Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 162644596 | 179525 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | |||
| CHEMBL4740228 | 179525 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | |||
| 153585580 | 179550 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 411 | 6 | 1 | 8 | 1.7 | COc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | |||
| CHEMBL4740491 | 179550 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 411 | 6 | 1 | 8 | 1.7 | COc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | |||
| 153585418 | 179553 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 434 | 5 | 1 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4740519 | 179553 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 434 | 5 | 1 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 148659040 | 179670 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 388 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(Br)n3c2=O)cc1 | nan | |||
| CHEMBL4741806 | 179670 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 388 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(Br)n3c2=O)cc1 | nan | |||
| 153585598 | 179721 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 446 | 5 | 1 | 7 | 1.9 | C[C@H](NC(=O)Cn1nc2cccc(N3CCN(C)CC3)n2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4742673 | 179721 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 446 | 5 | 1 | 7 | 1.9 | C[C@H](NC(=O)Cn1nc2cccc(N3CCN(C)CC3)n2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 148397968 | 179741 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | |||
| CHEMBL4742901 | 179741 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | |||
| 147048009 | 179763 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 388 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(Br)cn3c2=O)cc1 | nan | |||
| CHEMBL4743199 | 179763 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 388 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(Br)cn3c2=O)cc1 | nan | |||
| 147451915 | 179793 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 348 | 4 | 1 | 5 | 2.2 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4743612 | 179793 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 348 | 4 | 1 | 5 | 2.2 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 152956498 | 179816 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 324 | 4 | 1 | 5 | 2.2 | Cc1ccc([C@H](C)NC(=O)C(C)n2nc3ccccn3c2=O)cc1 | nan | |||
| CHEMBL4743938 | 179816 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 324 | 4 | 1 | 5 | 2.2 | Cc1ccc([C@H](C)NC(=O)C(C)n2nc3ccccn3c2=O)cc1 | nan | |||
| 153585490 | 179847 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ncccn2c1=O | nan | |||
| CHEMBL4744169 | 179847 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ncccn2c1=O | nan | |||
| 153585688 | 179864 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4744340 | 179864 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 162647825 | 179941 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 | nan | |||
| CHEMBL4745096 | 179941 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 | nan | |||
| 152005060 | 179968 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 447 | 5 | 1 | 8 | 1.3 | C[C@H](NC(=O)Cn1nc2c(N3CCN(C)CC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4745432 | 179968 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 447 | 5 | 1 | 8 | 1.3 | C[C@H](NC(=O)Cn1nc2c(N3CCN(C)CC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 150944515 | 179970 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 425 | 5 | 2 | 7 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(NC(=O)OC(C)(C)C)cccn3c2=O)cc1 | nan | |||
| CHEMBL4745487 | 179970 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 425 | 5 | 2 | 7 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(NC(=O)OC(C)(C)C)cccn3c2=O)cc1 | nan | |||
| 147626442 | 179985 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1cn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2cn1 | nan | |||
| CHEMBL4745668 | 179985 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1cn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2cn1 | nan | |||
| 150995037 | 180025 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cnccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4746108 | 180025 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cnccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 162648023 | 180081 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 452 | 7 | 2 | 9 | 1.5 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4746822 | 180081 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 452 | 7 | 2 | 9 | 1.5 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 153585512 | 180134 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 367 | 4 | 1 | 6 | 1.7 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4747431 | 180134 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 367 | 4 | 1 | 6 | 1.7 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 162650006 | 180231 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2cccnn2c1=O | nan | |||
| CHEMBL4748681 | 180231 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2cccnn2c1=O | nan | |||
| 153585452 | 180317 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL4749705 | 180317 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)cc1 | nan | |||
| 151976938 | 180346 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 | nan | |||
| CHEMBL4750143 | 180346 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 | nan | |||
| 147634500 | 180384 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F | nan | |||
| CHEMBL4750692 | 180384 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F | nan | |||
| 149094095 | 180388 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 421 | 6 | 1 | 7 | 2.5 | C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4750718 | 180388 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 421 | 6 | 1 | 7 | 2.5 | C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 152023194 | 180436 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(Cl)cccn3c2=O)cc1 | nan | |||
| CHEMBL4751203 | 180436 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(Cl)cccn3c2=O)cc1 | nan | |||
| 153585601 | 180443 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 478 | 6 | 1 | 8 | 2.0 | C[C@H](NC(=O)Cn1nc2cccc(N3CCN(C)CC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4751259 | 180443 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 478 | 6 | 1 | 8 | 2.0 | C[C@H](NC(=O)Cn1nc2cccc(N3CCN(C)CC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 153585718 | 180447 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4751304 | 180447 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585541 | 180487 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 341 | 5 | 1 | 7 | 1.1 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc2n1 | nan | |||
| CHEMBL4751720 | 180487 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 341 | 5 | 1 | 7 | 1.1 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc2n1 | nan | |||
| 153585550 | 180499 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 10 | 2 | ChEMBL | 355 | 5 | 1 | 6 | 1.8 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(C2CC2)c(F)c1 | nan | |||
| CHEMBL4751886 | 180499 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 10 | 2 | ChEMBL | 355 | 5 | 1 | 6 | 1.8 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(C2CC2)c(F)c1 | nan | |||
| 153585655 | 180582 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 493 | 7 | 1 | 8 | 2.9 | COC1CCN(c2ccn3c(=O)n(CC(=O)N[C@@H](C)c4ccc(OC(F)(F)F)cc4)nc3c2)CC1 | nan | |||
| CHEMBL4752993 | 180582 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 493 | 7 | 1 | 8 | 2.9 | COC1CCN(c2ccn3c(=O)n(CC(=O)N[C@@H](C)c4ccc(OC(F)(F)F)cc4)nc3c2)CC1 | nan | |||
| 147378727 | 180633 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 380 | 6 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)c(F)c1 | nan | |||
| CHEMBL4753547 | 180633 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 380 | 6 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)c(F)c1 | nan | |||
| 162653797 | 180636 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1F | nan | |||
| CHEMBL4753587 | 180636 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1F | nan | |||
| 150050373 | 180701 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 339 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(C)nc(C)n3c2=O)cc1 | nan | |||
| CHEMBL4754384 | 180701 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 339 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(C)nc(C)n3c2=O)cc1 | nan | |||
| 149101043 | 180709 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4754476 | 180709 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 153585478 | 180711 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4754503 | 180711 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 153585445 | 180863 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 382 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| CHEMBL4756137 | 180863 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 382 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| 153585588 | 180892 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 10 | 2 | ChEMBL | 444 | 5 | 2 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CNC4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4756392 | 180892 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 10 | 2 | ChEMBL | 444 | 5 | 2 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CNC4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585712 | 180897 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 419 | 6 | 2 | 7 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(NC3COC3)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4756431 | 180897 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 419 | 6 | 2 | 7 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(NC3COC3)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 94095050 | 180917 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 380 | 5 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4756787 | 180917 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 380 | 5 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 153585575 | 180935 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 10 | 2 | ChEMBL | 433 | 5 | 2 | 8 | 1.0 | C[C@H](NC(=O)Cn1nc2c(N3CCNCC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4756937 | 180935 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 10 | 2 | ChEMBL | 433 | 5 | 2 | 8 | 1.0 | C[C@H](NC(=O)Cn1nc2c(N3CCNCC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 162656575 | 180989 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 355 | 5 | 1 | 6 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)c(F)c1 | nan | |||
| CHEMBL4757480 | 180989 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 355 | 5 | 1 | 6 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)c(F)c1 | nan | |||
| 153585415 | 180994 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 10 | 2 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O | nan | |||
| CHEMBL4757506 | 180994 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 10 | 2 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O | nan | |||
| 162656504 | 181002 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 420 | 6 | 2 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4757619 | 181002 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 420 | 6 | 2 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585404 | 181014 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 | nan | |||
| CHEMBL4757742 | 181014 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 | nan | |||
| 149421402 | 181062 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 452 | 7 | 1 | 8 | 2.1 | C[C@H](NC(=O)Cn1nc2cc(OC3COC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4758375 | 181062 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 452 | 7 | 1 | 8 | 2.1 | C[C@H](NC(=O)Cn1nc2cc(OC3COC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 162657688 | 181161 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)ccc1Cl | nan | |||
| CHEMBL4759611 | 181161 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)ccc1Cl | nan | |||
| 153585534 | 181190 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 10 | 2 | ChEMBL | 413 | 5 | 1 | 7 | 2.1 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 | nan | |||
| CHEMBL4759991 | 181190 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 10 | 2 | ChEMBL | 413 | 5 | 1 | 7 | 2.1 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 | nan | |||
| 162657416 | 181226 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | |||
| CHEMBL4760528 | 181226 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | |||
| 153585663 | 181261 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 10 | 2 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1Cl | nan | |||
| CHEMBL4760812 | 181261 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 10 | 2 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1Cl | nan | |||
| 153585574 | 181327 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)[C@@H](C)n1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4761321 | 181327 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)[C@@H](C)n1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 162660420 | 181381 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 363 | 5 | 1 | 6 | 2.0 | CC[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4762121 | 181381 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 363 | 5 | 1 | 6 | 2.0 | CC[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 147987797 | 181390 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 364 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| CHEMBL4762206 | 181390 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 364 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| 153585643 | 181447 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 10 | 2 | ChEMBL | 381 | 5 | 1 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4762957 | 181447 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 10 | 2 | ChEMBL | 381 | 5 | 1 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 147323186 | 181490 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 325 | 4 | 1 | 6 | 1.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cnc(C)cn3c2=O)cc1 | nan | |||
| CHEMBL4763362 | 181490 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 325 | 4 | 1 | 6 | 1.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cnc(C)cn3c2=O)cc1 | nan | |||
| 153585610 | 181551 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ccccn2c1=O | nan | |||
| CHEMBL4764290 | 181551 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ccccn2c1=O | nan | |||
| 162661581 | 181570 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 362 | 4 | 1 | 5 | 2.7 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ccccn2c1=O | nan | |||
| CHEMBL4764506 | 181570 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 362 | 4 | 1 | 5 | 2.7 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ccccn2c1=O | nan | |||
| 153585681 | 181589 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4764666 | 181589 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 152494840 | 181603 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC(O)CC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4764839 | 181603 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC(O)CC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 134043805 | 181875 | None | 1 | Human | Functional | pEC50 | = | 9 | 9.0 | 3 | 2 | ChEMBL | 362 | 6 | 1 | 6 | 2.0 | CC(NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)cc1 | nan | |||
| CHEMBL4777673 | 181875 | None | 1 | Human | Functional | pEC50 | = | 9 | 9.0 | 3 | 2 | ChEMBL | 362 | 6 | 1 | 6 | 2.0 | CC(NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)cc1 | nan | |||
| 162665057 | 182172 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | |||
| CHEMBL4781404 | 182172 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | |||
| 149618414 | 182367 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 325 | 4 | 2 | 6 | 1.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(N)cccn3c2=O)cc1 | nan | |||
| CHEMBL4783739 | 182367 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 325 | 4 | 2 | 6 | 1.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(N)cccn3c2=O)cc1 | nan | |||
| 153585453 | 182374 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 431 | 6 | 1 | 7 | 2.6 | C[C@H](NC(=O)Cn1nc2c(C(F)F)nccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4783815 | 182374 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 431 | 6 | 1 | 7 | 2.6 | C[C@H](NC(=O)Cn1nc2c(C(F)F)nccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 153585542 | 182412 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 10 | 2 | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | |||
| CHEMBL4784153 | 182412 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 10 | 2 | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | |||
| 151570395 | 182493 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)n2c1 | nan | |||
| CHEMBL4785283 | 182493 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)n2c1 | nan | |||
| 153585417 | 182533 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1Cl | nan | |||
| CHEMBL4785963 | 182533 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1Cl | nan | |||
| 162667558 | 182568 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 10 | 2 | ChEMBL | 331 | 4 | 1 | 6 | 1.4 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL4786371 | 182568 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 10 | 2 | ChEMBL | 331 | 4 | 1 | 6 | 1.4 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)cc1 | nan | |||
| 153585609 | 182578 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 465 | 6 | 1 | 8 | 2.1 | C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4786573 | 182578 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 465 | 6 | 1 | 8 | 2.1 | C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 151394869 | 182642 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4787308 | 182642 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 151043804 | 182781 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4789123 | 182781 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 162670176 | 182857 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 377 | 5 | 1 | 6 | 2.2 | CC(C)[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4790080 | 182857 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 377 | 5 | 1 | 6 | 2.2 | CC(C)[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 150234341 | 182896 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1ccnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 | nan | |||
| CHEMBL4790498 | 182896 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1ccnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 | nan | |||
| 149881970 | 182960 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2n1 | nan | |||
| CHEMBL4791551 | 182960 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2n1 | nan | |||
| 149784975 | 182984 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccncn3c2=O)cc1 | nan | |||
| CHEMBL4791843 | 182984 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccncn3c2=O)cc1 | nan | |||
| 162670473 | 183016 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 | nan | |||
| CHEMBL4792356 | 183016 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 | nan | |||
| 153585679 | 183029 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1F | nan | |||
| CHEMBL4792515 | 183029 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1F | nan | |||
| 162671011 | 183050 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n2n1 | nan | |||
| CHEMBL4792732 | 183050 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n2n1 | nan | |||
| 153585435 | 183100 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 359 | 4 | 1 | 6 | 2.0 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc2n1 | nan | |||
| CHEMBL4793463 | 183100 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 359 | 4 | 1 | 6 | 2.0 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc2n1 | nan | |||
| 153585524 | 183236 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(F)cccn3c2=O)cc1 | nan | |||
| CHEMBL4795078 | 183236 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(F)cccn3c2=O)cc1 | nan | |||
| 153585386 | 183339 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2ccc(Cl)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4796254 | 183339 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2ccc(Cl)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 153585438 | 183466 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2c1 | nan | |||
| CHEMBL4797724 | 183466 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2c1 | nan | |||
| 153585532 | 183498 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(F)n3c2=O)cc1 | nan | |||
| CHEMBL4798029 | 183498 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(F)n3c2=O)cc1 | nan | |||
| 162675990 | 183524 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 375 | 5 | 1 | 6 | 2.0 | O=C(Cn1nc2cccnn2c1=O)N[C@H](c1ccc(Cl)c(F)c1)C1CC1 | nan | |||
| CHEMBL4798509 | 183524 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 375 | 5 | 1 | 6 | 2.0 | O=C(Cn1nc2cccnn2c1=O)N[C@H](c1ccc(Cl)c(F)c1)C1CC1 | nan | |||
| 153585488 | 183573 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | |||
| CHEMBL4799144 | 183573 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | |||
| 153585707 | 183684 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 361 | 5 | 1 | 7 | 1.4 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc2n1 | nan | |||
| CHEMBL4800487 | 183684 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | ChEMBL | 361 | 5 | 1 | 7 | 1.4 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc2n1 | nan | |||
| 153585650 | 179510 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 381 | 5 | 1 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4740004 | 179510 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 381 | 5 | 1 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 162644596 | 179525 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 1 | 2 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | |||
