Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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 Activity
Type		 Activity
Relation		 Activity
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selectivity		 Tested
GPCRs		 Assay
Description		 Source

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155146067 184713 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 321 4 1 3 4.1 N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1 nan
CHEMBL4848977 184713 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 321 4 1 3 4.1 N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1 nan
155154170 184854 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1 nan
CHEMBL4850889 184854 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1 nan
155146047 186703 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 355 4 1 3 4.5 N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
CHEMBL4878726 186703 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 355 4 1 3 4.5 N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
3238641 31413 None 31 Human Functional pIC50 = 7 7.0 354 2
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 258 5 1 3 3.0 COc1ccc(OCc2cccc(C(=O)O)c2)cc1 nan
CHEMBL1402510 31413 None 31 Human Functional pIC50 = 7 7.0 354 2
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 258 5 1 3 3.0 COc1ccc(OCc2cccc(C(=O)O)c2)cc1 nan
2566134 69135 None 7 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 312 4 1 2 5.0 O=C(O)c1cccc(CSc2ccc(Cl)cc2Cl)c1 nan
CHEMBL1923999 69135 None 7 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 312 4 1 2 5.0 O=C(O)c1cccc(CSc2ccc(Cl)cc2Cl)c1 nan
584653 184524 None 34 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 306 4 1 2 3.7 O=C(O)c1cccc(COc2ccc(Br)cc2)c1 nan
CHEMBL4846114 184524 None 34 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 306 4 1 2 3.7 O=C(O)c1cccc(COc2ccc(Br)cc2)c1 nan
155153910 184529 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 312 4 1 2 4.8 O=C(O)c1cccc(COc2cc3ccccc3cc2Cl)c1 nan
CHEMBL4846170 184529 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 312 4 1 2 4.8 O=C(O)c1cccc(COc2cc3ccccc3cc2Cl)c1 nan
155145976 184562 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ncc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4846676 184562 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ncc(C(F)(F)F)cc2Cl)c1 nan
155154008 184580 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 368 5 1 3 4.2 N#CCNC(=O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1 nan
CHEMBL4846959 184580 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 368 5 1 3 4.2 N#CCNC(=O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1 nan
155154202 184595 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 407 5 1 4 3.6 CS(=O)(=O)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4847181 184595 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 407 5 1 4 3.6 CS(=O)(=O)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155153982 184605 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 302 5 1 2 4.5 O=C(O)c1cccc(COc2ccc(C3CC3)cc2Cl)c1 nan
CHEMBL4847374 184605 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 302 5 1 2 4.5 O=C(O)c1cccc(COc2ccc(C3CC3)cc2Cl)c1 nan
7015981 184663 None 27 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2cccc(Cl)c2Cl)c1 nan
CHEMBL4848369 184663 None 27 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2cccc(Cl)c2Cl)c1 nan
155154180 184689 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 386 6 2 3 3.2 NC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4848664 184689 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 386 6 2 3 3.2 NC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
114322379 184698 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 287 4 1 3 3.5 N#Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1 nan
CHEMBL4848825 184698 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 287 4 1 3 3.5 N#Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1 nan
155153838 184726 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 302 4 1 3 4.3 O=C(O)c1cccc(COc2ccc3sccc3c2)c1F nan
CHEMBL4849270 184726 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 302 4 1 3 4.3 O=C(O)c1cccc(COc2ccc3sccc3c2)c1F nan
155153758 184752 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 291 4 0 4 3.4 COC(=O)c1cccc(COc2ccc(Cl)cc2C)n1 nan
CHEMBL4849588 184752 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 291 4 0 4 3.4 COC(=O)c1cccc(COc2ccc(Cl)cc2C)n1 nan
155153970 184782 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 340 4 1 2 4.4 O=C(O)c1cccc(COc2cccc(Br)c2Cl)c1 nan
CHEMBL4849913 184782 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 340 4 1 2 4.4 O=C(O)c1cccc(COc2cccc(Br)c2Cl)c1 nan
155154172 184835 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 330 4 1 2 4.6 O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1 nan
CHEMBL4850633 184835 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 330 4 1 2 4.6 O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1 nan
155154044 184910 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 415 6 2 3 4.5 CC(C)(NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O nan
CHEMBL4851715 184910 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 415 6 2 3 4.5 CC(C)(NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O nan
155145940 185120 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 311 3 0 2 4.8 N#Cc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4854872 185120 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 311 3 0 2 4.8 N#Cc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
84614649 185140 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 278 5 1 2 3.9 O=C(O)c1cccc(COc2ccc(C(F)F)cc2)c1 nan
CHEMBL4855127 185140 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 278 5 1 2 3.9 O=C(O)c1cccc(COc2ccc(C(F)F)cc2)c1 nan
155153740 185159 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 325 5 1 3 4.2 Cc1cc(-n2cccc2)ccc1OCc1cccc(C(=O)O)c1F nan
CHEMBL4855384 185159 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 325 5 1 3 4.2 Cc1cc(-n2cccc2)ccc1OCc1cccc(C(=O)O)c1F nan
107881084 185172 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 314 4 1 2 4.4 O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1F nan
CHEMBL4855567 185172 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 314 4 1 2 4.4 O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1F nan
155154045 185208 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 493 8 3 4 5.1 O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4856071 185208 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 493 8 3 4 5.1 O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155146040 185230 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 349 1 1 2 4.3 N#Cc1cc(C#Cc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
CHEMBL4856356 185230 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 349 1 1 2 4.3 N#Cc1cc(C#Cc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
155145911 185263 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 329 4 1 2 4.0 NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4857097 185263 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 329 4 1 2 4.0 NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
102723930 185264 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 287 4 1 3 3.5 N#Cc1ccc(OCc2cccc(C(=O)O)c2)cc1Cl nan
CHEMBL4857110 185264 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 287 4 1 3 3.5 N#Cc1ccc(OCc2cccc(C(=O)O)c2)cc1Cl nan
155154009 185265 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 423 6 2 4 3.5 O=C(NCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1 nan
CHEMBL4857124 185265 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 423 6 2 4 3.5 O=C(NCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1 nan
155153960 185312 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 398 4 1 2 5.7 O=C(O)c1cc(COc2ccc(C(F)(F)F)c(Cl)c2)cc(C(F)(F)F)c1 nan
CHEMBL4857656 185312 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 398 4 1 2 5.7 O=C(O)c1cc(COc2ccc(C(F)(F)F)c(Cl)c2)cc(C(F)(F)F)c1 nan
155153995 185383 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccn1 nan
CHEMBL4858920 185383 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccn1 nan
155153774 185391 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 305 4 1 3 3.6 N#Cc1cc(Cl)c(F)cc1OCc1cccc(C(=O)O)c1 nan
CHEMBL4859063 185391 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 305 4 1 3 3.6 N#Cc1cc(Cl)c(F)cc1OCc1cccc(C(=O)O)c1 nan
155154005 185397 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 284 4 1 3 4.2 O=C(O)c1cccc(COc2ccc3ccsc3c2)c1 nan
CHEMBL4859171 185397 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 284 4 1 3 4.2 O=C(O)c1cccc(COc2ccc3ccsc3c2)c1 nan
155146005 185399 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 429 7 2 3 4.8 CC(C)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O nan
CHEMBL4859266 185399 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 429 7 2 3 4.8 CC(C)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O nan
