Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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ID		 Reference
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 Assay
Type

 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
118727607 117570 None 0 Human Functional pEC50 = 9.2 9.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 410 6 1 2 5.8 NC1(CN(C(=O)[C@@H]2C[C@H]2c2ccccc2)c2ccc(-c3ccccc3)cc2)CCCC1 10.1016/j.bmcl.2015.02.038
CHEMBL3400199 117570 None 0 Human Functional pEC50 = 9.2 9.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 410 6 1 2 5.8 NC1(CN(C(=O)[C@@H]2C[C@H]2c2ccccc2)c2ccc(-c3ccccc3)cc2)CCCC1 10.1016/j.bmcl.2015.02.038
118730169 118122 None 0 Human Functional pEC50 = 9.2 9.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 438 7 1 2 6.4 N[C@H](CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1)C1CCCCC1 10.1016/j.bmcl.2015.02.038
CHEMBL3404056 118122 None 0 Human Functional pEC50 = 9.2 9.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 438 7 1 2 6.4 N[C@H](CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1)C1CCCCC1 10.1016/j.bmcl.2015.02.038
118727606 117569 None 0 Human Functional pEC50 = 9.2 9.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 414 8 1 3 4.9 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400198 117569 None 0 Human Functional pEC50 = 9.2 9.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 414 8 1 3 4.9 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727605 117568 None 0 Human Functional pEC50 = 9.0 9.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 398 7 1 2 5.5 CC(C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400197 117568 None 0 Human Functional pEC50 = 9.0 9.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 398 7 1 2 5.5 CC(C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118730162 118115 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 414 9 1 2 5.9 CC(C)C[C@H](N)CN(C(=O)C(C)Cc1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3404049 118115 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 414 9 1 2 5.9 CC(C)C[C@H](N)CN(C(=O)C(C)Cc1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727608 117571 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 384 6 1 2 5.2 CC(C)(N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400200 117571 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 384 6 1 2 5.2 CC(C)(N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118730167 118120 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC[C@@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3404054 118120 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC[C@@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118730168 118121 None 0 Human Functional pEC50 = 8.8 8.8 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 452 8 1 2 6.8 N[C@@H](CC1CCCCC1)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3404055 118121 None 0 Human Functional pEC50 = 8.8 8.8 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 452 8 1 2 6.8 N[C@@H](CC1CCCCC1)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118730164 118117 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC(C)C[C@@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3404051 118117 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC(C)C[C@@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727610 117573 None 0 Human Functional pEC50 = 8 8.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 410 6 1 2 5.5 O=C([C@@H]1C[C@H]1c1ccccc1)N(CC1CCCNC1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400202 117573 None 0 Human Functional pEC50 = 8 8.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 410 6 1 2 5.5 O=C([C@@H]1C[C@H]1c1ccccc1)N(CC1CCCNC1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
12395 3411 None 1 Human Functional pEC50 = 8.0 8.0 14 2
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 491 10 1 5 5.2 N[C@@H]([C@@H](C)OC)CN(C(=O)[C@H]1[C@H](c2ccc(F)cn2)C1)c1ccc(c2ccc(OC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
167993640 3411 None 1 Human Functional pEC50 = 8.0 8.0 14 2
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 491 10 1 5 5.2 N[C@@H]([C@@H](C)OC)CN(C(=O)[C@H]1[C@H](c2ccc(F)cn2)C1)c1ccc(c2ccc(OC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5498825 3411 None 1 Human Functional pEC50 = 8.0 8.0 14 2
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 491 10 1 5 5.2 N[C@@H]([C@@H](C)OC)CN(C(=O)[C@H]1[C@H](c2ccc(F)cn2)C1)c1ccc(c2ccc(OC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
10031 3412 None 10 Human Functional pEC50 = 7 7.0 2 2
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
134813902 3412 None 10 Human Functional pEC50 = 7 7.0 2 2
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
CHEMBL4595209 3412 None 10 Human Functional pEC50 = 7 7.0 2 2
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
51356430 118057 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403768 118057 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51356141 118069 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 438 11 1 4 4.8 CCCC(C)COc1ccc([C@H](CN2CCOCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403783 118069 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 438 11 1 4 4.8 CCCC(C)COc1ccc([C@H](CN2CCOCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355601 133759 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 439 12 3 4 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3714989 133759 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 439 12 3 4 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355320 133787 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 438 14 2 3 6.1 CCCC(C)COc1ccc([C@H](CNCC(C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715058 133787 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 438 14 2 3 6.1 CCCC(C)COc1ccc([C@H](CNCC(C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51356142 133809 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 369 9 2 3 4.5 CC[C@H](C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)[C@@H](C)O)cc1 nan
CHEMBL3715126 133809 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 369 9 2 3 4.5 CC[C@H](C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)[C@@H](C)O)cc1 nan
51355319 133824 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 451 13 3 4 4.8 CCCC(C)COc1ccc([C@H](CNC[C@@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715177 133824 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 451 13 3 4 4.8 CCCC(C)COc1ccc([C@H](CNC[C@@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51356138 133851 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 425 13 3 4 4.4 CCCC(C)COc1ccc([C@H](CNC[C@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715294 133851 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 425 13 3 4 4.4 CCCC(C)COc1ccc([C@H](CNC[C@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
58466420 133891 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 385 11 3 4 3.4 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CO)c2ccccc2)cc1 nan
CHEMBL3715473 133891 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 385 11 3 4 3.4 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CO)c2ccccc2)cc1 nan
51356137 133930 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2cccnc2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715603 133930 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2cccnc2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355600 133936 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 467 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)CCC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715622 133936 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 467 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)CCC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51356431 134041 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 448 13 3 4 5.0 CCCC(C)COc1ccc([C@H](CNCc2cc[nH]n2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715982 134041 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 448 13 3 4 5.0 CCCC(C)COc1ccc([C@H](CNCc2cc[nH]n2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355324 134064 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 383 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CC)c2ccccc2)cc1 nan
CHEMBL3716055 134064 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 383 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CC)c2ccccc2)cc1 nan
51355879 134138 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 497 13 3 3 6.7 CCCC(C)COc1ccc([C@H](CNCc2c[nH]c3ccccc23)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716282 134138 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 497 13 3 3 6.7 CCCC(C)COc1ccc([C@H](CNCc2c[nH]c3ccccc23)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
58466410 134254 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 451 11 1 4 4.7 CCCC(C)COc1ccc(C(CN2CCN(C)CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716700 134254 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 451 11 1 4 4.7 CCCC(C)COc1ccc(C(CN2CCN(C)CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355602 134436 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 465 13 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)C2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717324 134436 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 465 13 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)C2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355878 134488 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 483 14 3 5 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@@H](C)OC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717488 134488 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 483 14 3 5 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@@H](C)OC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355882 134493 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 522 14 3 6 4.6 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)Cc2cscn2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717512 134493 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 522 14 3 6 4.6 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)Cc2cscn2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355321 134527 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717617 134527 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355881 134562 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)[C@@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717750 134562 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)[C@@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355322 134589 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2ccncc2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717835 134589 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2ccncc2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355597 134626 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 479 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CC2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717978 134626 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 479 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CC2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
58466403 134869 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 452 13 2 4 5.1 CCCC(C)COc1ccc([C@H](CNCC2CCOC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3718752 134869 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 452 13 2 4 5.1 CCCC(C)COc1ccc([C@H](CNCC2CCOC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355599 134965 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 396 12 2 3 5.1 CCCNC[C@H](NC(=O)[C@@H](C)c1ccccc1)c1ccc(OC[C@@H](C)CC)cc1 nan
CHEMBL3719078 134965 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 396 12 2 3 5.1 CCCNC[C@H](NC(=O)[C@@H](C)c1ccccc1)c1ccc(OC[C@@H](C)CC)cc1 nan
51356430 118057 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403768 118057 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51356141 118069 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 438 11 1 4 4.8 CCCC(C)COc1ccc([C@H](CN2CCOCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403783 118069 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 438 11 1 4 4.8 CCCC(C)COc1ccc([C@H](CN2CCOCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355601 133759 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 439 12 3 4 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3714989 133759 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 439 12 3 4 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355320 133787 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 438 14 2 3 6.1 CCCC(C)COc1ccc([C@H](CNCC(C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715058 133787 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 438 14 2 3 6.1 CCCC(C)COc1ccc([C@H](CNCC(C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51356142 133809 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 369 9 2 3 4.5 CC[C@H](C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)[C@@H](C)O)cc1 nan
CHEMBL3715126 133809 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 369 9 2 3 4.5 CC[C@H](C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)[C@@H](C)O)cc1 nan
51355319 133824 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 451 13 3 4 4.8 CCCC(C)COc1ccc([C@H](CNC[C@@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715177 133824 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 451 13 3 4 4.8 CCCC(C)COc1ccc([C@H](CNC[C@@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51356138 133851 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 425 13 3 4 4.4 CCCC(C)COc1ccc([C@H](CNC[C@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715294 133851 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 425 13 3 4 4.4 CCCC(C)COc1ccc([C@H](CNC[C@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
58466420 133891 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 385 11 3 4 3.4 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CO)c2ccccc2)cc1 nan
CHEMBL3715473 133891 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 385 11 3 4 3.4 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CO)c2ccccc2)cc1 nan
51356137 133930 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2cccnc2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715603 133930 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2cccnc2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355600 133936 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 467 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)CCC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715622 133936 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 467 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)CCC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51356431 134041 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 448 13 3 4 5.0 CCCC(C)COc1ccc([C@H](CNCc2cc[nH]n2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715982 134041 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 448 13 3 4 5.0 CCCC(C)COc1ccc([C@H](CNCc2cc[nH]n2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355324 134064 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 383 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CC)c2ccccc2)cc1 nan
CHEMBL3716055 134064 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 383 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CC)c2ccccc2)cc1 nan
51355879 134138 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 497 13 3 3 6.7 CCCC(C)COc1ccc([C@H](CNCc2c[nH]c3ccccc23)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716282 134138 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 497 13 3 3 6.7 CCCC(C)COc1ccc([C@H](CNCc2c[nH]c3ccccc23)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
58466410 134254 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 451 11 1 4 4.7 CCCC(C)COc1ccc(C(CN2CCN(C)CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716700 134254 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 451 11 1 4 4.7 CCCC(C)COc1ccc(C(CN2CCN(C)CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355602 134436 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 465 13 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)C2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717324 134436 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 465 13 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)C2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355878 134488 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 483 14 3 5 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@@H](C)OC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717488 134488 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 483 14 3 5 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@@H](C)OC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355882 134493 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 522 14 3 6 4.6 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)Cc2cscn2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717512 134493 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 522 14 3 6 4.6 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)Cc2cscn2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355321 134527 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717617 134527 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355881 134562 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)[C@@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717750 134562 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)[C@@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355322 134589 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2ccncc2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717835 134589 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2ccncc2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355597 134626 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 479 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CC2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717978 134626 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 479 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CC2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
58466403 134869 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 452 13 2 4 5.1 CCCC(C)COc1ccc([C@H](CNCC2CCOC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3718752 134869 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 452 13 2 4 5.1 CCCC(C)COc1ccc([C@H](CNCC2CCOC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355599 134965 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 396 12 2 3 5.1 CCCNC[C@H](NC(=O)[C@@H](C)c1ccccc1)c1ccc(OC[C@@H](C)CC)cc1 nan
CHEMBL3719078 134965 None 0 Human Functional pEC50 = 7 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 396 12 2 3 5.1 CCCNC[C@H](NC(=O)[C@@H](C)c1ccccc1)c1ccc(OC[C@@H](C)CC)cc1 nan
162659346 181424 None 0 Human Functional pEC50 = 6 6.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 463 10 2 5 4.6 C[C@H](C(=O)N[C@@H](C(=O)NCc1nccs1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4762642 181424 None 0 Human Functional pEC50 = 6 6.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 463 10 2 5 4.6 C[C@H](C(=O)N[C@@H](C(=O)NCc1nccs1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
118727649 117610 None 0 Human Functional pEC50 = 5 5.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2cccnc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400240 117610 None 0 Human Functional pEC50 = 5 5.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2cccnc2)cc1 10.1016/j.bmcl.2015.02.038
168279298 191156 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 433 10 2 6 3.6 C[C@H](C(=O)N[C@@H](Cn1cc(CN)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5187140 191156 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 433 10 2 6 3.6 C[C@H](C(=O)N[C@@H](Cn1cc(CN)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168279298 191156 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 433 10 2 6 3.6 C[C@H](C(=O)N[C@@H](Cn1cc(CN)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5187140 191156 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 433 10 2 6 3.6 C[C@H](C(=O)N[C@@H](Cn1cc(CN)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
118727609 117572 None 0 Human Functional pEC50 = 8.0 8.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 6 1 2 5.9 CC(C)(C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400201 117572 None 0 Human Functional pEC50 = 8.0 8.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 6 1 2 5.9 CC(C)(C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
51356430 118057 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403768 118057 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
118730001 118058 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403772 118058 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
58466401 118066 None 0 Human Functional pEC50 = 7.0 7.0 5 2
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403780 118066 None 0 Human Functional pEC50 = 7.0 7.0 5 2
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3884102 118066 None 0 Human Functional pEC50 = 7.0 7.0 5 2
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
118727684 117645 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 498 11 1 4 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CCC(=O)OC)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400275 117645 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 498 11 1 4 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CCC(=O)OC)cc2)cc1 10.1016/j.bmcl.2015.02.038
51355323 134109 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2ccccn2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716191 134109 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2ccccn2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355323 134109 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2ccccn2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716191 134109 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2ccccn2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
118727661 117622 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 COc1cccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2015.02.038
CHEMBL3400252 117622 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 COc1cccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2015.02.038
118727682 117643 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 2 3 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CO)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400273 117643 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 2 3 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CO)cc2)cc1 10.1016/j.bmcl.2015.02.038
118727633 117593 None 0 Human Functional pEC50 = 5.0 5.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1c(F)cccc1F)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400224 117593 None 0 Human Functional pEC50 = 5.0 5.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1c(F)cccc1F)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
162651180 180294 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 421 11 1 5 5.1 CCCC(C)COc1ccc([C@H](Cc2nnco2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4749371 180294 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 421 11 1 5 5.1 CCCC(C)COc1ccc([C@H](Cc2nnco2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162651180 180294 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 421 11 1 5 5.1 CCCC(C)COc1ccc([C@H](Cc2nnco2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4749371 180294 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 421 11 1 5 5.1 CCCC(C)COc1ccc([C@H](Cc2nnco2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168282483 190853 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 10 1 6 4.3 CC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5182820 190853 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 10 1 6 4.3 CC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
58466521 1064 None 6 Mouse Functional pEC50 = 5.9 5.9 -26 2
Agonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation countingAgonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation counting
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
7798 1064 None 6 Mouse Functional pEC50 = 5.9 5.9 -26 2
Agonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation countingAgonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation counting
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
CHEMBL3401461 1064 None 6 Mouse Functional pEC50 = 5.9 5.9 -26 2
Agonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation countingAgonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation counting
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
168282483 190853 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 10 1 6 4.3 CC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5182820 190853 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 10 1 6 4.3 CC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
10031 3412 None 10 Human Functional pEC50 = 6.9 6.9 2 2
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.2c01983
134813902 3412 None 10 Human Functional pEC50 = 6.9 6.9 2 2
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.2c01983
CHEMBL4595209 3412 None 10 Human Functional pEC50 = 6.9 6.9 2 2
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.2c01983
162647665 179900 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 410 11 2 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4744793 179900 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 410 11 2 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC)cc1 10.1021/acs.jmedchem.0c01581
118730004 118062 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 385 11 2 4 4.0 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](OC)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403776 118062 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 385 11 2 4 4.0 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](OC)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
