc3cc(C(=O)O)c(=O)oc3c(Br)c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 135468531 | 90858 | None | 19 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 524 | 3 | ChEMBL | 342 | 3 | 2 | 4 | 3.4 | O=C1N/C(=N/c2ccccc2F)S/C1=C\c1ccc(C(=O)O)cc1 | 10.6019/CHEMBL5442687 | |||
| CHEMBL2392141 | 90858 | None | 19 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 524 | 3 | ChEMBL | 342 | 3 | 2 | 4 | 3.4 | O=C1N/C(=N/c2ccccc2F)S/C1=C\c1ccc(C(=O)O)cc1 | 10.6019/CHEMBL5442687 | |||
| 172458982 | 196417 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -1 | 2 | ChEMBL | 442 | 7 | 2 | 8 | 2.2 | CCOC(=O)C(=O)Nc1cc(C(=O)OCC(C)C)cc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5423540 | 196417 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -1 | 2 | ChEMBL | 442 | 7 | 2 | 8 | 2.2 | CCOC(=O)C(=O)Nc1cc(C(=O)OCC(C)C)cc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 172465526 | 196714 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 364 | 2 | 4 | 4 | 1.1 | O=C(O)C(=O)Nc1cc(Br)cc(NC(=O)C(=O)O)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5430512 | 196714 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 364 | 2 | 4 | 4 | 1.1 | O=C(O)C(=O)Nc1cc(Br)cc(NC(=O)C(=O)O)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 154634326 | 185198 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 404 | 2 | 2 | 8 | 1.5 | O=C(O)c1cc2c(oc1=O)c(Br)cc1cc(-c3nnn[nH]3)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4856029 | 185198 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 404 | 2 | 2 | 8 | 1.5 | O=C(O)c1cc2c(oc1=O)c(Br)cc1cc(-c3nnn[nH]3)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 70691267 | 77733 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 303 | 2 | 4 | 3 | 3.6 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1ccc(Cl)cc1 | 10.1021/ml300076u | |||
| CHEMBL2089224 | 77733 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 303 | 2 | 4 | 3 | 3.6 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1ccc(Cl)cc1 | 10.1021/ml300076u | |||
| 944642 | 59137 | None | 8 | Human | Functional | pEC50 | = | 4.6 | 4.6 | -30 | 4 | ChEMBL | 324 | 5 | 2 | 4 | 4.2 | CCOc1ccc(-c2n[nH]c(C)c2-c2ccc(OC)cc2)c(O)c1 | nan | |||
| CHEMBL1698243 | 59137 | None | 8 | Human | Functional | pEC50 | = | 4.6 | 4.6 | -30 | 4 | ChEMBL | 324 | 5 | 2 | 4 | 4.2 | CCOc1ccc(-c2n[nH]c(C)c2-c2ccc(OC)cc2)c(O)c1 | nan | |||
| 135468531 | 90858 | None | 19 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 524 | 3 | ChEMBL | 342 | 3 | 2 | 4 | 3.4 | O=C1N/C(=N/c2ccccc2F)S/C1=C\c1ccc(C(=O)O)cc1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL2392141 | 90858 | None | 19 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 524 | 3 | ChEMBL | 342 | 3 | 2 | 4 | 3.4 | O=C1N/C(=N/c2ccccc2F)S/C1=C\c1ccc(C(=O)O)cc1 | 10.1016/j.bmc.2023.117511 | |||
| 70692386 | 75334 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 280 | 2 | 1 | 4 | 4.7 | Cc1c(C(=O)O)sc2c(-c3ccsc3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037463 | 75334 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 280 | 2 | 1 | 4 | 4.7 | Cc1c(C(=O)O)sc2c(-c3ccsc3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 40915 | 78306 | None | 17 | Mouse | Functional | pEC50 | = | 6.6 | 6.6 | -9 | 2 | ChEMBL | 367 | 4 | 2 | 7 | 1.2 | CCOC(=O)C(=O)Nc1cc(C#N)cc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL2107161 | 78306 | None | 17 | Mouse | Functional | pEC50 | = | 6.6 | 6.6 | -9 | 2 | ChEMBL | 367 | 4 | 2 | 7 | 1.2 | CCOC(=O)C(=O)Nc1cc(C#N)cc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 70690212 | 75330 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 302 | 2 | 1 | 3 | 4.3 | O=C(O)c1sc2c(Br)csc2c1C1CC1 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037459 | 75330 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 302 | 2 | 1 | 3 | 4.3 | O=C(O)c1sc2c(Br)csc2c1C1CC1 | 10.1016/j.bmcl.2012.04.057 | |||
| 66561793 | 75337 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 258 | 2 | 2 | 3 | 3.3 | Cc1c(C(=O)O)[nH]c2c(-c3cccnc3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037466 | 75337 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 258 | 2 | 2 | 3 | 3.3 | Cc1c(C(=O)O)[nH]c2c(-c3cccnc3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 172469929 | 197028 | None | 0 | Mouse | Functional | pEC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 382 | 2 | 2 | 6 | 1.6 | COC(=O)C(=O)Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5437161 | 197028 | None | 0 | Mouse | Functional | pEC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 382 | 2 | 2 | 6 | 1.6 | COC(=O)C(=O)Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 150149078 | 186450 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 282 | 2 | 2 | 4 | 2.9 | O=C(O)c1cc2cc(-c3ccccc3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4875041 | 186450 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 282 | 2 | 2 | 4 | 2.9 | O=C(O)c1cc2cc(-c3ccccc3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 172465526 | 196714 | None | 0 | Mouse | Functional | pEC50 | = | 7.6 | 7.6 | -1 | 2 | ChEMBL | 364 | 2 | 4 | 4 | 1.1 | O=C(O)C(=O)Nc1cc(Br)cc(NC(=O)C(=O)O)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5430512 | 196714 | None | 0 | Mouse | Functional | pEC50 | = | 7.6 | 7.6 | -1 | 2 | ChEMBL | 364 | 2 | 4 | 4 | 1.1 | O=C(O)C(=O)Nc1cc(Br)cc(NC(=O)C(=O)O)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 172448625 | 196009 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 1 | 2 | ChEMBL | 420 | 4 | 2 | 6 | 2.1 | CCOC(=O)C(=O)Nc1cc(Br)cc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5415083 | 196009 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 1 | 2 | ChEMBL | 420 | 4 | 2 | 6 | 2.1 | CCOC(=O)C(=O)Nc1cc(Br)cc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 3884 | 44512 | None | 53 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 242 | 2 | 1 | 3 | 3.2 | CC(C)=CCC1=C(O)C(=O)c2ccccc2C1=O | 10.1021/ml2003058 | |||
| CHEMBL15193 | 44512 | None | 53 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 242 | 2 | 1 | 3 | 3.2 | CC(C)=CCC1=C(O)C(=O)c2ccccc2C1=O | 10.1021/ml2003058 | |||
| 152727536 | 184593 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 288 | 2 | 2 | 5 | 2.9 | O=C(O)c1cc2cc(-c3cccs3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4847144 | 184593 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 288 | 2 | 2 | 5 | 2.9 | O=C(O)c1cc2cc(-c3cccs3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 40915 | 78306 | None | 17 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 9 | 2 | ChEMBL | 367 | 4 | 2 | 7 | 1.2 | CCOC(=O)C(=O)Nc1cc(C#N)cc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL2107161 | 78306 | None | 17 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 9 | 2 | ChEMBL | 367 | 4 | 2 | 7 | 1.2 | CCOC(=O)C(=O)Nc1cc(C#N)cc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 154634322 | 185486 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 307 | 1 | 1 | 8 | 1.0 | N#Cc1cc2c(ccc3cc(-c4nnn[nH]4)c(=O)oc32)oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4860550 | 185486 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 307 | 1 | 1 | 8 | 1.0 | N#Cc1cc2c(ccc3cc(-c4nnn[nH]4)c(=O)oc32)oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 5281855 | 205301 | None | 65 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 302 | 0 | 4 | 8 | 1.3 | O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23 | 10.1021/ml2003058 | |||
| CHEMBL6246 | 205301 | None | 65 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 302 | 0 | 4 | 8 | 1.3 | O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23 | 10.1021/ml2003058 | |||
| 57134579 | 162727 | None | 21 | Human | Functional | pEC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 239 | 1 | 2 | 4 | 1.2 | Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4169520 | 162727 | None | 21 | Human | Functional | pEC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 239 | 1 | 2 | 4 | 1.2 | Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| 2920 | 2997 | None | 64 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 2398 | 2 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| 54742459 | 2997 | None | 64 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 2398 | 2 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| 8546 | 2997 | None | 64 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 2398 | 2 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL177880 | 2997 | None | 64 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 2398 | 2 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| 145957901 | 162169 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2ccc(Br)cc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4160729 | 162169 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2ccc(Br)cc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 145957901 | 162169 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2ccc(Br)cc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4160729 | 162169 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2ccc(Br)cc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 5281672 | 56570 | None | 72 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 318 | 1 | 6 | 8 | 1.7 | O=c1c(O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/ml2003058 | |||
| CHEMBL164 | 56570 | None | 72 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 318 | 1 | 6 | 8 | 1.7 | O=c1c(O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/ml2003058 | |||
| 172469929 | 197028 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -1 | 2 | ChEMBL | 382 | 2 | 2 | 6 | 1.6 | COC(=O)C(=O)Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5437161 | 197028 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -1 | 2 | ChEMBL | 382 | 2 | 2 | 6 | 1.6 | COC(=O)C(=O)Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 145951357 | 162859 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 411 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(Cl)cc1Cl | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4171772 | 162859 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 411 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(Cl)cc1Cl | 10.1021/acsmedchemlett.7b00510 | |||
| 154634320 | 186716 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 302 | 2 | 2 | 6 | 1.3 | O=C(O)c1cc2c(ccc3cc(C(=O)O)c(=O)oc32)oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4879017 | 186716 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 302 | 2 | 2 | 6 | 1.3 | O=C(O)c1cc2c(ccc3cc(C(=O)O)c(=O)oc32)oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 172454119 | 195785 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -33 | 2 | ChEMBL | 307 | 3 | 4 | 6 | -0.4 | COc1c(NC(=O)C(=O)O)cc(C#N)cc1NC(=O)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5410743 | 195785 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -33 | 2 | ChEMBL | 307 | 3 | 4 | 6 | -0.4 | COc1c(NC(=O)C(=O)O)cc(C#N)cc1NC(=O)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| 70683937 | 75067 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 408 | 1 | 1 | 3 | 5.2 | O=C(O)c1sc2c(Br)c(Br)sc2c1C(F)(F)F | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2035007 | 75067 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 408 | 1 | 1 | 3 | 5.2 | O=C(O)c1sc2c(Br)c(Br)sc2c1C(F)(F)F | 10.1016/j.bmcl.2012.04.057 | |||
| 145951357 | 162859 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 411 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(Cl)cc1Cl | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4171772 | 162859 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 411 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(Cl)cc1Cl | 10.1021/acsmedchemlett.7b00510 | |||
| 12138435 | 68079 | None | 26 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 329 | 1 | 0 | 4 | 4.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1 | 10.1021/jm200999f | |||
| CHEMBL1914576 | 68079 | None | 26 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 329 | 1 | 0 | 4 | 4.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1 | 10.1021/jm200999f | |||
| 5215 | 2386 | None | 74 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -1 | 4 | ChEMBL | 286 | 1 | 4 | 6 | 2.3 | Oc1cc(O)c2c(c1)oc(cc2=O)c1ccc(c(c1)O)O | 10.1021/ml2003058 | |||
| 5280445 | 2386 | None | 74 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -1 | 4 | ChEMBL | 286 | 1 | 4 | 6 | 2.3 | Oc1cc(O)c2c(c1)oc(cc2=O)c1ccc(c(c1)O)O | 10.1021/ml2003058 | |||
| CHEMBL151 | 2386 | None | 74 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -1 | 4 | ChEMBL | 286 | 1 | 4 | 6 | 2.3 | Oc1cc(O)c2c(c1)oc(cc2=O)c1ccc(c(c1)O)O | 10.1021/ml2003058 | |||
| 12897301 | 110477 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -40 | 2 | ChEMBL | 342 | 4 | 2 | 6 | 1.3 | CCOC(=O)C(=O)Nc1cccc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL3245010 | 110477 | None | 0 | Mouse | Functional | pEC50 | = | 5.5 | 5.5 | -40 | 2 | ChEMBL | 342 | 4 | 2 | 6 | 1.3 | CCOC(=O)C(=O)Nc1cccc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 154634315 | 184984 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 396 | 3 | 2 | 6 | 3.1 | O=C(O)c1cc2c(oc1=O)c(-c1ccc(F)cc1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4852718 | 184984 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 396 | 3 | 2 | 6 | 3.1 | O=C(O)c1cc2c(oc1=O)c(-c1ccc(F)cc1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 56646802 | 68080 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 351 | 1 | 0 | 4 | 3.8 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1c(F)c(F)c(F)c(F)c1F | 10.1021/jm200999f | |||
| CHEMBL1914577 | 68080 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 351 | 1 | 0 | 4 | 3.8 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1c(F)c(F)c(F)c(F)c1F | 10.1021/jm200999f | |||
| 135399235 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.0c01624 | |||
| 2919 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.0c01624 | |||
| 5722 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.0c01624 | |||
| 16103482 | 68088 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 268 | 6 | 1 | 3 | 4.8 | CCCCCCc1c(C(=O)O)sc2ccsc12 | 10.1021/jm200999f | |||
| CHEMBL1914585 | 68088 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 268 | 6 | 1 | 3 | 4.8 | CCCCCCc1c(C(=O)O)sc2ccsc12 | 10.1021/jm200999f | |||
| 70695483 | 77727 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 303 | 2 | 4 | 3 | 3.6 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1cccc(Cl)c1 | 10.1021/ml300076u | |||
| CHEMBL2089218 | 77727 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 303 | 2 | 4 | 3 | 3.6 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1cccc(Cl)c1 | 10.1021/ml300076u | |||
| 145971743 | 163199 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 361 | 3 | 2 | 4 | 3.0 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccccc1F | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4177096 | 163199 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 361 | 3 | 2 | 4 | 3.0 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccccc1F | 10.1021/acsmedchemlett.7b00510 | |||
| 145971743 | 163199 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 361 | 3 | 2 | 4 | 3.0 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccccc1F | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4177096 | 163199 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 361 | 3 | 2 | 4 | 3.0 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccccc1F | 10.1021/acsmedchemlett.7b00510 | |||
| 11674067 | 68081 | None | 27 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 315 | 1 | 0 | 4 | 3.6 | CC1=C(C#N)C(=C(C#N)C#N)OC1(c1ccccc1)C(F)(F)F | 10.1021/jm200999f | |||
| CHEMBL1914578 | 68081 | None | 27 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 315 | 1 | 0 | 4 | 3.6 | CC1=C(C#N)C(=C(C#N)C#N)OC1(c1ccccc1)C(F)(F)F | 10.1021/jm200999f | |||
| 12897302 | 110480 | None | 0 | Mouse | Functional | pEC50 | = | 5.4 | 5.4 | -20 | 2 | ChEMBL | 286 | 2 | 4 | 4 | 0.4 | O=C(O)C(=O)Nc1cccc(NC(=O)C(=O)O)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL3245042 | 110480 | None | 0 | Mouse | Functional | pEC50 | = | 5.4 | 5.4 | -20 | 2 | ChEMBL | 286 | 2 | 4 | 4 | 0.4 | O=C(O)C(=O)Nc1cccc(NC(=O)C(=O)O)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 145953959 | 162772 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 411 | 3 | 2 | 4 | 3.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(C(F)(F)F)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4170205 | 162772 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 411 | 3 | 2 | 4 | 3.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(C(F)(F)F)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 70686064 | 75326 | None | 0 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 354 | 1 | 1 | 3 | 4.5 | Cc1c(C(=O)O)sc2c(Br)c(Br)sc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037454 | 75326 | None | 0 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 354 | 1 | 1 | 3 | 4.5 | Cc1c(C(=O)O)sc2c(Br)c(Br)sc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 154634324 | 185817 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 384 | 3 | 2 | 7 | 3.0 | O=C(O)c1cc2c(oc1=O)c(-c1cccs1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4865638 | 185817 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 384 | 3 | 2 | 7 | 3.0 | O=C(O)c1cc2c(oc1=O)c(-c1cccs1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 70686065 | 75335 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 264 | 2 | 2 | 4 | 3.4 | Cc1c(C(=O)O)sc2c(-c3cn[nH]c3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037464 | 75335 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 264 | 2 | 2 | 4 | 3.4 | Cc1c(C(=O)O)sc2c(-c3cn[nH]c3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 12897304 | 110481 | None | 2 | Mouse | Functional | pEC50 | = | 6.4 | 6.4 | 11 | 2 | ChEMBL | 277 | 2 | 4 | 5 | -0.4 | N#Cc1cc(NC(=O)C(=O)O)cc(NC(=O)C(=O)O)c1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL3245047 | 110481 | None | 2 | Mouse | Functional | pEC50 | = | 6.4 | 6.4 | 11 | 2 | ChEMBL | 277 | 2 | 4 | 5 | -0.4 | N#Cc1cc(NC(=O)C(=O)O)cc(NC(=O)C(=O)O)c1 | 10.1016/j.bmc.2023.117511 | |||
| 145971240 | 163182 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 309 | 3 | 2 | 4 | 2.2 | CC(C)C(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4176719 | 163182 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 309 | 3 | 2 | 4 | 2.2 | CC(C)C(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| 145971240 | 163182 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 309 | 3 | 2 | 4 | 2.2 | CC(C)C(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4176719 | 163182 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 309 | 3 | 2 | 4 | 2.2 | CC(C)C(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| 5491415 | 75318 | None | 18 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 537 | 6 | 8 | 10 | 1.7 | CC(=O)NCCc1ccc(O)c(-c2c(O)c(O)c3c(c2O)C(=O)c2c(cc(O)c(C(=O)O)c2C(=O)O)C3=O)c1 | 10.1021/ml2003058 | |||
| CHEMBL2037378 | 75318 | None | 18 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 537 | 6 | 8 | 10 | 1.7 | CC(=O)NCCc1ccc(O)c(-c2c(O)c(O)c3c(c2O)C(=O)c2c(cc(O)c(C(=O)O)c2C(=O)O)C3=O)c1 | 10.1021/ml2003058 | |||
| 154634318 | 186105 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 318 | 2 | 3 | 7 | 1.0 | O=C(O)c1cc2cc3cc(C(=O)O)c(=O)oc3c(O)c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4870255 | 186105 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 318 | 2 | 3 | 7 | 1.0 | O=C(O)c1cc2cc3cc(C(=O)O)c(=O)oc3c(O)c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 70696510 | 75329 | None | 0 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 296 | 1 | 1 | 3 | 4.1 | O=C(O)c1sc2c(Br)csc2c1Cl | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037458 | 75329 | None | 0 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 296 | 1 | 1 | 3 | 4.1 | O=C(O)c1sc2c(Br)csc2c1Cl | 10.1016/j.bmcl.2012.04.057 | |||
| 2918 | 2204 | None | 75 | Human | Functional | pEC50 | = | 4.4 | 4.4 | -2630 | 4 | ChEMBL | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 10.1021/jm4009373 | |||
| 3845 | 2204 | None | 75 | Human | Functional | pEC50 | = | 4.4 | 4.4 | -2630 | 4 | ChEMBL | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 10.1021/jm4009373 | |||
| CHEMBL299155 | 2204 | None | 75 | Human | Functional | pEC50 | = | 4.4 | 4.4 | -2630 | 4 | ChEMBL | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 10.1021/jm4009373 | |||
| DB11937 | 2204 | None | 75 | Human | Functional | pEC50 | = | 4.4 | 4.4 | -2630 | 4 | ChEMBL | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 10.1021/jm4009373 | |||
| 70691265 | 77723 | None | 0 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 325 | 4 | 3 | 5 | 2.9 | Cc1ccc(C(=O)Cn2c(C(=O)O)cc3cc(O)c(O)cc32)cc1 | 10.1021/ml300076u | |||
| CHEMBL2089197 | 77723 | None | 0 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 325 | 4 | 3 | 5 | 2.9 | Cc1ccc(C(=O)Cn2c(C(=O)O)cc3cc(O)c(O)cc32)cc1 | 10.1021/ml300076u | |||
| 4488 | 205479 | None | 66 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | 10.1021/ml2003058 | |||
| CHEMBL63323 | 205479 | None | 66 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | 10.1021/ml2003058 | |||
| 145956623 | 162107 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 391 | 4 | 2 | 5 | 3.0 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)c(F)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4159575 | 162107 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 391 | 4 | 2 | 5 | 3.0 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)c(F)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| 3325 | 2338 | None | 44 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 12 | 2 | ChEMBL | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 10.1016/j.bmc.2023.117511 | |||
| 44564 | 2338 | None | 44 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 12 | 2 | ChEMBL | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 10.1016/j.bmc.2023.117511 | |||
| 9743 | 2338 | None | 44 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 12 | 2 | ChEMBL | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL1201266 | 2338 | None | 44 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 12 | 2 | ChEMBL | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 10.1016/j.bmc.2023.117511 | |||
| DB06794 | 2338 | None | 44 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 12 | 2 | ChEMBL | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 10.1016/j.bmc.2023.117511 | |||
| 145956623 | 162107 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 391 | 4 | 2 | 5 | 3.0 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)c(F)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4159575 | 162107 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 391 | 4 | 2 | 5 | 3.0 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)c(F)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| 12897322 | 110482 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 1 | 2 | ChEMBL | 300 | 2 | 4 | 4 | 0.7 | Cc1cc(NC(=O)C(=O)O)c(Cl)c(NC(=O)C(=O)O)c1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL3245049 | 110482 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 1 | 2 | ChEMBL | 300 | 2 | 4 | 4 | 0.7 | Cc1cc(NC(=O)C(=O)O)c(Cl)c(NC(=O)C(=O)O)c1 | 10.1016/j.bmc.2023.117511 | |||
| 70682865 | 77724 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 271 | 1 | 4 | 3 | 2.0 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1Br | 10.1021/ml300076u | |||
| CHEMBL2089199 | 77724 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 271 | 1 | 4 | 3 | 2.0 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1Br | 10.1021/ml300076u | |||
| 172448625 | 196009 | None | 0 | Mouse | Functional | pEC50 | = | 7.4 | 7.4 | -1 | 2 | ChEMBL | 420 | 4 | 2 | 6 | 2.1 | CCOC(=O)C(=O)Nc1cc(Br)cc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5415083 | 196009 | None | 0 | Mouse | Functional | pEC50 | = | 7.4 | 7.4 | -1 | 2 | ChEMBL | 420 | 4 | 2 | 6 | 2.1 | CCOC(=O)C(=O)Nc1cc(Br)cc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 135399235 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm200999f | |||
| 2919 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm200999f | |||
| 5722 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm200999f | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm200999f | |||
| 3325 | 2338 | None | 44 | Mouse | Functional | pEC50 | = | 6.4 | 6.4 | -12 | 2 | ChEMBL | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 10.1016/j.bmc.2023.117511 | |||
| 44564 | 2338 | None | 44 | Mouse | Functional | pEC50 | = | 6.4 | 6.4 | -12 | 2 | ChEMBL | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 10.1016/j.bmc.2023.117511 | |||
| 9743 | 2338 | None | 44 | Mouse | Functional | pEC50 | = | 6.4 | 6.4 | -12 | 2 | ChEMBL | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL1201266 | 2338 | None | 44 | Mouse | Functional | pEC50 | = | 6.4 | 6.4 | -12 | 2 | ChEMBL | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 10.1016/j.bmc.2023.117511 | |||
| DB06794 | 2338 | None | 44 | Mouse | Functional | pEC50 | = | 6.4 | 6.4 | -12 | 2 | ChEMBL | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 10.1016/j.bmc.2023.117511 | |||
| 660319 | 11007 | None | 59 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 184 | 1 | 1 | 3 | 2.7 | O=C(O)c1cc2sccc2s1 | 10.1021/jm200999f | |||
| CHEMBL1173787 | 11007 | None | 59 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 184 | 1 | 1 | 3 | 2.7 | O=C(O)c1cc2sccc2s1 | 10.1021/jm200999f | |||
| 12126688 | 110479 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | 1 | 2 | ChEMBL | 252 | 2 | 4 | 4 | -0.3 | O=C(O)C(=O)Nc1cccc(NC(=O)C(=O)O)c1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL3245041 | 110479 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | 1 | 2 | ChEMBL | 252 | 2 | 4 | 4 | -0.3 | O=C(O)C(=O)Nc1cccc(NC(=O)C(=O)O)c1 | 10.1016/j.bmc.2023.117511 | |||
| 68324914 | 185837 | None | 34 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 284 | 2 | 2 | 5 | 3.6 | O=C(O)c1cc2sc3cc(C(=O)O)sc3c2s1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4865971 | 185837 | None | 34 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 284 | 2 | 2 | 5 | 3.6 | O=C(O)c1cc2sc3cc(C(=O)O)sc3c2s1 | 10.1021/acs.jmedchem.0c01624 | |||
| 13950957 | 157420 | None | 8 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 284 | 1 | 2 | 4 | 2.0 | O=C(O)c1cc2cc(Br)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4077503 | 157420 | None | 8 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 284 | 1 | 2 | 4 | 2.0 | O=C(O)c1cc2cc(Br)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 15774808 | 77720 | None | 0 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 283 | 3 | 3 | 4 | 2.8 | O=C(O)c1cc2cc(O)c(O)cc2n1Cc1ccccc1 | 10.1021/ml300076u | |||
| CHEMBL2089194 | 77720 | None | 0 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 283 | 3 | 3 | 4 | 2.8 | O=C(O)c1cc2cc(O)c(O)cc2n1Cc1ccccc1 | 10.1021/ml300076u | |||
| 145958495 | 162292 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 349 | 3 | 2 | 4 | 3.1 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)C1CCCCC1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4162653 | 162292 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 349 | 3 | 2 | 4 | 3.1 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)C1CCCCC1 | 10.1021/acsmedchemlett.7b00510 | |||
| 70687104 | 77732 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 305 | 2 | 4 | 3 | 3.2 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1cc(F)cc(F)c1 | 10.1021/ml300076u | |||
| CHEMBL2089223 | 77732 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 305 | 2 | 4 | 3 | 3.2 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1cc(F)cc(F)c1 | 10.1021/ml300076u | |||
| 70689180 | 77722 | None | 0 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 311 | 4 | 3 | 5 | 2.6 | O=C(Cn1c(C(=O)O)cc2cc(O)c(O)cc21)c1ccccc1 | 10.1021/ml300076u | |||
| CHEMBL2089196 | 77722 | None | 0 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 311 | 4 | 3 | 5 | 2.6 | O=C(Cn1c(C(=O)O)cc2cc(O)c(O)cc21)c1ccccc1 | 10.1021/ml300076u | |||
| 145958495 | 162292 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 349 | 3 | 2 | 4 | 3.1 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)C1CCCCC1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4162653 | 162292 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 349 | 3 | 2 | 4 | 3.1 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)C1CCCCC1 | 10.1021/acsmedchemlett.7b00510 | |||
| 10868388 | 162227 | None | 37 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 239 | 1 | 2 | 4 | 1.2 | Nc1ccc(Br)cc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4161599 | 162227 | None | 37 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 239 | 1 | 2 | 4 | 1.2 | Nc1ccc(Br)cc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| 1599 | 2341 | None | 28 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -239 | 32 | ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.6019/CHEMBL5442687 | |||
| 3955 | 2341 | None | 28 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -239 | 32 | ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.6019/CHEMBL5442687 | |||
| 3955.0 | 2341 | None | 28 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -239 | 32 | ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.6019/CHEMBL5442687 | |||
| 7215 | 2341 | None | 28 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -239 | 32 | ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.6019/CHEMBL5442687 | |||
| CHEMBL841 | 2341 | None | 28 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -239 | 32 | ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.6019/CHEMBL5442687 | |||
| DB00836 | 2341 | None | 28 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -239 | 32 | ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.6019/CHEMBL5442687 | |||
| 145954149 | 162694 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 361 | 3 | 2 | 4 | 3.0 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(F)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4169062 | 162694 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 361 | 3 | 2 | 4 | 3.0 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(F)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 12897304 | 110481 | None | 2 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -11 | 2 | ChEMBL | 277 | 2 | 4 | 5 | -0.4 | N#Cc1cc(NC(=O)C(=O)O)cc(NC(=O)C(=O)O)c1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL3245047 | 110481 | None | 2 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -11 | 2 | ChEMBL | 277 | 2 | 4 | 5 | -0.4 | N#Cc1cc(NC(=O)C(=O)O)cc(NC(=O)C(=O)O)c1 | 10.1016/j.bmc.2023.117511 | |||
| 154634323 | 184710 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 380 | 2 | 2 | 6 | 2.1 | O=C(O)c1cc2c(oc1=O)c(Br)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4848949 | 184710 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 380 | 2 | 2 | 6 | 2.1 | O=C(O)c1cc2c(oc1=O)c(Br)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 145954149 | 162694 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 361 | 3 | 2 | 4 | 3.0 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(F)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4169062 | 162694 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 361 | 3 | 2 | 4 | 3.0 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(F)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 15774807 | 77718 | None | 24 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 207 | 1 | 3 | 4 | 1.3 | Cn1c(C(=O)O)cc2cc(O)c(O)cc21 | 10.1021/ml300076u | |||
| CHEMBL2089192 | 77718 | None | 24 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 207 | 1 | 3 | 4 | 1.3 | Cn1c(C(=O)O)cc2cc(O)c(O)cc21 | 10.1021/ml300076u | |||
| 53258898 | 68095 | None | 0 | Human | Functional | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 472 | 15 | 1 | 3 | 9.1 | CCCCCCCCCCCCCCCc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| CHEMBL1914592 | 68095 | None | 0 | Human | Functional | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 472 | 15 | 1 | 3 | 9.1 | CCCCCCCCCCCCCCCc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| 70697498 | 77719 | None | 0 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 221 | 2 | 3 | 4 | 1.8 | CCn1c(C(=O)O)cc2cc(O)c(O)cc21 | 10.1021/ml300076u | |||
| CHEMBL2089193 | 77719 | None | 0 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 221 | 2 | 3 | 4 | 1.8 | CCn1c(C(=O)O)cc2cc(O)c(O)cc21 | 10.1021/ml300076u | |||
| 21337669 | 68085 | None | 0 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 239 | 0 | 0 | 4 | 2.9 | CC1=C(C#N)C(=C(C#N)C#N)OC12CCCCC2 | 10.1021/jm200999f | |||
| CHEMBL1914582 | 68085 | None | 0 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 239 | 0 | 0 | 4 | 2.9 | CC1=C(C#N)C(=C(C#N)C#N)OC12CCCCC2 | 10.1021/jm200999f | |||
| 145952561 | 163054 | None | 0 | Human | Functional | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 411 | 3 | 2 | 4 | 3.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccc(C(F)(F)F)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4174783 | 163054 | None | 0 | Human | Functional | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 411 | 3 | 2 | 4 | 3.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccc(C(F)(F)F)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| 70691268 | 77738 | None | 0 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 364 | 1 | 2 | 3 | 4.1 | Cc1c(C(=O)O)sc2cc(Br)c(O)c(Br)c12 | 10.1021/ml300076u | |||
| CHEMBL2089229 | 77738 | None | 0 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 364 | 1 | 2 | 3 | 4.1 | Cc1c(C(=O)O)sc2cc(Br)c(O)c(Br)c12 | 10.1021/ml300076u | |||
| 135403802 | 26539 | None | 39 | Human | Functional | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 300 | 0 | 4 | 6 | 1.3 | O=C1C=C2CC3(O)COc4c(ccc(O)c4O)C3=C2C=C1O | 10.1021/ml2003058 | |||
| CHEMBL1360563 | 26539 | None | 39 | Human | Functional | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 300 | 0 | 4 | 6 | 1.3 | O=C1C=C2CC3(O)COc4c(ccc(O)c4O)C3=C2C=C1O | 10.1021/ml2003058 | |||
| 3884 | 44512 | None | 53 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 242 | 2 | 1 | 3 | 3.2 | CC(C)=CCC1=C(O)C(=O)c2ccccc2C1=O | 10.1021/ml2003058 | |||
| CHEMBL15193 | 44512 | None | 53 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 242 | 2 | 1 | 3 | 3.2 | CC(C)=CCC1=C(O)C(=O)c2ccccc2C1=O | 10.1021/ml2003058 | |||
| 154634328 | 185207 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 378 | 3 | 2 | 6 | 3.0 | O=C(O)c1cc2c(oc1=O)c(-c1ccccc1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4856069 | 185207 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 378 | 3 | 2 | 6 | 3.0 | O=C(O)c1cc2c(oc1=O)c(-c1ccccc1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 164627011 | 186512 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 350 | 2 | 2 | 4 | 3.8 | Cc1c2nc(C(=O)O)cc(Cl)c2cc2c(Cl)cc(C(=O)O)nc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4876009 | 186512 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 350 | 2 | 2 | 4 | 3.8 | Cc1c2nc(C(=O)O)cc(Cl)c2cc2c(Cl)cc(C(=O)O)nc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 2920 | 2997 | None | 64 | Human | Functional | pEC50 | = | 6.3 | 6.3 | 2398 | 2 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acs.jmedchem.0c01624 | |||
| 54742459 | 2997 | None | 64 | Human | Functional | pEC50 | = | 6.3 | 6.3 | 2398 | 2 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acs.jmedchem.0c01624 | |||
| 8546 | 2997 | None | 64 | Human | Functional | pEC50 | = | 6.3 | 6.3 | 2398 | 2 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL177880 | 2997 | None | 64 | Human | Functional | pEC50 | = | 6.3 | 6.3 | 2398 | 2 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acs.jmedchem.0c01624 | |||
| 6619478 | 25945 | None | 1 | Human | Functional | pEC50 | = | 6.3 | 6.3 | -9 | 2 | ChEMBL | 501 | 4 | 2 | 8 | 4.5 | COc1ccc(NC(=O)c2cnn3c(O)cc(C4CCN(C(=O)OC(C)(C)C)CC4)nc23)cc1Cl | nan | |||
| CHEMBL1354041 | 25945 | None | 1 | Human | Functional | pEC50 | = | 6.3 | 6.3 | -9 | 2 | ChEMBL | 501 | 4 | 2 | 8 | 4.5 | COc1ccc(NC(=O)c2cnn3c(O)cc(C4CCN(C(=O)OC(C)(C)C)CC4)nc23)cc1Cl | nan | |||
| 70683937 | 75067 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 408 | 1 | 1 | 3 | 5.2 | O=C(O)c1sc2c(Br)c(Br)sc2c1C(F)(F)F | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2035007 | 75067 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 408 | 1 | 1 | 3 | 5.2 | O=C(O)c1sc2c(Br)c(Br)sc2c1C(F)(F)F | 10.1016/j.bmcl.2012.04.057 | |||
| 145955027 | 162635 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 349 | 3 | 2 | 5 | 2.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccs1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4168042 | 162635 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 349 | 3 | 2 | 5 | 2.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccs1 | 10.1021/acsmedchemlett.7b00510 | |||
| 145955027 | 162635 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 349 | 3 | 2 | 5 | 2.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccs1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4168042 | 162635 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 349 | 3 | 2 | 5 | 2.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccs1 | 10.1021/acsmedchemlett.7b00510 | |||
| 5491415 | 75318 | None | 18 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 537 | 6 | 8 | 10 | 1.7 | CC(=O)NCCc1ccc(O)c(-c2c(O)c(O)c3c(c2O)C(=O)c2c(cc(O)c(C(=O)O)c2C(=O)O)C3=O)c1 | 10.1021/ml2003058 | |||
| CHEMBL2037378 | 75318 | None | 18 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 537 | 6 | 8 | 10 | 1.7 | CC(=O)NCCc1ccc(O)c(-c2c(O)c(O)c3c(c2O)C(=O)c2c(cc(O)c(C(=O)O)c2C(=O)O)C3=O)c1 | 10.1021/ml2003058 | |||
| 44351698 | 120912 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 464 | 8 | 3 | 7 | 3.2 | O=C(O)c1cc(=O)c2c(CCC(O)CCc3cccc4oc(C(=O)O)cc(=O)c34)cccc2o1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL3558475 | 120912 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 464 | 8 | 3 | 7 | 3.2 | O=C(O)c1cc(=O)c2c(CCC(O)CCc3cccc4oc(C(=O)O)cc(=O)c34)cccc2o1 | 10.1021/acs.jmedchem.0c01624 | |||
| 145958540 | 162364 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(Cl)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4163894 | 162364 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(Cl)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 6622007 | 39053 | None | 4 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -9 | 4 | ChEMBL | 489 | 3 | 2 | 7 | 4.6 | CC(C)(C)OC(=O)N1CCC(c2cc(O)n3ncc(C(=O)Nc4ccc(F)c(Cl)c4)c3n2)CC1 | nan | |||
| CHEMBL1468612 | 39053 | None | 4 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -9 | 4 | ChEMBL | 489 | 3 | 2 | 7 | 4.6 | CC(C)(C)OC(=O)N1CCC(c2cc(O)n3ncc(C(=O)Nc4ccc(F)c(Cl)c4)c3n2)CC1 | nan | |||
| 145958540 | 162364 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(Cl)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4163894 | 162364 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(Cl)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 70683939 | 75332 | None | 0 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 238 | 2 | 1 | 3 | 3.8 | Cc1c(C(=O)O)sc2c(C3CC3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037461 | 75332 | None | 0 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 238 | 2 | 1 | 3 | 3.8 | Cc1c(C(=O)O)sc2c(C3CC3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 70686065 | 75335 | None | 0 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 264 | 2 | 2 | 4 | 3.4 | Cc1c(C(=O)O)sc2c(-c3cn[nH]c3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037464 | 75335 | None | 0 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 264 | 2 | 2 | 4 | 3.4 | Cc1c(C(=O)O)sc2c(-c3cn[nH]c3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 70690213 | 75339 | None | 0 | Human | Functional | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 273 | 1 | 1 | 3 | 3.0 | Cc1c(C(=O)O)n(C)c2c(Br)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037468 | 75339 | None | 0 | Human | Functional | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 273 | 1 | 1 | 3 | 3.0 | Cc1c(C(=O)O)n(C)c2c(Br)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 135399235 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml300076u | |||
| 2919 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml300076u | |||
| 5722 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml300076u | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml300076u | |||
| 12897316 | 196999 | None | 0 | Mouse | Functional | pEC50 | = | 5.3 | 5.3 | -41 | 2 | ChEMBL | 330 | 3 | 5 | 5 | 0.1 | O=C(O)C(=O)Nc1cc(C(=O)O)cc(NC(=O)C(=O)O)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5436420 | 196999 | None | 0 | Mouse | Functional | pEC50 | = | 5.3 | 5.3 | -41 | 2 | ChEMBL | 330 | 3 | 5 | 5 | 0.1 | O=C(O)C(=O)Nc1cc(C(=O)O)cc(NC(=O)C(=O)O)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 21337671 | 68086 | None | 0 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 297 | 1 | 0 | 4 | 3.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(F)cc1F | 10.1021/jm200999f | |||
| CHEMBL1914583 | 68086 | None | 0 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 297 | 1 | 0 | 4 | 3.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(F)cc1F | 10.1021/jm200999f | |||
| 153273978 | 198382 | None | 6 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 248 | 1 | 4 | 5 | 1.0 | O=C(O)c1cc(O)c(=O)c2c(O)c(O)ccc2c1 | 10.1021/ml2003058 | |||
| 5098885 | 198382 | None | 6 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 248 | 1 | 4 | 5 | 1.0 | O=C(O)c1cc(O)c(=O)c2c(O)c(O)ccc2c1 | 10.1021/ml2003058 | |||
| CHEMBL559337 | 198382 | None | 6 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 248 | 1 | 4 | 5 | 1.0 | O=C(O)c1cc(O)c(=O)c2c(O)c(O)ccc2c1 | 10.1021/ml2003058 | |||
| 164627011 | 186512 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 350 | 2 | 2 | 4 | 3.8 | Cc1c2nc(C(=O)O)cc(Cl)c2cc2c(Cl)cc(C(=O)O)nc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4876009 | 186512 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 350 | 2 | 2 | 4 | 3.8 | Cc1c2nc(C(=O)O)cc(Cl)c2cc2c(Cl)cc(C(=O)O)nc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 70694439 | 75331 | None | 0 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 222 | 1 | 1 | 3 | 3.0 | C#Cc1csc2c(C)c(C(=O)O)sc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037460 | 75331 | None | 0 | Human | Functional | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 222 | 1 | 1 | 3 | 3.0 | C#Cc1csc2c(C)c(C(=O)O)sc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 12897310 | 110484 | None | 1 | Mouse | Functional | pEC50 | = | 7.3 | 7.3 | 1 | 2 | ChEMBL | 354 | 2 | 4 | 4 | 1.4 | O=C(O)C(=O)Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)O)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL3245052 | 110484 | None | 1 | Mouse | Functional | pEC50 | = | 7.3 | 7.3 | 1 | 2 | ChEMBL | 354 | 2 | 4 | 4 | 1.4 | O=C(O)C(=O)Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)O)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 145971442 | 163122 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4175848 | 163122 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 2882 | 1208 | None | 41 | Mouse | Functional | pEC50 | = | 4.2 | 4.2 | -15 | 5 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| 741 | 1208 | None | 41 | Mouse | Functional | pEC50 | = | 4.2 | 4.2 | -15 | 5 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| 7608 | 1208 | None | 41 | Mouse | Functional | pEC50 | = | 4.2 | 4.2 | -15 | 5 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL428880 | 1208 | None | 41 | Mouse | Functional | pEC50 | = | 4.2 | 4.2 | -15 | 5 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| DB01003 | 1208 | None | 41 | Mouse | Functional | pEC50 | = | 4.2 | 4.2 | -15 | 5 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| 145971442 | 163122 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4175848 | 163122 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 2920 | 2997 | None | 64 | Human | Functional | pEC50 | = | 6.2 | 6.2 | 2398 | 2 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.6019/CHEMBL5442687 | |||