| CHEMBL4740228 | 179525 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 1 | 2 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | |||
| 162648528 | 179920 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 1 | 2 | ChEMBL | 337 | 5 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)cc1 | nan | |||
| CHEMBL4744984 | 179920 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 1 | 2 | ChEMBL | 337 | 5 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)cc1 | nan | |||
| 146867363 | 179982 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 465 | 7 | 1 | 8 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(OC3CN(C)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4745642 | 179982 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 465 | 7 | 1 | 8 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(OC3CN(C)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 162649809 | 180151 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 1 | 2 | ChEMBL | 458 | 5 | 1 | 7 | 2.1 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CN(C)C4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4747632 | 180151 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 1 | 2 | ChEMBL | 458 | 5 | 1 | 7 | 2.1 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CN(C)C4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585543 | 180342 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1 | nan | |||
| CHEMBL4750043 | 180342 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1 | nan | |||
| 153585514 | 180479 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | -10 | 2 | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1 | nan | |||
| CHEMBL4751629 | 180479 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | -10 | 2 | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1 | nan | |||
| 153585659 | 180738 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 381 | 6 | 1 | 7 | 1.5 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(OC(F)F)c(F)c1 | nan | |||
| CHEMBL4754933 | 180738 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 381 | 6 | 1 | 7 | 1.5 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(OC(F)F)c(F)c1 | nan | |||
| 153585592 | 180849 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 464 | 6 | 2 | 8 | 1.7 | C[C@H](NC(=O)Cn1nc2cccc(N3CCNCC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4755986 | 180849 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 464 | 6 | 2 | 8 | 1.7 | C[C@H](NC(=O)Cn1nc2cccc(N3CCNCC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 133916051 | 181355 | None | 1 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 356 | 5 | 1 | 5 | 2.4 | O=C(Cn1nc2ccccn2c1=O)NC(c1ccc(Cl)cc1)C1CC1 | nan | |||
| CHEMBL4761733 | 181355 | None | 1 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 356 | 5 | 1 | 5 | 2.4 | O=C(Cn1nc2ccccn2c1=O)NC(c1ccc(Cl)cc1)C1CC1 | nan | |||
| 153065968 | 181384 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 354 | 6 | 1 | 6 | 2.2 | CC(C)Oc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 | nan | |||
| CHEMBL4762154 | 181384 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 354 | 6 | 1 | 6 | 2.2 | CC(C)Oc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 | nan | |||
| 153585680 | 181392 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 314 | 4 | 1 | 5 | 1.5 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(F)cc1 | nan | |||
| CHEMBL4762210 | 181392 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 314 | 4 | 1 | 5 | 1.5 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(F)cc1 | nan | |||
| 151392727 | 181829 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 464 | 6 | 1 | 8 | 2.7 | C[C@H](NC(=O)Cn1nc2ccc(N3CCCCC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4777046 | 181829 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 464 | 6 | 1 | 8 | 2.7 | C[C@H](NC(=O)Cn1nc2ccc(N3CCCCC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 134043805 | 181875 | None | 1 | Human | Functional | pEC50 | = | 8 | 8.0 | 3 | 2 | ChEMBL | 362 | 6 | 1 | 6 | 2.0 | CC(NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)cc1 | nan | |||
| CHEMBL4777673 | 181875 | None | 1 | Human | Functional | pEC50 | = | 8 | 8.0 | 3 | 2 | ChEMBL | 362 | 6 | 1 | 6 | 2.0 | CC(NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)cc1 | nan | |||
| 153585533 | 182157 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 372 | 5 | 1 | 5 | 3.0 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(-c2ccccc2)cc1 | nan | |||
| CHEMBL4781160 | 182157 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 372 | 5 | 1 | 5 | 3.0 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(-c2ccccc2)cc1 | nan | |||
| 153585698 | 182527 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 331 | 4 | 1 | 6 | 1.4 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL4785855 | 182527 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 331 | 4 | 1 | 6 | 1.4 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)cc1 | nan | |||
| 149374815 | 182607 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cnccn3c2=O)cc1 | nan | |||
| CHEMBL4786952 | 182607 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cnccn3c2=O)cc1 | nan | |||
| 153585657 | 182676 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 360 | 4 | 1 | 5 | 2.1 | O=C(Cn1nc2ccc(F)cn2c1=O)NC1(c2ccc(Cl)cc2)CC1 | nan | |||
| CHEMBL4787820 | 182676 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 360 | 4 | 1 | 5 | 2.1 | O=C(Cn1nc2ccc(F)cn2c1=O)NC1(c2ccc(Cl)cc2)CC1 | nan | |||
| 121349628 | 182131 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349628 | 182131 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 | nan | |||
| CHEMBL4780801 | 182131 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4780801 | 182131 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 | nan | |||
| 121349739 | 182276 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 392 | 6 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)F)cc1 | nan | |||
| CHEMBL4782619 | 182276 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 392 | 6 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)F)cc1 | nan | |||
| 121349631 | 182588 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | nan | |||
| CHEMBL4786722 | 182588 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | nan | |||
| 122195502 | 124184 | None | 0 | Human | Functional | pEC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 402 | 8 | 2 | 3 | 3.9 | COc1cccc(C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633717 | 124184 | None | 0 | Human | Functional | pEC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 402 | 8 | 2 | 3 | 3.9 | COc1cccc(C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | |||
| 169098787 | 195354 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 359 | 5 | 1 | 5 | 3.1 | CC(C)[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5401884 | 195354 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 359 | 5 | 1 | 5 | 3.1 | CC(C)[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349564 | 181870 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349564 | 181870 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | nan | |||
| CHEMBL4777630 | 181870 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4777630 | 181870 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | nan | |||
| 121349633 | 182823 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | nan | |||
| CHEMBL4789631 | 182823 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | nan | |||
| 164628435 | 186396 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1cccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4874254 | 186396 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1cccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| 169098787 | 195354 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 359 | 5 | 1 | 5 | 3.1 | CC(C)[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5401884 | 195354 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 359 | 5 | 1 | 5 | 3.1 | CC(C)[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098812 | 195915 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 296 | 4 | 1 | 5 | 1.4 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5413318 | 195915 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 296 | 4 | 1 | 5 | 1.4 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098812 | 195915 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 296 | 4 | 1 | 5 | 1.4 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5413318 | 195915 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 296 | 4 | 1 | 5 | 1.4 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 26532940 | 124187 | None | 1 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 316 | 5 | 2 | 2 | 2.9 | C[C@H](NC(=O)CNC(=O)c1ccc(Cl)cc1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633721 | 124187 | None | 1 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 316 | 5 | 2 | 2 | 2.9 | C[C@H](NC(=O)CNC(=O)c1ccc(Cl)cc1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| 164621186 | 186200 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 323 | 4 | 0 | 6 | 2.4 | Cc1ccc([C@H](C)OC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4871591 | 186200 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 323 | 4 | 0 | 6 | 2.4 | Cc1ccc([C@H](C)OC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 169098828 | 195619 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccccc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5407185 | 195619 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccccc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098828 | 195619 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccccc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5407185 | 195619 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccccc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349572 | 181952 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | nan | |||
| CHEMBL4778561 | 181952 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | nan | |||
| 121349566 | 182758 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 372 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 | nan | |||
| CHEMBL4788831 | 182758 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 372 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 | nan | |||
| 121349806 | 183480 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| CHEMBL4797857 | 183480 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| 169098802 | 196973 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 381 | 4 | 1 | 5 | 3.6 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Cl)c(Cl)c1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5435834 | 196973 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 381 | 4 | 1 | 5 | 3.6 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Cl)c(Cl)c1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098802 | 196973 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 381 | 4 | 1 | 5 | 3.6 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Cl)c(Cl)c1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5435834 | 196973 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 381 | 4 | 1 | 5 | 3.6 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Cl)c(Cl)c1 | 10.1021/acs.jmedchem.3c01034 | |||
| 2114212 | 20937 | None | 11 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 308 | 5 | 1 | 5 | 1.2 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccccc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL1310918 | 20937 | None | 11 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 308 | 5 | 1 | 5 | 1.2 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccccc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349764 | 182994 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 360 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(F)cc1Cl | nan | |||
| CHEMBL4792090 | 182994 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 360 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(F)cc1Cl | nan | |||
| 36428174 | 182048 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 376 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4779855 | 182048 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 376 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349734 | 182202 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 | nan | |||
| CHEMBL4781729 | 182202 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 | nan | |||
| 121349683 | 182829 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c12 | nan | |||
| CHEMBL4789720 | 182829 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c12 | nan | |||
| 121349710 | 183054 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | nan | |||
| CHEMBL4792828 | 183054 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | nan | |||
| 121349767 | 183436 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4797410 | 183436 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 2303171 | 124186 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 316 | 5 | 2 | 2 | 2.9 | C[C@H](NC(=O)CNC(=O)c1ccccc1Cl)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633719 | 124186 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 316 | 5 | 2 | 2 | 2.9 | C[C@H](NC(=O)CNC(=O)c1ccccc1Cl)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| 121349643 | 183552 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 404 | 4 | 1 | 5 | 2.6 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(F)cc1Br | nan | |||
| CHEMBL4798899 | 183552 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 404 | 4 | 1 | 5 | 2.6 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(F)cc1Br | nan | |||
| 170222195 | 196983 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 406 | 5 | 1 | 5 | 3.3 | Cc1ccc2cnn(CC(=O)N[C@H](c3ccc(C(F)(F)F)cc3)C(C)C)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5436077 | 196983 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 406 | 5 | 1 | 5 | 3.3 | Cc1ccc2cnn(CC(=O)N[C@H](c3ccc(C(F)(F)F)cc3)C(C)C)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| 164611430 | 185330 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 377 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cn1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4857947 | 185330 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 377 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cn1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349781 | 181954 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 | nan | |||
| CHEMBL4778563 | 181954 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 | nan | |||
| 121349675 | 182071 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 390 | 4 | 1 | 5 | 3.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 | nan | |||
| CHEMBL4780038 | 182071 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 390 | 4 | 1 | 5 | 3.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 | nan | |||
| 121349763 | 182574 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 366 | 5 | 1 | 6 | 2.5 | COc1cc(C)ccc1[C@H](C)NC(=O)[C@@H](C)n1nnc2ccccc2c1=O | nan | |||
| CHEMBL4786501 | 182574 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 366 | 5 | 1 | 6 | 2.5 | COc1cc(C)ccc1[C@H](C)NC(=O)[C@@H](C)n1nnc2ccccc2c1=O | nan | |||
| 121349809 | 183267 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | nan | |||
| CHEMBL4795372 | 183267 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | nan | |||
| 121349689 | 183325 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 372 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | nan | |||
| CHEMBL4796061 | 183325 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 372 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | nan | |||
| 2548547 | 2149 | None | 39 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 316 | 5 | 2 | 2 | 2.9 | O=C(N[C@H](c1ccccc1)C)CNC(=O)c1cccc(c1)Cl | 10.1021/acsmedchemlett.5b00247 | |||
| 8766 | 2149 | None | 39 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 316 | 5 | 2 | 2 | 2.9 | O=C(N[C@H](c1ccccc1)C)CNC(=O)c1cccc(c1)Cl | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633720 | 2149 | None | 39 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 316 | 5 | 2 | 2 | 2.9 | O=C(N[C@H](c1ccccc1)C)CNC(=O)c1cccc(c1)Cl | 10.1021/acsmedchemlett.5b00247 | |||
| 170222195 | 196983 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 406 | 5 | 1 | 5 | 3.3 | Cc1ccc2cnn(CC(=O)N[C@H](c3ccc(C(F)(F)F)cc3)C(C)C)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5436077 | 196983 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 406 | 5 | 1 | 5 | 3.3 | Cc1ccc2cnn(CC(=O)N[C@H](c3ccc(C(F)(F)F)cc3)C(C)C)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| 1555702 | 124185 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 282 | 5 | 2 | 2 | 2.3 | C[C@H](NC(=O)CNC(=O)c1ccccc1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633718 | 124185 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 282 | 5 | 2 | 2 | 2.3 | C[C@H](NC(=O)CNC(=O)c1ccccc1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| 121349597 | 181917 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(Cl)ccc3c2=O)cc1 | nan | |||
| CHEMBL4778124 | 181917 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(Cl)ccc3c2=O)cc1 | nan | |||
| 121349786 | 182359 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 404 | 7 | 1 | 7 | 2.3 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 | nan | |||
| CHEMBL4783626 | 182359 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 404 | 7 | 1 | 7 | 2.3 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 | nan | |||
| 170196135 | 195762 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 327 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2ncc3sccc3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5410300 | 195762 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 327 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2ncc3sccc3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 28918448 | 124206 | None | 2 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 312 | 6 | 2 | 3 | 2.3 | COc1cccc(C(=O)NCC(=O)N[C@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633895 | 124206 | None | 2 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 312 | 6 | 2 | 3 | 2.3 | COc1cccc(C(=O)NCC(=O)N[C@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | |||
| 121349574 | 182925 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349574 | 182925 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 | nan | |||
| CHEMBL4790968 | 182925 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4790968 | 182925 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 | nan | |||
| 121349782 | 183150 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c2c1 | nan | |||
| CHEMBL4794046 | 183150 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c2c1 | nan | |||
| 169098807 | 197094 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 388 | 4 | 1 | 5 | 2.4 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(Br)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5438556 | 197094 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 388 | 4 | 1 | 5 | 2.4 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(Br)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| 170222108 | 196158 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(F)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5417840 | 196158 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(F)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| 170196135 | 195762 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 327 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2ncc3sccc3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5410300 | 195762 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 327 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2ncc3sccc3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349740 | 182197 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | nan | |||
| CHEMBL4781651 | 182197 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | nan | |||
| 121349745 | 182318 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349745 | 182318 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 | nan | |||
| CHEMBL4783071 | 182318 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4783071 | 182318 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 | nan | |||
| 121349593 | 182979 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4791792 | 182979 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F | 10.1021/acs.jmedchem.1c00820 | |||
| 169098813 | 196821 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 324 | 4 | 1 | 5 | 2.0 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccccc3)ncc12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5432850 | 196821 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 324 | 4 | 1 | 5 | 2.0 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccccc3)ncc12 | 10.1021/acs.jmedchem.3c01034 | |||
| 170222108 | 196158 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(F)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5417840 | 196158 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(F)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098813 | 196821 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 324 | 4 | 1 | 5 | 2.0 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccccc3)ncc12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5432850 | 196821 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 324 | 4 | 1 | 5 | 2.0 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccccc3)ncc12 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098809 | 194976 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 324 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2ncc3ccc(C)n3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5394347 | 194976 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 324 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2ncc3ccc(C)n3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098807 | 197094 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 388 | 4 | 1 | 5 | 2.4 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(Br)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5438556 | 197094 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 388 | 4 | 1 | 5 | 2.4 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(Br)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| 40719079 | 124198 | None | 1 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 350 | 5 | 2 | 2 | 3.6 | C[C@H](NC(=O)CNC(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633885 | 124198 | None | 1 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 350 | 5 | 2 | 2 | 3.6 | C[C@H](NC(=O)CNC(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| 121349656 | 183595 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 424 | 5 | 1 | 6 | 2.8 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3F)c(=O)c12 | nan | |||