118727677 117638 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(OC)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400268 117638 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(OC)cc2)cc1 10.1016/j.bmcl.2015.02.038
162647665 179900 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 410 11 2 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4744793 179900 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 410 11 2 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC)cc1 10.1021/acs.jmedchem.0c01581
118727625 117587 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 8 1 2 6.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(C)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400216 117587 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 8 1 2 6.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(C)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727651 117612 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 418 8 1 3 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccsc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400242 117612 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 418 8 1 3 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccsc2)cc1 10.1016/j.bmcl.2015.02.038
118727654 117615 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 402 8 1 2 5.8 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(C2=CCCC2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400245 117615 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 402 8 1 2 5.8 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(C2=CCCC2)cc1 10.1016/j.bmcl.2015.02.038
118727656 117617 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 416 8 1 2 6.2 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(C2=CCCCC2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400247 117617 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 416 8 1 2 6.2 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(C2=CCCCC2)cc1 10.1016/j.bmcl.2015.02.038
118727658 117619 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 8 1 2 6.2 Cc1cccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2015.02.038
CHEMBL3400249 117619 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 8 1 2 6.2 Cc1cccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2015.02.038
118727688 117649 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 505 10 2 4 5.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(NS(C)(=O)=O)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400279 117649 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 505 10 2 4 5.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(NS(C)(=O)=O)cc2)cc1 10.1016/j.bmcl.2015.02.038
118727693 117653 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 457 10 1 4 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@H]1C[C@@H]1c1ccccn1)c1ccc(-c2ccc(COC)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400284 117653 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 457 10 1 4 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@H]1C[C@@H]1c1ccccn1)c1ccc(-c2ccc(COC)cc2)cc1 10.1016/j.bmcl.2015.02.038
51348369 118078 None 1 Human Functional pEC50 = 6.9 6.9 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 373 9 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3403792 118078 None 1 Human Functional pEC50 = 6.9 6.9 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 373 9 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
51348369 118078 None 1 Human Functional pEC50 = 6.9 6.9 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 373 9 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3403792 118078 None 1 Human Functional pEC50 = 6.9 6.9 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 373 9 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
58466521 1064 None 6 Human Functional pEC50 = 6.9 6.9 26 2
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
7798 1064 None 6 Human Functional pEC50 = 6.9 6.9 26 2
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
CHEMBL3401461 1064 None 6 Human Functional pEC50 = 6.9 6.9 26 2
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
155524266 176604 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4454851 176604 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596750 176604 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
155555152 176611 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 445 9 1 5 4.3 COc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4550415 176611 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 445 9 1 5 4.3 COc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596869 176611 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 445 9 1 5 4.3 COc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
155566460 176706 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 475 9 1 3 6.5 CCCc1ccc(-c2ccc(N(C[C@@H](N)c3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4587388 176706 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 475 9 1 3 6.5 CCCc1ccc(-c2ccc(N(C[C@@H](N)c3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4597686 176706 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 475 9 1 3 6.5 CCCc1ccc(-c2ccc(N(C[C@@H](N)c3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
58466521 1064 None 6 Human Functional pEC50 = 6.9 6.9 26 2
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
7798 1064 None 6 Human Functional pEC50 = 6.9 6.9 26 2
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
CHEMBL3401461 1064 None 6 Human Functional pEC50 = 6.9 6.9 26 2
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
155524266 176604 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4454851 176604 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596750 176604 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
155555152 176611 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 445 9 1 5 4.3 COc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4550415 176611 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 445 9 1 5 4.3 COc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596869 176611 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 445 9 1 5 4.3 COc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
155566460 176706 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 475 9 1 3 6.5 CCCc1ccc(-c2ccc(N(C[C@@H](N)c3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4587388 176706 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 475 9 1 3 6.5 CCCc1ccc(-c2ccc(N(C[C@@H](N)c3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4597686 176706 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 475 9 1 3 6.5 CCCc1ccc(-c2ccc(N(C[C@@H](N)c3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
162667879 182511 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 389 8 2 3 4.1 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CC(F)(F)C2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4785604 182511 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 389 8 2 3 4.1 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CC(F)(F)C2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162667879 182511 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 389 8 2 3 4.1 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CC(F)(F)C2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4785604 182511 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 389 8 2 3 4.1 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CC(F)(F)C2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
168275346 190348 None 0 Human Functional pEC50 = 7.9 7.9 549 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 477 12 2 6 4.1 CCC[C@H](C)COc1ccc([C@H](Cn2cc(C(=O)NC)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5175064 190348 None 0 Human Functional pEC50 = 7.9 7.9 549 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 477 12 2 6 4.1 CCC[C@H](C)COc1ccc([C@H](Cn2cc(C(=O)NC)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
118727634 117594 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400225 117594 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727637 117597 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 414 8 1 4 4.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ncccn1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400228 117597 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 414 8 1 4 4.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ncccn1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727632 117592 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cc1F)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400223 117592 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cc1F)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727644 117605 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 433 8 1 4 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ncc(C)s1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400235 117605 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 433 8 1 4 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ncc(C)s1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727650 117611 None 0 Human Functional pEC50 = 4.9 4.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccncc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400241 117611 None 0 Human Functional pEC50 = 4.9 4.9 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccncc2)cc1 10.1016/j.bmcl.2015.02.038
168292704 192170 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nc(C)no2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5202571 192170 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nc(C)no2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
168292704 192170 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nc(C)no2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5202571 192170 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nc(C)no2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
86658399 142275 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 394 11 1 3 5.8 CCCC(C)COc1ccc([C@H](CN=[N+]=[N-])NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884002 142275 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 394 11 1 3 5.8 CCCC(C)COc1ccc([C@H](CN=[N+]=[N-])NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
86658399 142275 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 394 11 1 3 5.8 CCCC(C)COc1ccc([C@H](CN=[N+]=[N-])NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884002 142275 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 394 11 1 3 5.8 CCCC(C)COc1ccc([C@H](CN=[N+]=[N-])NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
162669690 183852 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 420 9 2 6 4.0 C[C@H](C(=O)N[C@@H](Cc1nnc(N)o1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4789484 183852 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 420 9 2 6 4.0 C[C@H](C(=O)N[C@@H](Cc1nnc(N)o1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4803720 183852 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 420 9 2 6 4.0 C[C@H](C(=O)N[C@@H](Cc1nnc(N)o1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162672689 183874 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4795623 183874 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4803902 183874 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162669690 183852 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 420 9 2 6 4.0 C[C@H](C(=O)N[C@@H](Cc1nnc(N)o1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4789484 183852 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 420 9 2 6 4.0 C[C@H](C(=O)N[C@@H](Cc1nnc(N)o1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4803720 183852 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 420 9 2 6 4.0 C[C@H](C(=O)N[C@@H](Cc1nnc(N)o1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162672689 183874 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4795623 183874 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4803902 183874 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168275346 190348 None 0 Human Functional pEC50 = 7.9 7.9 549 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 477 12 2 6 4.1 CCC[C@H](C)COc1ccc([C@H](Cn2cc(C(=O)NC)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5175064 190348 None 0 Human Functional pEC50 = 7.9 7.9 549 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 477 12 2 6 4.1 CCC[C@H](C)COc1ccc([C@H](Cn2cc(C(=O)NC)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
51355324 134064 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CC)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3716055 134064 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CC)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
134131592 142351 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 12 2 3 4.7 CCCC(C)COc1ccc([C@H](CO)NC(=O)CCCc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884899 142351 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 12 2 3 4.7 CCCC(C)COc1ccc([C@H](CO)NC(=O)CCCc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
134131592 142351 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 12 2 3 4.7 CCCC(C)COc1ccc([C@H](CO)NC(=O)CCCc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884899 142351 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 12 2 3 4.7 CCCC(C)COc1ccc([C@H](CO)NC(=O)CCCc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
51355324 134064 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CC)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3716055 134064 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CC)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
162656011 180874 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nnc(C)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4756228 180874 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nnc(C)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162656011 180874 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nnc(C)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL4756228 180874 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nnc(C)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
162656011 180874 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nnc(C)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4756228 180874 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nnc(C)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162656011 180874 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nnc(C)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL4756228 180874 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nnc(C)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
51348956 117764 None 0 Human Functional pEC50 = 7.8 7.8 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 457 10 1 4 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(COC)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3401459 117764 None 0 Human Functional pEC50 = 7.8 7.8 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 457 10 1 4 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(COC)cc2)cc1 10.1016/j.bmcl.2015.02.038
118730006 118064 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 398 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)N(CC)Cc2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403778 118064 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 398 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)N(CC)Cc2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
118727635 117595 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccnc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400226 117595 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccnc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727636 117596 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccncc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400227 117596 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccncc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727646 117607 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 433 8 1 4 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1csc(C)n1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400237 117607 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 433 8 1 4 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1csc(C)n1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727652 117613 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 418 8 1 3 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2cccs2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400243 117613 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 418 8 1 3 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2cccs2)cc1 10.1016/j.bmcl.2015.02.038
51356139 133826 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 451 13 3 4 4.8 CCCC(C)COc1ccc([C@H](CNC[C@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715186 133826 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 451 13 3 4 4.8 CCCC(C)COc1ccc([C@H](CNC[C@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51356139 133826 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 451 13 3 4 4.8 CCCC(C)COc1ccc([C@H](CNC[C@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715186 133826 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 451 13 3 4 4.8 CCCC(C)COc1ccc([C@H](CNC[C@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
172450375 197426 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 477 10 1 5 4.5 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cc(F)ccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5406718 197426 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 477 10 1 5 4.5 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cc(F)ccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5499131 197426 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 477 10 1 5 4.5 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cc(F)ccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
155516532 176345 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 441 9 1 3 5.8 CCCc1ccc(-c2ccc(N(C[C@@H](N)C(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4443664 176345 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 441 9 1 3 5.8 CCCc1ccc(-c2ccc(N(C[C@@H](N)C(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4594745 176345 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 441 9 1 3 5.8 CCCc1ccc(-c2ccc(N(C[C@@H](N)C(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
155516532 176345 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 441 9 1 3 5.8 CCCc1ccc(-c2ccc(N(C[C@@H](N)C(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4443664 176345 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 441 9 1 3 5.8 CCCc1ccc(-c2ccc(N(C[C@@H](N)C(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4594745 176345 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 441 9 1 3 5.8 CCCc1ccc(-c2ccc(N(C[C@@H](N)C(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
118730008 118071 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 369 9 2 3 4.4 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(C)c1 10.1016/j.bmcl.2015.01.036
CHEMBL3403785 118071 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 369 9 2 3 4.4 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(C)c1 10.1016/j.bmcl.2015.01.036
118727627 117588 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 437 8 1 3 5.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(C#N)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400218 117588 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 437 8 1 3 5.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(C#N)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727665 117626 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2F)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400256 117626 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2F)cc1 10.1016/j.bmcl.2015.02.038
168275843 190466 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 476 11 1 7 4.2 CC(=O)OCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5177010 190466 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 476 11 1 7 4.2 CC(=O)OCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168288763 191542 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 476 11 1 7 4.3 CCOC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5192946 191542 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 476 11 1 7 4.3 CCOC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168275843 190466 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 476 11 1 7 4.2 CC(=O)OCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5177010 190466 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 476 11 1 7 4.2 CC(=O)OCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168288763 191542 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 476 11 1 7 4.3 CCOC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5192946 191542 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 476 11 1 7 4.3 CCOC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
118730003 118060 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 341 9 2 3 4.0 CCCC(C)COc1ccc([C@H](CO)NC(=O)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403774 118060 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 341 9 2 3 4.0 CCCC(C)COc1ccc([C@H](CO)NC(=O)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
118730011 118074 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 383 9 2 3 4.7 CC[C@H](C)COc1cc(C)c([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(C)c1 10.1016/j.bmcl.2015.01.036
CHEMBL3403788 118074 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 383 9 2 3 4.7 CC[C@H](C)COc1cc(C)c([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(C)c1 10.1016/j.bmcl.2015.01.036
118727679 117640 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 496 9 1 3 6.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400270 117640 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 496 9 1 3 6.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1 10.1016/j.bmcl.2015.02.038
67438968 118056 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 9 2 3 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL3403767 118056 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 9 2 3 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
67438968 118056 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 9 2 3 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL3403767 118056 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 9 2 3 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168291461 191978 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 1 5 4.1 C[C@H](C(=O)N[C@@H](Cn1cncn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5199510 191978 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 1 5 4.1 C[C@H](C(=O)N[C@@H](Cn1cncn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168291461 191978 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 1 5 4.1 C[C@H](C(=O)N[C@@H](Cn1cncn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5199510 191978 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 1 5 4.1 C[C@H](C(=O)N[C@@H](Cn1cncn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
162667116 182581 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 424 11 2 3 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4786591 182581 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 424 11 2 3 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)C)cc1 10.1021/acs.jmedchem.0c01581
168274529 190371 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 480 10 1 5 5.8 C[C@H](C(=O)N[C@@H](Cn1cc(-c2ccccc2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5175440 190371 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 480 10 1 5 5.8 C[C@H](C(=O)N[C@@H](Cn1cc(-c2ccccc2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168281814 191091 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 11 1 5 5.1 CCCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5186221 191091 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 11 1 5 5.1 CCCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
162667116 182581 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 424 11 2 3 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4786591 182581 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 424 11 2 3 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)C)cc1 10.1021/acs.jmedchem.0c01581
168274529 190371 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 480 10 1 5 5.8 C[C@H](C(=O)N[C@@H](Cn1cc(-c2ccccc2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5175440 190371 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 480 10 1 5 5.8 C[C@H](C(=O)N[C@@H](Cn1cc(-c2ccccc2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168281814 191091 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 11 1 5 5.1 CCCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5186221 191091 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 11 1 5 5.1 CCCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
172451582 197433 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 464 10 1 5 5.1 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccsc3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5410885 197433 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 464 10 1 5 5.1 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccsc3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5499197 197433 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 464 10 1 5 5.1 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccsc3)cc2)cc1 10.1021/acs.jmedchem.2c01983
172468011 197550 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 477 10 1 5 4.5 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ncccc3F)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5426317 197550 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 477 10 1 5 4.5 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ncccc3F)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5500038 197550 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 477 10 1 5 4.5 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ncccc3F)cc2)cc1 10.1021/acs.jmedchem.2c01983
67438968 118056 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 355 9 2 3 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403767 118056 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 355 9 2 3 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