| 54742459 | 2997 | None | 64 | Human | Functional | pEC50 | = | 6.2 | 6.2 | 2398 | 2 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.6019/CHEMBL5442687 | |||
| 8546 | 2997 | None | 64 | Human | Functional | pEC50 | = | 6.2 | 6.2 | 2398 | 2 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.6019/CHEMBL5442687 | |||
| CHEMBL177880 | 2997 | None | 64 | Human | Functional | pEC50 | = | 6.2 | 6.2 | 2398 | 2 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.6019/CHEMBL5442687 | |||
| 5280343 | 188382 | None | 69 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -8 | 12 | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/ml2003058 | |||
| CHEMBL1520590 | 188382 | None | 69 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -8 | 12 | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/ml2003058 | |||
| CHEMBL50 | 188382 | None | 69 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -8 | 12 | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/ml2003058 | |||
| 154634332 | 185233 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4856506 | 185233 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 16103465 | 68090 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 254 | 1 | 1 | 4 | 4.2 | Cc1csc2c1sc1cc(C(=O)O)sc12 | 10.1021/jm200999f | |||
| CHEMBL1914587 | 68090 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 254 | 1 | 1 | 4 | 4.2 | Cc1csc2c1sc1cc(C(=O)O)sc12 | 10.1021/jm200999f | |||
| 16103462 | 68091 | None | 17 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 276 | 1 | 1 | 3 | 3.7 | Cc1c(C(=O)O)sc2c(Br)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL1914588 | 68091 | None | 17 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 276 | 1 | 1 | 3 | 3.7 | Cc1c(C(=O)O)sc2c(Br)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 172455183 | 196373 | None | 0 | Mouse | Functional | pEC50 | = | 7.2 | 7.2 | 2 | 2 | ChEMBL | 518 | 4 | 2 | 6 | 5.0 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CCCCC2)c1Cl)C(=O)OC1CCCCC1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5422437 | 196373 | None | 0 | Mouse | Functional | pEC50 | = | 7.2 | 7.2 | 2 | 2 | ChEMBL | 518 | 4 | 2 | 6 | 5.0 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CCCCC2)c1Cl)C(=O)OC1CCCCC1 | 10.1016/j.bmc.2023.117511 | |||
| 145952912 | 162539 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 361 | 3 | 2 | 4 | 3.0 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccc(F)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4166473 | 162539 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 361 | 3 | 2 | 4 | 3.0 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccc(F)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| 135399235 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml2003058 | |||
| 2919 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml2003058 | |||
| 5722 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml2003058 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml2003058 | |||
| 70682869 | 77410 | None | 0 | Human | Functional | pEC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 275 | 2 | 4 | 4 | 3.0 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1ccsc1 | 10.1021/ml300076u | |||
| CHEMBL2086422 | 77410 | None | 0 | Human | Functional | pEC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 275 | 2 | 4 | 4 | 3.0 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1ccsc1 | 10.1021/ml300076u | |||
| 145954727 | 162516 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 295 | 3 | 2 | 4 | 2.0 | CCC(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4166100 | 162516 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 295 | 3 | 2 | 4 | 2.0 | CCC(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| 145952912 | 162539 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 361 | 3 | 2 | 4 | 3.0 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccc(F)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4166473 | 162539 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 361 | 3 | 2 | 4 | 3.0 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccc(F)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| 70684936 | 77737 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 224 | 1 | 3 | 4 | 2.3 | Cc1c(C(=O)O)sc2cc(O)c(O)cc12 | 10.1021/ml300076u | |||
| CHEMBL2089228 | 77737 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 224 | 1 | 3 | 4 | 2.3 | Cc1c(C(=O)O)sc2cc(O)c(O)cc12 | 10.1021/ml300076u | |||
| 135399235 | 4134 | None | 41 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.0c01624 | |||
| 2919 | 4134 | None | 41 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.0c01624 | |||
| 5722 | 4134 | None | 41 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634321 | 186103 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2c3oc(=O)c(C(=O)O)cc3cc3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4870213 | 186103 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2c3oc(=O)c(C(=O)O)cc3cc3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 145954727 | 162516 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 295 | 3 | 2 | 4 | 2.0 | CCC(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4166100 | 162516 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 295 | 3 | 2 | 4 | 2.0 | CCC(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| 135399235 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmcl.2012.04.057 | |||
| 2919 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmcl.2012.04.057 | |||
| 5722 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1016/j.bmcl.2012.04.057 | |||
| 12897310 | 110484 | None | 1 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -1 | 2 | ChEMBL | 354 | 2 | 4 | 4 | 1.4 | O=C(O)C(=O)Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)O)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL3245052 | 110484 | None | 1 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -1 | 2 | ChEMBL | 354 | 2 | 4 | 4 | 1.4 | O=C(O)C(=O)Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)O)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 12897309 | 110478 | None | 1 | Mouse | Functional | pEC50 | = | 7.2 | 7.2 | 1 | 2 | ChEMBL | 410 | 4 | 2 | 6 | 2.4 | CCOC(=O)C(=O)Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL3245030 | 110478 | None | 1 | Mouse | Functional | pEC50 | = | 7.2 | 7.2 | 1 | 2 | ChEMBL | 410 | 4 | 2 | 6 | 2.4 | CCOC(=O)C(=O)Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 66561793 | 75337 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 258 | 2 | 2 | 3 | 3.3 | Cc1c(C(=O)O)[nH]c2c(-c3cccnc3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037466 | 75337 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 258 | 2 | 2 | 3 | 3.3 | Cc1c(C(=O)O)[nH]c2c(-c3cccnc3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 16103462 | 68091 | None | 17 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 276 | 1 | 1 | 3 | 3.7 | Cc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| CHEMBL1914588 | 68091 | None | 17 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 276 | 1 | 1 | 3 | 3.7 | Cc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| 16103462 | 68091 | None | 17 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 276 | 1 | 1 | 3 | 3.7 | Cc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/ml2003058 | |||
| CHEMBL1914588 | 68091 | None | 17 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 276 | 1 | 1 | 3 | 3.7 | Cc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/ml2003058 | |||
| 172459163 | 196166 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | 141 | 2 | ChEMBL | 320 | 3 | 4 | 6 | -0.3 | CN(C)c1c(NC(=O)C(=O)O)cc(C#N)cc1NC(=O)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5418035 | 196166 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | 141 | 2 | ChEMBL | 320 | 3 | 4 | 6 | -0.3 | CN(C)c1c(NC(=O)C(=O)O)cc(C#N)cc1NC(=O)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| 15774807 | 77718 | None | 24 | Human | Functional | pEC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 207 | 1 | 3 | 4 | 1.3 | Cn1c(C(=O)O)cc2cc(O)c(O)cc21 | 10.1021/ml300076u | |||
| CHEMBL2089192 | 77718 | None | 24 | Human | Functional | pEC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 207 | 1 | 3 | 4 | 1.3 | Cn1c(C(=O)O)cc2cc(O)c(O)cc21 | 10.1021/ml300076u | |||
| 45489602 | 59293 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 295 | 4 | 2 | 5 | 2.1 | COc1ccc(C(=O)Nc2ccccc2-c2nn[nH]n2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL1704189 | 59293 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 295 | 4 | 2 | 5 | 2.1 | COc1ccc(C(=O)Nc2ccccc2-c2nn[nH]n2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 154634336 | 186174 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccccc1-c1c2oc(=O)c(C(=O)O)cc2cc2cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4871203 | 186174 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccccc1-c1c2oc(=O)c(C(=O)O)cc2cc2cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 45489602 | 59293 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 295 | 4 | 2 | 5 | 2.1 | COc1ccc(C(=O)Nc2ccccc2-c2nn[nH]n2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL1704189 | 59293 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 295 | 4 | 2 | 5 | 2.1 | COc1ccc(C(=O)Nc2ccccc2-c2nn[nH]n2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 21337670 | 68082 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 321 | 0 | 0 | 4 | 4.1 | CC1=C(C#N)C(=C(C#N)C#N)OC12c1ccccc1-c1ccccc12 | 10.1021/jm200999f | |||
| CHEMBL1914579 | 68082 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 321 | 0 | 0 | 4 | 4.1 | CC1=C(C#N)C(=C(C#N)C#N)OC12c1ccccc1-c1ccccc12 | 10.1021/jm200999f | |||
| 12897322 | 110482 | None | 0 | Mouse | Functional | pEC50 | = | 7.2 | 7.2 | -1 | 2 | ChEMBL | 300 | 2 | 4 | 4 | 0.7 | Cc1cc(NC(=O)C(=O)O)c(Cl)c(NC(=O)C(=O)O)c1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL3245049 | 110482 | None | 0 | Mouse | Functional | pEC50 | = | 7.2 | 7.2 | -1 | 2 | ChEMBL | 300 | 2 | 4 | 4 | 0.7 | Cc1cc(NC(=O)C(=O)O)c(Cl)c(NC(=O)C(=O)O)c1 | 10.1016/j.bmc.2023.117511 | |||
| 70686064 | 75326 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 354 | 1 | 1 | 3 | 4.5 | Cc1c(C(=O)O)sc2c(Br)c(Br)sc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037454 | 75326 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 354 | 1 | 1 | 3 | 4.5 | Cc1c(C(=O)O)sc2c(Br)c(Br)sc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 44351698 | 120912 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 464 | 8 | 3 | 7 | 3.2 | O=C(O)c1cc(=O)c2c(CCC(O)CCc3cccc4oc(C(=O)O)cc(=O)c34)cccc2o1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL3558475 | 120912 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 464 | 8 | 3 | 7 | 3.2 | O=C(O)c1cc(=O)c2c(CCC(O)CCc3cccc4oc(C(=O)O)cc(=O)c34)cccc2o1 | 10.1021/acs.jmedchem.0c01624 | |||
| 5328791 | 207442 | None | 48 | Human | Functional | pEC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 189 | 2 | 2 | 3 | 1.4 | N#C/C(=C\c1ccc(O)cc1)C(=O)O | 10.1021/ml2003058 | |||
| CHEMBL76602 | 207442 | None | 48 | Human | Functional | pEC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 189 | 2 | 2 | 3 | 1.4 | N#C/C(=C\c1ccc(O)cc1)C(=O)O | 10.1021/ml2003058 | |||
| 1024 | 16495 | None | 63 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 330 | 3 | 4 | 6 | 0.6 | O=C(O)c1cc(C(=O)O)c2c(n1)C(=O)C(=O)c1cc(C(=O)O)[nH]c1-2 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL1235421 | 16495 | None | 63 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 330 | 3 | 4 | 6 | 0.6 | O=C(O)c1cc(C(=O)O)c2c(n1)C(=O)C(=O)c1cc(C(=O)O)[nH]c1-2 | 10.1021/acs.jmedchem.0c01624 | |||
| 5215 | 2386 | None | 74 | Human | Functional | pEC50 | = | 5.1 | 5.1 | -1 | 4 | ChEMBL | 286 | 1 | 4 | 6 | 2.3 | Oc1cc(O)c2c(c1)oc(cc2=O)c1ccc(c(c1)O)O | 10.1021/ml2003058 | |||
| 5280445 | 2386 | None | 74 | Human | Functional | pEC50 | = | 5.1 | 5.1 | -1 | 4 | ChEMBL | 286 | 1 | 4 | 6 | 2.3 | Oc1cc(O)c2c(c1)oc(cc2=O)c1ccc(c(c1)O)O | 10.1021/ml2003058 | |||
| CHEMBL151 | 2386 | None | 74 | Human | Functional | pEC50 | = | 5.1 | 5.1 | -1 | 4 | ChEMBL | 286 | 1 | 4 | 6 | 2.3 | Oc1cc(O)c2c(c1)oc(cc2=O)c1ccc(c(c1)O)O | 10.1021/ml2003058 | |||
| 20259231 | 77736 | None | 21 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 210 | 1 | 3 | 4 | 2.0 | O=C(O)c1cc2cc(O)c(O)cc2s1 | 10.1021/ml300076u | |||
| CHEMBL2089227 | 77736 | None | 21 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 210 | 1 | 3 | 4 | 2.0 | O=C(O)c1cc2cc(O)c(O)cc2s1 | 10.1021/ml300076u | |||
| 172457931 | 196452 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | 1 | 2 | ChEMBL | 434 | 4 | 2 | 6 | 2.6 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CC2)c1Cl)C(=O)OC1CC1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5424229 | 196452 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | 1 | 2 | ChEMBL | 434 | 4 | 2 | 6 | 2.6 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CC2)c1Cl)C(=O)OC1CC1 | 10.1016/j.bmc.2023.117511 | |||
| 70689184 | 77729 | None | 0 | Human | Functional | pEC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 313 | 3 | 5 | 4 | 2.6 | O=C(O)c1cccc(-c2c(C(=O)O)[nH]c3cc(O)c(O)cc23)c1 | 10.1021/ml300076u | |||
| CHEMBL2089220 | 77729 | None | 0 | Human | Functional | pEC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 313 | 3 | 5 | 4 | 2.6 | O=C(O)c1cccc(-c2c(C(=O)O)[nH]c3cc(O)c(O)cc23)c1 | 10.1021/ml300076u | |||
| 12897309 | 110478 | None | 1 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -1 | 2 | ChEMBL | 410 | 4 | 2 | 6 | 2.4 | CCOC(=O)C(=O)Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL3245030 | 110478 | None | 1 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -1 | 2 | ChEMBL | 410 | 4 | 2 | 6 | 2.4 | CCOC(=O)C(=O)Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 70697498 | 77719 | None | 0 | Human | Functional | pEC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 221 | 2 | 3 | 4 | 1.8 | CCn1c(C(=O)O)cc2cc(O)c(O)cc21 | 10.1021/ml300076u | |||
| CHEMBL2089193 | 77719 | None | 0 | Human | Functional | pEC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 221 | 2 | 3 | 4 | 1.8 | CCn1c(C(=O)O)cc2cc(O)c(O)cc21 | 10.1021/ml300076u | |||
| 12897314 | 194968 | None | 0 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 310 | 3 | 5 | 5 | -0.3 | Cc1c(NC(=O)C(=O)O)cc(C(=O)O)cc1NC(=O)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5394255 | 194968 | None | 0 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 310 | 3 | 5 | 5 | -0.3 | Cc1c(NC(=O)C(=O)O)cc(C(=O)O)cc1NC(=O)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| 12897301 | 110477 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | 40 | 2 | ChEMBL | 342 | 4 | 2 | 6 | 1.3 | CCOC(=O)C(=O)Nc1cccc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL3245010 | 110477 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | 40 | 2 | ChEMBL | 342 | 4 | 2 | 6 | 1.3 | CCOC(=O)C(=O)Nc1cccc(NC(=O)C(=O)OCC)c1Cl | 10.1016/j.bmc.2023.117511 | |||
| 326869 | 112874 | None | 2 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 314 | 2 | 4 | 4 | 1.1 | Cc1c2[nH]c(C(=O)O)cc(=O)c2cc2c(=O)cc(C(=O)O)[nH]c12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL3306990 | 112874 | None | 2 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 314 | 2 | 4 | 4 | 1.1 | Cc1c2[nH]c(C(=O)O)cc(=O)c2cc2c(=O)cc(C(=O)O)[nH]c12 | 10.1021/acs.jmedchem.0c01624 | |||
| 164610101 | 184981 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 342 | 4 | 2 | 6 | 2.5 | COc1cc(C(=O)O)nc2c(C)c3nc(C(=O)O)cc(OC)c3cc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4852667 | 184981 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 342 | 4 | 2 | 6 | 2.5 | COc1cc(C(=O)O)nc2c(C)c3nc(C(=O)O)cc(OC)c3cc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 2882 | 1208 | None | 41 | Human | Functional | pEC50 | = | 5.1 | 5.1 | -11 | 5 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| 741 | 1208 | None | 41 | Human | Functional | pEC50 | = | 5.1 | 5.1 | -11 | 5 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| 7608 | 1208 | None | 41 | Human | Functional | pEC50 | = | 5.1 | 5.1 | -11 | 5 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL428880 | 1208 | None | 41 | Human | Functional | pEC50 | = | 5.1 | 5.1 | -11 | 5 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| DB01003 | 1208 | None | 41 | Human | Functional | pEC50 | = | 5.1 | 5.1 | -11 | 5 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| 5280343 | 188382 | None | 69 | Human | Functional | pEC50 | = | 5.1 | 5.1 | -8 | 12 | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/ml2003058 | |||
| CHEMBL1520590 | 188382 | None | 69 | Human | Functional | pEC50 | = | 5.1 | 5.1 | -8 | 12 | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/ml2003058 | |||
| CHEMBL50 | 188382 | None | 69 | Human | Functional | pEC50 | = | 5.1 | 5.1 | -8 | 12 | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/ml2003058 | |||
| 12126688 | 110479 | None | 0 | Mouse | Functional | pEC50 | = | 5.1 | 5.1 | -1 | 2 | ChEMBL | 252 | 2 | 4 | 4 | -0.3 | O=C(O)C(=O)Nc1cccc(NC(=O)C(=O)O)c1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL3245041 | 110479 | None | 0 | Mouse | Functional | pEC50 | = | 5.1 | 5.1 | -1 | 2 | ChEMBL | 252 | 2 | 4 | 4 | -0.3 | O=C(O)C(=O)Nc1cccc(NC(=O)C(=O)O)c1 | 10.1016/j.bmc.2023.117511 | |||
| 154634314 | 186715 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccccc1-c1cc2cc(C(=O)O)c(=O)oc2c2cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4878979 | 186715 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccccc1-c1cc2cc(C(=O)O)c(=O)oc2c2cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 145953203 | 162633 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 403 | 5 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)cc1OC | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4167991 | 162633 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 403 | 5 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)cc1OC | 10.1021/acsmedchemlett.7b00510 | |||
| 16103462 | 68091 | None | 17 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 276 | 1 | 1 | 3 | 3.7 | Cc1c(C(=O)O)sc2c(Br)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL1914588 | 68091 | None | 17 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 276 | 1 | 1 | 3 | 3.7 | Cc1c(C(=O)O)sc2c(Br)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 145953203 | 162633 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 403 | 5 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)cc1OC | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4167991 | 162633 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 403 | 5 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)cc1OC | 10.1021/acsmedchemlett.7b00510 | |||
| 70681839 | 75338 | None | 0 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 221 | 2 | 2 | 2 | 3.1 | Cc1c(C(=O)O)[nH]c2c(C3CC3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037467 | 75338 | None | 0 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 221 | 2 | 2 | 2 | 3.1 | Cc1c(C(=O)O)[nH]c2c(C3CC3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 70689183 | 77728 | None | 0 | Human | Functional | pEC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 270 | 2 | 4 | 4 | 2.3 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1cccnc1 | 10.1021/ml300076u | |||
| CHEMBL2089219 | 77728 | None | 0 | Human | Functional | pEC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 270 | 2 | 4 | 4 | 2.3 | O=C(O)c1[nH]c2cc(O)c(O)cc2c1-c1cccnc1 | 10.1021/ml300076u | |||
| 145952039 | 162903 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccccc1C(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4172440 | 162903 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccccc1C(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| 145952039 | 162903 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccccc1C(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4172440 | 162903 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccccc1C(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| 145974046 | 163107 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.2 | Cc1cccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4175617 | 163107 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.2 | Cc1cccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| 151271218 | 186261 | None | 0 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 300 | 2 | 2 | 4 | 3.0 | O=C(O)c1cc2cc(-c3ccc(F)cc3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4872368 | 186261 | None | 0 | Human | Functional | pEC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 300 | 2 | 2 | 4 | 3.0 | O=C(O)c1cc2cc(-c3ccc(F)cc3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 145959908 | 162156 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccccc1Cl | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4160515 | 162156 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccccc1Cl | 10.1021/acsmedchemlett.7b00510 | |||
| 145952453 | 162883 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 343 | 3 | 2 | 4 | 2.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccccc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4172188 | 162883 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 343 | 3 | 2 | 4 | 2.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccccc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 145959908 | 162156 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccccc1Cl | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4160515 | 162156 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccccc1Cl | 10.1021/acsmedchemlett.7b00510 | |||
| 145952453 | 162883 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 343 | 3 | 2 | 4 | 2.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccccc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4172188 | 162883 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 343 | 3 | 2 | 4 | 2.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccccc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 145974046 | 163107 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.2 | Cc1cccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4175617 | 163107 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.2 | Cc1cccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| 70690213 | 75339 | None | 0 | Human | Functional | pEC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 273 | 1 | 1 | 3 | 3.0 | Cc1c(C(=O)O)n(C)c2c(Br)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037468 | 75339 | None | 0 | Human | Functional | pEC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 273 | 1 | 1 | 3 | 3.0 | Cc1c(C(=O)O)n(C)c2c(Br)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 70684936 | 77737 | None | 0 | Human | Functional | pEC50 | = | 4.0 | 4.0 | - | 1 | ChEMBL | 224 | 1 | 3 | 4 | 2.3 | Cc1c(C(=O)O)sc2cc(O)c(O)cc12 | 10.1021/ml300076u | |||
| CHEMBL2089228 | 77737 | None | 0 | Human | Functional | pEC50 | = | 4.0 | 4.0 | - | 1 | ChEMBL | 224 | 1 | 3 | 4 | 2.3 | Cc1c(C(=O)O)sc2cc(O)c(O)cc12 | 10.1021/ml300076u | |||
| 172459163 | 196166 | None | 0 | Mouse | Functional | pEC50 | = | 5.0 | 5.0 | -141 | 2 | ChEMBL | 320 | 3 | 4 | 6 | -0.3 | CN(C)c1c(NC(=O)C(=O)O)cc(C#N)cc1NC(=O)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5418035 | 196166 | None | 0 | Mouse | Functional | pEC50 | = | 5.0 | 5.0 | -141 | 2 | ChEMBL | 320 | 3 | 4 | 6 | -0.3 | CN(C)c1c(NC(=O)C(=O)O)cc(C#N)cc1NC(=O)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| 154634335 | 184589 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1cccc(-c2c3oc(=O)c(C(=O)O)cc3cc3cc(C(=O)O)c(=O)oc23)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4847100 | 184589 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1cccc(-c2c3oc(=O)c(C(=O)O)cc3cc3cc(C(=O)O)c(=O)oc23)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634316 | 186448 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 426 | 4 | 2 | 7 | 3.1 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)c(F)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4875009 | 186448 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 426 | 4 | 2 | 7 | 3.1 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)c(F)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| 172454119 | 195785 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 33 | 2 | ChEMBL | 307 | 3 | 4 | 6 | -0.4 | COc1c(NC(=O)C(=O)O)cc(C#N)cc1NC(=O)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5410743 | 195785 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 33 | 2 | ChEMBL | 307 | 3 | 4 | 6 | -0.4 | COc1c(NC(=O)C(=O)O)cc(C#N)cc1NC(=O)C(=O)O | 10.1016/j.bmc.2023.117511 | |||
| 172444421 | 195231 | None | 0 | Mouse | Functional | pEC50 | = | 7.0 | 7.0 | 1 | 2 | ChEMBL | 462 | 4 | 2 | 6 | 3.4 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CCC2)c1Cl)C(=O)OC1CCC1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5399225 | 195231 | None | 0 | Mouse | Functional | pEC50 | = | 7.0 | 7.0 | 1 | 2 | ChEMBL | 462 | 4 | 2 | 6 | 3.4 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CCC2)c1Cl)C(=O)OC1CCC1 | 10.1016/j.bmc.2023.117511 | |||
| 53258899 | 68089 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 268 | 6 | 1 | 3 | 4.8 | CCCCCCc1csc2cc(C(=O)O)sc12 | 10.1021/jm200999f | |||
| CHEMBL1914586 | 68089 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 268 | 6 | 1 | 3 | 4.8 | CCCCCCc1csc2cc(C(=O)O)sc12 | 10.1021/jm200999f | |||
| 57697 | 14472 | None | 29 | Rat | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 228 | 1 | 1 | 6 | 0.2 | Cc1cccn2c(=O)c(-c3nnn[nH]3)cnc12 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL1201198 | 14472 | None | 29 | Rat | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 228 | 1 | 1 | 6 | 0.2 | Cc1cccn2c(=O)c(-c3nnn[nH]3)cnc12 | 10.1021/acsmedchemlett.7b00510 | |||
| 70683939 | 75332 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 238 | 2 | 1 | 3 | 3.8 | Cc1c(C(=O)O)sc2c(C3CC3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037461 | 75332 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 238 | 2 | 1 | 3 | 3.8 | Cc1c(C(=O)O)sc2c(C3CC3)csc12 | 10.1016/j.bmcl.2012.04.057 | |||
| 70683938 | 75328 | None | 1 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 200 | 1 | 2 | 4 | 2.4 | O=C(O)c1sc2ccsc2c1O | 10.1016/j.bmcl.2012.04.057 | |||
| CHEMBL2037457 | 75328 | None | 1 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 200 | 1 | 2 | 4 | 2.4 | O=C(O)c1sc2ccsc2c1O | 10.1016/j.bmcl.2012.04.057 | |||
| 172444421 | 195231 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 462 | 4 | 2 | 6 | 3.4 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CCC2)c1Cl)C(=O)OC1CCC1 | 10.1016/j.bmc.2023.117511 | |||
| CHEMBL5399225 | 195231 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 462 | 4 | 2 | 6 | 3.4 | O=C(Nc1cc(C(F)(F)F)cc(NC(=O)C(=O)OC2CCC2)c1Cl)C(=O)OC1CCC1 | 10.1016/j.bmc.2023.117511 | |||
| 5328791 | 207442 | None | 48 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 189 | 2 | 2 | 3 | 1.4 | N#C/C(=C\c1ccc(O)cc1)C(=O)O | 10.1021/ml2003058 | |||
| CHEMBL76602 | 207442 | None | 48 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 189 | 2 | 2 | 3 | 1.4 | N#C/C(=C\c1ccc(O)cc1)C(=O)O | 10.1021/ml2003058 | |||
| 154634333 | 185321 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 352 | 2 | 2 | 6 | 2.4 | O=C(O)c1cc2c3ccccc3c3cc(C(=O)O)c(=O)oc3c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4857772 | 185321 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 352 | 2 | 2 | 6 | 2.4 | O=C(O)c1cc2c3ccccc3c3cc(C(=O)O)c(=O)oc3c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 326869 | 112874 | None | 2 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 314 | 2 | 4 | 4 | 1.1 | Cc1c2[nH]c(C(=O)O)cc(=O)c2cc2c(=O)cc(C(=O)O)[nH]c12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL3306990 | 112874 | None | 2 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 314 | 2 | 4 | 4 | 1.1 | Cc1c2[nH]c(C(=O)O)cc(=O)c2cc2c(=O)cc(C(=O)O)[nH]c12 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634333 | 185321 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 352 | 2 | 2 | 6 | 2.4 | O=C(O)c1cc2c3ccccc3c3cc(C(=O)O)c(=O)oc3c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4857772 | 185321 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 352 | 2 | 2 | 6 | 2.4 | O=C(O)c1cc2c3ccccc3c3cc(C(=O)O)c(=O)oc3c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 3110120 | 41932 | None | 6 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 474 | 10 | 3 | 5 | 5.2 | CCCCCOC(=O)c1ccc(NC(=O)c2cccc(NC(=O)c3ccccc3C(=O)O)c2)cc1 | nan | |||
| CHEMBL1494365 | 41932 | None | 6 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 474 | 10 | 3 | 5 | 5.2 | CCCCCOC(=O)c1ccc(NC(=O)c2cccc(NC(=O)c3ccccc3C(=O)O)c2)cc1 | nan | |||
| 644413 | 33539 | None | 5 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 315 | 1 | 1 | 5 | 2.0 | CN1C=CC2=C(C#N)C(N)C(C#N)(C#N)C(c3ccccc3)C2C1 | nan | |||
| CHEMBL1420573 | 33539 | None | 5 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 315 | 1 | 1 | 5 | 2.0 | CN1C=CC2=C(C#N)C(N)C(C#N)(C#N)C(c3ccccc3)C2C1 | nan | |||
| 9581006 | 59406 | None | 1 | Human | Functional | pIC50 | = | 6 | 6.0 | 12 | 3 | ChEMBL | 379 | 5 | 2 | 6 | 3.0 | COC(=O)c1cnn(-c2ccccc2)c1/C=N/NC(=S)Nc1ccccc1 | nan | |||
| CHEMBL1709028 | 59406 | None | 1 | Human | Functional | pIC50 | = | 6 | 6.0 | 12 | 3 | ChEMBL | 379 | 5 | 2 | 6 | 3.0 | COC(=O)c1cnn(-c2ccccc2)c1/C=N/NC(=S)Nc1ccccc1 | nan | |||
| 18296 | 69884 | None | 1 | Human | Functional | pIC50 | = | 6 | 6.0 | 6 | 2 | ChEMBL | 379 | 4 | 0 | 3 | 6.1 | CCN1/C(=C/C(C)=C/c2sc3ccccc3[n+]2CC)Sc2ccccc21 | nan | |||
| 5351211 | 69884 | None | 1 | Human | Functional | pIC50 | = | 6 | 6.0 | 6 | 2 | ChEMBL | 379 | 4 | 0 | 3 | 6.1 | CCN1/C(=C/C(C)=C/c2sc3ccccc3[n+]2CC)Sc2ccccc21 | nan | |||
| 5474842 | 69884 | None | 1 | Human | Functional | pIC50 | = | 6 | 6.0 | 6 | 2 | ChEMBL | 379 | 4 | 0 | 3 | 6.1 | CCN1/C(=C/C(C)=C/c2sc3ccccc3[n+]2CC)Sc2ccccc21 | nan | |||
| 6326610 | 69884 | None | 1 | Human | Functional | pIC50 | = | 6 | 6.0 | 6 | 2 | ChEMBL | 379 | 4 | 0 | 3 | 6.1 | CCN1/C(=C/C(C)=C/c2sc3ccccc3[n+]2CC)Sc2ccccc21 | nan | |||
| CHEMBL193872 | 69884 | None | 1 | Human | Functional | pIC50 | = | 6 | 6.0 | 6 | 2 | ChEMBL | 379 | 4 | 0 | 3 | 6.1 | CCN1/C(=C/C(C)=C/c2sc3ccccc3[n+]2CC)Sc2ccccc21 | nan | |||
| CHEMBL466853 | 69884 | None | 1 | Human | Functional | pIC50 | = | 6 | 6.0 | 6 | 2 | ChEMBL | 379 | 4 | 0 | 3 | 6.1 | CCN1/C(=C/C(C)=C/c2sc3ccccc3[n+]2CC)Sc2ccccc21 | nan | |||
| 152550147 | 185434 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 300 | 2 | 2 | 4 | 3.0 | O=C(O)c1cc2cc(-c3cccc(F)c3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4859675 | 185434 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 300 | 2 | 2 | 4 | 3.0 | O=C(O)c1cc2cc(-c3cccc(F)c3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 154634315 | 184984 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 396 | 3 | 2 | 6 | 3.1 | O=C(O)c1cc2c(oc1=O)c(-c1ccc(F)cc1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4852718 | 184984 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 396 | 3 | 2 | 6 | 3.1 | O=C(O)c1cc2c(oc1=O)c(-c1ccc(F)cc1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 53257379 | 68083 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 363 | 1 | 0 | 4 | 5.0 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1Cl | 10.1021/jm200999f | |||
| CHEMBL1914580 | 68083 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 363 | 1 | 0 | 4 | 5.0 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1Cl | 10.1021/jm200999f | |||
| 53258793 | 68092 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 374 | 8 | 1 | 3 | 6.3 | CCCCCCCCc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| CHEMBL1914589 | 68092 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 374 | 8 | 1 | 3 | 6.3 | CCCCCCCCc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| 135399235 | 4134 | None | 41 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm200999f | |||
| 2919 | 4134 | None | 41 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm200999f | |||
| 5722 | 4134 | None | 41 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm200999f | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm200999f | |||
| 151271218 | 186261 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 300 | 2 | 2 | 4 | 3.0 | O=C(O)c1cc2cc(-c3ccc(F)cc3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4872368 | 186261 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 300 | 2 | 2 | 4 | 3.0 | O=C(O)c1cc2cc(-c3ccc(F)cc3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 4811966 | 43703 | None | 4 | Human | Functional | pIC50 | = | 6.0 | 6.0 | 2 | 5 | ChEMBL | 383 | 4 | 1 | 4 | 3.3 | CC(NC(=O)Cn1ncc(Cl)c(Cl)c1=O)C12CC3CC(CC(C3)C1)C2 | nan | |||
| CHEMBL1510156 | 43703 | None | 4 | Human | Functional | pIC50 | = | 6.0 | 6.0 | 2 | 5 | ChEMBL | 383 | 4 | 1 | 4 | 3.3 | CC(NC(=O)Cn1ncc(Cl)c(Cl)c1=O)C12CC3CC(CC(C3)C1)C2 | nan | |||
| 512282 | 758 | None | 42 | Human | Functional | pIC50 | = | 6.0 | 6.0 | -158 | 5 | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.6019/CHEMBL5442687 | |||
| 767 | 758 | None | 42 | Human | Functional | pIC50 | = | 6.0 | 6.0 | -158 | 5 | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.6019/CHEMBL5442687 | |||
| CHEMBL232656 | 758 | None | 42 | Human | Functional | pIC50 | = | 6.0 | 6.0 | -158 | 5 | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.6019/CHEMBL5442687 | |||
| 16103462 | 68091 | None | 17 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 276 | 1 | 1 | 3 | 3.7 | Cc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| CHEMBL1914588 | 68091 | None | 17 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 276 | 1 | 1 | 3 | 3.7 | Cc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| 145957901 | 162169 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2ccc(Br)cc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4160729 | 162169 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2ccc(Br)cc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 145951357 | 162859 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 411 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(Cl)cc1Cl | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4171772 | 162859 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 411 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(Cl)cc1Cl | 10.1021/acsmedchemlett.7b00510 | |||
| 5602180 | 55522 | None | 3 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 1 | 2 | ChEMBL | 334 | 1 | 1 | 2 | 4.1 | CC1(C)Cc2c(ccc3ccccc23)/C(=C/C(=O)N2CCCCC2)N1 | nan | |||
| CHEMBL1416442 | 55522 | None | 3 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 1 | 2 | ChEMBL | 334 | 1 | 1 | 2 | 4.1 | CC1(C)Cc2c(ccc3ccccc23)/C(=C/C(=O)N2CCCCC2)N1 | nan | |||
| CHEMBL1620242 | 55522 | None | 3 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 1 | 2 | ChEMBL | 334 | 1 | 1 | 2 | 4.1 | CC1(C)Cc2c(ccc3ccccc23)/C(=C/C(=O)N2CCCCC2)N1 | nan | |||
| 16195500 | 41745 | None | 8 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 441 | 4 | 2 | 5 | 4.9 | N=C1/C(=C/c2ccc(-c3cccc(C(=O)O)c3)o2)C(=O)N=C2SC=C(c3ccccc3)N12 | nan | |||
| CHEMBL1492565 | 41745 | None | 8 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 441 | 4 | 2 | 5 | 4.9 | N=C1/C(=C/c2ccc(-c3cccc(C(=O)O)c3)o2)C(=O)N=C2SC=C(c3ccccc3)N12 | nan | |||
| 9581008 | 59565 | None | 3 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 353 | 4 | 2 | 6 | 1.4 | CNC(=S)N/N=C/c1c(C(=O)OC)cnn1-c1ccc(F)cc1F | nan | |||
| CHEMBL1716874 | 59565 | None | 3 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 353 | 4 | 2 | 6 | 1.4 | CNC(=S)N/N=C/c1c(C(=O)OC)cnn1-c1ccc(F)cc1F | nan | |||
| 150386356 | 185252 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 312 | 3 | 2 | 5 | 2.9 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3cc2O)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4856916 | 185252 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 312 | 3 | 2 | 5 | 2.9 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3cc2O)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 2963825 | 47716 | None | 7 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 382 | 4 | 1 | 6 | 4.4 | O=C(Nc1nc2ccccc2s1)c1ccc(N2CCCCC2)c([N+](=O)[O-])c1 | nan | |||
| CHEMBL1547464 | 47716 | None | 7 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 382 | 4 | 1 | 6 | 4.4 | O=C(Nc1nc2ccccc2s1)c1ccc(N2CCCCC2)c([N+](=O)[O-])c1 | nan | |||
| 2259994 | 41419 | None | 4 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 262 | 2 | 0 | 4 | 1.9 | CN1C(=O)/C(=C\c2ccc(N(C)C)cc2)OC1=S | nan | |||
| CHEMBL1490312 | 41419 | None | 4 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 262 | 2 | 0 | 4 | 1.9 | CN1C(=O)/C(=C\c2ccc(N(C)C)cc2)OC1=S | nan | |||
| 135549592 | 108498 | None | 3 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 369 | 7 | 4 | 6 | 1.4 | COc1ccc(/C=C\C(=O)NCC(=O)N/N=C/c2ccc(O)cc2O)cc1 | nan | |||
| CHEMBL3198952 | 108498 | None | 3 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 369 | 7 | 4 | 6 | 1.4 | COc1ccc(/C=C\C(=O)NCC(=O)N/N=C/c2ccc(O)cc2O)cc1 | nan | |||
| 1416931 | 23426 | None | 2 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 426 | 7 | 2 | 5 | 4.0 | O=C(CCCN1C(=O)/C(=C\c2ccccc2)SC1=S)Nc1ccc(C(=O)O)cc1 | nan | |||
| CHEMBL1333032 | 23426 | None | 2 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 426 | 7 | 2 | 5 | 4.0 | O=C(CCCN1C(=O)/C(=C\c2ccccc2)SC1=S)Nc1ccc(C(=O)O)cc1 | nan | |||
| 1348328 | 31794 | None | 4 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 16 | 2 | ChEMBL | 436 | 8 | 2 | 5 | 4.4 | O=C(CCCN1C(=O)S/C(=C/C=C/c2ccccc2)C1=O)Nc1ccc(C(=O)O)cc1 | nan | |||
| CHEMBL1406190 | 31794 | None | 4 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 16 | 2 | ChEMBL | 436 | 8 | 2 | 5 | 4.4 | O=C(CCCN1C(=O)S/C(=C/C=C/c2ccccc2)C1=O)Nc1ccc(C(=O)O)cc1 | nan | |||
| 5334489 | 45978 | None | 4 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 10 | 2 | ChEMBL | 374 | 7 | 1 | 4 | 5.3 | CCN(CC)c1ccc(/C=C(/C#N)c2nc3ccccc3[nH]2)c(OC(C)C)c1 | nan | |||
| CHEMBL1532412 | 45978 | None | 4 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 10 | 2 | ChEMBL | 374 | 7 | 1 | 4 | 5.3 | CCN(CC)c1ccc(/C=C(/C#N)c2nc3ccccc3[nH]2)c(OC(C)C)c1 | nan | |||
| 4137407 | 29820 | None | 2 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 438 | 3 | 1 | 7 | 4.6 | Cc1nc(N2CCC(C)CC2)c2c(C)c(C(=O)Nc3ccc4c(c3)OCCO4)sc2n1 | nan | |||
| CHEMBL1387336 | 29820 | None | 2 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 438 | 3 | 1 | 7 | 4.6 | Cc1nc(N2CCC(C)CC2)c2c(C)c(C(=O)Nc3ccc4c(c3)OCCO4)sc2n1 | nan | |||
| 152684818 | 185098 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 312 | 3 | 2 | 5 | 2.9 | COc1ccccc1-c1cc2cc(C(=O)O)c(=O)oc2cc1O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4854346 | 185098 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 312 | 3 | 2 | 5 | 2.9 | COc1ccccc1-c1cc2cc(C(=O)O)c(=O)oc2cc1O | 10.1021/acs.jmedchem.0c01624 | |||
| 5733585 | 40983 | None | 6 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 486 | 9 | 2 | 7 | 4.0 | COc1ccc(/C=C2\SC(=S)N(CCCC(=O)Nc3cccc(C(=O)O)c3)C2=O)cc1OC | nan | |||
| CHEMBL1487024 | 40983 | None | 6 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 486 | 9 | 2 | 7 | 4.0 | COc1ccc(/C=C2\SC(=S)N(CCCC(=O)Nc3cccc(C(=O)O)c3)C2=O)cc1OC | nan | |||
| 655684 | 41102 | None | 4 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 383 | 1 | 1 | 5 | 3.3 | CN1CC=C2C(C#N)=C(N)C(C#N)(C#N)C(c3cccc(Cl)c3Cl)C2C1 | nan | |||
| CHEMBL1487918 | 41102 | None | 4 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 383 | 1 | 1 | 5 | 3.3 | CN1CC=C2C(C#N)=C(N)C(C#N)(C#N)C(c3cccc(Cl)c3Cl)C2C1 | nan | |||
| 9990345 | 68087 | None | 32 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 199 | 0 | 0 | 4 | 1.9 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)C | 10.1021/jm200999f | |||
| CHEMBL1914584 | 68087 | None | 32 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 199 | 0 | 0 | 4 | 1.9 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)C | 10.1021/jm200999f | |||
| 135399235 | 4134 | None | 41 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm200999f | |||
| 2919 | 4134 | None | 41 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm200999f | |||
| 5722 | 4134 | None | 41 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm200999f | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm200999f | |||
| 6484583 | 37247 | None | 1 | Human | Functional | pIC50 | = | 4.9 | 4.9 | -89 | 3 | ChEMBL | 410 | 5 | 1 | 5 | 2.6 | COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL1453578 | 37247 | None | 1 | Human | Functional | pIC50 | = | 4.9 | 4.9 | -89 | 3 | ChEMBL | 410 | 5 | 1 | 5 | 2.6 | COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)c1ccc(Cl)cc1 | nan | |||
| 9581013 | 59730 | None | 3 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 351 | 4 | 2 | 6 | 1.7 | CNC(=S)N/N=C/c1c(C(=O)OC)cnn1-c1ccc(Cl)cc1 | nan | |||
| CHEMBL1723578 | 59730 | None | 3 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 351 | 4 | 2 | 6 | 1.7 | CNC(=S)N/N=C/c1c(C(=O)OC)cnn1-c1ccc(Cl)cc1 | nan | |||
| 1348329 | 26256 | None | 8 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 3 | 2 | ChEMBL | 436 | 8 | 2 | 5 | 4.4 | O=C(CCCN1C(=O)S/C(=C\C=C\c2ccccc2)C1=O)Nc1ccc(C(=O)O)cc1 | nan | |||
| CHEMBL1357976 | 26256 | None | 8 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 3 | 2 | ChEMBL | 436 | 8 | 2 | 5 | 4.4 | O=C(CCCN1C(=O)S/C(=C\C=C\c2ccccc2)C1=O)Nc1ccc(C(=O)O)cc1 | nan | |||
| 145952561 | 163054 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 411 | 3 | 2 | 4 | 3.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccc(C(F)(F)F)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4174783 | 163054 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 411 | 3 | 2 | 4 | 3.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccc(C(F)(F)F)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| 13950957 | 157420 | None | 8 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 284 | 1 | 2 | 4 | 2.0 | O=C(O)c1cc2cc(Br)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4077503 | 157420 | None | 8 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 284 | 1 | 2 | 4 | 2.0 | O=C(O)c1cc2cc(Br)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 2961024 | 44945 | None | 4 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 452 | 8 | 2 | 4 | 5.7 | CCOc1ccc(NC(=O)C(C)Oc2ccccc2C(=O)Nc2ccc(C)c(Cl)c2)cc1 | nan | |||
| CHEMBL1523126 | 44945 | None | 4 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 452 | 8 | 2 | 4 | 5.7 | CCOc1ccc(NC(=O)C(C)Oc2ccccc2C(=O)Nc2ccc(C)c(Cl)c2)cc1 | nan | |||
| 149708825 | 186497 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 300 | 2 | 2 | 4 | 3.0 | O=C(O)c1cc2cc(-c3ccccc3F)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4875771 | 186497 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 300 | 2 | 2 | 4 | 3.0 | O=C(O)c1cc2cc(-c3ccccc3F)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 24792210 | 55207 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 391 | 5 | 1 | 4 | 5.0 | CN(C)c1ccc(-c2sc(Nc3ccccc3)n[n+]2-c2ccc(F)cc2)cc1 | nan | |||
| CHEMBL1351967 | 55207 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 391 | 5 | 1 | 4 | 5.0 | CN(C)c1ccc(-c2sc(Nc3ccccc3)n[n+]2-c2ccc(F)cc2)cc1 | nan | |||
| CHEMBL1617564 | 55207 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 391 | 5 | 1 | 4 | 5.0 | CN(C)c1ccc(-c2sc(Nc3ccccc3)n[n+]2-c2ccc(F)cc2)cc1 | nan | |||
| 145953959 | 162772 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 411 | 3 | 2 | 4 | 3.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(C(F)(F)F)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4170205 | 162772 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 411 | 3 | 2 | 4 | 3.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(C(F)(F)F)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 72652 | 34857 | None | 44 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 309 | 0 | 0 | 3 | 3.5 | O=c1cc(C(F)(F)F)c2cc3c4c(c2o1)CCCN4CCC3 | nan | |||