| CHEMBL4799483 | 183595 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 424 | 5 | 1 | 6 | 2.8 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3F)c(=O)c12 | nan | |||
| 169098809 | 194976 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 324 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2ncc3ccc(C)n3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5394347 | 194976 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 324 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2ncc3ccc(C)n3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098781 | 195441 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 391 | 4 | 1 | 5 | 3.1 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Br)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5403952 | 195441 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 391 | 4 | 1 | 5 | 3.1 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Br)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098781 | 195441 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 391 | 4 | 1 | 5 | 3.1 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Br)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5403952 | 195441 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 391 | 4 | 1 | 5 | 3.1 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Br)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349786 | 182359 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 404 | 7 | 1 | 7 | 2.3 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4783626 | 182359 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 404 | 7 | 1 | 7 | 2.3 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349593 | 182979 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F | nan | |||
| CHEMBL4791792 | 182979 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F | nan | |||
| 2695546 | 186222 | None | 9 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4871792 | 186222 | None | 9 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 169098810 | 195809 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 324 | 5 | 1 | 5 | 2.1 | CC[C@H](NC(=O)Cn1ncc2ccc(C)n2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5411110 | 195809 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 324 | 5 | 1 | 5 | 2.1 | CC[C@H](NC(=O)Cn1ncc2ccc(C)n2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098800 | 196140 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 328 | 4 | 1 | 6 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3sccc3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5417548 | 196140 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 328 | 4 | 1 | 6 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3sccc3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098810 | 195809 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 324 | 5 | 1 | 5 | 2.1 | CC[C@H](NC(=O)Cn1ncc2ccc(C)n2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5411110 | 195809 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 324 | 5 | 1 | 5 | 2.1 | CC[C@H](NC(=O)Cn1ncc2ccc(C)n2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098782 | 195002 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 348 | 4 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nnc2sccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5394715 | 195002 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 348 | 4 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nnc2sccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098837 | 197102 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5438741 | 197102 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| 2548543 | 124207 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 316 | 5 | 2 | 2 | 2.9 | C[C@@H](NC(=O)CNC(=O)c1cccc(Cl)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633896 | 124207 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 316 | 5 | 2 | 2 | 2.9 | C[C@@H](NC(=O)CNC(=O)c1cccc(Cl)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| 11685 | 4139 | None | 28 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 10.1021/acs.jmedchem.1c00820 | |||
| 11685 | 4139 | None | 28 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | nan | |||
| 121349608 | 4139 | None | 28 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349608 | 4139 | None | 28 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | nan | |||
| CHEMBL4779773 | 4139 | None | 28 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4779773 | 4139 | None | 28 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | nan | |||
| 2714485 | 183048 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 326 | 4 | 1 | 5 | 1.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(F)cc1 | nan | |||
| CHEMBL4792727 | 183048 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 326 | 4 | 1 | 5 | 1.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(F)cc1 | nan | |||
| 121349719 | 183365 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349719 | 183365 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 | nan | |||
| CHEMBL4796493 | 183365 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4796493 | 183365 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 | nan | |||
| 8036946 | 183545 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4798779 | 183545 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 169098800 | 196140 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 328 | 4 | 1 | 6 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3sccc3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5417548 | 196140 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 328 | 4 | 1 | 6 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3sccc3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098784 | 196845 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 365 | 4 | 1 | 5 | 3.1 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)cc1Cl | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5433281 | 196845 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 365 | 4 | 1 | 5 | 3.1 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)cc1Cl | 10.1021/acs.jmedchem.3c01034 | |||
| 169098782 | 195002 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 348 | 4 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nnc2sccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5394715 | 195002 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 348 | 4 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nnc2sccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098837 | 197102 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5438741 | 197102 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098785 | 195709 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 347 | 4 | 1 | 5 | 3.0 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5409401 | 195709 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 347 | 4 | 1 | 5 | 3.0 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 16132144 | 211738 | None | 29 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -3388 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acs.jmedchem.3c01034 | |||||
| 16133793 | 211738 | None | 29 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -3388 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acs.jmedchem.3c01034 | |||||
| 44273719 | 211738 | None | 29 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -3388 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acs.jmedchem.3c01034 | |||||
| CHEMBL214332 | 211738 | None | 29 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -3388 | 8 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/acs.jmedchem.3c01034 | |||||
| 169098784 | 196845 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 365 | 4 | 1 | 5 | 3.1 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)cc1Cl | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5433281 | 196845 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 365 | 4 | 1 | 5 | 3.1 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)cc1Cl | 10.1021/acs.jmedchem.3c01034 | |||
| 170222155 | 196793 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2ncc3ccc(C)n3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5432364 | 196793 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2ncc3ccc(C)n3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349614 | 181771 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(C)c1 | nan | |||
| CHEMBL4776329 | 181771 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(C)c1 | nan | |||
| 27783537 | 181789 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 386 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 | nan | |||
| CHEMBL4776509 | 181789 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 386 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 | nan | |||
| 121349728 | 181922 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349728 | 181922 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 | nan | |||
| CHEMBL4778172 | 181922 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4778172 | 181922 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 | nan | |||
| 41757362 | 182319 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 352 | 6 | 1 | 6 | 2.1 | CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | |||
| CHEMBL4783081 | 182319 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 352 | 6 | 1 | 6 | 2.1 | CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | |||
| 121349658 | 182809 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4789475 | 182809 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| 27785340 | 183577 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4799237 | 183577 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | 10.1021/acs.jmedchem.1c00820 | |||
| 27754276 | 186037 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 336 | 5 | 1 | 5 | 2.4 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4869182 | 186037 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 336 | 5 | 1 | 5 | 2.4 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 7534868 | 124191 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 296 | 5 | 2 | 2 | 2.6 | Cc1cccc(C(=O)NCC(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633878 | 124191 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 296 | 5 | 2 | 2 | 2.6 | Cc1cccc(C(=O)NCC(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | |||
| 122195644 | 124201 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 334 | 5 | 2 | 2 | 3.1 | C[C@H](NC(=O)CNC(=O)c1cc(F)cc(Cl)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633888 | 124201 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 334 | 5 | 2 | 2 | 3.1 | C[C@H](NC(=O)CNC(=O)c1cc(F)cc(Cl)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| 169098785 | 195709 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 347 | 4 | 1 | 5 | 3.0 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5409401 | 195709 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 347 | 4 | 1 | 5 | 3.0 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 170222155 | 196793 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2ncc3ccc(C)n3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5432364 | 196793 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2ncc3ccc(C)n3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098799 | 196535 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 349 | 4 | 1 | 5 | 2.6 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)c(F)c1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5426183 | 196535 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 349 | 4 | 1 | 5 | 2.6 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)c(F)c1 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349701 | 182050 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc12 | nan | |||
| CHEMBL4779884 | 182050 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc12 | nan | |||
| 169098799 | 196535 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 349 | 4 | 1 | 5 | 2.6 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)c(F)c1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5426183 | 196535 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 349 | 4 | 1 | 5 | 2.6 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)c(F)c1 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349805 | 183226 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(OC)c3c2=O)cc1 | nan | |||
| CHEMBL4794908 | 183226 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(OC)c3c2=O)cc1 | nan | |||
| 170196143 | 195887 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 338 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(C#N)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5412645 | 195887 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 338 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(C#N)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349755 | 181909 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 | nan | |||
| CHEMBL4778062 | 181909 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 | nan | |||
| 121349734 | 182202 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4781729 | 182202 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| 27785340 | 183577 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | nan | |||
| CHEMBL4799237 | 183577 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | nan | |||
| 172442141 | 195224 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 363 | 4 | 1 | 5 | 3.5 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1cccc2ccccc12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5399140 | 195224 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 363 | 4 | 1 | 5 | 3.5 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1cccc2ccccc12 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098829 | 195398 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2ncc3cccn3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5402898 | 195398 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2ncc3cccn3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098789 | 196290 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 349 | 4 | 1 | 5 | 2.6 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)cc1F | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5420577 | 196290 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 349 | 4 | 1 | 5 | 2.6 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)cc1F | 10.1021/acs.jmedchem.3c01034 | |||
| 170222160 | 196341 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 346 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1cccc2ccccc12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5421824 | 196341 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 346 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1cccc2ccccc12 | 10.1021/acs.jmedchem.3c01034 | |||
| 170196143 | 195887 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 338 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(C#N)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5412645 | 195887 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 338 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(C#N)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098789 | 196290 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 349 | 4 | 1 | 5 | 2.6 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)cc1F | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5420577 | 196290 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 349 | 4 | 1 | 5 | 2.6 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)cc1F | 10.1021/acs.jmedchem.3c01034 | |||
| 169098806 | 195162 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 330 | 4 | 1 | 5 | 2.0 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5397779 | 195162 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 330 | 4 | 1 | 5 | 2.0 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098801 | 195589 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 381 | 4 | 1 | 5 | 3.4 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5406603 | 195589 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 381 | 4 | 1 | 5 | 3.4 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098829 | 195398 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2ncc3cccn3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5402898 | 195398 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2ncc3cccn3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 172442141 | 195224 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 363 | 4 | 1 | 5 | 3.5 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1cccc2ccccc12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5399140 | 195224 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 363 | 4 | 1 | 5 | 3.5 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1cccc2ccccc12 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098801 | 195589 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 381 | 4 | 1 | 5 | 3.4 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5406603 | 195589 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 381 | 4 | 1 | 5 | 3.4 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 122195501 | 124183 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 342 | 7 | 3 | 4 | 1.7 | COc1cccc(C(=O)N[C@@H](CO)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633716 | 124183 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 342 | 7 | 3 | 4 | 1.7 | COc1cccc(C(=O)N[C@@H](CO)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | |||
| 8036887 | 184846 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 322 | 5 | 1 | 5 | 1.7 | C[C@@H](CNC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4850747 | 184846 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 322 | 5 | 1 | 5 | 1.7 | C[C@@H](CNC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349639 | 182523 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F | 10.1021/acs.jmedchem.1c00820 | |||
| 121349639 | 182523 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F | nan | |||
| CHEMBL4785741 | 182523 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4785741 | 182523 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F | nan | |||
| 170222160 | 196341 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 346 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1cccc2ccccc12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5421824 | 196341 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 346 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1cccc2ccccc12 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098806 | 195162 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 330 | 4 | 1 | 5 | 2.0 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5397779 | 195162 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 330 | 4 | 1 | 5 | 2.0 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 3341369 | 47659 | None | 5 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCc1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL1546963 | 47659 | None | 5 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCc1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349694 | 182321 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349694 | 182321 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 | nan | |||
| CHEMBL4783106 | 182321 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4783106 | 182321 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 | nan | |||
| 121349596 | 183547 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4798863 | 183547 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 164609046 | 184591 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.5 | Cc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4847108 | 184591 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.5 | Cc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349780 | 186475 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 322 | 5 | 1 | 5 | 1.5 | Cc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4875522 | 186475 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 322 | 5 | 1 | 5 | 1.5 | Cc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 169098834 | 196189 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 356 | 5 | 1 | 5 | 2.5 | Cc1ccc2cnn(CC(=O)N[C@H](c3ccc(F)cc3)C(C)C)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5418368 | 196189 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 356 | 5 | 1 | 5 | 2.5 | Cc1ccc2cnn(CC(=O)N[C@H](c3ccc(F)cc3)C(C)C)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349738 | 182203 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 390 | 5 | 1 | 5 | 3.1 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| CHEMBL4781754 | 182203 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 390 | 5 | 1 | 5 | 3.1 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| 169098834 | 196189 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 356 | 5 | 1 | 5 | 2.5 | Cc1ccc2cnn(CC(=O)N[C@H](c3ccc(F)cc3)C(C)C)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5418368 | 196189 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 356 | 5 | 1 | 5 | 2.5 | Cc1ccc2cnn(CC(=O)N[C@H](c3ccc(F)cc3)C(C)C)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| 170222162 | 196320 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 374 | 4 | 1 | 5 | 2.1 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(Br)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5421380 | 196320 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 374 | 4 | 1 | 5 | 2.1 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(Br)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 170222162 | 196320 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 374 | 4 | 1 | 5 | 2.1 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(Br)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5421380 | 196320 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 374 | 4 | 1 | 5 | 2.1 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(Br)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349572 | 181952 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4778561 | 181952 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 2109722 | 124203 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 342 | 7 | 2 | 4 | 2.3 | COc1cc(OC)cc(C(=O)NCC(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633890 | 124203 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 342 | 7 | 2 | 4 | 2.3 | COc1cc(OC)cc(C(=O)NCC(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | |||