118730010 118073 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 385 10 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(OC)c1 10.1016/j.bmcl.2015.01.036
CHEMBL3403787 118073 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 385 10 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(OC)c1 10.1016/j.bmcl.2015.01.036
118727638 117598 None 0 Human Functional pEC50 = 4.7 4.7 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 414 8 1 4 4.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cncnc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400229 117598 None 0 Human Functional pEC50 = 4.7 4.7 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 414 8 1 4 4.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cncnc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
51356430 118057 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3403768 118057 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
51356430 118057 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL3403768 118057 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
51356430 118057 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3403768 118057 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
51356430 118057 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL3403768 118057 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168281296 190913 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 447 11 2 6 3.8 CNCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5183784 190913 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 447 11 2 6 3.8 CNCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168281296 190913 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 447 11 2 6 3.8 CNCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5183784 190913 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 447 11 2 6 3.8 CNCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
118727612 117575 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 440 10 1 2 6.6 CCC(CC)C(N)CCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400204 117575 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 440 10 1 2 6.6 CCC(CC)C(N)CCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118730165 118118 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 9 1 2 6.1 CN[C@@H](CC(C)C)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3404052 118118 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 9 1 2 6.1 CN[C@@H](CC(C)C)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
172455552 196360 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 459 9 2 5 3.9 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5422227 196360 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 459 9 2 5 3.9 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1021/acs.jmedchem.2c01983
118727616 117579 None 0 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 438 9 1 2 6.3 O=C([C@@H]1C[C@H]1c1ccccc1)N(CCNCC1CCCC1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400208 117579 None 0 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 438 9 1 2 6.3 O=C([C@@H]1C[C@H]1c1ccccc1)N(CCNCC1CCCC1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727653 117614 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 402 8 1 3 5.5 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccoc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400244 117614 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 402 8 1 3 5.5 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccoc2)cc1 10.1016/j.bmcl.2015.02.038
162660471 181453 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 12 2 3 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4763023 181453 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 12 2 3 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CC2)cc1 10.1021/acs.jmedchem.0c01581
162661701 181599 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 450 11 2 3 5.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCCC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4764798 181599 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 450 11 2 3 5.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCCC2)cc1 10.1021/acs.jmedchem.0c01581
162660471 181453 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 12 2 3 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4763023 181453 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 12 2 3 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CC2)cc1 10.1021/acs.jmedchem.0c01581
162661701 181599 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 450 11 2 3 5.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCCC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4764798 181599 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 450 11 2 3 5.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCCC2)cc1 10.1021/acs.jmedchem.0c01581
118727639 117600 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 419 8 1 4 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1nccs1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400230 117600 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 419 8 1 4 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1nccs1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727655 117616 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.5 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(C2=CCCCCC2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400246 117616 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.5 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(C2=CCCCCC2)cc1 10.1016/j.bmcl.2015.02.038
118727664 117625 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2cccc(F)c2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400255 117625 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2cccc(F)c2)cc1 10.1016/j.bmcl.2015.02.038
162654782 180693 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 452 12 2 3 5.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)C(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4754332 180693 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 452 12 2 3 5.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)C(C)C)cc1 10.1021/acs.jmedchem.0c01581
162654782 180693 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 452 12 2 3 5.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)C(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4754332 180693 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 452 12 2 3 5.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)C(C)C)cc1 10.1021/acs.jmedchem.0c01581
162657753 181132 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 472 12 2 3 5.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4759273 181132 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 472 12 2 3 5.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162657753 181132 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 472 12 2 3 5.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4759273 181132 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 472 12 2 3 5.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
118727618 117582 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 446 8 1 2 6.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(Cl)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400210 117582 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 446 8 1 2 6.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(Cl)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
172444759 197383 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 464 10 1 5 5.1 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cccs3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5395022 197383 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 464 10 1 5 5.1 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cccs3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5498820 197383 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 464 10 1 5 5.1 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cccs3)cc2)cc1 10.1021/acs.jmedchem.2c01983
118727670 117631 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400261 117631 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727647 117608 None 0 Human Functional pEC50 = 4.6 4.6 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1cccc(-c2ccccc2)c1 10.1016/j.bmcl.2015.02.038
CHEMBL3400238 117608 None 0 Human Functional pEC50 = 4.6 4.6 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1cccc(-c2ccccc2)c1 10.1016/j.bmcl.2015.02.038
162658043 181253 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 450 11 2 3 5.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2(C)CCC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4760733 181253 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 450 11 2 3 5.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2(C)CCC2)cc1 10.1021/acs.jmedchem.0c01581
162661453 181529 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 353 8 2 3 3.8 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4763920 181529 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 353 8 2 3 3.8 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162658043 181253 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 450 11 2 3 5.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2(C)CCC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4760733 181253 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 450 11 2 3 5.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2(C)CCC2)cc1 10.1021/acs.jmedchem.0c01581
162661453 181529 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 353 8 2 3 3.8 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4763920 181529 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 353 8 2 3 3.8 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
172463714 197513 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 473 10 1 5 4.7 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cccc(C)n3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5431557 197513 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 473 10 1 5 4.7 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cccc(C)n3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5499816 197513 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 473 10 1 5 4.7 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cccc(C)n3)cc2)cc1 10.1021/acs.jmedchem.2c01983
162659288 181396 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 11 2 3 4.7 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4762227 181396 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 11 2 3 4.7 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CC2)cc1 10.1021/acs.jmedchem.0c01581
172465640 197531 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 473 10 1 5 5.0 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5432580 197531 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 473 10 1 5 5.0 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5499918 197531 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 473 10 1 5 5.0 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
162659288 181396 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 11 2 3 4.7 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4762227 181396 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 11 2 3 4.7 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CC2)cc1 10.1021/acs.jmedchem.0c01581
51348522 118054 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as [35S]GTPgammaS binding after 60 mins by trilux scintillation counting analysis relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as [35S]GTPgammaS binding after 60 mins by trilux scintillation counting analysis relative to control
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403765 118054 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as [35S]GTPgammaS binding after 60 mins by trilux scintillation counting analysis relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as [35S]GTPgammaS binding after 60 mins by trilux scintillation counting analysis relative to control
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 10.1016/j.bmcl.2015.01.036
162666891 182626 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 438 12 2 3 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)CC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4787141 182626 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 438 12 2 3 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)CC)cc1 10.1021/acs.jmedchem.0c01581
162670172 182856 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 458 11 2 3 6.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)Nc2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4790074 182856 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 458 11 2 3 6.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)Nc2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168276612 190489 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 444 10 1 5 5.0 C[C@H](C(=O)N[C@@H](Cn1cc(C2CC2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5177434 190489 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 444 10 1 5 5.0 C[C@H](C(=O)N[C@@H](Cn1cc(C2CC2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
162666891 182626 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 438 12 2 3 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)CC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4787141 182626 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 438 12 2 3 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)CC)cc1 10.1021/acs.jmedchem.0c01581
162670172 182856 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 458 11 2 3 6.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)Nc2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4790074 182856 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 458 11 2 3 6.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)Nc2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168276612 190489 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 444 10 1 5 5.0 C[C@H](C(=O)N[C@@H](Cn1cc(C2CC2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5177434 190489 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 444 10 1 5 5.0 C[C@H](C(=O)N[C@@H](Cn1cc(C2CC2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
10031 3412 None 10 Human Functional pEC50 = 7.6 7.6 2 2
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
134813902 3412 None 10 Human Functional pEC50 = 7.6 7.6 2 2
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
CHEMBL4595209 3412 None 10 Human Functional pEC50 = 7.6 7.6 2 2
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
10031 3412 None 10 Mouse Functional pEC50 = 7.6 7.6 -2 2
Agonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation countingAgonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation counting
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.0c01581
134813902 3412 None 10 Mouse Functional pEC50 = 7.6 7.6 -2 2
Agonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation countingAgonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation counting
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.0c01581
CHEMBL4595209 3412 None 10 Mouse Functional pEC50 = 7.6 7.6 -2 2
Agonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation countingAgonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation counting
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.0c01581
10031 3412 None 10 Human Functional pEC50 = 7.6 7.6 2 2
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
134813902 3412 None 10 Human Functional pEC50 = 7.6 7.6 2 2
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
CHEMBL4595209 3412 None 10 Human Functional pEC50 = 7.6 7.6 2 2
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
118730018 118080 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 331 5 2 2 3.8 O=C(N[C@@H](CO)c1ccc2ccccc2c1)[C@H]1C[C@@H]1c1ccccc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403797 118080 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 331 5 2 2 3.8 O=C(N[C@@H](CO)c1ccc2ccccc2c1)[C@H]1C[C@@H]1c1ccccc1 10.1016/j.bmcl.2015.01.036
162657060 181005 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 9 2 3 4.1 CCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4757666 181005 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 9 2 3 4.1 CCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162657060 181005 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 9 2 3 4.1 CCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4757666 181005 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 9 2 3 4.1 CCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
58466412 134378 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 380 8 2 3 4.4 CC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)[C@H]2CCCN2)cc1 nan
CHEMBL3717100 134378 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 380 8 2 3 4.4 CC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)[C@H]2CCCN2)cc1 nan
58466412 134378 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 380 8 2 3 4.4 CC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)[C@H]2CCCN2)cc1 nan
CHEMBL3717100 134378 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 380 8 2 3 4.4 CC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)[C@H]2CCCN2)cc1 nan
162646899 179679 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 367 8 2 3 4.2 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CCCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4741911 179679 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 367 8 2 3 4.2 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CCCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162646899 179679 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 367 8 2 3 4.2 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CCCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4741911 179679 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 367 8 2 3 4.2 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CCCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
172465685 197532 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 459 10 1 5 4.6 CCOc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5434502 197532 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 459 10 1 5 4.6 CCOc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5499922 197532 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 459 10 1 5 4.6 CCOc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
118730012 118075 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 370 9 2 4 3.8 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(C)n1 10.1016/j.bmcl.2015.01.036
CHEMBL3403789 118075 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 370 9 2 4 3.8 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(C)n1 10.1016/j.bmcl.2015.01.036
118727685 117646 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 484 10 1 4 6.0 CCOC(=O)c1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400276 117646 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 484 10 1 4 6.0 CCOC(=O)c1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
168289890 191509 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 10 1 5 4.7 CCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5192533 191509 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 10 1 5 4.7 CCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168289890 191509 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 10 1 5 4.7 CCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5192533 191509 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 10 1 5 4.7 CCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
134131464 142381 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 10 1 4 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885190 142381 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 10 1 4 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
134131464 142381 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 10 1 4 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885190 142381 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 10 1 4 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
162643661 181796 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 12 2 4 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccco2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4776570 181796 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 12 2 4 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccco2)cc1 10.1021/acs.jmedchem.0c01581
162643661 181796 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 12 2 4 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccco2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4776570 181796 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 12 2 4 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccco2)cc1 10.1021/acs.jmedchem.0c01581
172451377 197432 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 473 10 1 5 5.0 CO[C@@H](C)c1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5407307 197432 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 473 10 1 5 5.0 CO[C@@H](C)c1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5499191 197432 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 473 10 1 5 5.0 CO[C@@H](C)c1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
51354469 118065 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 397 10 2 3 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(C)(C)O)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403779 118065 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 397 10 2 3 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(C)(C)O)cc1 10.1016/j.bmcl.2015.01.036
118727681 117642 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 498 10 1 3 7.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(COC(C)(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400272 117642 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 498 10 1 3 7.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(COC(C)(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
162661800 181560 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CC(C)CCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4764409 181560 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CC(C)CCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162674526 183544 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 3 5.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4798774 183544 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 3 5.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCC2)cc1 10.1021/acs.jmedchem.0c01581
168279345 191229 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 448 11 1 6 4.3 COCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5188019 191229 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 448 11 1 6 4.3 COCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
162661800 181560 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CC(C)CCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4764409 181560 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CC(C)CCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162674526 183544 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 3 5.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4798774 183544 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 3 5.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCC2)cc1 10.1021/acs.jmedchem.0c01581
168279345 191229 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 448 11 1 6 4.3 COCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5188019 191229 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 448 11 1 6 4.3 COCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
51355032 118067 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 396 11 1 3 5.0 CCCC(C)COc1ccc([C@H](CN(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403781 118067 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 396 11 1 3 5.0 CCCC(C)COc1ccc([C@H](CN(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
172455263 197453 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 473 10 1 5 5.0 CO[C@H](C)c1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5423825 197453 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 473 10 1 5 5.0 CO[C@H](C)c1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5499367 197453 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 473 10 1 5 5.0 CO[C@H](C)c1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
162654604 180721 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 396 10 2 3 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4754668 180721 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 396 10 2 3 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC)cc1 10.1021/acs.jmedchem.0c01581
162669183 182819 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 10 2 3 4.2 CCCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4789594 182819 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 10 2 3 4.2 CCCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162676113 183468 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 405 9 1 5 4.5 C[C@H](C(=O)N[C@@H](Cc1nnco1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4797747 183468 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 405 9 1 5 4.5 C[C@H](C(=O)N[C@@H](Cc1nnco1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162654604 180721 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 396 10 2 3 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL4754668 180721 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 396 10 2 3 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC)cc1 10.1021/acs.jmedchem.1c01075
162654604 180721 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 396 10 2 3 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4754668 180721 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 396 10 2 3 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC)cc1 10.1021/acs.jmedchem.0c01581