| CHEMBL1431610 | 34857 | None | 44 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 309 | 0 | 0 | 3 | 3.5 | O=c1cc(C(F)(F)F)c2cc3c4c(c2o1)CCCN4CCC3 | nan | |||
| 151577785 | 186659 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 312 | 3 | 2 | 5 | 2.9 | COc1cccc(-c2cc3cc(C(=O)O)c(=O)oc3cc2O)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4878047 | 186659 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 312 | 3 | 2 | 5 | 2.9 | COc1cccc(-c2cc3cc(C(=O)O)c(=O)oc3cc2O)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| 135475176 | 108080 | None | 8 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 387 | 2 | 1 | 4 | 5.1 | CC12CCC(C/C1=N\NC1=NC(=O)/C(=C\c3ccc(Cl)cc3)S1)C2(C)C | nan | |||
| 135517099 | 108080 | None | 8 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 387 | 2 | 1 | 4 | 5.1 | CC12CCC(C/C1=N\NC1=NC(=O)/C(=C\c3ccc(Cl)cc3)S1)C2(C)C | nan | |||
| CHEMBL3194571 | 108080 | None | 8 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 387 | 2 | 1 | 4 | 5.1 | CC12CCC(C/C1=N\NC1=NC(=O)/C(=C\c3ccc(Cl)cc3)S1)C2(C)C | nan | |||
| 2745687 | 933 | None | 27 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 10 | 3 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | nan | |||
| 9741 | 933 | None | 27 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 10 | 3 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | nan | |||
| CHEMBL1708510 | 933 | None | 27 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 10 | 3 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | nan | |||
| 1346721 | 29827 | None | 9 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 1 | 2 | ChEMBL | 440 | 7 | 2 | 5 | 4.3 | Cc1ccc(/C=C2\SC(=S)N(CCCC(=O)Nc3cccc(C(=O)O)c3)C2=O)cc1 | nan | |||
| CHEMBL1387413 | 29827 | None | 9 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 1 | 2 | ChEMBL | 440 | 7 | 2 | 5 | 4.3 | Cc1ccc(/C=C2\SC(=S)N(CCCC(=O)Nc3cccc(C(=O)O)c3)C2=O)cc1 | nan | |||
| 145956623 | 162107 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 391 | 4 | 2 | 5 | 3.0 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)c(F)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4159575 | 162107 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 391 | 4 | 2 | 5 | 3.0 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)c(F)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| 3153499 | 32584 | None | 13 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 344 | 3 | 0 | 5 | 2.5 | CS(=O)(=O)N1N=C(c2ccccc2)CC1c1ccc2c(c1)OCO2 | nan | |||
| CHEMBL1412529 | 32584 | None | 13 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 344 | 3 | 0 | 5 | 2.5 | CS(=O)(=O)N1N=C(c2ccccc2)CC1c1ccc2c(c1)OCO2 | nan | |||
| 16196320 | 55075 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 353 | 3 | 0 | 3 | 4.4 | CC1=CC(=Cc2sc3ccccc3[n+]2C)C=C(C)N1CC1CCCO1 | nan | |||
| 3394229 | 55075 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 353 | 3 | 0 | 3 | 4.4 | CC1=CC(=Cc2sc3ccccc3[n+]2C)C=C(C)N1CC1CCCO1 | nan | |||
| 5813410 | 55075 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 353 | 3 | 0 | 3 | 4.4 | CC1=CC(=Cc2sc3ccccc3[n+]2C)C=C(C)N1CC1CCCO1 | nan | |||
| CHEMBL1308547 | 55075 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 353 | 3 | 0 | 3 | 4.4 | CC1=CC(=Cc2sc3ccccc3[n+]2C)C=C(C)N1CC1CCCO1 | nan | |||
| CHEMBL1616589 | 55075 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 353 | 3 | 0 | 3 | 4.4 | CC1=CC(=Cc2sc3ccccc3[n+]2C)C=C(C)N1CC1CCCO1 | nan | |||
| 1382708 | 29872 | None | 8 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 426 | 7 | 2 | 5 | 4.6 | O=C(CCCN1C(=O)S/C(=C/c2ccccc2)C1=S)Nc1ccc(C(=O)O)cc1 | nan | |||
| CHEMBL1387749 | 29872 | None | 8 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 426 | 7 | 2 | 5 | 4.6 | O=C(CCCN1C(=O)S/C(=C/c2ccccc2)C1=S)Nc1ccc(C(=O)O)cc1 | nan | |||
| 4362054 | 26099 | None | 5 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 495 | 9 | 2 | 8 | 4.3 | CCOc1ccc(NC(=O)CSc2nc3ccsc3c(=O)n2Cc2ccc(C(=O)O)cc2)cc1 | nan | |||
| CHEMBL1355774 | 26099 | None | 5 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 495 | 9 | 2 | 8 | 4.3 | CCOc1ccc(NC(=O)CSc2nc3ccsc3c(=O)n2Cc2ccc(C(=O)O)cc2)cc1 | nan | |||
| 152727536 | 184593 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 288 | 2 | 2 | 5 | 2.9 | O=C(O)c1cc2cc(-c3cccs3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4847144 | 184593 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 288 | 2 | 2 | 5 | 2.9 | O=C(O)c1cc2cc(-c3cccs3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 24761764 | 52829 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 387 | 5 | 1 | 3 | 4.3 | CC(NS(=O)(=O)OCC(Cl)(Cl)Cl)c1ccc(C(C)(C)C)cc1 | nan | |||
| CHEMBL1595152 | 52829 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 387 | 5 | 1 | 3 | 4.3 | CC(NS(=O)(=O)OCC(Cl)(Cl)Cl)c1ccc(C(C)(C)C)cc1 | nan | |||
| 16103482 | 68088 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 268 | 6 | 1 | 3 | 4.8 | CCCCCCc1c(C(=O)O)sc2ccsc12 | 10.1021/jm200999f | |||
| CHEMBL1914585 | 68088 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 268 | 6 | 1 | 3 | 4.8 | CCCCCCc1c(C(=O)O)sc2ccsc12 | 10.1021/jm200999f | |||
| 6518655 | 108863 | None | 4 | Human | Functional | pIC50 | = | 5.8 | 5.8 | 2 | 3 | ChEMBL | 528 | 7 | 1 | 7 | 5.5 | COc1ccc(/N=C2\S/C(=C\c3ccc(N4CCOCC4)o3)C(=O)N2CCc2c[nH]c3ccccc23)cc1 | nan | |||
| CHEMBL3209511 | 108863 | None | 4 | Human | Functional | pIC50 | = | 5.8 | 5.8 | 2 | 3 | ChEMBL | 528 | 7 | 1 | 7 | 5.5 | COc1ccc(/N=C2\S/C(=C\c3ccc(N4CCOCC4)o3)C(=O)N2CCc2c[nH]c3ccccc23)cc1 | nan | |||
| 154634327 | 184845 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 380 | 2 | 2 | 6 | 2.1 | O=C(O)c1cc2cc3cc(C(=O)O)c(=O)oc3c(Br)c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4850743 | 184845 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 380 | 2 | 2 | 6 | 2.1 | O=C(O)c1cc2cc3cc(C(=O)O)c(=O)oc3c(Br)c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 154634324 | 185817 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 384 | 3 | 2 | 7 | 3.0 | O=C(O)c1cc2c(oc1=O)c(-c1cccs1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4865638 | 185817 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 384 | 3 | 2 | 7 | 3.0 | O=C(O)c1cc2c(oc1=O)c(-c1cccs1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 164627011 | 186512 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 350 | 2 | 2 | 4 | 3.8 | Cc1c2nc(C(=O)O)cc(Cl)c2cc2c(Cl)cc(C(=O)O)nc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4876009 | 186512 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 350 | 2 | 2 | 4 | 3.8 | Cc1c2nc(C(=O)O)cc(Cl)c2cc2c(Cl)cc(C(=O)O)nc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634326 | 185198 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 404 | 2 | 2 | 8 | 1.5 | O=C(O)c1cc2c(oc1=O)c(Br)cc1cc(-c3nnn[nH]3)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4856029 | 185198 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 404 | 2 | 2 | 8 | 1.5 | O=C(O)c1cc2c(oc1=O)c(Br)cc1cc(-c3nnn[nH]3)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 150386356 | 185252 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 312 | 3 | 2 | 5 | 2.9 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3cc2O)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4856916 | 185252 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 312 | 3 | 2 | 5 | 2.9 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3cc2O)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 1382708 | 29872 | None | 8 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 426 | 7 | 2 | 5 | 4.6 | O=C(CCCN1C(=O)S/C(=C/c2ccccc2)C1=S)Nc1ccc(C(=O)O)cc1 | nan | |||
| CHEMBL1387749 | 29872 | None | 8 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 426 | 7 | 2 | 5 | 4.6 | O=C(CCCN1C(=O)S/C(=C/c2ccccc2)C1=S)Nc1ccc(C(=O)O)cc1 | nan | |||
| 2885134 | 44453 | None | 7 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 373 | 6 | 2 | 5 | 5.0 | CCOc1ccc2nc3cc(NCc4ccc(OC)cc4)ccc3c(N)c2c1 | nan | |||
| CHEMBL1518827 | 44453 | None | 7 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 373 | 6 | 2 | 5 | 5.0 | CCOc1ccc2nc3cc(NCc4ccc(OC)cc4)ccc3c(N)c2c1 | nan | |||
| 45917986 | 59373 | None | 4 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -6 | 2 | ChEMBL | 314 | 2 | 0 | 4 | 4.4 | Cc1ccc(-c2nnc(C)c3nn(-c4ccc(C)cc4)cc23)cc1 | nan | |||
| CHEMBL1707517 | 59373 | None | 4 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -6 | 2 | ChEMBL | 314 | 2 | 0 | 4 | 4.4 | Cc1ccc(-c2nnc(C)c3nn(-c4ccc(C)cc4)cc23)cc1 | nan | |||
| 2286888 | 41093 | None | 6 | Human | Functional | pIC50 | = | 5.8 | 5.8 | 11 | 2 | ChEMBL | 466 | 8 | 2 | 5 | 5.0 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)cc2)C1=O)=C\c1ccccc1 | nan | |||
| CHEMBL1487870 | 41093 | None | 6 | Human | Functional | pIC50 | = | 5.8 | 5.8 | 11 | 2 | ChEMBL | 466 | 8 | 2 | 5 | 5.0 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)cc2)C1=O)=C\c1ccccc1 | nan | |||
| 2247463 | 27601 | None | 6 | Human | Functional | pIC50 | = | 5.8 | 5.8 | 15 | 2 | ChEMBL | 515 | 8 | 3 | 7 | 4.6 | CCc1nnc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)/C=C/c3ccc(C(C)C)cc3)cc2)s1 | nan | |||
| CHEMBL1369492 | 27601 | None | 6 | Human | Functional | pIC50 | = | 5.8 | 5.8 | 15 | 2 | ChEMBL | 515 | 8 | 3 | 7 | 4.6 | CCc1nnc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)/C=C/c3ccc(C(C)C)cc3)cc2)s1 | nan | |||
| 154634328 | 185207 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 378 | 3 | 2 | 6 | 3.0 | O=C(O)c1cc2c(oc1=O)c(-c1ccccc1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4856069 | 185207 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 378 | 3 | 2 | 6 | 3.0 | O=C(O)c1cc2c(oc1=O)c(-c1ccccc1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 152727536 | 184593 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 288 | 2 | 2 | 5 | 2.9 | O=C(O)c1cc2cc(-c3cccs3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4847144 | 184593 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 288 | 2 | 2 | 5 | 2.9 | O=C(O)c1cc2cc(-c3cccs3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 145954149 | 162694 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 361 | 3 | 2 | 4 | 3.0 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(F)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4169062 | 162694 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 361 | 3 | 2 | 4 | 3.0 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(F)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 2745687 | 933 | None | 27 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 10 | 3 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | nan | |||
| 9741 | 933 | None | 27 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 10 | 3 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | nan | |||
| CHEMBL1708510 | 933 | None | 27 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 10 | 3 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | nan | |||
| 8072340 | 55858 | None | 4 | Human | Functional | pIC50 | = | 5.8 | 5.8 | -1 | 2 | ChEMBL | 263 | 2 | 1 | 0 | 3.8 | Cc1ccc2[nH]c(C)c(/C=C/c3cc[n+](C)cc3)c2c1 | nan | |||
| CHEMBL1517609 | 55858 | None | 4 | Human | Functional | pIC50 | = | 5.8 | 5.8 | -1 | 2 | ChEMBL | 263 | 2 | 1 | 0 | 3.8 | Cc1ccc2[nH]c(C)c(/C=C/c3cc[n+](C)cc3)c2c1 | nan | |||
| CHEMBL1623159 | 55858 | None | 4 | Human | Functional | pIC50 | = | 5.8 | 5.8 | -1 | 2 | ChEMBL | 263 | 2 | 1 | 0 | 3.8 | Cc1ccc2[nH]c(C)c(/C=C/c3cc[n+](C)cc3)c2c1 | nan | |||
| 1205881 | 36175 | None | 2 | Human | Functional | pIC50 | = | 5.8 | 5.8 | 23 | 2 | ChEMBL | 426 | 7 | 2 | 5 | 4.0 | O=C(CCCN1C(=O)/C(=C\c2ccccc2)SC1=S)Nc1cccc(C(=O)O)c1 | nan | |||
| CHEMBL1444708 | 36175 | None | 2 | Human | Functional | pIC50 | = | 5.8 | 5.8 | 23 | 2 | ChEMBL | 426 | 7 | 2 | 5 | 4.0 | O=C(CCCN1C(=O)/C(=C\c2ccccc2)SC1=S)Nc1cccc(C(=O)O)c1 | nan | |||
| 21337669 | 68085 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 239 | 0 | 0 | 4 | 2.9 | CC1=C(C#N)C(=C(C#N)C#N)OC12CCCCC2 | 10.1021/jm200999f | |||
| CHEMBL1914582 | 68085 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 239 | 0 | 0 | 4 | 2.9 | CC1=C(C#N)C(=C(C#N)C#N)OC12CCCCC2 | 10.1021/jm200999f | |||
| 1231538 | 27526 | None | 29 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1 | 3 | ChEMBL | 523 | 6 | 1 | 6 | 6.0 | O=C(Nc1ccc2nc(SCc3ccc(Cl)cc3)sc2c1)c1ccccc1C(=O)N1CCOCC1 | nan | |||
| CHEMBL1368962 | 27526 | None | 29 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1 | 3 | ChEMBL | 523 | 6 | 1 | 6 | 6.0 | O=C(Nc1ccc2nc(SCc3ccc(Cl)cc3)sc2c1)c1ccccc1C(=O)N1CCOCC1 | nan | |||
| 3596034 | 42343 | None | 4 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 308 | 2 | 0 | 4 | 3.0 | CCN1CCN(C2=CC3=CC(=C(C#N)C#N)CCC3CC2)CC1 | nan | |||
| CHEMBL1498210 | 42343 | None | 4 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 308 | 2 | 0 | 4 | 3.0 | CCN1CCN(C2=CC3=CC(=C(C#N)C#N)CCC3CC2)CC1 | nan | |||
| 9581010 | 59198 | None | 3 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 449 | 5 | 2 | 6 | 3.9 | COC(=O)c1cnn(-c2ccc(F)cc2F)c1/C=N/NC(=S)Nc1ccc(Cl)cc1 | nan | |||
| CHEMBL1700467 | 59198 | None | 3 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 449 | 5 | 2 | 6 | 3.9 | COC(=O)c1cnn(-c2ccc(F)cc2F)c1/C=N/NC(=S)Nc1ccc(Cl)cc1 | nan | |||
| 154634337 | 185439 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1cccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4859764 | 185439 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1cccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| 145971743 | 163199 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 361 | 3 | 2 | 4 | 3.0 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccccc1F | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4177096 | 163199 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 361 | 3 | 2 | 4 | 3.0 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccccc1F | 10.1021/acsmedchemlett.7b00510 | |||
| 9581010 | 59198 | None | 3 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 449 | 5 | 2 | 6 | 3.9 | COC(=O)c1cnn(-c2ccc(F)cc2F)c1/C=N/NC(=S)Nc1ccc(Cl)cc1 | nan | |||
| CHEMBL1700467 | 59198 | None | 3 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 449 | 5 | 2 | 6 | 3.9 | COC(=O)c1cnn(-c2ccc(F)cc2F)c1/C=N/NC(=S)Nc1ccc(Cl)cc1 | nan | |||
| 152684818 | 185098 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 312 | 3 | 2 | 5 | 2.9 | COc1ccccc1-c1cc2cc(C(=O)O)c(=O)oc2cc1O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4854346 | 185098 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 312 | 3 | 2 | 5 | 2.9 | COc1ccccc1-c1cc2cc(C(=O)O)c(=O)oc2cc1O | 10.1021/acs.jmedchem.0c01624 | |||
| 21157241 | 71905 | None | 3 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 381 | 5 | 1 | 5 | 2.3 | COc1ccc(/C=c2\s/c(=C/C(=O)c3ccc(C)cc3)[nH]c2=O)c(OC)c1 | nan | |||
| CHEMBL1970711 | 71905 | None | 3 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 381 | 5 | 1 | 5 | 2.3 | COc1ccc(/C=c2\s/c(=C/C(=O)c3ccc(C)cc3)[nH]c2=O)c(OC)c1 | nan | |||
| 1502520 | 34510 | None | 16 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -9 | 2 | ChEMBL | 398 | 4 | 0 | 6 | 3.8 | Cc1ccc(Cn2ncc3c(N4CCN(c5ccccc5C)CC4)ncnc32)cc1 | nan | |||
| CHEMBL1428840 | 34510 | None | 16 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -9 | 2 | ChEMBL | 398 | 4 | 0 | 6 | 3.8 | Cc1ccc(Cn2ncc3c(N4CCN(c5ccccc5C)CC4)ncnc32)cc1 | nan | |||
| 15945506 | 48035 | None | 5 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 417 | 5 | 1 | 4 | 5.8 | CC(=O)c1ccc(NC(=O)C(C)n2nc(-c3ccccc3)c3cc(Cl)ccc32)cc1 | nan | |||
| CHEMBL1550295 | 48035 | None | 5 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 417 | 5 | 1 | 4 | 5.8 | CC(=O)c1ccc(NC(=O)C(C)n2nc(-c3ccccc3)c3cc(Cl)ccc32)cc1 | nan | |||
| 154634326 | 185198 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 404 | 2 | 2 | 8 | 1.5 | O=C(O)c1cc2c(oc1=O)c(Br)cc1cc(-c3nnn[nH]3)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4856029 | 185198 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 404 | 2 | 2 | 8 | 1.5 | O=C(O)c1cc2c(oc1=O)c(Br)cc1cc(-c3nnn[nH]3)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634321 | 186103 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2c3oc(=O)c(C(=O)O)cc3cc3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4870213 | 186103 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2c3oc(=O)c(C(=O)O)cc3cc3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 152243845 | 185005 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 324 | 3 | 2 | 4 | 4.0 | CC(C)c1ccc(-c2cc3cc(C(=O)O)c(=O)oc3cc2O)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4853043 | 185005 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 324 | 3 | 2 | 4 | 4.0 | CC(C)c1ccc(-c2cc3cc(C(=O)O)c(=O)oc3cc2O)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 2770749 | 56045 | None | 1 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 1 | 3 | ChEMBL | 281 | 4 | 0 | 1 | 3.9 | CN(C)/C=C/C=C/C=C/C1=[N+](C)c2ccccc2C1(C)C | nan | |||
| 5708223 | 56045 | None | 1 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 1 | 3 | ChEMBL | 281 | 4 | 0 | 1 | 3.9 | CN(C)/C=C/C=C/C=C/C1=[N+](C)c2ccccc2C1(C)C | nan | |||
| 5830170 | 56045 | None | 1 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 1 | 3 | ChEMBL | 281 | 4 | 0 | 1 | 3.9 | CN(C)/C=C/C=C/C=C/C1=[N+](C)c2ccccc2C1(C)C | nan | |||
| CHEMBL1572785 | 56045 | None | 1 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 1 | 3 | ChEMBL | 281 | 4 | 0 | 1 | 3.9 | CN(C)/C=C/C=C/C=C/C1=[N+](C)c2ccccc2C1(C)C | nan | |||
| CHEMBL1624721 | 56045 | None | 1 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 1 | 3 | ChEMBL | 281 | 4 | 0 | 1 | 3.9 | CN(C)/C=C/C=C/C=C/C1=[N+](C)c2ccccc2C1(C)C | nan | |||
| 53258796 | 68094 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 444 | 13 | 1 | 3 | 8.3 | CCCCCCCCCCCCCc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| CHEMBL1914591 | 68094 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 444 | 13 | 1 | 3 | 8.3 | CCCCCCCCCCCCCc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| 2277094 | 49030 | None | 6 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 470 | 7 | 2 | 7 | 3.7 | O=C(CCCN1C(=O)/C(=C/c2ccc3c(c2)OCO3)SC1=S)Nc1cccc(C(=O)O)c1 | nan | |||
| CHEMBL1560901 | 49030 | None | 6 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 470 | 7 | 2 | 7 | 3.7 | O=C(CCCN1C(=O)/C(=C/c2ccc3c(c2)OCO3)SC1=S)Nc1cccc(C(=O)O)c1 | nan | |||
| 11674067 | 68081 | None | 27 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 315 | 1 | 0 | 4 | 3.6 | CC1=C(C#N)C(=C(C#N)C#N)OC1(c1ccccc1)C(F)(F)F | 10.1021/jm200999f | |||
| CHEMBL1914578 | 68081 | None | 27 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 315 | 1 | 0 | 4 | 3.6 | CC1=C(C#N)C(=C(C#N)C#N)OC1(c1ccccc1)C(F)(F)F | 10.1021/jm200999f | |||
| 2526579 | 54783 | None | 1 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 423 | 12 | 1 | 7 | 5.0 | CCN(CC)CCCNc1ccc(-c2nnc(-c3ccc(OCC(C)C)cc3)o2)cn1 | nan | |||
| CHEMBL1612267 | 54783 | None | 1 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 423 | 12 | 1 | 7 | 5.0 | CCN(CC)CCCNc1ccc(-c2nnc(-c3ccc(OCC(C)C)cc3)o2)cn1 | nan | |||
| 6489901 | 56179 | None | 1 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 1 | 2 | ChEMBL | 289 | 4 | 0 | 1 | 4.1 | C=CCn1c(C)c(/C=C/c2cc[n+](C)cc2)c2ccccc21 | nan | |||
| CHEMBL1576905 | 56179 | None | 1 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 1 | 2 | ChEMBL | 289 | 4 | 0 | 1 | 4.1 | C=CCn1c(C)c(/C=C/c2cc[n+](C)cc2)c2ccccc21 | nan | |||
| CHEMBL1626041 | 56179 | None | 1 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 1 | 2 | ChEMBL | 289 | 4 | 0 | 1 | 4.1 | C=CCn1c(C)c(/C=C/c2cc[n+](C)cc2)c2ccccc21 | nan | |||
| 326869 | 112874 | None | 2 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 314 | 2 | 4 | 4 | 1.1 | Cc1c2[nH]c(C(=O)O)cc(=O)c2cc2c(=O)cc(C(=O)O)[nH]c12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL3306990 | 112874 | None | 2 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 314 | 2 | 4 | 4 | 1.1 | Cc1c2[nH]c(C(=O)O)cc(=O)c2cc2c(=O)cc(C(=O)O)[nH]c12 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634321 | 186103 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2c3oc(=O)c(C(=O)O)cc3cc3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4870213 | 186103 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2c3oc(=O)c(C(=O)O)cc3cc3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634332 | 185233 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4856506 | 185233 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 68324914 | 185837 | None | 34 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 284 | 2 | 2 | 5 | 3.6 | O=C(O)c1cc2sc3cc(C(=O)O)sc3c2s1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4865971 | 185837 | None | 34 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 284 | 2 | 2 | 5 | 3.6 | O=C(O)c1cc2sc3cc(C(=O)O)sc3c2s1 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634328 | 185207 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 378 | 3 | 2 | 6 | 3.0 | O=C(O)c1cc2c(oc1=O)c(-c1ccccc1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4856069 | 185207 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 378 | 3 | 2 | 6 | 3.0 | O=C(O)c1cc2c(oc1=O)c(-c1ccccc1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 145958495 | 162292 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 349 | 3 | 2 | 4 | 3.1 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)C1CCCCC1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4162653 | 162292 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 349 | 3 | 2 | 4 | 3.1 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)C1CCCCC1 | 10.1021/acsmedchemlett.7b00510 | |||
| 150149078 | 186450 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 282 | 2 | 2 | 4 | 2.9 | O=C(O)c1cc2cc(-c3ccccc3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4875041 | 186450 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 282 | 2 | 2 | 4 | 2.9 | O=C(O)c1cc2cc(-c3ccccc3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 5144920 | 21355 | None | 2 | Human | Functional | pIC50 | = | 4.7 | 4.7 | 1 | 2 | ChEMBL | 424 | 3 | 1 | 7 | 4.3 | Cc1c(C(=O)Nc2ccc3c(c2)OCCO3)sc2ncnc(N3CCC(C)CC3)c12 | nan | |||
| CHEMBL1314099 | 21355 | None | 2 | Human | Functional | pIC50 | = | 4.7 | 4.7 | 1 | 2 | ChEMBL | 424 | 3 | 1 | 7 | 4.3 | Cc1c(C(=O)Nc2ccc3c(c2)OCCO3)sc2ncnc(N3CCC(C)CC3)c12 | nan | |||
| 4557537 | 38109 | None | 2 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 424 | 3 | 1 | 7 | 4.3 | Cc1nc(N2CCCCC2)c2c(C)c(C(=O)Nc3ccc4c(c3)OCCO4)sc2n1 | nan | |||
| CHEMBL1460894 | 38109 | None | 2 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 424 | 3 | 1 | 7 | 4.3 | Cc1nc(N2CCCCC2)c2c(C)c(C(=O)Nc3ccc4c(c3)OCCO4)sc2n1 | nan | |||
| 91754 | 85284 | None | 43 | Human | Functional | pIC50 | = | 6.7 | 6.7 | -31 | 3 | ChEMBL | 364 | 3 | 0 | 4 | 5.2 | CC(C)(C)c1ccc(CSc2cnn(C(C)(C)C)c(=O)c2Cl)cc1 | 10.6019/CHEMBL5442687 | |||
| CHEMBL225963 | 85284 | None | 43 | Human | Functional | pIC50 | = | 6.7 | 6.7 | -31 | 3 | ChEMBL | 364 | 3 | 0 | 4 | 5.2 | CC(C)(C)c1ccc(CSc2cnn(C(C)(C)C)c(=O)c2Cl)cc1 | 10.6019/CHEMBL5442687 | |||
| 6203183 | 52368 | None | 5 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 486 | 7 | 3 | 8 | 3.4 | O=C(CCCN1C(=O)/C(=C/c2ccc3c(c2)OCO3)SC1=S)Nc1ccc(C(=O)O)c(O)c1 | nan | |||
| CHEMBL1589711 | 52368 | None | 5 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 486 | 7 | 3 | 8 | 3.4 | O=C(CCCN1C(=O)/C(=C/c2ccc3c(c2)OCO3)SC1=S)Nc1ccc(C(=O)O)c(O)c1 | nan | |||
| 6876400 | 73014 | None | 5 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 3 | 2 | ChEMBL | 448 | 8 | 2 | 6 | 5.0 | CCOc1ccc(/C=N/NC(=O)Cc2csc(Nc3cccc(C(F)(F)F)c3)n2)cc1 | nan | |||
| CHEMBL2007593 | 73014 | None | 5 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 3 | 2 | ChEMBL | 448 | 8 | 2 | 6 | 5.0 | CCOc1ccc(/C=N/NC(=O)Cc2csc(Nc3cccc(C(F)(F)F)c3)n2)cc1 | nan | |||
| 154634324 | 185817 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 384 | 3 | 2 | 7 | 3.0 | O=C(O)c1cc2c(oc1=O)c(-c1cccs1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4865638 | 185817 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 384 | 3 | 2 | 7 | 3.0 | O=C(O)c1cc2c(oc1=O)c(-c1cccs1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 145958540 | 162364 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(Cl)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4163894 | 162364 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(Cl)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 145952912 | 162539 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 361 | 3 | 2 | 4 | 3.0 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccc(F)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4166473 | 162539 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 361 | 3 | 2 | 4 | 3.0 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccc(F)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| 9581015 | 59417 | None | 3 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 413 | 5 | 2 | 6 | 3.6 | COC(=O)c1cnn(-c2ccc(Cl)cc2)c1/C=N/NC(=S)Nc1ccccc1 | nan | |||
| CHEMBL1709632 | 59417 | None | 3 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 413 | 5 | 2 | 6 | 3.6 | COC(=O)c1cnn(-c2ccc(Cl)cc2)c1/C=N/NC(=S)Nc1ccccc1 | nan | |||
| 3243122 | 46418 | None | 4 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 421 | 3 | 0 | 5 | 4.6 | COc1ccc2nc3oc(C(=O)N4CCN(c5cccc(Cl)c5)CC4)cc3cc2c1 | nan | |||
| CHEMBL1536710 | 46418 | None | 4 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 421 | 3 | 0 | 5 | 4.6 | COc1ccc2nc3oc(C(=O)N4CCN(c5cccc(Cl)c5)CC4)cc3cc2c1 | nan | |||
| 5731274 | 52366 | None | 6 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 468 | 8 | 1 | 6 | 4.8 | CCOC(=O)c1ccc(NC(=O)CCCN2C(=O)/C(=C/c3ccc(C)cc3)SC2=S)cc1 | nan | |||
| CHEMBL1589694 | 52366 | None | 6 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 468 | 8 | 1 | 6 | 4.8 | CCOC(=O)c1ccc(NC(=O)CCCN2C(=O)/C(=C/c3ccc(C)cc3)SC2=S)cc1 | nan | |||
| 21337670 | 68082 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 321 | 0 | 0 | 4 | 4.1 | CC1=C(C#N)C(=C(C#N)C#N)OC12c1ccccc1-c1ccccc12 | 10.1021/jm200999f | |||
| CHEMBL1914579 | 68082 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 321 | 0 | 0 | 4 | 4.1 | CC1=C(C#N)C(=C(C#N)C#N)OC12c1ccccc1-c1ccccc12 | 10.1021/jm200999f | |||
| 8108341 | 37640 | None | 3 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 364 | 7 | 1 | 3 | 5.1 | O=C(O)COc1ccc(/C=C/C(=O)c2ccc(C3CCCCC3)cc2)cc1 | nan | |||
| CHEMBL1457048 | 37640 | None | 3 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 364 | 7 | 1 | 3 | 5.1 | O=C(O)COc1ccc(/C=C/C(=O)c2ccc(C3CCCCC3)cc2)cc1 | nan | |||
| 720233 | 50205 | None | 37 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 2 | 2 | ChEMBL | 288 | 2 | 0 | 3 | 3.3 | O=c1c(Cl)c(Cl)cnn1Cc1ccccc1Cl | nan | |||
| CHEMBL1570760 | 50205 | None | 37 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 2 | 2 | ChEMBL | 288 | 2 | 0 | 3 | 3.3 | O=c1c(Cl)c(Cl)cnn1Cc1ccccc1Cl | nan | |||
| 9581015 | 59417 | None | 3 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 413 | 5 | 2 | 6 | 3.6 | COC(=O)c1cnn(-c2ccc(Cl)cc2)c1/C=N/NC(=S)Nc1ccccc1 | nan | |||
| CHEMBL1709632 | 59417 | None | 3 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 413 | 5 | 2 | 6 | 3.6 | COC(=O)c1cnn(-c2ccc(Cl)cc2)c1/C=N/NC(=S)Nc1ccccc1 | nan | |||
| 154634314 | 186715 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccccc1-c1cc2cc(C(=O)O)c(=O)oc2c2cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4878979 | 186715 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccccc1-c1cc2cc(C(=O)O)c(=O)oc2c2cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 3420390 | 178715 | None | 3 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 474 | 8 | 2 | 5 | 1.6 | NS(=O)(=O)c1ccc(CCNC(=O)CCS(=O)(=O)c2ccc(Br)cc2)cc1 | nan | |||
| CHEMBL467373 | 178715 | None | 3 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 474 | 8 | 2 | 5 | 1.6 | NS(=O)(=O)c1ccc(CCNC(=O)CCS(=O)(=O)c2ccc(Br)cc2)cc1 | nan | |||
| 151577785 | 186659 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 312 | 3 | 2 | 5 | 2.9 | COc1cccc(-c2cc3cc(C(=O)O)c(=O)oc3cc2O)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4878047 | 186659 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 312 | 3 | 2 | 5 | 2.9 | COc1cccc(-c2cc3cc(C(=O)O)c(=O)oc3cc2O)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| 5513575 | 42741 | None | 5 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 441 | 4 | 2 | 5 | 4.9 | N=C1/C(=C\c2ccc(-c3cccc(C(=O)O)c3)o2)C(=O)N=C2SC=C(c3ccccc3)N12 | nan | |||
| CHEMBL1501743 | 42741 | None | 5 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 441 | 4 | 2 | 5 | 4.9 | N=C1/C(=C\c2ccc(-c3cccc(C(=O)O)c3)o2)C(=O)N=C2SC=C(c3ccccc3)N12 | nan | |||
| 9581008 | 59565 | None | 3 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 353 | 4 | 2 | 6 | 1.4 | CNC(=S)N/N=C/c1c(C(=O)OC)cnn1-c1ccc(F)cc1F | nan | |||
| CHEMBL1716874 | 59565 | None | 3 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 353 | 4 | 2 | 6 | 1.4 | CNC(=S)N/N=C/c1c(C(=O)OC)cnn1-c1ccc(F)cc1F | nan | |||
| 4623233 | 60067 | None | 4 | Human | Functional | pIC50 | = | 4.6 | 4.6 | -12 | 3 | ChEMBL | 320 | 2 | 0 | 4 | 4.4 | Cc1nnc(-c2ccccc2)c2cn(-c3ccc(Cl)cc3)nc12 | nan | |||
| CHEMBL1736438 | 60067 | None | 4 | Human | Functional | pIC50 | = | 4.6 | 4.6 | -12 | 3 | ChEMBL | 320 | 2 | 0 | 4 | 4.4 | Cc1nnc(-c2ccccc2)c2cn(-c3ccc(Cl)cc3)nc12 | nan | |||
| 16193843 | 46093 | None | 4 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 412 | 3 | 1 | 7 | 3.8 | CC(C)CSC1=NSC2=NC(=O)/C(=C\c3coc4ccccc4c3=O)C(=N)N12 | nan | |||
| CHEMBL1533415 | 46093 | None | 4 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 412 | 3 | 1 | 7 | 3.8 | CC(C)CSC1=NSC2=NC(=O)/C(=C\c3coc4ccccc4c3=O)C(=N)N12 | nan | |||
| 2286812 | 29474 | None | 32 | Human | Functional | pIC50 | = | 5.6 | 5.6 | 16 | 2 | ChEMBL | 482 | 8 | 3 | 6 | 4.7 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)c(O)c2)C1=O)=C\c1ccccc1 | nan | |||
| CHEMBL1384502 | 29474 | None | 32 | Human | Functional | pIC50 | = | 5.6 | 5.6 | 16 | 2 | ChEMBL | 482 | 8 | 3 | 6 | 4.7 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)c(O)c2)C1=O)=C\c1ccccc1 | nan | |||
| 5768597 | 20778 | None | 3 | Human | Functional | pIC50 | = | 5.6 | 5.6 | 3 | 2 | ChEMBL | 320 | 3 | 1 | 5 | 3.1 | N#C/C(=C/c1ccc(N2CCOCC2)o1)c1nc2ccccc2[nH]1 | nan | |||
| CHEMBL1309475 | 20778 | None | 3 | Human | Functional | pIC50 | = | 5.6 | 5.6 | 3 | 2 | ChEMBL | 320 | 3 | 1 | 5 | 3.1 | N#C/C(=C/c1ccc(N2CCOCC2)o1)c1nc2ccccc2[nH]1 | nan | |||
| 12005127 | 44820 | None | 3 | Human | Functional | pIC50 | = | 5.6 | 5.6 | -3 | 4 | ChEMBL | 333 | 6 | 0 | 4 | 4.6 | COc1cc(/C=C(/C)[N+](=O)[O-])ccc1OCc1ccccc1Cl | nan | |||
| CHEMBL1521989 | 44820 | None | 3 | Human | Functional | pIC50 | = | 5.6 | 5.6 | -3 | 4 | ChEMBL | 333 | 6 | 0 | 4 | 4.6 | COc1cc(/C=C(/C)[N+](=O)[O-])ccc1OCc1ccccc1Cl | nan | |||
| 9581008 | 59565 | None | 3 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 353 | 4 | 2 | 6 | 1.4 | CNC(=S)N/N=C/c1c(C(=O)OC)cnn1-c1ccc(F)cc1F | nan | |||
| CHEMBL1716874 | 59565 | None | 3 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 353 | 4 | 2 | 6 | 1.4 | CNC(=S)N/N=C/c1c(C(=O)OC)cnn1-c1ccc(F)cc1F | nan | |||
| 154634318 | 186105 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 318 | 2 | 3 | 7 | 1.0 | O=C(O)c1cc2cc3cc(C(=O)O)c(=O)oc3c(O)c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4870255 | 186105 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 318 | 2 | 3 | 7 | 1.0 | O=C(O)c1cc2cc3cc(C(=O)O)c(=O)oc3c(O)c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 164627011 | 186512 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 350 | 2 | 2 | 4 | 3.8 | Cc1c2nc(C(=O)O)cc(Cl)c2cc2c(Cl)cc(C(=O)O)nc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4876009 | 186512 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 350 | 2 | 2 | 4 | 3.8 | Cc1c2nc(C(=O)O)cc(Cl)c2cc2c(Cl)cc(C(=O)O)nc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 1346847 | 21208 | None | 6 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 412 | 6 | 2 | 5 | 4.3 | Cc1ccc(/C=C2\SC(=S)N(CCCC(=O)Nc3ccc(O)cc3)C2=O)cc1 | nan | |||
| CHEMBL1312928 | 21208 | None | 6 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 412 | 6 | 2 | 5 | 4.3 | Cc1ccc(/C=C2\SC(=S)N(CCCC(=O)Nc3ccc(O)cc3)C2=O)cc1 | nan | |||
| 154634322 | 185486 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 307 | 1 | 1 | 8 | 1.0 | N#Cc1cc2c(ccc3cc(-c4nnn[nH]4)c(=O)oc32)oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4860550 | 185486 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 307 | 1 | 1 | 8 | 1.0 | N#Cc1cc2c(ccc3cc(-c4nnn[nH]4)c(=O)oc32)oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 6109309 | 29989 | None | 1 | Human | Functional | pIC50 | = | 5.6 | 5.6 | 3 | 3 | ChEMBL | 355 | 5 | 1 | 4 | 4.0 | CC(NC(=O)/C(C#N)=C/c1ccc(Cl)c([N+](=O)[O-])c1)c1ccccc1 | nan | |||
| CHEMBL1388639 | 29989 | None | 1 | Human | Functional | pIC50 | = | 5.6 | 5.6 | 3 | 3 | ChEMBL | 355 | 5 | 1 | 4 | 4.0 | CC(NC(=O)/C(C#N)=C/c1ccc(Cl)c([N+](=O)[O-])c1)c1ccccc1 | nan | |||
| 6622007 | 39053 | None | 4 | Human | Functional | pIC50 | = | 4.6 | 4.6 | -9 | 4 | ChEMBL | 489 | 3 | 2 | 7 | 4.6 | CC(C)(C)OC(=O)N1CCC(c2cc(O)n3ncc(C(=O)Nc4ccc(F)c(Cl)c4)c3n2)CC1 | nan | |||
| CHEMBL1468612 | 39053 | None | 4 | Human | Functional | pIC50 | = | 4.6 | 4.6 | -9 | 4 | ChEMBL | 489 | 3 | 2 | 7 | 4.6 | CC(C)(C)OC(=O)N1CCC(c2cc(O)n3ncc(C(=O)Nc4ccc(F)c(Cl)c4)c3n2)CC1 | nan | |||
| 4798059 | 31933 | None | 7 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 296 | 4 | 1 | 3 | 4.3 | COc1ccc2nc(C)cc(NCc3ccc(F)cc3)c2c1 | nan | |||
| CHEMBL1407436 | 31933 | None | 7 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 296 | 4 | 1 | 3 | 4.3 | COc1ccc2nc(C)cc(NCc3ccc(F)cc3)c2c1 | nan | |||
| 154634335 | 184589 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1cccc(-c2c3oc(=O)c(C(=O)O)cc3cc3cc(C(=O)O)c(=O)oc23)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4847100 | 184589 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1cccc(-c2c3oc(=O)c(C(=O)O)cc3cc3cc(C(=O)O)c(=O)oc23)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634323 | 184710 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 380 | 2 | 2 | 6 | 2.1 | O=C(O)c1cc2c(oc1=O)c(Br)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4848949 | 184710 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 380 | 2 | 2 | 6 | 2.1 | O=C(O)c1cc2c(oc1=O)c(Br)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 145971442 | 163122 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4175848 | 163122 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 145953203 | 162633 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 403 | 5 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)cc1OC | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4167991 | 162633 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 403 | 5 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)cc1OC | 10.1021/acsmedchemlett.7b00510 | |||
| 145955027 | 162635 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 349 | 3 | 2 | 5 | 2.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccs1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4168042 | 162635 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 349 | 3 | 2 | 5 | 2.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccs1 | 10.1021/acsmedchemlett.7b00510 | |||
| 6226024 | 45683 | None | 4 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 442 | 7 | 3 | 6 | 3.7 | O=C(CCCN1C(=O)/C(=C/c2ccccc2)SC1=S)Nc1ccc(C(=O)O)c(O)c1 | nan | |||
| CHEMBL1529781 | 45683 | None | 4 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 442 | 7 | 3 | 6 | 3.7 | O=C(CCCN1C(=O)/C(=C/c2ccccc2)SC1=S)Nc1ccc(C(=O)O)c(O)c1 | nan | |||
| 154634336 | 186174 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccccc1-c1c2oc(=O)c(C(=O)O)cc2cc2cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4871203 | 186174 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccccc1-c1c2oc(=O)c(C(=O)O)cc2cc2cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634316 | 186448 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 426 | 4 | 2 | 7 | 3.1 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)c(F)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4875009 | 186448 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 426 | 4 | 2 | 7 | 3.1 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)c(F)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| 759209 | 35980 | None | 10 | Human | Functional | pIC50 | = | 5.6 | 5.6 | -1 | 4 | ChEMBL | 259 | 1 | 0 | 3 | 3.5 | Cc1c(Cl)sn(-c2ccc(Cl)cc2)c1=O | nan | |||
| CHEMBL1442788 | 35980 | None | 10 | Human | Functional | pIC50 | = | 5.6 | 5.6 | -1 | 4 | ChEMBL | 259 | 1 | 0 | 3 | 3.5 | Cc1c(Cl)sn(-c2ccc(Cl)cc2)c1=O | nan | |||
| 648447 | 38811 | None | 3 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 375 | 3 | 1 | 7 | 2.1 | COc1cccc(C2C3CN(C)CC=C3C(C#N)=C(N)C2(C#N)C#N)c1OC | nan | |||
| CHEMBL1466582 | 38811 | None | 3 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 375 | 3 | 1 | 7 | 2.1 | COc1cccc(C2C3CN(C)CC=C3C(C#N)=C(N)C2(C#N)C#N)c1OC | nan | |||
| 1527596 | 43102 | None | 6 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 448 | 7 | 2 | 7 | 4.9 | CCOC(=O)c1c(-c2ccccc2)csc1NC(=O)/C(C#N)=C/c1ccc(O)c(OC)c1 | nan | |||
| CHEMBL1504949 | 43102 | None | 6 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 448 | 7 | 2 | 7 | 4.9 | CCOC(=O)c1c(-c2ccccc2)csc1NC(=O)/C(C#N)=C/c1ccc(O)c(OC)c1 | nan | |||
| 4406525 | 38445 | None | 3 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 294 | 1 | 0 | 4 | 2.6 | CN1CCN(C2=CC3=CC(=C(C#N)C#N)CCC3CC2)CC1 | nan | |||
| CHEMBL1463795 | 38445 | None | 3 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 294 | 1 | 0 | 4 | 2.6 | CN1CCN(C2=CC3=CC(=C(C#N)C#N)CCC3CC2)CC1 | nan | |||
| 45489602 | 59293 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 295 | 4 | 2 | 5 | 2.1 | COc1ccc(C(=O)Nc2ccccc2-c2nn[nH]n2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL1704189 | 59293 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 295 | 4 | 2 | 5 | 2.1 | COc1ccc(C(=O)Nc2ccccc2-c2nn[nH]n2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 145971240 | 163182 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 309 | 3 | 2 | 4 | 2.2 | CC(C)C(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4176719 | 163182 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 309 | 3 | 2 | 4 | 2.2 | CC(C)C(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| 164610101 | 184981 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 342 | 4 | 2 | 6 | 2.5 | COc1cc(C(=O)O)nc2c(C)c3nc(C(=O)O)cc(OC)c3cc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4852667 | 184981 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 342 | 4 | 2 | 6 | 2.5 | COc1cc(C(=O)O)nc2c(C)c3nc(C(=O)O)cc(OC)c3cc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 1214651 | 59593 | None | 6 | Human | Functional | pIC50 | = | 4.6 | 4.6 | -42 | 4 | ChEMBL | 414 | 2 | 0 | 4 | 5.7 | Cc1nnc(-c2cccc3ccccc23)c2cn(-c3cccc(Br)c3)nc12 | nan | |||
| CHEMBL1718220 | 59593 | None | 6 | Human | Functional | pIC50 | = | 4.6 | 4.6 | -42 | 4 | ChEMBL | 414 | 2 | 0 | 4 | 5.7 | Cc1nnc(-c2cccc3ccccc23)c2cn(-c3cccc(Br)c3)nc12 | nan | |||
| 154634327 | 184845 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 380 | 2 | 2 | 6 | 2.1 | O=C(O)c1cc2cc3cc(C(=O)O)c(=O)oc3c(Br)c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4850743 | 184845 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 380 | 2 | 2 | 6 | 2.1 | O=C(O)c1cc2cc3cc(C(=O)O)c(=O)oc3c(Br)c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 6619478 | 25945 | None | 1 | Human | Functional | pIC50 | = | 4.5 | 4.5 | -9 | 2 | ChEMBL | 501 | 4 | 2 | 8 | 4.5 | COc1ccc(NC(=O)c2cnn3c(O)cc(C4CCN(C(=O)OC(C)(C)C)CC4)nc23)cc1Cl | nan | |||
| CHEMBL1354041 | 25945 | None | 1 | Human | Functional | pIC50 | = | 4.5 | 4.5 | -9 | 2 | ChEMBL | 501 | 4 | 2 | 8 | 4.5 | COc1ccc(NC(=O)c2cnn3c(O)cc(C4CCN(C(=O)OC(C)(C)C)CC4)nc23)cc1Cl | nan | |||
| 154634337 | 185439 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1cccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4859764 | 185439 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1cccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| 164627011 | 186512 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 350 | 2 | 2 | 4 | 3.8 | Cc1c2nc(C(=O)O)cc(Cl)c2cc2c(Cl)cc(C(=O)O)nc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4876009 | 186512 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 350 | 2 | 2 | 4 | 3.8 | Cc1c2nc(C(=O)O)cc(Cl)c2cc2c(Cl)cc(C(=O)O)nc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 1024 | 16495 | None | 63 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 330 | 3 | 4 | 6 | 0.6 | O=C(O)c1cc(C(=O)O)c2c(n1)C(=O)C(=O)c1cc(C(=O)O)[nH]c1-2 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL1235421 | 16495 | None | 63 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 330 | 3 | 4 | 6 | 0.6 | O=C(O)c1cc(C(=O)O)c2c(n1)C(=O)C(=O)c1cc(C(=O)O)[nH]c1-2 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634320 | 186716 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 302 | 2 | 2 | 6 | 1.3 | O=C(O)c1cc2c(ccc3cc(C(=O)O)c(=O)oc32)oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4879017 | 186716 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 302 | 2 | 2 | 6 | 1.3 | O=C(O)c1cc2c(ccc3cc(C(=O)O)c(=O)oc32)oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 154634331 | 184654 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 420 | 4 | 2 | 6 | 4.1 | CC(C)c1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4848109 | 184654 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 420 | 4 | 2 | 6 | 4.1 | CC(C)c1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 145952453 | 162883 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 343 | 3 | 2 | 4 | 2.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccccc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4172188 | 162883 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 343 | 3 | 2 | 4 | 2.9 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccccc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 14286542 | 72244 | None | 2 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -4 | 4 | ChEMBL | 401 | 2 | 3 | 4 | 2.9 | CC1=CC2/C=C(\C)CCC(O)C(O)/C=C/C(=O)C23C(=O)NC(CC(C)C)C3C1C | nan | |||
| CHEMBL1981103 | 72244 | None | 2 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -4 | 4 | ChEMBL | 401 | 2 | 3 | 4 | 2.9 | CC1=CC2/C=C(\C)CCC(O)C(O)/C=C/C(=O)C23C(=O)NC(CC(C)C)C3C1C | nan | |||
| 9581005 | 59650 | None | 1 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 21 | 2 | ChEMBL | 359 | 4 | 2 | 6 | 2.3 | COC(=O)c1cnn(-c2ccccc2)c1/C=N/NC(=S)NC(C)(C)C | nan | |||
| CHEMBL1720530 | 59650 | None | 1 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 21 | 2 | ChEMBL | 359 | 4 | 2 | 6 | 2.3 | COC(=O)c1cnn(-c2ccccc2)c1/C=N/NC(=S)NC(C)(C)C | nan | |||
| 135650717 | 108268 | None | 3 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -2 | 2 | ChEMBL | 374 | 4 | 3 | 6 | 4.3 | Oc1ccc(/C=N/Nc2nc(-c3ccccc3F)nc3ccccc23)c(O)c1 | nan | |||
| CHEMBL3196703 | 108268 | None | 3 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -2 | 2 | ChEMBL | 374 | 4 | 3 | 6 | 4.3 | Oc1ccc(/C=N/Nc2nc(-c3ccccc3F)nc3ccccc23)c(O)c1 | nan | |||
| 6226345 | 31153 | None | 5 | Human | Functional | pIC50 | = | 5.5 | 5.5 | 4 | 2 | ChEMBL | 353 | 5 | 3 | 4 | 2.9 | CCCCN1C(=O)NC(=O)/C(=C(O)\C=C\c2c[nH]c3ccccc23)C1=O | nan | |||
| CHEMBL1400236 | 31153 | None | 5 | Human | Functional | pIC50 | = | 5.5 | 5.5 | 4 | 2 | ChEMBL | 353 | 5 | 3 | 4 | 2.9 | CCCCN1C(=O)NC(=O)/C(=C(O)\C=C\c2c[nH]c3ccccc23)C1=O | nan | |||
| 6603703 | 208 | None | 8 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -1047 | 18 | ChEMBL | 329 | 2 | 3 | 4 | 3.3 | NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3 | 10.6019/CHEMBL5442687 | |||
| 9637 | 208 | None | 8 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -1047 | 18 | ChEMBL | 329 | 2 | 3 | 4 | 3.3 | NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3 | 10.6019/CHEMBL5442687 | |||
