Ligand source activities (1 row/activity)





Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name
GPCRdb
ID
Reference
ligand
Vendors

Species

Assay
Type

Activity
Type
Activity
Relation
Activity
Value
p-value
(-log)
Fold
selectivity
Tested
GPCRs
Assay
Description
Source

Mol
weight
Rot
Bonds
H don

H acc

LogP

Smiles

DOI

136036237 188746 None 0 Human Functional pEC50 = 5.9 5.9 -3 2
Agonist activity at human MrgX2 receptorAgonist activity at human MrgX2 receptor
ChEMBL 632 7 3 6 5.9 CCC(C)[C@H]1C(=O)Nc2ccc(N3CCC(NC(C)=O)C3)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 10.1016/j.bmcl.2009.01.085
CHEMBL503202 188746 None 0 Human Functional pEC50 = 5.9 5.9 -3 2
Agonist activity at human MrgX2 receptorAgonist activity at human MrgX2 receptor
ChEMBL 632 7 3 6 5.9 CCC(C)[C@H]1C(=O)Nc2ccc(N3CCC(NC(C)=O)C3)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 10.1016/j.bmcl.2009.01.085
136036259 188770 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human MrgX2 receptorAgonist activity at human MrgX2 receptor
ChEMBL 550 6 2 6 5.6 CC(C)[C@H]1C(=O)Nc2ccc(NCc3ccccc3)cc2-c2nc3cc(C(=O)N(C)C4CCN(C)CC4)ccc3n21 10.1016/j.bmcl.2009.01.085
CHEMBL503688 188770 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human MrgX2 receptorAgonist activity at human MrgX2 receptor
ChEMBL 550 6 2 6 5.6 CC(C)[C@H]1C(=O)Nc2ccc(NCc3ccccc3)cc2-c2nc3cc(C(=O)N(C)C4CCN(C)CC4)ccc3n21 10.1016/j.bmcl.2009.01.085
136036261 188860 None 0 Human Functional pEC50 = 5.7 5.7 -10 2
Agonist activity at human MrgX2 receptorAgonist activity at human MrgX2 receptor
ChEMBL 632 9 3 6 7.1 CCC(C)[C@H]1C(=O)Nc2ccc(NCCN3CCCCC3)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 10.1016/j.bmcl.2009.01.085
CHEMBL505263 188860 None 0 Human Functional pEC50 = 5.7 5.7 -10 2
Agonist activity at human MrgX2 receptorAgonist activity at human MrgX2 receptor
ChEMBL 632 9 3 6 7.1 CCC(C)[C@H]1C(=O)Nc2ccc(NCCN3CCCCC3)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 10.1016/j.bmcl.2009.01.085
135407952 1060 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human MrgX2 receptorAgonist activity at human MrgX2 receptor
ChEMBL 542 4 2 6 5.8 CN1CCCN(CC1)C(=O)c1ccc2c(c1)nc1n2[C@@H](C(C)C)C(=O)Nc2c1cc(cc2)NC1CCCCCC1 10.1016/j.bmcl.2009.01.085
5530 1060 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human MrgX2 receptorAgonist activity at human MrgX2 receptor
ChEMBL 542 4 2 6 5.8 CN1CCCN(CC1)C(=O)c1ccc2c(c1)nc1n2[C@@H](C(C)C)C(=O)Nc2c1cc(cc2)NC1CCCCCC1 10.1016/j.bmcl.2009.01.085
CHEMBL463274 1060 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human MrgX2 receptorAgonist activity at human MrgX2 receptor
ChEMBL 542 4 2 6 5.8 CN1CCCN(CC1)C(=O)c1ccc2c(c1)nc1n2[C@@H](C(C)C)C(=O)Nc2c1cc(cc2)NC1CCCCCC1 10.1016/j.bmcl.2009.01.085
135869412 188550 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at human MrgX2 receptorAgonist activity at human MrgX2 receptor
ChEMBL 619 6 1 7 5.3 CC(C)[C@H]1C(=O)Nc2ccc(N3CCN(Cc4ccccc4)CC3)cc2-c2nc3cc(C(=O)N(C)C4CCN(C)CC4)ccc3n21 10.1016/j.bmcl.2009.01.085
CHEMBL502480 188550 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at human MrgX2 receptorAgonist activity at human MrgX2 receptor
ChEMBL 619 6 1 7 5.3 CC(C)[C@H]1C(=O)Nc2ccc(N3CCN(Cc4ccccc4)CC3)cc2-c2nc3cc(C(=O)N(C)C4CCN(C)CC4)ccc3n21 10.1016/j.bmcl.2009.01.085