162669183 182819 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 10 2 3 4.2 CCCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4789594 182819 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 10 2 3 4.2 CCCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162676113 183468 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 405 9 1 5 4.5 C[C@H](C(=O)N[C@@H](Cc1nnco1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4797747 183468 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 405 9 1 5 4.5 C[C@H](C(=O)N[C@@H](Cc1nnco1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
58466521 1064 None 6 Human Functional pEC50 = 8.5 8.5 26 2
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N nan
7798 1064 None 6 Human Functional pEC50 = 8.5 8.5 26 2
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N nan
CHEMBL3401461 1064 None 6 Human Functional pEC50 = 8.5 8.5 26 2
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N nan
51348956 117764 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 457 10 1 4 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3401459 117764 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 457 10 1 4 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
51348672 117765 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 471 10 1 4 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
CHEMBL3401460 117765 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 471 10 1 4 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
58466519 134506 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 421 10 1 4 4.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(OCC2CCC2)cc1 nan
CHEMBL3717562 134506 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 421 10 1 4 4.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(OCC2CCC2)cc1 nan
51348816 135229 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3715838 135229 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3719573 135229 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
51348952 135230 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 451 8 1 3 5.6 CC#Cc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
CHEMBL3719007 135230 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 451 8 1 3 5.6 CC#Cc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
CHEMBL3719574 135230 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 451 8 1 3 5.6 CC#Cc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
58466522 135231 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 471 8 1 3 6.2 CCCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3718084 135231 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 471 8 1 3 6.2 CCCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3719575 135231 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 471 8 1 3 6.2 CCCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
58466530 135232 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 487 8 1 4 6.1 CC(C)Oc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3714801 135232 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 487 8 1 4 6.1 CC(C)Oc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3719576 135232 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 487 8 1 4 6.1 CC(C)Oc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
58466532 135233 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 473 8 1 4 5.4 COCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3718807 135233 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 473 8 1 4 5.4 COCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3719577 135233 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 473 8 1 4 5.4 COCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
58466518 135234 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 469 8 1 4 5.3 CCCc1ccc(-c2ccc(N(CC3(N)CCOCC3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
CHEMBL3716013 135234 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 469 8 1 4 5.3 CCCc1ccc(-c2ccc(N(CC3(N)CCOCC3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
CHEMBL3719578 135234 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 469 8 1 4 5.3 CCCc1ccc(-c2ccc(N(CC3(N)CCOCC3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
127024356 135235 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ncccc3F)cc2)cc1 nan
CHEMBL3718515 135235 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ncccc3F)cc2)cc1 nan
CHEMBL3719579 135235 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ncccc3F)cc2)cc1 nan
67114108 135236 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 456 10 1 4 5.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
CHEMBL3715829 135236 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 456 10 1 4 5.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
CHEMBL3719580 135236 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 456 10 1 4 5.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
58466524 135237 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3715807 135237 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3719581 135237 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
58466514 135239 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3717656 135239 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3719583 135239 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(COC)cc2)cc1 nan
58466535 135240 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 439 10 1 4 4.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(OCC2CCC2)cc1 nan
CHEMBL3716470 135240 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 439 10 1 4 4.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(OCC2CCC2)cc1 nan
CHEMBL3719584 135240 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 439 10 1 4 4.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(OCC2CCC2)cc1 nan
58466528 135241 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 458 10 1 5 4.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
CHEMBL3718875 135241 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 458 10 1 5 4.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
CHEMBL3719585 135241 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 458 10 1 5 4.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
86658431 135242 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 421 8 1 3 4.9 CCCC#Cc1ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@H]2C[C@@H]2c2cccc(F)n2)cc1 nan
CHEMBL3718945 135242 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 421 8 1 3 4.9 CCCC#Cc1ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@H]2C[C@@H]2c2cccc(F)n2)cc1 nan
CHEMBL3719586 135242 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 421 8 1 3 4.9 CCCC#Cc1ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@H]2C[C@@H]2c2cccc(F)n2)cc1 nan
51349088 135243 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 445 8 1 3 5.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc2cc(C3CC3)ccc2c1 nan
CHEMBL3718796 135243 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 445 8 1 3 5.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc2cc(C3CC3)ccc2c1 nan
CHEMBL3719587 135243 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 445 8 1 3 5.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc2cc(C3CC3)ccc2c1 nan
58466521 1064 None 6 Human Functional pEC50 = 8.5 8.5 26 2
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N nan
7798 1064 None 6 Human Functional pEC50 = 8.5 8.5 26 2
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N nan
CHEMBL3401461 1064 None 6 Human Functional pEC50 = 8.5 8.5 26 2
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N nan
51348956 117764 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 457 10 1 4 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3401459 117764 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 457 10 1 4 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
51348672 117765 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 471 10 1 4 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
CHEMBL3401460 117765 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 471 10 1 4 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
58466519 134506 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 421 10 1 4 4.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(OCC2CCC2)cc1 nan
CHEMBL3717562 134506 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 421 10 1 4 4.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(OCC2CCC2)cc1 nan
51348816 135229 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3715838 135229 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3719573 135229 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
51348952 135230 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 451 8 1 3 5.6 CC#Cc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
CHEMBL3719007 135230 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 451 8 1 3 5.6 CC#Cc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
CHEMBL3719574 135230 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 451 8 1 3 5.6 CC#Cc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
58466522 135231 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 471 8 1 3 6.2 CCCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3718084 135231 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 471 8 1 3 6.2 CCCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3719575 135231 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 471 8 1 3 6.2 CCCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
58466530 135232 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 487 8 1 4 6.1 CC(C)Oc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3714801 135232 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 487 8 1 4 6.1 CC(C)Oc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3719576 135232 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 487 8 1 4 6.1 CC(C)Oc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
58466532 135233 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 473 8 1 4 5.4 COCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3718807 135233 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 473 8 1 4 5.4 COCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3719577 135233 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 473 8 1 4 5.4 COCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
58466518 135234 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 469 8 1 4 5.3 CCCc1ccc(-c2ccc(N(CC3(N)CCOCC3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
CHEMBL3716013 135234 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 469 8 1 4 5.3 CCCc1ccc(-c2ccc(N(CC3(N)CCOCC3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
CHEMBL3719578 135234 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 469 8 1 4 5.3 CCCc1ccc(-c2ccc(N(CC3(N)CCOCC3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
127024356 135235 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ncccc3F)cc2)cc1 nan
CHEMBL3718515 135235 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ncccc3F)cc2)cc1 nan
CHEMBL3719579 135235 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ncccc3F)cc2)cc1 nan
67114108 135236 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 456 10 1 4 5.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
CHEMBL3715829 135236 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 456 10 1 4 5.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
CHEMBL3719580 135236 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 456 10 1 4 5.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
58466524 135237 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3715807 135237 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3719581 135237 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
58466514 135239 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3717656 135239 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3719583 135239 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(COC)cc2)cc1 nan
58466535 135240 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 439 10 1 4 4.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(OCC2CCC2)cc1 nan
CHEMBL3716470 135240 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 439 10 1 4 4.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(OCC2CCC2)cc1 nan
CHEMBL3719584 135240 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 439 10 1 4 4.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(OCC2CCC2)cc1 nan
58466528 135241 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 458 10 1 5 4.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
CHEMBL3718875 135241 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 458 10 1 5 4.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
CHEMBL3719585 135241 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 458 10 1 5 4.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
86658431 135242 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 421 8 1 3 4.9 CCCC#Cc1ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@H]2C[C@@H]2c2cccc(F)n2)cc1 nan
CHEMBL3718945 135242 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 421 8 1 3 4.9 CCCC#Cc1ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@H]2C[C@@H]2c2cccc(F)n2)cc1 nan
CHEMBL3719586 135242 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 421 8 1 3 4.9 CCCC#Cc1ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@H]2C[C@@H]2c2cccc(F)n2)cc1 nan
51349088 135243 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 445 8 1 3 5.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc2cc(C3CC3)ccc2c1 nan
CHEMBL3718796 135243 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 445 8 1 3 5.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc2cc(C3CC3)ccc2c1 nan
CHEMBL3719587 135243 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 445 8 1 3 5.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc2cc(C3CC3)ccc2c1 nan
118727611 117574 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 9 1 2 6.3 CC(C)C[C@H](N)CCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400203 117574 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 9 1 2 6.3 CC(C)C[C@H](N)CCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
58466521 1064 None 6 Human Functional pEC50 = 8.5 8.5 26 2
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmcl.2015.02.038
7798 1064 None 6 Human Functional pEC50 = 8.5 8.5 26 2
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmcl.2015.02.038
CHEMBL3401461 1064 None 6 Human Functional pEC50 = 8.5 8.5 26 2
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmcl.2015.02.038
51348672 117765 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 471 10 1 4 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3401460 117765 None 0 Human Functional pEC50 = 8.5 8.5 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 471 10 1 4 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
118727621 117583 None 0 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(OC)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400212 117583 None 0 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(OC)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
162665770 182448 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 367 8 2 3 4.1 CC1CC(COc2ccc([C@H](CO)NC(=O)[C@@H](C)c3ccccc3)cc2)C1 10.1021/acs.jmedchem.0c01581
CHEMBL4784512 182448 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 367 8 2 3 4.1 CC1CC(COc2ccc([C@H](CO)NC(=O)[C@@H](C)c3ccccc3)cc2)C1 10.1021/acs.jmedchem.0c01581
162665770 182448 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 367 8 2 3 4.1 CC1CC(COc2ccc([C@H](CO)NC(=O)[C@@H](C)c3ccccc3)cc2)C1 10.1021/acs.jmedchem.0c01581
CHEMBL4784512 182448 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 367 8 2 3 4.1 CC1CC(COc2ccc([C@H](CO)NC(=O)[C@@H](C)c3ccccc3)cc2)C1 10.1021/acs.jmedchem.0c01581
162674462 183438 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 438 10 2 3 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4797419 183438 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 438 10 2 3 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
155524122 176476 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 427 8 1 3 5.6 CCCc1ccc(-c2ccc(N(CC(C)(C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4453972 176476 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 427 8 1 3 5.6 CCCc1ccc(-c2ccc(N(CC(C)(C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4595791 176476 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 427 8 1 3 5.6 CCCc1ccc(-c2ccc(N(CC(C)(C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
162674462 183438 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 438 10 2 3 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4797419 183438 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 438 10 2 3 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
155524122 176476 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 427 8 1 3 5.6 CCCc1ccc(-c2ccc(N(CC(C)(C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4453972 176476 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 427 8 1 3 5.6 CCCc1ccc(-c2ccc(N(CC(C)(C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4595791 176476 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 427 8 1 3 5.6 CCCc1ccc(-c2ccc(N(CC(C)(C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
118727687 117648 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 427 8 2 3 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(N)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400278 117648 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 427 8 2 3 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(N)cc2)cc1 10.1016/j.bmcl.2015.02.038
118727662 117623 None 0 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 COc1ccccc1-c1ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]2C[C@H]2c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400253 117623 None 0 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 COc1ccccc1-c1ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]2C[C@H]2c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
168274022 190346 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 419 9 1 5 4.8 Cc1noc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)n1 10.1021/acs.jmedchem.1c01075
CHEMBL5175026 190346 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 419 9 1 5 4.8 Cc1noc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)n1 10.1021/acs.jmedchem.1c01075
168274022 190346 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 419 9 1 5 4.8 Cc1noc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)n1 10.1021/acs.jmedchem.1c01075
CHEMBL5175026 190346 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 419 9 1 5 4.8 Cc1noc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)n1 10.1021/acs.jmedchem.1c01075
118727660 117621 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 COc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400251 117621 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 COc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
168279556 190968 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 486 10 1 5 6.2 C[C@H](C(=O)N[C@@H](Cn1cc(C2CCCCC2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5184589 190968 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 486 10 1 5 6.2 C[C@H](C(=O)N[C@@H](Cn1cc(C2CCCCC2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
162661550 181509 None 0 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 465 12 3 4 4.3 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CCCN2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4763624 181509 None 0 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 465 12 3 4 4.3 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CCCN2)cc1 10.1021/acs.jmedchem.0c01581
162661550 181509 None 0 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 465 12 3 4 4.3 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CCCN2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4763624 181509 None 0 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 465 12 3 4 4.3 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CCCN2)cc1 10.1021/acs.jmedchem.0c01581
168279556 190968 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 486 10 1 5 6.2 C[C@H](C(=O)N[C@@H](Cn1cc(C2CCCCC2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5184589 190968 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 486 10 1 5 6.2 C[C@H](C(=O)N[C@@H](Cn1cc(C2CCCCC2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
118727674 117635 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 480 8 1 2 6.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400265 117635 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 480 8 1 2 6.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1 10.1016/j.bmcl.2015.02.038
118727659 117620 None 0 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 8 1 2 6.2 Cc1ccccc1-c1ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]2C[C@H]2c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400250 117620 None 0 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 8 1 2 6.2 Cc1ccccc1-c1ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]2C[C@H]2c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
134130396 142307 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 369 11 2 3 4.3 CCCC(C)COc1ccc([C@H](CO)NC(=O)CCc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884316 142307 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 369 11 2 3 4.3 CCCC(C)COc1ccc([C@H](CO)NC(=O)CCc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
134130396 142307 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 369 11 2 3 4.3 CCCC(C)COc1ccc([C@H](CO)NC(=O)CCc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884316 142307 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 369 11 2 3 4.3 CCCC(C)COc1ccc([C@H](CO)NC(=O)CCc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
118727680 117641 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 456 10 1 3 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(COC)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400271 117641 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 456 10 1 3 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(COC)cc2)cc1 10.1016/j.bmcl.2015.02.038
168282137 190919 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 2 4 4.2 C[C@H](C(=O)N[C@@H](Cc1c[nH]nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5183838 190919 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 2 4 4.2 C[C@H](C(=O)N[C@@H](Cc1c[nH]nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168282137 190919 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 2 4 4.2 C[C@H](C(=O)N[C@@H](Cc1c[nH]nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5183838 190919 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 2 4 4.2 C[C@H](C(=O)N[C@@H](Cc1c[nH]nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
172441777 197364 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 485 9 1 5 5.1 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc([C@H]3CCCO3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5402674 197364 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 485 9 1 5 5.1 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc([C@H]3CCCO3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5498679 197364 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 485 9 1 5 5.1 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc([C@H]3CCCO3)cc2)cc1 10.1021/acs.jmedchem.2c01983
118727640 117601 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 418 8 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccs1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400231 117601 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 418 8 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccs1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727657 117618 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 8 1 2 6.2 Cc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400248 117618 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 8 1 2 6.2 Cc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
118727645 117606 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 447 8 1 4 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1nc(C)c(C)s1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400236 117606 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 447 8 1 4 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1nc(C)c(C)s1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
168277341 190407 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 10 1 5 5.2 CC(C)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5175963 190407 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 10 1 5 5.2 CC(C)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168277341 190407 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 10 1 5 5.2 CC(C)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5175963 190407 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 10 1 5 5.2 CC(C)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
162651966 180297 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 446 10 3 4 3.9 C[C@H](C(=O)N[C@@H](C(=O)NCc1ncc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4749480 180297 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 446 10 3 4 3.9 C[C@H](C(=O)N[C@@H](C(=O)NCc1ncc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162651966 180297 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 446 10 3 4 3.9 C[C@H](C(=O)N[C@@H](C(=O)NCc1ncc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4749480 180297 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 446 10 3 4 3.9 C[C@H](C(=O)N[C@@H](C(=O)NCc1ncc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
134131577 142327 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 397 10 1 4 4.4 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(C)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884700 142327 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 397 10 1 4 4.4 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(C)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
162677103 183633 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 419 9 1 5 4.8 Cc1nnc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
CHEMBL4799883 183633 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 419 9 1 5 4.8 Cc1nnc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