| CHEMBL291143 | 208 | None | 8 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -1047 | 18 | ChEMBL | 329 | 2 | 3 | 4 | 3.3 | NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3 | 10.6019/CHEMBL5442687 | |||
| 2868490 | 54333 | None | 8 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 354 | 3 | 0 | 3 | 5.6 | COc1ccc(C=C2C=C(C(C)(C)C)C(=O)C(C(C)(C)C)=C2)cc1OC | nan | |||
| CHEMBL1608333 | 54333 | None | 8 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 354 | 3 | 0 | 3 | 5.6 | COc1ccc(C=C2C=C(C(C)(C)C)C(=O)C(C(C)(C)C)=C2)cc1OC | nan | |||
| 9581007 | 59288 | None | 1 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 413 | 5 | 2 | 6 | 3.6 | COC(=O)c1cnn(-c2ccccc2)c1/C=N/NC(=S)Nc1ccc(Cl)cc1 | nan | |||
| CHEMBL1704074 | 59288 | None | 1 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 413 | 5 | 2 | 6 | 3.6 | COC(=O)c1cnn(-c2ccccc2)c1/C=N/NC(=S)Nc1ccc(Cl)cc1 | nan | |||
| 2286812 | 29474 | None | 32 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 16 | 2 | ChEMBL | 482 | 8 | 3 | 6 | 4.7 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)c(O)c2)C1=O)=C\c1ccccc1 | 10.6019/CHEMBL5442687 | |||
| CHEMBL1384502 | 29474 | None | 32 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 16 | 2 | ChEMBL | 482 | 8 | 3 | 6 | 4.7 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)c(O)c2)C1=O)=C\c1ccccc1 | 10.6019/CHEMBL5442687 | |||
| 16437205 | 32011 | None | 8 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -2 | 3 | ChEMBL | 486 | 6 | 1 | 7 | 2.7 | CCC1CCCCN1S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 | nan | |||
| CHEMBL1407961 | 32011 | None | 8 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -2 | 3 | ChEMBL | 486 | 6 | 1 | 7 | 2.7 | CCC1CCCCN1S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 | nan | |||
| 1416931 | 23426 | None | 2 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 426 | 7 | 2 | 5 | 4.0 | O=C(CCCN1C(=O)/C(=C\c2ccccc2)SC1=S)Nc1ccc(C(=O)O)cc1 | nan | |||
| CHEMBL1333032 | 23426 | None | 2 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 426 | 7 | 2 | 5 | 4.0 | O=C(CCCN1C(=O)/C(=C\c2ccccc2)SC1=S)Nc1ccc(C(=O)O)cc1 | nan | |||
| 150149078 | 186450 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 282 | 2 | 2 | 4 | 2.9 | O=C(O)c1cc2cc(-c3ccccc3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4875041 | 186450 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 282 | 2 | 2 | 4 | 2.9 | O=C(O)c1cc2cc(-c3ccccc3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 156419 | 938 | None | 48 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -79 | 20 | ChEMBL | 357 | 6 | 1 | 1 | 6.1 | C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F | 10.6019/CHEMBL5442687 | |||
| 156419.0 | 938 | None | 48 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -79 | 20 | ChEMBL | 357 | 6 | 1 | 1 | 6.1 | C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F | 10.6019/CHEMBL5442687 | |||
| 3308 | 938 | None | 48 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -79 | 20 | ChEMBL | 357 | 6 | 1 | 1 | 6.1 | C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F | 10.6019/CHEMBL5442687 | |||
| 647 | 938 | None | 48 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -79 | 20 | ChEMBL | 357 | 6 | 1 | 1 | 6.1 | C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F | 10.6019/CHEMBL5442687 | |||
| CHEMBL1201284 | 938 | None | 48 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -79 | 20 | ChEMBL | 357 | 6 | 1 | 1 | 6.1 | C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F | 10.6019/CHEMBL5442687 | |||
| DB01012 | 938 | None | 48 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -79 | 20 | ChEMBL | 357 | 6 | 1 | 1 | 6.1 | C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F | 10.6019/CHEMBL5442687 | |||
| 2286812 | 29474 | None | 32 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 16 | 2 | ChEMBL | 482 | 8 | 3 | 6 | 4.7 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)c(O)c2)C1=O)=C\c1ccccc1 | 10.6019/CHEMBL5442687 | |||
| CHEMBL1384502 | 29474 | None | 32 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 16 | 2 | ChEMBL | 482 | 8 | 3 | 6 | 4.7 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)c(O)c2)C1=O)=C\c1ccccc1 | 10.6019/CHEMBL5442687 | |||
| 1890 | 2759 | None | 31 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -26 | 28 | ChEMBL | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | 10.6019/CHEMBL5442687 | |||
| 4449 | 2759 | None | 31 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -26 | 28 | ChEMBL | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | 10.6019/CHEMBL5442687 | |||
| 7247 | 2759 | None | 31 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -26 | 28 | ChEMBL | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | 10.6019/CHEMBL5442687 | |||
| CHEMBL623 | 2759 | None | 31 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -26 | 28 | ChEMBL | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | 10.6019/CHEMBL5442687 | |||
| DB01149 | 2759 | None | 31 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -26 | 28 | ChEMBL | 469 | 10 | 0 | 7 | 3.6 | CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl | 10.6019/CHEMBL5442687 | |||
| 42642645 | 16406 | None | 50 | Human | Functional | pIC50 | = | 5.5 | 5.5 | 1 | 5 | ChEMBL | 632 | 12 | 2 | 8 | 5.8 | COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 | 10.6019/CHEMBL5442687 | |||
| CHEMBL1230609 | 16406 | None | 50 | Human | Functional | pIC50 | = | 5.5 | 5.5 | 1 | 5 | ChEMBL | 632 | 12 | 2 | 8 | 5.8 | COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 | 10.6019/CHEMBL5442687 | |||
| 12533774 | 185624 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 316 | 2 | 2 | 6 | 1.6 | Cc1c2oc(=O)c(C(=O)O)cc2cc2cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4862654 | 185624 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 316 | 2 | 2 | 6 | 1.6 | Cc1c2oc(=O)c(C(=O)O)cc2cc2cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634316 | 186448 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 426 | 4 | 2 | 7 | 3.1 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)c(F)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4875009 | 186448 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 426 | 4 | 2 | 7 | 3.1 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)c(F)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| 10219 | 188904 | None | 34 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -2 | 11 | ChEMBL | 480 | 7 | 1 | 6 | 4.9 | CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21 | 10.6019/CHEMBL5442687 | |||
| CHEMBL493439 | 188904 | None | 34 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -2 | 11 | ChEMBL | 480 | 7 | 1 | 6 | 4.9 | CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21 | 10.6019/CHEMBL5442687 | |||
| CHEMBL50588 | 188904 | None | 34 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -2 | 11 | ChEMBL | 480 | 7 | 1 | 6 | 4.9 | CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21 | 10.6019/CHEMBL5442687 | |||
| 24792182 | 55100 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -1 | 2 | ChEMBL | 417 | 6 | 1 | 5 | 5.2 | COc1ccc(C)cc1Nc1n[n+](-c2ccccc2)c(-c2ccc(N(C)C)cc2)s1 | nan | |||
| CHEMBL1306983 | 55100 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -1 | 2 | ChEMBL | 417 | 6 | 1 | 5 | 5.2 | COc1ccc(C)cc1Nc1n[n+](-c2ccccc2)c(-c2ccc(N(C)C)cc2)s1 | nan | |||
| CHEMBL1616747 | 55100 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -1 | 2 | ChEMBL | 417 | 6 | 1 | 5 | 5.2 | COc1ccc(C)cc1Nc1n[n+](-c2ccccc2)c(-c2ccc(N(C)C)cc2)s1 | nan | |||
| 57134579 | 162727 | None | 21 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 239 | 1 | 2 | 4 | 1.2 | Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4169520 | 162727 | None | 21 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 239 | 1 | 2 | 4 | 1.2 | Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| 145974046 | 163107 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.2 | Cc1cccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4175617 | 163107 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.2 | Cc1cccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| 42611190 | 3156 | None | 14 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -933 | 21 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442687 | |||
| 5802 | 3156 | None | 14 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -933 | 21 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442687 | |||
| CHEMBL1800685 | 3156 | None | 14 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -933 | 21 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442687 | |||
| 25074316 | 186476 | None | 25 | Human | Functional | pIC50 | = | 5.4 | 5.4 | 1 | 2 | ChEMBL | 421 | 5 | 1 | 8 | 2.9 | COC1CCN(c2cccc(-c3cc(NC(C)=O)nc(-n4nc(C)cc4C)n3)n2)CC1 | 10.6019/CHEMBL5442687 | |||
| CHEMBL487553 | 186476 | None | 25 | Human | Functional | pIC50 | = | 5.4 | 5.4 | 1 | 2 | ChEMBL | 421 | 5 | 1 | 8 | 2.9 | COC1CCN(c2cccc(-c3cc(NC(C)=O)nc(-n4nc(C)cc4C)n3)n2)CC1 | 10.6019/CHEMBL5442687 | |||
| 487 | 3634 | None | 20 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -1 | 9 | ChEMBL | 609 | 10 | 1 | 8 | 6.0 | COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C | 10.6019/CHEMBL5442687 | |||
| 60602 | 3634 | None | 20 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -1 | 9 | ChEMBL | 609 | 10 | 1 | 8 | 6.0 | COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C | 10.6019/CHEMBL5442687 | |||
| CHEMBL405355 | 3634 | None | 20 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -1 | 9 | ChEMBL | 609 | 10 | 1 | 8 | 6.0 | COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C | 10.6019/CHEMBL5442687 | |||
| DB09239 | 3634 | None | 20 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -1 | 9 | ChEMBL | 609 | 10 | 1 | 8 | 6.0 | COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C | 10.6019/CHEMBL5442687 | |||
| 13950957 | 157420 | None | 8 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 284 | 1 | 2 | 4 | 2.0 | O=C(O)c1cc2cc(Br)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4077503 | 157420 | None | 8 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 284 | 1 | 2 | 4 | 2.0 | O=C(O)c1cc2cc(Br)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 9581012 | 59607 | None | 3 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 415 | 5 | 2 | 6 | 3.3 | COC(=O)c1cnn(-c2ccc(F)cc2F)c1/C=N/NC(=S)Nc1ccccc1 | nan | |||
| CHEMBL1718866 | 59607 | None | 3 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 415 | 5 | 2 | 6 | 3.3 | COC(=O)c1cnn(-c2ccc(F)cc2F)c1/C=N/NC(=S)Nc1ccccc1 | nan | |||
| 6393553 | 47100 | None | 4 | Human | Functional | pIC50 | = | 5.4 | 5.4 | 5 | 2 | ChEMBL | 311 | 5 | 1 | 5 | 3.0 | CC(NC(=O)/C(C#N)=C/c1ccc([N+](=O)[O-])o1)c1ccccc1 | nan | |||
| CHEMBL1542492 | 47100 | None | 4 | Human | Functional | pIC50 | = | 5.4 | 5.4 | 5 | 2 | ChEMBL | 311 | 5 | 1 | 5 | 3.0 | CC(NC(=O)/C(C#N)=C/c1ccc([N+](=O)[O-])o1)c1ccccc1 | nan | |||
| 52936725 | 61270 | None | 22 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -812 | 10 | ChEMBL | 432 | 6 | 2 | 4 | 6.3 | Cc1cc(C)cc(-c2cnc3cc(Cl)c(-c4cccc(O)c4)cc3c2OCCCN)c1 | 10.6019/CHEMBL5442687 | |||
| CHEMBL1766103 | 61270 | None | 22 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -812 | 10 | ChEMBL | 432 | 6 | 2 | 4 | 6.3 | Cc1cc(C)cc(-c2cnc3cc(Cl)c(-c4cccc(O)c4)cc3c2OCCCN)c1 | 10.6019/CHEMBL5442687 | |||
| 145952039 | 162903 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccccc1C(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4172440 | 162903 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccccc1C(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| 28 | 3496 | None | 35 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -1 | 15 | ChEMBL | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.6019/CHEMBL5442687 | |||
| 3292447 | 3496 | None | 35 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -1 | 15 | ChEMBL | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.6019/CHEMBL5442687 | |||
| CHEMBL20963 | 3496 | None | 35 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -1 | 15 | ChEMBL | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.6019/CHEMBL5442687 | |||
| 2269231 | 45934 | None | 6 | Human | Functional | pIC50 | = | 5.4 | 5.4 | 13 | 2 | ChEMBL | 470 | 7 | 2 | 7 | 3.7 | O=C(CCCN1C(=O)/C(=C/c2ccc3c(c2)OCO3)SC1=S)Nc1ccc(C(=O)O)cc1 | nan | |||
| CHEMBL1532025 | 45934 | None | 6 | Human | Functional | pIC50 | = | 5.4 | 5.4 | 13 | 2 | ChEMBL | 470 | 7 | 2 | 7 | 3.7 | O=C(CCCN1C(=O)/C(=C/c2ccc3c(c2)OCO3)SC1=S)Nc1ccc(C(=O)O)cc1 | nan | |||
| 145959908 | 162156 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccccc1Cl | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4160515 | 162156 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccccc1Cl | 10.1021/acsmedchemlett.7b00510 | |||
| 9581013 | 59730 | None | 3 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 351 | 4 | 2 | 6 | 1.7 | CNC(=S)N/N=C/c1c(C(=O)OC)cnn1-c1ccc(Cl)cc1 | nan | |||
| CHEMBL1723578 | 59730 | None | 3 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 351 | 4 | 2 | 6 | 1.7 | CNC(=S)N/N=C/c1c(C(=O)OC)cnn1-c1ccc(Cl)cc1 | nan | |||
| 11498 | 3019 | None | 34 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -57 | 8 | ChEMBL | 392 | 3 | 1 | 5 | 4.1 | CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC | 10.6019/CHEMBL5442687 | |||
| 4995951 | 3019 | None | 34 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -57 | 8 | ChEMBL | 392 | 3 | 1 | 5 | 4.1 | CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC | 10.6019/CHEMBL5442687 | |||
| CHEMBL59898 | 3019 | None | 34 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -57 | 8 | ChEMBL | 392 | 3 | 1 | 5 | 4.1 | CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC | 10.6019/CHEMBL5442687 | |||
| 44634573 | 2748 | None | 1 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -489 | 15 | ChEMBL | 465 | 6 | 0 | 2 | 5.0 | Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 | 10.6019/CHEMBL5442687 | |||
| 9168 | 2748 | None | 1 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -489 | 15 | ChEMBL | 465 | 6 | 0 | 2 | 5.0 | Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 | 10.6019/CHEMBL5442687 | |||
| CHEMBL1474387 | 2748 | None | 1 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -489 | 15 | ChEMBL | 465 | 6 | 0 | 2 | 5.0 | Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 | 10.6019/CHEMBL5442687 | |||
| CHEMBL1622930 | 2748 | None | 1 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -489 | 15 | ChEMBL | 465 | 6 | 0 | 2 | 5.0 | Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 | 10.6019/CHEMBL5442687 | |||
| 12533774 | 185624 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 316 | 2 | 2 | 6 | 1.6 | Cc1c2oc(=O)c(C(=O)O)cc2cc2cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4862654 | 185624 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 316 | 2 | 2 | 6 | 1.6 | Cc1c2oc(=O)c(C(=O)O)cc2cc2cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 24901704 | 95043 | None | 55 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -2 | 4 | ChEMBL | 517 | 6 | 2 | 7 | 5.7 | Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5)cc4F)c3s2)c1 | 10.6019/CHEMBL5442687 | |||
| CHEMBL254760 | 95043 | None | 55 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -2 | 4 | ChEMBL | 517 | 6 | 2 | 7 | 5.7 | Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5)cc4F)c3s2)c1 | 10.6019/CHEMBL5442687 | |||
| 2841621 | 27708 | None | 4 | Human | Functional | pIC50 | = | 5.4 | 5.4 | 2 | 3 | ChEMBL | 354 | 4 | 0 | 4 | 3.8 | CCOC(=O)C1=C(Cc2ccc(Cl)cc2)C(=O)c2ccccc2C1=O | nan | |||
| CHEMBL1370183 | 27708 | None | 4 | Human | Functional | pIC50 | = | 5.4 | 5.4 | 2 | 3 | ChEMBL | 354 | 4 | 0 | 4 | 3.8 | CCOC(=O)C1=C(Cc2ccc(Cl)cc2)C(=O)c2ccccc2C1=O | nan | |||
| 154634320 | 186716 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 302 | 2 | 2 | 6 | 1.3 | O=C(O)c1cc2c(ccc3cc(C(=O)O)c(=O)oc32)oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4879017 | 186716 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 302 | 2 | 2 | 6 | 1.3 | O=C(O)c1cc2c(ccc3cc(C(=O)O)c(=O)oc32)oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 154634334 | 185531 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 396 | 3 | 2 | 6 | 3.1 | O=C(O)c1cc2c(oc1=O)c(-c1ccccc1F)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4861414 | 185531 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 396 | 3 | 2 | 6 | 3.1 | O=C(O)c1cc2c(oc1=O)c(-c1ccccc1F)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 145950576 | 162974 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 333 | 3 | 2 | 5 | 2.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccco1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4173352 | 162974 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 333 | 3 | 2 | 5 | 2.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccco1 | 10.1021/acsmedchemlett.7b00510 | |||
| 9901086 | 187737 | None | 28 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -3630 | 6 | ChEMBL | 304 | 4 | 1 | 5 | 2.1 | Clc1cccc(COc2cncc(N3CCNCC3)n2)c1 | 10.6019/CHEMBL5442687 | |||
| CHEMBL4743049 | 187737 | None | 28 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -3630 | 6 | ChEMBL | 304 | 4 | 1 | 5 | 2.1 | Clc1cccc(COc2cncc(N3CCNCC3)n2)c1 | 10.6019/CHEMBL5442687 | |||
| CHEMBL494947 | 187737 | None | 28 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -3630 | 6 | ChEMBL | 304 | 4 | 1 | 5 | 2.1 | Clc1cccc(COc2cncc(N3CCNCC3)n2)c1 | 10.6019/CHEMBL5442687 | |||
| 1692 | 2154 | None | 25 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -147 | 18 | ChEMBL | 411 | 6 | 2 | 4 | 5.5 | CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C | 10.6019/CHEMBL5442687 | |||
| 5311340 | 2154 | None | 25 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -147 | 18 | ChEMBL | 411 | 6 | 2 | 4 | 5.5 | CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C | 10.6019/CHEMBL5442687 | |||
| CHEMBL140979 | 2154 | None | 25 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -147 | 18 | ChEMBL | 411 | 6 | 2 | 4 | 5.5 | CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C | 10.6019/CHEMBL5442687 | |||
| 56646802 | 68080 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 351 | 1 | 0 | 4 | 3.8 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1c(F)c(F)c(F)c(F)c1F | 10.1021/jm200999f | |||
| CHEMBL1914577 | 68080 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 351 | 1 | 0 | 4 | 3.8 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1c(F)c(F)c(F)c(F)c1F | 10.1021/jm200999f | |||
| 130 | 3500 | None | 32 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -2290 | 10 | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.6019/CHEMBL5442687 | |||
| 3378093 | 3500 | None | 32 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -2290 | 10 | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.6019/CHEMBL5442687 | |||
| CHEMBL281350 | 3500 | None | 32 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -2290 | 10 | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.6019/CHEMBL5442687 | |||
| 5346366 | 41511 | None | 4 | Human | Functional | pIC50 | = | 5.3 | 5.3 | 2 | 2 | ChEMBL | 489 | 6 | 1 | 6 | 5.3 | O=C(Nc1ccc2nc(SCc3ccccc3)sc2c1)c1ccccc1C(=O)N1CCOCC1 | nan | |||
| CHEMBL1490915 | 41511 | None | 4 | Human | Functional | pIC50 | = | 5.3 | 5.3 | 2 | 2 | ChEMBL | 489 | 6 | 1 | 6 | 5.3 | O=C(Nc1ccc2nc(SCc3ccccc3)sc2c1)c1ccccc1C(=O)N1CCOCC1 | nan | |||
| 154634333 | 185321 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 352 | 2 | 2 | 6 | 2.4 | O=C(O)c1cc2c3ccccc3c3cc(C(=O)O)c(=O)oc3c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4857772 | 185321 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 352 | 2 | 2 | 6 | 2.4 | O=C(O)c1cc2c3ccccc3c3cc(C(=O)O)c(=O)oc3c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 9581014 | 60016 | None | 1 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 337 | 4 | 2 | 6 | 1.5 | COC(=O)c1cnn(-c2ccc(Cl)cc2)c1/C=N/NC(N)=S | nan | |||
| CHEMBL1734603 | 60016 | None | 1 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 337 | 4 | 2 | 6 | 1.5 | COC(=O)c1cnn(-c2ccc(Cl)cc2)c1/C=N/NC(N)=S | nan | |||
| 662 | 3680 | None | 7 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -2 | 12 | ChEMBL | 756 | 14 | 2 | 8 | 6.3 | COc1ccc2c(c1)ccc(c2)S(=O)(=O)N[C@@H](c1ccc2c(c1)OCO2)CC(=O)N[C@@H](C(=O)N(C(C)C)C)Cc1ccc(cc1)CN1[C@H](C)CCC[C@@H]1C | 10.6019/CHEMBL5442687 | |||
| 9853583 | 3680 | None | 7 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -2 | 12 | ChEMBL | 756 | 14 | 2 | 8 | 6.3 | COc1ccc2c(c1)ccc(c2)S(=O)(=O)N[C@@H](c1ccc2c(c1)OCO2)CC(=O)N[C@@H](C(=O)N(C(C)C)C)Cc1ccc(cc1)CN1[C@H](C)CCC[C@@H]1C | 10.6019/CHEMBL5442687 | |||
| CHEMBL2021721 | 3680 | None | 7 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -2 | 12 | ChEMBL | 756 | 14 | 2 | 8 | 6.3 | COc1ccc2c(c1)ccc(c2)S(=O)(=O)N[C@@H](c1ccc2c(c1)OCO2)CC(=O)N[C@@H](C(=O)N(C(C)C)C)Cc1ccc(cc1)CN1[C@H](C)CCC[C@@H]1C | 10.6019/CHEMBL5442687 | |||
| 53258899 | 68089 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 268 | 6 | 1 | 3 | 4.8 | CCCCCCc1csc2cc(C(=O)O)sc12 | 10.1021/jm200999f | |||
| CHEMBL1914586 | 68089 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 268 | 6 | 1 | 3 | 4.8 | CCCCCCc1csc2cc(C(=O)O)sc12 | 10.1021/jm200999f | |||
| 152243845 | 185005 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 324 | 3 | 2 | 4 | 4.0 | CC(C)c1ccc(-c2cc3cc(C(=O)O)c(=O)oc3cc2O)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4853043 | 185005 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 324 | 3 | 2 | 4 | 4.0 | CC(C)c1ccc(-c2cc3cc(C(=O)O)c(=O)oc3cc2O)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634332 | 185233 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4856506 | 185233 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634330 | 186058 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 396 | 3 | 2 | 6 | 3.1 | O=C(O)c1cc2c(oc1=O)c(-c1cccc(F)c1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4869539 | 186058 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 396 | 3 | 2 | 6 | 3.1 | O=C(O)c1cc2c(oc1=O)c(-c1cccc(F)c1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 1214658 | 59491 | None | 8 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -4 | 3 | ChEMBL | 392 | 4 | 0 | 5 | 5.5 | COc1ccc(-n2cc3c(-c4ccc(-c5ccccc5)cc4)nnc(C)c3n2)cc1 | nan | |||
| CHEMBL1713756 | 59491 | None | 8 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -4 | 3 | ChEMBL | 392 | 4 | 0 | 5 | 5.5 | COc1ccc(-n2cc3c(-c4ccc(-c5ccccc5)cc4)nnc(C)c3n2)cc1 | nan | |||
| 135399235 | 4134 | None | 41 | Human | Functional | pIC50 | = | 7.3 | 7.3 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.0c01624 | |||
| 2919 | 4134 | None | 41 | Human | Functional | pIC50 | = | 7.3 | 7.3 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.0c01624 | |||
| 5722 | 4134 | None | 41 | Human | Functional | pIC50 | = | 7.3 | 7.3 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Functional | pIC50 | = | 7.3 | 7.3 | -18 | 3 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634321 | 186103 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2c3oc(=O)c(C(=O)O)cc3cc3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4870213 | 186103 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2c3oc(=O)c(C(=O)O)cc3cc3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634336 | 186174 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccccc1-c1c2oc(=O)c(C(=O)O)cc2cc2cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4871203 | 186174 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccccc1-c1c2oc(=O)c(C(=O)O)cc2cc2cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634314 | 186715 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccccc1-c1cc2cc(C(=O)O)c(=O)oc2c2cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4878979 | 186715 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccccc1-c1cc2cc(C(=O)O)c(=O)oc2c2cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 145955278 | 162654 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccc(Cl)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4168406 | 162654 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1cccc(Cl)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| 21337671 | 68086 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 297 | 1 | 0 | 4 | 3.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(F)cc1F | 10.1021/jm200999f | |||
| CHEMBL1914583 | 68086 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 297 | 1 | 0 | 4 | 3.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(F)cc1F | 10.1021/jm200999f | |||
| 68324914 | 185837 | None | 34 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 284 | 2 | 2 | 5 | 3.6 | O=C(O)c1cc2sc3cc(C(=O)O)sc3c2s1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4865971 | 185837 | None | 34 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 284 | 2 | 2 | 5 | 3.6 | O=C(O)c1cc2sc3cc(C(=O)O)sc3c2s1 | 10.1021/acs.jmedchem.0c01624 | |||
| 7424594 | 53005 | None | 2 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 375 | 5 | 1 | 3 | 5.3 | O=C(/C=C/c1ccco1)c1ccc(NC(=O)C23CC4CC(CC(C4)C2)C3)cc1 | nan | |||
| CHEMBL1596753 | 53005 | None | 2 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 375 | 5 | 1 | 3 | 5.3 | O=C(/C=C/c1ccco1)c1ccc(NC(=O)C23CC4CC(CC(C4)C2)C3)cc1 | nan | |||
| 145959592 | 162444 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.2 | Cc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4164993 | 162444 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.2 | Cc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 6202912 | 48223 | None | 5 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 502 | 9 | 3 | 8 | 3.7 | COc1ccc(/C=C2\SC(=S)N(CCCC(=O)Nc3ccc(C(=O)O)c(O)c3)C2=O)cc1OC | nan | |||
| CHEMBL1552304 | 48223 | None | 5 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 502 | 9 | 3 | 8 | 3.7 | COc1ccc(/C=C2\SC(=S)N(CCCC(=O)Nc3ccc(C(=O)O)c(O)c3)C2=O)cc1OC | nan | |||
| 10150497 | 4074 | None | 40 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -812 | 15 | ChEMBL | 380 | 4 | 1 | 7 | 2.7 | NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2 | 10.6019/CHEMBL5442687 | |||
| 3240 | 4074 | None | 40 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -812 | 15 | ChEMBL | 380 | 4 | 1 | 7 | 2.7 | NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2 | 10.6019/CHEMBL5442687 | |||
| CHEMBL392760 | 4074 | None | 40 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -812 | 15 | ChEMBL | 380 | 4 | 1 | 7 | 2.7 | NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2 | 10.6019/CHEMBL5442687 | |||
| 1477048 | 29742 | None | 17 | Human | Functional | pIC50 | = | 6.3 | 6.3 | 23 | 2 | ChEMBL | 438 | 5 | 0 | 5 | 4.3 | CN(C)/C=C/C(=O)c1ccc(N2CCN(c3ncc(C(F)(F)F)cc3Cl)CC2)cc1 | nan | |||
| CHEMBL1386711 | 29742 | None | 17 | Human | Functional | pIC50 | = | 6.3 | 6.3 | 23 | 2 | ChEMBL | 438 | 5 | 0 | 5 | 4.3 | CN(C)/C=C/C(=O)c1ccc(N2CCN(c3ncc(C(F)(F)F)cc3Cl)CC2)cc1 | nan | |||
| 5936070 | 34062 | None | 5 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 427 | 4 | 1 | 4 | 6.4 | CC(=O)Nc1sc(/C(C#N)=C/c2ccc(Cl)c(Cl)c2)nc1-c1ccc(C)cc1 | nan | |||
| CHEMBL1424929 | 34062 | None | 5 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 427 | 4 | 1 | 4 | 6.4 | CC(=O)Nc1sc(/C(C#N)=C/c2ccc(Cl)c(Cl)c2)nc1-c1ccc(C)cc1 | nan | |||
| 22475020 | 96056 | None | 19 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -489 | 4 | ChEMBL | 491 | 3 | 0 | 4 | 5.4 | O=C(c1cc2c(cc1F)OC(c1ccc(F)cc1)(c1ccc(Cl)cc1Cl)O2)N1CCOCC1 | 10.6019/CHEMBL5442687 | |||
| CHEMBL259656 | 96056 | None | 19 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -489 | 4 | ChEMBL | 491 | 3 | 0 | 4 | 5.4 | O=C(c1cc2c(cc1F)OC(c1ccc(F)cc1)(c1ccc(Cl)cc1Cl)O2)N1CCOCC1 | 10.6019/CHEMBL5442687 | |||
| 154634323 | 184710 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 380 | 2 | 2 | 6 | 2.1 | O=C(O)c1cc2c(oc1=O)c(Br)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4848949 | 184710 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 380 | 2 | 2 | 6 | 2.1 | O=C(O)c1cc2c(oc1=O)c(Br)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 151271218 | 186261 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 300 | 2 | 2 | 4 | 3.0 | O=C(O)c1cc2cc(-c3ccc(F)cc3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4872368 | 186261 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 300 | 2 | 2 | 4 | 3.0 | O=C(O)c1cc2cc(-c3ccc(F)cc3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 1609318 | 42645 | None | 7 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 297 | 12 | 2 | 4 | 3.4 | C=CCCCCCCCCc1nc(SCC(=O)O)n[nH]1 | nan | |||
| CHEMBL1500763 | 42645 | None | 7 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 297 | 12 | 2 | 4 | 3.4 | C=CCCCCCCCCc1nc(SCC(=O)O)n[nH]1 | nan | |||
| 282594 | 45361 | None | 12 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -2 | 5 | ChEMBL | 331 | 2 | 0 | 3 | 3.7 | CC(=O)N(C1=C(Cl)C(=O)c2ccccc2C1=O)C1CCCCC1 | nan | |||
| CHEMBL1526855 | 45361 | None | 12 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -2 | 5 | ChEMBL | 331 | 2 | 0 | 3 | 3.7 | CC(=O)N(C1=C(Cl)C(=O)c2ccccc2C1=O)C1CCCCC1 | nan | |||
| 5334290 | 25931 | None | 7 | Human | Functional | pIC50 | = | 6.3 | 6.3 | 7 | 2 | ChEMBL | 388 | 7 | 1 | 4 | 5.6 | CCN(CC)c1ccc(/C=C(/C#N)c2nc3cc(C)ccc3[nH]2)c(OC(C)C)c1 | nan | |||
| CHEMBL1353925 | 25931 | None | 7 | Human | Functional | pIC50 | = | 6.3 | 6.3 | 7 | 2 | ChEMBL | 388 | 7 | 1 | 4 | 5.6 | CCN(CC)c1ccc(/C=C(/C#N)c2nc3cc(C)ccc3[nH]2)c(OC(C)C)c1 | nan | |||
| 4189659 | 28061 | None | 3 | Human | Functional | pIC50 | = | 6.3 | 6.3 | 6 | 2 | ChEMBL | 493 | 8 | 2 | 7 | 5.1 | CC(C)c1ccc(NC(=O)CSc2nc3ccsc3c(=O)n2Cc2ccc(C(=O)O)cc2)cc1 | nan | |||
| CHEMBL1372770 | 28061 | None | 3 | Human | Functional | pIC50 | = | 6.3 | 6.3 | 6 | 2 | ChEMBL | 493 | 8 | 2 | 7 | 5.1 | CC(C)c1ccc(NC(=O)CSc2nc3ccsc3c(=O)n2Cc2ccc(C(=O)O)cc2)cc1 | nan | |||
| 2269231 | 45934 | None | 6 | Human | Functional | pIC50 | = | 6.3 | 6.3 | 13 | 2 | ChEMBL | 470 | 7 | 2 | 7 | 3.7 | O=C(CCCN1C(=O)/C(=C/c2ccc3c(c2)OCO3)SC1=S)Nc1ccc(C(=O)O)cc1 | nan | |||
| CHEMBL1532025 | 45934 | None | 6 | Human | Functional | pIC50 | = | 6.3 | 6.3 | 13 | 2 | ChEMBL | 470 | 7 | 2 | 7 | 3.7 | O=C(CCCN1C(=O)/C(=C/c2ccc3c(c2)OCO3)SC1=S)Nc1ccc(C(=O)O)cc1 | nan | |||
| 5733585 | 40983 | None | 6 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 486 | 9 | 2 | 7 | 4.0 | COc1ccc(/C=C2\SC(=S)N(CCCC(=O)Nc3cccc(C(=O)O)c3)C2=O)cc1OC | nan | |||
| CHEMBL1487024 | 40983 | None | 6 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 486 | 9 | 2 | 7 | 4.0 | COc1ccc(/C=C2\SC(=S)N(CCCC(=O)Nc3cccc(C(=O)O)c3)C2=O)cc1OC | nan | |||
| 10071196 | 3124 | None | 53 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -380 | 15 | ChEMBL | 427 | 8 | 1 | 3 | 4.7 | CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C | 10.6019/CHEMBL5442687 | |||
| 10071196.0 | 3124 | None | 53 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -380 | 15 | ChEMBL | 427 | 8 | 1 | 3 | 4.7 | CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C | 10.6019/CHEMBL5442687 | |||
| 5142 | 3124 | None | 53 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -380 | 15 | ChEMBL | 427 | 8 | 1 | 3 | 4.7 | CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C | 10.6019/CHEMBL5442687 | |||
| 8423 | 3124 | None | 53 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -380 | 15 | ChEMBL | 427 | 8 | 1 | 3 | 4.7 | CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C | 10.6019/CHEMBL5442687 | |||
| CHEMBL2111101 | 3124 | None | 53 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -380 | 15 | ChEMBL | 427 | 8 | 1 | 3 | 4.7 | CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C | 10.6019/CHEMBL5442687 | |||
| DB05316 | 3124 | None | 53 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -380 | 15 | ChEMBL | 427 | 8 | 1 | 3 | 4.7 | CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C | 10.6019/CHEMBL5442687 | |||
| 4189659 | 28061 | None | 3 | Human | Functional | pIC50 | = | 5.3 | 5.3 | 6 | 2 | ChEMBL | 493 | 8 | 2 | 7 | 5.1 | CC(C)c1ccc(NC(=O)CSc2nc3ccsc3c(=O)n2Cc2ccc(C(=O)O)cc2)cc1 | nan | |||
| CHEMBL1372770 | 28061 | None | 3 | Human | Functional | pIC50 | = | 5.3 | 5.3 | 6 | 2 | ChEMBL | 493 | 8 | 2 | 7 | 5.1 | CC(C)c1ccc(NC(=O)CSc2nc3ccsc3c(=O)n2Cc2ccc(C(=O)O)cc2)cc1 | nan | |||
| 53258795 | 68093 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 416 | 11 | 1 | 3 | 7.5 | CCCCCCCCCCCc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| CHEMBL1914590 | 68093 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 416 | 11 | 1 | 3 | 7.5 | CCCCCCCCCCCc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| 660319 | 11007 | None | 59 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 184 | 1 | 1 | 3 | 2.7 | O=C(O)c1cc2sccc2s1 | 10.1021/jm200999f | |||
| CHEMBL1173787 | 11007 | None | 59 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 184 | 1 | 1 | 3 | 2.7 | O=C(O)c1cc2sccc2s1 | 10.1021/jm200999f | |||
| 5722655 | 20117 | None | 3 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 17 | 2 | ChEMBL | 388 | 8 | 1 | 4 | 5.6 | CCCOc1cc(N(CC)CC)ccc1/C=C(/C#N)c1nc2cc(C)ccc2[nH]1 | nan | |||
| CHEMBL1304179 | 20117 | None | 3 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 17 | 2 | ChEMBL | 388 | 8 | 1 | 4 | 5.6 | CCCOc1cc(N(CC)CC)ccc1/C=C(/C#N)c1nc2cc(C)ccc2[nH]1 | nan | |||
| 1024 | 16495 | None | 63 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 330 | 3 | 4 | 6 | 0.6 | O=C(O)c1cc(C(=O)O)c2c(n1)C(=O)C(=O)c1cc(C(=O)O)[nH]c1-2 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL1235421 | 16495 | None | 63 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 330 | 3 | 4 | 6 | 0.6 | O=C(O)c1cc(C(=O)O)c2c(n1)C(=O)C(=O)c1cc(C(=O)O)[nH]c1-2 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634318 | 186105 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 318 | 2 | 3 | 7 | 1.0 | O=C(O)c1cc2cc3cc(C(=O)O)c(=O)oc3c(O)c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4870255 | 186105 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 318 | 2 | 3 | 7 | 1.0 | O=C(O)c1cc2cc3cc(C(=O)O)c(=O)oc3c(O)c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 53258898 | 68095 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 472 | 15 | 1 | 3 | 9.1 | CCCCCCCCCCCCCCCc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| CHEMBL1914592 | 68095 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 472 | 15 | 1 | 3 | 9.1 | CCCCCCCCCCCCCCCc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/jm200999f | |||
| 209 | 3057 | None | 57 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -2630 | 25 | ChEMBL | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | 10.6019/CHEMBL5442687 | |||
| 2113 | 3057 | None | 57 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -2630 | 25 | ChEMBL | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | 10.6019/CHEMBL5442687 | |||
| 4748 | 3057 | None | 57 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -2630 | 25 | ChEMBL | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | 10.6019/CHEMBL5442687 | |||
| 4748.0 | 3057 | None | 57 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -2630 | 25 | ChEMBL | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | 10.6019/CHEMBL5442687 | |||
| CHEMBL567 | 3057 | None | 57 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -2630 | 25 | ChEMBL | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | 10.6019/CHEMBL5442687 | |||
| DB00850 | 3057 | None | 57 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -2630 | 25 | ChEMBL | 403 | 6 | 1 | 5 | 3.9 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 | 10.6019/CHEMBL5442687 | |||
| 154634334 | 185531 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 396 | 3 | 2 | 6 | 3.1 | O=C(O)c1cc2c(oc1=O)c(-c1ccccc1F)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4861414 | 185531 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 396 | 3 | 2 | 6 | 3.1 | O=C(O)c1cc2c(oc1=O)c(-c1ccccc1F)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 154634330 | 186058 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 396 | 3 | 2 | 6 | 3.1 | O=C(O)c1cc2c(oc1=O)c(-c1cccc(F)c1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4869539 | 186058 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 396 | 3 | 2 | 6 | 3.1 | O=C(O)c1cc2c(oc1=O)c(-c1cccc(F)c1)cc1cc(C(=O)O)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 164610101 | 184981 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 342 | 4 | 2 | 6 | 2.5 | COc1cc(C(=O)O)nc2c(C)c3nc(C(=O)O)cc(OC)c3cc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4852667 | 184981 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 342 | 4 | 2 | 6 | 2.5 | COc1cc(C(=O)O)nc2c(C)c3nc(C(=O)O)cc(OC)c3cc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 12138435 | 68079 | None | 26 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 329 | 1 | 0 | 4 | 4.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1 | 10.1021/jm200999f | |||
| CHEMBL1914576 | 68079 | None | 26 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 329 | 1 | 0 | 4 | 4.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1 | 10.1021/jm200999f | |||
| 145951566 | 162860 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 379 | 3 | 2 | 4 | 3.2 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(F)cc1F | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4171782 | 162860 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 379 | 3 | 2 | 4 | 3.2 | O=C(Nc1cc(Br)ccc1-c1nnn[nH]1)c1ccc(F)cc1F | 10.1021/acsmedchemlett.7b00510 | |||
| 11656002 | 83044 | None | 22 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -2884 | 8 | ChEMBL | 484 | 3 | 0 | 3 | 5.8 | O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.6019/CHEMBL5442687 | |||
| CHEMBL2181247 | 83044 | None | 22 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -2884 | 8 | ChEMBL | 484 | 3 | 0 | 3 | 5.8 | O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.6019/CHEMBL5442687 | |||
| 9893924 | 4750 | None | 24 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -213 | 9 | ChEMBL | 554 | 11 | 3 | 4 | 5.4 | S=C(NCCCc1c[nH]cn1)NCCCN(Cc1ccc(Cl)c(Cl)c1)c1ccc(Br)cn1 | 10.6019/CHEMBL5442687 | |||
| CHEMBL103769 | 4750 | None | 24 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -213 | 9 | ChEMBL | 554 | 11 | 3 | 4 | 5.4 | S=C(NCCCc1c[nH]cn1)NCCCN(Cc1ccc(Cl)c(Cl)c1)c1ccc(Br)cn1 | 10.6019/CHEMBL5442687 | |||
| 16103465 | 68090 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 254 | 1 | 1 | 4 | 4.2 | Cc1csc2c1sc1cc(C(=O)O)sc12 | 10.1021/jm200999f | |||
| CHEMBL1914587 | 68090 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 254 | 1 | 1 | 4 | 4.2 | Cc1csc2c1sc1cc(C(=O)O)sc12 | 10.1021/jm200999f | |||
| 24882686 | 95359 | None | 35 | Human | Functional | pIC50 | = | 6.2 | 6.2 | -5 | 6 | ChEMBL | 499 | 6 | 1 | 7 | 4.1 | Cc1csc2c(N[C@@H](C)CN3CCN(S(=O)(=O)c4ccc(Cl)c(Cl)c4)CC3)ncnc12 | 10.6019/CHEMBL5442687 | |||
| CHEMBL256470 | 95359 | None | 35 | Human | Functional | pIC50 | = | 6.2 | 6.2 | -5 | 6 | ChEMBL | 499 | 6 | 1 | 7 | 4.1 | Cc1csc2c(N[C@@H](C)CN3CCN(S(=O)(=O)c4ccc(Cl)c(Cl)c4)CC3)ncnc12 | 10.6019/CHEMBL5442687 | |||
| 11957284 | 35945 | None | 3 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 441 | 3 | 2 | 8 | 5.0 | Cc1nnc(NC(=O)c2sc3nc(-c4cccs4)cc(C(F)(F)F)c3c2N)s1 | nan | |||
| CHEMBL1442537 | 35945 | None | 3 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 441 | 3 | 2 | 8 | 5.0 | Cc1nnc(NC(=O)c2sc3nc(-c4cccs4)cc(C(F)(F)F)c3c2N)s1 | nan | |||
| 1542103 | 22491 | None | 20 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 2 | 3 | ChEMBL | 418 | 4 | 0 | 6 | 4.2 | Cc1ccccc1N1CCN(c2ncnc3c2cnn3Cc2ccc(Cl)cc2)CC1 | nan | |||
| CHEMBL1325250 | 22491 | None | 20 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 2 | 3 | ChEMBL | 418 | 4 | 0 | 6 | 4.2 | Cc1ccccc1N1CCN(c2ncnc3c2cnn3Cc2ccc(Cl)cc2)CC1 | nan | |||
| 154634335 | 184589 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1cccc(-c2c3oc(=O)c(C(=O)O)cc3cc3cc(C(=O)O)c(=O)oc23)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4847100 | 184589 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1cccc(-c2c3oc(=O)c(C(=O)O)cc3cc3cc(C(=O)O)c(=O)oc23)c1 | 10.1021/acs.jmedchem.0c01624 | |||
| 20992 | 199528 | None | 52 | Human | Functional | pIC50 | = | 5.2 | 5.2 | 1 | 3 | ChEMBL | 276 | 7 | 0 | 4 | 0.4 | O=C1C=CC(=O)N1CCCCCCN1C(=O)C=CC1=O | nan | |||
| CHEMBL567422 | 199528 | None | 52 | Human | Functional | pIC50 | = | 5.2 | 5.2 | 1 | 3 | ChEMBL | 276 | 7 | 0 | 4 | 0.4 | O=C1C=CC(=O)N1CCCCCCN1C(=O)C=CC1=O | nan | |||
| 135413536 | 448 | None | 58 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -26302 | 7 | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.6019/CHEMBL5442687 | |||
| 230 | 448 | None | 58 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -26302 | 7 | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.6019/CHEMBL5442687 | |||
| 3490 | 448 | None | 58 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -26302 | 7 | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.6019/CHEMBL5442687 | |||
| 6918365 | 448 | None | 58 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -26302 | 7 | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.6019/CHEMBL5442687 | |||
| CHEMBL1471 | 448 | None | 58 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -26302 | 7 | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.6019/CHEMBL5442687 | |||
| DB00673 | 448 | None | 58 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -26302 | 7 | ChEMBL | 534 | 6 | 2 | 5 | 5.0 | Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C | 10.6019/CHEMBL5442687 | |||
| 24789826 | 55081 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 56 | 2 | ChEMBL | 419 | 7 | 1 | 4 | 5.8 | CCN(CC)c1ccc(-c2sc(Nc3ccccc3)n[n+]2-c2ccc(F)cc2)cc1 | nan | |||
| CHEMBL1307717 | 55081 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 56 | 2 | ChEMBL | 419 | 7 | 1 | 4 | 5.8 | CCN(CC)c1ccc(-c2sc(Nc3ccccc3)n[n+]2-c2ccc(F)cc2)cc1 | nan | |||
| CHEMBL1616626 | 55081 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 56 | 2 | ChEMBL | 419 | 7 | 1 | 4 | 5.8 | CCN(CC)c1ccc(-c2sc(Nc3ccccc3)n[n+]2-c2ccc(F)cc2)cc1 | nan | |||
| 1985027 | 32725 | None | 8 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 27 | 2 | ChEMBL | 454 | 8 | 2 | 5 | 4.6 | CCc1ccc(/C=C2\SC(=S)N(CCCC(=O)Nc3ccc(C(=O)O)cc3)C2=O)cc1 | nan | |||
| CHEMBL1413629 | 32725 | None | 8 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 27 | 2 | ChEMBL | 454 | 8 | 2 | 5 | 4.6 | CCc1ccc(/C=C2\SC(=S)N(CCCC(=O)Nc3ccc(C(=O)O)cc3)C2=O)cc1 | nan | |||
| 12138434 | 68084 | None | 1 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 317 | 4 | 0 | 4 | 4.4 | CCCCc1ccc(C2(C)OC(=C(C#N)C#N)C(C#N)=C2C)cc1 | 10.1021/jm200999f | |||
| CHEMBL1914581 | 68084 | None | 1 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 317 | 4 | 0 | 4 | 4.4 | CCCCc1ccc(C2(C)OC(=C(C#N)C#N)C(C#N)=C2C)cc1 | 10.1021/jm200999f | |||
| 164610101 | 184981 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 342 | 4 | 2 | 6 | 2.5 | COc1cc(C(=O)O)nc2c(C)c3nc(C(=O)O)cc(OC)c3cc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4852667 | 184981 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 342 | 4 | 2 | 6 | 2.5 | COc1cc(C(=O)O)nc2c(C)c3nc(C(=O)O)cc(OC)c3cc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 1803281 | 20072 | None | 6 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 15 | 2 | ChEMBL | 337 | 4 | 1 | 3 | 3.0 | CN(C)c1ccc(/C=C2\NC(=S)N(Cc3ccccc3)C2=O)cc1 | nan | |||
| CHEMBL1303807 | 20072 | None | 6 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 15 | 2 | ChEMBL | 337 | 4 | 1 | 3 | 3.0 | CN(C)c1ccc(/C=C2\NC(=S)N(Cc3ccccc3)C2=O)cc1 | nan | |||
| 798024 | 35433 | None | 2 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 245 | 3 | 1 | 4 | 1.7 | N#C/C(=C\c1ccc(N2CCCCC2)o1)C(N)=O | nan | |||
| CHEMBL1437947 | 35433 | None | 2 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 245 | 3 | 1 | 4 | 1.7 | N#C/C(=C\c1ccc(N2CCCCC2)o1)C(N)=O | nan | |||
| 6201879 | 27396 | None | 12 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 456 | 8 | 2 | 6 | 4.0 | COc1cccc(/C=C2\SC(=S)N(CCCC(=O)Nc3ccc(C(=O)O)cc3)C2=O)c1 | nan | |||
| CHEMBL1367928 | 27396 | None | 12 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 456 | 8 | 2 | 6 | 4.0 | COc1cccc(/C=C2\SC(=S)N(CCCC(=O)Nc3ccc(C(=O)O)cc3)C2=O)c1 | nan | |||