| 170196141 | 196224 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 314 | 4 | 1 | 6 | 1.7 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccccn1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5419310 | 196224 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 314 | 4 | 1 | 6 | 1.7 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccccn1 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349658 | 182809 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 | nan | |||
| CHEMBL4789475 | 182809 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 | nan | |||
| 121349548 | 183535 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 338 | 5 | 1 | 6 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4798667 | 183535 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 338 | 5 | 1 | 6 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 8036946 | 183545 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL4798779 | 183545 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | nan | |||
| 26810968 | 186389 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 358 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1cccc2ccccc12 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4874147 | 186389 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 358 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1cccc2ccccc12 | 10.1021/acs.jmedchem.1c00820 | |||
| 28918445 | 124194 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 312 | 6 | 2 | 3 | 2.3 | COc1cccc(C(=O)NCC(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633881 | 124194 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 312 | 6 | 2 | 3 | 2.3 | COc1cccc(C(=O)NCC(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | |||
| 169098838 | 195403 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 354 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2ncc3c(C)cc(C)n3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5403066 | 195403 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 354 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2ncc3c(C)cc(C)n3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 170196141 | 196224 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 314 | 4 | 1 | 6 | 1.7 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccccn1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5419310 | 196224 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 314 | 4 | 1 | 6 | 1.7 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccccn1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098838 | 195403 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 354 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2ncc3c(C)cc(C)n3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5403066 | 195403 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 354 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2ncc3c(C)cc(C)n3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 172470545 | 197063 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 381 | 4 | 1 | 5 | 3.6 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Cl)cc1Cl | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5437907 | 197063 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 381 | 4 | 1 | 5 | 3.6 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Cl)cc1Cl | 10.1021/acs.jmedchem.3c01034 | |||
| 172470545 | 197063 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 381 | 4 | 1 | 5 | 3.6 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Cl)cc1Cl | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5437907 | 197063 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 381 | 4 | 1 | 5 | 3.6 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Cl)cc1Cl | 10.1021/acs.jmedchem.3c01034 | |||
| 121349633 | 182823 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4789631 | 182823 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | 10.1021/acs.jmedchem.1c00820 | |||
| 121349767 | 183436 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 | nan | |||
| CHEMBL4797410 | 183436 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 | nan | |||
| 121349559 | 181942 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc2c1 | nan | |||
| CHEMBL4778354 | 181942 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc2c1 | nan | |||
| 121349615 | 183231 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 366 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 | nan | |||
| CHEMBL4795005 | 183231 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 366 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 | nan | |||
| 121349746 | 183490 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 390 | 4 | 1 | 5 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4797979 | 183490 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 390 | 4 | 1 | 5 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349645 | 181824 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4776988 | 181824 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 121349720 | 182349 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(OC)cccc3c2=O)cc1 | nan | |||
| CHEMBL4783544 | 182349 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(OC)cccc3c2=O)cc1 | nan | |||
| 122195642 | 124199 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 350 | 5 | 2 | 2 | 3.6 | C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633886 | 124199 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 350 | 5 | 2 | 2 | 3.6 | C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| 121349688 | 183004 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 | nan | |||
| CHEMBL4792174 | 183004 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 | nan | |||
| 169098788 | 196753 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 331 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5431491 | 196753 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 331 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349659 | 182371 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 | nan | |||
| CHEMBL4783774 | 182371 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 | nan | |||
| 169098788 | 196753 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 331 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5431491 | 196753 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 331 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349600 | 182691 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c2c1 | nan | |||
| CHEMBL4788013 | 182691 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c2c1 | nan | |||
| 3376937 | 124204 | None | 45 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 70 | 2 | ChEMBL | 365 | 4 | 3 | 4 | 3.3 | COc1cc(OC)cc(C(=O)NNC(=O)Nc2cccc3ccccc23)c1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633893 | 124204 | None | 45 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 70 | 2 | ChEMBL | 365 | 4 | 3 | 4 | 3.3 | COc1cc(OC)cc(C(=O)NNC(=O)Nc2cccc3ccccc23)c1 | 10.1021/acsmedchemlett.5b00247 | |||
| 170222165 | 195018 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 360 | 4 | 1 | 5 | 2.8 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3cccc4ccccc34)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5395065 | 195018 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 360 | 4 | 1 | 5 | 2.8 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3cccc4ccccc34)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| 122195500 | 124182 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 326 | 6 | 2 | 3 | 2.7 | COc1cccc(C(=O)N[C@H](C)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633715 | 124182 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 326 | 6 | 2 | 3 | 2.7 | COc1cccc(C(=O)N[C@H](C)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | |||
| 121349746 | 183490 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 390 | 4 | 1 | 5 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | nan | |||
| CHEMBL4797979 | 183490 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 390 | 4 | 1 | 5 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | nan | |||
| 170222165 | 195018 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 360 | 4 | 1 | 5 | 2.8 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3cccc4ccccc34)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5395065 | 195018 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 360 | 4 | 1 | 5 | 2.8 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3cccc4ccccc34)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| 2496250 | 28960 | None | 4 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 338 | 6 | 1 | 6 | 1.2 | COc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL1380104 | 28960 | None | 4 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 338 | 6 | 1 | 6 | 1.2 | COc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 122195640 | 124196 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 366 | 6 | 2 | 3 | 3.2 | C[C@H](NC(=O)CNC(=O)c1cccc(OC(F)(F)F)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633883 | 124196 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 366 | 6 | 2 | 3 | 3.2 | C[C@H](NC(=O)CNC(=O)c1cccc(OC(F)(F)F)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| 122195643 | 124200 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 350 | 5 | 2 | 2 | 3.6 | C[C@H](NC(=O)CNC(=O)c1cc(Cl)cc(Cl)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633887 | 124200 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 350 | 5 | 2 | 2 | 3.6 | C[C@H](NC(=O)CNC(=O)c1cc(Cl)cc(Cl)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| 169098803 | 196866 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 344 | 5 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3sccc3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5433669 | 196866 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 344 | 5 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3sccc3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 170196155 | 197082 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 398 | 5 | 1 | 7 | 2.6 | C[C@H](NC(=O)Cn1nnc2sccc2c1=O)c1ccc(OC(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5438241 | 197082 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 398 | 5 | 1 | 7 | 2.6 | C[C@H](NC(=O)Cn1nnc2sccc2c1=O)c1ccc(OC(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098803 | 196866 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 344 | 5 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3sccc3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5433669 | 196866 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 344 | 5 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3sccc3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098815 | 196204 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 310 | 5 | 1 | 5 | 1.8 | CC[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5418797 | 196204 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 310 | 5 | 1 | 5 | 1.8 | CC[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349558 | 182078 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 428 | 5 | 1 | 6 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1F | nan | |||
| CHEMBL4780121 | 182078 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 428 | 5 | 1 | 6 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1F | nan | |||
| 121349685 | 182239 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 440 | 6 | 1 | 7 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 | nan | |||
| CHEMBL4782204 | 182239 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 440 | 6 | 1 | 7 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 | nan | |||
| 169098815 | 196204 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 310 | 5 | 1 | 5 | 1.8 | CC[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5418797 | 196204 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 310 | 5 | 1 | 5 | 1.8 | CC[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349623 | 182206 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc12 | nan | |||
| CHEMBL4781805 | 182206 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc12 | nan | |||
| 121349588 | 182342 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 406 | 6 | 1 | 6 | 3.0 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4783365 | 182342 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 406 | 6 | 1 | 6 | 3.0 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 170196155 | 197082 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 398 | 5 | 1 | 7 | 2.6 | C[C@H](NC(=O)Cn1nnc2sccc2c1=O)c1ccc(OC(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5438241 | 197082 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 398 | 5 | 1 | 7 | 2.6 | C[C@H](NC(=O)Cn1nnc2sccc2c1=O)c1ccc(OC(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349773 | 182534 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc2c1 | nan | |||
| CHEMBL4785980 | 182534 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc2c1 | nan | |||
| 169098791 | 194967 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 343 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2ncc3sccc3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5394251 | 194967 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 343 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2ncc3sccc3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349793 | 181929 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 366 | 5 | 1 | 6 | 2.5 | COc1cc(C)ccc1[C@H](C)NC(=O)[C@H](C)n1nnc2ccccc2c1=O | nan | |||
| CHEMBL4778263 | 181929 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 366 | 5 | 1 | 6 | 2.5 | COc1cc(C)ccc1[C@H](C)NC(=O)[C@H](C)n1nnc2ccccc2c1=O | nan | |||
| 122195639 | 124195 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 350 | 5 | 2 | 2 | 3.3 | C[C@H](NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633882 | 124195 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 350 | 5 | 2 | 2 | 3.3 | C[C@H](NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| 122195641 | 124197 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 350 | 5 | 2 | 2 | 3.6 | C[C@H](NC(=O)CNC(=O)c1cccc(Cl)c1Cl)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633884 | 124197 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 350 | 5 | 2 | 2 | 3.6 | C[C@H](NC(=O)CNC(=O)c1cccc(Cl)c1Cl)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| 169098798 | 196930 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 327 | 5 | 1 | 5 | 2.7 | CC[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5435044 | 196930 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 327 | 5 | 1 | 5 | 2.7 | CC[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098791 | 194967 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 343 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2ncc3sccc3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5394251 | 194967 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 343 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2ncc3sccc3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098798 | 196930 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 327 | 5 | 1 | 5 | 2.7 | CC[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5435044 | 196930 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 327 | 5 | 1 | 5 | 2.7 | CC[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098820 | 194993 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 358 | 4 | 1 | 5 | 2.6 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)ncc12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5394567 | 194993 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 358 | 4 | 1 | 5 | 2.6 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)ncc12 | 10.1021/acs.jmedchem.3c01034 | |||
| 2714528 | 182584 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 308 | 4 | 1 | 5 | 1.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | nan | |||
| CHEMBL4786641 | 182584 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 308 | 4 | 1 | 5 | 1.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | nan | |||
| 2714527 | 185511 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 308 | 4 | 1 | 5 | 1.7 | C[C@@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4861019 | 185511 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 308 | 4 | 1 | 5 | 1.7 | C[C@@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349679 | 186374 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 352 | 6 | 1 | 6 | 1.5 | COc1ccc(C[C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4873905 | 186374 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 352 | 6 | 1 | 6 | 1.5 | COc1ccc(C[C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 28821961 | 124193 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 300 | 5 | 2 | 2 | 2.4 | C[C@H](NC(=O)CNC(=O)c1cccc(F)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633880 | 124193 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 300 | 5 | 2 | 2 | 2.4 | C[C@H](NC(=O)CNC(=O)c1cccc(F)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| 169098779 | 195654 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 313 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5408151 | 195654 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 313 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 170222105 | 195139 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 314 | 4 | 1 | 5 | 1.5 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5397321 | 195139 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 314 | 4 | 1 | 5 | 1.5 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098779 | 195654 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 313 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5408151 | 195654 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 313 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098811 | 196618 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 364 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5427962 | 196618 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 364 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098820 | 194993 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 358 | 4 | 1 | 5 | 2.6 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)ncc12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5394567 | 194993 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 358 | 4 | 1 | 5 | 2.6 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)ncc12 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098811 | 196618 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 364 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5427962 | 196618 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 364 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098818 | 196662 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 378 | 4 | 1 | 5 | 2.7 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5429215 | 196662 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 378 | 4 | 1 | 5 | 2.7 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098792 | 196964 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 332 | 4 | 1 | 6 | 1.9 | C[C@H](NC(=O)Cn1nnc2sccc2c1=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5435655 | 196964 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 332 | 4 | 1 | 6 | 1.9 | C[C@H](NC(=O)Cn1nnc2sccc2c1=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 170222105 | 195139 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 314 | 4 | 1 | 5 | 1.5 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5397321 | 195139 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 314 | 4 | 1 | 5 | 1.5 | C[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098792 | 196964 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 332 | 4 | 1 | 6 | 1.9 | C[C@H](NC(=O)Cn1nnc2sccc2c1=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5435655 | 196964 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 332 | 4 | 1 | 6 | 1.9 | C[C@H](NC(=O)Cn1nnc2sccc2c1=O)c1ccc(F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349685 | 182239 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 440 | 6 | 1 | 7 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4782204 | 182239 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 440 | 6 | 1 | 7 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | |||
| 169098818 | 196662 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 378 | 4 | 1 | 5 | 2.7 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5429215 | 196662 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 378 | 4 | 1 | 5 | 2.7 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098823 | 196111 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 326 | 5 | 1 | 6 | 1.4 | COc1ccc([C@H](C)NC(=O)Cn2ncc3cccn3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5417091 | 196111 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 326 | 5 | 1 | 6 | 1.4 | COc1ccc([C@H](C)NC(=O)Cn2ncc3cccn3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098835 | 196233 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 324 | 5 | 1 | 5 | 2.0 | CC(C)[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5419423 | 196233 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 324 | 5 | 1 | 5 | 2.0 | CC(C)[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 122195638 | 124192 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 307 | 5 | 2 | 3 | 2.2 | C[C@H](NC(=O)CNC(=O)c1cccc(C#N)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633879 | 124192 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 307 | 5 | 2 | 3 | 2.2 | C[C@H](NC(=O)CNC(=O)c1cccc(C#N)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| 169098823 | 196111 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 326 | 5 | 1 | 6 | 1.4 | COc1ccc([C@H](C)NC(=O)Cn2ncc3cccn3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5417091 | 196111 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 326 | 5 | 1 | 6 | 1.4 | COc1ccc([C@H](C)NC(=O)Cn2ncc3cccn3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098835 | 196233 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 324 | 5 | 1 | 5 | 2.0 | CC(C)[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5419423 | 196233 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 324 | 5 | 1 | 5 | 2.0 | CC(C)[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349795 | 183555 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 | nan | |||