168275929 190689 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 1 5 4.2 C[C@H](C(=O)N[C@@H](Cc1cnn(C)n1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5180324 190689 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 1 5 4.2 C[C@H](C(=O)N[C@@H](Cc1cnn(C)n1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
134131577 142327 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 397 10 1 4 4.4 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(C)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884700 142327 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 397 10 1 4 4.4 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(C)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
162677103 183633 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 419 9 1 5 4.8 Cc1nnc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
CHEMBL4799883 183633 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 419 9 1 5 4.8 Cc1nnc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
168275929 190689 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 1 5 4.2 C[C@H](C(=O)N[C@@H](Cc1cnn(C)n1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5180324 190689 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 1 5 4.2 C[C@H](C(=O)N[C@@H](Cc1cnn(C)n1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
162658387 181142 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.6 CCCCC(C)Oc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4759345 181142 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.6 CCCCC(C)Oc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162643654 181776 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 341 9 2 3 3.8 CCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4776381 181776 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 341 9 2 3 3.8 CCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162658387 181142 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.6 CCCCC(C)Oc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4759345 181142 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.6 CCCCC(C)Oc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162643654 181776 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 341 9 2 3 3.8 CCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4776381 181776 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 341 9 2 3 3.8 CCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
118727669 117630 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 446 8 1 2 6.5 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2Cl)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400260 117630 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 446 8 1 2 6.5 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2Cl)cc1 10.1016/j.bmcl.2015.02.038
168287256 191918 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 475 10 1 6 3.8 C[C@H](C(=O)N[C@@H](Cn1cc(C(=O)N(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5198398 191918 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 475 10 1 6 3.8 C[C@H](C(=O)N[C@@H](Cn1cc(C(=O)N(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168287256 191918 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 475 10 1 6 3.8 C[C@H](C(=O)N[C@@H](Cn1cc(C(=O)N(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5198398 191918 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 475 10 1 6 3.8 C[C@H](C(=O)N[C@@H](Cn1cc(C(=O)N(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
134130479 142413 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2cccc(F)c2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885494 142413 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2cccc(F)c2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
172445555 197393 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 477 10 1 5 4.5 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5404152 197393 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 477 10 1 5 4.5 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5498870 197393 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 477 10 1 5 4.5 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 10.1021/acs.jmedchem.2c01983
51354469 118065 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 397 10 2 3 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(C)(C)O)cc1 nan
CHEMBL3403779 118065 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 397 10 2 3 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(C)(C)O)cc1 nan
51355032 118067 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 396 11 1 3 5.0 CCCC(C)COc1ccc([C@H](CN(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403781 118067 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 396 11 1 3 5.0 CCCC(C)COc1ccc([C@H](CN(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354470 118079 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 354 9 2 3 4.0 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403793 118079 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 354 9 2 3 4.0 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355031 133777 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 453 13 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715029 133777 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 453 13 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354737 134007 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 422 13 2 3 5.5 CCCC(C)COc1ccc([C@H](CNCC2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715862 134007 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 422 13 2 3 5.5 CCCC(C)COc1ccc([C@H](CNCC2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354739 134065 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)CC(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716058 134065 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)CC(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355033 134073 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 467 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CCC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716078 134073 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 467 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CCC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355030 134163 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 467 13 3 4 4.6 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)C(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716360 134163 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 467 13 3 4 4.6 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)C(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354738 134432 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717315 134432 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355028 134662 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)[C@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3718100 134662 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)[C@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354736 134731 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 465 13 3 4 5.3 CCCC(C)COc1ccc([C@H](CNCC2(N)CCCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3718302 134731 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 465 13 3 4 5.3 CCCC(C)COc1ccc([C@H](CNCC2(N)CCCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355029 134787 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 439 12 3 4 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3718503 134787 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 439 12 3 4 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354469 118065 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 397 10 2 3 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(C)(C)O)cc1 nan
CHEMBL3403779 118065 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 397 10 2 3 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(C)(C)O)cc1 nan
51355032 118067 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 396 11 1 3 5.0 CCCC(C)COc1ccc([C@H](CN(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403781 118067 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 396 11 1 3 5.0 CCCC(C)COc1ccc([C@H](CN(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354470 118079 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 354 9 2 3 4.0 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403793 118079 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 354 9 2 3 4.0 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355031 133777 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 453 13 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715029 133777 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 453 13 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354737 134007 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 422 13 2 3 5.5 CCCC(C)COc1ccc([C@H](CNCC2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715862 134007 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 422 13 2 3 5.5 CCCC(C)COc1ccc([C@H](CNCC2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354739 134065 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)CC(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716058 134065 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)CC(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355033 134073 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 467 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CCC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716078 134073 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 467 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CCC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355030 134163 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 467 13 3 4 4.6 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)C(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716360 134163 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 467 13 3 4 4.6 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)C(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354738 134432 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717315 134432 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355028 134662 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)[C@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3718100 134662 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)[C@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354736 134731 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 465 13 3 4 5.3 CCCC(C)COc1ccc([C@H](CNCC2(N)CCCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3718302 134731 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 465 13 3 4 5.3 CCCC(C)COc1ccc([C@H](CNCC2(N)CCCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355029 134787 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 439 12 3 4 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3718503 134787 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 439 12 3 4 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
168293070 192211 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 461 10 2 6 3.5 CNC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5203114 192211 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 461 10 2 6 3.5 CNC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
134130479 142413 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2cccc(F)c2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885494 142413 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2cccc(F)c2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
162656522 181031 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 424 12 2 3 5.0 CCCNC(=O)[C@H](NC(=O)[C@@H](C)c1ccccc1)c1ccc(OCC(C)CCC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4758007 181031 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 424 12 2 3 5.0 CCCNC(=O)[C@H](NC(=O)[C@@H](C)c1ccccc1)c1ccc(OCC(C)CCC)cc1 10.1021/acs.jmedchem.0c01581
155524318 176542 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 413 8 1 3 5.2 CCCc1ccc(-c2ccc(N(C[C@H](C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4454531 176542 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 413 8 1 3 5.2 CCCc1ccc(-c2ccc(N(C[C@H](C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596277 176542 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 413 8 1 3 5.2 CCCc1ccc(-c2ccc(N(C[C@H](C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
162656522 181031 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 424 12 2 3 5.0 CCCNC(=O)[C@H](NC(=O)[C@@H](C)c1ccccc1)c1ccc(OCC(C)CCC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4758007 181031 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 424 12 2 3 5.0 CCCNC(=O)[C@H](NC(=O)[C@@H](C)c1ccccc1)c1ccc(OCC(C)CCC)cc1 10.1021/acs.jmedchem.0c01581
155524318 176542 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 413 8 1 3 5.2 CCCc1ccc(-c2ccc(N(C[C@H](C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4454531 176542 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 413 8 1 3 5.2 CCCc1ccc(-c2ccc(N(C[C@H](C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596277 176542 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 413 8 1 3 5.2 CCCc1ccc(-c2ccc(N(C[C@H](C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
118727604 117567 None 0 Human Functional pEC50 = 8.3 8.3 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 432 7 1 2 6.2 N[C@H](CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1)c1ccccc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400196 117567 None 0 Human Functional pEC50 = 8.3 8.3 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 432 7 1 2 6.2 N[C@H](CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1)c1ccccc1 10.1016/j.bmcl.2015.02.038
118727614 117577 None 0 Human Functional pEC50 = 8.3 8.3 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 10 1 2 6.1 CCC(C)CNCCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400206 117577 None 0 Human Functional pEC50 = 8.3 8.3 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 10 1 2 6.1 CCC(C)CNCCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
168293070 192211 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 461 10 2 6 3.5 CNC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5203114 192211 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 461 10 2 6 3.5 CNC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168294517 192339 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 448 11 1 6 4.5 CCOc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5205098 192339 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 448 11 1 6 4.5 CCOc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168294517 192339 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 448 11 1 6 4.5 CCOc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5205098 192339 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 448 11 1 6 4.5 CCOc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
118730013 118076 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 299 6 2 3 2.6 COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403790 118076 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 299 6 2 3 2.6 COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
58466401 118066 None 0 Human Functional pEC50 = 6.4 6.4 5 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL3403780 118066 None 0 Human Functional pEC50 = 6.4 6.4 5 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL3884102 118066 None 0 Human Functional pEC50 = 6.4 6.4 5 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
58466401 118066 None 0 Human Functional pEC50 = 6.4 6.4 5 2
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3403780 118066 None 0 Human Functional pEC50 = 6.4 6.4 5 2
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884102 118066 None 0 Human Functional pEC50 = 6.4 6.4 5 2
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
58466401 118066 None 0 Human Functional pEC50 = 6.4 6.4 5 2
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3403780 118066 None 0 Human Functional pEC50 = 6.4 6.4 5 2
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884102 118066 None 0 Human Functional pEC50 = 6.4 6.4 5 2
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
162661210 181582 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 426 12 3 4 3.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCO)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4764623 181582 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 426 12 3 4 3.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCO)cc1 10.1021/acs.jmedchem.0c01581
162661210 181582 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 426 12 3 4 3.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCO)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4764623 181582 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 426 12 3 4 3.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCO)cc1 10.1021/acs.jmedchem.0c01581
118727617 117580 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 446 8 1 2 6.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(Cl)cc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400209 117580 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 446 8 1 2 6.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(Cl)cc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727671 117632 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 440 9 1 2 6.4 CCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400262 117632 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 440 9 1 2 6.4 CCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
172461693 197499 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 485 9 1 5 5.1 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc([C@@H]3CCCO3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5428649 197499 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 485 9 1 5 5.1 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc([C@@H]3CCCO3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5499707 197499 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 485 9 1 5 5.1 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc([C@@H]3CCCO3)cc2)cc1 10.1021/acs.jmedchem.2c01983
10031 3412 None 10 Human Functional pEC50 = 7.4 7.4 2 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.1c01075
134813902 3412 None 10 Human Functional pEC50 = 7.4 7.4 2 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.1c01075
CHEMBL4595209 3412 None 10 Human Functional pEC50 = 7.4 7.4 2 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.1c01075
172443317 197369 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cccnc3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5398921 197369 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cccnc3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5498740 197369 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cccnc3)cc2)cc1 10.1021/acs.jmedchem.2c01983
10031 3412 None 10 Human Functional pEC50 = 7.4 7.4 2 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.1c01075
134813902 3412 None 10 Human Functional pEC50 = 7.4 7.4 2 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.1c01075
CHEMBL4595209 3412 None 10 Human Functional pEC50 = 7.4 7.4 2 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.1c01075
10031 3412 None 10 Human Functional pEC50 = 7.4 7.4 2 2
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.2c01983
134813902 3412 None 10 Human Functional pEC50 = 7.4 7.4 2 2
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.2c01983
CHEMBL4595209 3412 None 10 Human Functional pEC50 = 7.4 7.4 2 2
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.2c01983
172446049 197399 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 471 10 1 5 4.8 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC3CC3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5403253 197399 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 471 10 1 5 4.8 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC3CC3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5498907 197399 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 471 10 1 5 4.8 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC3CC3)cc2)cc1 10.1021/acs.jmedchem.2c01983
118727641 117602 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 418 8 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccsc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400232 117602 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 418 8 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccsc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727667 117628 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 437 8 1 3 5.7 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2cccc(C#N)c2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400258 117628 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 437 8 1 3 5.7 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2cccc(C#N)c2)cc1 10.1016/j.bmcl.2015.02.038
162645574 179811 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 445 10 3 3 4.5 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4743847 179811 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 445 10 3 3 4.5 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
168271605 190354 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 9 1 5 4.7 Cc1nnn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)c1C 10.1021/acs.jmedchem.1c01075
CHEMBL5175154 190354 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 9 1 5 4.7 Cc1nnn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)c1C 10.1021/acs.jmedchem.1c01075
162645574 179811 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 445 10 3 3 4.5 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4743847 179811 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 445 10 3 3 4.5 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
168271605 190354 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 9 1 5 4.7 Cc1nnn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)c1C 10.1021/acs.jmedchem.1c01075
CHEMBL5175154 190354 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 9 1 5 4.7 Cc1nnn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)c1C 10.1021/acs.jmedchem.1c01075
10031 3412 None 10 Human Functional pEC50 = 7.3 7.3 2 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.0c01581
134813902 3412 None 10 Human Functional pEC50 = 7.3 7.3 2 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.0c01581
CHEMBL4595209 3412 None 10 Human Functional pEC50 = 7.3 7.3 2 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.0c01581
118730009 118072 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 373 9 2 3 4.2 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.036
CHEMBL3403786 118072 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 373 9 2 3 4.2 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.036
118727690 117651 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 469 10 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CN(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400281 117651 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 469 10 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CN(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
162671884 182951 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 466 12 2 4 4.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CCCO2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4791411 182951 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 466 12 2 4 4.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CCCO2)cc1 10.1021/acs.jmedchem.0c01581
162676440 183588 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 454 12 2 5 3.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC(=O)OC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4799403 183588 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 454 12 2 5 3.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC(=O)OC)cc1 10.1021/acs.jmedchem.0c01581
162665250 182244 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 371 11 2 4 3.4 COCCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4782249 182244 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 371 11 2 4 3.4 COCCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162665250 182244 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 371 11 2 4 3.4 COCCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4782249 182244 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 371 11 2 4 3.4 COCCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162671884 182951 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 466 12 2 4 4.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CCCO2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4791411 182951 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 466 12 2 4 4.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CCCO2)cc1 10.1021/acs.jmedchem.0c01581
162676440 183588 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 454 12 2 5 3.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC(=O)OC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4799403 183588 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 454 12 2 5 3.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC(=O)OC)cc1 10.1021/acs.jmedchem.0c01581
10031 3412 None 10 Human Functional pEC50 = 7.3 7.3 2 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.0c01581
134813902 3412 None 10 Human Functional pEC50 = 7.3 7.3 2 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.0c01581
CHEMBL4595209 3412 None 10 Human Functional pEC50 = 7.3 7.3 2 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.0c01581
162660648 181385 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 391 8 1 5 4.3 C[C@H](C(=O)N[C@H](c1ccc(OCC2CCC2)cc1)c1nnco1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4762163 181385 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 391 8 1 5 4.3 C[C@H](C(=O)N[C@H](c1ccc(OCC2CCC2)cc1)c1nnco1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162660648 181385 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 391 8 1 5 4.3 C[C@H](C(=O)N[C@H](c1ccc(OCC2CCC2)cc1)c1nnco1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4762163 181385 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 391 8 1 5 4.3 C[C@H](C(=O)N[C@H](c1ccc(OCC2CCC2)cc1)c1nnco1)c1ccccc1 10.1021/acs.jmedchem.0c01581