106903220 185424 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 277 4 1 3 3.3 Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)n1 nan
CHEMBL4859510 185424 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 277 4 1 3 3.3 Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)n1 nan
155153791 185444 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 293 5 1 3 3.8 O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2)c1 nan
CHEMBL4859833 185444 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 293 5 1 3 3.8 O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2)c1 nan
155154252 185445 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 321 4 1 3 4.1 N#Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O nan
CHEMBL4859840 185445 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 321 4 1 3 4.1 N#Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O nan
155154021 185457 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 405 5 1 2 6.2 O=C(Nc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4860115 185457 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 405 5 1 2 6.2 O=C(Nc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155154007 185574 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 419 6 1 2 5.9 O=C(NCc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4861940 185574 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 419 6 1 2 5.9 O=C(NCc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
22682941 185607 None 1 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2)c1 nan
CHEMBL4862434 185607 None 1 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2)c1 nan
155153807 185662 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 268 4 1 3 3.7 O=C(O)c1cccc(COc2ccc3occc3c2)c1 nan
CHEMBL4863225 185662 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 268 4 1 3 3.7 O=C(O)c1cccc(COc2ccc3occc3c2)c1 nan
155153800 185704 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 321 4 1 3 3.9 N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(C(F)(F)F)c1 nan
CHEMBL4863762 185704 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 321 4 1 3 3.9 N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(C(F)(F)F)c1 nan
43531176 185724 None 1 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 281 4 1 2 4.0 NCc1cccc(COc2ccc(Cl)cc2Cl)c1 nan
CHEMBL4864076 185724 None 1 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 281 4 1 2 4.0 NCc1cccc(COc2ccc(Cl)cc2Cl)c1 nan
137553505 185733 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 312 5 1 3 3.9 O=C(O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1 nan
CHEMBL4864265 185733 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 312 5 1 3 3.9 O=C(O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1 nan
155154133 185780 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 5 1 2 4.0 O=C(O)c1cccc(COc2ccc(C(F)F)cc2F)c1 nan
CHEMBL4865044 185780 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 5 1 2 4.0 O=C(O)c1cccc(COc2ccc(C(F)F)cc2F)c1 nan
7022231 185844 None 22 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 258 5 1 3 3.0 COc1cccc(OCc2cccc(C(=O)O)c2)c1 nan
CHEMBL4866106 185844 None 22 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 258 5 1 3 3.0 COc1cccc(OCc2cccc(C(=O)O)c2)c1 nan
113925944 185851 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 260 4 1 2 3.4 Cc1ccc(OCc2cccc(C(=O)O)c2)cc1F nan
CHEMBL4866201 185851 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 260 4 1 2 3.4 Cc1ccc(OCc2cccc(C(=O)O)c2)cc1F nan
155153793 185854 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 330 4 1 2 4.6 O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2Cl)c1 nan
CHEMBL4866223 185854 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 330 4 1 2 4.6 O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2Cl)c1 nan
29080666 185870 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.0 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2)c1 nan
CHEMBL4866428 185870 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.0 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2)c1 nan
155154248 185886 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 310 4 1 2 4.6 Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O nan
CHEMBL4866577 185886 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 310 4 1 2 4.6 Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O nan
155153775 185900 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 354 4 1 4 4.1 FC(F)(F)c1cc(Cl)ccc1OCc1cccc(-c2nnn[nH]2)c1 nan
CHEMBL4866840 185900 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 354 4 1 4 4.1 FC(F)(F)c1cc(Cl)ccc1OCc1cccc(-c2nnn[nH]2)c1 nan
155145950 185949 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 376 5 0 3 5.3 CCOC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F nan
CHEMBL4867568 185949 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 376 5 0 3 5.3 CCOC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F nan
155153837 185951 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 398 4 1 2 5.7 O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(F)(F)F)c1 nan
CHEMBL4867604 185951 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 398 4 1 2 5.7 O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(F)(F)F)c1 nan
155146125 185957 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 444 8 3 4 3.0 NC(=O)C[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O nan
CHEMBL4867684 185957 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 444 8 3 4 3.0 NC(=O)C[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O nan
43092667 185960 None 1 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 287 4 1 3 3.5 N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1 nan
CHEMBL4867744 185960 None 1 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 287 4 1 3 3.5 N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1 nan
155154000 185976 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 267 4 1 3 3.1 Cc1cc(C#N)ccc1OCc1cccc(C(=O)O)c1 nan
CHEMBL4868055 185976 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 267 4 1 3 3.1 Cc1cc(C#N)ccc1OCc1cccc(C(=O)O)c1 nan
155154006 185988 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 385 7 1 2 5.5 CCCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4868255 185988 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 385 7 1 2 5.5 CCCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155153812 186030 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 284 4 1 3 4.2 O=C(O)c1cccc(COc2ccc3sccc3c2)c1 nan
CHEMBL4869118 186030 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 284 4 1 3 4.2 O=C(O)c1cccc(COc2ccc3sccc3c2)c1 nan
155153736 186045 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 345 5 1 3 4.5 O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2Cl)c1F nan
CHEMBL4869336 186045 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 345 5 1 3 4.5 O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2Cl)c1F nan
155154048 186046 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 516 8 3 3 5.8 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4869352 186046 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 516 8 3 3 5.8 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155153773 186075 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 298 4 1 4 2.8 Cc1c(OCc2cccc(C(=O)O)c2)ccc2c1OCC2=O nan
CHEMBL4869694 186075 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 298 4 1 4 2.8 Cc1c(OCc2cccc(C(=O)O)c2)ccc2c1OCC2=O nan
155154141 186144 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 411 5 1 4 5.6 Cc1nc(-c2cc(COc3ccc(C(F)(F)F)cc3Cl)cc(C(=O)O)c2)co1 nan
CHEMBL4870727 186144 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 411 5 1 4 5.6 Cc1nc(-c2cc(COc3ccc(C(F)(F)F)cc3Cl)cc(C(=O)O)c2)co1 nan
155154020 186160 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 387 7 2 3 4.1 O=C(NCCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4870998 186160 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 387 7 2 3 4.1 O=C(NCCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155154205 186186 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 373 6 2 3 3.7 O=C(NCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4871418 186186 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 373 6 2 3 3.7 O=C(NCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155154075 186233 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 344 4 0 3 4.7 COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4871892 186233 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 344 4 0 3 4.7 COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155153810 186241 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 343 4 1 2 4.3 CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4872055 186241 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 343 4 1 2 4.3 CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155153994 186258 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 294 6 1 3 3.6 O=C(O)c1cccc(COc2ccc(OC(F)F)cc2)c1 nan
CHEMBL4872342 186258 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 294 6 1 3 3.6 O=C(O)c1cccc(COc2ccc(OC(F)F)cc2)c1 nan