| CHEMBL4798933 | 183555 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 | nan | |||
| 27838947 | 185537 | None | 1 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1cccc(Cl)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4861445 | 185537 | None | 1 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1cccc(Cl)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| 2998350 | 38115 | None | 4 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 334 | 3 | 1 | 5 | 2.0 | O=C(Cn1nnc2ccccc2c1=O)NC1CCCc2ccccc21 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL1460960 | 38115 | None | 4 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 334 | 3 | 1 | 5 | 2.0 | O=C(Cn1nnc2ccccc2c1=O)NC1CCCc2ccccc21 | 10.1021/acs.jmedchem.1c00820 | |||
| 122195499 | 124181 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 326 | 6 | 2 | 3 | 2.7 | COc1cccc(C(=O)N[C@@H](C)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633714 | 124181 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 326 | 6 | 2 | 3 | 2.7 | COc1cccc(C(=O)N[C@@H](C)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | |||
| 41757362 | 182319 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 352 | 6 | 1 | 6 | 2.1 | CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4783081 | 182319 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 352 | 6 | 1 | 6 | 2.1 | CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349753 | 183000 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 | nan | |||
| CHEMBL4792136 | 183000 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 | nan | |||
| 2856847 | 124205 | None | 7 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 299 | 5 | 1 | 3 | 3.4 | CC(NC(=O)CSC(=O)c1ccccc1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633894 | 124205 | None | 7 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 299 | 5 | 1 | 3 | 3.4 | CC(NC(=O)CSC(=O)c1ccccc1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| 164619649 | 185872 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccccc1Cl | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4866435 | 185872 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccccc1Cl | 10.1021/acs.jmedchem.1c00820 | |||
| 169098797 | 195084 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 341 | 5 | 1 | 5 | 3.0 | CC(C)[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5396468 | 195084 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 341 | 5 | 1 | 5 | 3.0 | CC(C)[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098797 | 195084 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 341 | 5 | 1 | 5 | 3.0 | CC(C)[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5396468 | 195084 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 341 | 5 | 1 | 5 | 3.0 | CC(C)[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 121349671 | 181859 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 350 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 | nan | |||
| CHEMBL4777495 | 181859 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 350 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 | nan | |||
| 121349778 | 182462 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 3.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 | nan | |||
| CHEMBL4784744 | 182462 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 3.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 | nan | |||
| 121349756 | 182673 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 | nan | |||
| CHEMBL4787761 | 182673 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 | nan | |||
| 121349555 | 182743 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | |||
| CHEMBL4788631 | 182743 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | |||
| 121349787 | 182778 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 | nan | |||
| CHEMBL4789079 | 182778 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 | nan | |||
| 121349554 | 183645 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(OC)ccc3c2=O)cc1 | nan | |||
| CHEMBL4800089 | 183645 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(OC)ccc3c2=O)cc1 | nan | |||
| 164617704 | 184637 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 374 | 6 | 1 | 7 | 1.4 | COc1ccc([C@H](C)NS(=O)(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4847795 | 184637 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 374 | 6 | 1 | 7 | 1.4 | COc1ccc([C@H](C)NS(=O)(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 170196145 | 195721 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 409 | 5 | 1 | 5 | 4.0 | CC(C)[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5409522 | 195721 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 409 | 5 | 1 | 5 | 4.0 | CC(C)[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098819 | 195048 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 394 | 5 | 1 | 6 | 2.6 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5395516 | 195048 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 394 | 5 | 1 | 6 | 2.6 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098819 | 195048 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 394 | 5 | 1 | 6 | 2.6 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5395516 | 195048 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 394 | 5 | 1 | 6 | 2.6 | Cc1ccc2cnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 | 10.1021/acs.jmedchem.3c01034 | |||
| 164617980 | 185135 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 377 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)nc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4855076 | 185135 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 377 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)nc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 170196145 | 195721 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 409 | 5 | 1 | 5 | 4.0 | CC(C)[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5409522 | 195721 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 409 | 5 | 1 | 5 | 4.0 | CC(C)[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 122195645 | 124202 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 394 | 5 | 2 | 2 | 3.7 | C[C@H](NC(=O)CNC(=O)c1cc(Cl)cc(Br)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| CHEMBL3633889 | 124202 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 394 | 5 | 2 | 2 | 3.7 | C[C@H](NC(=O)CNC(=O)c1cc(Cl)cc(Br)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | |||
| 78596259 | 185481 | None | 1 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | CC(NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4860510 | 185481 | None | 1 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | CC(NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349587 | 182518 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 | nan | |||
| CHEMBL4785669 | 182518 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 | nan | |||
| 169098783 | 195342 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 365 | 4 | 1 | 5 | 3.1 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Cl)c(F)c1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5401670 | 195342 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 365 | 4 | 1 | 5 | 3.1 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Cl)c(F)c1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098783 | 195342 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 365 | 4 | 1 | 5 | 3.1 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Cl)c(F)c1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5401670 | 195342 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 365 | 4 | 1 | 5 | 3.1 | C[C@H](NC(=O)Cn1ncc2sccc2c1=O)c1ccc(Cl)c(F)c1 | 10.1021/acs.jmedchem.3c01034 | |||
| 170222172 | 196314 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 392 | 5 | 1 | 5 | 3.0 | CC(C)[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5421234 | 196314 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 392 | 5 | 1 | 5 | 3.0 | CC(C)[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 170222172 | 196314 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 392 | 5 | 1 | 5 | 3.0 | CC(C)[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5421234 | 196314 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 392 | 5 | 1 | 5 | 3.0 | CC(C)[C@H](NC(=O)Cn1ncc2cccn2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 164620660 | 186051 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 384 | 6 | 1 | 5 | 2.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccc(-c2ccccc2)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4869485 | 186051 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 384 | 6 | 1 | 5 | 2.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccc(-c2ccccc2)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 169098832 | 195239 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 338 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2ncc3c(C)cc(C)n3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5399292 | 195239 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 338 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2ncc3c(C)cc(C)n3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 27783537 | 181789 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 386 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4776509 | 181789 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 386 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349569 | 182021 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 | nan | |||
| CHEMBL4779481 | 182021 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 | nan | |||
| 121349561 | 182836 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 | nan | |||
| CHEMBL4789791 | 182836 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 | nan | |||
| 121349769 | 183033 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 | nan | |||
| CHEMBL4792561 | 183033 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 | nan | |||
| 121349596 | 183547 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | |||
| CHEMBL4798863 | 183547 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | |||
| 164620725 | 186191 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.2 | COc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4871506 | 186191 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.2 | COc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 36428174 | 182048 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 376 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| CHEMBL4779855 | 182048 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 376 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| 121349753 | 183000 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4792136 | 183000 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| 169098832 | 195239 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 338 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2ncc3c(C)cc(C)n3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5399292 | 195239 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 338 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2ncc3c(C)cc(C)n3c2=O)cc1 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098816 | 195493 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 408 | 5 | 1 | 6 | 2.9 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)ncc12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5404791 | 195493 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 408 | 5 | 1 | 6 | 2.9 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)ncc12 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098817 | 195837 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 342 | 4 | 1 | 5 | 2.1 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(F)cc3)ncc12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5411677 | 195837 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 342 | 4 | 1 | 5 | 2.1 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(F)cc3)ncc12 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098817 | 195837 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 342 | 4 | 1 | 5 | 2.1 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(F)cc3)ncc12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5411677 | 195837 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 342 | 4 | 1 | 5 | 2.1 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(F)cc3)ncc12 | 10.1021/acs.jmedchem.3c01034 | |||
| 169098816 | 195493 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 408 | 5 | 1 | 6 | 2.9 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)ncc12 | 10.1021/acs.jmedchem.3c01034 | |||
| CHEMBL5404791 | 195493 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 408 | 5 | 1 | 6 | 2.9 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)ncc12 | 10.1021/acs.jmedchem.3c01034 | |||
| 11685 | 4139 | None | 28 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | Guide to Pharmacology | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 34260228 | |||
| 121349608 | 4139 | None | 28 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | Guide to Pharmacology | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 34260228 | |||
| CHEMBL4779773 | 4139 | None | 28 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | Guide to Pharmacology | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 34260228 | |||
| 2144 | 2356 | None | 0 | Human | Functional | pEC50 | = | 3.5 | 3.5 | - | 1 | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 24826842 | |||
| 3313 | 2356 | None | 0 | Human | Functional | pEC50 | = | 3.5 | 3.5 | - | 1 | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 24826842 | |||
| 6140 | 2356 | None | 0 | Human | Functional | pEC50 | = | 3.5 | 3.5 | - | 1 | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 24826842 | |||
| 6925665 | 2356 | None | 0 | Human | Functional | pEC50 | = | 3.5 | 3.5 | - | 1 | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 24826842 | |||
| CHEMBL301523 | 2356 | None | 0 | Human | Functional | pEC50 | = | 3.5 | 3.5 | - | 1 | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 24826842 | |||
| DB00120 | 2356 | None | 0 | Human | Functional | pEC50 | = | 3.5 | 3.5 | - | 1 | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 24826842 | |||
| 2780 | 2373 | None | 60 | Human | Functional | pEC50 | = | 3.7 | 3.7 | 13 | 2 | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 24826842 | |||
| 6305 | 2373 | None | 60 | Human | Functional | pEC50 | = | 3.7 | 3.7 | 13 | 2 | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 24826842 | |||
| 6923516 | 2373 | None | 60 | Human | Functional | pEC50 | = | 3.7 | 3.7 | 13 | 2 | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 24826842 | |||
| 717 | 2373 | None | 60 | Human | Functional | pEC50 | = | 3.7 | 3.7 | 13 | 2 | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 24826842 | |||
| CHEMBL54976 | 2373 | None | 60 | Human | Functional | pEC50 | = | 3.7 | 3.7 | 13 | 2 | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 24826842 | |||
| DB00150 | 2373 | None | 60 | Human | Functional | pEC50 | = | 3.7 | 3.7 | 13 | 2 | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 24826842 | |||
| 7799 | 1011 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | Guide to Pharmacology | 365 | 4 | 3 | 4 | 3.3 | COc1cc(OC)cc(c1)C(=O)NNC(=O)Nc1ccc2c(c1)cccc2 | 24900311 | |||
| 86277840 | 1011 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | Guide to Pharmacology | 365 | 4 | 3 | 4 | 3.3 | COc1cc(OC)cc(c1)C(=O)NNC(=O)Nc1ccc2c(c1)cccc2 | 24900311 | |||
| 2144 | 2356 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | Drug Central | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | None | |||
| 3313 | 2356 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | Drug Central | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | None | |||
| 6140 | 2356 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | Drug Central | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | None | |||
| 6925665 | 2356 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | Drug Central | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | None | |||
| CHEMBL301523 | 2356 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | Drug Central | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | None | |||
| DB00120 | 2356 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | Drug Central | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | None | |||
| 2780 | 2373 | None | 60 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 13 | 2 | Drug Central | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | None | |||
| 6305 | 2373 | None | 60 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 13 | 2 | Drug Central | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | None | |||
| 6923516 | 2373 | None | 60 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 13 | 2 | Drug Central | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | None | |||
| 717 | 2373 | None | 60 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 13 | 2 | Drug Central | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | None | |||
| CHEMBL54976 | 2373 | None | 60 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 13 | 2 | Drug Central | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | None | |||
| DB00150 | 2373 | None | 60 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 13 | 2 | Drug Central | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | None | |||
| 12363 | 2751 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | Guide to Pharmacology | 340 | 1 | 1 | 3 | 4.8 | Oc1cc2c(cc1)c(=O)c(c1ccc(Cl)cc1)c(o2)C(F)(F)F | 36736525 | |||
| 5348723 | 2751 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | Guide to Pharmacology | 340 | 1 | 1 | 3 | 4.8 | Oc1cc2c(cc1)c(=O)c(c1ccc(Cl)cc1)c(o2)C(F)(F)F | 36736525 | |||
| 2144 | 2356 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | |||
| 3313 | 2356 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | |||
| 6140 | 2356 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | |||
| 6925665 | 2356 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | |||
| CHEMBL301523 | 2356 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | |||
| DB00120 | 2356 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | |||
| 2780 | 2373 | None | 60 | Human | Functional | pIC50 | = | 4.6 | 4.6 | 13 | 2 | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | |||
| 6305 | 2373 | None | 60 | Human | Functional | pIC50 | = | 4.6 | 4.6 | 13 | 2 | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | |||
| 6923516 | 2373 | None | 60 | Human | Functional | pIC50 | = | 4.6 | 4.6 | 13 | 2 | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | |||
| 717 | 2373 | None | 60 | Human | Functional | pIC50 | = | 4.6 | 4.6 | 13 | 2 | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | |||
| CHEMBL54976 | 2373 | None | 60 | Human | Functional | pIC50 | = | 4.6 | 4.6 | 13 | 2 | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | |||
| DB00150 | 2373 | None | 60 | Human | Functional | pIC50 | = | 4.6 | 4.6 | 13 | 2 | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | |||
| 789353 | 2354 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | Guide to Pharmacology | 329 | 4 | 1 | 2 | 4.8 | Cc1ccccc1NS(=O)(=O)c1ccc(cc1)C1CCCCC1 | 19525486 | |||
| 8774 | 2354 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | Guide to Pharmacology | 329 | 4 | 1 | 2 | 4.8 | Cc1ccccc1NS(=O)(=O)c1ccc(cc1)C1CCCCC1 | 19525486 | |||
| 5017692 | 2750 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | Guide to Pharmacology | 289 | 3 | 0 | 2 | 3.4 | COc1ccc(cc1)C1N(c2ccccc2)C(=O)C1(F)F | 26027661 | |||
| 8775 | 2750 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | Guide to Pharmacology | 289 | 3 | 0 | 2 | 3.4 | COc1ccc(cc1)C1N(c2ccccc2)C(=O)C1(F)F | 26027661 | |||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 153585580 | 179550 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 411 | 6 | 1 | 8 | 1.7 | COc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | |||
| CHEMBL4740491 | 179550 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 411 | 6 | 1 | 8 | 1.7 | COc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | |||
| 148397968 | 179741 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | |||
| CHEMBL4742901 | 179741 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | |||
| 153585666 | 179743 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 378 | 5 | 1 | 6 | 2.2 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | |||
| CHEMBL4742949 | 179743 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 378 | 5 | 1 | 6 | 2.2 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | |||
| 147451915 | 179793 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 348 | 4 | 1 | 5 | 2.2 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4743612 | 179793 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 348 | 4 | 1 | 5 | 2.2 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585625 | 179799 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 324 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(C)ccn3c2=O)cc1 | nan | |||
| CHEMBL4743662 | 179799 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 324 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(C)ccn3c2=O)cc1 | nan | |||
| 153585420 | 179916 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 364 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | |||
| CHEMBL4744927 | 179916 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 364 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | |||
| 153585722 | 180053 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 394 | 5 | 1 | 6 | 2.6 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | |||