168274798 190200 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 450 12 2 6 4.2 CCC[C@H](C)COc1ccc([C@H](Cn2cc(CO)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5172809 190200 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 450 12 2 6 4.2 CCC[C@H](C)COc1ccc([C@H](Cn2cc(CO)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
69925894 118061 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 355 10 2 3 3.9 CCCC(C)COc1ccc([C@H](CO)NC(=O)Cc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3403775 118061 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 355 10 2 3 3.9 CCCC(C)COc1ccc([C@H](CO)NC(=O)Cc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
69925894 118061 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 355 10 2 3 3.9 CCCC(C)COc1ccc([C@H](CO)NC(=O)Cc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3403775 118061 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 355 10 2 3 3.9 CCCC(C)COc1ccc([C@H](CO)NC(=O)Cc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
162654926 180683 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 10 2 6 3.8 Cc1nnc(CNC(=O)[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
CHEMBL4754124 180683 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 10 2 6 3.8 Cc1nnc(CNC(=O)[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
162654926 180683 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 10 2 6 3.8 Cc1nnc(CNC(=O)[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
CHEMBL4754124 180683 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 10 2 6 3.8 Cc1nnc(CNC(=O)[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
118727613 117576 None 0 Human Functional pEC50 = 8.3 8.3 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 10 1 2 6.1 CC(C)CCNCCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400205 117576 None 0 Human Functional pEC50 = 8.3 8.3 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 10 1 2 6.1 CC(C)CCNCCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118730166 118119 None 0 Human Functional pEC50 = 8.2 8.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 454 9 1 2 6.0 CC[C@H](C)[C@@H](CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1)NC(C)=O 10.1016/j.bmcl.2015.02.038
CHEMBL3404053 118119 None 0 Human Functional pEC50 = 8.2 8.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 454 9 1 2 6.0 CC[C@H](C)[C@@H](CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1)NC(C)=O 10.1016/j.bmcl.2015.02.038
58466521 1064 None 6 Human Functional pEC50 = 7.3 7.3 26 2
Agonist activity at human PPLS-HA-tagged-GPR88 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET based LANCE assayAgonist activity at human PPLS-HA-tagged-GPR88 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET based LANCE assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmc.2016.11.058
7798 1064 None 6 Human Functional pEC50 = 7.3 7.3 26 2
Agonist activity at human PPLS-HA-tagged-GPR88 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET based LANCE assayAgonist activity at human PPLS-HA-tagged-GPR88 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET based LANCE assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmc.2016.11.058
CHEMBL3401461 1064 None 6 Human Functional pEC50 = 7.3 7.3 26 2
Agonist activity at human PPLS-HA-tagged-GPR88 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET based LANCE assayAgonist activity at human PPLS-HA-tagged-GPR88 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET based LANCE assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmc.2016.11.058
118729997 118055 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 341 8 2 3 3.7 CC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403766 118055 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 341 8 2 3 3.7 CC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
168269611 190122 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 2 4 4.5 Cc1nnc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)[nH]1 10.1021/acs.jmedchem.1c01075
CHEMBL5171511 190122 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 2 4 4.5 Cc1nnc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)[nH]1 10.1021/acs.jmedchem.1c01075
155530523 176424 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 399 8 1 3 4.8 CCCc1ccc(-c2ccc(N(CCN)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4464331 176424 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 399 8 1 3 4.8 CCCc1ccc(-c2ccc(N(CCN)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4595321 176424 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 399 8 1 3 4.8 CCCc1ccc(-c2ccc(N(CCN)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
155538984 176609 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 489 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)Cc3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4513479 176609 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 489 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)Cc3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596842 176609 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 489 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)Cc3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
168269611 190122 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 2 4 4.5 Cc1nnc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)[nH]1 10.1021/acs.jmedchem.1c01075
CHEMBL5171511 190122 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 2 4 4.5 Cc1nnc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)[nH]1 10.1021/acs.jmedchem.1c01075
155530523 176424 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 399 8 1 3 4.8 CCCc1ccc(-c2ccc(N(CCN)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4464331 176424 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 399 8 1 3 4.8 CCCc1ccc(-c2ccc(N(CCN)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4595321 176424 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 399 8 1 3 4.8 CCCc1ccc(-c2ccc(N(CCN)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
155538984 176609 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 489 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)Cc3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4513479 176609 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 489 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)Cc3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596842 176609 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 489 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)Cc3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
162652578 180560 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 539 13 2 5 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN(C)C(=O)OC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4752733 180560 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 539 13 2 5 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN(C)C(=O)OC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
162644183 181905 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 447 10 3 5 3.3 C[C@H](C(=O)N[C@@H](C(=O)NCc1nnc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4778038 181905 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 447 10 3 5 3.3 C[C@H](C(=O)N[C@@H](C(=O)NCc1nnc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162644183 181905 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 447 10 3 5 3.3 C[C@H](C(=O)N[C@@H](C(=O)NCc1nnc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4778038 181905 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 447 10 3 5 3.3 C[C@H](C(=O)N[C@@H](C(=O)NCc1nnc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162652578 180560 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 539 13 2 5 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN(C)C(=O)OC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4752733 180560 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 539 13 2 5 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN(C)C(=O)OC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
172470258 197566 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 477 10 1 5 4.5 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccc(F)cn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5438959 197566 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 477 10 1 5 4.5 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccc(F)cn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5500176 197566 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 477 10 1 5 4.5 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccc(F)cn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
162664171 182274 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 421 10 1 5 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnc(C)o2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4782571 182274 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 421 10 1 5 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnc(C)o2)cc1 10.1021/acs.jmedchem.0c01581
162664171 182274 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 421 10 1 5 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnc(C)o2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4782571 182274 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 421 10 1 5 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnc(C)o2)cc1 10.1021/acs.jmedchem.0c01581
162664171 182274 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 421 10 1 5 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnc(C)o2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL4782571 182274 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 421 10 1 5 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnc(C)o2)cc1 10.1021/acs.jmedchem.1c01075
10031 3412 None 10 Mouse Functional pEC50 = 6.3 6.3 -2 2
Agonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation countingAgonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation counting
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
134813902 3412 None 10 Mouse Functional pEC50 = 6.3 6.3 -2 2
Agonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation countingAgonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation counting
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
CHEMBL4595209 3412 None 10 Mouse Functional pEC50 = 6.3 6.3 -2 2
Agonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation countingAgonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation counting
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
172454319 197445 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 460 10 1 6 3.8 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ncccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5416790 197445 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 460 10 1 6 3.8 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ncccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5499319 197445 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 460 10 1 6 3.8 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ncccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
162663886 182111 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 440 13 2 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCOC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4780568 182111 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 440 13 2 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCOC)cc1 10.1021/acs.jmedchem.0c01581
162668147 182656 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 407 10 1 5 4.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnco2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4787512 182656 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 407 10 1 5 4.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnco2)cc1 10.1021/acs.jmedchem.0c01581
162663886 182111 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 440 13 2 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCOC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4780568 182111 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 440 13 2 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCOC)cc1 10.1021/acs.jmedchem.0c01581
162668147 182656 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 407 10 1 5 4.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnco2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4787512 182656 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 407 10 1 5 4.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnco2)cc1 10.1021/acs.jmedchem.0c01581
134130337 142213 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 397 10 1 4 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3883403 142213 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 397 10 1 4 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
134130337 142213 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 397 10 1 4 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3883403 142213 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 397 10 1 4 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
58466401 118066 None 0 Human Functional pEC50 = 7.3 7.3 5 2
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403780 118066 None 0 Human Functional pEC50 = 7.3 7.3 5 2
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3884102 118066 None 0 Human Functional pEC50 = 7.3 7.3 5 2
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
58466401 118066 None 0 Human Functional pEC50 = 7.3 7.3 5 2
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403780 118066 None 0 Human Functional pEC50 = 7.3 7.3 5 2
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3884102 118066 None 0 Human Functional pEC50 = 7.3 7.3 5 2
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
172458376 197469 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 491 10 1 5 5.2 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5417765 197469 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 491 10 1 5 5.2 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5499523 197469 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 491 10 1 5 5.2 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
162651096 180339 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 446 10 2 4 4.7 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccco1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4750015 180339 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 446 10 2 4 4.7 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccco1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162653235 180555 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 405 8 1 5 4.6 Cc1nnc([C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
CHEMBL4752677 180555 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 405 8 1 5 4.6 Cc1nnc([C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
162644207 181919 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 439 13 3 4 3.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCNC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4778149 181919 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 439 13 3 4 3.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCNC)cc1 10.1021/acs.jmedchem.0c01581
162660875 181990 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 453 13 2 4 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4779002 181990 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 453 13 2 4 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN(C)C)cc1 10.1021/acs.jmedchem.0c01581
162644207 181919 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 439 13 3 4 3.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCNC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4778149 181919 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 439 13 3 4 3.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCNC)cc1 10.1021/acs.jmedchem.0c01581
162660875 181990 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 453 13 2 4 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4779002 181990 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 453 13 2 4 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN(C)C)cc1 10.1021/acs.jmedchem.0c01581
162651096 180339 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 446 10 2 4 4.7 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccco1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4750015 180339 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 446 10 2 4 4.7 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccco1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162653235 180555 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 405 8 1 5 4.6 Cc1nnc([C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
CHEMBL4752677 180555 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 405 8 1 5 4.6 Cc1nnc([C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
118727689 117650 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 469 9 2 3 5.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(NC(C)=O)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400280 117650 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 469 9 2 3 5.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(NC(C)=O)cc2)cc1 10.1016/j.bmcl.2015.02.038
58466521 1064 None 6 Human Functional pEC50 = 7.3 7.3 26 2
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
7798 1064 None 6 Human Functional pEC50 = 7.3 7.3 26 2
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
CHEMBL3401461 1064 None 6 Human Functional pEC50 = 7.3 7.3 26 2
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
118727623 117585 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400214 117585 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
162651638 180283 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 327 8 2 3 3.4 CCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4749174 180283 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 327 8 2 3 3.4 CCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162662433 182080 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 464 11 2 3 5.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCCCC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4780227 182080 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 464 11 2 3 5.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCCCC2)cc1 10.1021/acs.jmedchem.0c01581
162651638 180283 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 327 8 2 3 3.4 CCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4749174 180283 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 327 8 2 3 3.4 CCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162662433 182080 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 464 11 2 3 5.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCCCC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4780227 182080 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 464 11 2 3 5.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCCCC2)cc1 10.1021/acs.jmedchem.0c01581
118730007 118070 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 422 11 1 3 5.6 CCCC(C)COc1ccc([C@H](CN2CCCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403784 118070 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 422 11 1 3 5.6 CCCC(C)COc1ccc([C@H](CN2CCCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
162660464 181452 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 382 10 2 3 3.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(N)=O)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4763017 181452 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 382 10 2 3 3.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(N)=O)cc1 10.1021/acs.jmedchem.0c01581
162660464 181452 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 382 10 2 3 3.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(N)=O)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4763017 181452 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 382 10 2 3 3.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(N)=O)cc1 10.1021/acs.jmedchem.0c01581
162665470 182904 None 0 Human Functional pEC50 = 7.2 7.2 15 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4784623 182904 None 0 Human Functional pEC50 = 7.2 7.2 15 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4790638 182904 None 0 Human Functional pEC50 = 7.2 7.2 15 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
118727642 117603 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 402 8 1 3 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccoc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400233 117603 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 402 8 1 3 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccoc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
134129964 142373 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 411 11 1 4 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](CC)c2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885146 142373 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 411 11 1 4 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](CC)c2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
134130956 142333 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(F)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884736 142333 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(F)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
162677099 183631 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2cccnc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4799879 183631 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2cccnc2)cc1 10.1021/acs.jmedchem.0c01581
134129964 142373 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 411 11 1 4 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](CC)c2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885146 142373 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 411 11 1 4 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](CC)c2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
162667290 182660 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 357 10 2 4 3.1 COCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4787574 182660 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 357 10 2 4 3.1 COCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162667290 182660 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 357 10 2 4 3.1 COCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4787574 182660 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 357 10 2 4 3.1 COCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
134130956 142333 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(F)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884736 142333 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(F)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
162677099 183631 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2cccnc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4799879 183631 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2cccnc2)cc1 10.1021/acs.jmedchem.0c01581
162665470 182904 None 0 Human Functional pEC50 = 7.2 7.2 15 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4784623 182904 None 0 Human Functional pEC50 = 7.2 7.2 15 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4790638 182904 None 0 Human Functional pEC50 = 7.2 7.2 15 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162665470 182904 None 0 Human Functional pEC50 = 7.2 7.2 15 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL4784623 182904 None 0 Human Functional pEC50 = 7.2 7.2 15 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL4790638 182904 None 0 Human Functional pEC50 = 7.2 7.2 15 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
118727615 117578 None 0 Human Functional pEC50 = 8.2 8.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 452 9 1 2 6.7 O=C([C@@H]1C[C@H]1c1ccccc1)N(CCNCC1CCCCC1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400207 117578 None 0 Human Functional pEC50 = 8.2 8.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 452 9 1 2 6.7 O=C([C@@H]1C[C@H]1c1ccccc1)N(CCNCC1CCCCC1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
168283746 190935 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 420 11 1 5 4.8 CCCC(C)COc1ccc([C@H](Cn2ccnn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5184001 190935 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 420 11 1 5 4.8 CCCC(C)COc1ccc([C@H](Cn2ccnn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
168283746 190935 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 420 11 1 5 4.8 CCCC(C)COc1ccc([C@H](Cn2ccnn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5184001 190935 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 420 11 1 5 4.8 CCCC(C)COc1ccc([C@H](Cn2ccnn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
118727622 117584 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400213 117584 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118729996 118053 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 331 5 2 2 3.8 O=C(NC(CO)c1ccc2ccccc2c1)[C@@H]1C[C@H]1c1ccccc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403764 118053 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 331 5 2 2 3.8 O=C(NC(CO)c1ccc2ccccc2c1)[C@@H]1C[C@H]1c1ccccc1 10.1016/j.bmcl.2015.01.036
168292918 192208 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 460 9 1 5 5.4 C[C@H](C(=O)N[C@@H](Cn1cc(C(C)(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5203098 192208 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 460 9 1 5 5.4 C[C@H](C(=O)N[C@@H](Cn1cc(C(C)(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168292918 192208 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 460 9 1 5 5.4 C[C@H](C(=O)N[C@@H](Cn1cc(C(C)(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5203098 192208 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 460 9 1 5 5.4 C[C@H](C(=O)N[C@@H](Cn1cc(C(C)(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
118727672 117633 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 454 10 1 2 6.8 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400263 117633 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 454 10 1 2 6.8 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