155154215 186285 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 458 9 3 4 3.4 NC(=O)CC[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O nan
CHEMBL4872646 186285 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 458 9 3 4 3.4 NC(=O)CC[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O nan
155154082 186291 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 260 4 0 3 3.2 COC(=O)c1cccc(COc2cccc(F)c2)c1 nan
CHEMBL4872725 186291 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 260 4 0 3 3.2 COC(=O)c1cccc(COc2cccc(F)c2)c1 nan
890775 186316 None 29 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 258 5 1 3 3.0 COc1ccccc1OCc1cccc(C(=O)O)c1 nan
CHEMBL4873123 186316 None 29 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 258 5 1 3 3.0 COc1ccccc1OCc1cccc(C(=O)O)c1 nan
584777 186336 None 35 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 262 4 1 2 3.6 O=C(O)c1cccc(COc2ccc(Cl)cc2)c1 nan
CHEMBL4873423 186336 None 35 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 262 4 1 2 3.6 O=C(O)c1cccc(COc2ccc(Cl)cc2)c1 nan
155154016 186361 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 371 5 1 2 5.1 CC(C)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4873773 186361 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 371 5 1 2 5.1 CC(C)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155153999 186375 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 276 4 1 2 3.9 Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1 nan
CHEMBL4873923 186375 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 276 4 1 2 3.9 Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1 nan
155146134 186376 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 352 4 1 2 5.3 FC(F)(F)c1ccc(OCc2cccc(-c3ncc[nH]3)c2)c(Cl)c1 nan
CHEMBL4873967 186376 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 352 4 1 2 5.3 FC(F)(F)c1ccc(OCc2cccc(-c3ncc[nH]3)c2)c(Cl)c1 nan
155146091 186423 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 329 5 1 2 4.7 CNCc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4874662 186423 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 329 5 1 2 4.7 CNCc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155153987 186463 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 364 5 1 3 4.7 O=C(O)c1cc(F)cc(COc2ccc(OC(F)(F)F)cc2Cl)c1 nan
CHEMBL4875200 186463 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 364 5 1 3 4.7 O=C(O)c1cc(F)cc(COc2ccc(OC(F)(F)F)cc2Cl)c1 nan
156048221 186467 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 437 7 2 4 3.6 O=C(NCCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1 nan
CHEMBL4875343 186467 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 437 7 2 4 3.6 O=C(NCCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1 nan
155154219 186470 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 417 7 3 4 3.1 O=C(N[C@@H](CO)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4875377 186470 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 417 7 3 4 3.1 O=C(N[C@@H](CO)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
832097 186560 None 27 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 278 4 1 2 4.1 O=C(O)c1cccc(COc2ccc3ccccc3c2)c1 nan
CHEMBL4876586 186560 None 27 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 278 4 1 2 4.1 O=C(O)c1cccc(COc2ccc3ccccc3c2)c1 nan
155153971 186574 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 267 4 1 3 3.1 Cc1cc(OCc2cccc(C(=O)O)c2)ccc1C#N nan
CHEMBL4876749 186574 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 267 4 1 3 3.1 Cc1cc(OCc2cccc(C(=O)O)c2)ccc1C#N nan
155145974 186588 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 353 4 1 2 4.7 N#Cc1cc(CCc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
CHEMBL4876954 186588 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 353 4 1 2 4.7 N#Cc1cc(CCc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
7015989 186589 None 27 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 276 4 1 2 3.9 Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)c1 nan
CHEMBL4877006 186589 None 27 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 276 4 1 2 3.9 Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)c1 nan
155154019 186601 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 357 5 1 2 4.7 CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4877244 186601 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 357 5 1 2 4.7 CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155154178 186602 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 397 5 1 2 5.6 O=C(NC1CCCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4877261 186602 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 397 5 1 2 5.6 O=C(NC1CCCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155145948 186680 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 373 5 1 3 4.7 CN(C)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
CHEMBL4878337 186680 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 373 5 1 3 4.7 CN(C)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
155153809 186688 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 383 5 1 2 5.2 O=C(NC1CCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4878428 186688 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 383 5 1 2 5.2 O=C(NC1CCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155153794 186718 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 364 4 1 2 5.3 O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1Cl nan
CHEMBL4879041 186718 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 364 4 1 2 5.3 O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1Cl nan
929494 39014 None 29 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 268 4 1 2 3.5 O=C(O)c1cccc(COc2ccc3c(c2)CCC3)c1 nan
CHEMBL1468323 39014 None 29 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 268 4 1 2 3.5 O=C(O)c1cccc(COc2ccc3c(c2)CCC3)c1 nan
725872 42609 None 33 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 286 4 1 3 3.9 O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)o1 nan
CHEMBL1500515 42609 None 33 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 286 4 1 3 3.9 O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)o1 nan
891145 52065 None 30 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 272 6 1 3 3.4 CCOc1ccc(OCc2cccc(C(=O)O)c2)cc1 nan
CHEMBL1587117 52065 None 30 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 272 6 1 3 3.4 CCOc1ccc(OCc2cccc(C(=O)O)c2)cc1 nan
155146121 184541 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 358 5 1 2 5.2 CCc1c(COc2ccc(C(F)(F)F)cc2Cl)cccc1C(=O)O nan
CHEMBL4846341 184541 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 358 5 1 2 5.2 CCc1c(COc2ccc(C(F)(F)F)cc2Cl)cccc1C(=O)O nan
17605178 184644 None 12 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 246 4 1 2 3.1 O=C(O)c1cccc(COc2ccccc2F)c1 nan
CHEMBL4847901 184644 None 12 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 246 4 1 2 3.1 O=C(O)c1cccc(COc2ccccc2F)c1 nan
7015983 184677 None 30 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 256 4 1 2 3.6 Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1 nan
CHEMBL4848511 184677 None 30 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 256 4 1 2 3.6 Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1 nan
155154010 184683 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 425 4 0 3 4.8 O=C(c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1)N1CCC2(COC2)C1 nan
CHEMBL4848586 184683 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 425 4 0 3 4.8 O=C(c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1)N1CCC2(COC2)C1 nan
155146163 184899 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 344 4 0 3 4.7 COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1 nan
CHEMBL4851598 184899 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 344 4 0 3 4.7 COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1 nan
28542041 184902 None 1 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.0 O=C(O)c1cccc(COc2ccccc2C(F)(F)F)c1 nan
CHEMBL4851647 184902 None 1 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.0 O=C(O)c1cccc(COc2ccccc2C(F)(F)F)c1 nan
155154015 184926 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 427 5 0 3 5.2 COC1CCN(C(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)CC1 nan
CHEMBL4851939 184926 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 427 5 0 3 5.2 COC1CCN(C(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)CC1 nan
155154056 184928 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 310 5 1 2 4.4 O=C(O)c1cccc(COCc2ccc(Cl)cc2Cl)c1 nan
CHEMBL4851949 184928 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 310 5 1 2 4.4 O=C(O)c1cccc(COCc2ccc(Cl)cc2Cl)c1 nan
155154148 184935 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 260 4 1 2 3.4 Cc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1 nan
CHEMBL4852032 184935 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 260 4 1 2 3.4 Cc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1 nan
22682321 184999 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 292 5 1 3 3.6 COc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1 nan