| CHEMBL4746401 | 180053 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 394 | 5 | 1 | 6 | 2.6 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | |||
| 162649907 | 180189 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 378 | 5 | 2 | 7 | 1.6 | CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | |||
| CHEMBL4748076 | 180189 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 378 | 5 | 2 | 7 | 1.6 | CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | |||
| 152844759 | 180205 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ncc(C3CC3)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4748306 | 180205 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ncc(C3CC3)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585686 | 180359 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 | nan | |||
| CHEMBL4750288 | 180359 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 | nan | |||
| 147641221 | 180402 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1 | nan | |||
| CHEMBL4750914 | 180402 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1 | nan | |||
| 153585718 | 180447 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4751304 | 180447 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585581 | 180468 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2ccc(C#N)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4751501 | 180468 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2ccc(C#N)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585708 | 180563 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 348 | 4 | 1 | 5 | 2.2 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL4752808 | 180563 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 348 | 4 | 1 | 5 | 2.2 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(Cl)cc1 | nan | |||
| 153585648 | 180623 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 366 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4753388 | 180623 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 366 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 162653764 | 180639 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2cc(C3CC3)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4753640 | 180639 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2cc(C3CC3)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585540 | 180714 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 398 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4754565 | 180714 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 398 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 153585467 | 180715 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 | nan | |||
| CHEMBL4754576 | 180715 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 | nan | |||
| 152015494 | 180729 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2c(C3CC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4754735 | 180729 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2c(C3CC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 150352344 | 180877 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4756243 | 180877 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 162655689 | 180889 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 379 | 5 | 1 | 7 | 1.6 | COc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | |||
| CHEMBL4756356 | 180889 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 379 | 5 | 1 | 7 | 1.6 | COc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | |||
| 153585712 | 180897 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 419 | 6 | 2 | 7 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(NC3COC3)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4756431 | 180897 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 419 | 6 | 2 | 7 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(NC3COC3)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585415 | 180994 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O | nan | |||
| CHEMBL4757506 | 180994 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O | nan | |||
| 153585630 | 181101 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 346 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(F)cn3c2=O)cc1F | nan | |||
| CHEMBL4758841 | 181101 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 346 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(F)cn3c2=O)cc1F | nan | |||
| 153585534 | 181190 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 413 | 5 | 1 | 7 | 2.1 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 | nan | |||
| CHEMBL4759991 | 181190 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 413 | 5 | 1 | 7 | 2.1 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 | nan | |||
| 153585651 | 181308 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 382 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nc2cc(Cl)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4761154 | 181308 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 382 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nc2cc(Cl)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585591 | 181382 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)ccc1Cl | nan | |||
| CHEMBL4762126 | 181382 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)ccc1Cl | nan | |||
| 162659465 | 181426 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 379 | 5 | 1 | 7 | 1.6 | COc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | |||
| CHEMBL4762651 | 181426 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 379 | 5 | 1 | 7 | 1.6 | COc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | |||
| 153585610 | 181551 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ccccn2c1=O | nan | |||
| CHEMBL4764290 | 181551 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ccccn2c1=O | nan | |||
| 153585689 | 181612 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc2c1 | nan | |||
| CHEMBL4764967 | 181612 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc2c1 | nan | |||
| 162661302 | 181623 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 383 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4765018 | 181623 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 383 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585427 | 182087 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 324 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(C)cn3c2=O)cc1 | nan | |||
| CHEMBL4780358 | 182087 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 324 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(C)cn3c2=O)cc1 | nan | |||
| 153585638 | 182306 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 379 | 5 | 1 | 7 | 1.6 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | |||
| CHEMBL4782901 | 182306 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 379 | 5 | 1 | 7 | 1.6 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | |||
| 153585409 | 182577 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 394 | 5 | 1 | 6 | 2.6 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 | nan | |||
| CHEMBL4786542 | 182577 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 394 | 5 | 1 | 6 | 2.6 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 | nan | |||
| 147410414 | 182787 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n12 | nan | |||
| CHEMBL4789252 | 182787 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n12 | nan | |||
| 153585385 | 182923 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 360 | 5 | 1 | 6 | 2.0 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n12 | nan | |||
| CHEMBL4790949 | 182923 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 360 | 5 | 1 | 6 | 2.0 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n12 | nan | |||
| 162671538 | 182935 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 417 | 4 | 1 | 6 | 2.6 | C[C@H](NC(=O)Cn1nc2c(C(F)(F)F)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4791193 | 182935 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 417 | 4 | 1 | 6 | 2.6 | C[C@H](NC(=O)Cn1nc2c(C(F)(F)F)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 162671011 | 183050 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n2n1 | nan | |||
| CHEMBL4792732 | 183050 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n2n1 | nan | |||
| 148156995 | 183061 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 460 | 8 | 2 | 8 | 2.3 | C[C@H](NC(=O)Cn1nc2c(NCC(F)F)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4792896 | 183061 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 460 | 8 | 2 | 8 | 2.3 | C[C@H](NC(=O)Cn1nc2c(NCC(F)F)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 151533016 | 183076 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 339 | 5 | 2 | 6 | 1.7 | CNc1cccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc12 | nan | |||
| CHEMBL4793093 | 183076 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 339 | 5 | 2 | 6 | 1.7 | CNc1cccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc12 | nan | |||
| 153585429 | 183518 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)n12 | nan | |||
| CHEMBL4798385 | 183518 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)n12 | nan | |||
| 153585699 | 183607 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 362 | 4 | 1 | 5 | 2.5 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | |||
| CHEMBL4799647 | 183607 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 362 | 4 | 1 | 5 | 2.5 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | |||
| 153585528 | 183670 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1Cl | nan | |||
| CHEMBL4800338 | 183670 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1Cl | nan | |||
| 162644596 | 179525 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | |||
| CHEMBL4740228 | 179525 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | |||
| 153585418 | 179553 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 434 | 5 | 1 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4740519 | 179553 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 434 | 5 | 1 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585684 | 179639 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 377 | 4 | 1 | 6 | 2.2 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | |||
| CHEMBL4741467 | 179639 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 377 | 4 | 1 | 6 | 2.2 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | |||
| 152956498 | 179816 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 324 | 4 | 1 | 5 | 2.2 | Cc1ccc([C@H](C)NC(=O)C(C)n2nc3ccccn3c2=O)cc1 | nan | |||
| CHEMBL4743938 | 179816 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 324 | 4 | 1 | 5 | 2.2 | Cc1ccc([C@H](C)NC(=O)C(C)n2nc3ccccn3c2=O)cc1 | nan | |||
| 153585688 | 179864 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4744340 | 179864 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 162648790 | 179893 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | |||
| CHEMBL4744737 | 179893 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | |||
| 153585420 | 179916 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 364 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | |||
| CHEMBL4744927 | 179916 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 364 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | |||
| 162647825 | 179941 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 | nan | |||
| CHEMBL4745096 | 179941 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 | nan | |||
| 152005060 | 179968 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 447 | 5 | 1 | 8 | 1.3 | C[C@H](NC(=O)Cn1nc2c(N3CCN(C)CC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4745432 | 179968 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 447 | 5 | 1 | 8 | 1.3 | C[C@H](NC(=O)Cn1nc2c(N3CCN(C)CC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 150995037 | 180025 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cnccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4746108 | 180025 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cnccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585512 | 180134 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 367 | 4 | 1 | 6 | 1.7 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4747431 | 180134 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 367 | 4 | 1 | 6 | 1.7 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 162650006 | 180231 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2cccnn2c1=O | nan | |||
| CHEMBL4748681 | 180231 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2cccnn2c1=O | nan | |||
| 151976938 | 180346 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 | nan | |||
| CHEMBL4750143 | 180346 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 | nan | |||
| 153585686 | 180359 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 | nan | |||
| CHEMBL4750288 | 180359 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 | nan | |||
| 147634500 | 180384 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F | nan | |||
| CHEMBL4750692 | 180384 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F | nan | |||
| 147641221 | 180402 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1 | nan | |||
| CHEMBL4750914 | 180402 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1 | nan | |||
| 153585718 | 180447 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4751304 | 180447 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585721 | 180457 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 383 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1nc2ncc(Cl)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4751414 | 180457 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 383 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1nc2ncc(Cl)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585581 | 180468 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2ccc(C#N)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4751501 | 180468 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2ccc(C#N)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585514 | 180479 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1 | nan | |||
| CHEMBL4751629 | 180479 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1 | nan | |||
| 153585541 | 180487 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 341 | 5 | 1 | 7 | 1.1 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc2n1 | nan | |||
| CHEMBL4751720 | 180487 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 341 | 5 | 1 | 7 | 1.1 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc2n1 | nan | |||
| 162653366 | 180566 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 410 | 6 | 2 | 8 | 1.7 | CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc12 | nan | |||
| CHEMBL4752829 | 180566 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 410 | 6 | 2 | 8 | 1.7 | CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc12 | nan | |||
| 153585655 | 180582 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 493 | 7 | 1 | 8 | 2.9 | COC1CCN(c2ccn3c(=O)n(CC(=O)N[C@@H](C)c4ccc(OC(F)(F)F)cc4)nc3c2)CC1 | nan | |||
| CHEMBL4752993 | 180582 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 493 | 7 | 1 | 8 | 2.9 | COC1CCN(c2ccn3c(=O)n(CC(=O)N[C@@H](C)c4ccc(OC(F)(F)F)cc4)nc3c2)CC1 | nan | |||
| 153585421 | 180627 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 447 | 5 | 1 | 7 | 2.4 | CC1COCCN1c1cccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n12 | nan | |||
| CHEMBL4753419 | 180627 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 447 | 5 | 1 | 7 | 2.4 | CC1COCCN1c1cccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n12 | nan | |||
| 147378727 | 180633 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 380 | 6 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)c(F)c1 | nan | |||
| CHEMBL4753547 | 180633 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 380 | 6 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)c(F)c1 | nan | |||
| 162653797 | 180636 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1F | nan | |||
| CHEMBL4753587 | 180636 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1F | nan | |||
| 148512747 | 180663 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1nccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc12 | nan | |||
| CHEMBL4753915 | 180663 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1nccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc12 | nan | |||
| 149101043 | 180709 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4754476 | 180709 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 153585478 | 180711 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4754503 | 180711 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 153585540 | 180714 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 398 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4754565 | 180714 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 398 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 153585445 | 180863 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 382 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| CHEMBL4756137 | 180863 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 382 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| 94095050 | 180917 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 380 | 5 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4756787 | 180917 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 380 | 5 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 162657043 | 180928 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 379 | 5 | 1 | 7 | 1.6 | COc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2n1 | nan | |||
| CHEMBL4756879 | 180928 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 379 | 5 | 1 | 7 | 1.6 | COc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2n1 | nan | |||
| 162656575 | 180989 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 355 | 5 | 1 | 6 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)c(F)c1 | nan | |||
| CHEMBL4757480 | 180989 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 355 | 5 | 1 | 6 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)c(F)c1 | nan | |||
| 162656504 | 181002 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 420 | 6 | 2 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4757619 | 181002 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 420 | 6 | 2 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 152460205 | 181040 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 451 | 6 | 2 | 8 | 1.5 | C[C@H](NC(=O)Cn1nc2cccc(N3CC(O)C3)n2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4758096 | 181040 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 451 | 6 | 2 | 8 | 1.5 | C[C@H](NC(=O)Cn1nc2cccc(N3CC(O)C3)n2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 153585448 | 181056 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 411 | 6 | 1 | 8 | 1.7 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2n1 | nan | |||
| CHEMBL4758322 | 181056 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 411 | 6 | 1 | 8 | 1.7 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2n1 | nan | |||
| 149421402 | 181062 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 452 | 7 | 1 | 8 | 2.1 | C[C@H](NC(=O)Cn1nc2cc(OC3COC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4758375 | 181062 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 452 | 7 | 1 | 8 | 2.1 | C[C@H](NC(=O)Cn1nc2cc(OC3COC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 162657688 | 181161 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)ccc1Cl | nan | |||
| CHEMBL4759611 | 181161 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)ccc1Cl | nan | |||
| 162657416 | 181226 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | |||
| CHEMBL4760528 | 181226 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | |||
| 150924716 | 181272 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1cccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc12 | nan | |||
| CHEMBL4760914 | 181272 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1cccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc12 | nan | |||
| 153585574 | 181327 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)[C@@H](C)n1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4761321 | 181327 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)[C@@H](C)n1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 162660420 | 181381 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 5 | 1 | 6 | 2.0 | CC[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4762121 | 181381 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 5 | 1 | 6 | 2.0 | CC[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585591 | 181382 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)ccc1Cl | nan | |||
| CHEMBL4762126 | 181382 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)ccc1Cl | nan | |||
| 147987797 | 181390 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 364 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| CHEMBL4762206 | 181390 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 364 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| 147323186 | 181490 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 325 | 4 | 1 | 6 | 1.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cnc(C)cn3c2=O)cc1 | nan | |||
| CHEMBL4763362 | 181490 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 325 | 4 | 1 | 6 | 1.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cnc(C)cn3c2=O)cc1 | nan | |||
| 153585610 | 181551 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ccccn2c1=O | nan | |||
| CHEMBL4764290 | 181551 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ccccn2c1=O | nan | |||
| 162661581 | 181570 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 362 | 4 | 1 | 5 | 2.7 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ccccn2c1=O | nan | |||
| CHEMBL4764506 | 181570 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 362 | 4 | 1 | 5 | 2.7 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ccccn2c1=O | nan | |||