CHEMBL2448526 212959 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human MrgX2 receptorAgonist activity at human MrgX2 receptor
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2)CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2ccccc2)NC1=O 10.1016/j.bmcl.2009.01.085
135407930 188527 None 0 Human Functional pEC50 = 6.2 6.2 -10 2
Agonist activity at human MrgX2 receptorAgonist activity at human MrgX2 receptor
ChEMBL 606 10 3 6 6.6 CCC(C)[C@H]1C(=O)Nc2ccc(NCCCN(C)C)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 10.1016/j.bmcl.2009.01.085
CHEMBL502132 188527 None 0 Human Functional pEC50 = 6.2 6.2 -10 2
Agonist activity at human MrgX2 receptorAgonist activity at human MrgX2 receptor
ChEMBL 606 10 3 6 6.6 CCC(C)[C@H]1C(=O)Nc2ccc(NCCCN(C)C)cc2-c2nc3cc(C(=O)NCc4cccc(C(F)(F)F)c4)ccc3n21 10.1016/j.bmcl.2009.01.085
164734529 190948 None 3 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at human MRGPRX2 expressed in HEK293 cells co-expressing mouse Galpha15 assessed as inhibition of Cortistatin-14 induced Ca2+ mobilization preincubated for 30 mins followed by Cortistatin-14 addition by FLIPRtetra-calcium mobilization assayAntagonist activity at human MRGPRX2 expressed in HEK293 cells co-expressing mouse Galpha15 assessed as inhibition of Cortistatin-14 induced Ca2+ mobilization preincubated for 30 mins followed by Cortistatin-14 addition by FLIPRtetra-calcium mobilization assay
ChEMBL 491 6 1 6 3.6 C[C@@H](C(=O)Nc1cnc(Oc2ccc(F)cc2F)cn1)N1CCC(F)(F)[C@@H](c2cc[n+]([O-])cc2)C1 10.1021/acsmedchemlett.2c00262
CHEMBL5184300 190948 None 3 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at human MRGPRX2 expressed in HEK293 cells co-expressing mouse Galpha15 assessed as inhibition of Cortistatin-14 induced Ca2+ mobilization preincubated for 30 mins followed by Cortistatin-14 addition by FLIPRtetra-calcium mobilization assayAntagonist activity at human MRGPRX2 expressed in HEK293 cells co-expressing mouse Galpha15 assessed as inhibition of Cortistatin-14 induced Ca2+ mobilization preincubated for 30 mins followed by Cortistatin-14 addition by FLIPRtetra-calcium mobilization assay
ChEMBL 491 6 1 6 3.6 C[C@@H](C(=O)Nc1cnc(Oc2ccc(F)cc2F)cn1)N1CCC(F)(F)[C@@H](c2cc[n+]([O-])cc2)C1 10.1021/acsmedchemlett.2c00262
9567 3750 None 6 Human Functional pEC50 = 5.7 5.7 -1819 3
Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).
Guide to Pharmacology 344 1 1 3 3.9 CN1CC[C@]2([C@H](C1)Cc1c(C2)nc2c(c1)cccc2)c1cccc(c1)O 11765135
9567 3750 None 6 Human Functional pEC50 = 5.7 5.7 -1819 3
Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).
Guide to Pharmacology 344 1 1 3 3.9 CN1CC[C@]2([C@H](C1)Cc1c(C2)nc2c(c1)cccc2)c1cccc(c1)O 23396314
9567 3750 None 6 Human Functional pEC50 = 5.7 5.7 -1819 3
Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).
Guide to Pharmacology 344 1 1 3 3.9 CN1CC[C@]2([C@H](C1)Cc1c(C2)nc2c(c1)cccc2)c1cccc(c1)O 28288109
9950038 3750 None 6 Human Functional pEC50 = 5.7 5.7 -1819 3
Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).
Guide to Pharmacology 344 1 1 3 3.9 CN1CC[C@]2([C@H](C1)Cc1c(C2)nc2c(c1)cccc2)c1cccc(c1)O 11765135
9950038 3750 None 6 Human Functional pEC50 = 5.7 5.7 -1819 3
Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).
Guide to Pharmacology 344 1 1 3 3.9 CN1CC[C@]2([C@H](C1)Cc1c(C2)nc2c(c1)cccc2)c1cccc(c1)O 23396314