CHEMBL4852959 184999 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 292 5 1 3 3.6 COc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1 nan
11472211 185150 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 304 5 1 2 4.6 O=C(O)c1cccc(COc2cccc(-c3ccccc3)c2)c1 nan
CHEMBL4855304 185150 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 304 5 1 2 4.6 O=C(O)c1cccc(COc2cccc(-c3ccccc3)c2)c1 nan
15487504 185174 None 1 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1ccccc1COc1ccc(Cl)cc1Cl nan
CHEMBL4855628 185174 None 1 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1ccccc1COc1ccc(Cl)cc1Cl nan
116688442 185222 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 280 4 1 2 3.8 O=C(O)c1cccc(COc2cccc(Cl)c2F)c1 nan
CHEMBL4856288 185222 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 280 4 1 2 3.8 O=C(O)c1cccc(COc2cccc(Cl)c2F)c1 nan
155154083 185274 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 326 5 0 4 4.0 COC(=O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1 nan
CHEMBL4857218 185274 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 326 5 0 4 4.0 COC(=O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1 nan
155153972 185340 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 308 5 1 3 4.1 COc1ccc(OCc2cccc(C(=O)O)c2)c2ccccc12 nan
CHEMBL4858105 185340 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 308 5 1 3 4.1 COc1ccc(OCc2cccc(C(=O)O)c2)c2ccccc12 nan
155146161 185376 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 326 5 1 3 4.3 COc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O nan
CHEMBL4858773 185376 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 326 5 1 3 4.3 COc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O nan
65339188 185390 None 1 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 326 5 1 3 4.3 COc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O nan
CHEMBL4859048 185390 None 1 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 326 5 1 3 4.3 COc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O nan
13013688 185412 None 5 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 282 3 1 2 4.5 O=C(O)c1cccc(Oc2ccc(Cl)cc2Cl)c1 nan
CHEMBL4859370 185412 None 5 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 282 3 1 2 4.5 O=C(O)c1cccc(Oc2ccc(Cl)cc2Cl)c1 nan
155146132 185451 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 297 4 1 3 3.4 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cn2)c1 nan
CHEMBL4860022 185451 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 297 4 1 3 3.4 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cn2)c1 nan
155153997 185560 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 310 4 1 2 4.6 Cc1cc(Cl)cc(Cl)c1OCc1cccc(C(=O)O)c1 nan
CHEMBL4861721 185560 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 310 4 1 2 4.6 Cc1cc(Cl)cc(Cl)c1OCc1cccc(C(=O)O)c1 nan
63531317 185577 None 1 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 314 4 1 2 4.4 O=C(O)c1ccc(F)c(COc2ccc(Cl)cc2Cl)c1 nan
CHEMBL4861974 185577 None 1 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 314 4 1 2 4.4 O=C(O)c1ccc(F)c(COc2ccc(Cl)cc2Cl)c1 nan
24225858 185582 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 301 4 0 5 3.3 COC(=O)c1cc(COc2ccc(Cl)cc2Cl)on1 nan
CHEMBL4862041 185582 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 301 4 0 5 3.3 COC(=O)c1cc(COc2ccc(Cl)cc2Cl)on1 nan
155153755 185598 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 312 4 0 5 3.1 COC(=O)c1cncc(COc2ccc(Cl)cc2Cl)n1 nan
CHEMBL4862314 185598 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 312 4 0 5 3.1 COC(=O)c1cncc(COc2ccc(Cl)cc2Cl)n1 nan
155153805 185658 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 287 4 1 3 3.5 N#Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl nan
CHEMBL4863173 185658 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 287 4 1 3 3.5 N#Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl nan
155154003 185668 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 318 5 1 2 4.9 Cc1cc(-c2ccccc2)ccc1OCc1cccc(C(=O)O)c1 nan
CHEMBL4863275 185668 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 318 5 1 2 4.9 Cc1cc(-c2ccccc2)ccc1OCc1cccc(C(=O)O)c1 nan
155154024 185706 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 268 5 1 2 3.8 O=C(O)c1cccc(COc2ccc(C3CC3)cc2)c1 nan
CHEMBL4863823 185706 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 268 5 1 2 3.8 O=C(O)c1cccc(COc2ccc(C3CC3)cc2)c1 nan
17605176 185708 None 1 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 272 6 1 3 3.4 CCOc1ccccc1OCc1cccc(C(=O)O)c1 nan
CHEMBL4863854 185708 None 1 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 272 6 1 3 3.4 CCOc1ccccc1OCc1cccc(C(=O)O)c1 nan
584738 185730 None 28 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2cc(Cl)ccc2Cl)c1 nan
CHEMBL4864171 185730 None 28 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2cc(Cl)ccc2Cl)c1 nan
155154171 185747 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 268 4 1 2 3.5 O=C(O)c1cccc(COc2cccc3c2CCC3)c1 nan
CHEMBL4864441 185747 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 268 4 1 2 3.5 O=C(O)c1cccc(COc2cccc3c2CCC3)c1 nan
20991272 185901 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 298 4 1 2 4.6 Cc1ccc(C(C)(C)C)c(OCc2cccc(C(=O)O)c2)c1 nan
CHEMBL4866841 185901 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 298 4 1 2 4.6 Cc1ccc(C(C)(C)C)c(OCc2cccc(C(=O)O)c2)c1 nan
20985043 185905 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2cc(Cl)cc(Cl)c2)c1 nan
CHEMBL4866888 185905 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2cc(Cl)cc(Cl)c2)c1 nan
721137 185913 None 39 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 292 5 1 3 3.6 COc1cc(C(=O)O)ccc1OCc1ccc(Cl)cc1 nan
CHEMBL4866984 185913 None 39 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 292 5 1 3 3.6 COc1cc(C(=O)O)ccc1OCc1ccc(Cl)cc1 nan
155153808 185972 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 3 3.5 O=C(O)c1cccc(COc2cccc3c2CCCC3=O)c1 nan
CHEMBL4868006 185972 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 3 3.5 O=C(O)c1cccc(COc2cccc3c2CCCC3=O)c1 nan
82096332 186019 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 295 4 2 2 4.3 O=C(O)c1cccc(CNc2ccc(Cl)cc2Cl)c1 nan
CHEMBL4868865 186019 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 295 4 2 2 4.3 O=C(O)c1cccc(CNc2ccc(Cl)cc2Cl)c1 nan
155153803 186074 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 372 6 2 3 3.6 NCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4869674 186074 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 372 6 2 3 3.6 NCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155153783 186122 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 285 5 2 3 2.3 CNC(=O)c1ccc(OCc2cccc(C(=O)O)c2)cc1 nan
CHEMBL4870496 186122 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 285 5 2 3 2.3 CNC(=O)c1ccc(OCc2cccc(C(=O)O)c2)cc1 nan
155154195 186126 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 310 4 1 2 4.6 Cc1ccc(C(=O)O)cc1COc1ccc(Cl)cc1Cl nan
CHEMBL4870512 186126 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 310 4 1 2 4.6 Cc1ccc(C(=O)O)cc1COc1ccc(Cl)cc1Cl nan
8977162 186194 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 301 4 0 4 3.6 COC(=O)c1cccc(COc2ccc(C#N)cc2Cl)c1 nan
CHEMBL4871542 186194 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 301 4 0 4 3.6 COC(=O)c1cccc(COc2ccc(C#N)cc2Cl)c1 nan
155153984 186208 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 304 5 1 3 3.8 CC(=O)c1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1 nan
CHEMBL4871699 186208 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 304 5 1 3 3.8 CC(=O)c1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1 nan
3288323 186218 None 29 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 270 5 1 2 4.1 CC(C)c1ccc(OCc2cccc(C(=O)O)c2)cc1 nan
CHEMBL4871766 186218 None 29 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 270 5 1 2 4.1 CC(C)c1ccc(OCc2cccc(C(=O)O)c2)cc1 nan
155153862 186273 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 282 4 1 2 4.1 OCc1cccc(COc2ccc(Cl)cc2Cl)c1 nan
CHEMBL4872542 186273 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 282 4 1 2 4.1 OCc1cccc(COc2ccc(Cl)cc2Cl)c1 nan
155146072 186296 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 353 4 1 3 4.7 FC(F)(F)c1ccc(OCc2cccc(-c3cn[nH]n3)c2)c(Cl)c1 nan
CHEMBL4872766 186296 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 353 4 1 3 4.7 FC(F)(F)c1ccc(OCc2cccc(-c3cn[nH]n3)c2)c(Cl)c1 nan
155153991 186368 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 321 4 1 3 4.1 N#Cc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O nan
CHEMBL4873848 186368 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 321 4 1 3 4.1 N#Cc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O nan
14974397 186386 None 1 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.0 O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2)c1 nan
CHEMBL4874104 186386 None 1 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.0 O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2)c1 nan
155154050 186397 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 316 4 0 4 4.4 COC(=O)c1ccc(COc2ccc(Cl)cc2Cl)s1 nan