| 154634332 | 185233 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4856506 | 185233 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 145954727 | 162516 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 295 | 3 | 2 | 4 | 2.0 | CCC(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4166100 | 162516 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 295 | 3 | 2 | 4 | 2.0 | CCC(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| 5767616 | 19606 | None | 2 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 370 | 5 | 1 | 5 | 4.3 | CCOc1ccc(N(C)c2ccc(/C=C3/SC(=S)NC3=O)cc2)cc1 | nan | |||
| CHEMBL1300169 | 19606 | None | 2 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 370 | 5 | 1 | 5 | 4.3 | CCOc1ccc(N(C)c2ccc(/C=C3/SC(=S)NC3=O)cc2)cc1 | nan | |||
| 152550147 | 185434 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 300 | 2 | 2 | 4 | 3.0 | O=C(O)c1cc2cc(-c3cccc(F)c3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4859675 | 185434 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 300 | 2 | 2 | 4 | 3.0 | O=C(O)c1cc2cc(-c3cccc(F)c3)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 154634322 | 185486 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 307 | 1 | 1 | 8 | 1.0 | N#Cc1cc2c(ccc3cc(-c4nnn[nH]4)c(=O)oc32)oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4860550 | 185486 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 307 | 1 | 1 | 8 | 1.0 | N#Cc1cc2c(ccc3cc(-c4nnn[nH]4)c(=O)oc32)oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 1346847 | 21208 | None | 6 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 412 | 6 | 2 | 5 | 4.3 | Cc1ccc(/C=C2\SC(=S)N(CCCC(=O)Nc3ccc(O)cc3)C2=O)cc1 | nan | |||
| CHEMBL1312928 | 21208 | None | 6 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 412 | 6 | 2 | 5 | 4.3 | Cc1ccc(/C=C2\SC(=S)N(CCCC(=O)Nc3ccc(O)cc3)C2=O)cc1 | nan | |||
| 10868388 | 162227 | None | 37 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 239 | 1 | 2 | 4 | 1.2 | Nc1ccc(Br)cc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4161599 | 162227 | None | 37 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 239 | 1 | 2 | 4 | 1.2 | Nc1ccc(Br)cc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| 10077130 | 4007 | None | 47 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -275 | 6 | ChEMBL | 492 | 5 | 1 | 5 | 5.6 | CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]1[C@H]([C@H]2/C=C/c2ccc(cn2)c2cccc(c2)F)[C@H](OC1=O)C | 10.6019/CHEMBL5442687 | |||
| 10077130.0 | 4007 | None | 47 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -275 | 6 | ChEMBL | 492 | 5 | 1 | 5 | 5.6 | CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]1[C@H]([C@H]2/C=C/c2ccc(cn2)c2cccc(c2)F)[C@H](OC1=O)C | 10.6019/CHEMBL5442687 | |||
| 4047 | 4007 | None | 47 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -275 | 6 | ChEMBL | 492 | 5 | 1 | 5 | 5.6 | CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]1[C@H]([C@H]2/C=C/c2ccc(cn2)c2cccc(c2)F)[C@H](OC1=O)C | 10.6019/CHEMBL5442687 | |||
| 4870 | 4007 | None | 47 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -275 | 6 | ChEMBL | 492 | 5 | 1 | 5 | 5.6 | CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]1[C@H]([C@H]2/C=C/c2ccc(cn2)c2cccc(c2)F)[C@H](OC1=O)C | 10.6019/CHEMBL5442687 | |||
| CHEMBL493982 | 4007 | None | 47 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -275 | 6 | ChEMBL | 492 | 5 | 1 | 5 | 5.6 | CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]1[C@H]([C@H]2/C=C/c2ccc(cn2)c2cccc(c2)F)[C@H](OC1=O)C | 10.6019/CHEMBL5442687 | |||
| DB09030 | 4007 | None | 47 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -275 | 6 | ChEMBL | 492 | 5 | 1 | 5 | 5.6 | CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]1[C@H]([C@H]2/C=C/c2ccc(cn2)c2cccc(c2)F)[C@H](OC1=O)C | 10.6019/CHEMBL5442687 | |||
| 1502520 | 34510 | None | 16 | Human | Functional | pIC50 | = | 6.1 | 6.1 | -9 | 2 | ChEMBL | 398 | 4 | 0 | 6 | 3.8 | Cc1ccc(Cn2ncc3c(N4CCN(c5ccccc5C)CC4)ncnc32)cc1 | nan | |||
| CHEMBL1428840 | 34510 | None | 16 | Human | Functional | pIC50 | = | 6.1 | 6.1 | -9 | 2 | ChEMBL | 398 | 4 | 0 | 6 | 3.8 | Cc1ccc(Cn2ncc3c(N4CCN(c5ccccc5C)CC4)ncnc32)cc1 | nan | |||
| 3860640 | 149919 | None | 38 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -13 | 3 | ChEMBL | 331 | 2 | 3 | 3 | 3.7 | Cc1cccc2c1NC(=O)C2(c1ccc(O)cc1)c1ccc(O)cc1 | nan | |||
| CHEMBL394883 | 149919 | None | 38 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -13 | 3 | ChEMBL | 331 | 2 | 3 | 3 | 3.7 | Cc1cccc2c1NC(=O)C2(c1ccc(O)cc1)c1ccc(O)cc1 | nan | |||
| 1231538 | 27526 | None | 29 | Human | Functional | pIC50 | = | 6.1 | 6.1 | -1 | 3 | ChEMBL | 523 | 6 | 1 | 6 | 6.0 | O=C(Nc1ccc2nc(SCc3ccc(Cl)cc3)sc2c1)c1ccccc1C(=O)N1CCOCC1 | nan | |||
| CHEMBL1368962 | 27526 | None | 29 | Human | Functional | pIC50 | = | 6.1 | 6.1 | -1 | 3 | ChEMBL | 523 | 6 | 1 | 6 | 6.0 | O=C(Nc1ccc2nc(SCc3ccc(Cl)cc3)sc2c1)c1ccccc1C(=O)N1CCOCC1 | nan | |||
| 4559736 | 34682 | None | 1 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 254 | 2 | 2 | 4 | 2.7 | Nc1[nH]c2cc([N+](=O)[O-])ccc2c1-c1ccccn1 | nan | |||
| CHEMBL1430125 | 34682 | None | 1 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 254 | 2 | 2 | 4 | 2.7 | Nc1[nH]c2cc([N+](=O)[O-])ccc2c1-c1ccccn1 | nan | |||
| 326869 | 112874 | None | 2 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 314 | 2 | 4 | 4 | 1.1 | Cc1c2[nH]c(C(=O)O)cc(=O)c2cc2c(=O)cc(C(=O)O)[nH]c12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL3306990 | 112874 | None | 2 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 314 | 2 | 4 | 4 | 1.1 | Cc1c2[nH]c(C(=O)O)cc(=O)c2cc2c(=O)cc(C(=O)O)[nH]c12 | 10.1021/acs.jmedchem.0c01624 | |||
| 11646823 | 1215 | None | 50 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -851 | 2 | ChEMBL | 391 | 2 | 0 | 4 | 4.8 | Clc1nccc(c1)C#Cc1nc(n(c1C)c1ccc(cc1)OC(F)(F)F)C | 10.6019/CHEMBL5442687 | |||
| 6408 | 1215 | None | 50 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -851 | 2 | ChEMBL | 391 | 2 | 0 | 4 | 4.8 | Clc1nccc(c1)C#Cc1nc(n(c1C)c1ccc(cc1)OC(F)(F)F)C | 10.6019/CHEMBL5442687 | |||
| 6409 | 1215 | None | 50 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -851 | 2 | ChEMBL | 391 | 2 | 0 | 4 | 4.8 | Clc1nccc(c1)C#Cc1nc(n(c1C)c1ccc(cc1)OC(F)(F)F)C | 10.6019/CHEMBL5442687 | |||
| CHEMBL3410223 | 1215 | None | 50 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -851 | 2 | ChEMBL | 391 | 2 | 0 | 4 | 4.8 | Clc1nccc(c1)C#Cc1nc(n(c1C)c1ccc(cc1)OC(F)(F)F)C | 10.6019/CHEMBL5442687 | |||
| 154634331 | 184654 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 420 | 4 | 2 | 6 | 4.1 | CC(C)c1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4848109 | 184654 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 420 | 4 | 2 | 6 | 4.1 | CC(C)c1ccc(-c2cc3cc(C(=O)O)c(=O)oc3c3cc(C(=O)O)c(=O)oc23)cc1 | 10.1021/acs.jmedchem.0c01624 | |||
| 149708825 | 186497 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 300 | 2 | 2 | 4 | 3.0 | O=C(O)c1cc2cc(-c3ccccc3F)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4875771 | 186497 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 300 | 2 | 2 | 4 | 3.0 | O=C(O)c1cc2cc(-c3ccccc3F)c(O)cc2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 2277094 | 49030 | None | 6 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 470 | 7 | 2 | 7 | 3.7 | O=C(CCCN1C(=O)/C(=C/c2ccc3c(c2)OCO3)SC1=S)Nc1cccc(C(=O)O)c1 | nan | |||
| CHEMBL1560901 | 49030 | None | 6 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 470 | 7 | 2 | 7 | 3.7 | O=C(CCCN1C(=O)/C(=C/c2ccc3c(c2)OCO3)SC1=S)Nc1cccc(C(=O)O)c1 | nan | |||
| 1205881 | 36175 | None | 2 | Human | Functional | pIC50 | = | 6.1 | 6.1 | 23 | 2 | ChEMBL | 426 | 7 | 2 | 5 | 4.0 | O=C(CCCN1C(=O)/C(=C\c2ccccc2)SC1=S)Nc1cccc(C(=O)O)c1 | nan | |||
| CHEMBL1444708 | 36175 | None | 2 | Human | Functional | pIC50 | = | 6.1 | 6.1 | 23 | 2 | ChEMBL | 426 | 7 | 2 | 5 | 4.0 | O=C(CCCN1C(=O)/C(=C\c2ccccc2)SC1=S)Nc1cccc(C(=O)O)c1 | nan | |||
| 145958445 | 162225 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.2 | Cc1ccccc1C(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4161574 | 162225 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.2 | Cc1ccccc1C(=O)Nc1cc(Br)ccc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.7b00510 | |||
| 145959306 | 162409 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1cccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4164556 | 162409 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1cccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)c1 | 10.1021/acsmedchemlett.7b00510 | |||
| 145949189 | 162832 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 313 | 4 | 2 | 5 | 2.3 | COc1ccc(C(=O)Nc2cc(F)ccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4171326 | 162832 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 313 | 4 | 2 | 5 | 2.3 | COc1ccc(C(=O)Nc2cc(F)ccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 1209 | 1658 | None | 52 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -69 | 25 | ChEMBL | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442687 | |||
| 203 | 1658 | None | 52 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -69 | 25 | ChEMBL | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442687 | |||
| 3386 | 1658 | None | 52 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -69 | 25 | ChEMBL | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442687 | |||
| CHEMBL41 | 1658 | None | 52 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -69 | 25 | ChEMBL | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442687 | |||
| DB00472 | 1658 | None | 52 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -69 | 25 | ChEMBL | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442687 | |||
| 154634326 | 185198 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 404 | 2 | 2 | 8 | 1.5 | O=C(O)c1cc2c(oc1=O)c(Br)cc1cc(-c3nnn[nH]3)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4856029 | 185198 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 404 | 2 | 2 | 8 | 1.5 | O=C(O)c1cc2c(oc1=O)c(Br)cc1cc(-c3nnn[nH]3)c(=O)oc12 | 10.1021/acs.jmedchem.0c01624 | |||
| 2732121 | 38539 | None | 2 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 306 | 3 | 0 | 4 | 3.6 | CC(C)c1ccc(N2C(=O)/C(=C/N(C)C)SC2=S)cc1 | nan | |||
| CHEMBL1464544 | 38539 | None | 2 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 306 | 3 | 0 | 4 | 3.6 | CC(C)c1ccc(N2C(=O)/C(=C/N(C)C)SC2=S)cc1 | nan | |||
| 110720191 | 162552 | None | 1 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 295 | 4 | 2 | 5 | 2.1 | COc1ccc(C(=O)Nc2ccc(-c3nnn[nH]3)cc2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL4166802 | 162552 | None | 1 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 295 | 4 | 2 | 5 | 2.1 | COc1ccc(C(=O)Nc2ccc(-c3nnn[nH]3)cc2)cc1 | 10.1021/acsmedchemlett.7b00510 | |||
| 3276705 | 46407 | None | 6 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 521 | 8 | 2 | 6 | 4.3 | CCN(CC)S(=O)(=O)c1ccc(NC(=O)c2cccnc2Cl)c(NC(=O)c2cccnc2Cl)c1 | nan | |||
| CHEMBL1536628 | 46407 | None | 6 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 521 | 8 | 2 | 6 | 4.3 | CCN(CC)S(=O)(=O)c1ccc(NC(=O)c2cccnc2Cl)c(NC(=O)c2cccnc2Cl)c1 | nan | |||
| 6974996 | 72043 | None | 6 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 389 | 6 | 0 | 6 | 3.6 | CC/N=C1\S/C(=C\c2cc(OC)c(N3CCCC3)cc2OC)C(=O)N1CC | nan | |||
| CHEMBL1975147 | 72043 | None | 6 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 389 | 6 | 0 | 6 | 3.6 | CC/N=C1\S/C(=C\c2cc(OC)c(N3CCCC3)cc2OC)C(=O)N1CC | nan | |||
| 154634327 | 184845 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 380 | 2 | 2 | 6 | 2.1 | O=C(O)c1cc2cc3cc(C(=O)O)c(=O)oc3c(Br)c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| CHEMBL4850743 | 184845 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 380 | 2 | 2 | 6 | 2.1 | O=C(O)c1cc2cc3cc(C(=O)O)c(=O)oc3c(Br)c2oc1=O | 10.1021/acs.jmedchem.0c01624 | |||
| 18158890 | 23526 | None | 2 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 404 | 8 | 2 | 4 | 2.8 | CC(C)(C)c1ccc(OCCC(=O)NCCc2ccc(S(N)(=O)=O)cc2)cc1 | nan | |||
| CHEMBL1333832 | 23526 | None | 2 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 404 | 8 | 2 | 4 | 2.8 | CC(C)(C)c1ccc(OCCC(=O)NCCc2ccc(S(N)(=O)=O)cc2)cc1 | nan | |||
| 1348329 | 26256 | None | 8 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 3 | 2 | ChEMBL | 436 | 8 | 2 | 5 | 4.4 | O=C(CCCN1C(=O)S/C(=C\C=C\c2ccccc2)C1=O)Nc1ccc(C(=O)O)cc1 | nan | |||
| CHEMBL1357976 | 26256 | None | 8 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 3 | 2 | ChEMBL | 436 | 8 | 2 | 5 | 4.4 | O=C(CCCN1C(=O)S/C(=C\C=C\c2ccccc2)C1=O)Nc1ccc(C(=O)O)cc1 | nan | |||
| 456214 | 87380 | None | 43 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -776 | 6 | ChEMBL | 388 | 7 | 3 | 7 | 4.2 | CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1 | 10.6019/CHEMBL5442687 | |||
| CHEMBL23327 | 87380 | None | 43 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -776 | 6 | ChEMBL | 388 | 7 | 3 | 7 | 4.2 | CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1 | 10.6019/CHEMBL5442687 | |||
| 3804843 | 42260 | None | 5 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 321 | 1 | 1 | 6 | 2.1 | CN1CC=C2C(C#N)=C(N)C(C#N)(C#N)C(c3ccsc3)C2C1 | nan | |||
| CHEMBL1497386 | 42260 | None | 5 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 321 | 1 | 1 | 6 | 2.1 | CN1CC=C2C(C#N)=C(N)C(C#N)(C#N)C(c3ccsc3)C2C1 | nan | |||
| 18158890 | 23526 | None | 2 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 404 | 8 | 2 | 4 | 2.8 | CC(C)(C)c1ccc(OCCC(=O)NCCc2ccc(S(N)(=O)=O)cc2)cc1 | nan | |||
| CHEMBL1333832 | 23526 | None | 2 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 404 | 8 | 2 | 4 | 2.8 | CC(C)(C)c1ccc(OCCC(=O)NCCc2ccc(S(N)(=O)=O)cc2)cc1 | nan | |||
| 4659569 | 22338 | None | 65 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 4 | 5 | Drug Central | 273 | 3 | 2 | 5 | 2.5 | Cc1ccc(C(=O)c2cc(O)c(O)c([N+](=O)[O-])c2)cc1 | None | |||
| CHEMBL1324 | 22338 | None | 65 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 4 | 5 | Drug Central | 273 | 3 | 2 | 5 | 2.5 | Cc1ccc(C(=O)c2cc(O)c(O)c([N+](=O)[O-])c2)cc1 | None | |||
| 5281081 | 210115 | None | 57 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | Drug Central | 305 | 5 | 2 | 6 | 1.8 | CCN(CC)C(=O)/C(C#N)=C/c1cc(O)c(O)c([N+](=O)[O-])c1 | None | |||
| CHEMBL953 | 210115 | None | 57 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | Drug Central | 305 | 5 | 2 | 6 | 1.8 | CCN(CC)C(=O)/C(C#N)=C/c1cc(O)c(O)c([N+](=O)[O-])c1 | None | |||
| 2882 | 1208 | None | 41 | Mouse | Functional | pEC50 | = | 8.3 | 8.3 | -15 | 5 | Drug Central | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | None | |||
| 741 | 1208 | None | 41 | Mouse | Functional | pEC50 | = | 8.3 | 8.3 | -15 | 5 | Drug Central | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | None | |||
| 7608 | 1208 | None | 41 | Mouse | Functional | pEC50 | = | 8.3 | 8.3 | -15 | 5 | Drug Central | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | None | |||
| CHEMBL428880 | 1208 | None | 41 | Mouse | Functional | pEC50 | = | 8.3 | 8.3 | -15 | 5 | Drug Central | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | None | |||
| DB01003 | 1208 | None | 41 | Mouse | Functional | pEC50 | = | 8.3 | 8.3 | -15 | 5 | Drug Central | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | None | |||
| 2161 | 8735 | None | 73 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 154 | 3 | Drug Central | 298 | 2 | 2 | 5 | 2.7 | CC(C)c1ccc2oc3nc(N)c(C(=O)O)cc3c(=O)c2c1 | None | |||
| CHEMBL1096 | 8735 | None | 73 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 154 | 3 | Drug Central | 298 | 2 | 2 | 5 | 2.7 | CC(C)c1ccc2oc3nc(N)c(C(=O)O)cc3c(=O)c2c1 | None | |||
| 2471 | 739 | None | 56 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 18 | 3 | Drug Central | 364 | 8 | 3 | 5 | 3.0 | CCCCNc1cc(cc(c1Oc1ccccc1)S(=O)(=O)N)C(=O)O | None | |||
| 427 | 739 | None | 56 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 18 | 3 | Drug Central | 364 | 8 | 3 | 5 | 3.0 | CCCCNc1cc(cc(c1Oc1ccccc1)S(=O)(=O)N)C(=O)O | None | |||
| 4837 | 739 | None | 56 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 18 | 3 | Drug Central | 364 | 8 | 3 | 5 | 3.0 | CCCCNc1cc(cc(c1Oc1ccccc1)S(=O)(=O)N)C(=O)O | None | |||
| CHEMBL1072 | 739 | None | 56 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 18 | 3 | Drug Central | 364 | 8 | 3 | 5 | 3.0 | CCCCNc1cc(cc(c1Oc1ccccc1)S(=O)(=O)N)C(=O)O | None | |||
| DB00887 | 739 | None | 56 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 18 | 3 | Drug Central | 364 | 8 | 3 | 5 | 3.0 | CCCCNc1cc(cc(c1Oc1ccccc1)S(=O)(=O)N)C(=O)O | None | |||
| 2882 | 1208 | None | 41 | Rat | Functional | pEC50 | = | 8.2 | 8.2 | 11 | 5 | Drug Central | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | None | |||
| 741 | 1208 | None | 41 | Rat | Functional | pEC50 | = | 8.2 | 8.2 | 11 | 5 | Drug Central | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | None | |||
| 7608 | 1208 | None | 41 | Rat | Functional | pEC50 | = | 8.2 | 8.2 | 11 | 5 | Drug Central | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | None | |||
| CHEMBL428880 | 1208 | None | 41 | Rat | Functional | pEC50 | = | 8.2 | 8.2 | 11 | 5 | Drug Central | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | None | |||
| DB01003 | 1208 | None | 41 | Rat | Functional | pEC50 | = | 8.2 | 8.2 | 11 | 5 | Drug Central | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | None | |||
| 50294 | 220204 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | Drug Central | 371 | 5 | 2 | 6 | 2.5 | CCCC1=C2N(CC)C(=CC(=O)C2=CC2=C1OC(=CC2=O)C(O)=O)C(O)=O | None | |||
| 50294.0 | 220204 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | Drug Central | 371 | 5 | 2 | 6 | 2.5 | CCCC1=C2N(CC)C(=CC(=O)C2=CC2=C1OC(=CC2=O)C(O)=O)C(O)=O | None | |||
| CHEMBL746 | 220204 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | Drug Central | 371 | 5 | 2 | 6 | 2.5 | CCCC1=C2N(CC)C(=CC(=O)C2=CC2=C1OC(=CC2=O)C(O)=O)C(O)=O | None | |||
| DB00716 | 220204 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | Drug Central | 371 | 5 | 2 | 6 | 2.5 | CCCC1=C2N(CC)C(=CC(=O)C2=CC2=C1OC(=CC2=O)C(O)=O)C(O)=O | None | |||
| 3325 | 2338 | None | 44 | Human | Functional | pEC50 | = | 8.1 | 8.1 | 12 | 2 | Drug Central | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | None | |||
| 44564 | 2338 | None | 44 | Human | Functional | pEC50 | = | 8.1 | 8.1 | 12 | 2 | Drug Central | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | None | |||
| 9743 | 2338 | None | 44 | Human | Functional | pEC50 | = | 8.1 | 8.1 | 12 | 2 | Drug Central | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | None | |||
| CHEMBL1201266 | 2338 | None | 44 | Human | Functional | pEC50 | = | 8.1 | 8.1 | 12 | 2 | Drug Central | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | None | |||
| DB06794 | 2338 | None | 44 | Human | Functional | pEC50 | = | 8.1 | 8.1 | 12 | 2 | Drug Central | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | None | |||
| 3325 | 2338 | None | 44 | Human | Functional | pEC50 | = | 9 | 9.0 | 12 | 2 | Guide to Pharmacology | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 29068046 | |||
| 44564 | 2338 | None | 44 | Human | Functional | pEC50 | = | 9 | 9.0 | 12 | 2 | Guide to Pharmacology | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 29068046 | |||
| 9743 | 2338 | None | 44 | Human | Functional | pEC50 | = | 9 | 9.0 | 12 | 2 | Guide to Pharmacology | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 29068046 | |||
| CHEMBL1201266 | 2338 | None | 44 | Human | Functional | pEC50 | = | 9 | 9.0 | 12 | 2 | Guide to Pharmacology | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 29068046 | |||
| DB06794 | 2338 | None | 44 | Human | Functional | pEC50 | = | 9 | 9.0 | 12 | 2 | Guide to Pharmacology | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 29068046 | |||
| 2918 | 2204 | None | 75 | Human | Functional | pEC50 | = | 4.2 | 4.2 | -2630 | 4 | Guide to Pharmacology | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 16754668 | |||
| 2918 | 2204 | None | 75 | Human | Functional | pEC50 | = | 4.2 | 4.2 | -2630 | 4 | Guide to Pharmacology | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 23396314 | |||
| 3845 | 2204 | None | 75 | Human | Functional | pEC50 | = | 4.2 | 4.2 | -2630 | 4 | Guide to Pharmacology | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 16754668 | |||
| 3845 | 2204 | None | 75 | Human | Functional | pEC50 | = | 4.2 | 4.2 | -2630 | 4 | Guide to Pharmacology | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 23396314 | |||
| CHEMBL299155 | 2204 | None | 75 | Human | Functional | pEC50 | = | 4.2 | 4.2 | -2630 | 4 | Guide to Pharmacology | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 16754668 | |||
| CHEMBL299155 | 2204 | None | 75 | Human | Functional | pEC50 | = | 4.2 | 4.2 | -2630 | 4 | Guide to Pharmacology | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 23396314 | |||
| DB11937 | 2204 | None | 75 | Human | Functional | pEC50 | = | 4.2 | 4.2 | -2630 | 4 | Guide to Pharmacology | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 16754668 | |||
| DB11937 | 2204 | None | 75 | Human | Functional | pEC50 | = | 4.2 | 4.2 | -2630 | 4 | Guide to Pharmacology | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 23396314 | |||
| 2471 | 739 | None | 56 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 18 | 3 | Guide to Pharmacology | 364 | 8 | 3 | 5 | 3.0 | CCCCNc1cc(cc(c1Oc1ccccc1)S(=O)(=O)N)C(=O)O | 22236570 | |||
| 427 | 739 | None | 56 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 18 | 3 | Guide to Pharmacology | 364 | 8 | 3 | 5 | 3.0 | CCCCNc1cc(cc(c1Oc1ccccc1)S(=O)(=O)N)C(=O)O | 22236570 | |||
| 4837 | 739 | None | 56 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 18 | 3 | Guide to Pharmacology | 364 | 8 | 3 | 5 | 3.0 | CCCCNc1cc(cc(c1Oc1ccccc1)S(=O)(=O)N)C(=O)O | 22236570 | |||
| CHEMBL1072 | 739 | None | 56 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 18 | 3 | Guide to Pharmacology | 364 | 8 | 3 | 5 | 3.0 | CCCCNc1cc(cc(c1Oc1ccccc1)S(=O)(=O)N)C(=O)O | 22236570 | |||
| DB00887 | 739 | None | 56 | Human | Functional | pEC50 | = | 5.3 | 5.3 | 18 | 3 | Guide to Pharmacology | 364 | 8 | 3 | 5 | 3.0 | CCCCNc1cc(cc(c1Oc1ccccc1)S(=O)(=O)N)C(=O)O | 22236570 | |||
| 118985385 | 1701 | None | 63 | Human | Functional | pEC50 | = | 5.4 | 5.4 | 7 | 2 | Guide to Pharmacology | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 22236570 | |||
| 1258 | 1701 | None | 63 | Human | Functional | pEC50 | = | 5.4 | 5.4 | 7 | 2 | Guide to Pharmacology | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 22236570 | |||
| 3440 | 1701 | None | 63 | Human | Functional | pEC50 | = | 5.4 | 5.4 | 7 | 2 | Guide to Pharmacology | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 22236570 | |||
| 4839 | 1701 | None | 63 | Human | Functional | pEC50 | = | 5.4 | 5.4 | 7 | 2 | Guide to Pharmacology | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 22236570 | |||
| CHEMBL35 | 1701 | None | 63 | Human | Functional | pEC50 | = | 5.4 | 5.4 | 7 | 2 | Guide to Pharmacology | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 22236570 | |||
| DB00695 | 1701 | None | 63 | Human | Functional | pEC50 | = | 5.4 | 5.4 | 7 | 2 | Guide to Pharmacology | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 22236570 | |||
| 2936 | 85 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -3 | 4 | Guide to Pharmacology | 436 | 20 | 3 | 5 | 5.0 | CCCCCCCC/C=C\CCCCCCCC(=O)OC(COP(=O)(O)O)CO | 20361937 | |||
| 56947016 | 85 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -3 | 4 | Guide to Pharmacology | 436 | 20 | 3 | 5 | 5.0 | CCCCCCCC/C=C\CCCCCCCC(=O)OC(COP(=O)(O)O)CO | 20361937 | |||
| 2920 | 2997 | None | 64 | Rat | Functional | pEC50 | None | 4 | 4.0 | -2398 | 2 | Guide to Pharmacology | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 20919992 | |||
| 54742459 | 2997 | None | 64 | Rat | Functional | pEC50 | None | 4 | 4.0 | -2398 | 2 | Guide to Pharmacology | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 20919992 | |||
| 8546 | 2997 | None | 64 | Rat | Functional | pEC50 | None | 4 | 4.0 | -2398 | 2 | Guide to Pharmacology | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 20919992 | |||
| CHEMBL177880 | 2997 | None | 64 | Rat | Functional | pEC50 | None | 4 | 4.0 | -2398 | 2 | Guide to Pharmacology | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 20919992 | |||
| 2918 | 2204 | None | 75 | Mouse | Functional | pEC50 | None | 5.0 | 5.0 | -616 | 4 | Guide to Pharmacology | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 16754668 | |||
| 3845 | 2204 | None | 75 | Mouse | Functional | pEC50 | None | 5.0 | 5.0 | -616 | 4 | Guide to Pharmacology | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 16754668 | |||
| CHEMBL299155 | 2204 | None | 75 | Mouse | Functional | pEC50 | None | 5.0 | 5.0 | -616 | 4 | Guide to Pharmacology | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 16754668 | |||
| DB11937 | 2204 | None | 75 | Mouse | Functional | pEC50 | None | 5.0 | 5.0 | -616 | 4 | Guide to Pharmacology | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 16754668 | |||
| 2918 | 2204 | None | 75 | Rat | Functional | pEC50 | None | 5.2 | 5.2 | -1202 | 4 | Guide to Pharmacology | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 16754668 | |||
| 3845 | 2204 | None | 75 | Rat | Functional | pEC50 | None | 5.2 | 5.2 | -1202 | 4 | Guide to Pharmacology | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 16754668 | |||
| CHEMBL299155 | 2204 | None | 75 | Rat | Functional | pEC50 | None | 5.2 | 5.2 | -1202 | 4 | Guide to Pharmacology | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 16754668 | |||
| DB11937 | 2204 | None | 75 | Rat | Functional | pEC50 | None | 5.2 | 5.2 | -1202 | 4 | Guide to Pharmacology | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 16754668 | |||
| 135399235 | 4134 | None | 41 | Human | Functional | pEC50 | None | 6.1 | 6.1 | -18 | 3 | Guide to Pharmacology | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 16934253 | |||
| 2919 | 4134 | None | 41 | Human | Functional | pEC50 | None | 6.1 | 6.1 | -18 | 3 | Guide to Pharmacology | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 16934253 | |||
| 5722 | 4134 | None | 41 | Human | Functional | pEC50 | None | 6.1 | 6.1 | -18 | 3 | Guide to Pharmacology | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 16934253 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Functional | pEC50 | None | 6.1 | 6.1 | -18 | 3 | Guide to Pharmacology | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 16934253 | |||
| 2920 | 2997 | None | 64 | Human | Functional | pEC50 | None | 7.3 | 7.3 | 2398 | 2 | Guide to Pharmacology | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 20919992 | |||
| 54742459 | 2997 | None | 64 | Human | Functional | pEC50 | None | 7.3 | 7.3 | 2398 | 2 | Guide to Pharmacology | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 20919992 | |||
| 8546 | 2997 | None | 64 | Human | Functional | pEC50 | None | 7.3 | 7.3 | 2398 | 2 | Guide to Pharmacology | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 20919992 | |||
| CHEMBL177880 | 2997 | None | 64 | Human | Functional | pEC50 | None | 7.3 | 7.3 | 2398 | 2 | Guide to Pharmacology | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 20919992 | |||
| 135399235 | 4134 | None | 41 | Rat | Functional | pEC50 | None | 7.8 | 7.8 | 18 | 3 | Guide to Pharmacology | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 16934253 | |||
| 2919 | 4134 | None | 41 | Rat | Functional | pEC50 | None | 7.8 | 7.8 | 18 | 3 | Guide to Pharmacology | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 16934253 | |||
| 5722 | 4134 | None | 41 | Rat | Functional | pEC50 | None | 7.8 | 7.8 | 18 | 3 | Guide to Pharmacology | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 16934253 | |||
| CHEMBL28079 | 4134 | None | 41 | Rat | Functional | pEC50 | None | 7.8 | 7.8 | 18 | 3 | Guide to Pharmacology | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 16934253 | |||
| 5280343 | 188382 | None | 69 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -8 | 12 | Drug Central | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | |||
| CHEMBL1520590 | 188382 | None | 69 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -8 | 12 | Drug Central | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | |||
| CHEMBL50 | 188382 | None | 69 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -8 | 12 | Drug Central | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | |||
| 2745687 | 933 | None | 27 | Human | Functional | pIC50 | = | 6.7 | 6.7 | 10 | 3 | Guide to Pharmacology | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 23888932 | |||
| 9741 | 933 | None | 27 | Human | Functional | pIC50 | = | 6.7 | 6.7 | 10 | 3 | Guide to Pharmacology | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 23888932 | |||
| CHEMBL1708510 | 933 | None | 27 | Human | Functional | pIC50 | = | 6.7 | 6.7 | 10 | 3 | Guide to Pharmacology | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 23888932 | |||
| 2745687 | 933 | None | 27 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 10 | 3 | Guide to Pharmacology | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 23888932 | |||
| 9741 | 933 | None | 27 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 10 | 3 | Guide to Pharmacology | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 23888932 | |||
| CHEMBL1708510 | 933 | None | 27 | Human | Functional | pIC50 | = | 5.0 | 5.0 | 10 | 3 | Guide to Pharmacology | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 23888932 | |||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 135399235 | 4134 | None | 41 | Human | Binding | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acsmedchemlett.2c00461 | |||
| 2919 | 4134 | None | 41 | Human | Binding | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acsmedchemlett.2c00461 | |||
| 5722 | 4134 | None | 41 | Human | Binding | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Binding | pEC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acsmedchemlett.2c00461 | |||
| 12138435 | 68079 | None | 26 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 329 | 1 | 0 | 4 | 4.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL1914576 | 68079 | None | 26 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 329 | 1 | 0 | 4 | 4.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1 | 10.1021/acs.jmedchem.6b01431 | |||
| 71733650 | 90877 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(F)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm400587g | |||
| CHEMBL2392161 | 90877 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(F)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm400587g | |||
| 694463 | 87514 | None | 63 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 268 | 1 | 1 | 3 | 2.3 | O=C(O)c1cc2cc(Br)ccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL2333943 | 87514 | None | 63 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 268 | 1 | 1 | 3 | 2.3 | O=C(O)c1cc2cc(Br)ccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 71733848 | 90895 | None | 0 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 451 | 4 | 2 | 5 | 4.2 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(Cl)c1 | 10.1021/jm4009373 | |||
| CHEMBL2392179 | 90895 | None | 0 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 451 | 4 | 2 | 5 | 4.2 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(Cl)c1 | 10.1021/jm4009373 | |||
| 71733848 | 90895 | None | 0 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 451 | 4 | 2 | 5 | 4.2 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(Cl)c1 | 10.1021/jm400587g | |||
| CHEMBL2392179 | 90895 | None | 0 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 451 | 4 | 2 | 5 | 4.2 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(Cl)c1 | 10.1021/jm400587g | |||
| 71733848 | 90895 | None | 0 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 451 | 4 | 2 | 5 | 4.2 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(Cl)c1 | 10.1021/jm400587g | |||
| CHEMBL2392179 | 90895 | None | 0 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 451 | 4 | 2 | 5 | 4.2 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(Cl)c1 | 10.1021/jm400587g | |||
| 135399235 | 4134 | None | 41 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1039/C2MD20210G | |||
| 2919 | 4134 | None | 41 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1039/C2MD20210G | |||
| 5722 | 4134 | None | 41 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1039/C2MD20210G | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1039/C2MD20210G | |||
| 71733845 | 90892 | None | 0 | Rat | Binding | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccccc1C(=O)Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| CHEMBL2392176 | 90892 | None | 0 | Rat | Binding | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccccc1C(=O)Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| 4488 | 205479 | None | 66 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | 10.1021/jm4009373 | |||
| CHEMBL63323 | 205479 | None | 66 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | 10.1021/jm4009373 | |||
| 71733651 | 90878 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 357 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(F)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392162 | 90878 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 357 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(F)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 71733651 | 90878 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 357 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(F)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392162 | 90878 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 357 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(F)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 71734940 | 90879 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 385 | 5 | 1 | 6 | 3.4 | CCOC(=O)c1cc(=O)c2cc(F)cc(NC(=O)c3ccc(OC)cc3)c2o1 | 10.1021/jm400587g | |||
| CHEMBL2392163 | 90879 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 385 | 5 | 1 | 6 | 3.4 | CCOC(=O)c1cc(=O)c2cc(F)cc(NC(=O)c3ccc(OC)cc3)c2o1 | 10.1021/jm400587g | |||
| 118985385 | 1701 | None | 63 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | |||
| 1258 | 1701 | None | 63 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | |||
| 3440 | 1701 | None | 63 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | |||
| 4839 | 1701 | None | 63 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | |||
| CHEMBL35 | 1701 | None | 63 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | |||
| DB00695 | 1701 | None | 63 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | |||
| 71733650 | 90877 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(F)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm400587g | |||
| CHEMBL2392161 | 90877 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(F)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm400587g | |||
| 71733843 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392174 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2425818 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 71733843 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392174 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2425818 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 71733843 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL2392174 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL2425818 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/acs.jmedchem.6b01431 | |||
| 2920 | 2997 | None | 64 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm4009373 | |||
| 54742459 | 2997 | None | 64 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm4009373 | |||
| 8546 | 2997 | None | 64 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm4009373 | |||
| CHEMBL177880 | 2997 | None | 64 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm4009373 | |||
| 2920 | 2997 | None | 64 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 54742459 | 2997 | None | 64 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 8546 | 2997 | None | 64 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL177880 | 2997 | None | 64 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 71734944 | 90864 | None | 0 | Rat | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 315 | 3 | 2 | 4 | 3.0 | O=C(O)c1cc(=O)c2cccc(NC(=O)C3CCCCC3)c2o1 | 10.1021/jm400587g | |||
| CHEMBL2392148 | 90864 | None | 0 | Rat | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 315 | 3 | 2 | 4 | 3.0 | O=C(O)c1cc(=O)c2cccc(NC(=O)C3CCCCC3)c2o1 | 10.1021/jm400587g | |||
| 71733653 | 90881 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.7 | Cc1cccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm400587g | |||
| CHEMBL2392165 | 90881 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.7 | Cc1cccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm400587g | |||
| 2882 | 1208 | None | 41 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm400587g | |||
| 741 | 1208 | None | 41 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm400587g | |||
| 7608 | 1208 | None | 41 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm400587g | |||
| CHEMBL428880 | 1208 | None | 41 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm400587g | |||
| DB01003 | 1208 | None | 41 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm400587g | |||
| 71734939 | 90860 | None | 1 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 283 | 1 | 2 | 4 | 1.8 | Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| CHEMBL2392144 | 90860 | None | 1 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 283 | 1 | 2 | 4 | 1.8 | Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| 71733847 | 90894 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 431 | 3 | 2 | 6 | 3.2 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc2c(c1)OCO2 | 10.1021/jm400587g | |||
| CHEMBL2392178 | 90894 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 431 | 3 | 2 | 6 | 3.2 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc2c(c1)OCO2 | 10.1021/jm400587g | |||
| 92934 | 169760 | None | 56 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 280 | 2 | 2 | 6 | 1.9 | O=C(O)[C@H]1CSC(c2nc3ccc(O)cc3s2)=N1 | 10.1021/jm4009373 | |||
| CHEMBL443738 | 169760 | None | 56 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 280 | 2 | 2 | 6 | 1.9 | O=C(O)[C@H]1CSC(c2nc3ccc(O)cc3s2)=N1 | 10.1021/jm4009373 | |||
| 12403015 | 111559 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 300 | 2 | 4 | 4 | 0.8 | O=C(O)c1cc(=O)c2c(ccc3c(=O)cc(C(=O)O)[nH]c32)[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL3277775 | 111559 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 300 | 2 | 4 | 4 | 0.8 | O=C(O)c1cc(=O)c2c(ccc3c(=O)cc(C(=O)O)[nH]c32)[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 135399235 | 4134 | None | 41 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm4009373 | |||
| 2919 | 4134 | None | 41 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm4009373 | |||
| 5722 | 4134 | None | 41 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm4009373 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm4009373 | |||
| 54676038 | 38734 | None | 51 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 336 | 2 | 2 | 6 | 2.9 | O=c1oc2ccccc2c(O)c1Cc1c(O)c2ccccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL1466 | 38734 | None | 51 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 336 | 2 | 2 | 6 | 2.9 | O=c1oc2ccccc2c(O)c1Cc1c(O)c2ccccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 54676038 | 38734 | None | 51 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 336 | 2 | 2 | 6 | 2.9 | O=c1oc2ccccc2c(O)c1Cc1c(O)c2ccccc2oc1=O | 10.1021/jm4009373 | |||
| CHEMBL1466 | 38734 | None | 51 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 336 | 2 | 2 | 6 | 2.9 | O=c1oc2ccccc2c(O)c1Cc1c(O)c2ccccc2oc1=O | 10.1021/jm4009373 | |||
| 71733846 | 90893 | None | 0 | Rat | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 447 | 5 | 2 | 6 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1OC | 10.1021/jm400587g | |||
| CHEMBL2392177 | 90893 | None | 0 | Rat | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 447 | 5 | 2 | 6 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1OC | 10.1021/jm400587g | |||
| 71735030 | 90868 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 360 | 3 | 2 | 5 | 3.3 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccccc2n1 | 10.1021/jm4009373 | |||
| CHEMBL2392152 | 90868 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 360 | 3 | 2 | 5 | 3.3 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccccc2n1 | 10.1021/jm4009373 | |||
| 71735030 | 90868 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 360 | 3 | 2 | 5 | 3.3 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccccc2n1 | 10.1021/jm400587g | |||
| CHEMBL2392152 | 90868 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 360 | 3 | 2 | 5 | 3.3 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccccc2n1 | 10.1021/jm400587g | |||
| 71734942 | 90862 | None | 0 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 261 | 3 | 2 | 4 | 1.8 | CCC(=O)Nc1cccc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| CHEMBL2392146 | 90862 | None | 0 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 261 | 3 | 2 | 4 | 1.8 | CCC(=O)Nc1cccc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| 271643 | 32788 | None | 45 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 224 | 1 | 1 | 3 | 2.1 | O=C(O)c1cc2cc(Cl)ccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL1414071 | 32788 | None | 45 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 224 | 1 | 1 | 3 | 2.1 | O=C(O)c1cc2cc(Cl)ccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 71733844 | 90891 | None | 0 | Rat | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 431 | 5 | 2 | 5 | 3.9 | CCOc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392175 | 90891 | None | 0 | Rat | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 431 | 5 | 2 | 5 | 3.9 | CCOc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 71735034 | 90871 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 323 | 3 | 2 | 4 | 3.1 | Cc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392155 | 90871 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 323 | 3 | 2 | 4 | 3.1 | Cc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 10857978 | 115309 | None | 5 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 252 | 2 | 1 | 5 | 2.5 | O=[N+]([O-])c1cc([N+](=O)[O-])c(Cl)c(Cl)c1O | 10.1039/C2MD20210G | |||
| CHEMBL3347429 | 115309 | None | 5 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 252 | 2 | 1 | 5 | 2.5 | O=[N+]([O-])c1cc([N+](=O)[O-])c(Cl)c(Cl)c1O | 10.1039/C2MD20210G | |||
| 137652009 | 157606 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 320 | 3 | 2 | 10 | 0.5 | O=c1oc2c([N+](=O)[O-])c(O)c([N+](=O)[O-])cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4079816 | 157606 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 320 | 3 | 2 | 10 | 0.5 | O=c1oc2c([N+](=O)[O-])c(O)c([N+](=O)[O-])cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 137652009 | 157606 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 320 | 3 | 2 | 10 | 0.5 | O=c1oc2c([N+](=O)[O-])c(O)c([N+](=O)[O-])cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4079816 | 157606 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 320 | 3 | 2 | 10 | 0.5 | O=c1oc2c([N+](=O)[O-])c(O)c([N+](=O)[O-])cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 71733848 | 90895 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 451 | 4 | 2 | 5 | 4.2 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(Cl)c1 | 10.1021/jm400587g | |||
| CHEMBL2392179 | 90895 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 451 | 4 | 2 | 5 | 4.2 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(Cl)c1 | 10.1021/jm400587g | |||