9950038 3750 None 6 Human Functional pEC50 = 5.7 5.7 -1819 3
Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).
Guide to Pharmacology 344 1 1 3 3.9 CN1CC[C@]2([C@H](C1)Cc1c(C2)nc2c(c1)cccc2)c1cccc(c1)O 28288109
CHEMBL327745 3750 None 6 Human Functional pEC50 = 5.7 5.7 -1819 3
Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).
Guide to Pharmacology 344 1 1 3 3.9 CN1CC[C@]2([C@H](C1)Cc1c(C2)nc2c(c1)cccc2)c1cccc(c1)O 11765135
CHEMBL327745 3750 None 6 Human Functional pEC50 = 5.7 5.7 -1819 3
Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).
Guide to Pharmacology 344 1 1 3 3.9 CN1CC[C@]2([C@H](C1)Cc1c(C2)nc2c(c1)cccc2)c1cccc(c1)O 23396314
CHEMBL327745 3750 None 6 Human Functional pEC50 = 5.7 5.7 -1819 3
Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).Assayed using racemic TAN-67, the more active stereoisomer is the (4aS,12aR).
Guide to Pharmacology 344 1 1 3 3.9 CN1CC[C@]2([C@H](C1)Cc1c(C2)nc2c(c1)cccc2)c1cccc(c1)O 28288109
10567 1837 None 0 Human Functional pEC50 = 5.7 5.7 -1 3
Determined in a FLIPR calcium imaging assay using HEK cells heterologously expressing hMRGPRX2Determined in a FLIPR calcium imaging assay using HEK cells heterologously expressing hMRGPRX2
Guide to Pharmacology None None None None 35704588
145996510 1837 None 0 Human Functional pEC50 = 5.7 5.7 -1 3
Determined in a FLIPR calcium imaging assay using HEK cells heterologously expressing hMRGPRX2Determined in a FLIPR calcium imaging assay using HEK cells heterologously expressing hMRGPRX2
Guide to Pharmacology None None None None 35704588
2098 3694 None 31 Human Functional pEC50 = 6.0 6.0 -2089 11
In a calcium mobilisation asay.In a calcium mobilisation asay.
Guide to Pharmacology None None None None 25517090
2098 3694 None 31 Human Functional pEC50 = 6.0 6.0 -2089 11
In a calcium mobilisation asay.In a calcium mobilisation asay.
Guide to Pharmacology None None None None 28288109
36511 3694 None 31 Human Functional pEC50 = 6.0 6.0 -2089 11
In a calcium mobilisation asay.In a calcium mobilisation asay.
Guide to Pharmacology None None None None 25517090
36511 3694 None 31 Human Functional pEC50 = 6.0 6.0 -2089 11
In a calcium mobilisation asay.In a calcium mobilisation asay.
Guide to Pharmacology None None None None 28288109
3805 3694 None 31 Human Functional pEC50 = 6.0 6.0 -2089 11
In a calcium mobilisation asay.In a calcium mobilisation asay.
Guide to Pharmacology None None None None 25517090
3805 3694 None 31 Human Functional pEC50 = 6.0 6.0 -2089 11
In a calcium mobilisation asay.In a calcium mobilisation asay.
Guide to Pharmacology None None None None 28288109
3835 3694 None 31 Human Functional pEC50 = 6.0 6.0 -2089 11
In a calcium mobilisation asay.In a calcium mobilisation asay.
Guide to Pharmacology None None None None 25517090
3835 3694 None 31 Human Functional pEC50 = 6.0 6.0 -2089 11
In a calcium mobilisation asay.In a calcium mobilisation asay.
Guide to Pharmacology None None None None 28288109
CHEMBL235363 3694 None 31 Human Functional pEC50 = 6.0 6.0 -2089 11
In a calcium mobilisation asay.In a calcium mobilisation asay.
Guide to Pharmacology None None None None 25517090
CHEMBL235363 3694 None 31 Human Functional pEC50 = 6.0 6.0 -2089 11
In a calcium mobilisation asay.In a calcium mobilisation asay.