CHEMBL4874272 186397 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 316 4 0 4 4.4 COC(=O)c1ccc(COc2ccc(Cl)cc2Cl)s1 nan
81781305 186508 None 1 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 260 4 1 2 3.4 Cc1cc(F)ccc1OCc1cccc(C(=O)O)c1 nan
CHEMBL4875899 186508 None 1 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 260 4 1 2 3.4 Cc1cc(F)ccc1OCc1cccc(C(=O)O)c1 nan
155146174 186540 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 336 4 0 1 5.9 FC(F)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4876298 186540 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 336 4 0 1 5.9 FC(F)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155154076 186595 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 297 4 1 3 3.4 O=C(O)c1cccc(COc2ccc(C(F)(F)F)nc2)c1 nan
CHEMBL4877160 186595 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 297 4 1 3 3.4 O=C(O)c1cccc(COc2ccc(C(F)(F)F)nc2)c1 nan
155153754 186689 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 327 5 0 5 2.9 COC(=O)c1cccc(COc2ccc(N3CCOCC3)cc2)c1 nan
CHEMBL4878462 186689 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 327 5 0 5 2.9 COC(=O)c1cccc(COc2ccc(N3CCOCC3)cc2)c1 nan
155154070 186726 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 298 4 1 2 4.6 Cc1cc(C(C)(C)C)ccc1OCc1cccc(C(=O)O)c1 nan
CHEMBL4879226 186726 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 298 4 1 2 4.6 Cc1cc(C(C)(C)C)ccc1OCc1cccc(C(=O)O)c1 nan
155154170 184854 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1 nan
CHEMBL4850889 184854 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1 nan
155145968 185131 None 9 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F nan
CHEMBL4855031 185131 None 9 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F nan
155154002 184974 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 328 4 1 2 4.4 Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F nan
CHEMBL4852609 184974 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 328 4 1 2 4.4 Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F nan
155145900 186214 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4871722 186214 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155153792 185931 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 330 4 1 2 4.9 O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1 nan
CHEMBL4867400 185931 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 330 4 1 2 4.9 O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1 nan
4366362 184791 None 32 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1 nan
CHEMBL4850008 184791 None 32 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1 nan
4366362 184791 None 32 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1 nan
CHEMBL4850008 184791 None 32 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1 nan
155145968 185131 None 9 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F nan
CHEMBL4855031 185131 None 9 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F nan
155146009 186459 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F nan
CHEMBL4875180 186459 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F nan
155146147 186486 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 344 4 1 2 4.9 Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
CHEMBL4875642 186486 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 344 4 1 2 4.9 Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
155145968 185131 None 9 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F nan
CHEMBL4855031 185131 None 9 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F nan
155146136 186644 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1 nan
CHEMBL4877820 186644 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1 nan
155145946 185377 None 11 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 359 5 1 3 4.6 CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1 nan
CHEMBL4858820 185377 None 11 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 359 5 1 3 4.6 CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1 nan
155146147 186486 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 344 4 1 2 4.9 Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
CHEMBL4875642 186486 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 344 4 1 2 4.9 Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
155145946 185377 None 11 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 359 5 1 3 4.6 CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1 nan
CHEMBL4858820 185377 None 11 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 359 5 1 3 4.6 CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1 nan
155153902 185413 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 330 4 1 2 4.6 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4859372 185413 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 330 4 1 2 4.6 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155145946 185377 None 11 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay
ChEMBL 359 5 1 3 4.6 CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1 nan
CHEMBL4858820 185377 None 11 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay
ChEMBL 359 5 1 3 4.6 CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1 nan
155153934 186159 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay
ChEMBL 335 4 1 3 4.2 Cc1cc(C(F)(F)F)ccc1OCc1cc(C#N)cc(C(=O)O)c1 nan
CHEMBL4870947 186159 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay
ChEMBL 335 4 1 3 4.2 Cc1cc(C(F)(F)F)ccc1OCc1cc(C#N)cc(C(=O)O)c1 nan
155154002 184974 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 328 4 1 2 4.4 Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F nan
CHEMBL4852609 184974 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 328 4 1 2 4.4 Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F nan
155145900 186214 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4871722 186214 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
106903214 186350 None 1 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 297 4 1 3 3.7 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1 nan
CHEMBL4873616 186350 None 1 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 297 4 1 3 3.7 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1 nan
155153792 185931 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay
ChEMBL 330 4 1 2 4.9 O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1 nan
CHEMBL4867400 185931 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay
ChEMBL 330 4 1 2 4.9 O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1 nan
155153902 185413 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 330 4 1 2 4.6 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4859372 185413 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 330 4 1 2 4.6 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155146009 186459 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F nan
CHEMBL4875180 186459 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F nan
155146147 186486 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 344 4 1 2 4.9 Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
CHEMBL4875642 186486 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 344 4 1 2 4.9 Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
155153792 185931 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 330 4 1 2 4.9 O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1 nan
CHEMBL4867400 185931 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 330 4 1 2 4.9 O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1 nan
155145946 185377 None 11 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 359 5 1 3 4.6 CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1 nan
CHEMBL4858820 185377 None 11 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 359 5 1 3 4.6 CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1 nan
155145900 186214 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4871722 186214 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155146136 186644 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1 nan
CHEMBL4877820 186644 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1 nan
155145968 185131 None 9 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F nan
CHEMBL4855031 185131 None 9 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F nan
155146147 186486 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 344 4 1 2 4.9 Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
CHEMBL4875642 186486 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 344 4 1 2 4.9 Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
155154002 184974 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 328 4 1 2 4.4 Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F nan
CHEMBL4852609 184974 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 328 4 1 2 4.4 Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F nan
155146067 184713 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 321 4 1 3 4.1 N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1 nan