| 2295463 | 92255 | None | 29 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 279 | 4 | 2 | 5 | 1.5 | O=C(O)COc1ccc(/C=C2\SC(=O)NC2=O)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2425825 | 92255 | None | 29 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 279 | 4 | 2 | 5 | 1.5 | O=C(O)COc1ccc(/C=C2\SC(=O)NC2=O)cc1 | 10.1021/jm4009373 | |||
| 71733843 | 90890 | None | 7 | Rat | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392174 | 90890 | None | 7 | Rat | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2425818 | 90890 | None | 7 | Rat | Binding | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 137657450 | 159689 | None | 4 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 400 | 2 | 1 | 6 | 2.5 | COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1Br | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4103143 | 159689 | None | 4 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 400 | 2 | 1 | 6 | 2.5 | COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1Br | 10.1021/acs.jmedchem.6b01431 | |||
| 137657450 | 159689 | None | 4 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 400 | 2 | 1 | 6 | 2.5 | COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1Br | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4103143 | 159689 | None | 4 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 400 | 2 | 1 | 6 | 2.5 | COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1Br | 10.1021/acs.jmedchem.6b01431 | |||
| 137657450 | 159689 | None | 4 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 400 | 2 | 1 | 6 | 2.5 | COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1Br | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4103143 | 159689 | None | 4 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 400 | 2 | 1 | 6 | 2.5 | COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1Br | 10.1021/acs.jmedchem.6b01431 | |||
| 71733651 | 90878 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 357 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(F)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392162 | 90878 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 357 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(F)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 71733939 | 90898 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 418 | 4 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)nc1 | 10.1021/jm400587g | |||
| CHEMBL2392182 | 90898 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 418 | 4 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)nc1 | 10.1021/jm400587g | |||
| 137636652 | 156140 | None | 4 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 322 | 2 | 1 | 6 | 1.7 | COc1cc2oc(=O)c(-c3nnn[nH]3)cc2cc1Br | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4062531 | 156140 | None | 4 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 322 | 2 | 1 | 6 | 1.7 | COc1cc2oc(=O)c(-c3nnn[nH]3)cc2cc1Br | 10.1021/acs.jmedchem.6b01431 | |||
| 13950958 | 157720 | None | 4 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 362 | 1 | 2 | 4 | 2.7 | O=C(O)c1cc2cc(Br)c(O)c(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4081238 | 157720 | None | 4 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 362 | 1 | 2 | 4 | 2.7 | O=C(O)c1cc2cc(Br)c(O)c(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 71733749 | 90888 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm400587g | |||
| CHEMBL2392172 | 90888 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm400587g | |||
| 71733749 | 90888 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm400587g | |||
| CHEMBL2392172 | 90888 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm400587g | |||
| 13950958 | 157720 | None | 4 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 362 | 1 | 2 | 4 | 2.7 | O=C(O)c1cc2cc(Br)c(O)c(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4081238 | 157720 | None | 4 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 362 | 1 | 2 | 4 | 2.7 | O=C(O)c1cc2cc(Br)c(O)c(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 4488 | 205479 | None | 66 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | 10.1021/jm4009373 | |||
| CHEMBL63323 | 205479 | None | 66 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | 10.1021/jm4009373 | |||
| 137653726 | 158768 | None | 4 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 386 | 1 | 2 | 6 | 2.2 | O=c1oc2c(Br)c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4092954 | 158768 | None | 4 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 386 | 1 | 2 | 6 | 2.2 | O=c1oc2c(Br)c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 71733939 | 90898 | None | 0 | Rat | Binding | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 418 | 4 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)nc1 | 10.1021/jm400587g | |||
| CHEMBL2392182 | 90898 | None | 0 | Rat | Binding | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 418 | 4 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)nc1 | 10.1021/jm400587g | |||
| 71735035 | 90872 | None | 0 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.8 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc(C(F)(F)F)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392156 | 90872 | None | 0 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.8 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc(C(F)(F)F)cc1 | 10.1021/jm400587g | |||
| 71733748 | 90887 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | 10.1021/jm400587g | |||
| CHEMBL2392171 | 90887 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | 10.1021/jm400587g | |||
| 71733748 | 90887 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | 10.1021/jm4009373 | |||
| CHEMBL2392171 | 90887 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | 10.1021/jm4009373 | |||
| 71733748 | 90887 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | 10.1021/jm400587g | |||
| CHEMBL2392171 | 90887 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | 10.1021/jm400587g | |||
| 71733744 | 90883 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 3.4 | COc1ccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392167 | 90883 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 3.4 | COc1ccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 71733744 | 90883 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 3.4 | COc1ccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392167 | 90883 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 3.4 | COc1ccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 71733649 | 90876 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(O)c1cc(=O)c2cc(F)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | 10.1021/jm400587g | |||
| CHEMBL2392160 | 90876 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(O)c1cc(=O)c2cc(F)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | 10.1021/jm400587g | |||
| 71733744 | 90883 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 3.4 | COc1ccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392167 | 90883 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 3.4 | COc1ccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 135399235 | 4134 | None | 41 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.6b01431 | |||
| 2919 | 4134 | None | 41 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.6b01431 | |||
| 5722 | 4134 | None | 41 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.6b01431 | |||
| 71733845 | 90892 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccccc1C(=O)Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| CHEMBL2392176 | 90892 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccccc1C(=O)Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| 71733845 | 90892 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccccc1C(=O)Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| CHEMBL2392176 | 90892 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccccc1C(=O)Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| 71733649 | 90876 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(O)c1cc(=O)c2cc(F)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | 10.1021/jm400587g | |||
| CHEMBL2392160 | 90876 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(O)c1cc(=O)c2cc(F)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | 10.1021/jm400587g | |||
| 135468531 | 90858 | None | 19 | Mouse | Binding | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 342 | 3 | 2 | 4 | 3.4 | O=C1N/C(=N/c2ccccc2F)S/C1=C\c1ccc(C(=O)O)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392141 | 90858 | None | 19 | Mouse | Binding | pEC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 342 | 3 | 2 | 4 | 3.4 | O=C1N/C(=N/c2ccccc2F)S/C1=C\c1ccc(C(=O)O)cc1 | 10.1021/jm400587g | |||
| 71733743 | 90882 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 388 | 4 | 2 | 6 | 3.3 | O=C(Nc1cc(Cl)cc2c(=O)cc(C(=O)O)oc12)c1ccc([N+](=O)[O-])cc1 | 10.1021/jm400587g | |||
| CHEMBL2392166 | 90882 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 388 | 4 | 2 | 6 | 3.3 | O=C(Nc1cc(Cl)cc2c(=O)cc(C(=O)O)oc12)c1ccc([N+](=O)[O-])cc1 | 10.1021/jm400587g | |||
| 5464105 | 57849 | None | 47 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 265 | 4 | 2 | 6 | 1.6 | CC(=O)C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)C(C)=O | 10.1039/C2MD20210G | |||
| CHEMBL167055 | 57849 | None | 47 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 265 | 4 | 2 | 6 | 1.6 | CC(=O)C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)C(C)=O | 10.1039/C2MD20210G | |||
| 725495 | 65557 | None | 43 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 346 | 1 | 1 | 3 | 3.0 | O=C(O)c1cc2cc(Br)cc(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL1830823 | 65557 | None | 43 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 346 | 1 | 1 | 3 | 3.0 | O=C(O)c1cc2cc(Br)cc(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 725495 | 65557 | None | 43 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 346 | 1 | 1 | 3 | 3.0 | O=C(O)c1cc2cc(Br)cc(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL1830823 | 65557 | None | 43 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 346 | 1 | 1 | 3 | 3.0 | O=C(O)c1cc2cc(Br)cc(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 71733651 | 90878 | None | 0 | Rat | Binding | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 357 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(F)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392162 | 90878 | None | 0 | Rat | Binding | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 357 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(F)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 137655259 | 159060 | None | 4 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 327 | 0 | 0 | 3 | 3.2 | N#Cc1cc2cc(Br)cc(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4096105 | 159060 | None | 4 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 327 | 0 | 0 | 3 | 3.2 | N#Cc1cc2cc(Br)cc(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 11312 | 111581 | None | 28 | Human | Binding | pEC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 184 | 2 | 1 | 5 | 1.2 | O=[N+]([O-])c1cccc([N+](=O)[O-])c1O | 10.1039/C2MD20210G | |||
| CHEMBL3278560 | 111581 | None | 28 | Human | Binding | pEC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 184 | 2 | 1 | 5 | 1.2 | O=[N+]([O-])c1cccc([N+](=O)[O-])c1O | 10.1039/C2MD20210G | |||
| 71733744 | 90883 | None | 0 | Rat | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 3.4 | COc1ccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392167 | 90883 | None | 0 | Rat | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 3.4 | COc1ccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 4921319 | 107517 | None | 34 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 199 | 2 | 2 | 6 | 0.8 | Nc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1O | 10.1039/C2MD20210G | |||
| CHEMBL3183248 | 107517 | None | 34 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 199 | 2 | 2 | 6 | 0.8 | Nc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1O | 10.1039/C2MD20210G | |||
| 135399235 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm400587g | |||
| 2919 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm400587g | |||
| 5722 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm400587g | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm400587g | |||
| 137662152 | 159485 | None | 11 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 353 | 2 | 2 | 8 | 1.3 | O=c1oc2c([N+](=O)[O-])c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4100677 | 159485 | None | 11 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 353 | 2 | 2 | 8 | 1.3 | O=c1oc2c([N+](=O)[O-])c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 2920 | 2997 | None | 64 | Human | Binding | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acs.jmedchem.6b01431 | |||
| 54742459 | 2997 | None | 64 | Human | Binding | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acs.jmedchem.6b01431 | |||
| 8546 | 2997 | None | 64 | Human | Binding | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL177880 | 2997 | None | 64 | Human | Binding | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acs.jmedchem.6b01431 | |||
| 2920 | 2997 | None | 64 | Human | Binding | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm4009373 | |||
| 54742459 | 2997 | None | 64 | Human | Binding | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm4009373 | |||
| 8546 | 2997 | None | 64 | Human | Binding | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm4009373 | |||
| CHEMBL177880 | 2997 | None | 64 | Human | Binding | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm4009373 | |||
| 71733649 | 90876 | None | 0 | Human | Binding | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(O)c1cc(=O)c2cc(F)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | 10.1021/jm400587g | |||
| CHEMBL2392160 | 90876 | None | 0 | Human | Binding | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(O)c1cc(=O)c2cc(F)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | 10.1021/jm400587g | |||
| 657910 | 53468 | None | 35 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 258 | 1 | 1 | 3 | 2.8 | O=C(O)c1cc2cc(Cl)cc(Cl)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL1600989 | 53468 | None | 35 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 258 | 1 | 1 | 3 | 2.8 | O=C(O)c1cc2cc(Cl)cc(Cl)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 71734943 | 90863 | None | 0 | Human | Binding | pEC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 305 | 4 | 2 | 6 | 1.0 | COC(=O)CC(=O)Nc1cccc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| CHEMBL2392147 | 90863 | None | 0 | Human | Binding | pEC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 305 | 4 | 2 | 6 | 1.0 | COC(=O)CC(=O)Nc1cccc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| 71733847 | 90894 | None | 0 | Rat | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 431 | 3 | 2 | 6 | 3.2 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc2c(c1)OCO2 | 10.1021/jm400587g | |||
| CHEMBL2392178 | 90894 | None | 0 | Rat | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 431 | 3 | 2 | 6 | 3.2 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc2c(c1)OCO2 | 10.1021/jm400587g | |||
| 71733746 | 90885 | None | 0 | Rat | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 401 | 3 | 2 | 4 | 3.8 | Cc1cccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm400587g | |||
| CHEMBL2392169 | 90885 | None | 0 | Rat | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 401 | 3 | 2 | 4 | 3.8 | Cc1cccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm400587g | |||
| 2882 | 1208 | None | 41 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm4009373 | |||
| 741 | 1208 | None | 41 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm4009373 | |||
| 7608 | 1208 | None | 41 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm4009373 | |||
| CHEMBL428880 | 1208 | None | 41 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm4009373 | |||
| DB01003 | 1208 | None | 41 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm4009373 | |||
| 71733653 | 90881 | None | 0 | Rat | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.7 | Cc1cccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm400587g | |||
| CHEMBL2392165 | 90881 | None | 0 | Rat | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.7 | Cc1cccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm400587g | |||
| 3254949 | 115310 | None | 3 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 460 | 6 | 2 | 10 | 3.9 | O=[N+]([O-])c1cc(C(=C(Cl)Cl)c2cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c2)cc([N+](=O)[O-])c1O | 10.1039/C2MD20210G | |||
| CHEMBL3347474 | 115310 | None | 3 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 460 | 6 | 2 | 10 | 3.9 | O=[N+]([O-])c1cc(C(=C(Cl)Cl)c2cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c2)cc([N+](=O)[O-])c1O | 10.1039/C2MD20210G | |||
| 782693 | 158333 | None | 19 | Human | Binding | pEC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 205 | 0 | 0 | 3 | 2.3 | N#Cc1cc2cc(Cl)ccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4088382 | 158333 | None | 19 | Human | Binding | pEC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 205 | 0 | 0 | 3 | 2.3 | N#Cc1cc2cc(Cl)ccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 71735036 | 90873 | None | 0 | Rat | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 339 | 4 | 2 | 5 | 2.8 | COc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392157 | 90873 | None | 0 | Rat | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 339 | 4 | 2 | 5 | 2.8 | COc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 71733843 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392174 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2425818 | 90890 | None | 7 | Human | Binding | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 3870203 | 58347 | None | 41 | Human | Binding | pEC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 200 | 2 | 2 | 6 | 0.9 | O=[N+]([O-])c1cc(O)c(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| CHEMBL168276 | 58347 | None | 41 | Human | Binding | pEC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 200 | 2 | 2 | 6 | 0.9 | O=[N+]([O-])c1cc(O)c(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| 135399235 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm400587g | |||
| 2919 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm400587g | |||
| 5722 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm400587g | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm400587g | |||
| 71733842 | 90889 | None | 0 | Rat | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 412 | 3 | 2 | 5 | 3.4 | N#Cc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392173 | 90889 | None | 0 | Rat | Binding | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 412 | 3 | 2 | 5 | 3.4 | N#Cc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 137658268 | 159756 | None | 4 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 343 | 0 | 1 | 4 | 2.9 | N#Cc1cc2cc(Br)c(O)c(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4103860 | 159756 | None | 4 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 343 | 0 | 1 | 4 | 2.9 | N#Cc1cc2cc(Br)c(O)c(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 137658268 | 159756 | None | 4 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 343 | 0 | 1 | 4 | 2.9 | N#Cc1cc2cc(Br)c(O)c(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4103860 | 159756 | None | 4 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 343 | 0 | 1 | 4 | 2.9 | N#Cc1cc2cc(Br)c(O)c(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 633803 | 115311 | None | 8 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 408 | 6 | 2 | 10 | 3.1 | CC(C)(c1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)c1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| CHEMBL3347475 | 115311 | None | 8 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 408 | 6 | 2 | 10 | 3.1 | CC(C)(c1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)c1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| 71734941 | 90861 | None | 0 | Human | Binding | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 247 | 2 | 2 | 4 | 1.5 | CC(=O)Nc1cccc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| CHEMBL2392145 | 90861 | None | 0 | Human | Binding | pEC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 247 | 2 | 2 | 4 | 1.5 | CC(=O)Nc1cccc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| 10857978 | 115309 | None | 5 | Human | Binding | pEC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 252 | 2 | 1 | 5 | 2.5 | O=[N+]([O-])c1cc([N+](=O)[O-])c(Cl)c(Cl)c1O | 10.1039/C2MD20210G | |||
| CHEMBL3347429 | 115309 | None | 5 | Human | Binding | pEC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 252 | 2 | 1 | 5 | 2.5 | O=[N+]([O-])c1cc([N+](=O)[O-])c(Cl)c(Cl)c1O | 10.1039/C2MD20210G | |||
| 71733747 | 90886 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 421 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392170 | 90886 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 421 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)cc1 | 10.1021/jm4009373 | |||
| 71733749 | 90888 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm4009373 | |||
| CHEMBL2392172 | 90888 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm4009373 | |||
| 71733747 | 90886 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 421 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392170 | 90886 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 421 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)cc1 | 10.1021/jm400587g | |||
| 73294510 | 92253 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 369 | 5 | 2 | 6 | 2.8 | COc1ccc(C(=O)Nc2cc(OC)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2425823 | 92253 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 369 | 5 | 2 | 6 | 2.8 | COc1ccc(C(=O)Nc2cc(OC)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 135468531 | 90858 | None | 19 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 342 | 3 | 2 | 4 | 3.4 | O=C1N/C(=N/c2ccccc2F)S/C1=C\c1ccc(C(=O)O)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392141 | 90858 | None | 19 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 342 | 3 | 2 | 4 | 3.4 | O=C1N/C(=N/c2ccccc2F)S/C1=C\c1ccc(C(=O)O)cc1 | 10.1021/jm400587g | |||
| 135468531 | 90858 | None | 19 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 342 | 3 | 2 | 4 | 3.4 | O=C1N/C(=N/c2ccccc2F)S/C1=C\c1ccc(C(=O)O)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392141 | 90858 | None | 19 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 342 | 3 | 2 | 4 | 3.4 | O=C1N/C(=N/c2ccccc2F)S/C1=C\c1ccc(C(=O)O)cc1 | 10.1021/jm400587g | |||
| 71733650 | 90877 | None | 0 | Rat | Binding | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(F)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm400587g | |||
| CHEMBL2392161 | 90877 | None | 0 | Rat | Binding | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(F)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm400587g | |||
| 137646097 | 157992 | None | 4 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 367 | 3 | 1 | 8 | 1.7 | COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1[N+](=O)[O-] | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4084237 | 157992 | None | 4 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 367 | 3 | 1 | 8 | 1.7 | COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1[N+](=O)[O-] | 10.1021/acs.jmedchem.6b01431 | |||
| 71733749 | 90888 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm400587g | |||
| CHEMBL2392172 | 90888 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm400587g | |||
| 71735032 | 90869 | None | 0 | Rat | Binding | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 323 | 3 | 2 | 4 | 3.1 | Cc1cccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm400587g | |||
| CHEMBL2392153 | 90869 | None | 0 | Rat | Binding | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 323 | 3 | 2 | 4 | 3.1 | Cc1cccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm400587g | |||
| 71733745 | 90884 | None | 0 | Rat | Binding | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 387 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm400587g | |||
| CHEMBL2392168 | 90884 | None | 0 | Rat | Binding | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 387 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm400587g | |||
| 71733744 | 90883 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 3.4 | COc1ccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392167 | 90883 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 3.4 | COc1ccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 71733652 | 90880 | None | 0 | Rat | Binding | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 343 | 3 | 2 | 4 | 3.4 | O=C(Nc1cc(Cl)cc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm400587g | |||
| CHEMBL2392164 | 90880 | None | 0 | Rat | Binding | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 343 | 3 | 2 | 4 | 3.4 | O=C(Nc1cc(Cl)cc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm400587g | |||
| 137652009 | 157606 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 320 | 3 | 2 | 10 | 0.5 | O=c1oc2c([N+](=O)[O-])c(O)c([N+](=O)[O-])cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4079816 | 157606 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 320 | 3 | 2 | 10 | 0.5 | O=c1oc2c([N+](=O)[O-])c(O)c([N+](=O)[O-])cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 137647862 | 157745 | None | 4 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 324 | 2 | 0 | 6 | 2.3 | COc1c(Br)cc2cc(C#N)c(=O)oc2c1[N+](=O)[O-] | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4081445 | 157745 | None | 4 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 324 | 2 | 0 | 6 | 2.3 | COc1c(Br)cc2cc(C#N)c(=O)oc2c1[N+](=O)[O-] | 10.1021/acs.jmedchem.6b01431 | |||
| 633803 | 115311 | None | 8 | Human | Binding | pEC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 408 | 6 | 2 | 10 | 3.1 | CC(C)(c1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)c1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| CHEMBL3347475 | 115311 | None | 8 | Human | Binding | pEC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 408 | 6 | 2 | 10 | 3.1 | CC(C)(c1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)c1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| 71734946 | 90867 | None | 0 | Mouse | Binding | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 359 | 3 | 2 | 4 | 3.9 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccccc2c1 | 10.1021/jm400587g | |||
| CHEMBL2392151 | 90867 | None | 0 | Mouse | Binding | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 359 | 3 | 2 | 4 | 3.9 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccccc2c1 | 10.1021/jm400587g | |||
| 2920 | 2997 | None | 64 | Human | Binding | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 54742459 | 2997 | None | 64 | Human | Binding | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 8546 | 2997 | None | 64 | Human | Binding | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL177880 | 2997 | None | 64 | Human | Binding | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 137662152 | 159485 | None | 11 | Human | Binding | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 353 | 2 | 2 | 8 | 1.3 | O=c1oc2c([N+](=O)[O-])c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL4100677 | 159485 | None | 11 | Human | Binding | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 353 | 2 | 2 | 8 | 1.3 | O=c1oc2c([N+](=O)[O-])c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.2c00461 | |||
| 135468531 | 90858 | None | 19 | Human | Binding | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 342 | 3 | 2 | 4 | 3.4 | O=C1N/C(=N/c2ccccc2F)S/C1=C\c1ccc(C(=O)O)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392141 | 90858 | None | 19 | Human | Binding | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 342 | 3 | 2 | 4 | 3.4 | O=C1N/C(=N/c2ccccc2F)S/C1=C\c1ccc(C(=O)O)cc1 | 10.1021/jm4009373 | |||
| 71733940 | 90899 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 418 | 4 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cn1 | 10.1021/jm400587g | |||
| CHEMBL2392183 | 90899 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 418 | 4 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cn1 | 10.1021/jm400587g | |||
| 71733940 | 90899 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 418 | 4 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cn1 | 10.1021/jm400587g | |||
| CHEMBL2392183 | 90899 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 418 | 4 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cn1 | 10.1021/jm400587g | |||
| 71733745 | 90884 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 387 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm4009373 | |||
| CHEMBL2392168 | 90884 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 387 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm4009373 | |||
| 71733745 | 90884 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 387 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm400587g | |||
| CHEMBL2392168 | 90884 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 387 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm400587g | |||
| 4488 | 205479 | None | 66 | Human | Binding | pEC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | 10.1021/jm4009373 | |||
| CHEMBL63323 | 205479 | None | 66 | Human | Binding | pEC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | 10.1021/jm4009373 | |||
| 1493 | 98143 | None | 45 | Human | Binding | pEC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 184 | 2 | 1 | 5 | 1.2 | O=[N+]([O-])c1ccc(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| CHEMBL273386 | 98143 | None | 45 | Human | Binding | pEC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 184 | 2 | 1 | 5 | 1.2 | O=[N+]([O-])c1ccc(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| 71733648 | 90875 | None | 0 | Rat | Binding | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(O)c1cc(=O)c2cc(F)cc(NC(=O)c3cccc(Cl)c3Cl)c2o1 | 10.1021/jm400587g | |||
| CHEMBL2392159 | 90875 | None | 0 | Rat | Binding | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(O)c1cc(=O)c2cc(F)cc(NC(=O)c3cccc(Cl)c3Cl)c2o1 | 10.1021/jm400587g | |||
| 71733743 | 90882 | None | 0 | Rat | Binding | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 388 | 4 | 2 | 6 | 3.3 | O=C(Nc1cc(Cl)cc2c(=O)cc(C(=O)O)oc12)c1ccc([N+](=O)[O-])cc1 | 10.1021/jm400587g | |||
| CHEMBL2392166 | 90882 | None | 0 | Rat | Binding | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 388 | 4 | 2 | 6 | 3.3 | O=C(Nc1cc(Cl)cc2c(=O)cc(C(=O)O)oc12)c1ccc([N+](=O)[O-])cc1 | 10.1021/jm400587g | |||
| 12138435 | 68079 | None | 26 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 329 | 1 | 0 | 4 | 4.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL1914576 | 68079 | None | 26 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 329 | 1 | 0 | 4 | 4.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1 | 10.1021/acs.jmedchem.6b01431 | |||
| 135399235 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1039/C2MD20210G | |||
| 2919 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1039/C2MD20210G | |||
| 5722 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1039/C2MD20210G | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1039/C2MD20210G | |||
| 71733749 | 90888 | None | 0 | Rat | Binding | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm400587g | |||
| CHEMBL2392172 | 90888 | None | 0 | Rat | Binding | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm400587g | |||
| 137648473 | 158084 | None | 4 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 337 | 2 | 1 | 7 | 1.6 | O=c1oc2c([N+](=O)[O-])cc(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4085211 | 158084 | None | 4 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 337 | 2 | 1 | 7 | 1.6 | O=c1oc2c([N+](=O)[O-])cc(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 137648473 | 158084 | None | 4 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 337 | 2 | 1 | 7 | 1.6 | O=c1oc2c([N+](=O)[O-])cc(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4085211 | 158084 | None | 4 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 337 | 2 | 1 | 7 | 1.6 | O=c1oc2c([N+](=O)[O-])cc(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 71733748 | 90887 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | 10.1021/jm400587g | |||
| CHEMBL2392171 | 90887 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | 10.1021/jm400587g | |||
| 135399235 | 4134 | None | 41 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.6b01431 | |||
| 2919 | 4134 | None | 41 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.6b01431 | |||
| 5722 | 4134 | None | 41 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.6b01431 | |||
| 40119 | 84839 | None | 14 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 312 | 1 | 1 | 6 | 1.2 | O=C1c2ccccc2S(=O)(=O)c2cc(-c3nn[nH]n3)ccc21 | 10.1021/acsmedchemlett.7b00510 | |||
| CHEMBL22336 | 84839 | None | 14 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 312 | 1 | 1 | 6 | 1.2 | O=C1c2ccccc2S(=O)(=O)c2cc(-c3nn[nH]n3)ccc21 | 10.1021/acsmedchemlett.7b00510 | |||
| 71735036 | 90873 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 339 | 4 | 2 | 5 | 2.8 | COc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392157 | 90873 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 339 | 4 | 2 | 5 | 2.8 | COc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 71735036 | 90873 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 339 | 4 | 2 | 5 | 2.8 | COc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392157 | 90873 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 339 | 4 | 2 | 5 | 2.8 | COc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 71735036 | 90873 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 339 | 4 | 2 | 5 | 2.8 | COc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392157 | 90873 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 339 | 4 | 2 | 5 | 2.8 | COc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 2295463 | 92255 | None | 29 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 279 | 4 | 2 | 5 | 1.5 | O=C(O)COc1ccc(/C=C2\SC(=O)NC2=O)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2425825 | 92255 | None | 29 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 279 | 4 | 2 | 5 | 1.5 | O=C(O)COc1ccc(/C=C2\SC(=O)NC2=O)cc1 | 10.1021/jm4009373 | |||
| 135399235 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.6b01431 | |||
| 2919 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.6b01431 | |||
| 5722 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.6b01431 | |||
| 71735030 | 90868 | None | 0 | Mouse | Binding | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 360 | 3 | 2 | 5 | 3.3 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccccc2n1 | 10.1021/jm400587g | |||
| CHEMBL2392152 | 90868 | None | 0 | Mouse | Binding | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 360 | 3 | 2 | 5 | 3.3 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccccc2n1 | 10.1021/jm400587g | |||
| 71733938 | 90897 | None | 0 | Rat | Binding | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 367 | 6 | 2 | 5 | 3.5 | CCCOc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392181 | 90897 | None | 0 | Rat | Binding | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 367 | 6 | 2 | 5 | 3.5 | CCCOc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 13950958 | 157720 | None | 4 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 362 | 1 | 2 | 4 | 2.7 | O=C(O)c1cc2cc(Br)c(O)c(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4081238 | 157720 | None | 4 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 362 | 1 | 2 | 4 | 2.7 | O=C(O)c1cc2cc(Br)c(O)c(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 11872 | 107519 | None | 41 | Human | Binding | pEC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 198 | 2 | 1 | 5 | 1.5 | Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| CHEMBL3183545 | 107519 | None | 41 | Human | Binding | pEC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 198 | 2 | 1 | 5 | 1.5 | Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| 73294509 | 92252 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 353 | 4 | 2 | 5 | 3.1 | COc1ccc(C(=O)Nc2cc(C)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2425822 | 92252 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 353 | 4 | 2 | 5 | 3.1 | COc1ccc(C(=O)Nc2cc(C)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 71733648 | 90875 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(O)c1cc(=O)c2cc(F)cc(NC(=O)c3cccc(Cl)c3Cl)c2o1 | 10.1021/jm400587g | |||
| CHEMBL2392159 | 90875 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(O)c1cc(=O)c2cc(F)cc(NC(=O)c3cccc(Cl)c3Cl)c2o1 | 10.1021/jm400587g | |||
| 71733842 | 90889 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 412 | 3 | 2 | 5 | 3.4 | N#Cc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392173 | 90889 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 412 | 3 | 2 | 5 | 3.4 | N#Cc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 73294321 | 92251 | None | 0 | Human | Binding | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 435 | 4 | 2 | 5 | 3.7 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1F | 10.1021/jm4009373 | |||
| CHEMBL2425820 | 92251 | None | 0 | Human | Binding | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 435 | 4 | 2 | 5 | 3.7 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1F | 10.1021/jm4009373 | |||
| 73294320 | 92250 | None | 0 | Human | Binding | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 435 | 4 | 2 | 5 | 3.7 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(F)c1 | 10.1021/jm4009373 | |||
| CHEMBL2425819 | 92250 | None | 0 | Human | Binding | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 435 | 4 | 2 | 5 | 3.7 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(F)c1 | 10.1021/jm4009373 | |||
| 71733747 | 90886 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 421 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392170 | 90886 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 421 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)cc1 | 10.1021/jm400587g | |||
| 3325 | 2338 | None | 44 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 10.1021/acs.jmedchem.6b01431 | |||
| 44564 | 2338 | None | 44 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 10.1021/acs.jmedchem.6b01431 | |||
| 9743 | 2338 | None | 44 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL1201266 | 2338 | None | 44 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 10.1021/acs.jmedchem.6b01431 | |||
| DB06794 | 2338 | None | 44 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 311 | 2 | 4 | 5 | 0.3 | N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl | 10.1021/acs.jmedchem.6b01431 | |||
| 2161 | 8735 | None | 73 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 298 | 2 | 2 | 5 | 2.7 | CC(C)c1ccc2oc3nc(N)c(C(=O)O)cc3c(=O)c2c1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL1096 | 8735 | None | 73 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 298 | 2 | 2 | 5 | 2.7 | CC(C)c1ccc2oc3nc(N)c(C(=O)O)cc3c(=O)c2c1 | 10.1021/acs.jmedchem.6b01431 | |||
| 71733848 | 90895 | None | 0 | Rat | Binding | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 451 | 4 | 2 | 5 | 4.2 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(Cl)c1 | 10.1021/jm400587g | |||
| CHEMBL2392179 | 90895 | None | 0 | Rat | Binding | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 451 | 4 | 2 | 5 | 4.2 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(Cl)c1 | 10.1021/jm400587g | |||
| 13681 | 115308 | None | 44 | Human | Binding | pEC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 218 | 2 | 1 | 5 | 1.9 | O=[N+]([O-])c1cc(Cl)c(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| CHEMBL3347428 | 115308 | None | 44 | Human | Binding | pEC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 218 | 2 | 1 | 5 | 1.9 | O=[N+]([O-])c1cc(Cl)c(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| 171348957 | 194383 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 804 | 14 | 3 | 12 | 6.6 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL5285029 | 194383 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 804 | 14 | 3 | 12 | 6.6 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 71734944 | 90864 | None | 0 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 315 | 3 | 2 | 4 | 3.0 | O=C(O)c1cc(=O)c2cccc(NC(=O)C3CCCCC3)c2o1 | 10.1021/jm400587g | |||
| CHEMBL2392148 | 90864 | None | 0 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 315 | 3 | 2 | 4 | 3.0 | O=C(O)c1cc(=O)c2cccc(NC(=O)C3CCCCC3)c2o1 | 10.1021/jm400587g | |||
| 135399235 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.6b01431 | |||
| 2919 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.6b01431 | |||
| 5722 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acs.jmedchem.6b01431 | |||
| 71733846 | 90893 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 447 | 5 | 2 | 6 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1OC | 10.1021/jm400587g | |||
| CHEMBL2392177 | 90893 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 447 | 5 | 2 | 6 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1OC | 10.1021/jm400587g | |||
| 71733846 | 90893 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 447 | 5 | 2 | 6 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1OC | 10.1021/jm400587g | |||
| CHEMBL2392177 | 90893 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 447 | 5 | 2 | 6 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1OC | 10.1021/jm400587g | |||
| 21236027 | 159079 | None | 5 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 313 | 2 | 1 | 5 | 2.2 | O=C(O)c1cc2cc(Br)cc([N+](=O)[O-])c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4096323 | 159079 | None | 5 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 313 | 2 | 1 | 5 | 2.2 | O=C(O)c1cc2cc(Br)cc([N+](=O)[O-])c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 71733652 | 90880 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 343 | 3 | 2 | 4 | 3.4 | O=C(Nc1cc(Cl)cc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm400587g | |||
| CHEMBL2392164 | 90880 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 343 | 3 | 2 | 4 | 3.4 | O=C(Nc1cc(Cl)cc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm400587g | |||
| 13950957 | 157420 | None | 8 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 284 | 1 | 2 | 4 | 2.0 | O=C(O)c1cc2cc(Br)c(O)cc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4077503 | 157420 | None | 8 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 284 | 1 | 2 | 4 | 2.0 | O=C(O)c1cc2cc(Br)c(O)cc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 21982642 | 90859 | None | 0 | Human | Binding | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 235 | 2 | 1 | 5 | 1.4 | O=C(O)c1cc(=O)c2cccc([N+](=O)[O-])c2o1 | 10.1021/jm400587g | |||
| CHEMBL2392142 | 90859 | None | 0 | Human | Binding | pEC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 235 | 2 | 1 | 5 | 1.4 | O=C(O)c1cc(=O)c2cccc([N+](=O)[O-])c2o1 | 10.1021/jm400587g | |||
| 71734946 | 90867 | None | 0 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 359 | 3 | 2 | 4 | 3.9 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccccc2c1 | 10.1021/jm4009373 | |||
| CHEMBL2392151 | 90867 | None | 0 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 359 | 3 | 2 | 4 | 3.9 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccccc2c1 | 10.1021/jm4009373 | |||
| 71734946 | 90867 | None | 0 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 359 | 3 | 2 | 4 | 3.9 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccccc2c1 | 10.1021/jm400587g | |||