| 152494840 | 181603 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC(O)CC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4764839 | 181603 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC(O)CC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 162661302 | 181623 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 383 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4765018 | 181623 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 383 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585547 | 181847 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 420 | 6 | 2 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4777214 | 181847 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 420 | 6 | 2 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 162644369 | 181936 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 343 | 4 | 1 | 6 | 1.5 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(C)ccnn3c2=O)cc1F | nan | |||
| CHEMBL4778327 | 181936 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 343 | 4 | 1 | 6 | 1.5 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(C)ccnn3c2=O)cc1F | nan | |||
| 162665057 | 182172 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | |||
| CHEMBL4781404 | 182172 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | |||
| 150561998 | 182237 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 475 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1nc2c(I)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4782195 | 182237 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 475 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1nc2c(I)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 149618414 | 182367 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 325 | 4 | 2 | 6 | 1.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(N)cccn3c2=O)cc1 | nan | |||
| CHEMBL4783739 | 182367 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 325 | 4 | 2 | 6 | 1.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(N)cccn3c2=O)cc1 | nan | |||
| 153585463 | 182513 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 433 | 5 | 1 | 7 | 2.0 | C[C@H](NC(=O)Cn1nc2cccc(N3CCOCC3)n2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4785639 | 182513 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 433 | 5 | 1 | 7 | 2.0 | C[C@H](NC(=O)Cn1nc2cccc(N3CCOCC3)n2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585417 | 182533 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1Cl | nan | |||
| CHEMBL4785963 | 182533 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1Cl | nan | |||
| 153585609 | 182578 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 465 | 6 | 1 | 8 | 2.1 | C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4786573 | 182578 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 465 | 6 | 1 | 8 | 2.1 | C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 151394869 | 182642 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4787308 | 182642 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585701 | 182659 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 463 | 6 | 1 | 7 | 3.3 | C[C@H](NC(=O)Cn1nc2cccc(N3CCCCC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4787547 | 182659 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 463 | 6 | 1 | 7 | 3.3 | C[C@H](NC(=O)Cn1nc2cccc(N3CCCCC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 151043804 | 182781 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4789123 | 182781 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 162670176 | 182857 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 377 | 5 | 1 | 6 | 2.2 | CC(C)[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4790080 | 182857 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 377 | 5 | 1 | 6 | 2.2 | CC(C)[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585385 | 182923 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 360 | 5 | 1 | 6 | 2.0 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n12 | nan | |||
| CHEMBL4790949 | 182923 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 360 | 5 | 1 | 6 | 2.0 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n12 | nan | |||
| 153585679 | 183029 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1F | nan | |||
| CHEMBL4792515 | 183029 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1F | nan | |||
| 162671011 | 183050 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n2n1 | nan | |||
| CHEMBL4792732 | 183050 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n2n1 | nan | |||
| 148156995 | 183061 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 460 | 8 | 2 | 8 | 2.3 | C[C@H](NC(=O)Cn1nc2c(NCC(F)F)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4792896 | 183061 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 460 | 8 | 2 | 8 | 2.3 | C[C@H](NC(=O)Cn1nc2c(NCC(F)F)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 153585524 | 183236 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(F)cccn3c2=O)cc1 | nan | |||
| CHEMBL4795078 | 183236 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(F)cccn3c2=O)cc1 | nan | |||
| 153585504 | 183317 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | |||
| CHEMBL4795956 | 183317 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | |||
| 153585386 | 183339 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2ccc(Cl)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4796254 | 183339 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2ccc(Cl)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 153585438 | 183466 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2c1 | nan | |||
| CHEMBL4797724 | 183466 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2c1 | nan | |||
| 153585532 | 183498 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(F)n3c2=O)cc1 | nan | |||
| CHEMBL4798029 | 183498 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(F)n3c2=O)cc1 | nan | |||
| 153585429 | 183518 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)n12 | nan | |||
| CHEMBL4798385 | 183518 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)n12 | nan | |||
| 153585528 | 183670 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1Cl | nan | |||
| CHEMBL4800338 | 183670 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1Cl | nan | |||
| 153585707 | 183684 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 361 | 5 | 1 | 7 | 1.4 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc2n1 | nan | |||
| CHEMBL4800487 | 183684 | None | 0 | Rat | Binding | pEC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 361 | 5 | 1 | 7 | 1.4 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc2n1 | nan | |||
| 162644596 | 179525 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | |||
| CHEMBL4740228 | 179525 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | |||
| 162648790 | 179893 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | |||
| CHEMBL4744737 | 179893 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | |||
| 162647825 | 179941 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 | nan | |||
| CHEMBL4745096 | 179941 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 | nan | |||
| 162649809 | 180151 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 458 | 5 | 1 | 7 | 2.1 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CN(C)C4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4747632 | 180151 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 458 | 5 | 1 | 7 | 2.1 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CN(C)C4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 151976938 | 180346 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 | nan | |||
| CHEMBL4750143 | 180346 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 | nan | |||
| 147634500 | 180384 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F | nan | |||
| CHEMBL4750692 | 180384 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F | nan | |||
| 149094095 | 180388 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 421 | 6 | 1 | 7 | 2.5 | C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4750718 | 180388 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 421 | 6 | 1 | 7 | 2.5 | C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 162653366 | 180566 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 410 | 6 | 2 | 8 | 1.7 | CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc12 | nan | |||
| CHEMBL4752829 | 180566 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 410 | 6 | 2 | 8 | 1.7 | CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc12 | nan | |||
| 162653797 | 180636 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1F | nan | |||
| CHEMBL4753587 | 180636 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1F | nan | |||
| 152007746 | 180672 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 368 | 5 | 1 | 6 | 2.3 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3c(C)cc(C)cc3C)nc2c1 | nan | |||
| CHEMBL4754043 | 180672 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 368 | 5 | 1 | 6 | 2.3 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3c(C)cc(C)cc3C)nc2c1 | nan | |||
| 153585713 | 181077 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(F)cn3c2=O)cc1 | nan | |||
| CHEMBL4758561 | 181077 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(F)cn3c2=O)cc1 | nan | |||
| 153585574 | 181327 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)[C@@H](C)n1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4761321 | 181327 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)[C@@H](C)n1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 147987797 | 181390 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 364 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| CHEMBL4762206 | 181390 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 364 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| 162661581 | 181570 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 362 | 4 | 1 | 5 | 2.7 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ccccn2c1=O | nan | |||
| CHEMBL4764506 | 181570 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 362 | 4 | 1 | 5 | 2.7 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ccccn2c1=O | nan | |||
| 153585547 | 181847 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 420 | 6 | 2 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4777214 | 181847 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 420 | 6 | 2 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 162644369 | 181936 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 343 | 4 | 1 | 6 | 1.5 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(C)ccnn3c2=O)cc1F | nan | |||
| CHEMBL4778327 | 181936 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 343 | 4 | 1 | 6 | 1.5 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(C)ccnn3c2=O)cc1F | nan | |||
| 162665057 | 182172 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | |||
| CHEMBL4781404 | 182172 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | |||
| 151043804 | 182781 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4789123 | 182781 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585679 | 183029 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1F | nan | |||
| CHEMBL4792515 | 183029 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1F | nan | |||
| 162670606 | 183044 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2n1 | nan | |||
| CHEMBL4792682 | 183044 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2n1 | nan | |||
| 153585386 | 183339 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2ccc(Cl)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4796254 | 183339 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2ccc(Cl)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 153585532 | 183498 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(F)n3c2=O)cc1 | nan | |||
| CHEMBL4798029 | 183498 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(F)n3c2=O)cc1 | nan | |||
| 147477854 | 183604 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 433 | 5 | 1 | 7 | 2.0 | C[C@H](NC(=O)Cn1nc2c(N3CCOCC3)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4799618 | 183604 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 433 | 5 | 1 | 7 | 2.0 | C[C@H](NC(=O)Cn1nc2c(N3CCOCC3)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 162644596 | 179525 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | |||
| CHEMBL4740228 | 179525 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | |||
| 162648528 | 179920 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 337 | 5 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)cc1 | nan | |||
| CHEMBL4744984 | 179920 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 337 | 5 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)cc1 | nan | |||
| 146976458 | 180136 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 507 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2c(I)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4747440 | 180136 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 507 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2c(I)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 162649809 | 180151 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 458 | 5 | 1 | 7 | 2.1 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CN(C)C4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4747632 | 180151 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 458 | 5 | 1 | 7 | 2.1 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CN(C)C4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 152844759 | 180205 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ncc(C3CC3)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4748306 | 180205 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ncc(C3CC3)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585550 | 180499 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 355 | 5 | 1 | 6 | 1.8 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(C2CC2)c(F)c1 | nan | |||
| CHEMBL4751886 | 180499 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 355 | 5 | 1 | 6 | 1.8 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(C2CC2)c(F)c1 | nan | |||
| 152007746 | 180672 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 368 | 5 | 1 | 6 | 2.3 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3c(C)cc(C)cc3C)nc2c1 | nan | |||
| CHEMBL4754043 | 180672 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 368 | 5 | 1 | 6 | 2.3 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3c(C)cc(C)cc3C)nc2c1 | nan | |||
| 153585588 | 180892 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 444 | 5 | 2 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CNC4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4756392 | 180892 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 444 | 5 | 2 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CNC4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585575 | 180935 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 433 | 5 | 2 | 8 | 1.0 | C[C@H](NC(=O)Cn1nc2c(N3CCNCC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| CHEMBL4756937 | 180935 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 433 | 5 | 2 | 8 | 1.0 | C[C@H](NC(=O)Cn1nc2c(N3CCNCC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | |||
| 153585415 | 180994 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O | nan | |||
| CHEMBL4757506 | 180994 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O | nan | |||
| 153585534 | 181190 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 413 | 5 | 1 | 7 | 2.1 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 | nan | |||
| CHEMBL4759991 | 181190 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 413 | 5 | 1 | 7 | 2.1 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 | nan | |||
| 153585663 | 181261 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1Cl | nan | |||
| CHEMBL4760812 | 181261 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1Cl | nan | |||
| 153585643 | 181447 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 381 | 5 | 1 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4762957 | 181447 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 381 | 5 | 1 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 134043805 | 181875 | None | 1 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 362 | 6 | 1 | 6 | 2.0 | CC(NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)cc1 | nan | |||
| CHEMBL4777673 | 181875 | None | 1 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 362 | 6 | 1 | 6 | 2.0 | CC(NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)cc1 | nan | |||
| 153585542 | 182412 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | |||
| CHEMBL4784153 | 182412 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | |||
| 162667558 | 182568 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 331 | 4 | 1 | 6 | 1.4 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL4786371 | 182568 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 331 | 4 | 1 | 6 | 1.4 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)cc1 | nan | |||
| 147410414 | 182787 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n12 | nan | |||
| CHEMBL4789252 | 182787 | None | 0 | Rat | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n12 | nan | |||
| 121349671 | 181859 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 350 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 | nan | |||
| CHEMBL4777495 | 181859 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 350 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 | nan | |||
| 121349806 | 183480 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| CHEMBL4797857 | 183480 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| 121349656 | 183595 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 424 | 5 | 1 | 6 | 2.8 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3F)c(=O)c12 | nan | |||
| CHEMBL4799483 | 183595 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 424 | 5 | 1 | 6 | 2.8 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3F)c(=O)c12 | nan | |||
| 121349756 | 182673 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 | nan | |||
| CHEMBL4787761 | 182673 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 | nan | |||
| 27785340 | 183577 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4799237 | 183577 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | 10.1021/acs.jmedchem.1c00820 | |||
| 27785340 | 183577 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | nan | |||
| CHEMBL4799237 | 183577 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | nan | |||
| 121349782 | 183150 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c2c1 | nan | |||
| CHEMBL4794046 | 183150 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c2c1 | nan | |||
| 164619649 | 185872 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccccc1Cl | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4866435 | 185872 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccccc1Cl | 10.1021/acs.jmedchem.1c00820 | |||
| 26810968 | 186389 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 358 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1cccc2ccccc12 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4874147 | 186389 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 358 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1cccc2ccccc12 | 10.1021/acs.jmedchem.1c00820 | |||
| 11685 | 4139 | None | 28 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349608 | 4139 | None | 28 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4779773 | 4139 | None | 28 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 10.1021/acs.jmedchem.1c00820 | |||
| 11685 | 4139 | None | 28 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | nan | |||
| 121349608 | 4139 | None | 28 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | nan | |||
| CHEMBL4779773 | 4139 | None | 28 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | nan | |||
| 121349786 | 182359 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 404 | 7 | 1 | 7 | 2.3 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4783626 | 182359 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 404 | 7 | 1 | 7 | 2.3 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349639 | 182523 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4785741 | 182523 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F | 10.1021/acs.jmedchem.1c00820 | |||
| 121349786 | 182359 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 404 | 7 | 1 | 7 | 2.3 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 | nan | |||
| CHEMBL4783626 | 182359 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 404 | 7 | 1 | 7 | 2.3 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 | nan | |||
| 121349639 | 182523 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F | nan | |||
| CHEMBL4785741 | 182523 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F | nan | |||
| 2695546 | 186222 | None | 9 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4871792 | 186222 | None | 9 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349600 | 182691 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c2c1 | nan | |||
| CHEMBL4788013 | 182691 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c2c1 | nan | |||
| 121349548 | 183535 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 338 | 5 | 1 | 6 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4798667 | 183535 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 338 | 5 | 1 | 6 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349548 | 183535 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 338 | 5 | 1 | 6 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | |||
| CHEMBL4798667 | 183535 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 338 | 5 | 1 | 6 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | |||
| 121349554 | 183645 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(OC)ccc3c2=O)cc1 | nan | |||
| CHEMBL4800089 | 183645 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(OC)ccc3c2=O)cc1 | nan | |||
| 36428174 | 182048 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 376 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4779855 | 182048 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 376 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 36428174 | 182048 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 376 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| CHEMBL4779855 | 182048 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 376 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| 121349659 | 182371 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 | nan | |||