134130466 142404 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 410 10 1 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)N(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL3885410 142404 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 410 10 1 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)N(C)C)cc1 10.1021/acs.jmedchem.0c01581
134130466 142404 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 410 10 1 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)N(C)C)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885410 142404 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 410 10 1 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)N(C)C)cc1 10.1016/j.bmc.2016.11.058
134130466 142404 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 410 10 1 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)N(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL3885410 142404 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 410 10 1 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)N(C)C)cc1 10.1021/acs.jmedchem.0c01581
162646652 179588 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccccn2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4740926 179588 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccccn2)cc1 10.1021/acs.jmedchem.0c01581
134130466 142404 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 410 10 1 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)N(C)C)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885410 142404 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 410 10 1 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)N(C)C)cc1 10.1016/j.bmc.2016.11.058
162646652 179588 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccccn2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4740926 179588 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccccn2)cc1 10.1021/acs.jmedchem.0c01581
51348522 118054 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 nan
CHEMBL3403765 118054 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 nan
67430825 133721 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 455 10 1 5 4.4 CC[C@H](C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3714859 133721 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 455 10 1 5 4.4 CC[C@H](C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
58459797 133762 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 411 11 2 4 4.5 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2ccccc2)c(OC)c1 nan
CHEMBL3714993 133762 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 411 11 2 4 4.5 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2ccccc2)c(OC)c1 nan
51348523 133817 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 372 9 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3715159 133817 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 372 9 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
51348668 133867 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 407 7 2 4 4.7 COc1cc(-c2ccc(C)cc2)ccc1[C@H](CO)NC(=O)[C@H]1C[C@@H]1c1cccs1 nan
CHEMBL3715370 133867 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 407 7 2 4 4.7 COc1cc(-c2ccc(C)cc2)ccc1[C@H](CO)NC(=O)[C@H]1C[C@@H]1c1cccs1 nan
51348520 134010 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 401 10 2 4 4.8 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
CHEMBL3715868 134010 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 401 10 2 4 4.8 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
51348524 134118 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 387 9 2 4 4.4 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
CHEMBL3716229 134118 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 387 9 2 4 4.4 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
51348521 134159 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 387 10 2 4 4.5 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3716350 134159 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 387 10 2 4 4.5 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
51348525 134295 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 469 11 1 5 4.8 CCCC(C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3716842 134295 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 469 11 1 5 4.8 CCCC(C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
58459803 134563 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 386 9 2 4 4.4 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
CHEMBL3717751 134563 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 386 9 2 4 4.4 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
51348365 134597 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 391 7 2 3 4.9 CCc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 nan
CHEMBL3717862 134597 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 391 7 2 3 4.9 CCc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 nan
51348223 134761 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 421 8 2 4 4.9 CCc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)c(OC)c2)cc1 nan
CHEMBL3718412 134761 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 421 8 2 4 4.9 CCc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)c(OC)c2)cc1 nan
51348667 134883 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 401 10 2 4 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
CHEMBL3718798 134883 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 401 10 2 4 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
58459793 134899 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 383 7 2 4 3.9 CCCC#Cc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(OC)c1 nan
CHEMBL3718836 134899 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 383 7 2 4 3.9 CCCC#Cc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(OC)c1 nan
58459808 134988 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 385 7 1 2 5.7 CC[C@H](NC(=O)[C@H]1C[C@@H]1c1ccccc1)c1ccc(-c2ccc(OC)cc2)cc1 nan
CHEMBL3719161 134988 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 385 7 1 2 5.7 CC[C@H](NC(=O)[C@H]1C[C@@H]1c1ccccc1)c1ccc(-c2ccc(OC)cc2)cc1 nan
51348522 118054 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 nan
CHEMBL3403765 118054 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 nan
67430825 133721 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 455 10 1 5 4.4 CC[C@H](C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3714859 133721 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 455 10 1 5 4.4 CC[C@H](C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
58459797 133762 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 411 11 2 4 4.5 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2ccccc2)c(OC)c1 nan
CHEMBL3714993 133762 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 411 11 2 4 4.5 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2ccccc2)c(OC)c1 nan
51348523 133817 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 372 9 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3715159 133817 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 372 9 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
51348668 133867 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 407 7 2 4 4.7 COc1cc(-c2ccc(C)cc2)ccc1[C@H](CO)NC(=O)[C@H]1C[C@@H]1c1cccs1 nan
CHEMBL3715370 133867 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 407 7 2 4 4.7 COc1cc(-c2ccc(C)cc2)ccc1[C@H](CO)NC(=O)[C@H]1C[C@@H]1c1cccs1 nan
51348520 134010 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 401 10 2 4 4.8 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
CHEMBL3715868 134010 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 401 10 2 4 4.8 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
51348524 134118 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 387 9 2 4 4.4 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
CHEMBL3716229 134118 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 387 9 2 4 4.4 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
51348521 134159 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 387 10 2 4 4.5 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3716350 134159 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 387 10 2 4 4.5 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
51348525 134295 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 469 11 1 5 4.8 CCCC(C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3716842 134295 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 469 11 1 5 4.8 CCCC(C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
58459803 134563 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 386 9 2 4 4.4 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
CHEMBL3717751 134563 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 386 9 2 4 4.4 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
51348365 134597 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 391 7 2 3 4.9 CCc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 nan
CHEMBL3717862 134597 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 391 7 2 3 4.9 CCc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 nan
51348223 134761 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 421 8 2 4 4.9 CCc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)c(OC)c2)cc1 nan
CHEMBL3718412 134761 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 421 8 2 4 4.9 CCc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)c(OC)c2)cc1 nan
51348667 134883 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 401 10 2 4 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
CHEMBL3718798 134883 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 401 10 2 4 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
58459793 134899 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 383 7 2 4 3.9 CCCC#Cc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(OC)c1 nan
CHEMBL3718836 134899 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 383 7 2 4 3.9 CCCC#Cc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(OC)c1 nan
58459808 134988 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 385 7 1 2 5.7 CC[C@H](NC(=O)[C@H]1C[C@@H]1c1ccccc1)c1ccc(-c2ccc(OC)cc2)cc1 nan
CHEMBL3719161 134988 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 385 7 1 2 5.7 CC[C@H](NC(=O)[C@H]1C[C@@H]1c1ccccc1)c1ccc(-c2ccc(OC)cc2)cc1 nan
118727648 117609 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400239 117609 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2015.02.038
155561860 176599 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 457 10 1 4 5.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4583504 176599 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 457 10 1 4 5.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596729 176599 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 457 10 1 4 5.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
155561860 176599 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 457 10 1 4 5.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4583504 176599 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 457 10 1 4 5.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596729 176599 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 457 10 1 4 5.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
162652475 180558 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 339 8 2 3 3.4 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4752713 180558 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 339 8 2 3 3.4 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162652475 180558 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 339 8 2 3 3.4 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4752713 180558 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 339 8 2 3 3.4 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
118727668 117629 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 446 8 1 2 6.5 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400259 117629 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 446 8 1 2 6.5 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2015.02.038
118727691 117652 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 455 10 2 3 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CNC)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400282 117652 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 455 10 2 3 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CNC)cc2)cc1 10.1016/j.bmcl.2015.02.038
172461410 197496 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccncc3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5431369 197496 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccncc3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5499690 197496 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccncc3)cc2)cc1 10.1021/acs.jmedchem.2c01983
118727624 117586 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1F)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400215 117586 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1F)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
168275346 190348 None 0 Mouse Functional pEC50 = 5.2 5.2 -549 2
Agonist activity at wild type GPR88 expressed in C57BL/6J mouse striatal membrane assessed as [35S] GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at wild type GPR88 expressed in C57BL/6J mouse striatal membrane assessed as [35S] GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 477 12 2 6 4.1 CCC[C@H](C)COc1ccc([C@H](Cn2cc(C(=O)NC)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5175064 190348 None 0 Mouse Functional pEC50 = 5.2 5.2 -549 2
Agonist activity at wild type GPR88 expressed in C57BL/6J mouse striatal membrane assessed as [35S] GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at wild type GPR88 expressed in C57BL/6J mouse striatal membrane assessed as [35S] GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 477 12 2 6 4.1 CCC[C@H](C)COc1ccc([C@H](Cn2cc(C(=O)NC)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
118727683 117644 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 484 10 1 4 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CC(=O)OC)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400274 117644 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 484 10 1 4 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CC(=O)OC)cc2)cc1 10.1016/j.bmcl.2015.02.038
172459345 197473 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 487 11 1 5 5.2 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(COC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5422137 197473 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 487 11 1 5 5.2 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(COC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5499566 197473 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 487 11 1 5 5.2 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(COC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
118727666 117627 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 437 8 1 3 5.7 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(C#N)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400257 117627 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 437 8 1 3 5.7 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(C#N)cc2)cc1 10.1016/j.bmcl.2015.02.038
162663827 182061 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 461 10 2 5 4.4 Cc1cnc(CNC(=O)[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
CHEMBL4779964 182061 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 461 10 2 5 4.4 Cc1cnc(CNC(=O)[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
162663827 182061 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 461 10 2 5 4.4 Cc1cnc(CNC(=O)[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
CHEMBL4779964 182061 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 461 10 2 5 4.4 Cc1cnc(CNC(=O)[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
118730014 118077 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 359 8 2 4 3.7 CC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403791 118077 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 359 8 2 4 3.7 CC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 10.1016/j.bmcl.2015.01.036
162653251 183770 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4751633 183770 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4802826 183770 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168281316 190928 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 461 11 1 6 4.2 C[C@H](C(=O)N[C@@H](Cn1cc(CN(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5183956 190928 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 461 11 1 6 4.2 C[C@H](C(=O)N[C@@H](Cn1cc(CN(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168281316 190928 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 461 11 1 6 4.2 C[C@H](C(=O)N[C@@H](Cn1cc(CN(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5183956 190928 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 461 11 1 6 4.2 C[C@H](C(=O)N[C@@H](Cn1cc(CN(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
162653251 183770 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4751633 183770 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4802826 183770 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
118727675 117636 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 470 10 1 3 6.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400266 117636 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 470 10 1 3 6.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
58466521 1064 None 6 Human Functional pEC50 = 7.1 7.1 26 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.0c01581
7798 1064 None 6 Human Functional pEC50 = 7.1 7.1 26 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.0c01581
CHEMBL3401461 1064 None 6 Human Functional pEC50 = 7.1 7.1 26 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.0c01581
118727631 117591 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)c(F)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400222 117591 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)c(F)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
162669578 182824 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 10 2 4 5.2 C[C@H](C(=O)N[C@@H](C(=O)NCc1cccs1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4789643 182824 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 10 2 4 5.2 C[C@H](C(=O)N[C@@H](C(=O)NCc1cccs1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162669578 182824 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 10 2 4 5.2 C[C@H](C(=O)N[C@@H](C(=O)NCc1cccs1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4789643 182824 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 10 2 4 5.2 C[C@H](C(=O)N[C@@H](C(=O)NCc1cccs1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
58466521 1064 None 6 Human Functional pEC50 = 7.1 7.1 26 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.0c01581
7798 1064 None 6 Human Functional pEC50 = 7.1 7.1 26 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.0c01581
CHEMBL3401461 1064 None 6 Human Functional pEC50 = 7.1 7.1 26 2
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.0c01581
58466521 1064 None 6 Human Functional pEC50 = 7.1 7.1 26 2
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.2c01983
7798 1064 None 6 Human Functional pEC50 = 7.1 7.1 26 2
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.2c01983
CHEMBL3401461 1064 None 6 Human Functional pEC50 = 7.1 7.1 26 2
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.2c01983
58466521 1064 None 6 Human Functional pEC50 = 7.1 7.1 26 2
Agonist activity at human GPR88 expressed in HEK293T cells assessed as reduction in cAMP production incubated for 15 mins measured after 1 hr by by FLIPR assayAgonist activity at human GPR88 expressed in HEK293T cells assessed as reduction in cAMP production incubated for 15 mins measured after 1 hr by by FLIPR assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.1c01075
7798 1064 None 6 Human Functional pEC50 = 7.1 7.1 26 2
Agonist activity at human GPR88 expressed in HEK293T cells assessed as reduction in cAMP production incubated for 15 mins measured after 1 hr by by FLIPR assayAgonist activity at human GPR88 expressed in HEK293T cells assessed as reduction in cAMP production incubated for 15 mins measured after 1 hr by by FLIPR assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.1c01075
CHEMBL3401461 1064 None 6 Human Functional pEC50 = 7.1 7.1 26 2
Agonist activity at human GPR88 expressed in HEK293T cells assessed as reduction in cAMP production incubated for 15 mins measured after 1 hr by by FLIPR assayAgonist activity at human GPR88 expressed in HEK293T cells assessed as reduction in cAMP production incubated for 15 mins measured after 1 hr by by FLIPR assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.1c01075
118730002 118059 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 381 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403773 118059 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 381 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
118727643 117604 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 433 8 1 4 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1nc(C)cs1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400234 117604 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 433 8 1 4 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1nc(C)cs1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
172441488 197359 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 460 10 1 6 3.8 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5396931 197359 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 460 10 1 6 3.8 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5498663 197359 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET AssayAgonist activity at PPLS-HA tagged GPR88 (unknown origin) expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by TR-FRET Assay
ChEMBL 460 10 1 6 3.8 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
162658645 183795 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4760182 183795 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4803101 183795 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168270814 190158 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 10 1 6 3.9 C[C@H](C(=O)N[C@@H](Cn1cc(C=O)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5172064 190158 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 10 1 6 3.9 C[C@H](C(=O)N[C@@H](Cn1cc(C=O)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
58459796 134788 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 387 10 2 4 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3718508 134788 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 387 10 2 4 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
58459796 134788 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 387 10 2 4 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3718508 134788 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 387 10 2 4 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
162658645 183795 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4760182 183795 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4803101 183795 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168270814 190158 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 10 1 6 3.9 C[C@H](C(=O)N[C@@H](Cn1cc(C=O)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5172064 190158 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 10 1 6 3.9 C[C@H](C(=O)N[C@@H](Cn1cc(C=O)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
162652798 180572 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 447 10 2 5 4.1 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccon1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4752868 180572 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 447 10 2 5 4.1 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccon1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162652798 180572 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 447 10 2 5 4.1 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccon1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4752868 180572 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 447 10 2 5 4.1 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccon1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
118727673 117634 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 468 8 1 2 7.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(C(C)(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400264 117634 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 468 8 1 2 7.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(C(C)(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
168274798 190200 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 450 12 2 6 4.2 CCC[C@H](C)COc1ccc([C@H](Cn2cc(CO)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5172809 190200 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 450 12 2 6 4.2 CCC[C@H](C)COc1ccc([C@H](Cn2cc(CO)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
162665334 183836 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4783876 183836 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4803469 183836 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
118727629 117589 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cc(F)ccc1F)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400220 117589 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cc(F)ccc1F)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
162665334 183836 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4783876 183836 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4803469 183836 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
134131406 142407 None 0 Human Functional pEC50 = 5.1 5.1 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccccc2F)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885445 142407 None 0 Human Functional pEC50 = 5.1 5.1 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccccc2F)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