Guide to Pharmacology None None None None 28288109
16133849 3676 None 11 Human Functional pEC50 = 5.4 5.4 -66069 4
In a calcium mobilisation assay.In a calcium mobilisation assay.
Guide to Pharmacology None None None None 23396314
2020 3676 None 11 Human Functional pEC50 = 5.4 5.4 -66069 4
In a calcium mobilisation assay.In a calcium mobilisation assay.
Guide to Pharmacology None None None None 23396314
91935900 3676 None 11 Human Functional pEC50 = 5.4 5.4 -66069 4
In a calcium mobilisation assay.In a calcium mobilisation assay.
Guide to Pharmacology None None None None 23396314
CHEMBL501796 3676 None 11 Human Functional pEC50 = 5.4 5.4 -66069 4
In a calcium mobilisation assay.In a calcium mobilisation assay.
Guide to Pharmacology None None None None 23396314
12988 1580 None 0 Human Functional pEC50 = 5.4 5.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology 673 5 2 9 6.2 NC1=C(C#N)C2=C(C=CC(F)=C2S1)C3=C(F)C4=NC(OC[C@@]56CCCN5C[C@H](F)C6)=NC(N7CC8CCC(C7)N8)=C4C=C3C(F)(F)F 37321326
164904685 1580 None 0 Human Functional pEC50 = 5.4 5.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology 673 5 2 9 6.2 NC1=C(C#N)C2=C(C=CC(F)=C2S1)C3=C(F)C4=NC(OC[C@@]56CCCN5C[C@H](F)C6)=NC(N7CC8CCC(C7)N8)=C4C=C3C(F)(F)F 37321326
2855 1104 None 0 Human Functional pEC50 = 5.7 5.7 - 1
UnclassifiedUnclassified
Guide to Pharmacology 519 16 3 6 4.2 CNCCc1cc(Cc2cc(CCNC)ccc2OC)c(c(c1)Cc1cc(CCNC)ccc1OC)OC 28288109
5531 1104 None 0 Human Functional pEC50 = 5.7 5.7 - 1
UnclassifiedUnclassified
Guide to Pharmacology 519 16 3 6 4.2 CNCCc1cc(Cc2cc(CCNC)ccc2OC)c(c(c1)Cc1cc(CCNC)ccc1OC)OC 28288109
9566 3426 None 17 Human Functional pEC50 = 6.1 6.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 307 3 0 5 2.5 CN([C@@H]1CCN(C1)c1cc(nc2n1ncc2)c1ccccc1)C 28288109
95882507 3426 None 17 Human Functional pEC50 = 6.1 6.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 307 3 0 5 2.5 CN([C@@H]1CCN(C1)c1cc(nc2n1ncc2)c1ccccc1)C 28288109
CHEMBL4520293 3426 None 17 Human Functional pEC50 = 6.1 6.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 307 3 0 5 2.5 CN([C@@H]1CCN(C1)c1cc(nc2n1ncc2)c1ccccc1)C 28288109
135407952 1060 None 0 Human Functional pEC50 = 6.5 6.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 542 4 2 6 5.8 CN1CCCN(CC1)C(=O)c1ccc2c(c1)nc1n2[C@@H](C(C)C)C(=O)Nc2c1cc(cc2)NC1CCCCCC1 19230660
5530 1060 None 0 Human Functional pEC50 = 6.5 6.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 542 4 2 6 5.8 CN1CCCN(CC1)C(=O)c1ccc2c(c1)nc1n2[C@@H](C(C)C)C(=O)Nc2c1cc(cc2)NC1CCCCCC1 19230660
CHEMBL463274 1060 None 0 Human Functional pEC50 = 6.5 6.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 542 4 2 6 5.8 CN1CCCN(CC1)C(=O)c1ccc2c(c1)nc1n2[C@@H](C(C)C)C(=O)Nc2c1cc(cc2)NC1CCCCCC1 19230660
2007 1170 None 0 Human Functional pEC50 = 7.3 7.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12915402
2007 1170 None 0 Human Functional pEC50 = 7.3 7.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15823563
2007 1170 None 0 Human Functional pEC50 = 7.3 7.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23396314
2007 1170 None 0 Human Functional pEC50 = 7.3 7.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 28288109
4056 2998 None 0 Human Functional pEC50 = 7.5 7.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15823563




Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name
GPCRdb
ID
Reference
ligand
Vendors

Species

Assay
Type
Activity
Type
Activity
Relation
Activity
Value
p-value
(-log)
Fold
selectivity
Tested
GPCRs
Assay
Description
Source

Mol
weight
Rot
Bonds
H don

H acc

LogP

Smiles

DOI

9566 3426 None 17 Human Binding pEC50 = 6 6.0 - 5
FLIPR assayFLIPR assay
ChEMBL 307 3 0 5 2.5 CN([C@@H]1CCN(C1)c1cc(nc2n1ncc2)c1ccccc1)C 10.6019/CHEMBL4507322
95882507 3426 None 17 Human Binding pEC50 = 6 6.0 - 5
FLIPR assayFLIPR assay
ChEMBL 307 3 0 5 2.5 CN([C@@H]1CCN(C1)c1cc(nc2n1ncc2)c1ccccc1)C 10.6019/CHEMBL4507322
CHEMBL4520293 3426 None 17 Human Binding pEC50 = 6 6.0 - 5
FLIPR assayFLIPR assay
ChEMBL 307 3 0 5 2.5 CN([C@@H]1CCN(C1)c1cc(nc2n1ncc2)c1ccccc1)C 10.6019/CHEMBL4507322
9566 3426 None 17 Human Binding pEC50 = 6 6.0 - 5
Selectivity interaction (FLIPR assay) EUB0000353a MRGPRX2Selectivity interaction (FLIPR assay) EUB0000353a MRGPRX2
ChEMBL 307 3 0 5 2.5 CN([C@@H]1CCN(C1)c1cc(nc2n1ncc2)c1ccccc1)C 10.6019/CHEMBL5212743
95882507 3426 None 17 Human Binding pEC50 = 6 6.0 - 5
Selectivity interaction (FLIPR assay) EUB0000353a MRGPRX2Selectivity interaction (FLIPR assay) EUB0000353a MRGPRX2
ChEMBL 307 3 0 5 2.5 CN([C@@H]1CCN(C1)c1cc(nc2n1ncc2)c1ccccc1)C 10.6019/CHEMBL5212743
CHEMBL4520293 3426 None 17 Human Binding pEC50 = 6 6.0 - 5
Selectivity interaction (FLIPR assay) EUB0000353a MRGPRX2Selectivity interaction (FLIPR assay) EUB0000353a MRGPRX2
ChEMBL 307 3 0 5 2.5 CN([C@@H]1CCN(C1)c1cc(nc2n1ncc2)c1ccccc1)C 10.6019/CHEMBL5212743
12074028 190995 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonistic activity at MRGPRX2 (unknown origin)Agonistic activity at MRGPRX2 (unknown origin)
ChEMBL 344 1 1 3 3.9 CN1CC[C@]2(c3cccc(O)c3)Cc3nc4ccccc4cc3C[C@@H]2C1 10.1016/j.bmcl.2021.128485
CHEMBL5184932 190995 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonistic activity at MRGPRX2 (unknown origin)Agonistic activity at MRGPRX2 (unknown origin)
ChEMBL 344 1 1 3 3.9 CN1CC[C@]2(c3cccc(O)c3)Cc3nc4ccccc4cc3C[C@@H]2C1 10.1016/j.bmcl.2021.128485
9566 3426 None 17 Human Binding pEC50 = 6.1 6.1 - 5
Affinity On-target Cellular interaction (PRESTO-Tango concentration response assay (by the NIMH-PDSP)) EUB0000353a MRGPRX2Affinity On-target Cellular interaction (PRESTO-Tango concentration response assay (by the NIMH-PDSP)) EUB0000353a MRGPRX2