| CHEMBL2392151 | 90867 | None | 0 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 359 | 3 | 2 | 4 | 3.9 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccccc2c1 | 10.1021/jm400587g | |||
| 71735036 | 90873 | None | 0 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 339 | 4 | 2 | 5 | 2.8 | COc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392157 | 90873 | None | 0 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 339 | 4 | 2 | 5 | 2.8 | COc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 137646246 | 157827 | None | 4 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 329 | 2 | 2 | 6 | 1.9 | O=C(O)c1cc2cc(Br)c(O)c([N+](=O)[O-])c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4082281 | 157827 | None | 4 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 329 | 2 | 2 | 6 | 1.9 | O=C(O)c1cc2cc(Br)c(O)c([N+](=O)[O-])c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 2882 | 1208 | None | 41 | Mouse | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm400587g | |||
| 741 | 1208 | None | 41 | Mouse | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm400587g | |||
| 7608 | 1208 | None | 41 | Mouse | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm400587g | |||
| CHEMBL428880 | 1208 | None | 41 | Mouse | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm400587g | |||
| DB01003 | 1208 | None | 41 | Mouse | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm400587g | |||
| 171356399 | 194234 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 790 | 13 | 3 | 12 | 6.2 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL5281778 | 194234 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 790 | 13 | 3 | 12 | 6.2 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 71735031 | 90865 | None | 0 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 309 | 3 | 2 | 4 | 2.7 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm4009373 | |||
| CHEMBL2392149 | 90865 | None | 0 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 309 | 3 | 2 | 4 | 2.7 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm4009373 | |||
| 71735031 | 90865 | None | 0 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 309 | 3 | 2 | 4 | 2.7 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm400587g | |||
| CHEMBL2392149 | 90865 | None | 0 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 309 | 3 | 2 | 4 | 2.7 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm400587g | |||
| 4659569 | 22338 | None | 65 | Human | Binding | pEC50 | = | 4.3 | 4.3 | - | 0 | ChEMBL | 273 | 3 | 2 | 5 | 2.5 | Cc1ccc(C(=O)c2cc(O)c(O)c([N+](=O)[O-])c2)cc1 | 10.1039/C2MD20210G | |||
| CHEMBL1324 | 22338 | None | 65 | Human | Binding | pEC50 | = | 4.3 | 4.3 | - | 0 | ChEMBL | 273 | 3 | 2 | 5 | 2.5 | Cc1ccc(C(=O)c2cc(O)c(O)c([N+](=O)[O-])c2)cc1 | 10.1039/C2MD20210G | |||
| 71733845 | 90892 | None | 0 | Mouse | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccccc1C(=O)Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| CHEMBL2392176 | 90892 | None | 0 | Mouse | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccccc1C(=O)Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| 71733940 | 90899 | None | 0 | Mouse | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 418 | 4 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cn1 | 10.1021/jm400587g | |||
| CHEMBL2392183 | 90899 | None | 0 | Mouse | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 418 | 4 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cn1 | 10.1021/jm400587g | |||
| 73294508 | 1140 | None | 0 | Human | Binding | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 453 | 4 | 2 | 5 | 3.8 | COc1cc(F)c(c(c1)F)C(=O)Nc1cc(Br)cc2c1oc(cc2=O)C(=O)O | 10.1021/jm4009373 | |||
| 9742 | 1140 | None | 0 | Human | Binding | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 453 | 4 | 2 | 5 | 3.8 | COc1cc(F)c(c(c1)F)C(=O)Nc1cc(Br)cc2c1oc(cc2=O)C(=O)O | 10.1021/jm4009373 | |||
| CHEMBL2425821 | 1140 | None | 0 | Human | Binding | pEC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 453 | 4 | 2 | 5 | 3.8 | COc1cc(F)c(c(c1)F)C(=O)Nc1cc(Br)cc2c1oc(cc2=O)C(=O)O | 10.1021/jm4009373 | |||
| 137662152 | 159485 | None | 11 | Human | Binding | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 353 | 2 | 2 | 8 | 1.3 | O=c1oc2c([N+](=O)[O-])c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4100677 | 159485 | None | 11 | Human | Binding | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 353 | 2 | 2 | 8 | 1.3 | O=c1oc2c([N+](=O)[O-])c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 137662152 | 159485 | None | 11 | Human | Binding | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 353 | 2 | 2 | 8 | 1.3 | O=c1oc2c([N+](=O)[O-])c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4100677 | 159485 | None | 11 | Human | Binding | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 353 | 2 | 2 | 8 | 1.3 | O=c1oc2c([N+](=O)[O-])c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 2920 | 2997 | None | 64 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm400587g | |||
| 54742459 | 2997 | None | 64 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm400587g | |||
| 8546 | 2997 | None | 64 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm400587g | |||
| CHEMBL177880 | 2997 | None | 64 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm400587g | |||
| 2920 | 2997 | None | 64 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acs.jmedchem.6b01431 | |||
| 54742459 | 2997 | None | 64 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acs.jmedchem.6b01431 | |||
| 8546 | 2997 | None | 64 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL177880 | 2997 | None | 64 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acs.jmedchem.6b01431 | |||
| 71735036 | 90873 | None | 0 | Mouse | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 339 | 4 | 2 | 5 | 2.8 | COc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392157 | 90873 | None | 0 | Mouse | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 339 | 4 | 2 | 5 | 2.8 | COc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 137646246 | 157827 | None | 4 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 329 | 2 | 2 | 6 | 1.9 | O=C(O)c1cc2cc(Br)c(O)c([N+](=O)[O-])c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4082281 | 157827 | None | 4 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 329 | 2 | 2 | 6 | 1.9 | O=C(O)c1cc2cc(Br)c(O)c([N+](=O)[O-])c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 137646246 | 157827 | None | 4 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 329 | 2 | 2 | 6 | 1.9 | O=C(O)c1cc2cc(Br)c(O)c([N+](=O)[O-])c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4082281 | 157827 | None | 4 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 329 | 2 | 2 | 6 | 1.9 | O=C(O)c1cc2cc(Br)c(O)c([N+](=O)[O-])c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 2882 | 1208 | None | 41 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acs.jmedchem.6b01431 | |||
| 741 | 1208 | None | 41 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acs.jmedchem.6b01431 | |||
| 7608 | 1208 | None | 41 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL428880 | 1208 | None | 41 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acs.jmedchem.6b01431 | |||
| DB01003 | 1208 | None | 41 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acs.jmedchem.6b01431 | |||
| 2882 | 1208 | None | 41 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 741 | 1208 | None | 41 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 7608 | 1208 | None | 41 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL428880 | 1208 | None | 41 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| DB01003 | 1208 | None | 41 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 2882 | 1208 | None | 41 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm4009373 | |||
| 741 | 1208 | None | 41 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm4009373 | |||
| 7608 | 1208 | None | 41 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm4009373 | |||
| CHEMBL428880 | 1208 | None | 41 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm4009373 | |||
| DB01003 | 1208 | None | 41 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm4009373 | |||
| 9492 | 5471 | None | 25 | Human | Binding | pEC50 | = | 4.3 | 4.3 | - | 0 | ChEMBL | 184 | 2 | 1 | 5 | 1.2 | O=[N+]([O-])c1ccc([N+](=O)[O-])c(O)c1 | 10.1039/C2MD20210G | |||
| CHEMBL107513 | 5471 | None | 25 | Human | Binding | pEC50 | = | 4.3 | 4.3 | - | 0 | ChEMBL | 184 | 2 | 1 | 5 | 1.2 | O=[N+]([O-])c1ccc([N+](=O)[O-])c(O)c1 | 10.1039/C2MD20210G | |||
| 11872 | 107519 | None | 41 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 198 | 2 | 1 | 5 | 1.5 | Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| CHEMBL3183545 | 107519 | None | 41 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 198 | 2 | 1 | 5 | 1.5 | Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| 4921319 | 107517 | None | 34 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 199 | 2 | 2 | 6 | 0.8 | Nc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1O | 10.1039/C2MD20210G | |||
| CHEMBL3183248 | 107517 | None | 34 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 199 | 2 | 2 | 6 | 0.8 | Nc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1O | 10.1039/C2MD20210G | |||
| 71735032 | 90869 | None | 0 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 323 | 3 | 2 | 4 | 3.1 | Cc1cccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm400587g | |||
| CHEMBL2392153 | 90869 | None | 0 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 323 | 3 | 2 | 4 | 3.1 | Cc1cccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm400587g | |||
| 3495594 | 17196 | None | 28 | Human | Binding | pEC50 | = | 4.3 | 4.3 | - | 0 | ChEMBL | 277 | 3 | 2 | 5 | 2.4 | O=C(c1cc(O)c(O)c([N+](=O)[O-])c1)c1ccccc1F | 10.1039/C2MD20210G | |||
| CHEMBL1256291 | 17196 | None | 28 | Human | Binding | pEC50 | = | 4.3 | 4.3 | - | 0 | ChEMBL | 277 | 3 | 2 | 5 | 2.4 | O=C(c1cc(O)c(O)c([N+](=O)[O-])c1)c1ccccc1F | 10.1039/C2MD20210G | |||
| 13681 | 115308 | None | 44 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 218 | 2 | 1 | 5 | 1.9 | O=[N+]([O-])c1cc(Cl)c(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| CHEMBL3347428 | 115308 | None | 44 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 218 | 2 | 1 | 5 | 1.9 | O=[N+]([O-])c1cc(Cl)c(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| 1231538 | 27526 | None | 29 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 523 | 6 | 1 | 6 | 6.0 | O=C(Nc1ccc2nc(SCc3ccc(Cl)cc3)sc2c1)c1ccccc1C(=O)N1CCOCC1 | 10.1016/j.bmcl.2016.12.012 | |||
| CHEMBL1368962 | 27526 | None | 29 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 523 | 6 | 1 | 6 | 6.0 | O=C(Nc1ccc2nc(SCc3ccc(Cl)cc3)sc2c1)c1ccccc1C(=O)N1CCOCC1 | 10.1016/j.bmcl.2016.12.012 | |||
| 5281081 | 210115 | None | 57 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 305 | 5 | 2 | 6 | 1.8 | CCN(CC)C(=O)/C(C#N)=C/c1cc(O)c(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| CHEMBL953 | 210115 | None | 57 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 305 | 5 | 2 | 6 | 1.8 | CCN(CC)C(=O)/C(C#N)=C/c1cc(O)c(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| 137632988 | 156459 | None | 4 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 294 | 1 | 0 | 5 | 2.3 | N#Cc1cc2cc(Br)cc([N+](=O)[O-])c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4066109 | 156459 | None | 4 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 294 | 1 | 0 | 5 | 2.3 | N#Cc1cc2cc(Br)cc([N+](=O)[O-])c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 171345773 | 194513 | None | 0 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 806 | 14 | 3 | 13 | 5.4 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCOCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL5288015 | 194513 | None | 0 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 806 | 14 | 3 | 13 | 5.4 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCOCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 6191 | 115306 | None | 21 | Human | Binding | pEC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 184 | 2 | 1 | 5 | 1.2 | O=[N+]([O-])c1cccc(O)c1[N+](=O)[O-] | 10.1039/C2MD20210G | |||
| CHEMBL3347393 | 115306 | None | 21 | Human | Binding | pEC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 184 | 2 | 1 | 5 | 1.2 | O=[N+]([O-])c1cccc(O)c1[N+](=O)[O-] | 10.1039/C2MD20210G | |||
| 71733847 | 90894 | None | 0 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 431 | 3 | 2 | 6 | 3.2 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc2c(c1)OCO2 | 10.1021/jm400587g | |||
| CHEMBL2392178 | 90894 | None | 0 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 431 | 3 | 2 | 6 | 3.2 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc2c(c1)OCO2 | 10.1021/jm400587g | |||
| 3254949 | 115310 | None | 3 | Human | Binding | pEC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 460 | 6 | 2 | 10 | 3.9 | O=[N+]([O-])c1cc(C(=C(Cl)Cl)c2cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c2)cc([N+](=O)[O-])c1O | 10.1039/C2MD20210G | |||
| CHEMBL3347474 | 115310 | None | 3 | Human | Binding | pEC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 460 | 6 | 2 | 10 | 3.9 | O=[N+]([O-])c1cc(C(=C(Cl)Cl)c2cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c2)cc([N+](=O)[O-])c1O | 10.1039/C2MD20210G | |||
| 73294319 | 92254 | None | 0 | Human | Binding | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 391 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)c(F)c1 | 10.1021/jm4009373 | |||
| CHEMBL2425824 | 92254 | None | 0 | Human | Binding | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 391 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)c(F)c1 | 10.1021/jm4009373 | |||
| 135399235 | 4134 | None | 41 | Rat | Binding | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm400587g | |||
| 2919 | 4134 | None | 41 | Rat | Binding | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm400587g | |||
| 5722 | 4134 | None | 41 | Rat | Binding | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm400587g | |||
| CHEMBL28079 | 4134 | None | 41 | Rat | Binding | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm400587g | |||
| 118985385 | 1701 | None | 63 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | |||
| 1258 | 1701 | None | 63 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | |||
| 3440 | 1701 | None | 63 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | |||
| 4839 | 1701 | None | 63 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | |||
| CHEMBL35 | 1701 | None | 63 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | |||
| DB00695 | 1701 | None | 63 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | |||
| 71733846 | 90893 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 447 | 5 | 2 | 6 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1OC | 10.1021/jm400587g | |||
| CHEMBL2392177 | 90893 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 447 | 5 | 2 | 6 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1OC | 10.1021/jm400587g | |||
| 71733844 | 90891 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 431 | 5 | 2 | 5 | 3.9 | CCOc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392175 | 90891 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 431 | 5 | 2 | 5 | 3.9 | CCOc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm400587g | |||
| 71733846 | 90893 | None | 0 | Mouse | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 447 | 5 | 2 | 6 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1OC | 10.1021/jm400587g | |||
| CHEMBL2392177 | 90893 | None | 0 | Mouse | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 447 | 5 | 2 | 6 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1OC | 10.1021/jm400587g | |||
| 5281081 | 210115 | None | 57 | Human | Binding | pEC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 305 | 5 | 2 | 6 | 1.8 | CCN(CC)C(=O)/C(C#N)=C/c1cc(O)c(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| CHEMBL953 | 210115 | None | 57 | Human | Binding | pEC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 305 | 5 | 2 | 6 | 1.8 | CCN(CC)C(=O)/C(C#N)=C/c1cc(O)c(O)c([N+](=O)[O-])c1 | 10.1039/C2MD20210G | |||
| 137653726 | 158768 | None | 4 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 386 | 1 | 2 | 6 | 2.2 | O=c1oc2c(Br)c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4092954 | 158768 | None | 4 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 386 | 1 | 2 | 6 | 2.2 | O=c1oc2c(Br)c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 2918 | 2204 | None | 75 | Rat | Binding | pEC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 10.1021/jm400587g | |||
| 3845 | 2204 | None | 75 | Rat | Binding | pEC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 10.1021/jm400587g | |||
| CHEMBL299155 | 2204 | None | 75 | Rat | Binding | pEC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 10.1021/jm400587g | |||
| DB11937 | 2204 | None | 75 | Rat | Binding | pEC50 | = | 4.2 | 4.2 | - | 0 | ChEMBL | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 10.1021/jm400587g | |||
| 71734943 | 90863 | None | 0 | Rat | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 305 | 4 | 2 | 6 | 1.0 | COC(=O)CC(=O)Nc1cccc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| CHEMBL2392147 | 90863 | None | 0 | Rat | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 305 | 4 | 2 | 6 | 1.0 | COC(=O)CC(=O)Nc1cccc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| 20486870 | 61117 | None | 4 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 214 | 1 | 1 | 5 | 1.0 | O=c1oc2ccccc2cc1-c1nn[nH]n1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL1765162 | 61117 | None | 4 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 214 | 1 | 1 | 5 | 1.0 | O=c1oc2ccccc2cc1-c1nn[nH]n1 | 10.1021/acs.jmedchem.6b01431 | |||
| 71733647 | 90874 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 387 | 3 | 2 | 4 | 3.5 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc(Br)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392158 | 90874 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 387 | 3 | 2 | 4 | 3.5 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc(Br)cc1 | 10.1021/jm400587g | |||
| 137653726 | 158768 | None | 4 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 386 | 1 | 2 | 6 | 2.2 | O=c1oc2c(Br)c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4092954 | 158768 | None | 4 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 386 | 1 | 2 | 6 | 2.2 | O=c1oc2c(Br)c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 10800 | 163504 | None | 34 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 198 | 2 | 1 | 5 | 1.5 | Cc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1O | 10.1039/C2MD20210G | |||
| CHEMBL419564 | 163504 | None | 34 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 198 | 2 | 1 | 5 | 1.5 | Cc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1O | 10.1039/C2MD20210G | |||
| 71735033 | 90870 | None | 0 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 354 | 4 | 2 | 6 | 2.7 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1cccc([N+](=O)[O-])c1 | 10.1021/jm400587g | |||
| CHEMBL2392154 | 90870 | None | 0 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 354 | 4 | 2 | 6 | 2.7 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1cccc([N+](=O)[O-])c1 | 10.1021/jm400587g | |||
| 71733746 | 90885 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 401 | 3 | 2 | 4 | 3.8 | Cc1cccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm400587g | |||
| CHEMBL2392169 | 90885 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 401 | 3 | 2 | 4 | 3.8 | Cc1cccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm400587g | |||
| 137632988 | 156459 | None | 4 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 294 | 1 | 0 | 5 | 2.3 | N#Cc1cc2cc(Br)cc([N+](=O)[O-])c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4066109 | 156459 | None | 4 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 294 | 1 | 0 | 5 | 2.3 | N#Cc1cc2cc(Br)cc([N+](=O)[O-])c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 2882 | 1208 | None | 41 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 741 | 1208 | None | 41 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 7608 | 1208 | None | 41 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL428880 | 1208 | None | 41 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| DB01003 | 1208 | None | 41 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 2882 | 1208 | None | 41 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acs.jmedchem.6b01431 | |||
| 741 | 1208 | None | 41 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acs.jmedchem.6b01431 | |||
| 7608 | 1208 | None | 41 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL428880 | 1208 | None | 41 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acs.jmedchem.6b01431 | |||
| DB01003 | 1208 | None | 41 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acs.jmedchem.6b01431 | |||
| 137632781 | 156378 | None | 4 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 370 | 1 | 1 | 5 | 2.5 | O=c1oc2c(Br)cc(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4065291 | 156378 | None | 4 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 370 | 1 | 1 | 5 | 2.5 | O=c1oc2c(Br)cc(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 137641148 | 157139 | None | 4 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 308 | 1 | 2 | 6 | 1.4 | O=c1oc2cc(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4073902 | 157139 | None | 4 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 308 | 1 | 2 | 6 | 1.4 | O=c1oc2cc(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 4659569 | 22338 | None | 65 | Human | Binding | pEC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 273 | 3 | 2 | 5 | 2.5 | Cc1ccc(C(=O)c2cc(O)c(O)c([N+](=O)[O-])c2)cc1 | 10.1039/C2MD20210G | |||
| CHEMBL1324 | 22338 | None | 65 | Human | Binding | pEC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 273 | 3 | 2 | 5 | 2.5 | Cc1ccc(C(=O)c2cc(O)c(O)c([N+](=O)[O-])c2)cc1 | 10.1039/C2MD20210G | |||
| 11312 | 111581 | None | 28 | Human | Binding | pEC50 | = | 4.1 | 4.1 | - | 0 | ChEMBL | 184 | 2 | 1 | 5 | 1.2 | O=[N+]([O-])c1cccc([N+](=O)[O-])c1O | 10.1039/C2MD20210G | |||
| CHEMBL3278560 | 111581 | None | 28 | Human | Binding | pEC50 | = | 4.1 | 4.1 | - | 0 | ChEMBL | 184 | 2 | 1 | 5 | 1.2 | O=[N+]([O-])c1cccc([N+](=O)[O-])c1O | 10.1039/C2MD20210G | |||
| 171351254 | 194562 | None | 0 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 776 | 12 | 3 | 12 | 5.8 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL5289040 | 194562 | None | 0 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 776 | 12 | 3 | 12 | 5.8 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 135468531 | 90858 | None | 19 | Rat | Binding | pEC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 342 | 3 | 2 | 4 | 3.4 | O=C1N/C(=N/c2ccccc2F)S/C1=C\c1ccc(C(=O)O)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392141 | 90858 | None | 19 | Rat | Binding | pEC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 342 | 3 | 2 | 4 | 3.4 | O=C1N/C(=N/c2ccccc2F)S/C1=C\c1ccc(C(=O)O)cc1 | 10.1021/jm400587g | |||
| 71733647 | 90874 | None | 0 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 387 | 3 | 2 | 4 | 3.5 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc(Br)cc1 | 10.1021/jm400587g | |||
| CHEMBL2392158 | 90874 | None | 0 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 387 | 3 | 2 | 4 | 3.5 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc(Br)cc1 | 10.1021/jm400587g | |||
| 10800 | 163504 | None | 34 | Human | Binding | pEC50 | = | 4.1 | 4.1 | - | 0 | ChEMBL | 198 | 2 | 1 | 5 | 1.5 | Cc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1O | 10.1039/C2MD20210G | |||
| CHEMBL419564 | 163504 | None | 34 | Human | Binding | pEC50 | = | 4.1 | 4.1 | - | 0 | ChEMBL | 198 | 2 | 1 | 5 | 1.5 | Cc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1O | 10.1039/C2MD20210G | |||
| 5464105 | 57849 | None | 47 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 265 | 4 | 2 | 6 | 1.6 | CC(=O)C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)C(C)=O | 10.1039/C2MD20210G | |||
| CHEMBL167055 | 57849 | None | 47 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 265 | 4 | 2 | 6 | 1.6 | CC(=O)C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)C(C)=O | 10.1039/C2MD20210G | |||
| 137654727 | 158837 | None | 4 | Human | Binding | pEC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 357 | 1 | 0 | 4 | 3.2 | COc1c(Br)cc2cc(C#N)c(=O)oc2c1Br | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4093683 | 158837 | None | 4 | Human | Binding | pEC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 357 | 1 | 0 | 4 | 3.2 | COc1c(Br)cc2cc(C#N)c(=O)oc2c1Br | 10.1021/acs.jmedchem.6b01431 | |||
| 71733746 | 90885 | None | 0 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 401 | 3 | 2 | 4 | 3.8 | Cc1cccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm400587g | |||
| CHEMBL2392169 | 90885 | None | 0 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 401 | 3 | 2 | 4 | 3.8 | Cc1cccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm400587g | |||
| 5066064 | 157464 | None | 5 | Human | Binding | pEC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 239 | 0 | 0 | 3 | 3.0 | N#Cc1cc2cc(Cl)cc(Cl)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4078055 | 157464 | None | 5 | Human | Binding | pEC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 239 | 0 | 0 | 3 | 3.0 | N#Cc1cc2cc(Cl)cc(Cl)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 3495594 | 17196 | None | 28 | Human | Binding | pEC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 277 | 3 | 2 | 5 | 2.4 | O=C(c1cc(O)c(O)c([N+](=O)[O-])c1)c1ccccc1F | 10.1039/C2MD20210G | |||
| CHEMBL1256291 | 17196 | None | 28 | Human | Binding | pEC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 277 | 3 | 2 | 5 | 2.4 | O=C(c1cc(O)c(O)c([N+](=O)[O-])c1)c1ccccc1F | 10.1039/C2MD20210G | |||
| 71733648 | 90875 | None | 0 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(O)c1cc(=O)c2cc(F)cc(NC(=O)c3cccc(Cl)c3Cl)c2o1 | 10.1021/jm400587g | |||
| CHEMBL2392159 | 90875 | None | 0 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(O)c1cc(=O)c2cc(F)cc(NC(=O)c3cccc(Cl)c3Cl)c2o1 | 10.1021/jm400587g | |||
| 137658472 | 159894 | None | 4 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 376 | 2 | 1 | 4 | 3.0 | COc1c(Br)cc2cc(C(=O)O)c(=O)oc2c1Br | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4105535 | 159894 | None | 4 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 376 | 2 | 1 | 4 | 3.0 | COc1c(Br)cc2cc(C(=O)O)c(=O)oc2c1Br | 10.1021/acs.jmedchem.6b01431 | |||
| 137658472 | 159894 | None | 4 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 376 | 2 | 1 | 4 | 3.0 | COc1c(Br)cc2cc(C(=O)O)c(=O)oc2c1Br | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4105535 | 159894 | None | 4 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 376 | 2 | 1 | 4 | 3.0 | COc1c(Br)cc2cc(C(=O)O)c(=O)oc2c1Br | 10.1021/acs.jmedchem.6b01431 | |||
| 71734945 | 90866 | None | 0 | Human | Binding | pEC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 323 | 4 | 2 | 4 | 2.7 | O=C(Cc1ccccc1)Nc1cccc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| CHEMBL2392150 | 90866 | None | 0 | Human | Binding | pEC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 323 | 4 | 2 | 4 | 2.7 | O=C(Cc1ccccc1)Nc1cccc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm400587g | |||
| 10752 | 208275 | None | 69 | Human | Binding | pEC50 | = | 4.0 | 4.0 | - | 0 | ChEMBL | 190 | 1 | 1 | 3 | 1.5 | O=C(O)c1cc2ccccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL83294 | 208275 | None | 69 | Human | Binding | pEC50 | = | 4.0 | 4.0 | - | 0 | ChEMBL | 190 | 1 | 1 | 3 | 1.5 | O=C(O)c1cc2ccccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 137643561 | 158144 | None | 4 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 265 | 0 | 1 | 4 | 2.1 | N#Cc1cc2cc(Br)c(O)cc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4085935 | 158144 | None | 4 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 265 | 0 | 1 | 4 | 2.1 | N#Cc1cc2cc(Br)c(O)cc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 137632781 | 156378 | None | 4 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 370 | 1 | 1 | 5 | 2.5 | O=c1oc2c(Br)cc(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4065291 | 156378 | None | 4 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 370 | 1 | 1 | 5 | 2.5 | O=c1oc2c(Br)cc(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 137632781 | 156378 | None | 4 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 370 | 1 | 1 | 5 | 2.5 | O=c1oc2c(Br)cc(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4065291 | 156378 | None | 4 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 370 | 1 | 1 | 5 | 2.5 | O=c1oc2c(Br)cc(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 54676038 | 38734 | None | 51 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 336 | 2 | 2 | 6 | 2.9 | O=c1oc2ccccc2c(O)c1Cc1c(O)c2ccccc2oc1=O | 10.1021/jm4009373 | |||
| CHEMBL1466 | 38734 | None | 51 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 336 | 2 | 2 | 6 | 2.9 | O=c1oc2ccccc2c(O)c1Cc1c(O)c2ccccc2oc1=O | 10.1021/jm4009373 | |||
| 135399235 | 4134 | None | 41 | Mouse | Binding | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm400587g | |||
| 2919 | 4134 | None | 41 | Mouse | Binding | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm400587g | |||
| 5722 | 4134 | None | 41 | Mouse | Binding | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm400587g | |||
| CHEMBL28079 | 4134 | None | 41 | Mouse | Binding | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm400587g | |||
| 2882 | 1208 | None | 41 | Rat | Binding | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm400587g | |||
| 741 | 1208 | None | 41 | Rat | Binding | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm400587g | |||
| 7608 | 1208 | None | 41 | Rat | Binding | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm400587g | |||
| CHEMBL428880 | 1208 | None | 41 | Rat | Binding | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm400587g | |||
| DB01003 | 1208 | None | 41 | Rat | Binding | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm400587g | |||
| 71733940 | 90899 | None | 0 | Rat | Binding | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 418 | 4 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cn1 | 10.1021/jm400587g | |||
| CHEMBL2392183 | 90899 | None | 0 | Rat | Binding | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 418 | 4 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cn1 | 10.1021/jm400587g | |||
| 5281855 | 205301 | None | 65 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 302 | 0 | 4 | 8 | 1.3 | O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23 | 10.1021/ml2003058 | |||
| CHEMBL6246 | 205301 | None | 65 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 302 | 0 | 4 | 8 | 1.3 | O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23 | 10.1021/ml2003058 | |||
| 10752 | 208275 | None | 69 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 190 | 1 | 1 | 3 | 1.5 | O=C(O)c1cc2ccccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL83294 | 208275 | None | 69 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 190 | 1 | 1 | 3 | 1.5 | O=C(O)c1cc2ccccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 171351254 | 194562 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 776 | 12 | 3 | 12 | 5.8 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL5289040 | 194562 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 776 | 12 | 3 | 12 | 5.8 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 2745687 | 933 | None | 27 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 10.1021/jm4009373 | |||
| 9741 | 933 | None | 27 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 10.1021/jm4009373 | |||
| CHEMBL1708510 | 933 | None | 27 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 10.1021/jm4009373 | |||
| 725495 | 65557 | None | 43 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 346 | 1 | 1 | 3 | 3.0 | O=C(O)c1cc2cc(Br)cc(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL1830823 | 65557 | None | 43 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 346 | 1 | 1 | 3 | 3.0 | O=C(O)c1cc2cc(Br)cc(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 16103462 | 68091 | None | 17 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 276 | 1 | 1 | 3 | 3.7 | Cc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/ml2003058 | |||
| CHEMBL1914588 | 68091 | None | 17 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 276 | 1 | 1 | 3 | 3.7 | Cc1c(C(=O)O)sc2c(Br)csc12 | 10.1021/ml2003058 | |||
| 153273978 | 198382 | None | 6 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 248 | 1 | 4 | 5 | 1.0 | O=C(O)c1cc(O)c(=O)c2c(O)c(O)ccc2c1 | 10.1021/ml2003058 | |||
| 5098885 | 198382 | None | 6 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 248 | 1 | 4 | 5 | 1.0 | O=C(O)c1cc(O)c(=O)c2c(O)c(O)ccc2c1 | 10.1021/ml2003058 | |||
| CHEMBL559337 | 198382 | None | 6 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 248 | 1 | 4 | 5 | 1.0 | O=C(O)c1cc(O)c(=O)c2c(O)c(O)ccc2c1 | 10.1021/ml2003058 | |||
| 694463 | 87514 | None | 63 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 268 | 1 | 1 | 3 | 2.3 | O=C(O)c1cc2cc(Br)ccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL2333943 | 87514 | None | 63 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 268 | 1 | 1 | 3 | 2.3 | O=C(O)c1cc2cc(Br)ccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 135399235 | 4134 | None | 41 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml2003058 | |||
| 2919 | 4134 | None | 41 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml2003058 | |||
| 5722 | 4134 | None | 41 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml2003058 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/ml2003058 | |||
| 4488 | 205479 | None | 66 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | 10.1021/ml2003058 | |||
| CHEMBL63323 | 205479 | None | 66 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | 10.1021/ml2003058 | |||
| 137652009 | 157606 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 320 | 3 | 2 | 10 | 0.5 | O=c1oc2c([N+](=O)[O-])c(O)c([N+](=O)[O-])cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4079816 | 157606 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 320 | 3 | 2 | 10 | 0.5 | O=c1oc2c([N+](=O)[O-])c(O)c([N+](=O)[O-])cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 137635873 | 155962 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 539 | 6 | 1 | 6 | 5.0 | O=C(Nc1ccc2nc([S+]([O-])Cc3ccc(Cl)cc3)sc2c1)c1ccccc1C(=O)N1CCOCC1 | 10.1016/j.bmcl.2016.12.012 | |||
| CHEMBL4060393 | 155962 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 539 | 6 | 1 | 6 | 5.0 | O=C(Nc1ccc2nc([S+]([O-])Cc3ccc(Cl)cc3)sc2c1)c1ccccc1C(=O)N1CCOCC1 | 10.1016/j.bmcl.2016.12.012 | |||
| 271643 | 32788 | None | 45 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 224 | 1 | 1 | 3 | 2.1 | O=C(O)c1cc2cc(Cl)ccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL1414071 | 32788 | None | 45 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 224 | 1 | 1 | 3 | 2.1 | O=C(O)c1cc2cc(Cl)ccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 137636652 | 156140 | None | 4 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 322 | 2 | 1 | 6 | 1.7 | COc1cc2oc(=O)c(-c3nnn[nH]3)cc2cc1Br | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4062531 | 156140 | None | 4 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 322 | 2 | 1 | 6 | 1.7 | COc1cc2oc(=O)c(-c3nnn[nH]3)cc2cc1Br | 10.1021/acs.jmedchem.6b01431 | |||
| 137655259 | 159060 | None | 4 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 327 | 0 | 0 | 3 | 3.2 | N#Cc1cc2cc(Br)cc(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4096105 | 159060 | None | 4 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 327 | 0 | 0 | 3 | 3.2 | N#Cc1cc2cc(Br)cc(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 5280343 | 188382 | None | 69 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 32 | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/ml2003058 | |||
| CHEMBL1520590 | 188382 | None | 69 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 32 | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/ml2003058 | |||
| CHEMBL50 | 188382 | None | 69 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 32 | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/ml2003058 | |||
| 411 | 2593 | None | 63 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 3 | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | Oc1ccc(c(c1)O)c1oc2cc(O)cc(c2c(=O)c1O)O | 10.1021/ml2003058 | |||
| 5281670 | 2593 | None | 63 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 3 | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | Oc1ccc(c(c1)O)c1oc2cc(O)cc(c2c(=O)c1O)O | 10.1021/ml2003058 | |||
| CHEMBL28626 | 2593 | None | 63 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 3 | ChEMBL | 302 | 1 | 5 | 7 | 2.0 | Oc1ccc(c(c1)O)c1oc2cc(O)cc(c2c(=O)c1O)O | 10.1021/ml2003058 | |||
| 137647862 | 157745 | None | 4 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 324 | 2 | 0 | 6 | 2.3 | COc1c(Br)cc2cc(C#N)c(=O)oc2c1[N+](=O)[O-] | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4081445 | 157745 | None | 4 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 324 | 2 | 0 | 6 | 2.3 | COc1c(Br)cc2cc(C#N)c(=O)oc2c1[N+](=O)[O-] | 10.1021/acs.jmedchem.6b01431 | |||
| 137647638 | 157730 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 537 | 6 | 1 | 6 | 6.5 | CC(Sc1nc2ccc(NC(=O)c3ccccc3C(=O)N3CCOCC3)cc2s1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.12.012 | |||
| CHEMBL4081331 | 157730 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 537 | 6 | 1 | 6 | 6.5 | CC(Sc1nc2ccc(NC(=O)c3ccccc3C(=O)N3CCOCC3)cc2s1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2016.12.012 | |||
| 5215 | 2386 | None | 74 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 286 | 1 | 4 | 6 | 2.3 | Oc1cc(O)c2c(c1)oc(cc2=O)c1ccc(c(c1)O)O | 10.1021/ml2003058 | |||
| 5280445 | 2386 | None | 74 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 286 | 1 | 4 | 6 | 2.3 | Oc1cc(O)c2c(c1)oc(cc2=O)c1ccc(c(c1)O)O | 10.1021/ml2003058 | |||
| CHEMBL151 | 2386 | None | 74 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 286 | 1 | 4 | 6 | 2.3 | Oc1cc(O)c2c(c1)oc(cc2=O)c1ccc(c(c1)O)O | 10.1021/ml2003058 | |||
| 2745687 | 933 | None | 27 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 9741 | 933 | None | 27 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL1708510 | 933 | None | 27 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 2745687 | 933 | None | 27 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 10.1021/jm4009373 | |||
| 9741 | 933 | None | 27 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 10.1021/jm4009373 | |||
| CHEMBL1708510 | 933 | None | 27 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 10.1021/jm4009373 | |||
| 5281672 | 56570 | None | 72 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 318 | 1 | 6 | 8 | 1.7 | O=c1c(O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/ml2003058 | |||
| CHEMBL164 | 56570 | None | 72 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 318 | 1 | 6 | 8 | 1.7 | O=c1c(O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)cc(O)c12 | 10.1021/ml2003058 | |||
| 782693 | 158333 | None | 19 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 205 | 0 | 0 | 3 | 2.3 | N#Cc1cc2cc(Cl)ccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4088382 | 158333 | None | 19 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 205 | 0 | 0 | 3 | 2.3 | N#Cc1cc2cc(Cl)ccc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 137653726 | 158768 | None | 4 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 386 | 1 | 2 | 6 | 2.2 | O=c1oc2c(Br)c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4092954 | 158768 | None | 4 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 386 | 1 | 2 | 6 | 2.2 | O=c1oc2c(Br)c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 657910 | 53468 | None | 35 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 258 | 1 | 1 | 3 | 2.8 | O=C(O)c1cc2cc(Cl)cc(Cl)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL1600989 | 53468 | None | 35 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 258 | 1 | 1 | 3 | 2.8 | O=C(O)c1cc2cc(Cl)cc(Cl)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 2286812 | 29474 | None | 32 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 482 | 8 | 3 | 6 | 4.7 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)c(O)c2)C1=O)=C\c1ccccc1 | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL1384502 | 29474 | None | 32 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 482 | 8 | 3 | 6 | 4.7 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)c(O)c2)C1=O)=C\c1ccccc1 | 10.1021/acsmedchemlett.2c00461 | |||
| 2286812 | 29474 | None | 32 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 482 | 8 | 3 | 6 | 4.7 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)c(O)c2)C1=O)=C\c1ccccc1 | 10.1021/jm4009373 | |||
| CHEMBL1384502 | 29474 | None | 32 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 482 | 8 | 3 | 6 | 4.7 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)c(O)c2)C1=O)=C\c1ccccc1 | 10.1021/jm4009373 | |||
| 137646097 | 157992 | None | 4 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 367 | 3 | 1 | 8 | 1.7 | COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1[N+](=O)[O-] | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4084237 | 157992 | None | 4 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 367 | 3 | 1 | 8 | 1.7 | COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1[N+](=O)[O-] | 10.1021/acs.jmedchem.6b01431 | |||
| 5281605 | 208190 | None | 72 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 270 | 1 | 3 | 5 | 2.6 | O=c1cc(-c2ccccc2)oc2cc(O)c(O)c(O)c12 | 10.1021/ml2003058 | |||
| CHEMBL8260 | 208190 | None | 72 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 270 | 1 | 3 | 5 | 2.6 | O=c1cc(-c2ccccc2)oc2cc(O)c(O)c(O)c12 | 10.1021/ml2003058 | |||
| 137658268 | 159756 | None | 4 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 343 | 0 | 1 | 4 | 2.9 | N#Cc1cc2cc(Br)c(O)c(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4103860 | 159756 | None | 4 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 343 | 0 | 1 | 4 | 2.9 | N#Cc1cc2cc(Br)c(O)c(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 135403802 | 26539 | None | 39 | Human | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 300 | 0 | 4 | 6 | 1.3 | O=C1C=C2CC3(O)COc4c(ccc(O)c4O)C3=C2C=C1O | 10.1021/ml2003058 | |||
| CHEMBL1360563 | 26539 | None | 39 | Human | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 300 | 0 | 4 | 6 | 1.3 | O=C1C=C2CC3(O)COc4c(ccc(O)c4O)C3=C2C=C1O | 10.1021/ml2003058 | |||
| 5328791 | 207442 | None | 48 | Human | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 189 | 2 | 2 | 3 | 1.4 | N#C/C(=C\c1ccc(O)cc1)C(=O)O | 10.1021/ml2003058 | |||
| CHEMBL76602 | 207442 | None | 48 | Human | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 189 | 2 | 2 | 3 | 1.4 | N#C/C(=C\c1ccc(O)cc1)C(=O)O | 10.1021/ml2003058 | |||