162644557 179559 None 0 Human Functional pEC50 = 5.1 5.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 425 12 3 4 3.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4740613 179559 None 0 Human Functional pEC50 = 5.1 5.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 425 12 3 4 3.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN)cc1 10.1021/acs.jmedchem.0c01581
162644557 179559 None 0 Human Functional pEC50 = 5.1 5.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 425 12 3 4 3.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4740613 179559 None 0 Human Functional pEC50 = 5.1 5.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 425 12 3 4 3.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN)cc1 10.1021/acs.jmedchem.0c01581
134131406 142407 None 0 Human Functional pEC50 = 5.1 5.1 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccccc2F)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885445 142407 None 0 Human Functional pEC50 = 5.1 5.1 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccccc2F)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
58466533 135238 None 0 Human Functional pEC50 = 8.1 8.1 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 489 10 1 4 6.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
CHEMBL3714828 135238 None 0 Human Functional pEC50 = 8.1 8.1 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 489 10 1 4 6.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
CHEMBL3719582 135238 None 0 Human Functional pEC50 = 8.1 8.1 - 1
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 489 10 1 4 6.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
58466533 135238 None 0 Human Functional pEC50 = 8.1 8.1 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 489 10 1 4 6.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
CHEMBL3714828 135238 None 0 Human Functional pEC50 = 8.1 8.1 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 489 10 1 4 6.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
CHEMBL3719582 135238 None 0 Human Functional pEC50 = 8.1 8.1 - 1
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 489 10 1 4 6.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
118727670 117631 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400261 117631 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
51348370 134839 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@@H]3C[C@H]3c3cccs3)cc2)cc1 nan
CHEMBL3718649 134839 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@@H]3C[C@H]3c3cccs3)cc2)cc1 nan
51348370 134839 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@@H]3C[C@H]3c3cccs3)cc2)cc1 nan
CHEMBL3718649 134839 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@@H]3C[C@H]3c3cccs3)cc2)cc1 nan
51355598 117560 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 385 11 3 4 3.4 CCCC(C)COc1ccc([C@H](CO)NC(=O)C(CO)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3400186 117560 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 385 11 3 4 3.4 CCCC(C)COc1ccc([C@H](CO)NC(=O)C(CO)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
118730005 118063 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 384 11 3 4 3.6 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](NC)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403777 118063 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 384 11 3 4 3.6 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](NC)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
162673915 183139 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccncc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4793946 183139 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccncc2)cc1 10.1021/acs.jmedchem.0c01581
162673915 183139 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccncc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4793946 183139 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccncc2)cc1 10.1021/acs.jmedchem.0c01581
118730161 118114 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3404048 118114 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
168278367 191289 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 1 5 4.4 Cc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5189064 191289 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 1 5 4.4 Cc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
51354740 133771 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 465 12 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715014 133771 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 465 12 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354740 133771 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 465 12 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715014 133771 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 465 12 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
168278367 191289 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 1 5 4.4 Cc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5189064 191289 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 1 5 4.4 Cc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168275346 190348 None 0 Mouse Functional pEC50 = 5.1 5.1 -549 2
Agonist activity at wild type GPR88 expressed in mouse striatal membrane assessed as [35S] GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at wild type GPR88 expressed in mouse striatal membrane assessed as [35S] GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 477 12 2 6 4.1 CCC[C@H](C)COc1ccc([C@H](Cn2cc(C(=O)NC)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5175064 190348 None 0 Mouse Functional pEC50 = 5.1 5.1 -549 2
Agonist activity at wild type GPR88 expressed in mouse striatal membrane assessed as [35S] GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at wild type GPR88 expressed in mouse striatal membrane assessed as [35S] GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 477 12 2 6 4.1 CCC[C@H](C)COc1ccc([C@H](Cn2cc(C(=O)NC)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
162657387 181183 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 525 13 3 5 5.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCNC(=O)OC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4759904 181183 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 525 13 3 5 5.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCNC(=O)OC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
162657387 181183 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 525 13 3 5 5.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCNC(=O)OC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4759904 181183 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 525 13 3 5 5.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCNC(=O)OC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
51355880 118068 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 451 11 1 4 4.7 CCCC(C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403782 118068 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 451 11 1 4 4.7 CCCC(C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
118727676 117637 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 456 10 1 3 6.3 CCOc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400267 117637 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 456 10 1 3 6.3 CCOc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
118727663 117624 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400254 117624 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2015.02.038
168269202 190124 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 434 10 2 6 3.6 C[C@H](C(=O)N[C@@H](Cn1cc(CO)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5171567 190124 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 434 10 2 6 3.6 C[C@H](C(=O)N[C@@H](Cn1cc(CO)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168296691 192330 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 447 10 2 6 3.2 C[C@H](C(=O)N[C@@H](Cn1cc(C(N)=O)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5204827 192330 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 447 10 2 6 3.2 C[C@H](C(=O)N[C@@H](Cn1cc(C(N)=O)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
51356141 118069 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 438 11 1 4 4.8 CCCC(C)COc1ccc([C@H](CN2CCOCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403783 118069 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 438 11 1 4 4.8 CCCC(C)COc1ccc([C@H](CN2CCOCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
168269202 190124 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 434 10 2 6 3.6 C[C@H](C(=O)N[C@@H](Cn1cc(CO)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5171567 190124 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 434 10 2 6 3.6 C[C@H](C(=O)N[C@@H](Cn1cc(CO)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168296691 192330 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 447 10 2 6 3.2 C[C@H](C(=O)N[C@@H](Cn1cc(C(N)=O)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5204827 192330 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 447 10 2 6 3.2 C[C@H](C(=O)N[C@@H](Cn1cc(C(N)=O)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168288752 191532 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 488 14 1 5 6.2 CCCCCCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5192812 191532 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 488 14 1 5 6.2 CCCCCCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168288752 191532 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 488 14 1 5 6.2 CCCCCCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5192812 191532 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 488 14 1 5 6.2 CCCCCCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
51348522 118054 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403765 118054 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 10.1016/j.bmcl.2015.01.036
118727678 117639 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 504 10 1 3 7.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(Oc3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400269 117639 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 504 10 1 3 7.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(Oc3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
162665470 182904 None 0 Mouse Functional pEC50 = 6.0 6.0 -15 2
Agonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation countingAgonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation counting
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4784623 182904 None 0 Mouse Functional pEC50 = 6.0 6.0 -15 2
Agonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation countingAgonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation counting
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4790638 182904 None 0 Mouse Functional pEC50 = 6.0 6.0 -15 2
Agonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation countingAgonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation counting
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168275176 190761 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 1 5 4.1 C[C@H](C(=O)N[C@@H](Cn1ccnn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5181466 190761 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 1 5 4.1 C[C@H](C(=O)N[C@@H](Cn1ccnn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168275176 190761 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 1 5 4.1 C[C@H](C(=O)N[C@@H](Cn1ccnn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5181466 190761 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 1 5 4.1 C[C@H](C(=O)N[C@@H](Cn1ccnn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
134130076 142356 None 0 Human Functional pEC50 = 5.0 5.0 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 413 11 1 5 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(OC)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884939 142356 None 0 Human Functional pEC50 = 5.0 5.0 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 413 11 1 5 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(OC)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
134130076 142356 None 0 Human Functional pEC50 = 5.0 5.0 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 413 11 1 5 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(OC)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884939 142356 None 0 Human Functional pEC50 = 5.0 5.0 - 1
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 413 11 1 5 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(OC)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
155525986 171130 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 443 9 1 4 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4456708 171130 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 443 9 1 4 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC)cc2)cc1 10.1021/acs.jmedchem.8b00566
118727630 117590 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cc(F)cc(F)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400221 117590 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cc(F)cc(F)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727686 117647 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 483 9 1 3 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(C(=O)N(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400277 117647 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 483 9 1 3 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(C(=O)N(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
12395 3411 None 1 Human Functional pEC50 = 8.0 8.0 14 2
Agonist potency determined in a TR-FRET cAMP assay using CHO cells expressing hGPR88Agonist potency determined in a TR-FRET cAMP assay using CHO cells expressing hGPR88
Guide to Pharmacology 491 10 1 5 5.2 N[C@@H]([C@@H](C)OC)CN(C(=O)[C@H]1[C@H](c2ccc(F)cn2)C1)c1ccc(c2ccc(OC(C)C)cc2)cc1 36749855
167993640 3411 None 1 Human Functional pEC50 = 8.0 8.0 14 2
Agonist potency determined in a TR-FRET cAMP assay using CHO cells expressing hGPR88Agonist potency determined in a TR-FRET cAMP assay using CHO cells expressing hGPR88
Guide to Pharmacology 491 10 1 5 5.2 N[C@@H]([C@@H](C)OC)CN(C(=O)[C@H]1[C@H](c2ccc(F)cn2)C1)c1ccc(c2ccc(OC(C)C)cc2)cc1 36749855
CHEMBL5498825 3411 None 1 Human Functional pEC50 = 8.0 8.0 14 2
Agonist potency determined in a TR-FRET cAMP assay using CHO cells expressing hGPR88Agonist potency determined in a TR-FRET cAMP assay using CHO cells expressing hGPR88
Guide to Pharmacology 491 10 1 5 5.2 N[C@@H]([C@@H](C)OC)CN(C(=O)[C@H]1[C@H](c2ccc(F)cn2)C1)c1ccc(c2ccc(OC(C)C)cc2)cc1 36749855
10031 3412 None 10 Human Functional pEC50 = 7.6 7.6 2 2
In an <i>in vitro</i> cAMP functional assay.In an <i>in vitro</i> cAMP functional assay.
Guide to Pharmacology 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 30011199
134813902 3412 None 10 Human Functional pEC50 = 7.6 7.6 2 2
In an <i>in vitro</i> cAMP functional assay.In an <i>in vitro</i> cAMP functional assay.
Guide to Pharmacology 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 30011199
CHEMBL4595209 3412 None 10 Human Functional pEC50 = 7.6 7.6 2 2
In an <i>in vitro</i> cAMP functional assay.In an <i>in vitro</i> cAMP functional assay.
Guide to Pharmacology 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 30011199
58466521 1064 None 6 Human Functional pEC50 = 6.2 6.2 26 2
UnclassifiedUnclassified
Guide to Pharmacology 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 24793972
7798 1064 None 6 Human Functional pEC50 = 6.2 6.2 26 2
UnclassifiedUnclassified
Guide to Pharmacology 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 24793972
CHEMBL3401461 1064 None 6 Human Functional pEC50 = 6.2 6.2 26 2
UnclassifiedUnclassified
Guide to Pharmacology 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 24793972


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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type		 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

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 DOI
172463593 197511 None 0 Human Binding pEC50 = 5 5.0 - 0
Displacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assayDisplacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@H]3C[C@@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5429768 197511 None 0 Human Binding pEC50 = 5 5.0 - 0
Displacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assayDisplacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@H]3C[C@@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5499810 197511 None 0 Human Binding pEC50 = 5 5.0 - 0
Displacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assayDisplacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@H]3C[C@@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.2c01983
12395 3411 None 1 Human Binding pEC50 = 7.9 7.9 - 0
Displacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assayDisplacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assay
ChEMBL 491 10 1 5 5.2 N[C@@H]([C@@H](C)OC)CN(C(=O)[C@H]1[C@H](c2ccc(F)cn2)C1)c1ccc(c2ccc(OC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
167993640 3411 None 1 Human Binding pEC50 = 7.9 7.9 - 0
Displacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assayDisplacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assay
ChEMBL 491 10 1 5 5.2 N[C@@H]([C@@H](C)OC)CN(C(=O)[C@H]1[C@H](c2ccc(F)cn2)C1)c1ccc(c2ccc(OC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5498825 3411 None 1 Human Binding pEC50 = 7.9 7.9 - 0
Displacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assayDisplacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assay
ChEMBL 491 10 1 5 5.2 N[C@@H]([C@@H](C)OC)CN(C(=O)[C@H]1[C@H](c2ccc(F)cn2)C1)c1ccc(c2ccc(OC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
12395 3411 None 1 Mouse Binding pEC50 = 6.8 6.8 - 0
Displacement of [35S]GTPgammaS from mouse striatal membrane GPR88 incubated for 60 mins by radioligand binding assayDisplacement of [35S]GTPgammaS from mouse striatal membrane GPR88 incubated for 60 mins by radioligand binding assay
ChEMBL 491 10 1 5 5.2 N[C@@H]([C@@H](C)OC)CN(C(=O)[C@H]1[C@H](c2ccc(F)cn2)C1)c1ccc(c2ccc(OC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
167993640 3411 None 1 Mouse Binding pEC50 = 6.8 6.8 - 0
Displacement of [35S]GTPgammaS from mouse striatal membrane GPR88 incubated for 60 mins by radioligand binding assayDisplacement of [35S]GTPgammaS from mouse striatal membrane GPR88 incubated for 60 mins by radioligand binding assay
ChEMBL 491 10 1 5 5.2 N[C@@H]([C@@H](C)OC)CN(C(=O)[C@H]1[C@H](c2ccc(F)cn2)C1)c1ccc(c2ccc(OC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5498825 3411 None 1 Mouse Binding pEC50 = 6.8 6.8 - 0
Displacement of [35S]GTPgammaS from mouse striatal membrane GPR88 incubated for 60 mins by radioligand binding assayDisplacement of [35S]GTPgammaS from mouse striatal membrane GPR88 incubated for 60 mins by radioligand binding assay
ChEMBL 491 10 1 5 5.2 N[C@@H]([C@@H](C)OC)CN(C(=O)[C@H]1[C@H](c2ccc(F)cn2)C1)c1ccc(c2ccc(OC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
134128290 194406 None 3 Human Binding pEC50 = 5.8 5.8 - 1
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@H]3C[C@@H]3c3ccccn3)cc2)cc1 10.1016/j.bmcl.2022.129120
CHEMBL5285428 194406 None 3 Human Binding pEC50 = 5.8 5.8 - 1
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@H]3C[C@@H]3c3ccccn3)cc2)cc1 10.1016/j.bmcl.2022.129120
51356430 118057 None 0 Human Binding pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120
CHEMBL3403768 118057 None 0 Human Binding pEC50 = 6.7 6.7 - 1
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120
58466401 118066 None 0 Human Binding pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120
CHEMBL3403780 118066 None 0 Human Binding pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120
CHEMBL3884102 118066 None 0 Human Binding pEC50 = 6.5 6.5 - 1
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120
10031 3412 None 10 Human Binding pEC50 = 7.4 7.4 -3 3
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
134813902 3412 None 10 Human Binding pEC50 = 7.4 7.4 -3 3
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
CHEMBL4595209 3412 None 10 Human Binding pEC50 = 7.4 7.4 -3 3
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
10031 3412 None 10 Human Binding pEC50 = 7.2 7.2 -3 3
Displacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assayDisplacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.2c01983
134813902 3412 None 10 Human Binding pEC50 = 7.2 7.2 -3 3
Displacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assayDisplacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.2c01983
CHEMBL4595209 3412 None 10 Human Binding pEC50 = 7.2 7.2 -3 3
Displacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assayDisplacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.2c01983
58466521 1064 None 6 Human Binding pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmcl.2022.129120
7798 1064 None 6 Human Binding pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmcl.2022.129120
CHEMBL3401461 1064 None 6 Human Binding pEC50 = 7.1 7.1 - 1
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmcl.2022.129120
58466401 118066 None 0 Mouse Binding pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 in mouse striatal membranes assessed as increase in [35S]-GTP-gammaS bindingAgonist activity at GPR88 in mouse striatal membranes assessed as increase in [35S]-GTP-gammaS binding
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3403780 118066 None 0 Mouse Binding pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 in mouse striatal membranes assessed as increase in [35S]-GTP-gammaS bindingAgonist activity at GPR88 in mouse striatal membranes assessed as increase in [35S]-GTP-gammaS binding
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884102 118066 None 0 Mouse Binding pEC50 = 6.0 6.0 - 1
Agonist activity at GPR88 in mouse striatal membranes assessed as increase in [35S]-GTP-gammaS bindingAgonist activity at GPR88 in mouse striatal membranes assessed as increase in [35S]-GTP-gammaS binding
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
172469753 197560 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Displacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assayDisplacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assay
ChEMBL 491 10 1 5 5.2 CO[C@H](C)[C@H](N)CN(C(=O)[C@H]1C[C@@H]1c1ccc(F)cn1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5437290 197560 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Displacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assayDisplacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assay
ChEMBL 491 10 1 5 5.2 CO[C@H](C)[C@H](N)CN(C(=O)[C@H]1C[C@@H]1c1ccc(F)cn1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
CHEMBL5500144 197560 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Displacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assayDisplacement of [35S]GTPgammaS from PPLS-HA tagged human GPR88 overexpressed in CHO cells membrane incubated for 60 mins radioligand binding assay
ChEMBL 491 10 1 5 5.2 CO[C@H](C)[C@H](N)CN(C(=O)[C@H]1C[C@@H]1c1ccc(F)cn1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 10.1021/acs.jmedchem.2c01983
10031 3412 None 10 Mouse Binding pKd = 7.4 7.4 3 3
Binding affinity to GPR88 in mouse striatal membrane by filtration methodBinding affinity to GPR88 in mouse striatal membrane by filtration method
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
134813902 3412 None 10 Mouse Binding pKd = 7.4 7.4 3 3
Binding affinity to GPR88 in mouse striatal membrane by filtration methodBinding affinity to GPR88 in mouse striatal membrane by filtration method
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
CHEMBL4595209 3412 None 10 Mouse Binding pKd = 7.4 7.4 3 3
Binding affinity to GPR88 in mouse striatal membrane by filtration methodBinding affinity to GPR88 in mouse striatal membrane by filtration method
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
10031 3412 None 10 Human Binding pKd = 7.1 7.1 -3 3
Binding affinity to PPLS-HA tagged human GPR88 expressed in CHO cell membrane by filtration methodBinding affinity to PPLS-HA tagged human GPR88 expressed in CHO cell membrane by filtration method
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
134813902 3412 None 10 Human Binding pKd = 7.1 7.1 -3 3
Binding affinity to PPLS-HA tagged human GPR88 expressed in CHO cell membrane by filtration methodBinding affinity to PPLS-HA tagged human GPR88 expressed in CHO cell membrane by filtration method
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
CHEMBL4595209 3412 None 10 Human Binding pKd = 7.1 7.1 -3 3
Binding affinity to PPLS-HA tagged human GPR88 expressed in CHO cell membrane by filtration methodBinding affinity to PPLS-HA tagged human GPR88 expressed in CHO cell membrane by filtration method
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
58466401 118066 None 0 Human Binding pKi = 6.7 6.7 - 1
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120
CHEMBL3403780 118066 None 0 Human Binding pKi = 6.7 6.7 - 1
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120
CHEMBL3884102 118066 None 0 Human Binding pKi = 6.7 6.7 - 1
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120
10031 3412 None 10 Human Binding pKi = 6.7 6.7 -3 3
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
134813902 3412 None 10 Human Binding pKi = 6.7 6.7 -3 3
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
CHEMBL4595209 3412 None 10 Human Binding pKi = 6.7 6.7 -3 3
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
58466521 1064 None 6 Human Binding pKi = 6.6 6.6 - 1
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmcl.2022.129120
7798 1064 None 6 Human Binding pKi = 6.6 6.6 - 1
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmcl.2022.129120
CHEMBL3401461 1064 None 6 Human Binding pKi = 6.6 6.6 - 1
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmcl.2022.129120
134128290 194406 None 3 Human Binding pKi = 6.3 6.3 - 1
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@H]3C[C@@H]3c3ccccn3)cc2)cc1 10.1016/j.bmcl.2022.129120
CHEMBL5285428 194406 None 3 Human Binding pKi = 6.3 6.3 - 1
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@H]3C[C@@H]3c3ccccn3)cc2)cc1 10.1016/j.bmcl.2022.129120
51356430 118057 None 0 Human Binding pKi = 6.2 6.2 - 1
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120
CHEMBL3403768 118057 None 0 Human Binding pKi = 6.2 6.2 - 1
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120