| CHEMBL4783774 | 182371 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 | nan | |||
| 121349593 | 182979 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4791792 | 182979 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F | 10.1021/acs.jmedchem.1c00820 | |||
| 121349593 | 182979 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F | nan | |||
| CHEMBL4791792 | 182979 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F | nan | |||
| 121349633 | 182823 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4789631 | 182823 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | 10.1021/acs.jmedchem.1c00820 | |||
| 121349633 | 182823 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | nan | |||
| CHEMBL4789631 | 182823 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | nan | |||
| 2714527 | 185511 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 308 | 4 | 1 | 5 | 1.7 | C[C@@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4861019 | 185511 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 308 | 4 | 1 | 5 | 1.7 | C[C@@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 2714528 | 182584 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 308 | 4 | 1 | 5 | 1.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | nan | |||
| CHEMBL4786641 | 182584 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 308 | 4 | 1 | 5 | 1.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | nan | |||
| 27838947 | 185537 | None | 1 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1cccc(Cl)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4861445 | 185537 | None | 1 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1cccc(Cl)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349658 | 182809 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4789475 | 182809 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349658 | 182809 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 | nan | |||
| CHEMBL4789475 | 182809 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 | nan | |||
| 121349597 | 181917 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(Cl)ccc3c2=O)cc1 | nan | |||
| CHEMBL4778124 | 181917 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(Cl)ccc3c2=O)cc1 | nan | |||
| 121349631 | 182588 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4786722 | 182588 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349631 | 182588 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | nan | |||
| CHEMBL4786722 | 182588 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | nan | |||
| 121349615 | 183231 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 366 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 | nan | |||
| CHEMBL4795005 | 183231 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 366 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 | nan | |||
| 121349564 | 181870 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4777630 | 181870 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349564 | 181870 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | nan | |||
| CHEMBL4777630 | 181870 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | nan | |||
| 121349588 | 182342 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 406 | 6 | 1 | 6 | 3.0 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4783365 | 182342 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 406 | 6 | 1 | 6 | 3.0 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 121349572 | 181952 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4778561 | 181952 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349572 | 181952 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | nan | |||
| CHEMBL4778561 | 181952 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | nan | |||
| 121349778 | 182462 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 3.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 | nan | |||
| CHEMBL4784744 | 182462 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 3.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 | nan | |||
| 164617980 | 185135 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | - | 1 | ChEMBL | 377 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)nc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4855076 | 185135 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | - | 1 | ChEMBL | 377 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)nc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349738 | 182203 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 390 | 5 | 1 | 5 | 3.1 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| CHEMBL4781754 | 182203 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 390 | 5 | 1 | 5 | 3.1 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | |||
| 121349559 | 181942 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc2c1 | nan | |||
| CHEMBL4778354 | 181942 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc2c1 | nan | |||
| 164628435 | 186396 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1cccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4874254 | 186396 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1cccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| 8036946 | 183545 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4798779 | 183545 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 8036946 | 183545 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL4798779 | 183545 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | nan | |||
| 121349701 | 182050 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc12 | nan | |||
| CHEMBL4779884 | 182050 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc12 | nan | |||
| 121349710 | 183054 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | nan | |||
| CHEMBL4792828 | 183054 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | nan | |||
| 121349675 | 182071 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 390 | 4 | 1 | 5 | 3.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 | nan | |||
| CHEMBL4780038 | 182071 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 390 | 4 | 1 | 5 | 3.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 | nan | |||
| 121349683 | 182829 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c12 | nan | |||
| CHEMBL4789720 | 182829 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c12 | nan | |||
| 121349753 | 183000 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4792136 | 183000 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349753 | 183000 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 | nan | |||
| CHEMBL4792136 | 183000 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 | nan | |||
| 78596259 | 185481 | None | 1 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | CC(NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4860510 | 185481 | None | 1 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | CC(NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349739 | 182276 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 392 | 6 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)F)cc1 | nan | |||
| CHEMBL4782619 | 182276 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 392 | 6 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)F)cc1 | nan | |||
| 2496250 | 28960 | None | 4 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 338 | 6 | 1 | 6 | 1.2 | COc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL1380104 | 28960 | None | 4 | Human | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 338 | 6 | 1 | 6 | 1.2 | COc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349685 | 182239 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 440 | 6 | 1 | 7 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4782204 | 182239 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 440 | 6 | 1 | 7 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349685 | 182239 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 440 | 6 | 1 | 7 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 | nan | |||
| CHEMBL4782204 | 182239 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 440 | 6 | 1 | 7 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 | nan | |||
| 121349719 | 183365 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 | nan | |||
| CHEMBL4796493 | 183365 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 | nan | |||
| 121349787 | 182778 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 | nan | |||
| CHEMBL4789079 | 182778 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 | nan | |||
| 121349623 | 182206 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc12 | nan | |||
| CHEMBL4781805 | 182206 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc12 | nan | |||
| 121349755 | 181909 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 | nan | |||
| CHEMBL4778062 | 181909 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 | nan | |||
| 121349773 | 182534 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc2c1 | nan | |||
| CHEMBL4785980 | 182534 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc2c1 | nan | |||
| 121349614 | 181771 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(C)c1 | nan | |||
| CHEMBL4776329 | 181771 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(C)c1 | nan | |||
| 121349720 | 182349 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(OC)cccc3c2=O)cc1 | nan | |||
| CHEMBL4783544 | 182349 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(OC)cccc3c2=O)cc1 | nan | |||
| 121349645 | 181824 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| CHEMBL4776988 | 181824 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | |||
| 164611430 | 185330 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 377 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cn1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4857947 | 185330 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 377 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cn1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349746 | 183490 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 390 | 4 | 1 | 5 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4797979 | 183490 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 390 | 4 | 1 | 5 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349746 | 183490 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 390 | 4 | 1 | 5 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | nan | |||
| CHEMBL4797979 | 183490 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 390 | 4 | 1 | 5 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | nan | |||
| 121349745 | 182318 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4783071 | 182318 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349745 | 182318 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 | nan | |||
| CHEMBL4783071 | 182318 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 | nan | |||
| 8036887 | 184846 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 322 | 5 | 1 | 5 | 1.7 | C[C@@H](CNC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4850747 | 184846 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 322 | 5 | 1 | 5 | 1.7 | C[C@@H](CNC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349781 | 181954 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 | nan | |||
| CHEMBL4778563 | 181954 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 | nan | |||
| 121349596 | 183547 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4798863 | 183547 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349596 | 183547 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | |||
| CHEMBL4798863 | 183547 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | |||
| 121349728 | 181922 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4778172 | 181922 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349728 | 181922 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 | nan | |||
| CHEMBL4778172 | 181922 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 | nan | |||
| 121349688 | 183004 | None | 0 | Human | Binding | pKi | = | 5.3 | 5.3 | - | 1 | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 | nan | |||
| CHEMBL4792174 | 183004 | None | 0 | Human | Binding | pKi | = | 5.3 | 5.3 | - | 1 | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 | nan | |||
| 27783537 | 181789 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 386 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4776509 | 181789 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 386 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349587 | 182518 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 | nan | |||
| CHEMBL4785669 | 182518 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 | nan | |||
| 121349769 | 183033 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 | nan | |||
| CHEMBL4792561 | 183033 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 | nan | |||
| 121349689 | 183325 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 372 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | nan | |||
| CHEMBL4796061 | 183325 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 372 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | nan | |||
| 121349780 | 186475 | None | 0 | Human | Binding | pKi | = | 5.3 | 5.3 | - | 1 | ChEMBL | 322 | 5 | 1 | 5 | 1.5 | Cc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4875522 | 186475 | None | 0 | Human | Binding | pKi | = | 5.3 | 5.3 | - | 1 | ChEMBL | 322 | 5 | 1 | 5 | 1.5 | Cc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349628 | 182131 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4780801 | 182131 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349628 | 182131 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 | nan | |||
| CHEMBL4780801 | 182131 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 | nan | |||
| 121349805 | 183226 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(OC)c3c2=O)cc1 | nan | |||
| CHEMBL4794908 | 183226 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(OC)c3c2=O)cc1 | nan | |||
| 27754276 | 186037 | None | 0 | Human | Binding | pKi | = | 5.2 | 5.2 | - | 1 | ChEMBL | 336 | 5 | 1 | 5 | 2.4 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4869182 | 186037 | None | 0 | Human | Binding | pKi | = | 5.2 | 5.2 | - | 1 | ChEMBL | 336 | 5 | 1 | 5 | 2.4 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349734 | 182202 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4781729 | 182202 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349734 | 182202 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 | nan | |||
| CHEMBL4781729 | 182202 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 | nan | |||
| 121349574 | 182925 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4790968 | 182925 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349574 | 182925 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 | nan | |||
| CHEMBL4790968 | 182925 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 | nan | |||
| 121349569 | 182021 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 | nan | |||
| CHEMBL4779481 | 182021 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 | nan | |||
| 164609046 | 184591 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.5 | Cc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4847108 | 184591 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.5 | Cc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349561 | 182836 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 | nan | |||
| CHEMBL4789791 | 182836 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 | nan | |||
| 121349719 | 183365 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4796493 | 183365 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349711 | 182973 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 358 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(F)c1 | nan | |||
| CHEMBL4791752 | 182973 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 358 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(F)c1 | nan | |||
| 121349694 | 182321 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4783106 | 182321 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349694 | 182321 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 | nan | |||
| CHEMBL4783106 | 182321 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 | nan | |||
| 121349679 | 186374 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | - | 1 | ChEMBL | 352 | 6 | 1 | 6 | 1.5 | COc1ccc(C[C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4873905 | 186374 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | - | 1 | ChEMBL | 352 | 6 | 1 | 6 | 1.5 | COc1ccc(C[C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349566 | 182758 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | - | 1 | ChEMBL | 372 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 | nan | |||
| CHEMBL4788831 | 182758 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | - | 1 | ChEMBL | 372 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 | nan | |||
| 164621186 | 186200 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 323 | 4 | 0 | 6 | 2.4 | Cc1ccc([C@H](C)OC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4871591 | 186200 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 323 | 4 | 0 | 6 | 2.4 | Cc1ccc([C@H](C)OC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349767 | 183436 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4797410 | 183436 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349767 | 183436 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 | nan | |||
| CHEMBL4797410 | 183436 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 | nan | |||
| 164620725 | 186191 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.2 | COc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4871506 | 186191 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.2 | COc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 121349809 | 183267 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | nan | |||
| CHEMBL4795372 | 183267 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | nan | |||
| 121349740 | 182197 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | nan | |||
| CHEMBL4781651 | 182197 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | nan | |||
| 121349795 | 183555 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 | nan | |||
| CHEMBL4798933 | 183555 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 | nan | |||
| 121349558 | 182078 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 428 | 5 | 1 | 6 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1F | nan | |||
| CHEMBL4780121 | 182078 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 428 | 5 | 1 | 6 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1F | nan | |||
| 41757362 | 182319 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 352 | 6 | 1 | 6 | 2.1 | CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| CHEMBL4783081 | 182319 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 352 | 6 | 1 | 6 | 2.1 | CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | |||
| 41757362 | 182319 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 352 | 6 | 1 | 6 | 2.1 | CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | |||
| CHEMBL4783081 | 182319 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 352 | 6 | 1 | 6 | 2.1 | CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | |||
| 2144 | 2356 | None | 0 | Human | Binding | pKi | = | 3.1 | 3.1 | - | 1 | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | |||
| 3313 | 2356 | None | 0 | Human | Binding | pKi | = | 3.1 | 3.1 | - | 1 | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | |||
| 6140 | 2356 | None | 0 | Human | Binding | pKi | = | 3.1 | 3.1 | - | 1 | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | |||
| 6925665 | 2356 | None | 0 | Human | Binding | pKi | = | 3.1 | 3.1 | - | 1 | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | |||
| CHEMBL301523 | 2356 | None | 0 | Human | Binding | pKi | = | 3.1 | 3.1 | - | 1 | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | |||
| DB00120 | 2356 | None | 0 | Human | Binding | pKi | = | 3.1 | 3.1 | - | 1 | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | |||
| 2780 | 2373 | None | 60 | Human | Binding | pKi | = | 3.1 | 3.1 | -630 | 2 | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | |||
| 6305 | 2373 | None | 60 | Human | Binding | pKi | = | 3.1 | 3.1 | -630 | 2 | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | |||
| 6923516 | 2373 | None | 60 | Human | Binding | pKi | = | 3.1 | 3.1 | -630 | 2 | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | |||
| 717 | 2373 | None | 60 | Human | Binding | pKi | = | 3.1 | 3.1 | -630 | 2 | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | |||
| CHEMBL54976 | 2373 | None | 60 | Human | Binding | pKi | = | 3.1 | 3.1 | -630 | 2 | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | |||
| DB00150 | 2373 | None | 60 | Human | Binding | pKi | = | 3.1 | 3.1 | -630 | 2 | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | |||
| 11685 | 4139 | None | 28 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | Guide to Pharmacology | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 34260228 | |||
| 121349608 | 4139 | None | 28 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | Guide to Pharmacology | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 34260228 | |||
| CHEMBL4779773 | 4139 | None | 28 | Human | Binding | pKi | = | 6.9 | 6.9 | - | 1 | Guide to Pharmacology | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 34260228 | |||
| 2548547 | 2149 | None | 39 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | Guide to Pharmacology | 316 | 5 | 2 | 2 | 2.9 | O=C(N[C@H](c1ccccc1)C)CNC(=O)c1cccc(c1)Cl | 26349500 | |||
| 8766 | 2149 | None | 39 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | Guide to Pharmacology | 316 | 5 | 2 | 2 | 2.9 | O=C(N[C@H](c1ccccc1)C)CNC(=O)c1cccc(c1)Cl | 26349500 | |||
| CHEMBL3633720 | 2149 | None | 39 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | Guide to Pharmacology | 316 | 5 | 2 | 2 | 2.9 | O=C(N[C@H](c1ccccc1)C)CNC(=O)c1cccc(c1)Cl | 26349500 | |||