| 137646246 | 157827 | None | 4 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 329 | 2 | 2 | 6 | 1.9 | O=C(O)c1cc2cc(Br)c(O)c([N+](=O)[O-])c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4082281 | 157827 | None | 4 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 329 | 2 | 2 | 6 | 1.9 | O=C(O)c1cc2cc(Br)c(O)c([N+](=O)[O-])c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 137648473 | 158084 | None | 4 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 337 | 2 | 1 | 7 | 1.6 | O=c1oc2c([N+](=O)[O-])cc(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4085211 | 158084 | None | 4 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 337 | 2 | 1 | 7 | 1.6 | O=c1oc2c([N+](=O)[O-])cc(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 21236027 | 159079 | None | 5 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 313 | 2 | 1 | 5 | 2.2 | O=C(O)c1cc2cc(Br)cc([N+](=O)[O-])c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4096323 | 159079 | None | 5 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 313 | 2 | 1 | 5 | 2.2 | O=C(O)c1cc2cc(Br)cc([N+](=O)[O-])c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 13950957 | 157420 | None | 8 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 284 | 1 | 2 | 4 | 2.0 | O=C(O)c1cc2cc(Br)c(O)cc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4077503 | 157420 | None | 8 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 284 | 1 | 2 | 4 | 2.0 | O=C(O)c1cc2cc(Br)c(O)cc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 137632781 | 156378 | None | 4 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 370 | 1 | 1 | 5 | 2.5 | O=c1oc2c(Br)cc(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4065291 | 156378 | None | 4 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 370 | 1 | 1 | 5 | 2.5 | O=c1oc2c(Br)cc(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 5491415 | 75318 | None | 18 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 537 | 6 | 8 | 10 | 1.7 | CC(=O)NCCc1ccc(O)c(-c2c(O)c(O)c3c(c2O)C(=O)c2c(cc(O)c(C(=O)O)c2C(=O)O)C3=O)c1 | 10.1021/ml2003058 | |||
| CHEMBL2037378 | 75318 | None | 18 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 537 | 6 | 8 | 10 | 1.7 | CC(=O)NCCc1ccc(O)c(-c2c(O)c(O)c3c(c2O)C(=O)c2c(cc(O)c(C(=O)O)c2C(=O)O)C3=O)c1 | 10.1021/ml2003058 | |||
| 2918 | 2204 | None | 75 | Human | Binding | pIC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 10.1016/j.bmcl.2016.12.012 | |||
| 3845 | 2204 | None | 75 | Human | Binding | pIC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 10.1016/j.bmcl.2016.12.012 | |||
| CHEMBL299155 | 2204 | None | 75 | Human | Binding | pIC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 10.1016/j.bmcl.2016.12.012 | |||
| DB11937 | 2204 | None | 75 | Human | Binding | pIC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 189 | 1 | 2 | 2 | 1.2 | OC(=O)c1cc(=O)c2c([nH]1)cccc2 | 10.1016/j.bmcl.2016.12.012 | |||
| 171348957 | 194383 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 804 | 14 | 3 | 12 | 6.6 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL5285029 | 194383 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 804 | 14 | 3 | 12 | 6.6 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 73157 | 197815 | None | 27 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 456 | 10 | 2 | 7 | 5.5 | CCCCCc1c2c(cc(O)c1C(=O)O)OC(=O)c1c(cc(OC)cc1C(=O)CCCC)O2 | 10.1021/ml2003058 | |||
| CHEMBL551842 | 197815 | None | 27 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 456 | 10 | 2 | 7 | 5.5 | CCCCCc1c2c(cc(O)c1C(=O)O)OC(=O)c1c(cc(OC)cc1C(=O)CCCC)O2 | 10.1021/ml2003058 | |||
| 1231538 | 27526 | None | 29 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 523 | 6 | 1 | 6 | 6.0 | O=C(Nc1ccc2nc(SCc3ccc(Cl)cc3)sc2c1)c1ccccc1C(=O)N1CCOCC1 | 10.1016/j.bmcl.2016.12.012 | |||
| CHEMBL1368962 | 27526 | None | 29 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 523 | 6 | 1 | 6 | 6.0 | O=C(Nc1ccc2nc(SCc3ccc(Cl)cc3)sc2c1)c1ccccc1C(=O)N1CCOCC1 | 10.1016/j.bmcl.2016.12.012 | |||
| 137657450 | 159689 | None | 4 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 400 | 2 | 1 | 6 | 2.5 | COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1Br | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4103143 | 159689 | None | 4 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 400 | 2 | 1 | 6 | 2.5 | COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1Br | 10.1021/acs.jmedchem.6b01431 | |||
| 3884 | 44512 | None | 53 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 242 | 2 | 1 | 3 | 3.2 | CC(C)=CCC1=C(O)C(=O)c2ccccc2C1=O | 10.1021/ml2003058 | |||
| CHEMBL15193 | 44512 | None | 53 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 242 | 2 | 1 | 3 | 3.2 | CC(C)=CCC1=C(O)C(=O)c2ccccc2C1=O | 10.1021/ml2003058 | |||
| 137641148 | 157139 | None | 4 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 308 | 1 | 2 | 6 | 1.4 | O=c1oc2cc(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4073902 | 157139 | None | 4 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 308 | 1 | 2 | 6 | 1.4 | O=c1oc2cc(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 171348957 | 194383 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 804 | 14 | 3 | 12 | 6.6 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL5285029 | 194383 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 804 | 14 | 3 | 12 | 6.6 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 20486870 | 61117 | None | 4 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 214 | 1 | 1 | 5 | 1.0 | O=c1oc2ccccc2cc1-c1nn[nH]n1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL1765162 | 61117 | None | 4 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 214 | 1 | 1 | 5 | 1.0 | O=c1oc2ccccc2cc1-c1nn[nH]n1 | 10.1021/acs.jmedchem.6b01431 | |||
| 2286812 | 29474 | None | 32 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 482 | 8 | 3 | 6 | 4.7 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)c(O)c2)C1=O)=C\c1ccccc1 | 10.1021/jm4009373 | |||
| CHEMBL1384502 | 29474 | None | 32 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 482 | 8 | 3 | 6 | 4.7 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)c(O)c2)C1=O)=C\c1ccccc1 | 10.1021/jm4009373 | |||
| 137646699 | 157829 | None | 0 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 555 | 6 | 1 | 7 | 4.6 | O=C(Nc1ccc2nc(S(=O)(=O)Cc3ccc(Cl)cc3)sc2c1)c1ccccc1C(=O)N1CCOCC1 | 10.1016/j.bmcl.2016.12.012 | |||
| CHEMBL4082295 | 157829 | None | 0 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 555 | 6 | 1 | 7 | 4.6 | O=C(Nc1ccc2nc(S(=O)(=O)Cc3ccc(Cl)cc3)sc2c1)c1ccccc1C(=O)N1CCOCC1 | 10.1016/j.bmcl.2016.12.012 | |||
| 171356399 | 194234 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 790 | 13 | 3 | 12 | 6.2 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL5281778 | 194234 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 790 | 13 | 3 | 12 | 6.2 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 13950958 | 157720 | None | 4 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 362 | 1 | 2 | 4 | 2.7 | O=C(O)c1cc2cc(Br)c(O)c(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4081238 | 157720 | None | 4 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 362 | 1 | 2 | 4 | 2.7 | O=C(O)c1cc2cc(Br)c(O)c(Br)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 2745687 | 933 | None | 27 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 10.1021/jm4009373 | |||
| 9741 | 933 | None | 27 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 10.1021/jm4009373 | |||
| CHEMBL1708510 | 933 | None | 27 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 10.1021/jm4009373 | |||
| 137654727 | 158837 | None | 4 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 357 | 1 | 0 | 4 | 3.2 | COc1c(Br)cc2cc(C#N)c(=O)oc2c1Br | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4093683 | 158837 | None | 4 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 357 | 1 | 0 | 4 | 3.2 | COc1c(Br)cc2cc(C#N)c(=O)oc2c1Br | 10.1021/acs.jmedchem.6b01431 | |||
| 137632988 | 156459 | None | 4 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 294 | 1 | 0 | 5 | 2.3 | N#Cc1cc2cc(Br)cc([N+](=O)[O-])c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4066109 | 156459 | None | 4 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 294 | 1 | 0 | 5 | 2.3 | N#Cc1cc2cc(Br)cc([N+](=O)[O-])c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 171345773 | 194513 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 806 | 14 | 3 | 13 | 5.4 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCOCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL5288015 | 194513 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 806 | 14 | 3 | 13 | 5.4 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCOCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 5346366 | 41511 | None | 4 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 489 | 6 | 1 | 6 | 5.3 | O=C(Nc1ccc2nc(SCc3ccccc3)sc2c1)c1ccccc1C(=O)N1CCOCC1 | 10.1016/j.bmcl.2016.12.012 | |||
| CHEMBL1490915 | 41511 | None | 4 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 489 | 6 | 1 | 6 | 5.3 | O=C(Nc1ccc2nc(SCc3ccccc3)sc2c1)c1ccccc1C(=O)N1CCOCC1 | 10.1016/j.bmcl.2016.12.012 | |||
| 137658472 | 159894 | None | 4 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 376 | 2 | 1 | 4 | 3.0 | COc1c(Br)cc2cc(C(=O)O)c(=O)oc2c1Br | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4105535 | 159894 | None | 4 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 376 | 2 | 1 | 4 | 3.0 | COc1c(Br)cc2cc(C(=O)O)c(=O)oc2c1Br | 10.1021/acs.jmedchem.6b01431 | |||
| 171345773 | 194513 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 806 | 14 | 3 | 13 | 5.4 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCOCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL5288015 | 194513 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 806 | 14 | 3 | 13 | 5.4 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCOCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 137662152 | 159485 | None | 11 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 353 | 2 | 2 | 8 | 1.3 | O=c1oc2c([N+](=O)[O-])c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4100677 | 159485 | None | 11 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 353 | 2 | 2 | 8 | 1.3 | O=c1oc2c([N+](=O)[O-])c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acs.jmedchem.6b01431 | |||
| 5066064 | 157464 | None | 5 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 239 | 0 | 0 | 3 | 3.0 | N#Cc1cc2cc(Cl)cc(Cl)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4078055 | 157464 | None | 5 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 239 | 0 | 0 | 3 | 3.0 | N#Cc1cc2cc(Cl)cc(Cl)c2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 171356399 | 194234 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 790 | 13 | 3 | 12 | 6.2 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL5281778 | 194234 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 790 | 13 | 3 | 12 | 6.2 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 171351254 | 194562 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 776 | 12 | 3 | 12 | 5.8 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL5289040 | 194562 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 776 | 12 | 3 | 12 | 5.8 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 137643561 | 158144 | None | 4 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 265 | 0 | 1 | 4 | 2.1 | N#Cc1cc2cc(Br)c(O)cc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| CHEMBL4085935 | 158144 | None | 4 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 265 | 0 | 1 | 4 | 2.1 | N#Cc1cc2cc(Br)c(O)cc2oc1=O | 10.1021/acs.jmedchem.6b01431 | |||
| 71733843 | 90890 | None | 7 | Human | Binding | pKd | = | 6.9 | 6.9 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392174 | 90890 | None | 7 | Human | Binding | pKd | = | 6.9 | 6.9 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2425818 | 90890 | None | 7 | Human | Binding | pKd | = | 6.9 | 6.9 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 171345773 | 194513 | None | 0 | Human | Binding | pKd | = | 7.8 | 7.8 | - | 1 | ChEMBL | 806 | 14 | 3 | 13 | 5.4 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCOCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL5288015 | 194513 | None | 0 | Human | Binding | pKd | = | 7.8 | 7.8 | - | 1 | ChEMBL | 806 | 14 | 3 | 13 | 5.4 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCOCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 171356399 | 194234 | None | 0 | Human | Binding | pKd | = | 8.4 | 8.4 | - | 1 | ChEMBL | 790 | 13 | 3 | 12 | 6.2 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL5281778 | 194234 | None | 0 | Human | Binding | pKd | = | 8.4 | 8.4 | - | 1 | ChEMBL | 790 | 13 | 3 | 12 | 6.2 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 71733843 | 90890 | None | 7 | Human | Binding | pKd | = | 8.3 | 8.3 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392174 | 90890 | None | 7 | Human | Binding | pKd | = | 8.3 | 8.3 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2425818 | 90890 | None | 7 | Human | Binding | pKd | = | 8.3 | 8.3 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 71733843 | 90890 | None | 7 | Human | Binding | pKd | = | 8.3 | 8.3 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392174 | 90890 | None | 7 | Human | Binding | pKd | = | 8.3 | 8.3 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2425818 | 90890 | None | 7 | Human | Binding | pKd | = | 8.3 | 8.3 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 71733843 | 90890 | None | 7 | Human | Binding | pKd | = | 8.2 | 8.2 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392174 | 90890 | None | 7 | Human | Binding | pKd | = | 8.2 | 8.2 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2425818 | 90890 | None | 7 | Human | Binding | pKd | = | 8.2 | 8.2 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 171351254 | 194562 | None | 0 | Human | Binding | pKd | = | 8.1 | 8.1 | - | 1 | ChEMBL | 776 | 12 | 3 | 12 | 5.8 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL5289040 | 194562 | None | 0 | Human | Binding | pKd | = | 8.1 | 8.1 | - | 1 | ChEMBL | 776 | 12 | 3 | 12 | 5.8 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 171348957 | 194383 | None | 0 | Human | Binding | pKd | = | 8.1 | 8.1 | - | 1 | ChEMBL | 804 | 14 | 3 | 12 | 6.6 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL5285029 | 194383 | None | 0 | Human | Binding | pKd | = | 8.1 | 8.1 | - | 1 | ChEMBL | 804 | 14 | 3 | 12 | 6.6 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCn3cc(CCCCCOc4cc(C(=O)O)nc5c(C)c6nc(C(=O)O)cc(O)c6cc45)nn3)cc1)c1nc(C)cn1[B-]2(F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 73294508 | 1140 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 453 | 4 | 2 | 5 | 3.8 | COc1cc(F)c(c(c1)F)C(=O)Nc1cc(Br)cc2c1oc(cc2=O)C(=O)O | 10.1021/jm4009373 | |||
| 9742 | 1140 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 453 | 4 | 2 | 5 | 3.8 | COc1cc(F)c(c(c1)F)C(=O)Nc1cc(Br)cc2c1oc(cc2=O)C(=O)O | 10.1021/jm4009373 | |||
| CHEMBL2425821 | 1140 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 453 | 4 | 2 | 5 | 3.8 | COc1cc(F)c(c(c1)F)C(=O)Nc1cc(Br)cc2c1oc(cc2=O)C(=O)O | 10.1021/jm4009373 | |||
| 71733748 | 90887 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | 10.1021/jm4009373 | |||
| CHEMBL2392171 | 90887 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | 10.1021/jm4009373 | |||
| 71733848 | 90895 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 451 | 4 | 2 | 5 | 4.2 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(Cl)c1 | 10.1021/jm4009373 | |||
| CHEMBL2392179 | 90895 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 451 | 4 | 2 | 5 | 4.2 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(Cl)c1 | 10.1021/jm4009373 | |||
| 73294320 | 92250 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 435 | 4 | 2 | 5 | 3.7 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(F)c1 | 10.1021/jm4009373 | |||
| CHEMBL2425819 | 92250 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 435 | 4 | 2 | 5 | 3.7 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(F)c1 | 10.1021/jm4009373 | |||
| 73294321 | 92251 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 435 | 4 | 2 | 5 | 3.7 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1F | 10.1021/jm4009373 | |||
| CHEMBL2425820 | 92251 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 435 | 4 | 2 | 5 | 3.7 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1F | 10.1021/jm4009373 | |||
| 73294319 | 92254 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 391 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)c(F)c1 | 10.1021/jm4009373 | |||
| CHEMBL2425824 | 92254 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 391 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)c(F)c1 | 10.1021/jm4009373 | |||
| 145971442 | 163122 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL4175848 | 163122 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)ccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.2c00461 | |||
| 2920 | 2997 | None | 64 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 54742459 | 2997 | None | 64 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 8546 | 2997 | None | 64 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL177880 | 2997 | None | 64 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 71735035 | 90872 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.8 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc(C(F)(F)F)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392156 | 90872 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | - | 1 | ChEMBL | 377 | 3 | 2 | 4 | 3.8 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc(C(F)(F)F)cc1 | 10.1021/jm4009373 | |||
| 2920 | 2997 | None | 64 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm4009373 | |||
| 54742459 | 2997 | None | 64 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm4009373 | |||
| 8546 | 2997 | None | 64 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm4009373 | |||
| CHEMBL177880 | 2997 | None | 64 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/jm4009373 | |||
| 71733650 | 90877 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(F)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm4009373 | |||
| CHEMBL2392161 | 90877 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(F)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm4009373 | |||
| 71733648 | 90875 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(O)c1cc(=O)c2cc(F)cc(NC(=O)c3cccc(Cl)c3Cl)c2o1 | 10.1021/jm4009373 | |||
| CHEMBL2392159 | 90875 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(O)c1cc(=O)c2cc(F)cc(NC(=O)c3cccc(Cl)c3Cl)c2o1 | 10.1021/jm4009373 | |||
| 71733746 | 90885 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 401 | 3 | 2 | 4 | 3.8 | Cc1cccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm4009373 | |||
| CHEMBL2392169 | 90885 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 401 | 3 | 2 | 4 | 3.8 | Cc1cccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm4009373 | |||
| 21982642 | 90859 | None | 0 | Human | Binding | pKi | = | 4.9 | 4.9 | - | 1 | ChEMBL | 235 | 2 | 1 | 5 | 1.4 | O=C(O)c1cc(=O)c2cccc([N+](=O)[O-])c2o1 | 10.1021/jm4009373 | |||
| CHEMBL2392142 | 90859 | None | 0 | Human | Binding | pKi | = | 4.9 | 4.9 | - | 1 | ChEMBL | 235 | 2 | 1 | 5 | 1.4 | O=C(O)c1cc(=O)c2cccc([N+](=O)[O-])c2o1 | 10.1021/jm4009373 | |||
| 71733652 | 90880 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 343 | 3 | 2 | 4 | 3.4 | O=C(Nc1cc(Cl)cc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm4009373 | |||
| CHEMBL2392164 | 90880 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 343 | 3 | 2 | 4 | 3.4 | O=C(Nc1cc(Cl)cc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm4009373 | |||
| 2920 | 2997 | None | 64 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 54742459 | 2997 | None | 64 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 8546 | 2997 | None | 64 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL177880 | 2997 | None | 64 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 71733842 | 90889 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 412 | 3 | 2 | 5 | 3.4 | N#Cc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392173 | 90889 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 412 | 3 | 2 | 5 | 3.4 | N#Cc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 71733847 | 90894 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 431 | 3 | 2 | 6 | 3.2 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc2c(c1)OCO2 | 10.1021/jm4009373 | |||
| CHEMBL2392178 | 90894 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 431 | 3 | 2 | 6 | 3.2 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc2c(c1)OCO2 | 10.1021/jm4009373 | |||
| 71733743 | 90882 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 388 | 4 | 2 | 6 | 3.3 | O=C(Nc1cc(Cl)cc2c(=O)cc(C(=O)O)oc12)c1ccc([N+](=O)[O-])cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392166 | 90882 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 388 | 4 | 2 | 6 | 3.3 | O=C(Nc1cc(Cl)cc2c(=O)cc(C(=O)O)oc12)c1ccc([N+](=O)[O-])cc1 | 10.1021/jm4009373 | |||
| 71734941 | 90861 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | - | 1 | ChEMBL | 247 | 2 | 2 | 4 | 1.5 | CC(=O)Nc1cccc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm4009373 | |||
| CHEMBL2392145 | 90861 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | - | 1 | ChEMBL | 247 | 2 | 2 | 4 | 1.5 | CC(=O)Nc1cccc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm4009373 | |||
| 71734943 | 90863 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | - | 1 | ChEMBL | 305 | 4 | 2 | 6 | 1.0 | COC(=O)CC(=O)Nc1cccc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm4009373 | |||
| CHEMBL2392147 | 90863 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | - | 1 | ChEMBL | 305 | 4 | 2 | 6 | 1.0 | COC(=O)CC(=O)Nc1cccc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm4009373 | |||
| 71734940 | 90879 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 385 | 5 | 1 | 6 | 3.4 | CCOC(=O)c1cc(=O)c2cc(F)cc(NC(=O)c3ccc(OC)cc3)c2o1 | 10.1021/jm4009373 | |||
| CHEMBL2392163 | 90879 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 385 | 5 | 1 | 6 | 3.4 | CCOC(=O)c1cc(=O)c2cc(F)cc(NC(=O)c3ccc(OC)cc3)c2o1 | 10.1021/jm4009373 | |||
| 71733749 | 90888 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm4009373 | |||
| CHEMBL2392172 | 90888 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 455 | 3 | 2 | 4 | 4.8 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)c(Cl)c1 | 10.1021/jm4009373 | |||
| 73294510 | 92253 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | - | 1 | ChEMBL | 369 | 5 | 2 | 6 | 2.8 | COc1ccc(C(=O)Nc2cc(OC)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2425823 | 92253 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | - | 1 | ChEMBL | 369 | 5 | 2 | 6 | 2.8 | COc1ccc(C(=O)Nc2cc(OC)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 71735036 | 90873 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 339 | 4 | 2 | 5 | 2.8 | COc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392157 | 90873 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 339 | 4 | 2 | 5 | 2.8 | COc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 71733846 | 90893 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 447 | 5 | 2 | 6 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1OC | 10.1021/jm4009373 | |||
| CHEMBL2392177 | 90893 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 447 | 5 | 2 | 6 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1OC | 10.1021/jm4009373 | |||
| 2920 | 2997 | None | 64 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 54742459 | 2997 | None | 64 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 8546 | 2997 | None | 64 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL177880 | 2997 | None | 64 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 71733647 | 90874 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 387 | 3 | 2 | 4 | 3.5 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc(Br)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392158 | 90874 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 387 | 3 | 2 | 4 | 3.5 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc(Br)cc1 | 10.1021/jm4009373 | |||
| 2882 | 1208 | None | 41 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm4009373 | |||
| 741 | 1208 | None | 41 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm4009373 | |||
| 7608 | 1208 | None | 41 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm4009373 | |||
| CHEMBL428880 | 1208 | None | 41 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm4009373 | |||
| DB01003 | 1208 | None | 41 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/jm4009373 | |||
| 2745687 | 933 | None | 27 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 9741 | 933 | None | 27 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL1708510 | 933 | None | 27 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 10.1021/acsmedchemlett.2c00461 | |||
| 71733651 | 90878 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 357 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(F)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392162 | 90878 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 357 | 4 | 2 | 5 | 2.9 | COc1ccc(C(=O)Nc2cc(F)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 71733940 | 90899 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 418 | 4 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cn1 | 10.1021/jm4009373 | |||
| CHEMBL2392183 | 90899 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 418 | 4 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cn1 | 10.1021/jm4009373 | |||
| 71733653 | 90881 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.7 | Cc1cccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm4009373 | |||
| CHEMBL2392165 | 90881 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 357 | 3 | 2 | 4 | 3.7 | Cc1cccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm4009373 | |||
| 71734945 | 90866 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 323 | 4 | 2 | 4 | 2.7 | O=C(Cc1ccccc1)Nc1cccc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm4009373 | |||
| CHEMBL2392150 | 90866 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 323 | 4 | 2 | 4 | 2.7 | O=C(Cc1ccccc1)Nc1cccc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm4009373 | |||
| 154634314 | 186715 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccccc1-c1cc2cc(C(=O)O)c(=O)oc2c2cc(C(=O)O)c(=O)oc12 | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL4878979 | 186715 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 408 | 4 | 2 | 7 | 3.0 | COc1ccccc1-c1cc2cc(C(=O)O)c(=O)oc2c2cc(C(=O)O)c(=O)oc12 | 10.1021/acsmedchemlett.2c00461 | |||
| 2882 | 1208 | None | 41 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 741 | 1208 | None | 41 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 7608 | 1208 | None | 41 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL428880 | 1208 | None | 41 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| DB01003 | 1208 | None | 41 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 71734939 | 90860 | None | 1 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 283 | 1 | 2 | 4 | 1.8 | Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm4009373 | |||
| CHEMBL2392144 | 90860 | None | 1 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 283 | 1 | 2 | 4 | 1.8 | Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm4009373 | |||
| 118985385 | 1701 | None | 63 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | |||
| 1258 | 1701 | None | 63 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | |||
| 3440 | 1701 | None | 63 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | |||
| 4839 | 1701 | None | 63 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | |||
| CHEMBL35 | 1701 | None | 63 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | |||
| DB00695 | 1701 | None | 63 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | 10.1021/jm4009373 | |||
| 71735031 | 90865 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 309 | 3 | 2 | 4 | 2.7 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm4009373 | |||
| CHEMBL2392149 | 90865 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 309 | 3 | 2 | 4 | 2.7 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm4009373 | |||
| 71733845 | 90892 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccccc1C(=O)Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm4009373 | |||
| CHEMBL2392176 | 90892 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccccc1C(=O)Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm4009373 | |||
| 1024 | 16495 | None | 63 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 330 | 3 | 4 | 6 | 0.6 | O=C(O)c1cc(C(=O)O)c2c(n1)C(=O)C(=O)c1cc(C(=O)O)[nH]c1-2 | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL1235421 | 16495 | None | 63 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 330 | 3 | 4 | 6 | 0.6 | O=C(O)c1cc(C(=O)O)c2c(n1)C(=O)C(=O)c1cc(C(=O)O)[nH]c1-2 | 10.1021/acsmedchemlett.2c00461 | |||
| 13950958 | 157720 | None | 4 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 362 | 1 | 2 | 4 | 2.7 | O=C(O)c1cc2cc(Br)c(O)c(Br)c2oc1=O | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL4081238 | 157720 | None | 4 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 362 | 1 | 2 | 4 | 2.7 | O=C(O)c1cc2cc(Br)c(O)c(Br)c2oc1=O | 10.1021/acsmedchemlett.2c00461 | |||
| 71734944 | 90864 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 315 | 3 | 2 | 4 | 3.0 | O=C(O)c1cc(=O)c2cccc(NC(=O)C3CCCCC3)c2o1 | 10.1021/jm4009373 | |||
| CHEMBL2392148 | 90864 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 315 | 3 | 2 | 4 | 3.0 | O=C(O)c1cc(=O)c2cccc(NC(=O)C3CCCCC3)c2o1 | 10.1021/jm4009373 | |||
| 4488 | 205479 | None | 66 | Human | Binding | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | 10.1021/jm4009373 | |||
| CHEMBL63323 | 205479 | None | 66 | Human | Binding | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | 10.1021/jm4009373 | |||
| 71733937 | 90896 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 379 | 6 | 2 | 5 | 3.5 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc(OCC2CC2)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392180 | 90896 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 379 | 6 | 2 | 5 | 3.5 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc(OCC2CC2)cc1 | 10.1021/jm4009373 | |||
| 54676038 | 38734 | None | 51 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 336 | 2 | 2 | 6 | 2.9 | O=c1oc2ccccc2c(O)c1Cc1c(O)c2ccccc2oc1=O | 10.1021/jm4009373 | |||
| CHEMBL1466 | 38734 | None | 51 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 336 | 2 | 2 | 6 | 2.9 | O=c1oc2ccccc2c(O)c1Cc1c(O)c2ccccc2oc1=O | 10.1021/jm4009373 | |||
| 2286812 | 29474 | None | 32 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 482 | 8 | 3 | 6 | 4.7 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)c(O)c2)C1=O)=C\c1ccccc1 | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL1384502 | 29474 | None | 32 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 482 | 8 | 3 | 6 | 4.7 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)c(O)c2)C1=O)=C\c1ccccc1 | 10.1021/acsmedchemlett.2c00461 | |||
| 71733649 | 90876 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(O)c1cc(=O)c2cc(F)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | 10.1021/jm4009373 | |||
| CHEMBL2392160 | 90876 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 395 | 3 | 2 | 4 | 4.2 | O=C(O)c1cc(=O)c2cc(F)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | 10.1021/jm4009373 | |||
| 71733747 | 90886 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 421 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392170 | 90886 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 421 | 3 | 2 | 4 | 4.2 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccc(Cl)cc1 | 10.1021/jm4009373 | |||
| 135399235 | 4134 | None | 41 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm4009373 | |||
| 2919 | 4134 | None | 41 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm4009373 | |||
| 5722 | 4134 | None | 41 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm4009373 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/jm4009373 | |||
| 2745687 | 933 | None | 27 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 10.1021/jm4009373 | |||
| 9741 | 933 | None | 27 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 10.1021/jm4009373 | |||
| CHEMBL1708510 | 933 | None | 27 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 10.1021/jm4009373 | |||
| 73294509 | 92252 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 353 | 4 | 2 | 5 | 3.1 | COc1ccc(C(=O)Nc2cc(C)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2425822 | 92252 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 353 | 4 | 2 | 5 | 3.1 | COc1ccc(C(=O)Nc2cc(C)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 71735033 | 90870 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 354 | 4 | 2 | 6 | 2.7 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1cccc([N+](=O)[O-])c1 | 10.1021/jm4009373 | |||
| CHEMBL2392154 | 90870 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 354 | 4 | 2 | 6 | 2.7 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1cccc([N+](=O)[O-])c1 | 10.1021/jm4009373 | |||
| 71735032 | 90869 | None | 0 | Human | Binding | pKi | = | 5.3 | 5.3 | - | 1 | ChEMBL | 323 | 3 | 2 | 4 | 3.1 | Cc1cccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm4009373 | |||
| CHEMBL2392153 | 90869 | None | 0 | Human | Binding | pKi | = | 5.3 | 5.3 | - | 1 | ChEMBL | 323 | 3 | 2 | 4 | 3.1 | Cc1cccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)c1 | 10.1021/jm4009373 | |||
| 71733843 | 90890 | None | 7 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392174 | 90890 | None | 7 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2425818 | 90890 | None | 7 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 417 | 4 | 2 | 5 | 3.5 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 71733744 | 90883 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 3.4 | COc1ccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392167 | 90883 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 373 | 4 | 2 | 5 | 3.4 | COc1ccc(C(=O)Nc2cc(Cl)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 2295463 | 92255 | None | 29 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 279 | 4 | 2 | 5 | 1.5 | O=C(O)COc1ccc(/C=C2\SC(=O)NC2=O)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2425825 | 92255 | None | 29 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 279 | 4 | 2 | 5 | 1.5 | O=C(O)COc1ccc(/C=C2\SC(=O)NC2=O)cc1 | 10.1021/jm4009373 | |||
| 137662152 | 159485 | None | 11 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 353 | 2 | 2 | 8 | 1.3 | O=c1oc2c([N+](=O)[O-])c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL4100677 | 159485 | None | 11 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 353 | 2 | 2 | 8 | 1.3 | O=c1oc2c([N+](=O)[O-])c(O)c(Br)cc2cc1-c1nnn[nH]1 | 10.1021/acsmedchemlett.2c00461 | |||
| 71733939 | 90898 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 418 | 4 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)nc1 | 10.1021/jm4009373 | |||
| CHEMBL2392182 | 90898 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 418 | 4 | 2 | 6 | 2.9 | COc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)nc1 | 10.1021/jm4009373 | |||
| 326869 | 112874 | None | 2 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 314 | 2 | 4 | 4 | 1.1 | Cc1c2[nH]c(C(=O)O)cc(=O)c2cc2c(=O)cc(C(=O)O)[nH]c12 | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL3306990 | 112874 | None | 2 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 314 | 2 | 4 | 4 | 1.1 | Cc1c2[nH]c(C(=O)O)cc(=O)c2cc2c(=O)cc(C(=O)O)[nH]c12 | 10.1021/acsmedchemlett.2c00461 | |||
| 135399235 | 4134 | None | 41 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acsmedchemlett.2c00461 | |||
| 2919 | 4134 | None | 41 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acsmedchemlett.2c00461 | |||
| 5722 | 4134 | None | 41 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL28079 | 4134 | None | 41 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 271 | 4 | 2 | 5 | 1.4 | CCCOc1ccccc1c1nc(=O)c2c(n1)[nH][nH]n2 | 10.1021/acsmedchemlett.2c00461 | |||
| 12138435 | 68079 | None | 26 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 329 | 1 | 0 | 4 | 4.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1 | 10.1021/jm4009373 | |||
| CHEMBL1914576 | 68079 | None | 26 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 329 | 1 | 0 | 4 | 4.4 | CC1=C(C#N)C(=C(C#N)C#N)OC1(C)c1ccc(Cl)c(Cl)c1 | 10.1021/jm4009373 | |||
| 71734942 | 90862 | None | 0 | Human | Binding | pKi | = | 5.2 | 5.2 | - | 1 | ChEMBL | 261 | 3 | 2 | 4 | 1.8 | CCC(=O)Nc1cccc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm4009373 | |||
| CHEMBL2392146 | 90862 | None | 0 | Human | Binding | pKi | = | 5.2 | 5.2 | - | 1 | ChEMBL | 261 | 3 | 2 | 4 | 1.8 | CCC(=O)Nc1cccc2c(=O)cc(C(=O)O)oc12 | 10.1021/jm4009373 | |||
| 71735030 | 90868 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 360 | 3 | 2 | 5 | 3.3 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccccc2n1 | 10.1021/jm4009373 | |||
| CHEMBL2392152 | 90868 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 360 | 3 | 2 | 5 | 3.3 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccccc2n1 | 10.1021/jm4009373 | |||
| 71735034 | 90871 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 323 | 3 | 2 | 4 | 3.1 | Cc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392155 | 90871 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 323 | 3 | 2 | 4 | 3.1 | Cc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 71734946 | 90867 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 359 | 3 | 2 | 4 | 3.9 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccccc2c1 | 10.1021/jm4009373 | |||
| CHEMBL2392151 | 90867 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 359 | 3 | 2 | 4 | 3.9 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccccc2c1 | 10.1021/jm4009373 | |||
| 2286812 | 29474 | None | 32 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 482 | 8 | 3 | 6 | 4.7 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)c(O)c2)C1=O)=C\c1ccccc1 | 10.1021/jm4009373 | |||
| CHEMBL1384502 | 29474 | None | 32 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 482 | 8 | 3 | 6 | 4.7 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)c(O)c2)C1=O)=C\c1ccccc1 | 10.1021/jm4009373 | |||
| 2920 | 2997 | None | 64 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 54742459 | 2997 | None | 64 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 8546 | 2997 | None | 64 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL177880 | 2997 | None | 64 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 71733938 | 90897 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 367 | 6 | 2 | 5 | 3.5 | CCCOc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392181 | 90897 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 367 | 6 | 2 | 5 | 3.5 | CCCOc1ccc(C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 71733745 | 90884 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 387 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm4009373 | |||
| CHEMBL2392168 | 90884 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 387 | 3 | 2 | 4 | 3.5 | O=C(Nc1cc(Br)cc2c(=O)cc(C(=O)O)oc12)c1ccccc1 | 10.1021/jm4009373 | |||
| 2920 | 2997 | None | 64 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 54742459 | 2997 | None | 64 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 8546 | 2997 | None | 64 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| CHEMBL177880 | 2997 | None | 64 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 388 | 4 | 4 | 4 | 4.4 | OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O | 10.1021/acsmedchemlett.2c00461 | |||
| 71733844 | 90891 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 431 | 5 | 2 | 5 | 3.9 | CCOc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| CHEMBL2392175 | 90891 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 431 | 5 | 2 | 5 | 3.9 | CCOc1ccc(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/jm4009373 | |||
| 92934 | 169760 | None | 56 | Human | Binding | pKi | = | 5.0 | 5.0 | - | 1 | ChEMBL | 280 | 2 | 2 | 6 | 1.9 | O=C(O)[C@H]1CSC(c2nc3ccc(O)cc3s2)=N1 | 10.1021/jm4009373 | |||
| CHEMBL443738 | 169760 | None | 56 | Human | Binding | pKi | = | 5.0 | 5.0 | - | 1 | ChEMBL | 280 | 2 | 2 | 6 | 1.9 | O=C(O)[C@H]1CSC(c2nc3ccc(O)cc3s2)=N1 | 10.1021/jm4009373 | |||
| 4488 | 205479 | None | 66 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Drug Central | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | None | |||
| CHEMBL63323 | 205479 | None | 66 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Drug Central | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1cccnc1Nc1cccc(C(F)(F)F)c1 | None | |||
| 118985385 | 1701 | None | 63 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Drug Central | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | None | |||
| 1258 | 1701 | None | 63 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Drug Central | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | None | |||
| 3440 | 1701 | None | 63 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Drug Central | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | None | |||
| 4839 | 1701 | None | 63 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Drug Central | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | None | |||
| CHEMBL35 | 1701 | None | 63 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Drug Central | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | None | |||
| DB00695 | 1701 | None | 63 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Drug Central | 330 | 5 | 3 | 5 | 1.9 | OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N | None | |||
| 2882 | 1208 | None | 41 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Drug Central | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | None | |||
| 741 | 1208 | None | 41 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Drug Central | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | None | |||
| 7608 | 1208 | None | 41 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Drug Central | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | None | |||
| CHEMBL428880 | 1208 | None | 41 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Drug Central | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | None | |||
| DB01003 | 1208 | None | 41 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Drug Central | 468 | 8 | 3 | 9 | 2.1 | OC(COc1cccc2c1c(=O)cc(o2)C(=O)O)COc1cccc2c1c(=O)cc(o2)C(=O)O | None | |||
| 54676038 | 38734 | None | 51 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | Drug Central | 336 | 2 | 2 | 6 | 2.9 | O=c1oc2ccccc2c(O)c1Cc1c(O)c2ccccc2oc1=O | None | |||
| CHEMBL1466 | 38734 | None | 51 | Human | Binding | pKi | = | 8.1 | 8.1 | - | 1 | Drug Central | 336 | 2 | 2 | 6 | 2.9 | O=c1oc2ccccc2c(O)c1Cc1c(O)c2ccccc2oc1=O | None | |||
| 2745687 | 933 | None | 27 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | Guide to Pharmacology | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 20826425 | |||
| 9741 | 933 | None | 27 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | Guide to Pharmacology | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 20826425 | |||
| CHEMBL1708510 | 933 | None | 27 | Human | Binding | pKi | = | 7.9 | 7.9 | - | 1 | Guide to Pharmacology | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 20826425 | |||
| 2745687 | 933 | None | 27 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | Guide to Pharmacology | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 23888932 | |||
| 9741 | 933 | None | 27 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | Guide to Pharmacology | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 23888932 | |||
| CHEMBL1708510 | 933 | None | 27 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | Guide to Pharmacology | 395 | 4 | 2 | 6 | 2.5 | COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F | 23888932 | |||
| 73294508 | 1140 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | Guide to Pharmacology | 453 | 4 | 2 | 5 | 3.8 | COc1cc(F)c(c(c1)F)C(=O)Nc1cc(Br)cc2c1oc(cc2=O)C(=O)O | 23888932 | |||
| 9742 | 1140 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | Guide to Pharmacology | 453 | 4 | 2 | 5 | 3.8 | COc1cc(F)c(c(c1)F)C(=O)Nc1cc(Br)cc2c1oc(cc2=O)C(=O)O | 23888932 | |||
| CHEMBL2425821 | 1140 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | - | 1 | Guide to Pharmacology | 453 | 4 | 2 | 5 | 3.8 | COc1cc(F)c(c(c1)F)C(=O)Nc1cc(Br)cc2c1oc(cc2=O)C(=O)O | 23888932 | |||