GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species		Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	56707820	2910	None	38	Human		Functional	pEC50	=	6.8	6.8	-	1	Affinity Phenotypic Cellular interaction (FLIPR-TETRA assay (proton-mediated calcium mobilization in HEK293T cells)) EUB0000354a GPR68Affinity Phenotypic Cellular interaction (FLIPR-TETRA assay (proton-mediated calcium mobilization in HEK293T cells)) EUB0000354a GPR68	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL5209897
	9155	2910	None	38	Human		Functional	pEC50	=	6.8	6.8	-	1	Affinity Phenotypic Cellular interaction (FLIPR-TETRA assay (proton-mediated calcium mobilization in HEK293T cells)) EUB0000354a GPR68Affinity Phenotypic Cellular interaction (FLIPR-TETRA assay (proton-mediated calcium mobilization in HEK293T cells)) EUB0000354a GPR68	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL5209897
	CHEMBL4548689	2910	None	38	Human		Functional	pEC50	=	6.8	6.8	-	1	Affinity Phenotypic Cellular interaction (FLIPR-TETRA assay (proton-mediated calcium mobilization in HEK293T cells)) EUB0000354a GPR68Affinity Phenotypic Cellular interaction (FLIPR-TETRA assay (proton-mediated calcium mobilization in HEK293T cells)) EUB0000354a GPR68	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL5209897
	10572	3148	None	0	Human		Functional	pEC50	=	5.9	5.9	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	31675498
	145996515	3148	None	0	Human		Functional	pEC50	=	5.9	5.9	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	31675498
	10571	802	None	0	Human		Functional	pEC50	=	6.0	6.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	31675498
	145996514	802	None	0	Human		Functional	pEC50	=	6.0	6.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	31675498
	10570	2971	None	0	Human		Functional	pEC50	=	6.4	6.4	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	31675498
	145996513	2971	None	0	Human		Functional	pEC50	=	6.4	6.4	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	31675498
	56707820	2910	None	38	Human		Functional	pKB	=	5.0	5.0	-	1	Allosteric ligand biochemical binding affinity in the presence of protons (H<sup>+</sup>. Affinity cannot be measured in the absence of endogenous ligand for this receptor.Allosteric ligand biochemical binding affinity in the presence of protons (H<sup>+</sup>. Affinity cannot be measured in the absence of endogenous ligand for this receptor.	Guide to Pharmacology	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	26550826
	9155	2910	None	38	Human		Functional	pKB	=	5.0	5.0	-	1	Allosteric ligand biochemical binding affinity in the presence of protons (H<sup>+</sup>. Affinity cannot be measured in the absence of endogenous ligand for this receptor.Allosteric ligand biochemical binding affinity in the presence of protons (H<sup>+</sup>. Affinity cannot be measured in the absence of endogenous ligand for this receptor.	Guide to Pharmacology	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	26550826
	CHEMBL4548689	2910	None	38	Human		Functional	pKB	=	5.0	5.0	-	1	Allosteric ligand biochemical binding affinity in the presence of protons (H<sup>+</sup>. Affinity cannot be measured in the absence of endogenous ligand for this receptor.Allosteric ligand biochemical binding affinity in the presence of protons (H<sup>+</sup>. Affinity cannot be measured in the absence of endogenous ligand for this receptor.	Guide to Pharmacology	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	26550826
	10440	2680	None	22	Human		Functional	pKB	=	5.9	5.9	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	31298539
	139030523	2680	None	22	Human		Functional	pKB	=	5.9	5.9	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	31298539
	CHEMBL4449712	2680	None	22	Human		Functional	pKB	=	5.9	5.9	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	31298539

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species		Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	56707820	2910	None	38	Human		Binding	pEC50	=	6.8	6.8	-	1	FLIPR-TETRA assayFLIPR-TETRA assay	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL4507323
	9155	2910	None	38	Human		Binding	pEC50	=	6.8	6.8	-	1	FLIPR-TETRA assayFLIPR-TETRA assay	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL4507323
	CHEMBL4548689	2910	None	38	Human		Binding	pEC50	=	6.8	6.8	-	1	FLIPR-TETRA assayFLIPR-TETRA assay	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL4507323