ChEMBL 307 3 0 5 2.5 CN([C@@H]1CCN(C1)c1cc(nc2n1ncc2)c1ccccc1)C 10.6019/CHEMBL5210121
95882507 3426 None 17 Human Binding pEC50 = 6.1 6.1 - 5
Affinity On-target Cellular interaction (PRESTO-Tango concentration response assay (by the NIMH-PDSP)) EUB0000353a MRGPRX2Affinity On-target Cellular interaction (PRESTO-Tango concentration response assay (by the NIMH-PDSP)) EUB0000353a MRGPRX2
ChEMBL 307 3 0 5 2.5 CN([C@@H]1CCN(C1)c1cc(nc2n1ncc2)c1ccccc1)C 10.6019/CHEMBL5210121
CHEMBL4520293 3426 None 17 Human Binding pEC50 = 6.1 6.1 - 5
Affinity On-target Cellular interaction (PRESTO-Tango concentration response assay (by the NIMH-PDSP)) EUB0000353a MRGPRX2Affinity On-target Cellular interaction (PRESTO-Tango concentration response assay (by the NIMH-PDSP)) EUB0000353a MRGPRX2
ChEMBL 307 3 0 5 2.5 CN([C@@H]1CCN(C1)c1cc(nc2n1ncc2)c1ccccc1)C 10.6019/CHEMBL5210121
9566 3426 None 17 Human Binding pEC50 = 6.1 6.1 - 5
PRESTO-Tango concentration response assayPRESTO-Tango concentration response assay
ChEMBL 307 3 0 5 2.5 CN([C@@H]1CCN(C1)c1cc(nc2n1ncc2)c1ccccc1)C 10.6019/CHEMBL4507322
95882507 3426 None 17 Human Binding pEC50 = 6.1 6.1 - 5
PRESTO-Tango concentration response assayPRESTO-Tango concentration response assay
ChEMBL 307 3 0 5 2.5 CN([C@@H]1CCN(C1)c1cc(nc2n1ncc2)c1ccccc1)C 10.6019/CHEMBL4507322
CHEMBL4520293 3426 None 17 Human Binding pEC50 = 6.1 6.1 - 5
PRESTO-Tango concentration response assayPRESTO-Tango concentration response assay
ChEMBL 307 3 0 5 2.5 CN([C@@H]1CCN(C1)c1cc(nc2n1ncc2)c1ccccc1)C 10.6019/CHEMBL4507322
129072557 177311 None 6 Human Binding pEC50 = 6.1 6.1 - 0
Agonist activity at MRGPX2 (unknown origin)Agonist activity at MRGPX2 (unknown origin)
ChEMBL 763 9 5 10 3.1 Cc1cc(C[C@@H](NC(=O)N2CCC3(CC2)OC(=O)Nc2ncccc23)C(=O)N[C@@H](CC2CCNCC2)C(=O)N2CCN(c3ccncc3)CC2)cc2cn[nH]c12 10.1021/acs.jmedchem.0c01003
CHEMBL4635331 177311 None 6 Human Binding pEC50 = 6.1 6.1 - 0
Agonist activity at MRGPX2 (unknown origin)Agonist activity at MRGPX2 (unknown origin)
ChEMBL 763 9 5 10 3.1 Cc1cc(C[C@@H](NC(=O)N2CCC3(CC2)OC(=O)Nc2ncccc23)C(=O)N[C@@H](CC2CCNCC2)C(=O)N2CCN(c3ccncc3)CC2)cc2cn[nH]c12 10.1021/acs.jmedchem.0c01003