CHEMBL4848977 184713 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 321 4 1 3 4.1 N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1 nan
155145900 186214 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4871722 186214 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155145968 185131 None 9 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F nan
CHEMBL4855031 185131 None 9 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F nan
106903214 186350 None 1 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 297 4 1 3 3.7 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1 nan
CHEMBL4873616 186350 None 1 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 297 4 1 3 3.7 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1 nan
4366362 184791 None 32 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1 nan
CHEMBL4850008 184791 None 32 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1 nan
155154251 185245 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 324 4 1 2 4.6 Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1 nan
CHEMBL4856731 185245 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 324 4 1 2 4.6 Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1 nan
155153792 185931 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 330 4 1 2 4.9 O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1 nan
CHEMBL4867400 185931 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 330 4 1 2 4.9 O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1 nan
155153792 185931 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 330 4 1 2 4.9 O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1 nan
CHEMBL4867400 185931 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 330 4 1 2 4.9 O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1 nan
155146136 186644 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1 nan
CHEMBL4877820 186644 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1 nan
155154251 185245 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 324 4 1 2 4.6 Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1 nan
CHEMBL4856731 185245 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 324 4 1 2 4.6 Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1 nan
155153902 185413 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 330 4 1 2 4.6 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4859372 185413 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 330 4 1 2 4.6 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
107119671 184957 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 314 4 1 2 4.4 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F nan
CHEMBL4852376 184957 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 314 4 1 2 4.4 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F nan
155146067 184713 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 321 4 1 3 4.1 N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1 nan
CHEMBL4848977 184713 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 321 4 1 3 4.1 N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1 nan
155146136 186644 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1 nan
CHEMBL4877820 186644 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1 nan
155145946 185377 None 11 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 359 5 1 3 4.6 CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1 nan
CHEMBL4858820 185377 None 11 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 359 5 1 3 4.6 CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1 nan
155145900 186214 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4871722 186214 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155146009 186459 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F nan
CHEMBL4875180 186459 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F nan
155146047 186703 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 355 4 1 3 4.5 N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
CHEMBL4878726 186703 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 355 4 1 3 4.5 N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
155146009 186459 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F nan
CHEMBL4875180 186459 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F nan
155146136 186644 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1 nan
CHEMBL4877820 186644 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1 nan
155146136 186644 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1 nan
CHEMBL4877820 186644 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1 nan
155154251 185245 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 324 4 1 2 4.6 Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1 nan
CHEMBL4856731 185245 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 324 4 1 2 4.6 Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1 nan
155146147 186486 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 344 4 1 2 4.9 Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
CHEMBL4875642 186486 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 344 4 1 2 4.9 Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
4366362 184791 None 32 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1 nan
CHEMBL4850008 184791 None 32 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1 nan
155154251 185245 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 324 4 1 2 4.6 Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1 nan
CHEMBL4856731 185245 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 324 4 1 2 4.6 Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1 nan
155146009 186459 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F nan
CHEMBL4875180 186459 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F nan
155153902 185413 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 330 4 1 2 4.6 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4859372 185413 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 330 4 1 2 4.6 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155153902 185413 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 330 4 1 2 4.6 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4859372 185413 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 330 4 1 2 4.6 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
106903214 186350 None 1 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 297 4 1 3 3.7 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1 nan
CHEMBL4873616 186350 None 1 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 297 4 1 3 3.7 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1 nan
4366362 184791 None 32 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1 nan
CHEMBL4850008 184791 None 32 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1 nan
155153780 186411 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 354 4 1 4 4.4 Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl nan
CHEMBL4874540 186411 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 354 4 1 4 4.4 Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl nan
155154170 184854 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1 nan
CHEMBL4850889 184854 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1 nan
155154170 184854 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1 nan
CHEMBL4850889 184854 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1 nan
890753 31626 None 34 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 278 4 1 2 4.1 O=C(O)c1cccc(COc2cccc3ccccc23)c1 nan
CHEMBL1404550 31626 None 34 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 278 4 1 2 4.1 O=C(O)c1cccc(COc2cccc3ccccc23)c1 nan
155146086 184602 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 336 5 1 2 4.9 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2C2CC2)c1 nan
CHEMBL4847344 184602 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 336 5 1 2 4.9 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2C2CC2)c1 nan
155146130 184617 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 355 3 1 2 4.2 O=C1NCCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc21 nan
CHEMBL4847516 184617 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 355 3 1 2 4.2 O=C1NCCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc21 nan
155154149 184620 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 278 4 1 2 3.6 Cc1cc(F)c(F)cc1OCc1cccc(C(=O)O)c1 nan
CHEMBL4847582 184620 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 278 4 1 2 3.6 Cc1cc(F)c(F)cc1OCc1cccc(C(=O)O)c1 nan
155153911 184768 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 268 4 1 3 3.7 O=C(O)c1cccc(COc2ccc3ccoc3c2)c1 nan
CHEMBL4849736 184768 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 268 4 1 3 3.7 O=C(O)c1cccc(COc2ccc3ccoc3c2)c1 nan
155146026 184838 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 352 4 1 2 5.3 FC(F)(F)c1ccc(OCc2cccc(-c3cnc[nH]3)c2)c(Cl)c1 nan
CHEMBL4850676 184838 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 352 4 1 2 5.3 FC(F)(F)c1ccc(OCc2cccc(-c3cnc[nH]3)c2)c(Cl)c1 nan
