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Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species		Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1146	3862	None	34	Mouse		Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at mouse TAAR5 expressed in HEK293 cells assessed as increase in cAMP release after 30 mins by BRET assay relative to controlAgonist activity at mouse TAAR5 expressed in HEK293 cells assessed as increase in cAMP release after 30 mins by BRET assay relative to control	ChEMBL	59	0	0	1	0.2	CN(C)C	10.1039/C5MD00490J
	5521	3862	None	34	Mouse		Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at mouse TAAR5 expressed in HEK293 cells assessed as increase in cAMP release after 30 mins by BRET assay relative to controlAgonist activity at mouse TAAR5 expressed in HEK293 cells assessed as increase in cAMP release after 30 mins by BRET assay relative to control	ChEMBL	59	0	0	1	0.2	CN(C)C	10.1039/C5MD00490J
	CHEMBL439723	3862	None	34	Mouse		Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at mouse TAAR5 expressed in HEK293 cells assessed as increase in cAMP release after 30 mins by BRET assay relative to controlAgonist activity at mouse TAAR5 expressed in HEK293 cells assessed as increase in cAMP release after 30 mins by BRET assay relative to control	ChEMBL	59	0	0	1	0.2	CN(C)C	10.1039/C5MD00490J
	56946474	71540	None	0	Mouse		Functional	pIC50	=	4.5	4.5	-	1	Antagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assayAntagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assay	ChEMBL	403	9	1	4	4.8	COc1ccccc1OCCNCC1CCC(c2ccccc2)(c2ccccc2)O1	10.1039/C5MD00490J
	CHEMBL1946779	71540	None	0	Mouse		Functional	pIC50	=	4.5	4.5	-	1	Antagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assayAntagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assay	ChEMBL	403	9	1	4	4.8	COc1ccccc1OCCNCC1CCC(c2ccccc2)(c2ccccc2)O1	10.1039/C5MD00490J
	CHEMBL1962769	71540	None	0	Mouse		Functional	pIC50	=	4.5	4.5	-	1	Antagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assayAntagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assay	ChEMBL	403	9	1	4	4.8	COc1ccccc1OCCNCC1CCC(c2ccccc2)(c2ccccc2)O1	10.1039/C5MD00490J
	56946573	71550	None	0	Mouse		Functional	pIC50	=	5.3	5.3	-	1	Antagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assayAntagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assay	ChEMBL	428	6	0	4	4.9	COc1ccccc1N1CCN(CC2CCC(c3ccccc3)(c3ccccc3)O2)CC1	10.1039/C5MD00490J
	CHEMBL1946780	71550	None	0	Mouse		Functional	pIC50	=	5.3	5.3	-	1	Antagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assayAntagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assay	ChEMBL	428	6	0	4	4.9	COc1ccccc1N1CCN(CC2CCC(c3ccccc3)(c3ccccc3)O2)CC1	10.1039/C5MD00490J
	CHEMBL1962870	71550	None	0	Mouse		Functional	pIC50	=	5.3	5.3	-	1	Antagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assayAntagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assay	ChEMBL	428	6	0	4	4.9	COc1ccccc1N1CCN(CC2CCC(c3ccccc3)(c3ccccc3)O2)CC1	10.1039/C5MD00490J
	11723	1425	None	0	Mouse		Functional	pEC50	=	6.2	6.2	-	1	UnclassifiedUnclassified	Guide to Pharmacology	73	1	0	1	0.6	CCN(C)C	17088868
	5523	1425	None	0	Mouse		Functional	pEC50	=	6.2	6.2	-	1	UnclassifiedUnclassified	Guide to Pharmacology	73	1	0	1	0.6	CCN(C)C	17088868
	CHEMBL609099	1425	None	0	Mouse		Functional	pEC50	=	6.2	6.2	-	1	UnclassifiedUnclassified	Guide to Pharmacology	73	1	0	1	0.6	CCN(C)C	17088868
	1146	3862	None	34	Mouse		Functional	pEC50	=	6.5	6.5	-	1	UnclassifiedUnclassified	Guide to Pharmacology	59	0	0	1	0.2	CN(C)C	16878137
	5521	3862	None	34	Mouse		Functional	pEC50	=	6.5	6.5	-	1	UnclassifiedUnclassified	Guide to Pharmacology	59	0	0	1	0.2	CN(C)C	16878137
	CHEMBL439723	3862	None	34	Mouse		Functional	pEC50	=	6.5	6.5	-	1	UnclassifiedUnclassified	Guide to Pharmacology	59	0	0	1	0.2	CN(C)C	16878137

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species		Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	9950514	11862	None	9	Human		Binding	pEC50	=	5.4	5.4	-	0	Inverse agonist activity at human TAAR5 expressed in HEK293 cells by Alphascreen assayInverse agonist activity at human TAAR5 expressed in HEK293 cells by Alphascreen assay	ChEMBL	355	4	2	3	3.3	NCCc1ccc(Oc2ccc(O)cc2)c(I)c1	10.1039/C5MD00490J
	CHEMBL1182312	11862	None	9	Human		Binding	pEC50	=	5.4	5.4	-	0	Inverse agonist activity at human TAAR5 expressed in HEK293 cells by Alphascreen assayInverse agonist activity at human TAAR5 expressed in HEK293 cells by Alphascreen assay	ChEMBL	355	4	2	3	3.3	NCCc1ccc(Oc2ccc(O)cc2)c(I)c1	10.1039/C5MD00490J
	CHEMBL229288	11862	None	9	Human		Binding	pEC50	=	5.4	5.4	-	0	Inverse agonist activity at human TAAR5 expressed in HEK293 cells by Alphascreen assayInverse agonist activity at human TAAR5 expressed in HEK293 cells by Alphascreen assay	ChEMBL	355	4	2	3	3.3	NCCc1ccc(Oc2ccc(O)cc2)c(I)c1	10.1039/C5MD00490J