155154004 184840 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 294 5 1 3 3.3 COc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1F nan
CHEMBL4850688 184840 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 294 5 1 3 3.3 COc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1F nan
19619635 184897 None 1 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 276 4 1 2 3.9 Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl nan
CHEMBL4851582 184897 None 1 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 276 4 1 2 3.9 Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl nan
91105735 184900 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 314 4 1 2 4.1 O=C(O)c1cccc(COc2ccc(F)cc2C(F)(F)F)c1 nan
CHEMBL4851614 184900 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 314 4 1 2 4.1 O=C(O)c1cccc(COc2ccc(F)cc2C(F)(F)F)c1 nan
903815 184905 None 31 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)cc1 nan
CHEMBL4851668 184905 None 31 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)cc1 nan
155153785 184906 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 353 4 1 3 4.7 FC(F)(F)c1ccc(OCc2cccc(-c3nc[nH]n3)c2)c(Cl)c1 nan
CHEMBL4851669 184906 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 353 4 1 3 4.7 FC(F)(F)c1ccc(OCc2cccc(-c3nc[nH]n3)c2)c(Cl)c1 nan
155154017 185004 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 387 7 1 3 4.3 COCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4852989 185004 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 387 7 1 3 4.3 COCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
4442182 185006 None 35 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 306 4 1 2 3.7 O=C(O)c1cccc(COc2cccc(Br)c2)c1 nan
CHEMBL4853044 185006 None 35 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 306 4 1 2 3.7 O=C(O)c1cccc(COc2cccc(Br)c2)c1 nan
103238459 185040 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 277 4 2 2 4.2 O=C(O)c1cccc(CNc2ccc3ccccc3c2)c1 nan
CHEMBL4853544 185040 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 277 4 2 2 4.2 O=C(O)c1cccc(CNc2ccc3ccccc3c2)c1 nan
155154052 185060 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 338 4 1 2 4.1 C#Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F nan
CHEMBL4853811 185060 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 338 4 1 2 4.1 C#Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F nan
155146123 185167 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 366 4 1 3 4.2 O=S(=O)(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4855464 185167 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 366 4 1 3 4.2 O=S(=O)(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155784453 185212 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 427 5 2 3 5.0 O=C(N[C@H]1CC[C@H](O)CC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4856138 185212 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 427 5 2 3 5.0 O=C(N[C@H]1CC[C@H](O)CC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155146049 185214 None 2 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 301 3 1 2 4.5 Nc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4856167 185214 None 2 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 301 3 1 2 4.5 Nc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155154204 185224 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 427 5 2 3 5.0 O=C(NC1CCCC(O)C1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4856296 185224 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 427 5 2 3 5.0 O=C(NC1CCCC(O)C1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155154013 185258 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 406 5 1 2 6.3 O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(-c2ccccc2)c1 nan
CHEMBL4857004 185258 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 406 5 1 2 6.3 O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(-c2ccccc2)c1 nan
155153735 185367 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 349 5 1 3 4.4 O=C(O)c1cccc(COc2ccc(N3CCCC3)cc2Cl)c1F nan
CHEMBL4858571 185367 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 349 5 1 3 4.4 O=C(O)c1cccc(COc2ccc(N3CCCC3)cc2Cl)c1F nan
155153998 185431 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 279 4 1 3 3.5 O=C(O)c1cccc(COc2ccc3ccncc3c2)c1 nan
CHEMBL4859587 185431 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 279 4 1 3 3.5 O=C(O)c1cccc(COc2ccc3ccncc3c2)c1 nan
155153813 185527 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 400 6 2 3 3.4 CNC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4861329 185527 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 400 6 2 3 3.4 CNC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155154400 185532 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 400 7 1 3 4.2 CN(C)CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4861423 185532 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 400 7 1 3 4.2 CN(C)CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155154049 185536 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 431 7 3 4 3.5 C[C@@H](O)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O nan
CHEMBL4861439 185536 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 431 7 3 4 3.5 C[C@@H](O)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O nan
155154027 185539 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 330 4 1 2 4.9 O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1Cl nan
CHEMBL4861452 185539 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 330 4 1 2 4.9 O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1Cl nan
155146107 185578 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 362 4 0 3 4.9 COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F nan
CHEMBL4861980 185578 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 362 4 0 3 4.9 COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F nan
155154040 185697 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 354 4 1 4 4.1 FC(F)(F)c1ccc(OCc2ccc(-c3nnn[nH]3)cc2)c(Cl)c1 nan
CHEMBL4863644 185697 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 354 4 1 4 4.1 FC(F)(F)c1ccc(OCc2ccc(-c3nnn[nH]3)cc2)c(Cl)c1 nan
155153798 185750 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 386 7 2 3 3.9 CNCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4864507 185750 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 386 7 2 3 3.9 CNCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155154046 185755 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 401 6 2 3 4.1 C[C@@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O nan
CHEMBL4864569 185755 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 401 6 2 3 4.1 C[C@@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O nan
106903207 185757 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 263 4 1 3 3.0 O=C(O)c1cccc(COc2ccc(Cl)cc2)n1 nan
CHEMBL4864640 185757 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 263 4 1 3 3.0 O=C(O)c1cccc(COc2ccc(Cl)cc2)n1 nan
155153702 185852 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 308 4 1 4 3.3 O=C(O)c1cccc(COc2ccc3c(c2)OC(F)(F)O3)c1 nan
CHEMBL4866218 185852 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 308 4 1 4 3.3 O=C(O)c1cccc(COc2ccc3c(c2)OC(F)(F)O3)c1 nan
62669913 185884 None 2 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 276 4 1 2 3.9 Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1 nan
CHEMBL4866560 185884 None 2 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 276 4 1 2 3.9 Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1 nan
155153739 185944 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 329 5 1 3 4.0 Cc1cc(N2CCCC2)ccc1OCc1cccc(C(=O)O)c1F nan
CHEMBL4867549 185944 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 329 5 1 3 4.0 Cc1cc(N2CCCC2)ccc1OCc1cccc(C(=O)O)c1F nan
155153757 185981 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 345 4 0 4 4.1 COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1 nan
CHEMBL4868173 185981 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 345 4 0 4 4.1 COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1 nan
19620501 185999 None 1 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 302 4 1 3 4.3 O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)s1 nan
CHEMBL4868548 185999 None 1 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 302 4 1 3 4.3 O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)s1 nan
155701700 186018 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 274 4 1 2 3.7 Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1F nan
CHEMBL4868856 186018 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 274 4 1 2 3.7 Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1F nan
155153801 186026 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 322 5 1 2 4.8 O=C(O)c1cccc(COc2cccc(-c3ccc(F)cc3)c2)c1 nan
CHEMBL4869062 186026 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 322 5 1 2 4.8 O=C(O)c1cccc(COc2cccc(-c3ccc(F)cc3)c2)c1 nan
155153802 186225 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 385 4 0 3 4.4 O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCOC1 nan
CHEMBL4871829 186225 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 385 4 0 3 4.4 O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCOC1 nan
155154216 186235 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 467 8 3 4 4.1 O=C(N[C@@H](Cc1c[nH]cn1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4871932 186235 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 467 8 3 4 4.1 O=C(N[C@@H](Cc1c[nH]cn1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155154203 186272 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 413 4 1 3 4.5 O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCCC(O)C1 nan
CHEMBL4872532 186272 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 413 4 1 3 4.5 O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCCC(O)C1 nan
155154200 186298 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 385 4 1 3 3.8 O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CC(O)C1 nan
CHEMBL4872809 186298 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 385 4 1 3 3.8 O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CC(O)C1 nan
155146160 186394 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 369 3 0 2 4.6 CN1CCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc2C1=O nan
CHEMBL4874203 186394 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 369 3 0 2 4.6 CN1CCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc2C1=O nan
155146102 186424 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 355 4 1 2 4.5 O=C1CC(c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)N1 nan
CHEMBL4874670 186424 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 355 4 1 2 4.5 O=C1CC(c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)N1 nan
29789593 186430 None 1 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 277 3 0 2 4.4 N#Cc1cccc(COc2ccc(Cl)cc2Cl)c1 nan
CHEMBL4874777 186430 None 1 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 277 3 0 2 4.4 N#Cc1cccc(COc2ccc(Cl)cc2Cl)c1 nan
20984378 186564 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 290 4 1 2 4.2 Cc1cc(OCc2cccc(C(=O)O)c2)cc(C)c1Cl nan
CHEMBL4876625 186564 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 290 4 1 2 4.2 Cc1cc(OCc2cccc(C(=O)O)c2)cc(C)c1Cl nan
155154217 186590 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 449 6 2 3 5.9 O=C(O)c1ccc(NC(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)cc1 nan
CHEMBL4877028 186590 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 449 6 2 3 5.9 O=C(O)c1ccc(NC(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)cc1 nan
155154152 186607 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 280 4 1 2 3.8 O=C(O)c1cccc(COc2ccc(Cl)cc2F)c1 nan
CHEMBL4877399 186607 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 280 4 1 2 3.8 O=C(O)c1cccc(COc2ccc(Cl)cc2F)c1 nan
155153804 186656 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 326 5 1 3 4.0 COc1cc(OCc2cccc(C(=O)O)c2)ccc1C(F)(F)F nan
CHEMBL4878001 186656 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay
ChEMBL 326 5 1 3 4.0 COc1cc(OCc2cccc(C(=O)O)c2)ccc1C(F)(F)F nan
107119671 184957 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 314 4 1 2 4.4 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F nan
CHEMBL4852376 184957 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 314 4 1 2 4.4 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F nan
4366362 184791 None 32 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1 nan
CHEMBL4850008 184791 None 32 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 296 4 1 2 4.3 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1 nan
155145968 185131 None 9 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F nan
CHEMBL4855031 185131 None 9 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F nan
155146047 186703 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 355 4 1 3 4.5 N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
CHEMBL4878726 186703 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 355 4 1 3 4.5 N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
155153780 186411 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 354 4 1 4 4.4 Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl nan
CHEMBL4874540 186411 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 354 4 1 4 4.4 Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl nan
155146067 184713 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 321 4 1 3 4.1 N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1 nan
CHEMBL4848977 184713 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 321 4 1 3 4.1 N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1 nan
155146067 184713 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 321 4 1 3 4.1 N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1 nan
CHEMBL4848977 184713 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 321 4 1 3 4.1 N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1 nan
155153780 186411 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 354 4 1 4 4.4 Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl nan
CHEMBL4874540 186411 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 354 4 1 4 4.4 Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl nan
155154251 185245 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 324 4 1 2 4.6 Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1 nan
CHEMBL4856731 185245 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 324 4 1 2 4.6 Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1 nan
155153792 185931 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 330 4 1 2 4.9 O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1 nan
CHEMBL4867400 185931 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 330 4 1 2 4.9 O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1 nan
155153780 186411 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 354 4 1 4 4.4 Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl nan
CHEMBL4874540 186411 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 354 4 1 4 4.4 Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl nan
155146047 186703 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 355 4 1 3 4.5 N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
CHEMBL4878726 186703 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 355 4 1 3 4.5 N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
155145946 185377 None 11 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 359 5 1 3 4.6 CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1 nan
CHEMBL4858820 185377 None 11 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 359 5 1 3 4.6 CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1 nan
155154170 184854 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1 nan
CHEMBL4850889 184854 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1 nan
155154002 184974 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 328 4 1 2 4.4 Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F nan
CHEMBL4852609 184974 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay
ChEMBL 328 4 1 2 4.4 Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F nan
155153780 186411 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 354 4 1 4 4.4 Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl nan
CHEMBL4874540 186411 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay
ChEMBL 354 4 1 4 4.4 Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl nan
155146047 186703 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 355 4 1 3 4.5 N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
CHEMBL4878726 186703 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 355 4 1 3 4.5 N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 nan
106903214 186350 None 1 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 297 4 1 3 3.7 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1 nan
CHEMBL4873616 186350 None 1 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 297 4 1 3 3.7 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1 nan
107119671 184957 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 314 4 1 2 4.4 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F nan
CHEMBL4852376 184957 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 314 4 1 2 4.4 O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F nan
155145900 186214 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL4871722 186214 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay
ChEMBL 348 4 1 2 4.8 O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1 nan
155154170 184854 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1 nan
CHEMBL4850889 184854 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay
ChEMBL 331 4 1 3 4.0 O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1 nan
155154002 184974 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 328 4 1 2 4.4 Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F nan
CHEMBL4852609 184974 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay
ChEMBL 328 4 1 2 4.4 Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F nan


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